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G |
Akr1b1 |
aldo-keto reductase family 1 member B1 |
multiple interactions increases abundance |
ISO |
AKR1B1 protein promotes the reaction [Glucose results in increased abundance of Sorbitol] AKR1B1 protein results in increased abundance of Sorbitol |
CTD |
PMID:25451566 PMID:25541468 |
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NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
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G |
Alox5 |
arachidonate 5-lipoxygenase |
multiple interactions |
ISO |
[Sorbitol co-treated with Calcimycin co-treated with Arachidonic Acid] affects the localization of ALOX5 protein; SB 203580 inhibits the reaction [Sorbitol results in increased activity of ALOX5 protein]; Sorbitol results in increased phosphorylation of and results in increased activity of ALOX5 protein |
CTD |
PMID:10779545 PMID:11698504 |
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NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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G |
Aqp9 |
aquaporin 9 |
multiple interactions increases uptake |
ISO EXP |
Sorbitol inhibits the reaction [AQP9 protein results in increased uptake of arsenite] AQP9 protein results in increased uptake of Sorbitol |
CTD |
PMID:9733774 PMID:19341753 |
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NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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G |
Bola2 |
bolA family member 2 |
increases expression |
ISO |
Sorbitol results in increased expression of BOLA2 mRNA |
CTD |
PMID:35678645 |
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NCBI chr 1:181,291,967...181,292,833
Ensembl chr 1:181,291,398...181,292,676
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G |
Caprin1 |
cell cycle associated protein 1 |
multiple interactions |
ISO |
Sorbitol promotes the reaction [SNRNP200 protein binds to CAPRIN1 protein] |
CTD |
PMID:33939924 |
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NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
EXP |
Sorbitol results in increased activity of CASP3 protein Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP3 protein] |
CTD |
PMID:20609311 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases activity multiple interactions |
EXP |
Sorbitol results in increased activity of CASP8 protein Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP8 protein] |
CTD |
PMID:20609311 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
increases activity multiple interactions |
EXP |
Sorbitol results in increased activity of CASP9 protein Spironolactone inhibits the reaction [Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein]]; Testosterone inhibits the reaction [Sorbitol results in increased activity of CASP9 protein] |
CTD |
PMID:20609311 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccna1 |
cyclin A1 |
decreases expression |
ISO |
Sorbitol results in decreased expression of CCNA1 mRNA |
CTD |
PMID:35678645 |
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NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
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G |
Ccnf |
cyclin F |
increases expression |
ISO |
Sorbitol results in increased expression of CCNF mRNA |
CTD |
PMID:35678645 |
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NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
Sorbitol results in decreased expression of CDK1 mRNA |
CTD |
PMID:35678645 |
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NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Chkb |
choline kinase beta |
decreases expression |
ISO |
Sorbitol results in decreased expression of CHKB mRNA |
CTD |
PMID:35678645 |
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NCBI chr 7:120,500,960...120,504,359
Ensembl chr 7:120,500,984...120,504,461
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G |
Crk |
CRK proto-oncogene, adaptor protein |
increases phosphorylation |
EXP |
Sorbitol results in increased phosphorylation of CRK protein |
CTD |
PMID:16187300 |
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NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
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G |
Ddb1 |
damage-specific DNA binding protein 1 |
increases expression |
ISO |
Sorbitol results in increased expression of DDB1 mRNA |
CTD |
PMID:35678645 |
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NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676
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G |
Eef1d |
eukaryotic translation elongation factor 1 delta |
increases expression |
ISO |
Sorbitol results in increased expression of EEF1D mRNA |
CTD |
PMID:35678645 |
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NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799
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G |
Eif3h |
eukaryotic translation initiation factor 3, subunit H |
decreases expression |
ISO |
Sorbitol results in decreased expression of EIF3H mRNA |
CTD |
PMID:35678645 |
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NCBI chr 7:83,091,037...83,174,451
Ensembl chr 7:83,091,039...83,174,451
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
multiple interactions |
ISO |
Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] |
CTD |
PMID:9545260 |
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NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
multiple interactions |
ISO |
Sorbitol promotes the reaction [EIF4E protein binds to EIF4EBP1 protein] |
CTD |
PMID:9545260 |
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NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Eny2 |
ENY2, transcription and export complex 2 subunit |
increases expression |
ISO |
Sorbitol results in increased expression of ENY2 mRNA |
CTD |
PMID:35678645 |
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NCBI chr 7:75,581,215...75,605,903
Ensembl chr 7:75,581,240...75,605,897
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G |
Fmr1 |
fragile X messenger ribonucleoprotein 1 |
increases abundance |
ISO |
FMR1 5' UTR mutant form results in increased abundance of Sorbitol |
CTD |
PMID:27385396 |
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NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050
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G |
Ins1 |
insulin 1 |
multiple interactions |
EXP |
Sorbitol promotes the reaction [Glucose results in increased secretion of INS1 protein] |
CTD |
PMID:10221768 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases phosphorylation |
ISO |
JNK-IN-8 inhibits the reaction [Sorbitol results in increased phosphorylation of JUN protein] |
CTD |
PMID:24184208 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Mapk10 |
mitogen activated protein kinase 10 |
multiple interactions increases activity |
ISO |
Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein] |
CTD |
PMID:10531305 |
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NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
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G |
Mapk12 |
