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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5,5-diethylbarbituric acid
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Accession:CHEBI:31252 term browser browse the term
Definition:A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by two ethyl groups. Formerly used as a hypnotic (sleeping aid).
Synonyms:related_synonym: 2,4,6(1H,3H,5H)-pyrimidinetrione;   5,5-Diethyl-pyrimidine-2,4,6-trione;   5,5-diethylpyrimidine-2,4,6(1H,3H,5H)-trione;   Barbital;   Barbitone;   DEBA;   Formula=C8H12N2O3;   InChI=1S/C8H12N2O3/c1-3-8(4-2)5(11)9-7(13)10-6(8)12/h3-4H2,1-2H3,(H2,9,10,11,12,13);   InChIKey=FTOAOBMCPZCFFF-UHFFFAOYSA-N;   SMILES=CCC1(CC)C(=O)NC(=O)NC1=O;   Veronal;   diethylmalonyl urea
 alt_id: CHEBI:102256
 xref: CAS:57-44-3;   DrugBank:DB01483;   Drug_Central:289;   Gmelin:4113;   KEGG:D01740
 xref_mesh: MESH:D001462
 xref: PMID:10866370;   PMID:15857133;   PMID:17827020;   PMID:20681553;   PMID:22467201;   PMID:3654008;   PMID:6864729;   Reaxys:163999;   Wikipedia:Barbital


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5,5-diethylbarbituric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase increases activity
increases expression		 ISO Barbital results in increased activity of ALAD protein
Barbital results in increased expression of ALAD mRNA		 CTD PMID:16309571 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Bche butyrylcholinesterase decreases activity ISO Barbital results in decreased activity of BCHE protein CTD PMID:11929041 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity EXP Barbital results in increased activity of CYP2B1 protein CTD PMID:7697745 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Barbital results in increased expression of HMOX1 mRNA CTD PMID:16309571 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            drug allergen 11849
              5,5-diethylbarbituric acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic heterocyclic compound 18868
                                  organic heteromonocyclic compound 17791
                                    diazines 13215
                                      pyrimidines 13085
                                        pyrimidone 10512
                                          barbiturates 4627
                                            5,5-diethylbarbituric acid 4
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