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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isopropyl group
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Accession:CHEBI:30353 term browser browse the term
Synonyms:exact_synonym: isopropyl;   propan-2-yl
 related_synonym: (CH3)2CH-;   -CH(CH3)2;   1-methylethyl;   Formula=C3H7;   SMILES=CC(*)C;   iPr;   valine side-chain


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fluvalinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions ISO fluvalinate analog promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:25684042 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Cdk2 cyclin dependent kinase 2 affects binding ISO fluvalinate binds to CDK2 protein CTD PMID:32278787 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 affects binding ISO fluvalinate binds to ERBB2 protein CTD PMID:32278787 NCBI chr11:98,303,310...98,328,542
Ensembl chr11:98,303,296...98,328,542 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 affects binding ISO fluvalinate binds to FGFR2 protein CTD PMID:32278787 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079 		JBrowse link
G Mmp9 matrix metallopeptidase 9 affects binding ISO fluvalinate binds to MMP9 protein CTD PMID:32278787 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 affects binding ISO fluvalinate binds to NQO1 protein CTD PMID:32278787 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO fluvalinate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO
EXP		 fluvalinate binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Ppard peroxisome proliferator activator receptor delta affects binding ISO fluvalinate binds to PPARD protein CTD PMID:32278787 NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448 		JBrowse link
G Rora RAR-related orphan receptor alpha affects binding ISO fluvalinate binds to RORA protein CTD PMID:32278787 NCBI chr 9:68,560,627...69,295,528
Ensembl chr 9:68,561,068...69,295,528 		JBrowse link
G Rorc RAR-related orphan receptor gamma affects binding ISO fluvalinate binds to RORC protein CTD PMID:32278787 NCBI chr 3:94,280,106...94,305,583
Ensembl chr 3:94,280,101...94,305,583 		JBrowse link
ledipasvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) affects binding ISO ledipasvir binds to ABCG2 protein CTD PMID:33954893 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Klrc1 killer cell lectin-like receptor subfamily C, member 1 decreases expression ISO ledipasvir co-treated with sofosbuvir decreases expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 6:129,642,978...129,659,815
Ensembl chr 6:129,642,978...129,655,936 		JBrowse link
G Ncr1 natural cytotoxicity triggering receptor 1 affects expression ISO ledipasvir co-treated sofosbuvir with affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 7:4,340,714...4,348,183
Ensembl chr 7:4,340,723...4,348,163 		JBrowse link
ritonavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity
multiple interactions		 ISO Ritonavir results in decreased activity of ABCB11 protein
Ritonavir inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:20829430 PMID:22646477 PMID:23956101 PMID:24014644 PMID:28437613 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions ISO hyperforin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] CTD PMID:15266218 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb4 ATP-binding cassette, sub-family B member 4 decreases expression
decreases activity		 ISO Ritonavir results in decreased expression of ABCB4
Ritonavir results in decreased activity of ABCB4 protein		 CTD PMID:26626330 PMID:28437613 NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231 		JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 affects expression ISO Ritonavir affects the expression of ACSS2 mRNA CTD PMID:17719200 NCBI chr 2:155,359,963...155,404,663
Ensembl chr 2:155,359,868...155,427,644 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
multiple interactions		 EXP
ISO		 Ritonavir results in decreased expression of ADIPOQ mRNA; Ritonavir results in decreased expression of ADIPOQ protein
rosiglitazone inhibits the reaction [Ritonavir results in decreased secretion of ADIPOQ protein]
diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of ADIPOQ protein]		 CTD PMID:15865214 PMID:17668557 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation EXP Ritonavir results in increased phosphorylation of AKT1 protein CTD PMID:36198369 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Alb albumin affects binding ISO Ritonavir binds to ALB protein CTD PMID:15814459 PMID:16336266 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Ritonavir results in increased expression of BAK1 protein CTD PMID:19386116 NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO Ritonavir results in decreased expression of BCL2 protein CTD PMID:19386116 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 decreases expression ISO Ritonavir results in decreased expression of BCL2L1 mRNA CTD PMID:16174765 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Ritonavir results in decreased expression of BIRC5 mRNA; Ritonavir results in decreased expression of BIRC5 protein CTD PMID:16174765 PMID:21270666 NCBI chr11:117,740,063...117,746,569
Ensembl chr11:117,740,077...117,746,569 		JBrowse link
G Casp1 caspase 1 decreases expression ISO Ritonavir results in decreased expression of CASP1 protein CTD PMID:10551732 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 decreases activity ISO Ritonavir results in decreased activity of CASP3 protein CTD PMID:10551732 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
increases secretion
decreases expression		 ISO diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of CCL2 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of CCL2 protein]
Ritonavir results in decreased expression of CCL2		 CTD PMID:17668557 PMID:20884875 PMID:26626330 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression ISO Ritonavir results in decreased expression of CCL20 CTD PMID:26626330 NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 decreases expression
increases expression		 ISO Ritonavir results in decreased expression of CCL3
Ritonavir results in increased expression of CCL3 protein		 CTD PMID:17668557 PMID:26626330 NCBI chr11:83,538,669...83,540,204
Ensembl chr11:83,538,670...83,540,181 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Ritonavir results in decreased expression of CCL4 CTD PMID:26626330 NCBI chr11:83,553,410...83,555,509
Ensembl chr11:83,553,410...83,555,509 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Ritonavir results in decreased expression of CCNA2 mRNA CTD PMID:19386116 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Ritonavir results in decreased expression of CCNB1 mRNA CTD PMID:19386116 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Ritonavir results in decreased expression of CCND1 protein CTD PMID:16551874 PMID:21270666 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO Ritonavir results in decreased expression of CCND2 mRNA CTD PMID:16174765 PMID:19386116 NCBI chr 6:127,102,125...127,131,913
Ensembl chr 6:127,102,125...127,129,156 		JBrowse link
G Ccne2 cyclin E2 decreases expression ISO Ritonavir results in decreased expression of CCNE2 mRNA CTD PMID:19386116 NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Ritonavir results in decreased expression of CDK2 mRNA; Ritonavir results in decreased expression of CDK2 protein CTD PMID:16551874 PMID:19386116 NCBI chr10:128,533,807...128,540,920
Ensembl chr10:128,533,808...128,540,900 		JBrowse link
G Cdk3 cyclin dependent kinase 3 increases expression ISO Ritonavir results in increased expression of CDK3 mRNA CTD PMID:19386116 NCBI chr11:116,106,828...116,111,113
Ensembl chr11:116,106,829...116,111,113 		JBrowse link
G Cdk4 cyclin dependent kinase 4 decreases expression ISO Ritonavir results in decreased expression of CDK4 mRNA; Ritonavir results in decreased expression of CDK4 protein CTD PMID:16551874 PMID:19386116 NCBI chr10:126,899,404...126,903,157
Ensembl chr10:126,899,403...126,903,789 		JBrowse link
G Cdk5 cyclin dependent kinase 5 decreases expression ISO Ritonavir results in decreased expression of CDK5 mRNA CTD PMID:19386116 NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528 		JBrowse link
G Cdk6 cyclin dependent kinase 6 decreases expression ISO Ritonavir results in decreased expression of CDK6 mRNA; Ritonavir results in decreased expression of CDK6 protein CTD PMID:16551874 PMID:19386116 NCBI chr 5:3,391,004...3,581,008
Ensembl chr 5:3,391,485...3,581,008 		JBrowse link
G Cdkn1a cyclin dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased expression of CDKN1A protein]
Ritonavir results in increased expression of CDKN1A mRNA; Ritonavir results in increased expression of CDKN1A protein		 CTD PMID:19386116 PMID:20884875 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701 		JBrowse link
