CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: beryllium atom
Accession: CHEBI:30501
browse the term
Definition: Alkaline earth metal atom with atomic number 4.
Synonyms: related_synonym: 4Be; Be; Formula=Be; InChI=1S/Be; InChIKey=ATBAMAFKBVZNFJ-UHFFFAOYSA-N; SMILES=[Be]; berilio; beryllium
xref: CAS:7440-41-7; Gmelin:16265
xref_mesh: MESH:D001608
xref: PMID:10858219; PMID:11897645; PMID:14643414; PMID:16951350; PMID:18250483; PMID:18768897; PMID:24912188; Reaxys:14617151; WebElements:Be
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
multiple interactions
EXP
[Beryllium results in increased methylation of CDKN2A promoter] which results in decreased expression of CDKN2A mRNA
CTD
PMID:11872642
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Esr1
estrogen receptor 1
increases methylation
EXP
Beryllium results in increased methylation of ESR1 gene
CTD
PMID:11872642
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Hras
HRas proto-oncogene, GTPase
increases mutagenesis
EXP
Beryllium results in increased mutagenesis of HRAS gene
CTD
PMID:7545909
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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Il1b
interleukin 1 beta
increases expression affects expression
ISO
Beryllium results in increased expression of IL1B mRNA Beryllium affects the expression of IL1B mRNA
CTD
PMID:8473757 PMID:8629860
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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RT1-Hb-ps1
RT1 class II, locus Hb, pseudogene 1
affects binding increases response to substance
ISO
HLA-DPB1 protein mutant form binds to Beryllium HLA-DPB1 gene polymorphism results in increased susceptibility to Beryllium; HLA-DPB1 gene SNP results in increased susceptibility to Beryllium; HLA-DPB1 protein mutant form results in increased susceptibility to Beryllium
CTD
PMID:11551429 PMID:15273960 PMID:17956852
NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,774,650...4,780,618
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Tnf
tumor necrosis factor
increases response to substance increases secretion increases expression
ISO
TNF promoter polymorphism results in increased susceptibility to Beryllium Beryllium results in increased secretion of TNF protein Beryllium results in increased expression of TNF mRNA
CTD
PMID:8629860 PMID:12449171 PMID:15127972
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
affects expression
ISO
beryllium chloride affects the expression of APEX1 mRNA
CTD
PMID:23793613
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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Ogg1
8-oxoguanine DNA glycosylase
affects expression
ISO
beryllium chloride affects the expression of OGG1 mRNA
CTD
PMID:23793613
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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Tp53
tumor protein p53
increases expression
ISO
beryllium chloride results in increased expression of TRP53 mRNA
CTD
PMID:23793613
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
beryllium fluoride promotes the reaction [ABCB1 protein mutant form binds to 8-azidoadenosine 5'-triphosphate]
CTD
PMID:11027628
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcc6
ATP binding cassette subfamily C member 6
multiple interactions
EXP
beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]; Cobalt promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]; Magnesium Chloride promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]; Manganese promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]; Nickel promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]
CTD
PMID:12069597
NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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Abcc8
ATP binding cassette subfamily C member 8
decreases activity
ISO EXP
beryllium fluoride results in decreased activity of ABCC8 protein
CTD
PMID:17561960 PMID:18025464
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
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Creb1
cAMP responsive element binding protein 1
increases expression
ISO
beryllium fluoride results in increased expression of CREB1 protein
CTD
PMID:11867686
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
beryllium fluoride results in increased expression of FOS protein
CTD
PMID:11867686
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Map2k1
mitogen activated protein kinase kinase 1
increases phosphorylation
ISO
beryllium fluoride results in increased phosphorylation of MAP2K1 protein
CTD
PMID:11867686
NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
beryllium fluoride results in increased phosphorylation of MAPK3 protein
CTD
PMID:11867686
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Myc
MYC proto-oncogene, bHLH transcription factor
increases expression
ISO
beryllium fluoride results in increased expression of MYC protein
CTD
PMID:11867686
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
multiple interactions
EXP
[Beryllium results in increased methylation of CDKN2A promoter] which results in decreased expression of CDKN2A mRNA
CTD
PMID:11872642
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Esr1
estrogen receptor 1
increases methylation
EXP
Beryllium results in increased methylation of ESR1 gene
CTD
