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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cilnidipine
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Accession:CHEBI:31399 term browser browse the term
Definition:A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.
Synonyms:exact_synonym: 2-methoxyethyl (2E)-3-phenylprop-2-en-1-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
 related_synonym: (+-)-(E)-cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate;   Formula=C27H28N2O7;   InChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+;   InChIKey=KJEBULYHNRNJTE-DHZHZOJOSA-N;   SMILES=COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC\\C=C\\c1ccccc1
 alt_id: CHEBI:551341
 xref: CAS:132203-70-4;   Drug_Central:642;   KEGG:D01173
 xref_mesh: MESH:C065927
 xref: Patent:EP161877;   Patent:US4672068;   Wikipedia:Cilnidipine


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cilnidipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO		 cilnidipine inhibits the reaction [Iohexol results in increased expression of BAX protein] CTD PMID:36207783 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP		 cilnidipine inhibits the reaction [Iohexol results in decreased expression of BCL2 protein] CTD PMID:36207783 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Camk2g calcium/calmodulin-dependent protein kinase II gamma multiple interactions ISO cilnidipine inhibits the reaction [CAMK2G protein promotes the reaction [Iohexol results in increased cleavage of CASP3 protein]] CTD PMID:36207783 NCBI chr15:3,504,017...3,563,050
Ensembl chr15:3,504,085...3,563,050 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 cilnidipine inhibits the reaction [CAMK2G protein promotes the reaction [Iohexol results in increased cleavage of CASP3 protein]]; cilnidipine inhibits the reaction [Iohexol results in increased cleavage of CASP3 protein] CTD PMID:36207783 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO cilnidipine results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794 		JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO cilnidipine results in decreased activity of ESR1 protein CTD PMID:25257666 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP cilnidipine results in decreased expression of FGF2 mRNA CTD PMID:16333380 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP cilnidipine inhibits the reaction [Iohexol results in increased expression of HAVCR1 protein] CTD PMID:36207783 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions EXP cilnidipine inhibits the reaction [Iohexol results in increased expression of LCN2 protein] CTD PMID:36207783 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO cilnidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
increases activity		 ISO cilnidipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; cilnidipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; cilnidipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
cilnidipine results in increased activity of NR1H4 protein		 CTD PMID:25257666 PMID:27773686 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases activity ISO cilnidipine results in decreased activity of PPARD protein CTD PMID:25257666 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases activity ISO cilnidipine results in decreased activity of PPARG protein CTD PMID:25257666 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppif peptidylprolyl isomerase F multiple interactions EXP
ISO		 cilnidipine inhibits the reaction [Iohexol results in increased expression of PPIF protein] CTD PMID:36207783 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP cilnidipine results in decreased expression of TGFB1 mRNA CTD PMID:16333380 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        solvent 17232
          2-methoxyethanol 377
            2-methoxyethyl ester 56
              cilnidipine 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      chalcogen 19563
                        oxygen atom 19535
                          oxygen molecular entity 19535
                            hydroxides 19341
                              organic hydroxy compound 18951
                                polyol 11690
                                  diol 3938
                                    glycol 3708
                                      glycol ether 939
                                        2-methoxyethanol 377
                                          2-methoxyethyl ester 56
                                            cilnidipine 15
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