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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isopropyl group
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Accession:CHEBI:30353 term browser browse the term
Synonyms:exact_synonym: isopropyl;   propan-2-yl
 related_synonym: (CH3)2CH-;   -CH(CH3)2;   1-methylethyl;   Formula=C3H7;   SMILES=CC(*)C;   iPr;   valine side-chain


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fluvalinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP fluvalinate analog promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:25684042 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G CDK2 cyclin dependent kinase 2 affects binding EXP fluvalinate binds to CDK2 protein CTD PMID:32278787 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 affects binding EXP fluvalinate binds to CYP3A4 protein CTD PMID:32278787 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 affects binding EXP fluvalinate binds to ERBB2 protein CTD PMID:32278787 NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 affects binding EXP fluvalinate binds to FGFR2 protein CTD PMID:32278787 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458 		JBrowse link
G MMP9 matrix metallopeptidase 9 affects binding EXP fluvalinate binds to MMP9 protein CTD PMID:32278787 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 affects binding EXP fluvalinate binds to NQO1 protein CTD PMID:32278787 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 multiple interactions EXP fluvalinate inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions EXP
ISO		 fluvalinate binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta affects binding EXP fluvalinate binds to PPARD protein CTD PMID:32278787 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G RORA RAR related orphan receptor A affects binding EXP fluvalinate binds to RORA protein CTD PMID:32278787 NCBI chr15:60,488,284...61,229,302
Ensembl chr15:60,488,284...61,229,302 		JBrowse link
G RORC RAR related orphan receptor C affects binding EXP fluvalinate binds to RORC protein CTD PMID:32278787 NCBI chr 1:151,806,071...151,831,802
Ensembl chr 1:151,806,071...151,831,845 		JBrowse link
ledipasvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) affects binding EXP ledipasvir binds to ABCG2 protein CTD PMID:33954893 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628 		JBrowse link
G KLRC1 killer cell lectin like receptor C1 decreases expression EXP ledipasvir co-treated with sofosbuvir decreases expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr12:10,442,264...10,454,685
Ensembl chr12:10,442,264...10,454,685 		JBrowse link
G NCR1 natural cytotoxicity triggering receptor 1 affects expression EXP ledipasvir co-treated sofosbuvir with affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr19:54,898,198...54,938,208
Ensembl chr19:54,906,148...54,916,140 		JBrowse link
ritonavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP hyperforin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] CTD PMID:15266218 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions		 EXP Ritonavir results in decreased activity of ABCB11 protein
Ritonavir inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]		 CTD PMID:20829430 PMID:22646477 PMID:23956101 PMID:24014644 PMID:28437613 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 decreases expression
decreases activity		 EXP Ritonavir results in decreased expression of ABCB4
Ritonavir results in decreased activity of ABCB4 protein		 CTD PMID:26626330 PMID:28437613 NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435 		JBrowse link
G ACSS2 acyl-CoA synthetase short chain family member 2 affects expression ISO Ritonavir affects the expression of ACSS2 mRNA CTD PMID:17719200 NCBI chr20:34,874,989...34,927,959
Ensembl chr20:34,872,146...34,927,962 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing decreases expression
multiple interactions		 ISO
EXP		 Ritonavir results in decreased expression of ADIPOQ mRNA; Ritonavir results in decreased expression of ADIPOQ protein
rosiglitazone inhibits the reaction [Ritonavir results in decreased secretion of ADIPOQ protein]
diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of ADIPOQ protein]		 CTD PMID:15865214 PMID:17668557 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 increases phosphorylation ISO Ritonavir results in increased phosphorylation of AKT1 protein CTD PMID:36198369 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G ALB albumin affects binding EXP Ritonavir binds to ALB protein CTD PMID:15814459 PMID:16336266 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G BAK1 BCL2 antagonist/killer 1 increases expression EXP Ritonavir results in increased expression of BAK1 protein CTD PMID:19386116 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Ritonavir results in decreased expression of BCL2 protein CTD PMID:19386116 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP Ritonavir results in decreased expression of BCL2L1 mRNA CTD PMID:16174765 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression EXP Ritonavir results in decreased expression of BIRC5 mRNA; Ritonavir results in decreased expression of BIRC5 protein CTD PMID:16174765 PMID:21270666 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636 		JBrowse link
