Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:betamethasone
go back to main search page
Accession:CHEBI:3077 term browser browse the term
Definition:A glucocorticoid that has formula C22H29FO5.
Synonyms:exact_synonym: 9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
 related_synonym: 16beta-Methyl-1,4-pregnadiene-9alpha-fluoro-11beta,17alpha,21-triol-3,20-dione;   9-Fluoro-16beta-methylprednisolone;   9alpha-Fluoro-16beta-methylprednisolone;   Betadexamethasone;   Formula=C22H29FO5;   InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1;   InChIKey=UREBDLICKHMUKA-DVTGEIKXSA-N;   Rinderon;   SMILES=[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C;   beta-Methasone alcohol;   betametasona;   betamethasonum
 xref: Beilstein:3176546;   CAS:378-44-9;   DrugBank:DB00443;   Drug_Central:348;   KEGG:D00244
 xref_mesh: MESH:D001623
 xref: Patent:US3053865;   Patent:US3104246;   VSDB:1854;   Wikipedia:Betamethasone


show annotations for term's descendants           Sort by:
betamethasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp4 aquaporin 4 increases expression EXP Betamethasone results in increased expression of AQP4 mRNA CTD PMID:9409467 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Ar androgen receptor multiple interactions ISO Betamethasone binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Betamethasone results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Betamethasone results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Betamethasone results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Egr1 early growth response 1 affects expression ISO Betamethasone affects the expression of EGR1 mRNA CTD PMID:23461915 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Fshb follicle stimulating hormone subunit beta decreases expression EXP Betamethasone results in decreased expression of FSHB protein CTD PMID:27132128 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Fxn frataxin increases expression ISO Betamethasone results in increased expression of FXN mRNA CTD PMID:23418481 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO Betamethasone results in increased expression of and results in increased activity of HPGD protein CTD PMID:15680906 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
increases metabolic processing		 EXP
ISO		 Betamethasone inhibits the reaction [HSD11B2 protein affects the metabolism of Corticosterone]
HSD11B2 protein results in increased metabolism of Betamethasone		 CTD PMID:16549198 PMID:19490994 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 increases expression ISO Betamethasone results in increased expression of HSD17B4 mRNA CTD PMID:29901742 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Lhb luteinizing hormone subunit beta increases expression EXP Betamethasone results in increased expression of LHB protein CTD PMID:27132128 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
affects binding
increases activity		 ISO NR3C1 protein alternative form inhibits the reaction [Betamethasone results in increased activity of NR3C1 protein alternative form]
Betamethasone binds to NR3C1 protein		 CTD PMID:15362971 PMID:15755863 PMID:16507850 PMID:21543282 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Betamethasone results in increased activity of NR3C2 protein CTD PMID:15362971 NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Betamethasone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
betamethasone dipropionate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO betamethasone-17,21-dipropionate inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
betamethasone valerate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd40 CD40 molecule decreases expression ISO Betamethasone Valerate results in decreased expression of CD40 protein CTD PMID:15940147 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd83 CD83 molecule decreases expression ISO Betamethasone Valerate results in decreased expression of CD83 protein CTD PMID:15940147 NCBI chr17:20,887,309...20,907,009
Ensembl chr17:20,887,309...20,907,083 		JBrowse link
G Cd86 CD86 molecule decreases expression ISO Betamethasone Valerate results in decreased expression of CD86 protein CTD PMID:15940147 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO Betamethasone Valerate results in decreased expression of CSF2 protein CTD PMID:11407316 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Ifng interferon gamma decreases expression ISO Betamethasone Valerate results in decreased expression of IFNG protein CTD PMID:11407316 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2 interleukin 2 decreases expression ISO Betamethasone Valerate results in decreased expression of IL2 protein CTD PMID:11407316 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il3 interleukin 3 decreases expression ISO Betamethasone Valerate results in decreased expression of IL3 protein CTD PMID:11407316 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066 		JBrowse link
G Il4 interleukin 4 decreases expression ISO Betamethasone Valerate results in decreased expression of IL4 protein CTD PMID:11407316 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 decreases expression ISO Betamethasone Valerate results in decreased expression of IL5 protein CTD PMID:11407316 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      application 19695
        anti-asthmatic agent 9314
          betamethasone 25
            betamethasone acetate 0
            betamethasone acibutate 0
            betamethasone dipropionate + 1
            betamethasone phosphate 0
            betamethasone valerate 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbonyl compound 18914
                                    ketone 17263
                                      oxo steroid 10532
                                        3-oxo steroid 9922
                                          3-oxo-Delta(1) steroid 5224
                                            3-oxo-Delta(1),Delta(4)-steroid 5224
                                              betamethasone 25
                                                betamethasone acetate 0
                                                betamethasone acibutate 0
                                                betamethasone dipropionate + 1
                                                betamethasone phosphate 0
                                                betamethasone valerate 9
paths to the root