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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isobutyl group
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Accession:CHEBI:30356 term browser browse the term
Synonyms:exact_synonym: 2-methylpropan-1-ido;   2-methylpropyl;   isobutyl
 related_synonym: (CH3)2CH-CH2-;   -CH2-CH(CH3)2;   Formula=C4H9;   SMILES=CC(C)C*;   iBu;   leucine side-chain


show annotations for term's descendants           Sort by:
aloxistatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAPN1 calpain 1 multiple interactions EXP aloxistatin inhibits the reaction [CAPN1 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006 		JBrowse link
G CAPN7 calpain 7 multiple interactions EXP aloxistatin inhibits the reaction [CAPN7 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr 3:15,206,246...15,252,916
Ensembl chr 3:15,206,152...15,252,916 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP
ISO		 [aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]
[Swainsonine co-treated with aloxistatin] results in increased cleavage of CASP3 protein		 CTD PMID:26853465 PMID:33186601 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 multiple interactions EXP aloxistatin inhibits the reaction [syringic acid analog results in increased secretion of CASP9 protein] CTD PMID:34523043 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CTSB cathepsin B multiple interactions EXP [aloxistatin co-treated with pepstatin] results in decreased expression of CTSB protein; aloxistatin inhibits the reaction [CTSB protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 PMID:32186374 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533 		JBrowse link
G CTSD cathepsin D multiple interactions EXP [aloxistatin co-treated with pepstatin] results in decreased expression of CTSD protein CTD PMID:32186374 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573 		JBrowse link
G CTSL cathepsin L multiple interactions EXP aloxistatin inhibits the reaction [CTSL protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,724,051...87,731,469 		JBrowse link
G DDX3X DEAD-box helicase 3 X-linked multiple interactions EXP aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein] CTD PMID:30821613 NCBI chr  X:41,333,308...41,364,472
Ensembl chr  X:41,333,348...41,364,472 		JBrowse link
G EIF4A1 eukaryotic translation initiation factor 4A1 multiple interactions EXP aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein] CTD PMID:30821613 NCBI chr17:7,572,825...7,579,006
Ensembl chr17:7,572,824...7,579,006 		JBrowse link
G EIF4H eukaryotic translation initiation factor 4H multiple interactions EXP aloxistatin inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein] CTD PMID:30821613 NCBI chr 7:74,174,356...74,197,096
Ensembl chr 7:74,174,231...74,197,122 		JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP aloxistatin inhibits the reaction [syringic acid analog results in increased secretion of GAPDH protein] CTD PMID:34523043 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374 		JBrowse link
G LAMP2 lysosomal associated membrane protein 2 multiple interactions EXP [aloxistatin co-treated with pepstatin] results in increased expression of LAMP2 protein CTD PMID:32186374 NCBI chr  X:120,426,148...120,469,349
Ensembl chr  X:120,426,148...120,469,365 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions
increases lipidation		 ISO
EXP		 [aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] results in increased expression of MAP1LC3B protein
aloxistatin results in increased lipidation of MAP1LC3B protein
[aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] promotes the reaction [ABTL0812 results in increased expression of and results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] promotes the reaction [Brefeldin A results in increased expression of and results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] promotes the reaction [N-((1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl)octanamide results in increased expression of and results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] results in decreased degradation of MAP1LC3B protein modified form; aloxistatin promotes the reaction [indatraline results in increased lipidation of MAP1LC3B protein]		 CTD PMID:26483381 PMID:27635674 PMID:32397857 PMID:33124469 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G SMN2 survival of motor neuron 2, centromeric multiple interactions EXP aloxistatin inhibits the reaction [CAPN1 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form]; aloxistatin inhibits the reaction [CAPN7 protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form]; aloxistatin inhibits the reaction [CTSB protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form]; aloxistatin inhibits the reaction [CTSL protein results in increased degradation of and results in decreased expression of SMN2 protein alternative form] CTD PMID:30910806 NCBI chr 5:70,049,523...70,090,528
Ensembl chr 5:70,049,638...70,078,522
Ensembl chr 5:70,049,638...70,078,522 		JBrowse link
G SQSTM1 sequestosome 1 multiple interactions
increases expression		 EXP
ISO		 [aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; aloxistatin promotes the reaction [indatraline results in increased expression of SQSTM1 protein]; aloxistatin promotes the reaction [Sertraline results in increased expression of SQSTM1 protein]
aloxistatin results in increased expression of SQSTM1 protein
[aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [Dronabinol co-treated with aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [HU 211 co-treated with aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein		 CTD PMID:26483381 PMID:32186374 PMID:32773031 PMID:33124469 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
L-leucine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATG5 autophagy related 5 multiple interactions ISO Leucine inhibits the reaction [alpinetin promotes the reaction [Dextran Sulfate results in increased expression of ATG5 mRNA]] CTD PMID:31676321 NCBI chr 6:106,184,476...106,325,760
Ensembl chr 6:106,045,423...106,325,791 		JBrowse link
G ATG7 autophagy related 7 multiple interactions ISO Leucine inhibits the reaction [alpinetin promotes the reaction [Dextran Sulfate results in increased expression of ATG7 mRNA]] CTD PMID:31676321 NCBI chr 3:11,272,397...11,576,353
Ensembl chr 3:11,272,309...11,557,665 		JBrowse link
G BECN1 beclin 1 multiple interactions ISO Leucine inhibits the reaction [[Dextran Sulfate co-treated with alpinetin] results in increased expression of BECN1 protein] CTD PMID:31676321 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G CASP3 caspase 3 multiple interactions ISO Leucine inhibits the reaction [alpinetin inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]] CTD PMID:31676321 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G EGF epidermal growth factor multiple interactions ISO [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine] CTD PMID:22689575 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions ISO Leucine inhibits the reaction [[Dextran Sulfate co-treated with alpinetin] results in increased expression of and results in increased lipidation of MAP1LC3B protein] CTD PMID:31676321 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO Leucine inhibits the reaction [alpinetin inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]] CTD PMID:31676321 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G SLC3A2 solute carrier family 3 member 2 affects import EXP SLC3A2 protein affects the import of Leucine CTD PMID:28786956 NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,004...62,888,880 		JBrowse link
G SLC7A8 solute carrier family 7 member 8 affects import EXP SLC7A8 protein affects the import of Leucine CTD PMID:28786956 NCBI chr14:23,125,295...23,183,660
Ensembl chr14:23,125,295...23,183,674 		JBrowse link