G CASP1 caspase 1 decreases expression EXP Ritonavir results in decreased expression of CASP1 protein CTD PMID:10551732 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CASP3 caspase 3 decreases activity EXP Ritonavir results in decreased activity of CASP3 protein CTD PMID:10551732 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
increases expression
increases secretion
decreases expression		 EXP diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of CCL2 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of CCL2 protein]
Ritonavir results in decreased expression of CCL2		 CTD PMID:17668557 PMID:20884875 PMID:26626330 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL20 C-C motif chemokine ligand 20 decreases expression EXP Ritonavir results in decreased expression of CCL20 CTD PMID:26626330 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564 		JBrowse link
G CCL3 C-C motif chemokine ligand 3 decreases expression
increases expression		 EXP Ritonavir results in decreased expression of CCL3
Ritonavir results in increased expression of CCL3 protein		 CTD PMID:17668557 PMID:26626330 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 decreases expression EXP Ritonavir results in decreased expression of CCL4 CTD PMID:26626330 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621 		JBrowse link
G CCNA2 cyclin A2 decreases expression EXP Ritonavir results in decreased expression of CCNA2 mRNA CTD PMID:19386116 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCNB1 cyclin B1 decreases expression EXP Ritonavir results in decreased expression of CCNB1 mRNA CTD PMID:19386116 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCND1 cyclin D1 decreases expression EXP Ritonavir results in decreased expression of CCND1 protein CTD PMID:16551874 PMID:21270666 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCND2 cyclin D2 decreases expression EXP Ritonavir results in decreased expression of CCND2 mRNA CTD PMID:16174765 PMID:19386116 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353 		JBrowse link
G CCNE2 cyclin E2 decreases expression EXP Ritonavir results in decreased expression of CCNE2 mRNA CTD PMID:19386116 NCBI chr 8:94,880,224...94,896,693
Ensembl chr 8:94,879,770...94,896,678 		JBrowse link
G CDK2 cyclin dependent kinase 2 decreases expression EXP Ritonavir results in decreased expression of CDK2 mRNA; Ritonavir results in decreased expression of CDK2 protein CTD PMID:16551874 PMID:19386116 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789 		JBrowse link
G CDK3 cyclin dependent kinase 3 increases expression EXP Ritonavir results in increased expression of CDK3 mRNA CTD PMID:19386116 NCBI chr17:76,000,855...76,005,998
Ensembl chr17:76,000,855...76,005,999 		JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP Ritonavir results in decreased expression of CDK4 mRNA; Ritonavir results in decreased expression of CDK4 protein CTD PMID:16551874 PMID:19386116 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013 		JBrowse link
G CDK5 cyclin dependent kinase 5 decreases expression EXP Ritonavir results in decreased expression of CDK5 mRNA CTD PMID:19386116 NCBI chr 7:151,053,815...151,057,897
Ensembl chr 7:151,053,815...151,057,897 		JBrowse link
G CDK6 cyclin dependent kinase 6 decreases expression EXP Ritonavir results in decreased expression of CDK6 mRNA; Ritonavir results in decreased expression of CDK6 protein CTD PMID:16551874 PMID:19386116 NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression
multiple interactions		 EXP Ritonavir results in increased expression of CDKN1A mRNA; Ritonavir results in increased expression of CDKN1A protein
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased expression of CDKN1A protein]		 CTD PMID:19386116 PMID:20884875 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP Ritonavir results in increased expression of CDKN1B mRNA CTD PMID:19386116 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B increases expression EXP Ritonavir results in increased expression of CDKN2B mRNA CTD PMID:19386116 NCBI chr 9:22,002,903...22,009,313
Ensembl chr 9:22,002,903...22,009,305 		JBrowse link
G CEBPA CCAAT enhancer binding protein alpha multiple interactions ISO Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CEBPA protein] CTD PMID:11101056 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534 		JBrowse link
