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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cinnarizine
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Accession:CHEBI:31403 term browser browse the term
Definition:A N-alkylpiperazine that has formula C26H28N2.
Synonyms:exact_synonym: 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
 related_synonym: 1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine;   1-Benzhydryl-4-cinnamylpiperazin;   1-Cinnamyl-4-(diphenylmethyl)piperazine;   Formula=C26H28N2;   InChI=1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+;   InChIKey=DERZBLKQOCDDDZ-JLHYYAGUSA-N;   SMILES=C1CN(CCN1C\\C=C\\c1ccccc1)C(c1ccccc1)c1ccccc1;   cinarizina;   cinnarizinum
 xref: Beilstein:626121;   CAS:298-57-7;   Chemspider:1264793;   DrugBank:DB00568;   Drug_Central:654;   KEGG:D01295;   LINCS:LSM-42858
 xref_mesh: MESH:D002936
 xref: PMID:12609783;   PMID:24134630;   PMID:28386684;   PMID:28567501;   PMID:29175776;   PMID:29807074;   PMID:30322124;   PMID:30803454;   PMID:30868302;   PMID:31420703;   PMID:31707814;   PMID:31750127;   PMID:32597267;   PMID:32904111;   PMID:33359616;   PMID:33946152;   PMID:34466453;   PMID:7000939;   Patent:US2882271;   Wikipedia:Cinnarizine


show annotations for term's descendants           Sort by:
cinnarizine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Cinnarizine results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Drd2 dopamine receptor D2 affects binding
multiple interactions		 ISO
EXP		 Cinnarizine binds to DRD2 protein
Cinnarizine inhibits the reaction [nemonapride binds to DRD2 protein]		 CTD PMID:7503767 PMID:11180191 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase decreases response to substance ISO PRKN results in decreased susceptibility to Cinnarizine CTD PMID:15993444 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        pharmacological role 19122
          antagonist 17266
            histamine antagonist 4895
              cinnarizine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    main group molecular entity 19838
                      s-block molecular entity 19698
                        hydrogen molecular entity 19679
                          hydrides 19181
                            inorganic hydride 18192
                              pnictogen hydride 18157
                                nitrogen hydride 18070
                                  azane 17873
                                    ammonia 17898
                                      organic amino compound 17898
                                        tertiary amino compound 10158
                                          N-alkylpiperazine 3404
                                            cinnarizine 3
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