G SQSTM1 sequestosome 1 multiple interactions ISO Leucine inhibits the reaction [[Dextran Sulfate co-treated with alpinetin] results in decreased expression of SQSTM1 protein] CTD PMID:31676321 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
Leu-enkephalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPP3 dipeptidyl peptidase 3 multiple interactions
increases cleavage		 EXP spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine] CTD PMID:10873616 NCBI chr11:66,480,434...66,509,657
Ensembl chr11:66,480,013...66,509,657 		JBrowse link
G OPRD1 opioid receptor delta 1 increases activity EXP Enkephalin, Leucine results in increased activity of OPRD1 protein CTD PMID:26476280 NCBI chr 1:28,812,170...28,871,267
Ensembl chr 1:28,812,170...28,871,267 		JBrowse link
G OPRM1 opioid receptor mu 1 increases activity EXP Enkephalin, Leucine results in increased activity of OPRM1 protein CTD PMID:26476280 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867 		JBrowse link
methyl L-leucinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNF tumor necrosis factor multiple interactions ISO leucine methyl ester inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:21748807 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
N-formyl-L-methionyl-L-leucyl-L-phenylalanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase multiple interactions EXP ADA protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides] CTD PMID:10947063 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation
increases activity
multiple interactions		 EXP
ISO		 N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein
N-Formylmethionine Leucyl-Phenylalanine results in increased activity of AKT1 protein
2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [AKT1 protein binds to NCF1 protein]]; 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of AKT1 protein]; N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [AKT1 protein binds to NCF1 protein]
cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]		 CTD PMID:15925284 PMID:16621998 PMID:19445920 PMID:34144024 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G ALOX5 arachidonate 5-lipoxygenase multiple interactions EXP [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]; ALOX5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of ALOX5 protein; SB 203580 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of ALOX5 protein] CTD PMID:9495842 PMID:10779545 PMID:11116075 NCBI chr10:45,374,216...45,446,117
Ensembl chr10:45,374,176...45,446,119 		JBrowse link
G ARF1 ARF GTPase 1 affects localization EXP N-Formylmethionine Leucyl-Phenylalanine affects the localization of ARF1 protein CTD PMID:10931844 NCBI chr 1:228,082,708...228,099,212
Ensembl chr 1:228,082,708...228,099,212 		JBrowse link
G ARF6 ARF GTPase 6 multiple interactions
affects localization		 EXP 1-Butanol inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 1-Butanol inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]; ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]
N-Formylmethionine Leucyl-Phenylalanine affects the localization of ARF6 protein		 CTD PMID:10931844 NCBI chr14:49,893,082...49,897,054
Ensembl chr14:49,893,079...49,897,054 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases activity EXP N-Formylmethionine Leucyl-Phenylalanine results in increased activity of BAX protein CTD PMID:20130848 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity		 EXP Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP3 protein] CTD PMID:20130848 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 multiple interactions
increases activity		 EXP Melatonin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CASP9 protein] CTD PMID:20130848 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CD38 CD38 molecule increases cleavage
multiple interactions		 EXP N-Formylmethionine Leucyl-Phenylalanine results in increased cleavage of CD38 protein
SB 203580 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased cleavage of CD38 protein]		 CTD PMID:15494208 NCBI chr 4:15,778,328...15,853,232
Ensembl chr 4:15,778,275...15,853,232 		JBrowse link
G CD63 CD63 molecule multiple interactions
increases expression		 EXP Mustard Gas promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]; Quercetin affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]; SB 203580 inhibits the reaction [Mustard Gas promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CD63 protein]] CTD PMID:19887118 PMID:22036725 NCBI chr12:55,723,535...55,730,041
Ensembl chr12:55,725,323...55,729,707 		JBrowse link
G CTSG cathepsin G multiple interactions
increases secretion		 EXP cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of CTSG protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of CTSG protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of CTSG protein] CTD PMID:25980585 PMID:34144024 NCBI chr14:24,573,518...24,576,250
Ensembl chr14:24,573,518...24,576,250 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression
increases secretion
multiple interactions		 EXP N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CXCL8 mRNA; N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CXCL8 protein
N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of CXCL8 protein
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CXCL8 protein]; nimesulide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CXCL8 protein]; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of CXCL8 mRNA]; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of CXCL8 protein]		 CTD PMID:11566077 PMID:12946449 PMID:17459229 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYBA cytochrome b-245 alpha chain multiple interactions ISO 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of NCF1 protein] promotes the reaction [NCF1 protein binds to CYBA protein]]; [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of NCF1 protein] promotes the reaction [NCF1 protein binds to CYBA protein] CTD PMID:19445920 NCBI chr16:88,643,289...88,651,053
Ensembl chr16:88,643,275...88,651,083 		JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions
increases activity		 ISO diphenyleneiodonium inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CYBB protein]; Genistein inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of CYBB protein] CTD PMID:29183754 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,018...37,813,461 		JBrowse link
G ELANE elastase, neutrophil expressed multiple interactions
increases secretion		 EXP 2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of ELANE protein]; [Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein; pirinixic acid analog inhibits the reaction [[Cytochalasin B co-treated with N-Formylmethionine Leucyl-Phenylalanine] results in increased secretion of ELANE protein] CTD PMID:19686721 PMID:21457779 NCBI chr19:852,303...856,243
Ensembl chr19:851,014...856,247 		JBrowse link
G ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 multiple interactions
increases expression		 EXP Quercetin affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ENPP3 protein] CTD PMID:19887118 NCBI chr 6:131,637,302...131,747,410
Ensembl chr 6:131,628,442...131,747,418 		JBrowse link
G FGR FGR proto-oncogene, Src family tyrosine kinase multiple interactions
increases phosphorylation		 EXP 1-Butanol inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with dihydrocytochalasin B] results in increased activity of FGR protein]
N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of FGR protein		 CTD PMID:11078731 PMID:25980585 NCBI chr 1:27,612,064...27,635,185
Ensembl chr 1:27,612,064...27,635,185 		JBrowse link
G FPR1 formyl peptide receptor 1 multiple interactions EXP N-Formylmethionine Leucyl-Phenylalanine binds to and results in increased activity of FPR1 protein CTD PMID:17520823 NCBI chr19:51,745,172...51,751,878
Ensembl chr19:51,745,172...51,804,115 		JBrowse link
G GUSB glucuronidase beta increases secretion