PMID:11872642
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Hras
HRas proto-oncogene, GTPase
increases mutagenesis
EXP
Beryllium results in increased mutagenesis of HRAS gene
CTD
PMID:7545909
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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Il1b
interleukin 1 beta
increases expression affects expression
ISO
Beryllium results in increased expression of IL1B mRNA Beryllium affects the expression of IL1B mRNA
CTD
PMID:8473757 PMID:8629860
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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RT1-Hb-ps1
RT1 class II, locus Hb, pseudogene 1
affects binding increases response to substance
ISO
HLA-DPB1 protein mutant form binds to Beryllium HLA-DPB1 gene polymorphism results in increased susceptibility to Beryllium; HLA-DPB1 gene SNP results in increased susceptibility to Beryllium; HLA-DPB1 protein mutant form results in increased susceptibility to Beryllium
CTD
PMID:11551429 PMID:15273960 PMID:17956852
NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,774,650...4,780,618
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Tnf
tumor necrosis factor
increases expression increases response to substance increases secretion
ISO
Beryllium results in increased expression of TNF mRNA TNF promoter polymorphism results in increased susceptibility to Beryllium Beryllium results in increased secretion of TNF protein
CTD
PMID:8629860 PMID:12449171 PMID:15127972
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Acsl4
acyl-CoA synthetase long-chain family member 4
multiple interactions increases expression
ISO
[sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in increased expression of ACSL4 mRNA]; Deferoxamine inhibits the reaction [beryllium sulfate results in increased expression of ACSL4 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in increased expression of ACSL4 mRNA]
CTD
PMID:36843388
NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
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Acta2
actin alpha 2, smooth muscle
increases expression
ISO
beryllium sulfate results in increased expression of ACTA2 mRNA
CTD
PMID:16314022
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Amot
angiomotin
decreases expression
ISO
beryllium sulfate results in decreased expression of AMOT mRNA
CTD
PMID:35679967
NCBI chr X:108,982,399...109,041,265
Ensembl chr X:108,984,022...109,041,272
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Anxa5
annexin A5
increases expression
ISO
beryllium sulfate results in increased expression of ANXA5 mRNA
CTD
PMID:16314022
NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
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Arhgap26
Rho GTPase activating protein 26
increases expression decreases expression
ISO
beryllium sulfate results in increased expression of ARHGAP26 mRNA beryllium sulfate results in decreased expression of ARHGAP26 mRNA
CTD
PMID:35679967
NCBI chr18:30,835,806...31,237,945
Ensembl chr18:30,838,671...31,235,194
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Ccl3
C-C motif chemokine ligand 3
multiple interactions increases secretion
ISO
beryllium sulfate promotes the reaction [RUNX1 protein binds to CCL3 promoter] beryllium sulfate results in increased secretion of CCL3 mRNA
CTD
PMID:16314022
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl4
C-C motif chemokine ligand 4
increases secretion
ISO
beryllium sulfate results in increased secretion of CCL4 mRNA
CTD
PMID:16314022
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
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Ccl5
C-C motif chemokine ligand 5
increases expression
ISO
beryllium sulfate results in increased expression of CCL5 mRNA
CTD
PMID:16314022
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Ccnt1
cyclin T1
increases expression
ISO
beryllium sulfate results in increased expression of CCNT1 mRNA
CTD
PMID:35679967
NCBI chr 7:129,687,146...129,718,080
Ensembl chr 7:129,691,209...129,717,871
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Cd44
CD44 molecule
increases expression
ISO
beryllium sulfate results in increased expression of CD44 mRNA
CTD
PMID:16314022
NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
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Cd86
CD86 molecule
increases expression
ISO
beryllium sulfate results in increased expression of CD86 protein
CTD
PMID:19665512
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions increases expression
ISO
beryllium sulfate promotes the reaction [TP53 protein binds to CDKN1A promoter] beryllium sulfate results in increased expression of CDKN1A mRNA; beryllium sulfate results in increased expression of CDKN1A protein
CTD
PMID:17395767
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
increases expression
ISO
beryllium sulfate results in increased expression of CDKN2A mRNA; beryllium sulfate results in increased expression of CDKN2A protein
CTD
PMID:17395767
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Creb1
cAMP responsive element binding protein 1
multiple interactions
ISO
[beryllium sulfate co-treated with IFNG protein] results in increased expression of CREB1 protein
CTD
PMID:10755711
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Cryaa
crystallin, alpha A
