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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carboplatin
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Accession:CHEBI:31355 term browser browse the term
Definition:A platinum coordination entity with cis square-planar geometry in which platinum(II) is coordinated to two ammonia ligands and a bidentate cyclobutane-1,1-dicarboxylate ligand.
Synonyms:exact_synonym: (SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum
 related_synonym: Formula=C6H12N2O4Pt;   Formula=C6H6O4Pt.2H3N;   InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2;   InChIKey=OLESAACUTLOWQZ-UHFFFAOYSA-L;   Paraplatin;   SMILES=[H][N]([H])([H])[Pt]1(OC(=O)C2(CCC2)C(=O)O1)[N]([H])([H])[H];   carboplatine;   carboplatino;   carboplatinum;   cbdca;   cis-(1,1-cyclobutanedicarboxylato)diammineplatinum(II);   cis-diammine(1,1-cyclobutanedicarboxylato)platinum;   cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II)
 alt_id: CHEBI:76407
 xref: CAS:41575-94-4;   DrugBank:DB00958;   Gmelin:1044703;   Gmelin:51428;   HMDB:HMDB0015093;   KEGG:D01363;   LINCS:LSM-4265
 xref_mesh: MESH:D016190
 xref: PDBeChem:QPT;   PMID:11666286;   PMID:14568240;   PMID:15896850;   PMID:16411667;   PMID:17180231;   PMID:17497898;   PMID:17655933;   PMID:18336396;   PMID:1855275;   PMID:19774597;   PMID:21629880;   PMID:22525758;   PMID:23143236;   PMID:23275170;   PMID:23396873;   PMID:24121332;   PMID:25195879;   PMID:25195881;   PMID:26000441;   PMID:26239545;   PMID:26327386;   PMID:26893290;   PMID:28511060;   PMID:29632935;   PMID:31567140;   PMID:31930743;   PMID:32072678;   PMID:32487607;   PMID:32579504;   PMID:33052033;   PMID:33324858;   PMID:33542435;   PMID:33716231;   PMID:33807309;   PMID:33814494;   PMID:33829940;   PMID:33885718;   PMID:9654475;   Patent:DE2329485;   Reaxys:11327310;   Reaxys:11335262;   Reaxys:15523471;   Wikipedia:Carboplatin


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carboplatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression ISO Carboplatin results in decreased expression of ABCB1 mRNA; Carboplatin results in decreased expression of ABCB1 protein CTD PMID:27692344 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression EXP Carboplatin results in decreased expression of ABCB4 mRNA CTD PMID:18172885 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases expression ISO Carboplatin results in decreased expression of ABCC1 mRNA; Carboplatin results in decreased expression of ABCC1 protein CTD PMID:27692344 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Carboplatin results in decreased expression of ABCC2 mRNA; Carboplatin results in decreased expression of ABCC2 protein CTD PMID:27692344 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression ISO Carboplatin results in decreased expression of ABCG2 mRNA; Carboplatin results in decreased expression of ABCG2 protein CTD PMID:27692344 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Acvr1c activin A receptor type 1C increases response to substance ISO ACVR1C results in increased susceptibility to Carboplatin CTD PMID:21224400 NCBI chr 3:42,815,490...42,892,423
Ensembl chr 3:42,822,610...42,892,327 		JBrowse link
G Ahr aryl hydrocarbon receptor decreases expression ISO Carboplatin results in decreased expression of AHR mRNA CTD PMID:36536508 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 increases expression EXP Carboplatin results in increased expression of AKR1B1 mRNA CTD PMID:18172885 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein]; Carboplatin promotes the reaction [Pulsatilla saponin A inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein]]; Pravastatin inhibits the reaction [Carboplatin results in increased activity of and results in increased phosphorylation of AKT1 protein]; Pulsatilla saponin A promotes the reaction [Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased phosphorylation of AKT1 protein]] CTD PMID:18483861 PMID:33190582 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 decreases expression EXP Carboplatin results in decreased expression of ALAS2 mRNA CTD PMID:21296123 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects response to substance ISO ALDH1A1 protein affects the susceptibility to Carboplatin CTD PMID:18854779 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 affects response to substance ISO ALDH3A1 protein affects the susceptibility to Carboplatin CTD PMID:18854779 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Anxa4 annexin A4 decreases response to substance
multiple interactions
affects localization		 ISO ANXA4 protein results in decreased susceptibility to Carboplatin
ATP7A protein promotes the reaction [ANXA4 protein results in decreased susceptibility to Carboplatin]
Carboplatin affects the localization of ANXA4 protein		 CTD PMID:24150977 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161 		JBrowse link
G Arfgef1 ADP ribosylation factor guanine nucleotide exchange factor 1 increases response to substance ISO ARFGEF1 results in increased susceptibility to Carboplatin CTD PMID:21755009 NCBI chr 5:8,982,061...9,076,326
Ensembl chr 5:8,981,540...9,076,326 		JBrowse link
G Arl4c ADP ribosylation factor like GTPase 4C affects response to substance ISO ARL4C protein affects the susceptibility to Carboplatin CTD PMID:36366750 NCBI chr 9:89,300,335...89,303,770
