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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bendroflumethiazide
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Accession:CHEBI:3013 term browser browse the term
Definition:A sulfonamide consisting of 7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by a trifluoromethyl group and that at position 3 is substituted by a benzyl group.
Synonyms:related_synonym: +--3-benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;   6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide;   Formula=C15H14F3N3O4S2;   InChI=1S/C15H14F3N3O4S2/c16-15(17,18)10-7-11-13(8-12(10)26(19,22)23)27(24,25)21-14(20-11)6-9-4-2-1-3-5-9/h1-5,7-8,14,20-21H,6H2,(H2,19,22,23);   InChIKey=HDWIHXWEUNVBIY-UHFFFAOYSA-N;   SMILES=NS(=O)(=O)c1cc2c(NC(Cc3ccccc3)NS2(=O)=O)cc1C(F)(F)F;   bendrofluazide;   bendroflumethiazidum;   bendroflumetiazida;   benzhydroflumethiazide
 alt_id: CHEBI:615239
 xref: CAS:73-48-3;   DrugBank:DB00436;   Drug_Central:305;   KEGG:C07758;   KEGG:D00650;   LINCS:LSM-1816
 xref_mesh: MESH:D001539
 xref: PMID:19056282;   Patent:GB863474;   Patent:US3392168;   Reaxys:373316;   Wikipedia:Bendroflumethiazide


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bendroflumethiazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apob apolipoprotein B affects expression ISO Bendroflumethiazide affects the expression of APOB protein CTD PMID:2344503 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Ren renin increases expression ISO Bendroflumethiazide results in increased expression of REN protein CTD PMID:62162 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
G Slc12a3 solute carrier family 12 member 3 increases response to substance EXP SLC12A3 protein results in increased susceptibility to Bendroflumethiazide CTD PMID:18480177 NCBI chr19:10,630,651...10,679,250
Ensembl chr19:10,631,393...10,669,091 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity
increases secretion		 ISO Bendroflumethiazide results in decreased activity of SLC22A6 protein
SLC22A6 protein results in increased secretion of Bendroflumethiazide		 CTD PMID:18216144 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity
increases secretion		 ISO Bendroflumethiazide results in decreased activity of SLC22A8 protein
SLC22A8 protein results in increased secretion of Bendroflumethiazide		 CTD PMID:18216144 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450 		JBrowse link
G Tpmt thiopurine S-methyltransferase decreases activity ISO Bendroflumethiazide results in decreased activity of TPMT protein CTD PMID:8866635 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709 		JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression EXP Bendroflumethiazide results in decreased expression of VEGFC protein CTD PMID:20625077 NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            diuretic 4108
              bendroflumethiazide 7
                (R)-bendroflumethiazide 0
                (S)-bendroflumethiazide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      chalcogen 19563
                        oxygen atom 19535
                          oxygen molecular entity 19535
                            hydroxides 19341
                              oxoacid 18777
                                chalcogen oxoacid 13781
                                  sulfur oxoacid 13570
                                    sulfonic acid 11616
                                      sulfonic acid derivative 11616
                                        sulfonamide 5307
                                          bendroflumethiazide 7
                                            (R)-bendroflumethiazide 0
                                            (S)-bendroflumethiazide 0
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