G CIITA class II major histocompatibility complex transactivator increases expression EXP Ritonavir results in increased expression of CIITA CTD PMID:26626330 NCBI chr16:10,866,206...10,943,021
Ensembl chr16:10,866,222...10,943,021 		JBrowse link
G CROT carnitine O-octanoyltransferase decreases expression ISO Ritonavir results in decreased expression of CROT mRNA CTD PMID:17719200 NCBI chr 7:87,345,664...87,399,794
Ensembl chr 7:87,345,664...87,399,794 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 decreases expression EXP Ritonavir results in decreased expression of CXCL1 CTD PMID:26626330 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 decreases expression EXP Ritonavir results in decreased expression of CXCL10 CTD PMID:26626330 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 decreases expression EXP Ritonavir results in decreased expression of CXCL12 CTD PMID:26626330 NCBI chr10:44,370,165...44,385,097
Ensembl chr10:44,370,165...44,386,493 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 decreases expression EXP Ritonavir results in decreased expression of CXCL2 CTD PMID:26626330 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CXCL5 C-X-C motif chemokine ligand 5 decreases expression EXP Ritonavir results in decreased expression of CXCL5 CTD PMID:26626330 NCBI chr 4:73,995,642...73,998,677
Ensembl chr 4:73,995,642...73,998,677 		JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 decreases expression EXP Ritonavir results in decreased expression of CXCL6 CTD PMID:26626330 NCBI chr 4:73,836,678...73,838,760
Ensembl chr 4:73,836,640...73,849,064 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
decreases expression
increases secretion		 EXP Pravastatin inhibits the reaction [Ritonavir results in increased secretion of CXCL8 protein]
Ritonavir results in decreased expression of CXCL8		 CTD PMID:20884875 PMID:26626330 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CYB5R3 cytochrome b5 reductase 3 affects expression ISO Ritonavir affects the expression of CYB5R3 mRNA CTD PMID:17719200 NCBI chr22:42,617,840...42,649,392
Ensembl chr22:42,615,730...42,720,870 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression
decreases activity		 EXP Ritonavir results in increased expression of CYP1A1 mRNA
Ritonavir results in decreased activity of CYP1A1 protein		 CTD PMID:11918509 PMID:33814510 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 increases expression
decreases expression		 EXP
ISO		 Ritonavir results in increased expression of CYP1A2 mRNA
Ritonavir results in decreased expression of CYP1A2 mRNA		 CTD PMID:11918509 PMID:17719200 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 decreases activity EXP Ritonavir results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases activity
increases expression		 EXP Ritonavir results in increased activity of CYP2B6 protein
Ritonavir results in increased expression of CYP2B6 protein		 CTD PMID:14977870 PMID:26626330 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 increases expression EXP Ritonavir results in increased expression of CYP2C19 mRNA CTD PMID:11918509 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 decreases activity EXP Ritonavir results in decreased activity of CYP2C8 protein CTD PMID:15601807 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases activity
increases expression		 EXP Ritonavir results in increased activity of CYP2C9 protein
Ritonavir results in increased expression of CYP2C9 mRNA		 CTD PMID:11918509 PMID:19202563 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene) affects metabolic processing EXP CYP2D6 protein affects the metabolism of Ritonavir CTD PMID:15286053 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 affects metabolic processing
affects binding
increases expression
decreases activity		 EXP CYP3A4 protein affects the metabolism of Ritonavir
CYP3A4 protein binds to Ritonavir analog
Ritonavir results in increased expression of CYP3A4 mRNA
Ritonavir results in decreased activity of CYP3A4 protein		 CTD PMID:15286053 PMID:15523003 PMID:15860655 PMID:16837568 PMID:26626330 More... NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 decreases activity EXP Ritonavir results in decreased activity of CYP3A5 protein CTD PMID:15523003 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 multiple interactions EXP Ritonavir inhibits the reaction [CYP3A7 protein results in increased oxidation of Dehydroepiandrosterone Sulfate] CTD PMID:33821626 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196 		JBrowse link
G CYP4B1 cytochrome P450 family 4 subfamily B member 1 affects expression
decreases expression		 ISO Ritonavir affects the expression of CYP4B1 mRNA
