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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:benomyl
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Accession:CHEBI:3015 term browser browse the term
Definition:A member of the class of benzimidazoles that is the methyl ester of [1-(butylcarbamoyl)-1H-benzimidazol-2-yl]carbamic acid. A foliar fungicide used to control a wide range of Ascomycetes and Fungi Imperfecti in a wide range of crops.
Synonyms:related_synonym: 1-(Butylcarbamoyl)-2-benzimidazol-methylcarbamat;   1-(Butylcarbamoyl)-2-benzimidazolecarbamic acid, methyl ester;   1-(N-Butylcarbamoyl)-2-(methoxy-carboxamido)-benzimidazol;   Benlate;   Methyl 1-(butylamino)carbonyl-1H-benzimidazol-2-ylcarbamate;   Methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate;   Methyl N-(1-butylcarbamoyl-2-benzimidazole)carbamate;   methyl [1-(butylcarbamoyl)-1H-benzimidazol-2-yl]carbamate
 xref: CAS:17804-35-2;   HMDB:HMDB0031767
 xref_mesh: MESH:D001542
 xref: PPDB:66;   Pesticides:benomyl;   Reaxys:825455;   kegg.compound:C10896;   pubmed:15813220;   pubmed:16903866;   pubmed:19049291;   pubmed:24693254;   pubmed:24782104;   pubmed:25045800;   pubmed:25104429;   pubmed:25145128;   wikipedia.en:Benomyl
 chemrof_formula: C14H18N4O3
 chemrof_smiles: CCCCNC(=O)n1c(NC(=O)OC)nc2ccccc21
 chemrof_inchi: InChI=1S/C14H18N4O3/c1-3-4-9-15-13(19)18-11-8-6-5-7-10(11)16-12(18)17-14(20)21-2/h5-8H,3-4,9H2,1-2H3,(H,15,19)(H,16,17,20)
 chemrof_inchikey: RIOXQFHNBCKOKP-UHFFFAOYSA-N


show annotations for term's descendants           Sort by:
benomyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam33 ADAM metallopeptidase domain 33 multiple interactions
increases expression 		ISO ORMDL3 protein affects the reaction [Benomyl results in increased expression of ADAM33 protein] CTD PMID:27784618 NCBI chr 3:138,715,428...138,736,392
Ensembl chr 3:138,724,046...138,736,347 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression EXP Benomyl results in decreased expression of AKT1 mRNA CTD PMID:33930522 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases activity ISO
EXP 		Benomyl metabolite results in decreased activity of ALDH2 protein; Benomyl results in decreased activity of ALDH2 protein CTD PMID:9585485 PMID:10513990 PMID:11142365 PMID:15331769 PMID:17010440 NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219 		JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 decreases activity EXP Benomyl results in decreased activity of ALDH5A1 protein CTD PMID:17010440 NCBI chr17:40,560,373...40,586,711
Ensembl chr17:40,558,347...40,586,714 		JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 decreases expression EXP Benomyl results in decreased expression of AMPD3 mRNA CTD PMID:15885261 NCBI chr 1:174,319,526...174,364,605
Ensembl chr 1:174,294,867...174,364,608 		JBrowse link
G Ar androgen receptor multiple interactions ISO Benomyl inhibits the reaction [Dihydrotestosterone affects the localization of and results in increased phosphorylation of AR protein] CTD PMID:25324206 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:67,135,317...67,304,467 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Benomyl inhibits the reaction [BCL2 protein binds to BAX protein] CTD PMID:16903866 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases phosphorylation 		ISO Benomyl inhibits the reaction [BCL2 protein binds to BAX protein]
Benomyl results in increased phosphorylation of BCL2 protein 		CTD PMID:16903866 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B increases expression ISO Benomyl results in increased expression of BUB1B protein CTD PMID:16903866 NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:126,017,045...126,069,796 		JBrowse link
G Car2 carbonic anhydrase 2 increases expression EXP Benomyl results in increased expression of CA2 mRNA CTD PMID:15885261 NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 increases expression
multiple interactions 		ISO Benomyl results in increased expression of CCL17 mRNA
ORMDL3 protein affects the reaction [Benomyl results in increased expression of CCL17 mRNA] 		CTD PMID:27784618 NCBI chr19:10,208,120...10,218,340
Ensembl chr19:10,208,120...10,209,895 		JBrowse link
G Ccnb1 cyclin B1 increases response to substance ISO CCNB1 protein results in increased susceptibility to Benomyl CTD PMID:11960377 NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225 		JBrowse link
G Ccnb2 cyclin B2 increases response to substance ISO CCNB2 protein results in increased susceptibility to Benomyl CTD PMID:11960377 NCBI chr 8:79,968,459...79,981,717
Ensembl chr 8:79,968,465...79,981,682 		JBrowse link
G Cd38 CD38 molecule decreases expression EXP Benomyl results in decreased expression of CD38 mRNA CTD PMID:15885261 NCBI chr14:71,384,532...71,424,794
Ensembl chr14:71,384,532...71,424,505 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
multiple interactions 		ISO Benomyl results in decreased expression of CYP17A1 mRNA
Benomyl results in decreased expression of and results in decreased activity of CYP17A1 protein 		CTD PMID:25324206 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