mitogen-activated protein kinase 12 |
increases phosphorylation |
ISO |
Sorbitol results in increased phosphorylation of MAPK12 protein |
CTD |
PMID:15362974 |
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NCBI chr 7:120,206,005...120,216,711
Ensembl chr 7:120,206,271...120,216,664
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G |
Mapk14 |
mitogen activated protein kinase 14 |
increases phosphorylation |
ISO |
Sorbitol results in increased phosphorylation of MAPK14 protein |
CTD |
PMID:15362974 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk7 |
mitogen-activated protein kinase 7 |
increases activity |
ISO |
Sorbitol results in increased activity of MAPK7 protein |
CTD |
PMID:11163183 |
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NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
increases phosphorylation |
ISO |
Sorbitol results in increased phosphorylation of MAPK8 protein |
CTD |
PMID:24184208 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
increases phosphorylation |
ISO |
Sorbitol results in increased phosphorylation of MAPK9 protein |
CTD |
PMID:24184208 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mapkapk2 |
MAPK activated protein kinase 2 |
increases activity increases phosphorylation multiple interactions |
ISO |
Sorbitol results in increased activity of MAPKAPK2 protein Sorbitol results in increased phosphorylation of MAPKAPK2 protein SB 203580 inhibits the reaction [Sorbitol results in increased phosphorylation of MAPKAPK2 protein] |
CTD |
PMID:9545260 PMID:15362974 |
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NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
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G |
Mknk1 |
MAPK interacting serine/threonine kinase 1 |
increases activity |
ISO |
Sorbitol results in increased activity of MKNK1 protein |
CTD |
PMID:9545260 |
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NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639
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G |
Mrps16 |
mitochondrial ribosomal protein S16 |
decreases expression |
ISO |
Sorbitol results in decreased expression of MRPS16 mRNA |
CTD |
PMID:35678645 |
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NCBI chr15:3,918,621...3,921,024
Ensembl chr15:3,918,615...3,921,656
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G |
Oat |
ornithine aminotransferase |
multiple interactions |
EXP |
Sorbitol inhibits the reaction [Cyclic AMP results in increased activity of OAT protein] |
CTD |
PMID:2827574 |
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NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
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G |
Ppt1 |
palmitoyl-protein thioesterase 1 |
increases expression |
ISO |
Sorbitol results in increased expression of PPT1 mRNA |
CTD |
PMID:35678645 |
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NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048
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G |
Pten |
phosphatase and tensin homolog |
affects localization |
ISO EXP |
Sorbitol affects the localization of PTEN protein |
CTD |
PMID:16807353 |
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NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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G |
Rpl18 |
ribosomal protein L18 |
increases expression |
ISO |
Sorbitol results in increased expression of RPL18 mRNA |
CTD |
PMID:35678645 |
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NCBI chr 1:96,188,811...96,191,452
Ensembl chr 1:96,188,112...96,191,452
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G |
Snrnp200 |
small nuclear ribonucleoprotein U5 subunit 200 |
multiple interactions |
ISO |
Sorbitol promotes the reaction [SNRNP200 protein binds to CAPRIN1 protein] |
CTD |
PMID:33939924 |
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NCBI chr 3:114,428,854...114,458,194
Ensembl chr 3:114,428,854...114,458,182
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G |
Sord |
sorbitol dehydrogenase |
multiple interactions increases abundance increases metabolic processing |
ISO |
[SORD protein results in increased metabolism of Sorbitol] which results in increased abundance of Fructose; epalrestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol]; ranirestat inhibits the reaction [SORD protein mutant form results in increased abundance of Sorbitol] |
CTD |
PMID:32367058 |
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NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133
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G |
Tardbp |
TAR DNA binding protein |
increases ubiquitination |
ISO |
Sorbitol results in increased ubiquitination of TARDBP protein |
CTD |
PMID:31780563 |
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NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
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G |
Tk1 |
thymidine kinase 1 |
increases expression |
ISO |
Sorbitol results in increased expression of TK1 mRNA |
CTD |
PMID:35678645 |
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NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
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G |
Ube2c |
ubiquitin-conjugating enzyme E2C |
decreases expression |
ISO |
Sorbitol results in decreased expression of UBE2C mRNA |
CTD |
PMID:35678645 |
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NCBI chr 3:153,506,636...153,509,036
Ensembl chr 3:153,506,636...153,513,339
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G |
Ubxn1 |
UBX domain protein 1 |
increases phosphorylation |
ISO |
Sorbitol results in increased phosphorylation of UBXN1 protein |
CTD |
PMID:15362974 |
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NCBI chr 1:205,765,309...205,769,234
Ensembl chr 1:205,745,120...205,816,520
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
Isosorbide Dinitrate results in decreased activity of CYP1A1 protein |
CTD |
PMID:33814510 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Edn1 |
endothelin 1 |
multiple interactions |
ISO |
[Isosorbide Dinitrate co-treated with Plant Preparations] results in decreased expression of EDN1 mRNA |
CTD |
PMID:15719745 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
decreases response to substance |
ISO |
G6PD protein results in decreased susceptibility to Isosorbide Dinitrate |
CTD |
PMID:6401899 |
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NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
[Isosorbide Dinitrate co-treated with Ascorbic Acid] affects the expression of NOS3 mRNA; [Isosorbide Dinitrate co-treated with Plant Preparations] results in increased expression of NOS3 mRNA |
CTD |
PMID:15719745 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Pafah1b1 |
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 |
multiple interactions |
EXP |
isosorbide-5-mononitrate inhibits the reaction [Castor Oil results in increased expression of PAFAH1B1 protein] |
CTD |
PMID:8738301 |
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NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808
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