decreases expression
ISO
beryllium sulfate results in decreased expression of CRYAA mRNA
CTD
PMID:35679967
NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349
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Ctsl
cathepsin L
increases expression
ISO
beryllium sulfate results in increased expression of CTSL mRNA
CTD
PMID:16314022
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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Cul9
cullin 9
increases expression decreases expression
ISO
beryllium sulfate results in increased expression of CUL9 mRNA beryllium sulfate results in decreased expression of CUL9 mRNA
CTD
PMID:35679967
NCBI chr 9:14,435,948...14,479,552
Ensembl chr 9:14,436,111...14,479,548
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Cxcl1
C-X-C motif chemokine ligand 1
increases secretion
ISO
beryllium sulfate results in increased secretion of CXCL1 mRNA
CTD
PMID:16314022
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl3
C-X-C motif chemokine ligand 3
increases secretion
ISO
beryllium sulfate results in increased secretion of CXCL1 mRNA
CTD
PMID:16314022
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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Ddhd2
DDHD domain containing 2
increases expression
ISO
beryllium sulfate results in increased expression of DDHD2 mRNA
CTD
PMID:35679967
NCBI chr16:66,319,469...66,349,025
Ensembl chr16:66,319,466...66,349,023
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Egr2
early growth response 2
increases expression
ISO
beryllium sulfate results in increased expression of EGR2 mRNA
CTD
PMID:16314022
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression multiple interactions
ISO
beryllium sulfate results in increased expression of FOS mRNA 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Dactinomycin inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]; Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of FOS mRNA]
CTD
PMID:11568973
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Fth1
ferritin heavy chain 1
multiple interactions decreases expression
ISO
[sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in decreased expression of FTH1 mRNA]; [sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in decreased expression of FTH1 protein]; Deferoxamine inhibits the reaction [beryllium sulfate results in decreased expression of FTH1 mRNA]; Deferoxamine inhibits the reaction [beryllium sulfate results in decreased expression of FTH1 protein]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of FTH1 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of FTH1 protein] beryllium sulfate results in decreased expression of FTH1 mRNA; beryllium sulfate results in decreased expression of FTH1 protein
CTD
PMID:36843388
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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Gpx4
glutathione peroxidase 4
multiple interactions decreases expression
ISO
[sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in decreased expression of GPX4 mRNA]; Deferoxamine inhibits the reaction [beryllium sulfate results in decreased expression of GPX4 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of GPX4 mRNA]
CTD
PMID:36843388
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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Hnrnpa1
heterogeneous nuclear ribonucleoprotein A1
increases expression
ISO
beryllium sulfate results in increased expression of HNRNPA1 mRNA
CTD
PMID:16314022
NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
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Icam1
intercellular adhesion molecule 1
multiple interactions increases secretion increases expression
ISO
3,3',4,5'-tetrahydroxystilbene inhibits the reaction [beryllium sulfate results in increased expression of ICAM1 mRNA]; 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [beryllium sulfate results in increased secretion of ICAM1 protein]; Dimethyl Sulfoxide inhibits the reaction [beryllium sulfate results in increased secretion of ICAM1 protein] beryllium sulfate results in increased expression of ICAM1 mRNA; beryllium sulfate results in increased expression of ICAM1 protein
CTD
PMID:18539414
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Ifng
interferon gamma
increases expression multiple interactions
ISO
beryllium sulfate results in increased expression of IFNG protein [beryllium sulfate co-treated with IFNG protein] results in increased expression of CREB1 protein; [beryllium sulfate co-treated with IFNG protein] results in increased expression of JUN protein; [beryllium sulfate co-treated with IFNG protein] results in increased expression of JUNB protein; [beryllium sulfate co-treated with IFNG protein] results in increased expression of NFKB1 protein; beryllium sulfate promotes the reaction [IFNG protein results in increased expression of TNF protein]
CTD
PMID:10755710 PMID:10755711 PMID:20974702 PMID:33197057
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il10
interleukin 10
increases expression
ISO
beryllium sulfate results in increased expression of IL10 protein
CTD
PMID:33197057
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il18
interleukin 18
increases expression
ISO
beryllium sulfate results in increased expression of IL18 mRNA; beryllium sulfate results in increased expression of IL18 protein