G Cdkn1b cyclin dependent kinase inhibitor 1B increases expression ISO Ritonavir results in increased expression of CDKN1B mRNA CTD PMID:19386116 NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476 		JBrowse link
G Cdkn2b cyclin dependent kinase inhibitor 2B increases expression ISO Ritonavir results in increased expression of CDKN2B mRNA CTD PMID:19386116 NCBI chr 4:89,224,526...89,229,269
Ensembl chr 4:89,224,536...89,229,276 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions EXP Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CEBPA protein] CTD PMID:11101056 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Ciita class II transactivator increases expression ISO Ritonavir results in increased expression of CIITA CTD PMID:26626330 NCBI chr16:10,297,877...10,348,928
Ensembl chr16:10,297,923...10,346,282 		JBrowse link
G Crot carnitine O-octanoyltransferase decreases expression ISO Ritonavir results in decreased expression of CROT mRNA CTD PMID:17719200 NCBI chr 5:9,016,033...9,047,926
Ensembl chr 5:9,016,033...9,047,324 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Ritonavir results in decreased expression of CXCL1 CTD PMID:26626330 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases expression ISO Ritonavir results in decreased expression of CXCL10 CTD PMID:26626330 NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Ritonavir results in decreased expression of CXCL12 CTD PMID:26626330 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 multiple interactions
decreases expression
increases secretion		 ISO Pravastatin inhibits the reaction [Ritonavir results in increased secretion of CXCL8 protein]
Ritonavir results in decreased expression of CXCL8		 CTD PMID:20884875 PMID:26626330 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Ritonavir results in decreased expression of CXCL2 CTD PMID:26626330 NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Ritonavir results in decreased expression of CXCL1 CTD PMID:26626330 NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459 		JBrowse link
G Cxcl5 C-X-C motif chemokine ligand 5 decreases expression ISO Ritonavir results in decreased expression of CXCL6 CTD PMID:26626330 NCBI chr 5:90,907,157...90,909,484
Ensembl chr 5:90,907,219...90,909,483 		JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 affects expression ISO Ritonavir affects the expression of CYB5R3 mRNA CTD PMID:17719200 NCBI chr15:83,037,696...83,060,641
Ensembl chr15:83,037,695...83,056,793 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity		 ISO Ritonavir results in increased expression of CYP1A1 mRNA
Ritonavir results in decreased activity of CYP1A1 protein		 CTD PMID:11918509 PMID:33814510 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression		 ISO Ritonavir results in increased expression of CYP1A2 mRNA
Ritonavir results in decreased expression of CYP1A2 mRNA		 CTD PMID:11918509 PMID:17719200 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Ritonavir results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr17:80,014,369...80,022,490
Ensembl chr17:80,008,966...80,022,490 		JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases activity
increases expression		 ISO Ritonavir results in increased activity of CYP2B6 protein
Ritonavir results in increased expression of CYP2B6 protein		 CTD PMID:14977870 PMID:26626330 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049 		JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 decreases activity ISO Ritonavir results in decreased activity of CYP2C8 protein CTD PMID:15601807 NCBI chr19:39,275,541...39,319,157
Ensembl chr19:39,257,849...39,319,157 		JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 increases expression ISO Ritonavir results in increased expression of CYP2C19 mRNA CTD PMID:11918509 NCBI chr19:39,379,109...39,451,519
Ensembl chr19:39,378,000...39,451,519 		JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases activity
increases expression		 ISO Ritonavir results in increased activity of CYP2C9 protein
Ritonavir results in increased expression of CYP2C9 mRNA		 CTD PMID:11918509 PMID:19202563 NCBI chr19:39,049,450...39,082,392
Ensembl chr19:39,049,459...39,082,388 		JBrowse link
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 affects metabolic processing ISO CYP2D6 protein affects the metabolism of Ritonavir CTD PMID:15286053 NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461 		JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 decreases activity ISO Ritonavir results in decreased activity of CYP3A5 protein CTD PMID:15523003 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 affects expression