multiple interactions		 ISO
EXP		 N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of GUSB protein
epigallocatechin gallate inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of GUSB protein]		 CTD PMID:9545557 PMID:11944907 NCBI chr 7:65,960,684...65,982,213
Ensembl chr 7:65,960,684...65,982,215 		JBrowse link
G HCK HCK proto-oncogene, Src family tyrosine kinase increases phosphorylation EXP N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of HCK protein CTD PMID:25980585 NCBI chr20:32,052,242...32,101,856
Ensembl chr20:32,052,197...32,101,856 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases expression		 EXP N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of IL1B protein]; nimesulide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of IL1B protein] CTD PMID:12946449 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL3 interleukin 3 increases response to substance ISO IL3 protein results in increased susceptibility to N-Formylmethionine Leucyl-Phenylalanine CTD PMID:11145705 NCBI chr 5:132,060,655...132,063,204
Ensembl chr 5:132,060,655...132,063,204 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression		 EXP N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of IL6 protein]; nimesulide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of IL6 protein] CTD PMID:12946449 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G ITGA2B integrin subunit alpha 2b multiple interactions EXP ITGA2B protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein] CTD PMID:11116075 NCBI chr17:44,372,181...44,389,649
Ensembl chr17:44,372,180...44,389,649 		JBrowse link
G ITGAM integrin subunit alpha M multiple interactions
increases expression 		EXP 2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; dimemorfan inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; Foropafant inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; KT 5720 inhibits the reaction [2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Rolipram inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; plaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; Rolipram inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]; Staurosporine inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]
fMLP increases expression of ITGAM protein on neutrophils and monocytes
[N-formyl-methionyl-leucyl-phenylalanine cotreated with midazolam] decreases expression of ITGAM protein on neutrophils		 CTD
RGD		 PMID:10215738 PMID:11116075 PMID:15774851 PMID:18500357 PMID:21457779 More... RGD:329901666, RGD:329853762 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G ITGB2 integrin subunit beta 2 increases expression
multiple interactions		 ISO
EXP		 N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; crenatoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; plaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]		 CTD PMID:10215738 PMID:16393473 PMID:21664406 NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989 		JBrowse link
G ITGB3 integrin subunit beta 3 increases expression ISO N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB3 protein CTD PMID:21664406 NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,827...47,313,743 		JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase multiple interactions
increases phosphorylation		 EXP AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of LYN protein] CTD PMID:25980585 NCBI chr 8:55,879,835...56,014,169
Ensembl chr 8:55,879,835...56,014,169 		JBrowse link
G LYZ lysozyme increases secretion ISO N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of LYZ protein CTD PMID:9545557 NCBI chr12:69,348,381...69,354,234
Ensembl chr12:69,348,381...69,354,234 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP
ISO		 cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; Grape Seed Proanthocyanidins inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Pentoxifylline inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Qingdai compound inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; Resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]
N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein; resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]
RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11145705 PMID:11427526 PMID:15494208 PMID:16212921 PMID:16621998 More... NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions
increases phosphorylation		 EXP
ISO		 N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK14 protein; Omeprazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK14 protein] CTD PMID:16621998 PMID:17406807 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,752...36,122,511 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP
ISO		 cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; Grape Seed Proanthocyanidins inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Pentoxifylline inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Qingdai compound inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; Resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]
N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein; resveratrol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]
RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11145705 PMID:11427526 PMID:15494208 PMID:16212921 PMID:16621998 More... NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP
ISO		 N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK8 protein; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK8 protein]
MAPK8 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Reactive Oxygen Species]; N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK8 protein		 CTD PMID:17377739 PMID:17560994 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MMP8 matrix metallopeptidase 8 increases expression ISO N-Formylmethionine Leucyl-Phenylalanine results in increased expression of MMP8 protein CTD PMID:32367270 NCBI chr11:102,711,796...102,724,954
Ensembl chr11:102,711,796...102,727,050 		JBrowse link
G MPO myeloperoxidase multiple interactions
increases activity
increases secretion
increases expression		 ISO
EXP		 carvedilol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of MPO protein]
N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein
N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein
Carvedilol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein]; diphenyleneiodonium inhibits the reaction [manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]]; manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]; Sodium Azide inhibits the reaction [manganese chloride promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of MPO protein]]; Wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein]		 CTD PMID:16601795 PMID:17159805 PMID:18987595 PMID:22906169 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions
increases phosphorylation
affects localization		 EXP
ISO		 AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF1 protein]; bisindolylmaleimide I inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF1 protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF1 protein]
N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of NCF1 protein
2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of NCF1 protein] promotes the reaction [NCF1 protein binds to CYBA protein]]; 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF1 protein]; 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [AKT1 protein binds to NCF1 protein]]; 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [NCF1 protein binds to PAK1 protein]]; 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of NCF1 protein]; [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of NCF1 protein] promotes the reaction [NCF1 protein binds to CYBA protein]; N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [AKT1 protein binds to NCF1 protein]; N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [NCF1 protein binds to PAK1 protein]		 CTD PMID:19445920 PMID:25980585 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315 		JBrowse link