Ritonavir results in decreased expression of CYP4B1 mRNA		 CTD PMID:17719200 NCBI chr 1:46,799,046...46,819,413
Ensembl chr 1:46,757,838...46,819,413 		JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 increases expression ISO Ritonavir results in increased expression of CYP51 mRNA CTD PMID:17719200 NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,084,987...92,134,803 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP
ISO		 Ritonavir results in decreased expression of CYP7A1 mRNA CTD PMID:17719200 PMID:26626330 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G CYP8B1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP
ISO		 Ritonavir results in decreased expression of CYP8B1
Ritonavir results in decreased expression of CYP8B1 mRNA		 CTD PMID:17719200 PMID:26626330 NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898 		JBrowse link
G DHCR7 7-dehydrocholesterol reductase affects expression ISO Ritonavir affects the expression of DHCR7 mRNA CTD PMID:17719200 NCBI chr11:71,427,287...71,449,043
Ensembl chr11:71,428,193...71,452,868 		JBrowse link
G E2F1 E2F transcription factor 1 decreases expression EXP Ritonavir results in decreased expression of E2F1 mRNA; Ritonavir results in decreased expression of E2F1 protein CTD PMID:19386116 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385 		JBrowse link
G E2F2 E2F transcription factor 2 decreases expression EXP Ritonavir results in decreased expression of E2F2 mRNA CTD PMID:19386116 NCBI chr 1:23,505,212...23,531,233
Ensembl chr 1:23,506,438...23,531,233 		JBrowse link
G E2F3 E2F transcription factor 3 decreases expression EXP Ritonavir results in decreased expression of E2F3 mRNA CTD PMID:19386116 NCBI chr 6:20,401,879...20,493,714
Ensembl chr 6:20,401,879...20,493,714 		JBrowse link
G EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase affects expression ISO Ritonavir affects the expression of EHHADH mRNA CTD PMID:17719200 NCBI chr 3:185,190,624...185,254,049
Ensembl chr 3:185,190,624...185,281,990 		JBrowse link
G ESR1 estrogen receptor 1 decreases expression EXP Ritonavir results in decreased expression of ESR1 protein CTD PMID:16551874 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G FASLG Fas ligand decreases expression EXP Ritonavir results in decreased expression of FASLG protein CTD PMID:10551732 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FASN fatty acid synthase affects expression ISO Ritonavir affects the expression of FASN mRNA CTD PMID:17719200 NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294 		JBrowse link
G FGF19 fibroblast growth factor 19 increases expression EXP Ritonavir results in increased expression of FGF19 mRNA CTD PMID:26626330 NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Ritonavir results in increased expression of FOS protein CTD PMID:15504750 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190 		JBrowse link
G GLB1 galactosidase beta 1 multiple interactions
increases activity		 EXP Acetylcysteine inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; FTI 277 inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein] CTD PMID:20884875 NCBI chr 3:32,961,108...33,097,146
Ensembl chr 3:32,996,609...33,097,202 		JBrowse link
G GPD1 glycerol-3-phosphate dehydrogenase 1 multiple interactions ISO Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of GPD1 protein] CTD PMID:11101056 NCBI chr12:50,104,008...50,111,313
Ensembl chr12:50,103,982...50,111,313 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression		 EXP 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Acetylcysteine inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Bilirubin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Dactinomycin inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [Ritonavir results in increased expression of ICAM1 protein]; NFE2L2 protein mutant form inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]; Ritonavir promotes the reaction [Atazanavir Sulfate results in increased expression of HMOX1 mRNA]; Ritonavir promotes the reaction [HMOX1 protein results in increased chemical synthesis of Bilirubin]; Ritonavir promotes the reaction [Lopinavir results in increased expression of HMOX1 mRNA]; Rotenone inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [Ritonavir results in increased expression of HMOX1 protein]; tricarbonyldichlororuthenium (II) dimer promotes the reaction [Ritonavir results in increased expression of HMOX1 protein]
Ritonavir results in increased expression of HMOX1 mRNA; Ritonavir results in increased expression of HMOX1 protein		 CTD PMID:15504750 PMID:26968795 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 affects response to substance ISO HSP90AA1 protein affects the susceptibility to Ritonavir CTD PMID:16551874 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699 		JBrowse link