decreases expression		 ISO Ritonavir affects the expression of CYP4B1 mRNA
Ritonavir results in decreased expression of CYP4B1 mRNA		 CTD PMID:17719200 NCBI chr 4:115,481,895...115,504,918
Ensembl chr 4:115,481,922...115,504,920 		JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression ISO Ritonavir results in increased expression of CYP51 mRNA CTD PMID:17719200 NCBI chr 5:4,130,674...4,154,697
Ensembl chr 5:4,131,145...4,154,746 		JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 decreases expression ISO Ritonavir results in decreased expression of CYP7A1 mRNA CTD PMID:17719200 PMID:26626330 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633 		JBrowse link
G Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 decreases expression ISO Ritonavir results in decreased expression of CYP8B1
Ritonavir results in decreased expression of CYP8B1 mRNA		 CTD PMID:17719200 PMID:26626330 NCBI chr 9:121,743,422...121,745,371
Ensembl chr 9:121,743,422...121,745,371 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase affects expression ISO Ritonavir affects the expression of DHCR7 mRNA CTD PMID:17719200 NCBI chr 7:143,376,827...143,402,147
Ensembl chr 7:143,376,882...143,402,147 		JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Ritonavir results in decreased expression of E2F1 mRNA; Ritonavir results in decreased expression of E2F1 protein CTD PMID:19386116 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G E2f2 E2F transcription factor 2 decreases expression ISO Ritonavir results in decreased expression of E2F2 mRNA CTD PMID:19386116 NCBI chr 4:135,899,585...135,923,368
Ensembl chr 4:135,899,705...135,923,368 		JBrowse link
G E2f3 E2F transcription factor 3 decreases expression ISO Ritonavir results in decreased expression of E2F3 mRNA CTD PMID:19386116 NCBI chr13:30,090,558...30,171,172
Ensembl chr13:30,090,558...30,170,046 		JBrowse link
G Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase affects expression ISO Ritonavir affects the expression of EHHADH mRNA CTD PMID:17719200 NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) decreases expression ISO Ritonavir results in decreased expression of ESR1 protein CTD PMID:16551874 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Fasl Fas ligand decreases expression ISO Ritonavir results in decreased expression of FASLG protein CTD PMID:10551732 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fasn fatty acid synthase affects expression ISO Ritonavir affects the expression of FASN mRNA CTD PMID:17719200 NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373 		JBrowse link
G Fgf15 fibroblast growth factor 15 increases expression ISO Ritonavir results in increased expression of FGF19 mRNA CTD PMID:26626330 NCBI chr 7:144,450,269...144,454,690
Ensembl chr 7:144,450,268...144,454,690 		JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO Ritonavir results in increased expression of FOS protein CTD PMID:15504750 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions
increases activity		 ISO Acetylcysteine inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; FTI 277 inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein] CTD PMID:20884875 NCBI chr 9:114,230,146...114,303,447
Ensembl chr 9:114,230,144...114,303,966 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble) multiple interactions EXP Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of GPD1 protein] CTD PMID:11101056 NCBI chr15:99,615,468...99,622,895
Ensembl chr15:99,615,396...99,622,886 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Bilirubin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Ritonavir results in increased expression of ICAM1 protein]; NFE2L2 protein mutant form inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Ritonavir promotes the reaction [Atazanavir Sulfate results in increased expression of HMOX1 mRNA]; Ritonavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [Lopinavir results in increased expression of HMOX1 mRNA]; Rotenone inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; tricarbonyldichlororuthenium (II) dimer promotes the reaction [Ritonavir results in increased expression of HMOX1 protein]
Ritonavir results in increased expression of HMOX1 mRNA; Ritonavir results in increased expression of HMOX1 protein		 CTD PMID:15504750 PMID:26968795 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 affects response to substance EXP HSP90AA1 protein affects the susceptibility to Ritonavir CTD PMID:16551874 NCBI chr12:110,657,470...110,662,829