CTD
PMID:16100009
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il2
interleukin 2
increases expression
ISO
beryllium sulfate results in increased expression of IL2 mRNA
CTD
PMID:9328138
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
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Il5
interleukin 5
increases expression
ISO
beryllium sulfate results in increased expression of IL5 mRNA
CTD
PMID:9328138
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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Il6
interleukin 6
increases expression
ISO
beryllium sulfate results in increased expression of IL6 mRNA
CTD
PMID:9328138
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itgb3
integrin subunit beta 3
increases expression
ISO
beryllium sulfate results in increased expression of ITGB3 mRNA
CTD
PMID:16314022
NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]; [beryllium sulfate co-treated with IFNG protein] results in increased expression of JUN protein; Dactinomycin inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]; Ro 31-8220 inhibits the reaction [beryllium sulfate results in increased expression of JUN mRNA]
CTD
PMID:10755711 PMID:11568973
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
[beryllium sulfate co-treated with IFNG protein] results in increased expression of JUNB protein
CTD
PMID:10755711
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Krt4
keratin 4
decreases expression
ISO
beryllium sulfate results in decreased expression of KRT4 mRNA
CTD
PMID:35679967
NCBI chr 7:133,046,067...133,052,027
Ensembl chr 7:133,046,515...133,052,019
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Mfsd14b
major facilitator superfamily domain containing 14B
decreases expression
ISO
beryllium sulfate results in decreased expression of MFSD14B mRNA
CTD
PMID:35679967
NCBI chr17:77,895...130,837
Ensembl chr17:77,840...130,839
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Mir1306
microRNA 1306
increases expression
ISO
beryllium sulfate results in increased expression of MIR1306 mRNA
CTD
PMID:33197057
NCBI chr11:82,709,651...82,709,723
Ensembl chr11:82,709,637...82,709,719
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Mir150
microRNA 150
increases expression
ISO
beryllium sulfate results in increased expression of MIR150 mRNA
CTD
PMID:33197057
NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108
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Mir193b
microRNA 193b
increases expression
ISO
beryllium sulfate results in increased expression of MIR193B mRNA
CTD
PMID:33197057
NCBI chr10:1,317,742...1,317,824
Ensembl chr10:1,317,742...1,317,824
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Mir23b
microRNA 23b
decreases expression
ISO
beryllium sulfate results in decreased expression of MIR23B mRNA
CTD
PMID:33197057
NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763
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Mir324
microRNA 324
increases expression
ISO
beryllium sulfate results in increased expression of MIR324 mRNA
CTD
PMID:33197057
NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766
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Mir363
microRNA 363
increases expression
ISO
beryllium sulfate results in increased expression of MIR363 mRNA
CTD
PMID:33197057
NCBI chr X:132,421,791...132,421,877
Ensembl chr X:132,421,791...132,421,877
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Mir484
microRNA 484
decreases expression
ISO
beryllium sulfate results in decreased expression of MIR484 mRNA
CTD
PMID:33197057
NCBI chr10:887,684...887,760
Ensembl chr10:887,684...887,760
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Mir504
microRNA 504
increases expression
ISO
beryllium sulfate results in increased expression of MIR504 mRNA
CTD
PMID:33197057
NCBI chr X:137,318,540...137,318,616
Ensembl chr X:137,318,540...137,318,616
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Mir877
microRNA 877
increases expression
ISO
beryllium sulfate results in increased expression of MIR877 mRNA
CTD
PMID:33197057
NCBI chr20:2,811,476...2,811,560
Ensembl chr20:2,811,476...2,811,560
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Myc
MYC proto-oncogene, bHLH transcription factor
increases expression
EXP
beryllium sulfate results in increased expression of MYC protein
CTD
PMID:2009323
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Ncoa4
nuclear receptor coactivator 4
multiple interactions increases expression
ISO
[sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in increased expression of NCOA4 mRNA]; [sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in increased expression of NCOA4 protein]; Deferoxamine inhibits the reaction [beryllium sulfate results in increased expression of NCOA4 mRNA]; Deferoxamine inhibits the reaction [beryllium sulfate results in increased expression of NCOA4 protein]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of FTH1 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of FTH1 protein]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of GPX4 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of SLC7A11 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in increased expression of ACSL4 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in increased expression of NCOA4 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in increased expression of NCOA4 protein]; NCOA4 protein affects the reaction [beryllium sulfate results in increased expression of PTGS2 mRNA] beryllium sulfate results in increased expression of NCOA4 mRNA; beryllium sulfate results in increased expression of NCOA4 protein
