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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Gimeracil
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Accession:CHEBI:31652 term browser browse the term
Synonyms:related_synonym: 5-Chloro-2,4-dihydroxypyridine;   5-Chloro-4-hydroxy-2-pyridone;   Formula=C5H4ClNO2;   InChI=1S/C5H4ClNO2/c6-3-2-7-5(9)1-4(3)8/h1-2H,(H2,7,8,9);   InChIKey=ZPLQIPFOCGIIHV-UHFFFAOYSA-N;   SMILES=OC=1C(Cl)=CNC(C1)=O;   Ts-1 (TN);   gimestat
 xref: CAS:103766-25-2;   Drug_Central:1293;   KEGG:D01846
 xref_mesh: MESH:C104201


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Gimeracil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd44 CD44 molecule multiple interactions EXP [gimeracil co-treated with Fluorouracil] results in decreased expression of CD44 CTD PMID:12364819 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions
decreases activity		 ISO DPYD results in increased susceptibility to [Fluorouracil co-treated with gimeracil]; gimeracil affects the reaction [DPYD protein results in increased susceptibility to Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in decreased susceptibility to Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in increased degradation of Fluorouracil]; gimeracil inhibits the reaction [DPYD protein results in increased metabolism of Fluorouracil]
gimeracil results in decreased activity of DPYD protein		 CTD PMID:12044515 PMID:15949589 PMID:15993511 PMID:17699726 PMID:19093184 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19819
          carbon atom 19772
            organic molecular entity 19772
              Gimeracil 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            Gimeracil 2
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