G HSPH1 heat shock protein family H (Hsp110) member 1 increases expression EXP Ritonavir results in increased expression of HSPH1 protein CTD PMID:26626330 NCBI chr13:31,134,973...31,162,388
Ensembl chr13:31,134,973...31,162,388 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions
increases expression		 EXP HMOX1 protein inhibits the reaction [Ritonavir results in increased expression of ICAM1 protein] CTD PMID:26968795 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNG interferon gamma multiple interactions EXP Ritonavir inhibits the reaction [IFNG protein results in increased secretion of TNF protein] CTD PMID:10551732 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL32 interleukin 32 decreases expression EXP Ritonavir results in decreased expression of IL32 CTD PMID:26626330 NCBI chr16:3,065,403...3,069,530
Ensembl chr16:3,065,297...3,082,192 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression
increases secretion		 EXP
ISO		 diphenyleneiodonium inhibits the reaction [Ritonavir results in increased expression of IL6 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of IL6 protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
rosiglitazone inhibits the reaction [Ritonavir results in increased expression of IL6 mRNA]
Ritonavir results in increased expression of IL6 mRNA; Ritonavir results in increased expression of IL6 protein		 CTD PMID:15388451 PMID:15865214 PMID:17668557 PMID:20884875 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IL7 interleukin 7 decreases expression EXP Ritonavir results in decreased expression of IL7 CTD PMID:26626330 NCBI chr 8:78,675,044...78,805,463
Ensembl chr 8:78,675,743...78,805,523 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of CEBPA protein]; Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG protein]; Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of GPD1 protein]; Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein] CTD PMID:11101056 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Ritonavir results in increased expression of JUN protein CTD PMID:15504750 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G LEP leptin multiple interactions
decreases expression		 EXP diphenyleneiodonium inhibits the reaction [Ritonavir results in decreased expression of LEP protein] CTD PMID:17668557 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G LIF LIF interleukin 6 family cytokine decreases expression EXP Ritonavir results in decreased expression of LIF CTD PMID:26626330 NCBI chr22:30,240,453...30,246,759
Ensembl chr22:30,240,453...30,246,759 		JBrowse link
G LMNA lamin A/C increases expression
increases farnesylation		 EXP Ritonavir results in increased expression of LMNA protein
Ritonavir results in increased farnesylation of LMNA protein alternative form		 CTD PMID:18230615 PMID:20884875 NCBI chr 1:156,082,573...156,140,081
Ensembl chr 1:156,082,572...156,140,081 		JBrowse link
G LPL lipoprotein lipase affects expression ISO Ritonavir affects the expression of LPL mRNA CTD PMID:11741158 NCBI chr 8:19,939,253...19,967,259
Ensembl chr 8:19,901,717...19,967,259 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP Ritonavir results in decreased expression of MYC mRNA CTD PMID:16174765 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression		 EXP NFE2L2 protein mutant form inhibits the reaction [Ritonavir results in increased expression of HMOX1 mRNA]
Ritonavir results in increased expression of NFE2L2 protein		 CTD PMID:26968795 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 decreases activity EXP Ritonavir results in decreased activity of NFKB1 protein CTD PMID:16174765 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha decreases phosphorylation EXP Ritonavir results in decreased phosphorylation of NFKBIA protein CTD PMID:16174765 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NLRC5 NLR family CARD domain containing 5 decreases expression EXP Ritonavir results in decreased expression of NLRC5 CTD PMID:26626330 NCBI chr16:56,989,557...57,083,520
Ensembl chr16:56,989,485...57,083,531 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
decreases expression		 EXP Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA] CTD PMID:22037733 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G NOTCH4 notch receptor 4 decreases expression
multiple interactions		 ISO Ritonavir results in decreased expression of NOTCH4 protein
[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of NOTCH4 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of NOTCH4 protein]		 CTD PMID:20722969 NCBI chr 6:32,194,843...32,224,067
Ensembl chr 6:32,194,843...32,224,067 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 increases expression EXP Ritonavir increases expression of NR1H3 mRNA in macrophages RGD PMID:18849545 RGD:401842387 NCBI chr11:47,248,300...47,269,033
