CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: alclometasone dipropionate
Accession: CHEBI:31184
browse the term
Definition: A prednisolone compound having an alpha-chloro substituent at the 7-position, an alpha-methyl substituent at the 16-position and O-propanoyl groups at the 17- and 21-positions.
Synonyms: exact_synonym: (7alpha,11beta,16alpha)-7-chloro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate
related_synonym: Formula=C28H37ClO7; InChI=1S/C28H37ClO7/c1-6-22(33)35-14-21(32)28(36-23(34)7-2)15(3)10-18-24-19(29)12-16-11-17(30)8-9-26(16,4)25(24)20(31)13-27(18,28)5/h8-9,11,15,18-20,24-25,31H,6-7,10,12-14H2,1-5H3/t15-,18+,19-,20+,24-,25+,26+,27+,28+/m1/s1; InChIKey=DJHCCTTVDRAMEH-DUUJBDRPSA-N; SMILES=[H][C@@]12C[C@@H](C)[C@](OC(=O)CC)(C(=O)COC(=O)CC)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])[C@H](Cl)CC2=CC(=O)C=C[C@]12C
xref: Beilstein:6493669; CAS:66734-13-2; DrugBank:DB00240; Drug_Central:4493; KEGG:D01820
xref_mesh: MESH:C021137
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Ccl2
C-C motif chemokine ligand 2
decreases expression
ISO
alclometasone dipropionate results in decreased expression of CCL2 protein
CTD
PMID:20116850
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl3
C-C motif chemokine ligand 3
increases expression
ISO
alclometasone dipropionate results in increased expression of CCL3 protein
CTD
PMID:20116850
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl4
C-C motif chemokine ligand 4
increases expression
ISO
alclometasone dipropionate results in increased expression of CCL4 protein
CTD
PMID:20116850
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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Csf2
colony stimulating factor 2
decreases expression
ISO
alclometasone dipropionate results in decreased expression of CSF2 protein
CTD
PMID:11407316
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Ifng
interferon gamma
decreases expression
ISO
alclometasone dipropionate results in decreased expression of IFNG protein
CTD
PMID:11407316
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il2
interleukin 2
decreases expression
ISO
alclometasone dipropionate results in decreased expression of IL2 protein
CTD
PMID:11407316
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il3
interleukin 3
decreases expression
ISO
alclometasone dipropionate results in decreased expression of IL3 protein
CTD
PMID:11407316
NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
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Il4
interleukin 4
decreases expression
ISO
alclometasone dipropionate results in decreased expression of IL4 protein
CTD
PMID:11407316
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il5
interleukin 5
decreases expression
ISO
alclometasone dipropionate results in decreased expression of IL5 protein
CTD
PMID:11407316
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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Vegfa
vascular endothelial growth factor A
decreases expression
ISO
alclometasone dipropionate results in decreased expression of VEGFA protein
CTD
PMID:20116850
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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