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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:clobazam
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Accession:CHEBI:31413 term browser browse the term
Definition:7-Chloro-1H-1,5-benzodiazepine-2,4(3H,5H)-dione in which the hydrogen attached to the nitrogen at position 1 is substituted by a methyl group, whilst that attached to the other nitrogen is substituted by a phenyl group. It is used for the short-term management of acute anxiety and as an adjunct in the treatment of epilepsy in association with other antiepileptics.
Synonyms:exact_synonym: 7-chloro-1-methyl-5-phenyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
 related_synonym: 1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepine;   7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione;   Formula=C16H13ClN2O2;   InChI=1S/C16H13ClN2O2/c1-18-13-8-7-11(17)9-14(13)19(16(21)10-15(18)20)12-5-3-2-4-6-12/h2-9H,10H2,1H3;   InChIKey=CXOXHMZGEKVPMT-UHFFFAOYSA-N;   SMILES=CN1C(=O)CC(=O)N(c2ccccc2)c2cc(Cl)ccc12;   clobazamum
 alt_id: CHEBI:211390
 xref: CAS:22316-47-8;   DrugBank:DB00349;   Drug_Central:682;   HMDB:HMDB0014493;   KEGG:D01253
 xref_mesh: MESH:C012255
 xref: PMID:11129898;   PMID:12873507;   PMID:16190747;   PMID:1977910;   PMID:19810886;   PMID:21982812;   PMID:22128252;   PMID:22145708;   PMID:22242724;   PMID:22293514;   PMID:22345881;   PMID:22383262;   PMID:22422635;   PMID:22449211;   PMID:22695038;   PMID:22727658;   PMID:22749457;   PMID:22883278;   PMID:22955137;   PMID:22964442;   PMID:22982618;   PMID:23006671;   Patent:BE707667;   Patent:US3984398;   Reaxys:758410;   Wikipedia:Clobazam


show annotations for term's descendants           Sort by:
clobazam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects response to substance EXP ABCC2 protein affects the susceptibility to clobazam CTD PMID:22982618 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Sele selectin E multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of SELE protein CTD PMID:16376047 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Serpinc1 serpin family C member 1 multiple interactions ISO [clobazam co-treated with Phenytoin] results in increased expression of [F2 protein binds to SERPINC1 protein] CTD PMID:16376047 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        biophysical role 14062
          membrane transport modulator 13900
            GABA modulator 5124
              clobazam 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            organic molecule 19724
                              organic cyclic compound 19515
                                organic heterocyclic compound 18890
                                  organonitrogen heterocyclic compound 18172
                                    benzodiazepine 926
                                      1,4-benzodiazepinone 126
                                        clobazam 4
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