Ensembl chr 9:89,298,005...89,304,513 		JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 decreases expression EXP Carboplatin results in decreased expression of ATP1A1 mRNA CTD PMID:18172885 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
G Atp7a ATPase copper transporting alpha affects localization
multiple interactions		 ISO Carboplatin affects the localization of ATP7A protein
[MIR495 mRNA results in decreased expression of ATP7A protein] which results in increased susceptibility to Carboplatin; ATP7A protein promotes the reaction [ANXA4 protein results in decreased susceptibility to Carboplatin]		 CTD PMID:24038379 PMID:24150977 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354 		JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO ATP7B protein binds to and results in increased metabolism of Carboplatin CTD PMID:23751120 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
increases expression		 ISO Carboplatin results in decreased expression of BAX mRNA
[Carboplatin co-treated with Gallic Acid] results in increased expression of BAX protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of BAX protein; Carboplatin results in increased cleavage of and results in increased expression of BAX protein
Carboplatin results in increased expression of BAX mRNA; Carboplatin results in increased expression of BAX protein		 CTD PMID:15131059 PMID:15576332 PMID:33002289 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Carboplatin results in decreased expression of BCL2 mRNA; Carboplatin results in decreased expression of BCL2 protein CTD PMID:9664115 PMID:15576332 PMID:15996812 PMID:17404015 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions		 ISO
EXP		 Carboplatin results in decreased expression of BCL2L1 protein
Acetylcysteine inhibits the reaction [Carboplatin results in decreased expression of BCL2L1 protein]		 CTD PMID:18483861 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l12 Bcl2 like 12 increases expression ISO Carboplatin results in increased expression of BCL2L12 mRNA CTD PMID:15576332 NCBI chr 1:95,472,272...95,480,991
Ensembl chr 1:95,472,272...95,480,991 		JBrowse link
G Becn1 beclin 1 decreases expression
multiple interactions		 ISO Carboplatin results in decreased expression of BECN1 protein
Carboplatin promotes the reaction [Chloroquine results in decreased expression of BECN1 protein]; Chloroquine promotes the reaction [Carboplatin results in decreased expression of BECN1 protein]		 CTD PMID:27692344 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases response to substance ISO BIRC2 protein results in decreased susceptibility to Carboplatin CTD PMID:10815900 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Blmh bleomycin hydrolase decreases expression EXP Carboplatin results in decreased expression of BLMH mRNA CTD PMID:18172885 NCBI chr10:61,772,112...61,815,212
Ensembl chr10:61,758,478...61,815,212 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases activity ISO Carboplatin results in decreased activity of BRCA1 protein CTD PMID:20878461 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 affects response to substance ISO CAMKK2 protein affects the susceptibility to Carboplatin CTD PMID:28634229 NCBI chr12:33,791,023...33,845,000
Ensembl chr12:33,791,052...33,843,279 		JBrowse link
G Canx calnexin decreases expression EXP Carboplatin results in decreased expression of CANX mRNA CTD PMID:18172885 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821 		JBrowse link
G Casp2 caspase 2 decreases expression EXP Carboplatin results in decreased expression of CASP2 mRNA CTD PMID:18172885 NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 ISO
EXP		 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein]; [Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of CASP3 protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of CASP3 mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of CASP3 protein; Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein; palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP3 protein]
Carboplatin results in increased expression of CASP3 mRNA; Carboplatin results in increased expression of CASP3 protein
[Carboplatin co-treated with 1,2-Dimethylhydrazine] results in increased expression of CASP3 protein; Carboplatin promotes the reaction [[Pulsatilla saponin A co-treated with 1,2-Dimethylhydrazine] results in increased expression of CASP3 protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]; Pulsatilla saponin A promotes the reaction [[Carboplatin co-treated with 1,2-Dimethylhydrazine] results in increased expression of CASP3 protein]
Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]		 CTD PMID:15576332 PMID:16275998 PMID:18483861 PMID:20368269 PMID:22302033 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions		 ISO Carboplatin results in increased activity of CASP7 protein
palbociclib inhibits the reaction [Carboplatin results in increased activity of CASP7 protein]		 CTD PMID:22302033 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp9 caspase 9 increases activity
increases expression
multiple interactions
decreases expression		 ISO
EXP		 Carboplatin results in increased activity of CASP9 protein
Carboplatin results in increased expression of CASP9 protein
Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CASP9 protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP9 protein]
Carboplatin results in decreased expression of CASP9 mRNA		 CTD PMID:15576332 PMID:15996812 PMID:17404015 PMID:18483861 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity
multiple interactions
decreases expression		 EXP Carboplatin results in decreased activity of CAT protein
Carboplatin results in decreased expression of and results in decreased activity of CAT protein
Carboplatin results in decreased expression of CAT protein		 CTD PMID:11124453 PMID:15109710 PMID:15225673 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein]; Carboplatin promotes the reaction [Pulsatilla saponin A inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein]]; Pulsatilla saponin A promotes the reaction [Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CCND1 protein]] CTD PMID:33190582 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd274 CD274 molecule decreases expression ISO Carboplatin results in decreased expression of CD274; Carboplatin results in decreased expression of CD274 protein CTD PMID:21765211 PMID:27692344 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450 		JBrowse link
G Cd44 CD44 molecule decreases expression EXP Carboplatin results in decreased expression of CD44 mRNA CTD PMID:18172885 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cdc25b cell division cycle 25B decreases expression EXP Carboplatin results in decreased expression of CDC25B mRNA CTD PMID:21296123 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272 		JBrowse link
G Cdc42 cell division cycle 42 decreases expression EXP Carboplatin results in decreased expression of CDC42 mRNA CTD PMID:18172885 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO
EXP		 Carboplatin results in increased expression of CDKN1A protein
Carboplatin results in increased expression of CDKN1A mRNA		 CTD PMID:9664115 PMID:18172885 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression EXP Carboplatin results in increased expression of CITED2 mRNA CTD PMID:18172885 NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897 		JBrowse link
G Clu clusterin decreases expression EXP Carboplatin results in decreased expression of CLU mRNA CTD PMID:18172885 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cops5 COP9 signalosome subunit 5 increases response to substance ISO COPS5 results in increased susceptibility to Carboplatin CTD PMID:21755009 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Acetylcysteine inhibits the reaction [Carboplatin results in increased expression of CYCS protein]; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CYCS protein] CTD PMID:18483861 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Dct dopachrome tautomerase decreases response to substance ISO DCT protein results in decreased susceptibility to Carboplatin CTD PMID:15897911 NCBI chr15:95,062,006...95,100,863
Ensembl chr15:95,062,003...95,100,836 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Carboplatin results in increased expression of DDIT3 mRNA CTD PMID:18172885 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase multiple interactions ISO PCNA mRNA affects the reaction [DPYD mRNA affects the susceptibility to Carboplatin] CTD PMID:16685392 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha affects phosphorylation ISO Carboplatin affects the phosphorylation of EIF2S1 protein CTD PMID:29053414 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions ISO [Paclitaxel co-treated with Carboplatin] results in increased expression of EPCAM protein CTD PMID:12695858 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127 		JBrowse link
G Epo erythropoietin increases expression EXP Carboplatin results in increased expression of EPO protein CTD PMID:17891399 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO ERBB2 protein results in decreased susceptibility to [Cyclophosphamide co-treated with Thiotepa co-treated with Carboplatin] CTD PMID:16446318 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Carboplatin results in increased expression of FAS mRNA CTD PMID:15576332 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fshb follicle stimulating hormone subunit beta increases expression EXP Carboplatin results in increased expression of FSHB protein CTD PMID:8776818 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Carboplatin results in decreased activity of GSR protein CTD PMID:11124453 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects response to substance ISO GSTP1 gene affects the susceptibility to Carboplatin CTD PMID:12360105 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions
increases phosphorylation		 ISO Carboplatin results in increased expression of H2AX protein
palbociclib inhibits the reaction [Carboplatin results in increased expression of H2AX protein]; phellopterin promotes the reaction [[Carboplatin results in increased phosphorylation of H2AX protein] which results in increased susceptibility to Carboplatin]; phellopterin promotes the reaction [Carboplatin results in increased phosphorylation of H2AX protein]		 CTD PMID:22302033 PMID:37708916 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hax1 HCLS1 associated protein X-1 multiple interactions EXP Pravastatin inhibits the reaction [Carboplatin results in decreased expression of HAX1 protein] CTD PMID:18483861 NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714 		JBrowse link