G NCF2 neutrophil cytosolic factor 2 affects localization
multiple interactions		 ISO N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF2 protein
2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF2 protein]		 CTD PMID:19445920 NCBI chr 1:183,555,562...183,601,849
Ensembl chr 1:183,554,461...183,590,905 		JBrowse link
G NCF4 neutrophil cytosolic factor 4 affects localization
multiple interactions		 ISO N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF4 protein
2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of NCF4 protein]		 CTD PMID:19445920 NCBI chr22:36,861,006...36,878,015
Ensembl chr22:36,860,988...36,878,017 		JBrowse link
G PAK1 p21 (RAC1) activated kinase 1 multiple interactions ISO 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PAK1 protein]; 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [NCF1 protein binds to PAK1 protein]]; N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased activity of PAK1 protein; N-Formylmethionine Leucyl-Phenylalanine promotes the reaction [NCF1 protein binds to PAK1 protein] CTD PMID:19445920 NCBI chr11:77,322,017...77,530,009
Ensembl chr11:77,322,017...77,474,635 		JBrowse link
G PAK2 p21 (RAC1) activated kinase 2 increases phosphorylation
multiple interactions		 ISO N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of PAK2 protein
2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of PAK2 protein]		 CTD PMID:19445920 NCBI chr 3:196,739,857...196,832,647
Ensembl chr 3:196,739,857...196,832,647 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 increases expression ISO N-Formylmethionine Leucyl-Phenylalanine results in increased expression of PECAM1 protein CTD PMID:21664406 NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776 		JBrowse link
G PLA2G4A phospholipase A2 group IVA multiple interactions EXP PLA2G4A protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased metabolism of Leukotriene B4] CTD PMID:11741884 NCBI chr 1:186,828,949...186,988,981
Ensembl chr 1:186,828,949...186,988,981 		JBrowse link
G PLA2G5 phospholipase A2 group V increases activity
multiple interactions
increases secretion		 EXP N-Formylmethionine Leucyl-Phenylalanine results in increased activity of PLA2G5 protein
PLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Arachidonic Acid]; PLA2G5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Leukotriene C4]
N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of PLA2G5 protein		 CTD PMID:9495842 PMID:11741884 NCBI chr 1:20,028,408...20,091,911
Ensembl chr 1:20,028,179...20,091,911 		JBrowse link
G PLCG2 phospholipase C gamma 2 multiple interactions
increases phosphorylation		 EXP AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of PLCG2 protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of PLCG2 protein] CTD PMID:25980585 NCBI chr16:81,739,041...81,962,685
Ensembl chr16:81,738,248...81,962,685 		JBrowse link
G PLD1 phospholipase D1 multiple interactions EXP
ISO		 PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
PLD1 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Reactive Oxygen Species]		 CTD PMID:11427526 PMID:17560994 NCBI chr 3:171,600,404...171,810,483
Ensembl chr 3:171,600,404...171,810,950 		JBrowse link
G PRKCA protein kinase C alpha multiple interactions ISO 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCA protein]; N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCA protein CTD PMID:19445920 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743 		JBrowse link
G PRKCB protein kinase C beta multiple interactions ISO 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCB protein]; N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCB protein CTD PMID:19445920 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611 		JBrowse link
G PRKCD protein kinase C delta multiple interactions ISO 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCD protein]; N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCD protein CTD PMID:19445920 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions ISO 2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCZ protein]; N-Formylmethionine Leucyl-Phenylalanine affects the localization of and results in increased phosphorylation of PRKCZ protein CTD PMID:19445920 NCBI chr 1:2,048,504...2,185,395
Ensembl chr 1:2,050,411...2,185,395 		JBrowse link
G PTAFR platelet activating factor receptor multiple interactions EXP PTAFR protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein] CTD PMID:11116075 NCBI chr 1:28,147,166...28,193,856
Ensembl chr 1:28,147,166...28,193,936 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP N-Formylmethionine Leucyl-Phenylalanine results in increased expression of PTGS2 mRNA; N-Formylmethionine Leucyl-Phenylalanine results in increased expression of PTGS2 protein CTD PMID:12946449 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RAC1 Rac family small GTPase 1 increases activity
multiple interactions		 ISO N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein
2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein]
6-amino-N-(3-(4-(4-morpholinyl)pyrido(3',2'-4,5)furo(3,2-d)pyrimidin-2-yl)phenyl)-3-pyridinecarboxamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein]; apilimod inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein]; RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein]		 CTD PMID:16621998 PMID:19445920 PMID:28779020 NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967 		JBrowse link
G RAC2 Rac family small GTPase 2 increases activity
decreases activity
multiple interactions		 ISO N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein
N-Formylmethionine Leucyl-Phenylalanine results in decreased activity of RAC2 protein
2-benzyl-3-(4-hydroxymethylphenyl)indazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in decreased activity of RAC2 protein]
6-amino-N-(3-(4-(4-morpholinyl)pyrido(3',2'-4,5)furo(3,2-d)pyrimidin-2-yl)phenyl)-3-pyridinecarboxamide inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]; apilimod inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]; RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK1 protein]; RAC2 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK3 protein]; RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]		 CTD PMID:11145705 PMID:16621998 PMID:19445920 PMID:28779020 NCBI chr22:37,225,270...37,244,269
Ensembl chr22:37,225,270...37,259,594 		JBrowse link
G RHOG ras homolog family member G multiple interactions
affects response to substance		 ISO RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC1 protein]; RHOG gene mutant form inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased activity of RAC2 protein]
RHOG protein affects the susceptibility to N-Formylmethionine Leucyl-Phenylalanine		 CTD PMID:16621998 NCBI chr11:3,826,978...3,840,959
Ensembl chr11:3,826,978...3,840,959 		JBrowse link
G SELL selectin L increases expression ISO N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELL protein CTD PMID:21664406 NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702 		JBrowse link
G SELP selectin P multiple interactions
increases expression		 EXP ALOX5 protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; Foropafant inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; ITGA2B protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; MK-886 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; PTAFR protein promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; SR 121566 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein]; zileuton inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of SELP protein] CTD PMID:11116075 NCBI chr 1:169,588,849...169,630,124
Ensembl chr 1:169,588,849...169,630,193 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase increases phosphorylation