Ensembl chr11:47,248,300...47,269,033 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 increases expression EXP Ritonavir results in increased expression of NR1H4 mRNA CTD PMID:26626330 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 multiple interactions
increases activity		 EXP
ISO		 Ritonavir binds to and results in increased activity of NR1I2 protein
Ritonavir results in increased activity of NR1I2 protein		 CTD PMID:14977870 PMID:15849716 PMID:27732639 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP Ritonavir results in increased cleavage of PARP1 protein CTD PMID:19386116 PMID:21270666 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PON1 paraoxonase 1 decreases activity ISO Ritonavir results in decreased activity of PON1 protein CTD PMID:27378623 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
increases expression		 ISO
EXP		 Ritonavir inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased expression of PPARG protein]
Ritonavir results in increased expression of PPARG mRNA		 CTD PMID:11101056 PMID:17879945 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PRKCA protein kinase C alpha multiple interactions
increases activity
increases expression		 ISO Ritonavir binds to and affects the localization of PRKCA protein
Ritonavir results in increased activity of PRKCA protein
Ritonavir results in increased expression of PRKCA protein		 CTD PMID:22020176 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743 		JBrowse link
G PSMA1 proteasome 20S subunit alpha 1 affects expression ISO Ritonavir affects the expression of PSMA1 mRNA CTD PMID:17719200 NCBI chr11:14,504,876...14,643,662
Ensembl chr11:14,504,211...14,643,635 		JBrowse link
G PSMB3 proteasome 20S subunit beta 3 affects expression ISO Ritonavir affects the expression of PSMB3 mRNA CTD PMID:17719200 NCBI chr17:38,752,741...38,764,225
Ensembl chr17:38,752,741...38,764,225 		JBrowse link
G PSMB5 proteasome 20S subunit beta 5 increases expression ISO Ritonavir results in increased expression of PSMB5 mRNA CTD PMID:20213465 NCBI chr14:23,025,851...23,035,220
Ensembl chr14:23,016,543...23,035,230 		JBrowse link
G RB1 RB transcriptional corepressor 1 decreases phosphorylation
increases expression		 EXP Ritonavir results in decreased phosphorylation of RB1 protein
Ritonavir results in increased expression of RB1 mRNA		 CTD PMID:16551874 PMID:19386116 PMID:21270666 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436 		JBrowse link
G RBL1 RB transcriptional corepressor like 1 increases expression EXP Ritonavir results in increased expression of RBL1 mRNA CTD PMID:19386116 NCBI chr20:36,996,349...37,095,997
Ensembl chr20:36,996,349...37,095,997 		JBrowse link
G RBL2 RB transcriptional corepressor like 2 decreases expression EXP Ritonavir results in decreased expression of RBL2 mRNA CTD PMID:19386116 NCBI chr16:53,434,471...53,491,648
Ensembl chr16:53,433,977...53,491,648 		JBrowse link
G REL REL proto-oncogene, NF-kB subunit decreases activity EXP Ritonavir results in decreased activity of REL protein CTD PMID:16174765 NCBI chr 2:60,881,574...60,931,612
Ensembl chr 2:60,881,491...60,931,612 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases activity EXP Ritonavir results in decreased activity of RELA protein CTD PMID:16174765 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SCARB1 scavenger receptor class B member 1 multiple interactions
increases expression		 EXP Estradiol inhibits the reaction [Ritonavir results in increased expression of SCARB1 protein]
Ritonavir results in increased expression of SCARB1 mRNA		 CTD PMID:17879945 NCBI chr12:124,776,856...124,863,864
Ensembl chr12:124,776,856...124,882,668 		JBrowse link
G SCP2 sterol carrier protein 2 decreases expression EXP Ritonavir results in decreased expression of SCP2 CTD PMID:26626330 NCBI chr 1:52,927,276...53,051,698
Ensembl chr 1:52,927,276...53,051,698 		JBrowse link
G SLC10A1 solute carrier family 10 member 1 decreases expression EXP Ritonavir results in decreased expression of SLC10A1 CTD PMID:26626330 NCBI chr14:69,775,416...69,797,241
Ensembl chr14:69,775,416...69,797,241 		JBrowse link
G SLC51A solute carrier family 51 member A decreases expression EXP Ritonavir results in decreased expression of SLC51A CTD PMID:26626330 NCBI chr 3:196,216,534...196,233,427
Ensembl chr 3:196,211,487...196,243,178 		JBrowse link
G SLCO4C1 solute carrier organic anion transporter family member 4C1 multiple interactions EXP Ritonavir inhibits the reaction [SLCO4C1 protein affects the transport of traumatic acid] CTD PMID:39041788 NCBI chr 5:102,233,986...102,296,284