G Hbb hemoglobin subunit beta decreases expression EXP Carboplatin results in decreased expression of HBB mRNA CTD PMID:21296123 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
decreases expression
decreases response to substance
increases expression		 ISO
EXP		 HMOX1 protein inhibits the reaction [Carboplatin results in increased activity of NFATC4]
Carboplatin results in decreased expression of HMOX1 mRNA
HMOX1 protein results in decreased susceptibility to Carboplatin
Carboplatin results in increased expression of HMOX1 mRNA		 CTD PMID:18172885 PMID:20368269 PMID:21198546 PMID:26260164 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression EXP Carboplatin results in decreased expression of HSD17B4 mRNA CTD PMID:18172885 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression EXP Carboplatin results in increased expression of HSPA1A mRNA CTD PMID:18172885 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression EXP Carboplatin results in increased expression of HSPA1B mRNA CTD PMID:18172885 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression EXP Carboplatin results in decreased expression of HSPA5 mRNA CTD PMID:18172885 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression EXP Carboplatin results in increased expression of HSPB1 mRNA CTD PMID:18172885 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Igf2r insulin-like growth factor 2 receptor decreases expression EXP Carboplatin results in decreased expression of IGF2R mRNA CTD PMID:18172885 NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501 		JBrowse link
G Il6 interleukin 6 decreases response to substance ISO IL6 protein results in decreased susceptibility to Carboplatin CTD PMID:7834629 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor decreases response to substance ISO IL6R protein results in decreased susceptibility to Carboplatin CTD PMID:7834629 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Carboplatin results in decreased expression of JUN mRNA CTD PMID:18172885 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions ISO [Paclitaxel co-treated with Carboplatin] results in decreased expression of KLK3 protein CTD PMID:16442593 NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 decreases expression EXP Carboplatin results in decreased expression of MAP3K1 mRNA CTD PMID:18172885 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463 		JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 decreases expression EXP Carboplatin results in decreased expression of MAP3K12 mRNA CTD PMID:18172885 NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression EXP Carboplatin results in decreased expression of MAPK14 mRNA CTD PMID:18172885 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk6 mitogen-activated protein kinase 6 decreases expression EXP Carboplatin results in decreased expression of MAPK6 mRNA CTD PMID:18172885 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression EXP Carboplatin results in decreased expression of MGMT mRNA CTD PMID:18172885 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mir155 microRNA 155 multiple interactions ISO [Carboplatin co-treated with Chloroquine] results in increased expression of MIR155 mRNA CTD PMID:27692344 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]; Carboplatin promotes the reaction [Pulsatilla saponin A inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]]; Pulsatilla saponin A promotes the reaction [Carboplatin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]] CTD PMID:33190582 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [Carboplatin co-treated with Carnitine deficiency] results in increased expression of MPO protein CTD PMID:18852009 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Msh2 mutS homolog 2 decreases expression EXP Carboplatin results in decreased expression of MSH2 mRNA CTD PMID:18172885 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Mt1 metallothionein 1 decreases expression
increases expression		 EXP
ISO		 Carboplatin results in decreased expression of MT1A mRNA
Carboplatin results in increased expression of MT1A mRNA		 CTD PMID:18172885 PMID:35027733 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases response to substance ISO MYC protein results in increased susceptibility to Carboplatin CTD PMID:21324178 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nanog Nanog homeobox increases expression ISO Carboplatin results in increased expression of NANOG mRNA CTD PMID:25605917 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Nbas NBAS subunit of NRZ tethering complex affects response to substance ISO NBAS intron polymorphism affects the susceptibility to Carboplatin CTD PMID:21844884 NCBI chr 6:36,048,357...36,353,206
Ensembl chr 6:36,048,191...36,352,984 		JBrowse link
G Nckap1 NCK-associated protein 1 decreases expression EXP Carboplatin results in decreased expression of NCKAP1 mRNA CTD PMID:18172885 NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 multiple interactions
increases activity		 ISO
EXP		 HMOX1 protein inhibits the reaction [Carboplatin results in increased activity of NFATC4] CTD PMID:21198546 NCBI chr15:29,286,998...29,314,610
