azo group - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	azo group	go back to main search page
Accession:	CHEBI:30106	browse the term
Synonyms:	related_synonym:	-N=N-; azo; diazene-1,2-diyl; diazenediyl
	chemrof_smiles:	/N=N/
	chemrof_formula:	N2
	cyclic_relationship:	is_substituent_group_from CHEBI:30096

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Rat (306 ) Mouse (313 ) Human (303 ) Chinchilla (0 ) Bonobo (0 ) Dog (1 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (306)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nuclear receptor subfamily 1, group I, member 3

increases activity

ISO

azobenzene results in increased activity of NR1I3 protein

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

1,1'-azobis(N,N-dimethylformamide)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase copper transporting alpha

multiple interactions

ISO

Diamide promotes the reaction [CLU protein binds to ATP7A protein]

NCBI chr X:75,159,635...75,267,094
Ensembl chr X:75,159,782...75,267,093

G

ATPase copper transporting beta

multiple interactions

ISO

Diamide promotes the reaction [CLU protein binds to ATP7B protein]

NCBI chr16:76,654,725...76,726,092
Ensembl chr16:76,653,660...76,728,801

G

CF transmembrane conductance regulator

multiple interactions

ISO

[Glutathione co-treated with Diamide] results in decreased activity of CFTR protein

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

clusterin

multiple interactions

ISO

Diamide promotes the reaction [CLU protein binds to ATP7A protein]; Diamide promotes the reaction [CLU protein binds to ATP7B protein]

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

glutamate-cysteine ligase, catalytic subunit

increases activity
increases expression

EXP

Diamide results in increased activity of GCLC protein
Diamide results in increased expression of GCLC mRNA; Diamide results in increased expression of GCLC protein

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

increases expression

EXP

Diamide results in increased expression of GCLM mRNA; Diamide results in increased expression of GCLM protein

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

heme oxygenase 1

increases expression

ISO

Diamide results in increased expression of HMOX1 protein

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

interleukin 1 alpha

multiple interactions

ISO

Diamide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Diamide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

microsomal glutathione S-transferase 1

multiple interactions
increases activity

EXP

[Diamide co-treated with Glutathione] results in increased activity of MGST1 protein; Bongkrekic Acid inhibits the reaction [[Diamide co-treated with Glutathione] results in increased activity of MGST1 protein]; Cyclosporine inhibits the reaction [[Diamide co-treated with Glutathione] results in increased activity of MGST1 protein]
Diamide results in increased activity of MGST1 protein

NCBI chr 4:172,760,930...172,776,157
Ensembl chr 4:172,760,886...172,776,875

G

mechanistic target of rapamycin kinase

multiple interactions
increases activity

ISO

[Diamide results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; Diamide inhibits the reaction [MTOR protein binds to RPTOR protein]; MTOR mutant form inhibits the reaction [Diamide results in increased phosphorylation of RPS6KB1 protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

NFE2 like bZIP transcription factor 2

affects response to substance

ISO

[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Diamide

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

oxoglutarate dehydrogenase

multiple interactions

EXP

Glutathione promotes the reaction [Diamide results in decreased activity of OGDH protein]

NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271

G

8-oxoguanine DNA glycosylase

multiple interactions

ISO

Diamide results in increased oxidation of and results in decreased activity of OGG1 protein

NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:148,030,349...148,037,604

G

peptidylprolyl isomerase F

increases oxidation

ISO
EXP

Diamide results in increased oxidation of PPIF protein

NCBI chr16:1,264,001...1,270,722
Ensembl chr16:1,263,541...1,316,954

G

peroxiredoxin 3

increases oxidation

ISO
EXP

Diamide results in increased oxidation of PRDX3 protein

NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300

G

riboflavin kinase

decreases response to substance

ISO

RFK protein results in decreased susceptibility to Diamide

NCBI chr 1:224,226,632...224,234,185
Ensembl chr 1:224,226,628...224,235,698
Ensembl chr X:224,226,628...224,235,698

G

ribosomal protein S6 kinase B1

increases phosphorylation
multiple interactions

ISO

Diamide results in increased phosphorylation of RPS6KB1 protein
[Diamide results in increased activity of MTOR protein] which results in increased phosphorylation of RPS6KB1 protein; MTOR mutant form inhibits the reaction [Diamide results in increased phosphorylation of RPS6KB1 protein]; RPTOR mutant form inhibits the reaction [Diamide results in increased phosphorylation of RPS6KB1 protein]

