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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trichloroacetic acid
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Accession:CHEBI:30956 term browser browse the term
Definition:A monocarboxylic acid that is acetic acid in which all three methyl hydrogens are substituted by chlorine.
Synonyms:related_synonym: Formula=C2HCl3O2;   InChI=1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7);   InChIKey=YNJBWRMUSHSURL-UHFFFAOYSA-N;   SMILES=OC(=O)C(Cl)(Cl)Cl;   TCA;   Trichloressigsaeure;   trichloracetic acid;   trichloroethanoic acid
 alt_id: CHEBI:27095;   CHEBI:9684
 xref: Beilstein:970119;   CAS:76-03-9;   Drug_Central:3627;   Gmelin:2842;   KEGG:C11150;   KEGG:D08633
 xref_mesh: MESH:D014238
 xref: MetaCyc:CPD-9675;   PMID:12573897;   PMID:16298895;   PMID:16815816;   PMID:16901594;   PMID:21269351;   PMID:21332915;   PMID:21457391;   PMID:21497335;   PMID:21523508;   PMID:21529453;   PMID:21549800;   PMID:21716542;   Reaxys:970119;   Wikipedia:Trichloroacetic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:27455


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trichloroacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A increases expression ISO Trichloroacetic Acid results in increased expression of ACAA1A mRNA CTD PMID:23575800 NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624 		JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain increases expression ISO Trichloroacetic Acid results in increased expression of ACADL mRNA CTD PMID:23575800 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression ISO Trichloroacetic Acid results in increased expression of ACOT1 mRNA CTD PMID:23575800 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163 		JBrowse link
G Acox1 acyl-CoA oxidase 1 increases expression ISO Trichloroacetic Acid results in increased expression of ACOX1 mRNA CTD PMID:23575800 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression EXP Trichloroacetic Acid results in increased expression of ATP2A2 mRNA CTD PMID:14565619 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G C1qbp complement C1q binding protein decreases expression EXP Trichloroacetic Acid results in decreased expression of C1QBP mRNA CTD PMID:14565619 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649 		JBrowse link
G Casp3 caspase 3 decreases cleavage
multiple interactions		 EXP Trichloroacetic Acid results in decreased cleavage of CASP3 protein
[diacerein co-treated with Fluorouracil] inhibits the reaction [Trichloroacetic Acid results in decreased cleavage of CASP3 protein]; diacerein inhibits the reaction [Trichloroacetic Acid results in decreased cleavage of CASP3 protein]		 CTD PMID:34794354 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cd69 Cd69 molecule multiple interactions ISO [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD69 protein CTD PMID:26343699 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542 		JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression ISO Trichloroacetic Acid results in increased expression of CPT2 mRNA CTD PMID:23575800 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [CYP2E1 protein results in increased oxidation of Tetrachloroethylene] which results in increased abundance of Trichloroacetic Acid; [CYP2E1 protein results in increased oxidation of Trichloroethylene] which results in increased abundance of Trichloroacetic Acid CTD PMID:29897530 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO Trichloroacetic Acid results in increased expression of EHHADH mRNA CTD PMID:23575800 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression
multiple interactions		 EXP Trichloroacetic Acid results in increased expression of GPT protein
diacerein inhibits the reaction [Trichloroacetic Acid results in increased expression of GPT protein]		 CTD PMID:34794354 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression		 EXP [diacerein co-treated with Fluorouracil] inhibits the reaction [Trichloroacetic Acid results in increased expression of HIF1A protein]; diacerein inhibits the reaction [Trichloroacetic Acid results in increased expression of HIF1A protein]; Fluorouracil inhibits the reaction [Trichloroacetic Acid results in increased expression of HIF1A protein] CTD PMID:34794354 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Trichloroacetic Acid results in increased expression of HMOX1 mRNA CTD PMID:31755747 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 decreases expression EXP Trichloroacetic Acid results in decreased expression of HSPE1 mRNA CTD PMID:14565619 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA CTD PMID:26343699 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf2 insulin-like growth factor 2 decreases methylation ISO Trichloroacetic Acid results in decreased methylation of IGF2 gene CTD PMID:15036762 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Il10 interleukin 10 decreases secretion ISO Trichloroacetic Acid results in decreased secretion of IL10 protein CTD PMID:29953848 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO
