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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methylmalonic acid
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Accession:CHEBI:30860 term browser browse the term
Definition:A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
Synonyms:exact_synonym: methylpropanedioic acid
 related_synonym: 1,1-Ethanedicarboxylic acid;   2-methylmalonic acid;   Formula=C4H6O4;   InChI=1S/C4H6O4/c1-2(3(5)6)4(7)8/h2H,1H3,(H,5,6)(H,7,8);   InChIKey=ZIYVHBGGAOATLY-UHFFFAOYSA-N;   Isosuccinic acid;   SMILES=CC(C(O)=O)C(O)=O;   alpha-methylmalonic acid
 alt_id: CHEBI:25319;   CHEBI:42270;   CHEBI:6881
 xref: CAS:516-05-2;   DrugBank:DB04183;   Gmelin:50008;   HMDB:HMDB0000202;   KEGG:C02170;   LIPID_MAPS_instance:LMFA01170118
 xref_mesh: MESH:D008764
 xref: MetaCyc:CPD-546;   PDBeChem:DXX;   PMID:11673368;   PMID:15770414;   PMID:17190852;   PMID:21478039;   PMID:21652239;   PMID:21687976;   PMID:21748409;   PMID:21802231;   PMID:21896502;   PMID:22104738;   PMID:22233538;   PMID:22301932;   PMID:22332180;   PMID:22377700;   PMID:22422209;   PMID:22424943;   PMID:22509143;   PMID:22537172;   PMID:22770225;   Reaxys:1756084;   Wikipedia:Methylmalonic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:30861


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methylmalonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 multiple interactions
increases expression 		EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of AIF1 protein] CTD PMID:28223158 NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression 		EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL1B protein] CTD PMID:28223158 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression 		EXP pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of IL6 protein] CTD PMID:28223158 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Methylmalonic Acid CTD PMID:20567778 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions 		EXP Methylmalonic Acid results in increased expression of NOS2 protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of NOS2 protein] 		CTD PMID:28223158 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions 		EXP Methylmalonic Acid results in increased expression of TNF protein
pimagedine inhibits the reaction [Methylmalonic Acid results in increased expression of TNF protein] 		CTD PMID:28223158 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        biochemical role 20264
          metabolite 20245
            eukaryotic metabolite 19958
              animal metabolite 19803
                mammalian metabolite 19802
                  human metabolite 19220
                    methylmalonic acid 6
                      O-methylmalonyl-L-carnitine 0
                      aryl(methyl)malonic acid + 0
                      methylmalonyl-CoA + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbonyl compound 19440
                                    dicarboxylic acids and O-substituted derivatives 12725
                                      dicarboxylic acid 12722
                                        alpha,omega-dicarboxylic acid 3182
                                          malonic acid 68
                                            methylmalonic acid 6
                                              O-methylmalonyl-L-carnitine 0
                                              aryl(methyl)malonic acid + 0
                                              methylmalonyl-CoA + 0
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