multiple interactions		 EXP N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein
AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein]; cyclosporin H inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein]; epsilon-viniferin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of SRC protein]		 CTD PMID:25980585 PMID:34144024 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G TEC tec protein tyrosine kinase multiple interactions
affects localization		 EXP AG 1879 inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of TEC protein]; honokiol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine affects the localization of TEC protein] CTD PMID:25980585 NCBI chr 4:48,135,783...48,269,838
Ensembl chr 4:48,135,783...48,269,838 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression		 EXP [N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides; Cyclosporine inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]; Tacrolimus inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]
N-Formylmethionine Leucyl-Phenylalanine results in increased expression of TNF protein		 CTD PMID:11121130 PMID:12946449 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFAIP6 TNF alpha induced protein 6 decreases response to substance EXP TNFAIP6 protein modified form results in decreased susceptibility to N-Formylmethionine Leucyl-Phenylalanine CTD PMID:12401803 NCBI chr 2:151,357,592...151,381,340
Ensembl chr 2:151,357,592...151,380,046 		JBrowse link
G VAV1 vav guanine nucleotide exchange factor 1 increases phosphorylation EXP N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of VAV1 protein CTD PMID:25980585 NCBI chr19:6,772,708...6,857,361
Ensembl chr19:6,772,708...6,857,366 		JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions
increases expression
increases secretion		 EXP Masoprocol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA mRNA]; Masoprocol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of VEGFA protein]; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA mRNA]; nordy inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of VEGFA protein]
N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA mRNA; N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA protein		 CTD PMID:17377739 PMID:17459229 PMID:17520823 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
orlistat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD12 abhydrolase domain containing 12, lysophospholipase decreases activity EXP orlistat results in decreased activity of ABHD12 protein CTD PMID:18657971 NCBI chr20:25,294,743...25,390,835
Ensembl chr20:25,294,742...25,390,835 		JBrowse link
G ABHD16A abhydrolase domain containing 16A, phospholipase decreases activity EXP orlistat results in decreased activity of ABHD16A protein CTD PMID:18657971 NCBI chr 6:31,686,955...31,703,324
Ensembl chr 6:31,686,955...31,703,356 		JBrowse link
G ACACA acetyl-CoA carboxylase alpha multiple interactions
decreases expression		 EXP Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]
Orlistat results in decreased expression of ACACA mRNA		 CTD PMID:32347045 PMID:33476690 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G ACHE acetylcholinesterase (Yt blood group) decreases activity EXP Orlistat results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974 		JBrowse link
G ACOT8 acyl-CoA thioesterase 8 decreases expression EXP Orlistat results in decreased expression of ACOT8 protein CTD PMID:30667213 NCBI chr20:45,841,721...45,857,392
Ensembl chr20:45,841,721...45,857,405 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions ISO
EXP		 orlistat inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]
Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]		 CTD PMID:25087745 PMID:33476690 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Malondialdehyde]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Triglycerides]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP [1,1,1,2,2-pentafluoro-7-phenylheptan-3-one co-treated with Orlistat] inhibits the reaction [APP protein modified form results in increased secretion of Arachidonic Acid] CTD PMID:28721267 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G ATF4 activating transcription factor 4 increases expression EXP orlistat results in increased expression of ATF4 mRNA CTD PMID:17283163 NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,686 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of BAX mRNA] CTD PMID:32450208 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in decreased expression of BCL2 mRNA] CTD PMID:32450208 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G CASP3 caspase 3 increases cleavage
multiple interactions
increases activity		 EXP
ISO		 orlistat results in increased cleavage of CASP3 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP3 mRNA]
orlistat results in increased activity of CASP3 protein		 CTD PMID:17283163 PMID:20805790 PMID:21723078 PMID:32450208 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 multiple interactions EXP
ISO		 orlistat analog results in increased cleavage of and results in increased activity of CASP8 protein; orlistat results in increased cleavage of and results in increased activity of CASP8 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP8 mRNA]		 CTD PMID:18796435 PMID:20577697 PMID:32450208 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 increases activity
multiple interactions		 ISO orlistat results in increased activity of CASP9 protein
Orlistat inhibits the reaction [Dietary Fats results in increased expression of CASP9 mRNA]		 CTD PMID:20805790 PMID:32450208 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase multiple interactions
decreases expression		 ISO
EXP		 Orlistat inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; Orlistat inhibits the reaction [Dietary Fats results in decreased expression of CAT mRNA]; Orlistat inhibits the reaction [Dietary Fats results in decreased expression of CAT protein]
Orlistat results in decreased expression of CAT protein		 CTD PMID:25087745 PMID:30667213 PMID:32450208 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCK cholecystokinin decreases secretion
multiple interactions		 EXP orlistat results in decreased secretion of CCK protein
[[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein; orlistat inhibits the reaction [Fats results in increased secretion of CCK protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of CCK protein]		 CTD PMID:11408251 PMID:18303078 PMID:18647814 NCBI chr 3:42,257,826...42,266,185
Ensembl chr 3:42,257,825...42,266,185 		JBrowse link
G CCNA2 cyclin A2 decreases expression EXP Orlistat results in decreased expression of CCNA2 protein CTD PMID:30667213 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCND1 cyclin D1 increases expression
multiple interactions		 EXP Orlistat results in increased expression of CCND1 protein
Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]		 CTD PMID:30667213 PMID:32045588 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCNE1 cyclin E1 increases expression EXP Orlistat results in increased expression of CCNE1 protein CTD PMID:30667213 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CD34 CD34 molecule multiple interactions EXP Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein] CTD PMID:32045588 NCBI chr 1:207,880,972...207,911,125
Ensembl chr 1:207,880,972...207,911,402 		JBrowse link
G CDK1 cyclin dependent kinase 1 decreases expression EXP Orlistat results in decreased expression of CDK1 protein CTD PMID:30667213 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression EXP Orlistat results in decreased expression of CDK2 protein CTD PMID:30667213 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP Orlistat results in decreased expression of CDK4 protein CTD PMID:30667213 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP Orlistat results in increased expression of CDKN1A protein CTD PMID:30667213 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP orlistat results in increased expression of CDKN1B protein CTD PMID:15138278 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CEBPA CCAAT enhancer binding protein alpha multiple interactions EXP Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein] CTD PMID:33476690 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534 		JBrowse link