Ensembl chr 5:102,233,986...102,296,284 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation EXP Ritonavir results in decreased phosphorylation of SRC protein CTD PMID:21270666 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Ritonavir promotes the reaction [[INS1 protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of SREBF1 protein] CTD PMID:11101056 NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 decreases phosphorylation EXP Ritonavir results in decreased phosphorylation of STAT3 protein CTD PMID:21270666 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G TJP1 tight junction protein 1 decreases expression
multiple interactions		 ISO Ritonavir results in decreased expression of TJP1 protein
[Saquinavir co-treated with Nicotine co-treated with Ritonavir] results in decreased expression of TJP1 protein; Vitamin E inhibits the reaction [[Nicotine co-treated with Ritonavir co-treated with Saquinavir] results in decreased expression of TJP1 protein]		 CTD PMID:20722969 NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,915 		JBrowse link
G TNF tumor necrosis factor decreases secretion
multiple interactions
increases expression		 EXP
ISO		 Ritonavir results in decreased secretion of TNF protein
rosiglitazone inhibits the reaction [Ritonavir results in increased expression of TNF mRNA]
Ritonavir inhibits the reaction [IFNG protein results in increased secretion of TNF protein]; Ritonavir inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Ritonavir results in increased expression of TNF mRNA; Ritonavir results in increased expression of TNF protein		 CTD PMID:10551732 PMID:15388451 PMID:15865214 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression		 EXP FTI 277 inhibits the reaction [Ritonavir results in increased expression of TP53 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Ritonavir results in increased expression of TP53 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased expression of TP53 protein] CTD PMID:19386116 PMID:20884875 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 affects expression EXP Ritonavir affects the expression of UGT1A1 mRNA CTD PMID:15849716 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G ZMPSTE24 zinc metallopeptidase STE24 decreases activity EXP Ritonavir results in decreased activity of ZMPSTE24 protein CTD PMID:18230615 NCBI chr 1:40,258,236...40,294,180
Ensembl chr 1:40,258,041...40,294,180 		JBrowse link
valine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein increases abundance
multiple interactions		 EXP
ISO		 APP protein mutant form results in increased abundance of Valine
PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of Valine]
[APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Valine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Valine]		 CTD PMID:39172838 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G EGF epidermal growth factor multiple interactions ISO [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine] CTD PMID:22689575 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766 		JBrowse link
G MAPT microtubule associated protein tau increases abundance
multiple interactions		 EXP MAPT protein mutant form results in increased abundance of Valine
PF-06840003 inhibits the reaction [MAPT protein mutant form results in increased abundance of Valine]		 CTD PMID:39172838 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334 		JBrowse link
G PSEN1 presenilin 1 multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Valine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Valine] CTD PMID:39172838 NCBI chr14:73,136,417...73,223,691
Ensembl chr14:73,136,418...73,223,691 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26503
    chemical entity 26483
      molecular entity 26465
        main group molecular entity 26216
          gas molecular entity 20770
            propane 169
              isopropyl group 132
                fragin zwitterion 0
                valine + 132
Path 2
Term Annotations click to browse term
  CHEBI ontology 26503
    subatomic particle 26479
      composite particle 26479
        hadron 26479
          baryon 26479
            nucleon 26479
              atomic nucleus 26479
                atom 26479
                  main group element atom 26216
                    main group molecular entity 26216
                      s-block molecular entity 25453
                        hydrogen molecular entity 24860
                          hydrides 23080
                            organic hydride 22044
                              organic fundamental parent 22044
                                hydrocarbon 21483
                                  alkane 15696
                                    alkyl group 4430
                                      isopropyl group 132
                                        fragin zwitterion 0
                                        valine + 132
paths to the root