Ensembl chr12:110,657,039...110,669,162 		JBrowse link
G Hsph1 heat shock 105kDa/110kDa protein 1 increases expression ISO Ritonavir results in increased expression of HSPH1 protein CTD PMID:26626330 NCBI chr 5:149,540,308...149,562,594
Ensembl chr 5:149,537,752...149,559,841 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions		 ISO Ritonavir results in increased expression of ICAM1 protein
HMOX1 protein inhibits the reaction [Ritonavir results in increased expression of ICAM1 protein]		 CTD PMID:26968795 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifng interferon gamma multiple interactions ISO Ritonavir inhibits the reaction [IFNG protein results in increased secretion of TNF protein] CTD PMID:10551732 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
increases secretion		 ISO
EXP		 diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of IL6 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of IL6 protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
rosiglitazone inhibits the reaction [Ritonavir results in increased expression of IL6 mRNA]
Ritonavir results in increased expression of IL6 mRNA; Ritonavir results in increased expression of IL6 protein		 CTD PMID:15388451 PMID:15865214 PMID:17668557 PMID:20884875 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Il7 interleukin 7 decreases expression ISO Ritonavir results in decreased expression of IL7 CTD PMID:26626330 NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820 		JBrowse link
G Ins1 insulin I multiple interactions EXP Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CEBPA protein]; Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG protein]; Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of GPD1 protein]; Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein] CTD PMID:11101056 NCBI chr19:52,252,735...52,253,453
Ensembl chr19:52,252,735...52,253,914 		JBrowse link
G Jun jun proto-oncogene increases expression ISO Ritonavir results in increased expression of JUN protein CTD PMID:15504750 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Lep leptin multiple interactions
decreases expression		 ISO diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein] CTD PMID:17668557 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Lif leukemia inhibitory factor decreases expression ISO Ritonavir results in decreased expression of LIF CTD PMID:26626330 NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514 		JBrowse link
G Lmna lamin A increases expression
increases farnesylation		 ISO Ritonavir results in increased expression of LMNA protein
Ritonavir results in increased farnesylation of LMNA protein alternative form		 CTD PMID:18230615 PMID:20884875 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263 		JBrowse link
G Lpl lipoprotein lipase affects expression EXP Ritonavir affects the expression of LPL mRNA CTD PMID:11741158 NCBI chr 8:69,333,207...69,359,584
Ensembl chr 8:69,333,143...69,360,100 		JBrowse link
G Myc myelocytomatosis oncogene decreases expression ISO Ritonavir results in decreased expression of MYC mRNA CTD PMID:16174765 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 increases expression
multiple interactions		 ISO Ritonavir results in increased expression of NFE2L2 protein
NFE2L2 protein mutant form inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]		 CTD PMID:26968795 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 decreases activity ISO Ritonavir results in decreased activity of NFKB1 protein CTD PMID:16174765 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases phosphorylation ISO Ritonavir results in decreased phosphorylation of NFKBIA protein CTD PMID:16174765 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nlrc5 NLR family, CARD domain containing 5 decreases expression ISO Ritonavir results in decreased expression of NLRC5 CTD PMID:26626330 NCBI chr 8:95,160,963...95,253,900
Ensembl chr 8:95,160,984...95,253,900 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell multiple interactions
decreases expression		 ISO Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA] CTD PMID:22037733 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Notch4 notch 4 decreases expression
multiple interactions		 ISO Ritonavir results in decreased expression of NOTCH4 protein
[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]		 CTD PMID:20722969 NCBI chr17:34,783,257...34,807,517