G CEL carboxyl ester lipase decreases activity EXP orlistat results in decreased activity of CEL protein CTD PMID:11592731 PMID:12381337 NCBI chr 9:133,061,981...133,071,861
Ensembl chr 9:133,061,981...133,071,861 		JBrowse link
G CLPS colipase multiple interactions EXP orlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil] CTD PMID:15158758 NCBI chr 6:35,794,982...35,797,323
Ensembl chr 6:35,794,982...35,797,344 		JBrowse link
G CPB2 carboxypeptidase B2 decreases expression EXP orlistat results in decreased expression of CPB2 protein CTD PMID:16959692 NCBI chr13:46,053,186...46,105,033
Ensembl chr13:46,053,186...46,105,033 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A decreases expression EXP Orlistat results in decreased expression of CPT1A protein CTD PMID:30667213 NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410 		JBrowse link
G CPT2 carnitine palmitoyltransferase 2 decreases expression EXP Orlistat results in decreased expression of CPT2 protein CTD PMID:30667213 NCBI chr 1:53,196,824...53,214,197
Ensembl chr 1:53,196,792...53,214,197 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP orlistat inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA] CTD PMID:21088047 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases expression EXP orlistat results in increased expression of CYP3A4 mRNA; orlistat results in increased expression of CYP3A4 protein CTD PMID:20599501 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G DAGLA diacylglycerol lipase alpha decreases activity EXP orlistat results in decreased activity of DAGLA protein CTD PMID:16466961 NCBI chr11:61,680,391...61,747,001
Ensembl chr11:61,680,391...61,747,001 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP orlistat results in increased expression of DDIT3 mRNA CTD PMID:17283163 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G DDIT4 DNA damage inducible transcript 4 increases expression EXP orlistat results in increased expression of DDIT4 mRNA CTD PMID:18796435 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036 		JBrowse link
G EIF2A eukaryotic translation initiation factor 2A increases phosphorylation
multiple interactions		 ISO
EXP		 orlistat results in increased phosphorylation of EIF2A protein
Cycloheximide inhibits the reaction [orlistat results in increased phosphorylation of EIF2A protein]
orlistat promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]
orlistat analog results in increased phosphorylation of EIF2A protein; orlistat results in increased phosphorylation of EIF2A protein		 CTD PMID:17283163 PMID:20577697 NCBI chr 3:150,546,787...150,586,016
Ensembl chr 3:150,546,678...150,586,016 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases response to substance		 ISO orlistat promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]
EIF2AK3 gene mutant form results in increased susceptibility to orlistat		 CTD PMID:17283163 NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518 		JBrowse link
G EIF4E eukaryotic translation initiation factor 4E increases phosphorylation EXP orlistat results in increased phosphorylation of EIF4E protein CTD PMID:18796435 NCBI chr 4:98,879,276...98,929,133
Ensembl chr 4:98,879,276...98,929,133 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 decreases expression
affects localization
affects response to substance		 EXP orlistat results in decreased expression of ERBB2 mRNA; orlistat results in decreased expression of ERBB2 protein
orlistat affects the localization of ERBB2 protein
ERBB2 protein affects the susceptibility to orlistat		 CTD PMID:15870086 NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP orlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819 		JBrowse link
G ETV4 ETS variant transcription factor 4 increases expression EXP orlistat results in increased expression of ETV4 protein CTD PMID:15870086 NCBI chr17:43,527,846...43,546,340
Ensembl chr17:43,527,844...43,579,620 		JBrowse link
G FABP1 fatty acid binding protein 1 decreases expression EXP Orlistat results in decreased expression of FABP1 protein CTD PMID:30667213 NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062 		JBrowse link
G FAS Fas cell surface death receptor decreases expression EXP Orlistat results in decreased expression of FAS mRNA CTD PMID:32347045 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASN fatty acid synthase multiple interactions
decreases expression
affects response to substance
affects binding
decreases activity		 ISO
EXP		 [orlistat results in decreased activity of FASN protein] which affects the abundance of Fatty Acids, Nonesterified; orlistat inhibits the reaction [FASN protein results in increased chemical synthesis of Palmitic Acid]
Orlistat results in decreased expression of FASN protein
FASN protein affects the susceptibility to orlistat
orlistat analog binds to FASN protein
[Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Fatty Acids; [Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphatidylcholines; [Orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphorylcholine; [Orlistat results in decreased activity of FASN protein] which results in decreased chemical synthesis of Fatty Acids; [Orlistat results in decreased activity of FASN protein] which results in decreased expression of SKP2 protein; Orlistat binds to and results in decreased activity of FASN protein; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Doxorubicin]; Orlistat inhibits the reaction [FASN protein results in decreased susceptibility to Mitoxantrone]
orlistat analog results in decreased activity of FASN protein; orlistat results in decreased activity of FASN protein		 CTD PMID:15026345 PMID:15138278 PMID:15870086 PMID:17012255 PMID:17618296 More... NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G GCG glucagon decreases secretion
multiple interactions
decreases expression		 EXP orlistat results in decreased secretion of GCG protein
orlistat inhibits the reaction [Dietary Fats results in increased secretion of GCG protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of GCG protein]
orlistat results in decreased expression of GCG protein		 CTD PMID:12915676 PMID:18647814 PMID:19837920 NCBI chr 2:162,142,882...162,152,247
Ensembl chr 2:162,142,882...162,152,404 		JBrowse link
G GHRL ghrelin and obestatin prepropeptide multiple interactions EXP orlistat inhibits the reaction [Olive Oil results in decreased expression of GHRL protein]; orlistat inhibits the reaction [Triglycerides results in decreased secretion of GHRL protein] CTD PMID:15998659 PMID:17138722 NCBI chr 3:10,285,666...10,292,947
Ensembl chr 3:10,285,666...10,292,947 		JBrowse link
G GIP gastric inhibitory polypeptide decreases expression EXP orlistat results in decreased expression of GIP protein CTD PMID:12915676 NCBI chr17:48,958,554...48,968,596
Ensembl chr17:48,958,554...48,968,596 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO orlistat inhibits the reaction [[Corn Oil co-treated with (5'-(4-amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido(4,5-b)(1,4)oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl)acetic acid] results in increased activity of GPT protein] CTD PMID:29479035 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in decreased expression of GPX1 mRNA] CTD PMID:32450208 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GPX8 glutathione peroxidase 8 (putative) increases expression EXP orlistat results in increased expression of GPX8 mRNA CTD PMID:18796435 NCBI chr 5:55,160,171...55,167,297
