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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oxaloacetic acid
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Accession:CHEBI:30744 term browser browse the term
Definition:An oxodicarboxylic acid that is succinic acid bearing a single oxo group.
Synonyms:related_synonym: 2-Oxobutanedioic acid;   2-oxosuccinic acid;   3-carboxy-3-oxopropanoic acid;   Formula=C4H4O5;   InChI=1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9);   InChIKey=KHPXUQMNIQBQEV-UHFFFAOYSA-N;   OAA;   Oxalacetic acid;   Oxosuccinic acid;   SMILES=OC(=O)CC(=O)C(O)=O;   keto-succinic acid;   ketosuccinic acid;   oxobutanedioic acid
 alt_id: CHEBI:24959;   CHEBI:25734;   CHEBI:7812
 xref: CAS:328-42-7;   Gmelin:1042886;   HMDB:HMDB0000223;   KEGG:C00036;   KNApSAcK:C00001197;   LIPID_MAPS_instance:LMFA01170061
 xref_mesh: MESH:D062907
 xref: MetaCyc:OXALACETIC_ACID;   PDBeChem:OAA;   PMID:15710237;   PMID:17190852;   PMID:19793063;   PMID:21825143;   PMID:22451473;   PMID:28322963;   PMID:4014670;   PMID:8422384;   Patent:US2011064679;   Reaxys:1705475;   Wikipedia:Oxaloacetic_acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:16452


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oxaloacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions
decreases abundance		 ISO PF-06840003 inhibits the reaction [APP protein mutant form results in decreased abundance of Oxaloacetic Acid] CTD PMID:39172838 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Oxaloacetic Acid results in increased expression of GOT1 mRNA CTD PMID:26811028 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression ISO Oxaloacetic Acid results in increased expression of MDH1 protein CTD PMID:26811028 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II increases expression ISO Oxaloacetic Acid results in increased expression of COX2 mRNA; Oxaloacetic Acid results in increased expression of COX2 protein CTD PMID:26811028 NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1A mRNA; Oxaloacetic Acid results in increased expression of PPARGC1A protein CTD PMID:23056435 PMID:26811028 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1B protein CTD PMID:26811028 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Pprc1 PPARG related coactivator 1 increases expression ISO Oxaloacetic Acid results in increased expression of PPRC1 mRNA; Oxaloacetic Acid results in increased expression of PPRC1 protein CTD PMID:26811028 NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Oxaloacetic Acid results in increased expression of and results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Oxaloacetic Acid results in increased expression of TFAM mRNA CTD PMID:26811028 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        biochemical role 19556
          metabolite 19544
            oxaloacetic acid 9
              oxaloacetic acid 4-methyl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            heteroorganic entity 19512
                              organochalcogen compound 19275
                                organooxygen compound 19191
                                  carbonyl compound 18914
                                    dicarboxylic acids and O-substituted derivatives 11132
                                      dicarboxylic acid 11126
                                        alpha,omega-dicarboxylic acid 3173
                                          succinic acid 712
                                            oxaloacetic acid 9
                                              oxaloacetic acid 4-methyl ester 0
paths to the root