increases expression 		ISO Benomyl results in increased activity of CYP19A1 protein
Benomyl results in increased expression of CYP19A1 mRNA 		CTD PMID:14691014 PMID:25543211 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [Benomyl results in increased expression of DDIT3 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of DDIT3 protein] CTD PMID:27784618 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases expression
multiple interactions 		ISO Benomyl results in increased expression of EIF2AK3 protein
Acetylcysteine inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of EIF2AK3 protein] 		CTD PMID:27784618 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [Benomyl results in increased expression of ERN1 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of ERN1 protein] CTD PMID:27784618 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding 		ISO Benomyl binds to and results in increased activity of ESR1 protein; Benomyl inhibits the reaction [Estradiol binds to ESR1 protein]
Benomyl binds to ESR1 protein 		CTD PMID:14579009 PMID:16626760 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 increases expression EXP Benomyl results in increased expression of FGFR4 mRNA CTD PMID:15885261 NCBI chr17:9,466,686...9,481,423
Ensembl chr17:9,466,692...9,481,389 		JBrowse link
G Gipc1 GIPC PDZ domain containing family, member 1 increases expression EXP Benomyl results in increased expression of GIPC1 mRNA CTD PMID:15885261 NCBI chr19:41,380,125...41,392,078
Ensembl chr19:41,380,125...41,391,725 		JBrowse link
G Glyat glycine-N-acyltransferase increases expression EXP Benomyl results in increased expression of GLYAT mRNA CTD PMID:15885261 NCBI chr 1:219,128,798...219,149,615
Ensembl chr 1:219,128,811...219,150,774 		JBrowse link
G Hdac1 histone deacetylase 1 decreases activity ISO Benomyl results in decreased activity of HDAC1 protein CTD PMID:25543211 NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions 		ISO Benomyl results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [Benomyl results in increased expression of HSPA5 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of HSPA5 protein] 		CTD PMID:27784618 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression EXP Benomyl results in increased expression of HSPB1 mRNA CTD PMID:15885261 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Benomyl inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:18177342 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487 		JBrowse link
G Itga5 integrin subunit alpha 5 decreases expression ISO Benomyl results in decreased expression of ITGA5 mRNA CTD PMID:25530041 NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:136,358,097...136,381,305 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Benomyl results in decreased expression of ITGB1 mRNA CTD PMID:25530041 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269 		JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 multiple interactions ISO Benomyl inhibits the reaction [Dihydrotestosterone results in increased secretion of KLK3 protein] CTD PMID:25324206 NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586 		JBrowse link
G Klk1c8 kallikrein 1-related peptidase C8 decreases expression EXP Benomyl results in decreased expression of KLK1B21 mRNA CTD PMID:15885261 NCBI chr 1:103,684,293...103,688,155
Ensembl chr 1:103,684,293...103,688,155 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression EXP Benomyl results in increased expression of MAPK8 mRNA CTD PMID:33930522 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mir21 microRNA 21 decreases expression EXP Benomyl results in decreased expression of MIR21 mRNA CTD PMID:33930522 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
increases expression
multiple interactions 		ISO Benomyl results in decreased expression of MMP2 mRNA
Benomyl results in increased expression of MMP2 protein
ORMDL3 protein affects the reaction [Benomyl results in increased expression of MMP2 protein] 		CTD PMID:25530041 PMID:27784618 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP
ISO 		Benomyl results in decreased expression of MMP9 protein
Benomyl results in decreased expression of MMP9 mRNA 		CTD PMID:10026946 PMID:25530041 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mmrn1 multimerin 1 increases expression EXP Benomyl results in increased expression of MMRN1 mRNA CTD PMID:15885261 NCBI chr 4:91,205,462...91,280,862
Ensembl chr 4:91,233,240...91,280,861 		JBrowse link
G Msmb microseminoprotein, beta increases expression EXP Benomyl results in increased expression of MSMB mRNA CTD PMID:15885261 NCBI chr16:7,372,803...7,393,406
Ensembl chr16:7,372,819...7,393,405 		JBrowse link
G Mt2 metallothionein 2 increases expression EXP Benomyl results in increased expression of MT2A mRNA CTD PMID:15885261 NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,837,927...10,838,709 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Benomyl inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:17015962 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Benomyl inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389 		JBrowse link
