CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: spiramycin II
Accession: CHEBI:31168
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Definition: A macrolide antibiotic produced by various Streptomyces species.
Synonyms: exact_synonym: (4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-{[(2S,3R,4R,5S,6R)-5-{[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-10-{[(2R,5S,6S)-5-(dimethylamino)-6-methyloxan-2-yl]oxy}-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-4-yl acetate
related_synonym: Acetylspiramycin; Acetylspiramycinum; Formula=C45H76N2O15; Foromacidin B; Foromacidine B; InChI=1S/C45H76N2O15/c1-25-22-31(20-21-48)41(62-44-39(51)38(47(10)11)40(28(4)58-44)61-37-24-45(7,53)43(52)29(5)57-37)42(54-12)34(59-30(6)49)23-35(50)55-26(2)16-14-13-15-17-33(25)60-36-19-18-32(46(8)9)27(3)56-36/h13-15,17,21,25-29,31-34,36-44,51-53H,16,18-20,22-24H2,1-12H3/b14-13+,17-15+/t25-,26-,27+,28-,29+,31+,32+,33+,34-,36+,37+,38-,39-,40-,41+,42+,43+,44+,45-/m1/s1; InChIKey=ZPCCSZFPOXBNDL-RSMXASMKSA-N; SMILES=CO[C@H]1[C@@H](CC(=O)O[C@H](C)C\\C=C\\C=C\\[C@H](O[C@H]2CC[C@@H]([C@H](C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]1O[C@H](C)[C@@H](O[C@H]2C[C@@](C)(O)[C@@H](O)[C@H](C)O2)[C@@H]([C@H]1O)N(C)C)OC(C)=O; Spiramycin 2; Spiramycin B
xref: CAS:24916-51-6; KEGG:C12891; KEGG:D02420; LIPID_MAPS_instance:LMPK05000002
xref_mesh: MESH:C033163
xref: PMID:15127585; PMID:16496680; PMID:20843520; PMID:2232146; PMID:23866271; PMID:24790408; PMID:25081985; PMID:25164320; PMID:3793330; PMID:4077347; PMID:6655800; PMID:7154255; PMID:7321185; PMID:7321187; Patent:WO2011147316; Reaxys:25081792
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
acetylspiramycin results in increased expression of FOS mRNA; acetylspiramycin results in increased expression of FOS protein
CTD
PMID:32454074
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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