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

regulatory associated protein of MTOR, complex 1

multiple interactions

ISO

Diamide inhibits the reaction [MTOR protein binds to RPTOR protein]; RPTOR mutant form inhibits the reaction [Diamide results in increased phosphorylation of RPS6KB1 protein]

NCBI chr10:105,376,943...105,675,416
Ensembl chr10:105,376,943...105,675,413

G

superoxide dismutase 2

increases expression
multiple interactions

ISO

Diamide results in increased expression of SOD2 mRNA
Diamide inhibits the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Diamide inhibits the reaction [IL1A protein results in increased expression of SOD2 protein]; Diamide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Diamide inhibits the reaction [TNF protein results in increased expression of SOD2 protein]

PMID:7476933 PMID:8760145

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

signal transducer and activator of transcription 3

affects localization

ISO

Diamide affects the localization of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

tumor necrosis factor

multiple interactions

ISO

Diamide inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]; Diamide inhibits the reaction [TNF protein results in increased expression of SOD2 protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

increases glutathionylation

ISO

Diamide results in increased glutathionylation of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

thioredoxin 1

increases oxidation

ISO

Diamide results in increased oxidation of TXN protein

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307

G

thioredoxin 2

increases oxidation

ISO
EXP

Diamide results in increased oxidation of TXN2 protein

NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:111,386,805...111,390,022

G

XPA, DNA damage recognition and repair factor

decreases activity

ISO

Diamide results in decreased activity of XPA protein

NCBI chr 5:65,227,281...65,275,784
Ensembl chr 5:65,227,281...65,272,425

3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity
multiple interactions
increases activity

EXP

metanil yellow results in decreased activity of ACHE protein
[metanil yellow co-treated with malachite green co-treated with sudan III] results in increased activity of ACHE protein; scutellarin inhibits the reaction [metanil yellow results in decreased activity of ACHE protein]
metanil yellow results in increased activity of ACHE protein

PMID:34419739 PMID:37813177 PMID:39703340

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

albumin

multiple interactions

EXP

[Tartrazine co-treated with metanil yellow co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in increased expression of ALB protein

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

calbindin 1

decreases expression
multiple interactions

EXP

metanil yellow results in decreased expression of CALB1 protein
scutellarin inhibits the reaction [metanil yellow results in decreased expression of CALB1 protein]

NCBI chr 5:34,172,612...34,199,555
Ensembl chr 5:34,172,664...34,200,160

G

caspase 3

multiple interactions
increases cleavage

EXP

scutellarin inhibits the reaction [metanil yellow results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

decreases activity
multiple interactions

EXP

metanil yellow results in decreased activity of CAT protein
[metanil yellow co-treated with malachite green co-treated with sudan III] results in decreased activity of CAT protein; [Tartrazine co-treated with metanil yellow co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in decreased activity of CAT protein; alpha-Tocopherol inhibits the reaction [metanil yellow results in decreased activity of CAT protein]; Ascorbic Acid inhibits the reaction [metanil yellow results in decreased activity of CAT protein]; Eugenol inhibits the reaction [metanil yellow results in decreased activity of CAT protein]

PMID:26494366 PMID:26862277 PMID:30738991 PMID:37813177

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cyclin B1

multiple interactions

EXP

[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCNB1 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

increases expression
multiple interactions

EXP

metanil yellow results in increased expression of CCND1 protein
[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCND1 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CCND1 protein; metanil yellow promotes the reaction [Diethylnitrosamine results in increased expression of CCND1 protein]

PMID:10906429 PMID:12616621

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin E1

multiple interactions
increases expression

EXP

metanil yellow promotes the reaction [Diethylnitrosamine results in increased expression of CCNE1 protein]
metanil yellow results in increased expression of CCNE1 protein

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cyclin-dependent kinase 1

multiple interactions

EXP

[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK1 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK1 protein

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase 4

multiple interactions

EXP

[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK4 mRNA; [Diethylnitrosamine co-treated with metanil yellow] results in increased expression of CDK4 protein