CTD
PMID:36843388
NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
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Nedd8
NEDD8 ubiquitin like modifier
increases expression
ISO
beryllium sulfate results in increased expression of NEDD8 mRNA
CTD
PMID:16314022
NCBI chr15:29,153,556...29,165,575
Ensembl chr15:29,153,556...29,166,160
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
[beryllium sulfate co-treated with IFNG protein] results in increased expression of NFKB1 protein
CTD
PMID:10755711
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nos2
nitric oxide synthase 2
increases expression
ISO
beryllium sulfate results in increased expression of NOS2 protein
CTD
PMID:33197057
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nova1
NOVA alternative splicing regulator 1
increases expression
ISO
beryllium sulfate results in increased expression of NOVA1 mRNA
CTD
PMID:16314022
NCBI chr 6:63,780,105...63,905,567
Ensembl chr 6:63,783,489...63,906,289
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Pdpk1
3-phosphoinositide dependent protein kinase-1
decreases expression
ISO
beryllium sulfate results in decreased expression of PDPK1 mRNA
CTD
PMID:35679967
NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
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Phf19
PHD finger protein 19
decreases expression
ISO
beryllium sulfate results in decreased expression of PHF19 mRNA
CTD
PMID:35679967
NCBI chr 3:18,175,281...18,197,289
Ensembl chr 3:18,175,282...18,196,405
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression multiple interactions
ISO
beryllium sulfate results in increased expression of PTGS2 mRNA; beryllium sulfate results in increased expression of PTGS2 protein [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in increased expression of PTGS2 mRNA]; Deferoxamine inhibits the reaction [beryllium sulfate results in increased expression of PTGS2 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in increased expression of PTGS2 mRNA]
CTD
PMID:33197057 PMID:36843388
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rhoa
ras homolog family member A
increases expression
ISO
beryllium sulfate results in increased expression of RHOA mRNA
CTD
PMID:16314022
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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Rpl22
ribosomal protein L22
increases expression
ISO
beryllium sulfate results in increased expression of RPL22 mRNA
CTD
PMID:16314022
NCBI chr 5:162,835,241...162,843,394
Ensembl chr 5:162,833,740...162,843,368 Ensembl chr 7:162,833,740...162,843,368 Ensembl chr 4:162,833,740...162,843,368
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Rpl30
ribosomal protein L30
increases expression
ISO
beryllium sulfate results in increased expression of RPL30 mRNA
CTD
PMID:16314022
NCBI chr 7:65,648,266...65,651,401
Ensembl chr 7:65,645,991...65,651,363 Ensembl chr10:65,645,991...65,651,363 Ensembl chr10:65,645,991...65,651,363
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Rpl37a
ribosomal protein L37A
increases expression
ISO
beryllium sulfate results in increased expression of RPL37A mRNA
CTD
PMID:16314022
NCBI chr 9:74,298,843...74,300,926
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Rps7
ribosomal protein S7
increases expression
ISO
beryllium sulfate results in increased expression of RPS7 mRNA
CTD
PMID:16314022
NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145
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RT1-CE16
RT1 class I, locus CE16
increases expression
ISO
beryllium sulfate results in increased expression of HLA-A mRNA
CTD
PMID:16314022
NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
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RT1-Db1
RT1 class II, locus Db1
increases response to substance increases expression
ISO
HLA-DRB1 protein mutant form results in increased susceptibility to beryllium sulfate beryllium sulfate results in increased expression of HLA-DRB1 mRNA
CTD
PMID:16272364 PMID:16314022
NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
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RT1-Hb-ps1
RT1 class II, locus Hb, pseudogene 1
affects binding
ISO
beryllium sulfate binds to HLA-DPB1 protein
CTD
PMID:11423174
NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,774,650...4,780,618
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Runx1
RUNX family transcription factor 1
multiple interactions
ISO
beryllium sulfate promotes the reaction [RUNX1 protein binds to CCL3 promoter]
CTD
PMID:16314022
NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
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Serpinb2
serpin family B member 2
increases expression
ISO
beryllium sulfate results in increased expression of SERPINB2 mRNA
CTD
PMID:16314022
NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
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Sftpd
surfactant protein D