Ensembl chr 5:55,160,167...55,167,297 		JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in decreased expression of GSR protein] CTD PMID:32450208 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G HBA1 hemoglobin subunit alpha 1 decreases expression EXP orlistat results in decreased expression of HBA1 protein modified form CTD PMID:19207292 PMID:19461584 NCBI chr16:176,680...177,522
Ensembl chr16:176,680...177,522 		JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO orlistat inhibits the reaction [Dietary Fats results in increased expression of HMGCR protein] CTD PMID:25087745 NCBI chr 5:75,336,529...75,362,116
Ensembl chr 5:75,336,329...75,364,001 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP orlistat results in increased expression of HSPA5 mRNA CTD PMID:17283163 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G IL10 interleukin 10 increases expression ISO Orlistat results in increased expression of IL10 mRNA CTD PMID:32450208 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of IL1B mRNA] CTD PMID:32450208 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP
ISO		 Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
Orlistat inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]		 CTD PMID:21088047 PMID:32045588 PMID:32735172 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G INS insulin increases expression
multiple interactions
affects expression
decreases expression		 EXP orlistat results in increased expression of INS protein
[Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]; Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein]
orlistat affects the expression of INS protein
orlistat results in decreased expression of INS protein		 CTD PMID:10095983 PMID:11274935 PMID:12915676 PMID:33476690 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of INS1 protein] CTD PMID:25087745 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G KDELR3 KDEL endoplasmic reticulum protein retention receptor 3 increases expression EXP orlistat results in increased expression of KDELR3 mRNA CTD PMID:18796435 NCBI chr22:38,468,096...38,483,447
Ensembl chr22:38,468,078...38,483,447 		JBrowse link
G KDR kinase insert domain receptor decreases expression EXP orlistat results in decreased expression of KDR protein CTD PMID:17012255 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G KRT81 keratin 81 increases expression EXP orlistat results in increased expression of KRT81 mRNA CTD PMID:18796435 NCBI chr12:52,285,913...52,291,534
Ensembl chr12:52,285,913...52,291,534 		JBrowse link
G LCAT lecithin-cholesterol acyltransferase multiple interactions ISO orlistat inhibits the reaction [Dietary Fats results in decreased expression of LCAT protein] CTD PMID:25087745 NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131 		JBrowse link
G LEP leptin multiple interactions ISO orlistat inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:21332399 PMID:25087745 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G LIPF lipase F, gastric type decreases activity EXP orlistat results in decreased activity of LIPF protein CTD PMID:11408251 PMID:12381337 NCBI chr10:88,664,442...88,678,814
Ensembl chr10:88,664,441...88,678,814 		JBrowse link
G LPL lipoprotein lipase multiple interactions
decreases activity		 ISO
EXP		 [orlistat results in decreased activity of LPL protein] which affects the uptake of Triglycerides
orlistat inhibits the reaction [Dietary Fats results in decreased expression of LPL protein]
orlistat inhibits the reaction [[LPL protein results in increased hydrolysis of Triglycerides] which results in increased uptake of Triglycerides]; orlistat inhibits the reaction [LPL protein results in decreased activity of TNF protein]; orlistat inhibits the reaction [very low density lipoprotein triglyceride results in increased activity of LPL protein]		 CTD PMID:12388125 PMID:12573449 PMID:15910848 PMID:15994321 PMID:18698144 More... NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein] CTD PMID:32045588 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein] CTD PMID:32045588 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase multiple interactions EXP Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Malondialdehyde]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased abundance of Triglycerides]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CCND1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of CD34 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of FASN protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of IL6 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK1 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of MAPK3 protein]; Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr 7:116,672,196...116,798,377
Ensembl chr 7:116,672,196...116,798,377 		JBrowse link
G NAPEPLD N-acyl phosphatidylethanolamine phospholipase D decreases activity ISO orlistat results in decreased activity of NAPEPLD protein CTD PMID:16466961 NCBI chr 7:103,099,776...103,150,001
Ensembl chr 7:103,099,776...103,149,560 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO
EXP		 Orlistat inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 mRNA]
[Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA		 CTD PMID:32450208 PMID:33476690 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of NOS2 mRNA]; Orlistat inhibits the reaction [Dietary Fats results in increased expression of NOS2 protein] CTD PMID:32450208 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NPY neuropeptide Y increases expression EXP orlistat results in increased expression of NPY protein CTD PMID:15962606 NCBI chr 7:24,284,190...24,291,862
Ensembl chr 7:24,284,188...24,291,862 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP orlistat results in increased activity of NR1I2 protein CTD PMID:20599501 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions EXP Orlistat binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:31312845 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244 		JBrowse link
G NTS neurotensin multiple interactions EXP orlistat inhibits the reaction [Fats results in increased secretion of NTS protein]; orlistat inhibits the reaction [Olive Oil results in increased secretion of NTS protein] CTD PMID:18303078 NCBI chr12:85,874,295...85,882,992
Ensembl chr12:85,874,295...85,882,992 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 EXP orlistat results in increased cleavage of PARP1 protein
[orlistat co-treated with Thapsigargin] results in increased cleavage of PARP1 protein		 CTD PMID:15870086 PMID:17283163 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions EXP Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PCNA protein] CTD PMID:32045588 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PLA2G7 phospholipase A2 group VII multiple interactions
decreases activity		 EXP [orlistat co-treated with Ezetimibe] results in decreased activity of PLA2G7 protein; [orlistat co-treated with Fenofibrate] results in decreased activity of PLA2G7 protein
orlistat results in decreased activity of PLA2G7 protein		 CTD PMID:16911813 PMID:18513463 PMID:18657971 NCBI chr 6:46,704,201...46,735,721
Ensembl chr 6:46,704,201...46,735,693 		JBrowse link
G PNLIP pancreatic lipase decreases secretion
multiple interactions
affects folding
decreases activity		 EXP
ISO		 orlistat results in decreased secretion of PNLIP protein
[[orlistat results in decreased abundance of Fatty Acids, Nonesterified] which results in decreased secretion of CCK protein] which results in decreased secretion of PNLIP protein; orlistat inhibits the reaction [[PNLIP protein co-treated with CLPS protein] results in increased hydrolysis of Olive Oil]
orlistat affects the folding of PNLIP protein
orlistat results in decreased activity of PNLIP protein
orlistat inhibits the reaction [Taurocholic Acid results in increased activity of PNLIP protein]		 CTD PMID:11408251 PMID:11668201 PMID:12381337 PMID:15158758 PMID:19346257 NCBI chr10:116,545,931...116,567,855