Ensembl chr15:29,305,535...29,314,610 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases expression		 ISO
EXP		 Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]; Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]]
Carboplatin results in decreased expression of NFKB1 mRNA		 CTD PMID:12675310 PMID:18172885 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation
multiple interactions		 ISO Carboplatin results in decreased phosphorylation of NFKBIA protein
NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]]		 CTD PMID:12675310 PMID:15120608 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nodal nodal growth differentiation factor increases response to substance ISO NODAL results in increased susceptibility to Carboplatin CTD PMID:21224400 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP Carboplatin results in increased expression of NQO1 mRNA CTD PMID:18172885 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nras NRAS proto-oncogene, GTPase decreases expression EXP Carboplatin results in decreased expression of NRAS mRNA CTD PMID:18172885 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Or4d6 olfactory receptor family 4 subfamily D member 6 affects response to substance ISO OR4D6 gene SNP affects the susceptibility to Carboplatin CTD PMID:26378035 NCBI chr 1:209,039,073...209,040,017
Ensembl chr 1:209,037,992...209,045,985 		JBrowse link
G Osm oncostatin M increases expression ISO Carboplatin results in increased expression of OSM mRNA CTD PMID:36536508 NCBI chr14:79,103,638...79,108,500
Ensembl chr14:79,104,344...79,108,313 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Carboplatin results in increased cleavage of PARP1 protein CTD PMID:15996812 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pawr pro-apoptotic WT1 regulator decreases expression EXP Carboplatin results in decreased expression of PAWR mRNA CTD PMID:18172885 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression		 ISO
EXP		 PCNA mRNA affects the reaction [DPYD mRNA affects the susceptibility to Carboplatin]; PCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Carboplatin]
Carboplatin results in increased expression of PCNA mRNA		 CTD PMID:16685392 PMID:18172885 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdcd1lg2 programmed cell death 1 ligand 2 decreases expression
multiple interactions		 ISO Carboplatin results in decreased expression of PDCD1LG2
STAT6 gene mutant form inhibits the reaction [Carboplatin results in decreased expression of PDCD1LG2]		 CTD PMID:21765211 NCBI chr 1:227,158,941...227,223,938
Ensembl chr 1:227,158,941...227,223,938 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 decreases expression EXP Carboplatin results in decreased expression of PDIA4 mRNA CTD PMID:18172885 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 decreases expression EXP Carboplatin results in decreased expression of PDIA6 mRNA CTD PMID:18172885 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Carboplatin results in increased expression of PMAIP1 protein CTD PMID:20802529 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Prkd2 protein kinase D2 affects response to substance ISO PRKD2 protein affects the susceptibility to Carboplatin CTD PMID:37951334 NCBI chr 1:77,513,625...77,542,386
Ensembl chr 1:77,513,986...77,542,376 		JBrowse link
G Psmb2 proteasome 20S subunit beta 2 increases expression EXP Carboplatin results in increased expression of PSMB2 mRNA CTD PMID:18172885 NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137 		JBrowse link
G Psmb4 proteasome 20S subunit beta 4 decreases expression EXP Carboplatin results in decreased expression of PSMB4 mRNA CTD PMID:18172885 NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases response to substance
multiple interactions		 ISO PTGS2 protein results in decreased susceptibility to Carboplatin
wortmannin inhibits the reaction [PTGS2 protein results in decreased susceptibility to Carboplatin]		 CTD PMID:18089846 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rab10 RAB10, member RAS oncogene family decreases expression EXP Carboplatin results in decreased expression of RAB10 mRNA CTD PMID:18172885 NCBI chr 6:26,267,081...26,319,739
Ensembl chr 6:26,266,859...26,320,193 		JBrowse link
G Rbm17 RNA binding motif protein 17 decreases response to substance ISO RBM17 protein results in decreased susceptibility to Carboplatin CTD PMID:16061639 NCBI chr17:66,937,140...66,954,034
Ensembl chr17:66,937,140...66,954,014 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Carboplatin results in decreased localization of and results in decreased activity of RELA protein; Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]; NFKBIA gene mutant form inhibits the reaction [Carboplatin results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:12675310 PMID:15120608 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 decreases expression EXP Carboplatin results in decreased expression of SCD2 mRNA CTD PMID:18172885 NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232 		JBrowse link
G Sik1 salt-inducible kinase 1 increases response to substance ISO SIK1 results in increased susceptibility to Carboplatin CTD PMID:21755009 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 decreases response to substance
increases response to substance
increases uptake
increases import
multiple interactions		 ISO