Ensembl chr17:34,783,242...34,807,477 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Ritonavir increases expression of NR1H3 mRNA in macrophages RGD PMID:18849545 RGD:401842387 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression ISO Ritonavir results in increased expression of NR1H4 mRNA CTD PMID:26626330 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO Ritonavir binds to and results in increased activity of NR1I2 protein
Ritonavir results in increased activity of NR1I2 protein		 CTD PMID:14977870 PMID:15849716 PMID:27732639 NCBI chr16:38,068,711...38,115,211
Ensembl chr16:38,068,685...38,115,186 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO Ritonavir results in increased cleavage of PARP1 protein CTD PMID:19386116 PMID:21270666 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Ritonavir results in decreased activity of PON1 protein CTD PMID:27378623 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions
increases expression		 EXP
ISO		 Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG protein]
Ritonavir results in increased expression of PPARG mRNA		 CTD PMID:11101056 PMID:17879945 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions
increases activity
increases expression		 EXP Ritonavir binds to and affects the localization of PRKCA protein
Ritonavir results in increased activity of PRKCA protein
Ritonavir results in increased expression of PRKCA protein		 CTD PMID:22020176 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754 		JBrowse link
G Psma1 proteasome subunit alpha 1 affects expression ISO Ritonavir affects the expression of PSMA1 mRNA CTD PMID:17719200 NCBI chr 7:113,863,785...113,875,351
Ensembl chr 7:113,863,841...113,875,353 		JBrowse link
G Psmb3 proteasome (prosome, macropain) subunit, beta type 3 affects expression ISO Ritonavir affects the expression of PSMB3 mRNA CTD PMID:17719200 NCBI chr11:97,594,260...97,604,326
Ensembl chr11:97,594,225...97,604,326 		JBrowse link
G Psmb5 proteasome (prosome, macropain) subunit, beta type 5 increases expression ISO Ritonavir results in increased expression of PSMB5 mRNA CTD PMID:20213465 NCBI chr14:54,851,577...54,855,452
Ensembl chr14:54,851,576...54,855,479 		JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation
increases expression		 ISO Ritonavir results in decreased phosphorylation of RB1 protein
Ritonavir results in increased expression of RB1 mRNA		 CTD PMID:16551874 PMID:19386116 PMID:21270666 NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262 		JBrowse link
G Rbl1 RB transcriptional corepressor like 1 increases expression ISO Ritonavir results in increased expression of RBL1 mRNA CTD PMID:19386116 NCBI chr 2:156,987,813...157,046,454
Ensembl chr 2:156,987,813...157,046,454 		JBrowse link
G Rbl2 RB transcriptional corepressor like 2 decreases expression ISO Ritonavir results in decreased expression of RBL2 mRNA CTD PMID:19386116 NCBI chr 8:91,796,685...91,850,472
Ensembl chr 8:91,796,685...91,850,472 		JBrowse link
G Rel reticuloendotheliosis oncogene decreases activity ISO Ritonavir results in decreased activity of REL protein CTD PMID:16174765 NCBI chr11:23,686,847...23,720,969
Ensembl chr11:23,686,847...23,720,970 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) decreases activity ISO Ritonavir results in decreased activity of RELA protein CTD PMID:16174765 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions
increases expression		 ISO Estradiol inhibits the reaction [Ritonavir results in increased expression of SCARB1 protein]
Ritonavir results in increased expression of SCARB1 mRNA		 CTD PMID:17879945 NCBI chr 5:125,354,151...125,418,082
Ensembl chr 5:125,354,151...125,418,158 		JBrowse link
G Scp2 sterol carrier protein 2, liver decreases expression ISO Ritonavir results in decreased expression of SCP2 CTD PMID:26626330 NCBI chr 4:107,901,027...108,002,168
Ensembl chr 4:107,901,036...108,002,195 		JBrowse link
G Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 decreases expression ISO Ritonavir results in decreased expression of SLC10A1 CTD PMID:26626330 NCBI chr12:80,999,959...81,015,479
Ensembl chr12:80,999,957...81,015,479 		JBrowse link
G Slc51a solute carrier family 51, alpha subunit decreases expression ISO Ritonavir results in decreased expression of SLC51A CTD PMID:26626330 NCBI chr16:32,294,396...32,306,697
Ensembl chr16:32,293,322...32,306,697 		JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 multiple interactions ISO Ritonavir inhibits the reaction [SLCO4C1 protein affects the transport of traumatic acid] CTD PMID:39041788 NCBI chr 1:96,744,918...96,800,027
