CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: dydrogesterone
Accession: CHEBI:31527
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Definition: A 3-oxo Delta(4)-steroid that has formula C21H28O2.
Synonyms: exact_synonym: 9beta,10alpha-pregna-4,6-diene-3,20-dione
related_synonym: 10alpha-Isopregnenone; 6-Dehydro-retro-progesterone; Formula=C21H28O2; Hydrogesterone; Hydrogestrone; InChI=1S/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4-5,12,16-19H,6-11H2,1-3H3/t16-,17+,18-,19+,20+,21+/m0/s1; InChIKey=JGMOKGBVKVMRFX-HQZYFCCVSA-N; Isopregnenone; Retro-6-dehydroprogesterone; SMILES=[H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@]1([H])[C@@]2([H])C=CC2=CC(=O)CC[C@@]12C; delta(6)-Retroprogesterone; delta(sup 6)-Retroprogesterone; didrogesterona; dydrogesteronum
xref: Beilstein:3121425; CAS:152-62-5; DrugBank:DB00378; Drug_Central:975; KEGG:D01217
xref_mesh: MESH:D004394
xref: Wikipedia:Dydrogesterone
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Akr1c1
aldo-keto reductase family 1, member C1
increases expression decreases expression decreases activity increases metabolic processing
ISO
Dydrogesterone results in increased expression of AKR1C1 mRNA Dydrogesterone results in decreased expression of AKR1C1 mRNA Dydrogesterone results in decreased activity of AKR1C1 protein AKR1C1 protein results in increased metabolism of Dydrogesterone
CTD
PMID:21182831 PMID:23183084
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c2
aldo-keto reductase family 1, member C2
decreases activity decreases expression
ISO
Dydrogesterone results in decreased activity of AKR1C2 protein Dydrogesterone results in decreased expression of AKR1C2 mRNA
CTD
PMID:22245609 PMID:23183084
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Akr1c3
aldo-keto reductase family 1, member C3
decreases activity decreases expression
ISO
Dydrogesterone results in decreased activity of AKR1C3 protein Dydrogesterone results in decreased expression of AKR1C3 mRNA
CTD
PMID:21182831 PMID:23183084
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
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Edn1
endothelin 1
multiple interactions
ISO
Dydrogesterone affects the reaction [Estradiol results in decreased expression of EDN1 protein]
CTD
PMID:12385860
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
decreases expression increases expression
ISO
Dydrogesterone results in decreased expression of HSD17B2 mRNA Dydrogesterone results in increased expression of HSD17B2 protein
CTD
PMID:23183084
NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
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Ifng
interferon gamma
decreases expression multiple interactions
ISO
Dydrogesterone results in decreased expression of IFNG protein Mifepristone inhibits the reaction [Dydrogesterone results in decreased expression of IFNG protein]
CTD
PMID:16045524
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il10
interleukin 10
increases expression
ISO
Dydrogesterone results in increased expression of IL10 protein
CTD
PMID:16389545
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il4
interleukin 4
increases expression multiple interactions
ISO
Dydrogesterone results in increased expression of IL4 protein Mifepristone inhibits the reaction [Dydrogesterone results in increased expression of IL4 protein]
CTD
PMID:16045524 PMID:16389545
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il6
interleukin 6
increases expression multiple interactions
ISO
Dydrogesterone results in increased expression of IL6 protein Mifepristone inhibits the reaction [Dydrogesterone results in increased expression of IL6 protein]
CTD
PMID:16045524
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Pgr
progesterone receptor
affects activity decreases expression
ISO
Dydrogesterone affects the activity of PGR protein Dydrogesterone results in decreased expression of PGR mRNA
CTD
PMID:16045524 PMID:23183084
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Pibf1
progesterone immunomodulatory binding factor 1
affects expression increases expression
ISO
Dydrogesterone affects the expression of PIBF1 protein Dydrogesterone results in increased expression of PIBF1 protein
CTD
PMID:15760377 PMID:16045524
NCBI chr15:75,850,389...76,019,711
Ensembl chr15:75,850,624...76,019,712
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Srd5a1
steroid 5 alpha-reductase 1
decreases expression
ISO
Dydrogesterone results in decreased expression of SRD5A1 mRNA
CTD
PMID:23183084
NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
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Tacr1
tachykinin receptor 1
decreases expression
ISO
Dydrogesterone results in decreased expression of TACR1 protein
CTD
PMID:16389545
NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
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Tnf
tumor necrosis factor
decreases expression multiple interactions
ISO
Dydrogesterone results in decreased expression of TNF protein Mifepristone inhibits the reaction [Dydrogesterone results in decreased expression of TNF protein]
CTD
PMID:16045524
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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