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G |
Akr1a1 |
aldo-keto reductase family 1 member A1 |
multiple interactions |
ISO |
fidarestat inhibits the reaction [Glucose results in decreased expression of AKR1A1 mRNA] |
CTD |
PMID:16805838 |
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NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
multiple interactions affects binding |
ISO |
fidarestat binds to and results in decreased activity of AKR1B1 protein NADP binds to AKR1B1 protein binds to fidarestat |
CTD |
PMID:23295227 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Akr1b10 |
aldo-keto reductase family 1 member B10 |
affects binding multiple interactions |
ISO |
NADP binds to AKR1B10 protein mutant form binds to fidarestat fidarestat binds to and results in decreased activity of AKR1B10 protein mutant form |
CTD |
PMID:23295227 |
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NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] |
CTD |
PMID:22253906 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Il13 |
interleukin 13 |
multiple interactions decreases response to substance |
ISO |
fidarestat inhibits the reaction [IL13 protein results in increased expression of and results in increased secretion of MUC5AC protein]; fidarestat inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of JAK1 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK1 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK3 protein]; fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of STAT6 protein] fidarestat results in decreased susceptibility to IL13 protein fidarestat inhibits the reaction [Plant Extracts results in increased expression of IL13 mRNA] |
CTD |
PMID:21203431 |
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NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] |
CTD |
PMID:22253906 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] |
CTD |
PMID:22253906 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Jak1 |
Janus kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of JAK1 protein] fidarestat results in decreased phosphorylation of JAK1 protein |
CTD |
PMID:21203431 |
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NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK1 protein] fidarestat results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:21203431 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
decreases phosphorylation multiple interactions |
ISO |
fidarestat results in decreased phosphorylation of MAPK3 protein fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21203431 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Muc5ac |
mucin 5AC, oligomeric mucus/gel-forming |
multiple interactions |
ISO |
fidarestat inhibits the reaction [IL13 protein results in increased expression of and results in increased secretion of MUC5AC protein]; fidarestat inhibits the reaction [IL13 protein results in increased expression of MUC5AC mRNA] |
CTD |
PMID:21203431 |
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NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] |
CTD |
PMID:22253906 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Spdef |
SAM pointed domain containing ets transcription factor |
multiple interactions |
ISO |
fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF mRNA]; fidarestat inhibits the reaction [IL13 protein results in increased expression of SPDEF protein] |
CTD |
PMID:21203431 |
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NCBI chr20:5,771,440...5,785,893
Ensembl chr20:5,771,441...5,785,893
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G |
Stat6 |
signal transducer and activator of transcription 6 |
multiple interactions decreases phosphorylation |
ISO |
fidarestat inhibits the reaction [IL13 protein results in increased phosphorylation of STAT6 protein] fidarestat results in decreased phosphorylation of STAT6 protein fidarestat inhibits the reaction [Plant Extracts results in increased phosphorylation of STAT6 protein] |
CTD |
PMID:21203431 |
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NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; fidarestat inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
CTD |
PMID:22253906 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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