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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bradykinin
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Accession:CHEBI:3165 term browser browse the term
Definition:A linear nonapeptide messenger belonging to the kinin group of proteins, with amino acid sequence RPPGFSPFR. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation.
Synonyms:related_synonym: Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg;   BK;   Formula=C50H73N15O11;   InChI=1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1;   InChIKey=QXZGBUJJYSLZLT-FDISYFBBSA-N;   L-Arg-L-Pro-L-Pro-Gly-L-Phe-L-Ser-L-Pro-L-Phe-L-Arg;   L-arginyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanyl-L-arginine;   L-bradykinin;   RPPGFSPFR;   SMILES=N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
 xref: CAS:58-82-2
 xref_mesh: MESH:D001920
 xref: PMID:11799074;   PMID:11975815;   PMID:13446366;   PMID:13811230;   PMID:14597148;   PMID:15105283;   PMID:16680069;   PMID:18127230;   PMID:27318425;   PMID:27328010;   PMID:27432758;   PMID:27445816;   PMID:7859389;   PMID:8723398;   PMID:9403361;   Reaxys:24162492;   Reaxys:2801232;   Wikipedia:Bradykinin
 cyclic_relationship: is_conjugate_base_of CHEBI:132988


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bradykinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos3 nitric oxide synthase 3 decreases expression ISO Bradykinin results in decreased expression of NOS3 mRNA CTD PMID:24839774 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19867
    chemical entity 19865
      group 19818
        organic group 18984
          amino-acid residue 11445
            peptide 11445
              oligopeptide 1350
                bradykinin 1
                  NPC-567 0
                  [Hyp(3)]-bradykinin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    p-block element atom 19803
                      carbon group element atom 19744
                        carbon atom 19740
                          organic molecular entity 19740
                            heteroorganic entity 19512
                              organochalcogen compound 19273
                                organooxygen compound 19189
                                  carbon oxoacid 18660
                                    carboxylic acid 18657
                                      carboacyl group 17700
                                        univalent carboacyl group 17700
                                          carbamoyl group 17551
                                            carboxamide 17551
                                              peptide 11445
                                                oligopeptide 1350
                                                  bradykinin 1
                                                    NPC-567 0
                                                    [Hyp(3)]-bradykinin 0
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