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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spiramycin II
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Accession:CHEBI:31168 term browser browse the term
Definition:A macrolide antibiotic produced by various Streptomyces species.
Synonyms:exact_synonym: (4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-10-{[(2R,5S,6S)-5-(dimethylamino)-6-methyloxan-2-yl]oxy}-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-4-yl acetate
 related_synonym: Acetylspiramycin;   Acetylspiramycinum;   Formula=C45H76N2O15;   Foromacidin B;   Foromacidine B;   InChI=1S/C45H76N2O15/c1-25-22-31(20-21-48)41(62-44-39(51)38(47(10)11)40(28(4)58-44)61-37-24-45(7,53)43(52)29(5)57-37)42(54-12)34(59-30(6)49)23-35(50)55-26(2)16-14-13-15-17-33(25)60-36-19-18-32(46(8)9)27(3)56-36/h13-15,17,21,25-29,31-34,36-44,51-53H,16,18-20,22-24H2,1-12H3/b14-13+,17-15+/t25-,26-,27+,28-,29+,31+,32+,33+,34-,36+,37+,38-,39-,40-,41+,42+,43+,44+,45-/m1/s1;   InChIKey=ZPCCSZFPOXBNDL-RSMXASMKSA-N;   SMILES=CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\\C=C\\C=C\\[C@H](O[C@H]2CC[C@@H]([C@H](C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@@H]([C@H]1O)N(C)C)OC(C)=O;   Spiramycin 2;   Spiramycin B
 xref: CAS:24916-51-6;   KEGG:C12891;   KEGG:D02420;   LIPID_MAPS_instance:LMPK05000002
 xref_mesh: MESH:C033163
 xref: PMID:15127585;   PMID:16496680;   PMID:20843520;   PMID:2232146;   PMID:23866271;   PMID:24790408;   PMID:25081985;   PMID:25164320;   PMID:3793330;   PMID:4077347;   PMID:6655800;   PMID:7154255;   PMID:7321185;   PMID:7321187;   Patent:WO2011147316;   Reaxys:25081792



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spiramycin II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO acetylspiramycin results in increased expression of FOS mRNA; acetylspiramycin results in increased expression of FOS protein CTD PMID:32454074 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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  CHEBI ontology 19878
    role 19848
      biological role 19846
        antimicrobial agent 18242
          spiramycin II 1
Path 2
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  CHEBI ontology 19878
    subatomic particle 19876
      composite particle 19876
        hadron 19876
          baryon 19876
            nucleon 19876
              atomic nucleus 19876
                atom 19876
                  main group element atom 19815
                    p-block element atom 19815
                      carbon group element atom 19755
                        carbon atom 19752
                          organic molecular entity 19752
                            heteroorganic entity 19509
                              organochalcogen compound 19270
                                organooxygen compound 19186
                                  carbon oxoacid 18654
                                    carboxylic acid 18651
                                      carboacyl group 17694
                                        univalent carboacyl group 17694
                                          formyl group 9049
                                            aldehyde 9049
                                              spiramycin II 1
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