increases expression
ISO
beryllium sulfate results in increased expression of SFTPD mRNA
CTD
PMID:16314022
NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927
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Slc7a11
solute carrier family 7 member 11
multiple interactions decreases expression
ISO
[sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [beryllium sulfate results in decreased expression of SLC7A11 mRNA]; Deferoxamine inhibits the reaction [beryllium sulfate results in decreased expression of SLC7A11 mRNA]; NCOA4 protein affects the reaction [beryllium sulfate results in decreased expression of SLC7A11 mRNA]
CTD
PMID:36843388
NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Tat
tyrosine aminotransferase
multiple interactions
EXP
beryllium sulfate inhibits the reaction [Hydrocortisone results in increased expression of TAT protein]
CTD
PMID:6120038
NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
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Thsd7a
thrombospondin type 1 domain containing 7A
decreases expression increases expression
ISO
beryllium sulfate results in decreased expression of THSD7A mRNA beryllium sulfate results in increased expression of THSD7A mRNA
CTD
PMID:35679967
NCBI chr 4:40,461,124...40,899,345
Ensembl chr 4:40,460,814...40,899,583
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Tmsb4x
thymosin beta 4, X-linked
increases expression
ISO
beryllium sulfate results in increased expression of TMSB4X mRNA
CTD
PMID:16314022
NCBI chr X:27,144,666...27,146,667
Ensembl chr X:27,128,610...27,146,667
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Tnf
tumor necrosis factor
increases expression multiple interactions
ISO
beryllium sulfate results in increased expression of TNF mRNA; beryllium sulfate results in increased expression of TNF protein beryllium sulfate promotes the reaction [IFNG protein results in increased expression of TNF protein]
CTD
PMID:10755710 PMID:10755711 PMID:33197057
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
multiple interactions increases expression
ISO
beryllium sulfate promotes the reaction [TP53 protein binds to CDKN1A promoter] beryllium sulfate results in increased expression of TP53 protein
CTD
PMID:17395767 PMID:20974702
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Wnt4
Wnt family member 4
increases expression
ISO
beryllium sulfate results in increased expression of WNT4 mRNA
CTD
PMID:16314022
NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859
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Zfp77
zinc finger protein 77
increases expression
ISO
beryllium sulfate results in increased expression of ZNF77 mRNA
CTD
PMID:16314022
NCBI chr 7:7,269,879...7,316,286
Ensembl chr 7:7,269,927...7,286,051
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Cdkn2a
cyclin-dependent kinase inhibitor 2A
multiple interactions
EXP
[Beryllium results in increased methylation of CDKN2A promoter] which results in decreased expression of CDKN2A mRNA
CTD
PMID:11872642
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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Esr1
estrogen receptor 1
increases methylation
EXP
Beryllium results in increased methylation of ESR1 gene
CTD
PMID:11872642
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Hras
HRas proto-oncogene, GTPase
increases mutagenesis
EXP
Beryllium results in increased mutagenesis of HRAS gene
CTD
PMID:7545909
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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Il1b
interleukin 1 beta
increases expression affects expression
ISO
Beryllium results in increased expression of IL1B mRNA Beryllium affects the expression of IL1B mRNA
CTD
PMID:8473757 PMID:8629860
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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RT1-Hb-ps1
RT1 class II, locus Hb, pseudogene 1
increases response to substance affects binding
ISO
HLA-DPB1 gene polymorphism results in increased susceptibility to Beryllium; HLA-DPB1 gene SNP results in increased susceptibility to Beryllium; HLA-DPB1 protein mutant form results in increased susceptibility to Beryllium HLA-DPB1 protein mutant form binds to Beryllium
CTD
PMID:11551429 PMID:15273960 PMID:17956852
NCBI chr20:4,775,598...4,779,590
Ensembl chr20:4,774,650...4,780,618
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Tnf
tumor necrosis factor
increases response to substance increases secretion increases expression
ISO
TNF promoter polymorphism results in increased susceptibility to Beryllium Beryllium results in increased secretion of TNF protein Beryllium results in increased expression of TNF mRNA
CTD
PMID:8629860 PMID:12449171 PMID:15127972
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Pdxp
pyridoxal phosphatase
decreases activity
ISO
beryllium trifluoride results in decreased activity of PDXP protein
CTD
PMID:24338473
NCBI chr 7:110,472,515...110,477,963
Ensembl chr 7:110,472,515...110,477,963
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Pgp
phosphoglycolate phosphatase
decreases activity
ISO
beryllium trifluoride results in decreased activity of PGP protein
CTD
PMID:24338473
NCBI chr10:13,495,232...13,497,858
Ensembl chr10:13,494,291...13,497,858
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