Ensembl chr 1:96,743,995...96,799,896 		JBrowse link
G Src Rous sarcoma oncogene decreases phosphorylation ISO Ritonavir results in decreased phosphorylation of SRC protein CTD PMID:21270666 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein] CTD PMID:11101056 NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Ritonavir results in decreased phosphorylation of STAT3 protein CTD PMID:21270666 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Tjp1 tight junction protein 1 decreases expression
multiple interactions		 ISO Ritonavir results in decreased expression of TJP1 protein
[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]		 CTD PMID:20722969 NCBI chr 7:64,945,913...65,177,629
Ensembl chr 7:64,945,913...65,177,529 		JBrowse link
G Tnf tumor necrosis factor decreases secretion
multiple interactions
increases expression		 ISO
EXP		 Ritonavir results in decreased secretion of TNF protein
rosiglitazone inhibits the reaction [Ritonavir results in increased expression of TNF mRNA]
Ritonavir inhibits the reaction [IFNG protein results in increased secretion of TNF protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Ritonavir results in increased expression of TNF mRNA; Ritonavir results in increased expression of TNF protein		 CTD PMID:10551732 PMID:15388451 PMID:15865214 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trp53 transformation related protein 53 multiple interactions
increases expression		 ISO FTI 277 inhibits the reaction [Ritonavir results in increased expression of TP53 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased expression of TP53 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased expression of TP53 protein] CTD PMID:19386116 PMID:20884875 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 affects expression ISO Ritonavir affects the expression of UGT1A1 mRNA CTD PMID:15849716 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719 		JBrowse link
G Zmpste24 zinc metallopeptidase, STE24 decreases activity ISO Ritonavir results in decreased activity of ZMPSTE24 protein CTD PMID:18230615 NCBI chr 4:120,916,434...120,955,452
Ensembl chr 4:120,916,434...120,955,438 		JBrowse link
valine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein increases abundance
multiple interactions		 ISO
EXP		 APP protein mutant form results in increased abundance of Valine
[APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Valine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Valine]
PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of Valine]		 CTD PMID:39172838 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine] CTD PMID:22689575 NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965 		JBrowse link
G Mapt microtubule-associated protein tau increases abundance
multiple interactions		 ISO MAPT protein mutant form results in increased abundance of Valine
PF-06840003 inhibits the reaction [MAPT protein mutant form results in increased abundance of Valine]		 CTD PMID:39172838 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G Psen1 presenilin 1 multiple interactions EXP [APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Valine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Valine] CTD PMID:39172838 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22307
    chemical entity 22306
      molecular entity 22302
        main group molecular entity 22182
          gas molecular entity 19977
            propane 166
              isopropyl group 129
                fragin zwitterion 0
                valine + 129
Path 2
Term Annotations click to browse term
  CHEBI ontology 22307
    subatomic particle 22302
      composite particle 22302
        hadron 22302
          baryon 22302
            nucleon 22302
              atomic nucleus 22302
                atom 22302
                  main group element atom 22182
                    main group molecular entity 22182
                      s-block molecular entity 21770
                        hydrogen molecular entity 21685
                          hydrides 20797
                            organic hydride 20349
                              organic fundamental parent 20349
                                hydrocarbon 19928
                                  alkane 15330
                                    alkyl group 4208
                                      isopropyl group 129
                                        fragin zwitterion 0
                                        valine + 129
paths to the root