Ensembl chr10:116,545,931...116,567,855 		JBrowse link
G PNLIPRP2 pancreatic lipase related protein 2 (gene/pseudogene) decreases activity EXP
ISO		 orlistat results in decreased activity of PNLIPRP2 protein
Orlistat results in decreased activity of PNLIPRP2 protein		 CTD PMID:9822688 PMID:17401110 NCBI chr10:116,620,953...116,645,143
Ensembl chr10:116,620,953...116,645,143 		JBrowse link
G PON1 paraoxonase 1 increases activity EXP orlistat results in increased activity of PON1 protein CTD PMID:11820148 PMID:17134960 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta multiple interactions EXP Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA] CTD PMID:33476690 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression EXP Orlistat results in increased expression of PPARG mRNA CTD PMID:32347045 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PPT1 palmitoyl-protein thioesterase 1 decreases expression EXP Orlistat results in decreased expression of PPT1 protein CTD PMID:30667213 NCBI chr 1:40,071,461...40,097,252
Ensembl chr 1:40,072,710...40,097,260 		JBrowse link
G PPY pancreatic polypeptide multiple interactions EXP orlistat inhibits the reaction [Triglycerides results in increased secretion of PPY protein] CTD PMID:15998659 NCBI chr17:43,940,804...43,944,215
Ensembl chr17:43,940,804...43,942,476 		JBrowse link
G PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein]
orlistat inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; orlistat inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of PRKAA1 protein]		 CTD PMID:18390901 PMID:19167487 NCBI chr 5:40,759,389...40,798,374
Ensembl chr 5:40,759,389...40,798,374 		JBrowse link
G PTEN phosphatase and tensin homolog multiple interactions
increases expression		 EXP Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in decreased expression of PTEN protein]
Orlistat results in increased expression of PTEN protein		 CTD PMID:32045588 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of PTGS2 protein] CTD PMID:32045588 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PYY peptide YY decreases secretion
multiple interactions		 EXP orlistat results in decreased secretion of PYY protein
Orlistat inhibits the reaction [Olive Oil results in increased expression of PYY protein]; Orlistat inhibits the reaction [Triglycerides results in increased secretion of PYY protein]		 CTD PMID:15998659 PMID:17138722 PMID:18647814 NCBI chr17:43,952,733...44,004,445
Ensembl chr17:43,952,733...44,004,469 		JBrowse link
G RB1 RB transcriptional corepressor 1 decreases phosphorylation EXP orlistat results in decreased phosphorylation of RB1 protein CTD PMID:15138278 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of RELA mRNA] CTD PMID:32450208 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RPS6 ribosomal protein S6 multiple interactions EXP Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased phosphorylation of RPS6 protein] CTD PMID:32045588 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236 		JBrowse link
G SEC24D SEC24 homolog D, COPII coat complex component increases expression EXP orlistat results in increased expression of SEC24D mRNA CTD PMID:18796435 NCBI chr 4:118,722,823...118,836,126
Ensembl chr 4:118,722,823...118,838,683 		JBrowse link
G SKP2 S-phase kinase associated protein 2 decreases expression
multiple interactions		 EXP orlistat results in decreased expression of SKP2 protein
[orlistat results in decreased activity of FASN protein] which results in decreased expression of SKP2 protein		 CTD PMID:15138278 NCBI chr 5:36,152,111...36,193,530
Ensembl chr 5:36,151,989...36,196,849 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP orlistat inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 decreases expression
multiple interactions		 EXP Orlistat results in decreased expression of SREBF1 protein
Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of SREBF1 protein]		 CTD PMID:32045588 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G TF transferrin multiple interactions EXP [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of NFE2L2 mRNA; [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ACACA mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of ADIPOQ protein]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of FASN mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of PPARD mRNA]; Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA]; Orlistat promotes the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of CEBPA protein] CTD PMID:33476690 NCBI chr 3:133,661,998...133,796,641
Ensembl chr 3:133,746,040...133,796,641 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP [Orlistat co-treated with Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in decreased expression of TGFB1 mRNA CTD PMID:33476690 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of TLR4 protein] CTD PMID:32735172 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP
ISO		 Orlistat inhibits the reaction [[AKT1 gene mutant form co-treated with MET gene mutant form] results in increased expression of TNF protein]; Orlistat inhibits the reaction [LPL protein results in decreased activity of TNF protein]
Orlistat inhibits the reaction [Dietary Fats results in increased expression of TNF protein]
Orlistat inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]		 CTD PMID:15994321 PMID:32045588 PMID:32450208 PMID:32735172 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFSF10 TNF superfamily member 10 increases response to substance EXP orlistat results in increased susceptibility to TNFSF10 protein CTD PMID:18796435 PMID:21406729 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
G TP53 tumor protein p53 multiple interactions ISO Orlistat inhibits the reaction [Dietary Fats results in increased expression of TP53 mRNA] CTD PMID:32450208 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G UCP1 uncoupling protein 1 multiple interactions EXP Orlistat inhibits the reaction [[Rosiglitazone co-treated with TF protein co-treated with INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Hydrocortisone co-treated with Triiodothyronine] results in increased expression of UCP1 mRNA] CTD PMID:33476690 NCBI chr 4:140,559,431...140,568,961
Ensembl chr 4:140,559,431...140,568,961 		JBrowse link
G XBP1 X-box binding protein 1 multiple interactions EXP orlistat affects the reaction [ERN1 protein affects the splicing of XBP1 mRNA] CTD PMID:17283163 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26503
    role 26325
      application 25589
        refrigerant 20382
          isobutane 1444
            isobutyl group 179
              (+)-flavipucine 0
              (-)-flavipucine 0
              isoflavipucine 0
              leucine + 179
Path 2
Term Annotations click to browse term
  CHEBI ontology 26503
    subatomic particle 26479
      composite particle 26479
        hadron 26479
          baryon 26479
            nucleon 26479
              atomic nucleus 26479
                atom 26479
                  main group element atom 26216
                    main group molecular entity 26216
                      s-block molecular entity 25453
                        hydrogen molecular entity 24860
                          hydrides 23080
                            organic hydride 22044
                              organic fundamental parent 22044
                                hydrocarbon 21483
                                  alkane 15696
                                    alkyl group 4430
                                      isobutyl group 179
                                        (+)-flavipucine 0
                                        (-)-flavipucine 0
                                        isoflavipucine 0
                                        leucine + 179
paths to the root