EXP		 Trichloroacetic Acid results in increased expression of IL1B protein
[diacerein co-treated with Fluorouracil] inhibits the reaction [Trichloroacetic Acid results in increased expression of IL1B protein]; diacerein inhibits the reaction [Trichloroacetic Acid results in increased expression of IL1B protein]		 CTD PMID:29953848 PMID:34794354 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA; [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein CTD PMID:26343699 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions ISO [Trichloroacetic Acid co-treated with Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA protein CTD PMID:26343699 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Il6 interleukin 6 increases expression ISO Trichloroacetic Acid results in increased expression of IL6 protein CTD PMID:29953848 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases methylation
increases expression		 ISO [Trichloroacetic Acid results in decreased methylation of JUN promoter] which results in increased expression of JUN mRNA; Methionine inhibits the reaction [[Trichloroacetic Acid results in decreased methylation of JUN promoter] which results in increased expression of JUN mRNA]; Methionine inhibits the reaction [Trichloroacetic Acid results in increased expression of JUN protein] CTD PMID:10774822 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mpo myeloperoxidase increases activity ISO Trichloroacetic Acid results in increased activity of MPO protein CTD PMID:20391627 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases methylation		 ISO [Trichloroacetic Acid results in decreased methylation of MYC promoter] which results in increased expression of MYC mRNA; Methionine inhibits the reaction [[Trichloroacetic Acid results in decreased methylation of MYC promoter] which results in increased expression of MYC mRNA]; Methionine inhibits the reaction [Trichloroacetic Acid results in increased expression of MYC protein]
Trichloroacetic Acid results in increased expression of MYC mRNA; Trichloroacetic Acid results in increased expression of MYC protein
Trichloroacetic Acid results in decreased methylation of MYC gene; Trichloroacetic Acid results in decreased methylation of MYC promoter		 CTD PMID:10774822 PMID:11284051 PMID:11532874 PMID:16014735 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression
multiple interactions		 ISO
EXP		 Trichloroacetic Acid results in increased expression of PCNA protein
[diacerein co-treated with Fluorouracil] inhibits the reaction [Trichloroacetic Acid results in increased expression of PCNA protein]; diacerein inhibits the reaction [Trichloroacetic Acid results in increased expression of PCNA protein]; Fluorouracil inhibits the reaction [Trichloroacetic Acid results in increased expression of PCNA protein]		 CTD PMID:11284051 PMID:34794354 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
affects activity		 ISO Trichloroacetic Acid results in increased activity of PPARA protein
Trichloroacetic Acid affects the activity of PPARA protein		 CTD PMID:9703482 PMID:10581215 PMID:23575800 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Rps10 ribosomal protein S10 decreases expression EXP Trichloroacetic Acid results in decreased expression of RPS10 mRNA CTD PMID:14565619 NCBI chr20:5,694,313...5,698,922
Ensembl chr20:5,694,313...5,699,044
Ensembl chr 6:5,694,313...5,699,044 		JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A increases expression EXP Trichloroacetic Acid results in increased expression of SDHA mRNA CTD PMID:14565619 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Trichloroacetic Acid results in increased expression of TNF protein
Trichloroacetic Acid results in increased expression of and results in decreased secretion of TNF protein		 CTD PMID:20391627 PMID:29953848 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
increases expression		 EXP [diacerein co-treated with Fluorouracil] inhibits the reaction [Trichloroacetic Acid results in increased expression of VEGFA protein]; diacerein inhibits the reaction [Trichloroacetic Acid results in increased expression of VEGFA protein] CTD PMID:34794354 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        biochemical role 19596
          metabolite 19558
            trichloroacetic acid 31
              TCA-ethadyl 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            heteroorganic entity 19556
                              organochalcogen compound 19315
                                organooxygen compound 19205
                                  carbon oxoacid 18694
                                    carboxylic acid 18691
                                      monocarboxylic acid 18007
                                        acetic acid 11092
                                          trichloroacetic acid 31
                                            TCA-ethadyl 0
paths to the root