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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benzethonium chloride
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Accession:CHEBI:31264 term browser browse the term
Definition:A (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. An antiseptic and disinfectant, it is active against a broad spectrum of bacteria, fungi, moulds and viruses.
Synonyms:exact_synonym: N-benzyl-N,N-dimethyl-2-{2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethanaminium chloride
 related_synonym: Anti-germ 77;   Antiseptol;   BZT;   Banagerm;   Diapp;   Disilyn;   Formula=C27H42ClNO2;   Hyamine;   Hyamine 1622;   InChI=1S/C27H42NO2.ClH/c1-26(2,3)22-27(4,5)24-13-15-25(16-14-24)30-20-19-29-18-17-28(6,7)21-23-11-9-8-10-12-23;/h8-16H,17-22H2,1-7H3;1H/q+1;/p-1;   InChIKey=UREZNYTWGJKWBI-UHFFFAOYSA-M;   Inactisol;   Kylacol;   Microklenz;   N,N-dimethyl-N-(2-{2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy}ethyl)-benzenemethanaminium chloride;   Neostelin green;   Phemeride;   Phemerol chloride;   Phemithyn;   Polymine D;   QAC;   Quatrachlor;   SMILES=[Cl-].CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1;   Salanine;   Sanizol;   Solamin;   Solamine;   benzethonii chloridum;   benzetonium chloride;   benzyldimethyl(2-{2-[4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy}ethyl)ammonium chloride;   benzyldimethyl(2-{2-[p-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy}ethyl)ammonium chloride;   benzyldimethyl-p-(1,1,3,3-tetramethylbutyl)phenoxyethoxy-ethylammonium chloride;   chlorure de benzethonium;   cloruro de benzetonio;   diisobutylphenoxyethoxyethyl dimethyl benzyl ammonium chloride;   diisobutylphenoxyethoxyethyldimethyl benzyl ammonium chloride;   p-diisobutyl phenoxyethoxyethyl dimethyl benzylammonium chloride;   p-tert-octylphenoxyethoxyethyldimethylbenzylammonium chloride;   {2-[2-(4-diisobutylphenoxy)ethoxy]ethyl}dimethylbenzylammonium chloride
 xref: CAS:121-54-0;   KEGG:C12539;   KEGG:D01140
 xref_mesh: MESH:D001558
 xref: PMID:11453769;   PMID:11606328;   PMID:12595925;   PMID:16750419;   PMID:17867553;   PMID:22828255;   PMID:2310164;   PMID:2735743;   PMID:3416474;   PMID:3995765;   Patent:US2115250;   Wikipedia:3898548;   Wikipedia:Benzethonium_chloride


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benzethonium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 increases expression ISO Benzethonium results in increased expression of ALDH1L2 mRNA CTD PMID:37149095 NCBI chr 7:20,254,246...20,305,793
Ensembl chr 7:20,254,233...20,305,776 		JBrowse link
G Arrdc4 arrestin domain containing 4 decreases expression ISO Benzethonium results in decreased expression of ARRDC4 mRNA CTD PMID:37149095 NCBI chr 1:122,369,355...122,383,351
Ensembl chr 1:122,369,360...122,383,290 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Benzethonium results in increased expression of ASNS mRNA CTD PMID:37149095 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Benzethonium results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression ISO Benzethonium results in decreased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Benzethonium results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Benzethonium results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 increases expression ISO Benzethonium results in increased expression of CHAC1 mRNA CTD PMID:37149095 NCBI chr 3:106,342,302...106,345,526
Ensembl chr 3:106,342,302...106,345,526 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Benzethonium results in increased expression of DDIT3 mRNA CTD PMID:37149095 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO Benzethonium results in increased expression of DDIT4 mRNA CTD PMID:37149095 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Benzethonium results in increased expression of HERPUD1 mRNA CTD PMID:37149095 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Benzethonium co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ighg1 immunoglobulin heavy constant gamma 1 decreases expression ISO Benzethonium results in decreased expression of IGHG1 mRNA CTD PMID:37149095 Ensembl chr 6:132,389,370...132,393,397 JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Benzethonium results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Benzethonium co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Benzethonium results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO Benzethonium results in increased expression of INSIG1 mRNA CTD PMID:37149095 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952 		JBrowse link
G Kcna3 potassium voltage-gated channel subfamily A member 3 decreases activity
multiple interactions		 ISO Benzethonium results in decreased activity of KCNA3 protein
[Benzethonium results in decreased activity of KCNA3 protein] which results in decreased import of Thallium		 CTD PMID:21362439 NCBI chr 2:194,632,106...194,634,059
Ensembl chr 2:194,632,196...194,650,138 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity		 ISO [Benzethonium results in decreased activity of KCNH2 protein] which results in decreased import of Thallium CTD PMID:21362439 PMID:23313619 PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Benzethonium results in increased expression of LDLR mRNA CTD PMID:37149095 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G LOC120102574 U6 spliceosomal RNA increases expression ISO Benzethonium results in increased expression of RNU6-1014P CTD PMID:37149095 NCBI chr 4:102,735,624...102,735,728
Ensembl chr 4:102,735,624...102,735,728 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Benzethonium results in increased expression of NR4A2 mRNA CTD PMID:37149095 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression ISO Benzethonium results in increased expression of PSAT1 mRNA CTD PMID:37149095 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682 		JBrowse link
G Rnu6-767 RNA, U6 small nuclear 767 decreases expression ISO Benzethonium results in decreased expression of RNU6-767P CTD PMID:37149095 NCBI chr 2:102,241,494...102,241,597
Ensembl chr 2:102,241,494...102,241,597 		JBrowse link
G Sesn2 sestrin 2 increases expression ISO Benzethonium results in increased expression of SESN2 mRNA CTD PMID:37149095 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Benzethonium inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Benzethonium results in increased expression of SLC7A11 mRNA CTD PMID:37149095 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Benzethonium results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      biological role 19866
        antimicrobial agent 18260
          antiviral agent 11341
            benzethonium chloride 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    main group molecular entity 19835
                      s-block molecular entity 19670
                        hydrogen molecular entity 19651
                          hydrides 19158
                            inorganic hydride 18176
                              pnictogen hydride 18166
                                nitrogen hydride 18079
                                  ammonium 8322
                                    ammonium ion derivative 8317
                                      ammonium compound 5205
                                        organoammonium salt 671
                                          quaternary ammonium salt 553
                                            benzethonium chloride 28
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