G Or10al27 olfactory receptor family 10 subfamily AL member 27 increases expression EXP Benomyl results in increased expression of OR10AL27 mRNA CTD PMID:15885261 NCBI chr20:794,490...795,491
Ensembl chr20:743,522...816,076 		JBrowse link
G Or13p4 olfactory receptor family 13 subfamily P member 4 increases expression EXP Benomyl results in increased expression of OR13P4 mRNA CTD PMID:15885261 NCBI chr 5:137,502,182...137,503,129
Ensembl chr 5:137,502,182...137,503,129 		JBrowse link
G Or9s23b olfactory receptor family 9 subfamily S member 23B increases expression EXP Benomyl results in increased expression of OR9S23B mRNA CTD PMID:15885261 NCBI chr 9:100,564,786...100,565,757
Ensembl chr 9:100,564,786...100,565,757 		JBrowse link
G Ormdl3 ORMDL sphingolipid biosynthesis regulator 3 multiple interactions
increases expression 		ISO Acetylcysteine inhibits the reaction [Benomyl results in increased expression of ORMDL3 protein]; MitoTEMPO inhibits the reaction [Benomyl results in increased expression of ORMDL3 protein]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of ADAM33 protein]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of CCL17 mRNA]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of CXCL8 mRNA]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of MMP2 protein]; ORMDL3 protein affects the reaction [Benomyl results in increased expression of TSLP mRNA] CTD PMID:27784618 NCBI chr10:84,086,317...84,092,673
Ensembl chr10:84,086,317...84,093,548 		JBrowse link
G Park7 Parkinsonism associated deglycase decreases activity ISO Benomyl results in decreased activity of PARK7 protein CTD PMID:36842454 NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:166,636,552...166,659,825 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Benomyl results in increased cleavage of PARP1 protein CTD PMID:16903866 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO Benomyl results in decreased expression of PLAU mRNA CTD PMID:25530041 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,505,487...3,512,030 		JBrowse link
G Pten phosphatase and tensin homolog increases expression EXP Benomyl results in increased expression of PTEN mRNA CTD PMID:33930522 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression EXP Benomyl results in increased expression of RELA mRNA CTD PMID:33930522 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP Benomyl results in decreased expression of SCD1 mRNA CTD PMID:15885261 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785 		JBrowse link
G Serpine2 serpin family E member 2 increases expression ISO Benomyl results in increased expression of SERPINE2 mRNA CTD PMID:25530041 NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:88,573,149...88,637,202 		JBrowse link
G Sh2d4a SH2 domain containing 4A increases expression EXP Benomyl results in increased expression of SH2D4A mRNA CTD PMID:15885261 NCBI chr16:26,106,721...26,176,069
Ensembl chr16:26,106,730...26,175,974 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Benomyl results in increased expression of TIMP1 mRNA CTD PMID:25530041 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO Benomyl results in increased expression of TIMP2 mRNA CTD PMID:25530041 NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214 		JBrowse link
G Tnf tumor necrosis factor decreases expression EXP Benomyl results in decreased expression of TNF mRNA CTD PMID:33930522 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Benomyl affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tslp thymic stromal lymphopoietin increases expression
multiple interactions 		ISO Benomyl results in increased expression of TSLP mRNA
ORMDL3 protein affects the reaction [Benomyl results in increased expression of TSLP mRNA] 		CTD PMID:27784618 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,720,257...24,728,420 		JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO Benomyl results in increased activity of and results in increased ubiquitination of UBA1 protein CTD PMID:25714994 NCBI chr  X:4,062,216...4,084,192
Ensembl chr  X:4,062,182...4,084,246 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions EXP Benomyl inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]; Benomyl inhibits the reaction [Pentaerythritol Tetranitrate results in increased phosphorylation of VASP protein] CTD PMID:15331769 NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:88,038,037...88,058,650 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      application 20572
        pesticide 18454
          acaricide 13856
            benomyl 59
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  ester 17841
                                    carboxylic ester 17347
                                      carbamate ester 7540
                                        carbamate fungicide 206
                                          benzimidazolylcarbamate fungicide 166
                                            benomyl 59
paths to the root