EXP		 SLC31A1 gene mutant form results in decreased susceptibility to Carboplatin
SLC31A1 protein results in increased susceptibility to Carboplatin
SLC31A1 protein results in increased uptake of Carboplatin
SLC31A1 protein results in increased import of Carboplatin
[Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [tetrathiomolybdate results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin		 CTD PMID:15634647 PMID:16847145 PMID:19509135 PMID:22914438 PMID:23123662 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228 		JBrowse link
G Slc31a2 solute carrier family 31 member 2 decreases uptake ISO SLC31A2 protein results in decreased uptake of Carboplatin CTD PMID:19509135 NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542 		JBrowse link
G Smo smoothened, frizzled class receptor increases expression ISO Carboplatin results in increased expression of SMO mRNA CTD PMID:25605917 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression		 EXP Carboplatin results in decreased expression of and results in decreased activity of SOD1 protein
Carboplatin results in decreased expression of SOD1 protein		 CTD PMID:15109710 PMID:15225673 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression		 EXP Carboplatin results in increased expression of and results in increased activity of SOD2 protein
Carboplatin results in decreased expression of SOD2 protein		 CTD PMID:15109710 PMID:15225673 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression ISO Carboplatin results in increased expression of SOX2 mRNA CTD PMID:25605917 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO STAT6 gene mutant form inhibits the reaction [Carboplatin results in decreased expression of PDCD1LG2] CTD PMID:21765211 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Stk39 serine threonine kinase 39 decreases expression EXP Carboplatin results in decreased expression of STK39 mRNA CTD PMID:18172885 NCBI chr 3:52,913,583...53,179,060
Ensembl chr 3:52,913,585...53,179,060 		JBrowse link
G Stx2 syntaxin 2 increases response to substance ISO STX2 protein results in increased susceptibility to Carboplatin CTD PMID:24039787 NCBI chr12:27,678,744...27,714,751
Ensembl chr12:27,689,819...27,714,751 		JBrowse link
G Tfap2a transcription factor AP-2 alpha increases response to substance ISO TFAP2A protein results in increased susceptibility to Carboplatin CTD PMID:16204029 NCBI chr17:24,028,716...24,047,507
Ensembl chr17:24,024,432...24,047,507 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Carboplatin co-treated with Carnitine deficiency] results in increased expression of TNF protein CTD PMID:18852009 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO TOP2A results in decreased susceptibility to [Carboplatin co-treated with Etoposide co-treated with Ifosfamide] CTD PMID:11325482 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO Carboplatin results in increased expression of TP53 mRNA; Carboplatin results in increased expression of TP53 protein
[Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 protein; [Gallic Acid co-treated with Carboplatin] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of TP53 protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of TP53 mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of TP53 protein		 CTD PMID:9664115 PMID:15131059 PMID:33002289 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tyms thymidylate synthetase multiple interactions ISO PCNA mRNA affects the reaction [TYMS mRNA affects the susceptibility to Carboplatin] CTD PMID:16685392 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases expression EXP Carboplatin results in decreased expression of UGT1A6 mRNA CTD PMID:18172885 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vim vimentin decreases expression EXP Carboplatin results in decreased expression of VIM mRNA CTD PMID:18172885 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Xdh xanthine dehydrogenase affects activity EXP Carboplatin affects the activity of XDH protein CTD PMID:15225673 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor decreases response to substance ISO XPC results in decreased susceptibility to Carboplatin CTD PMID:19372135 NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010 		JBrowse link
G Zfp36l1 zinc finger protein 36, C3H type-like 1 decreases expression EXP Carboplatin results in decreased expression of ZFP36L1 mRNA CTD PMID:18172885 NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        aetiopathogenetic role 19250
          genotoxin 17684
            mutagen 17575
              carboplatin 125
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    p-block element atom 19849
                      carbon group element atom 19766
                        carbon atom 19785
                          organic molecular entity 19785
                            organic ion 11438
                              organic anion 6852
                                carboxylic acid anion 2502
                                  dicarboxylic acid anion 252
                                    dicarboxylic acid dianion 252
                                      cyclobutanedicarboxylate 125
                                        cyclobutane-1,1-dicarboxylate(2-) 125
                                          carboplatin 125
paths to the root