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

follicle stimulating hormone subunit beta

decreases expression

EXP

metanil yellow results in decreased expression of FSHB

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

glial fibrillary acidic protein

increases expression
multiple interactions

EXP

metanil yellow results in increased expression of GFAP protein
scutellarin inhibits the reaction [metanil yellow results in increased expression of GFAP protein]

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

glutamic-oxaloacetic transaminase 1

multiple interactions
increases activity

EXP

alpha-Tocopherol inhibits the reaction [metanil yellow results in increased activity of GOT1 protein]; Ascorbic Acid inhibits the reaction [metanil yellow results in increased activity of GOT1 protein]; Eugenol inhibits the reaction [metanil yellow results in increased activity of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

increases activity
multiple interactions

EXP

metanil yellow results in increased activity of GPT protein
alpha-Tocopherol inhibits the reaction [metanil yellow results in increased activity of GPT protein]; Ascorbic Acid inhibits the reaction [metanil yellow results in increased activity of GPT protein]; Eugenol inhibits the reaction [metanil yellow results in increased activity of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

decreases expression
multiple interactions

EXP

metanil yellow results in decreased expression of GPX1 protein
scutellarin inhibits the reaction [metanil yellow results in decreased expression of GPX1 protein]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione-disulfide reductase

decreases activity

EXP

metanil yellow results in decreased activity of GSR protein

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

interleukin 1 beta

multiple interactions
increases expression

EXP

scutellarin inhibits the reaction [metanil yellow results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

luteinizing hormone subunit beta

decreases expression

EXP

metanil yellow results in decreased expression of LHB

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

monoamine oxidase B

decreases activity

EXP

metanil yellow results in decreased activity of MAOB protein

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

proliferating cell nuclear antigen

multiple interactions
increases expression

EXP

[Diethylnitrosamine co-treated with metanil yellow] results in increased expression of PCNA protein; metanil yellow promotes the reaction [Diethylnitrosamine results in increased expression of PCNA protein]
metanil yellow results in increased expression of PCNA protein

PMID:10906429 PMID:11831363 PMID:12616621

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

superoxide dismutase 1

decreases expression
multiple interactions

EXP

metanil yellow results in decreased expression of SOD1 protein
scutellarin inhibits the reaction [metanil yellow results in decreased expression of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

synaptophysin

multiple interactions
decreases expression

EXP

scutellarin inhibits the reaction [metanil yellow results in decreased expression of SYP protein]

NCBI chr X:17,521,348...17,536,449
Ensembl chr X:17,521,348...17,536,984

G

tumor necrosis factor

multiple interactions
increases expression

EXP

scutellarin inhibits the reaction [metanil yellow results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

3-methyl-4'-dimethylaminoazobenzene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tyrosine aminotransferase

multiple interactions

EXP

Methyldimethylaminoazobenzene inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; Methyldimethylaminoazobenzene inhibits the reaction [Glucocorticoids results in increased expression of TAT mRNA]; Methyldimethylaminoazobenzene inhibits the reaction [Hydrocortisone results in increased activity of TAT protein]

PMID:12882633 PMID:16267830

NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482

4-(dimethylamino)azobenzene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

decreases activity

ISO

p-Dimethylaminoazobenzene results in decreased activity of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

ISO

lac dye inhibits the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

DNA methyltransferase 1

decreases activity

ISO

lac dye results in decreased activity of DNMT1 protein

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

multiple interactions

ISO

lac dye inhibits the reaction [Dietary Fats results in decreased expression of EZH2 mRNA]

NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:77,624,223...77,687,183

G

forkhead box O1

multiple interactions

ISO

lac dye inhibits the reaction [Dietary Fats results in increased expression of and results in decreased phosphorylation of FOXO1 protein]; lac dye inhibits the reaction [Dietary Fats results in increased expression of FOXO1 mRNA]

NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

ISO

lac dye inhibits the reaction [Dietary Fats results in increased expression of G6PC1 mRNA]

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

glutamic--pyruvic transaminase

multiple interactions

ISO

lac dye inhibits the reaction [Dietary Fats results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glycogen synthase kinase 3 beta

multiple interactions

ISO

lac dye inhibits the reaction [Dietary Fats results in decreased phosphorylation of GSK3B protein]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

interleukin 1 beta

multiple interactions

ISO

lac dye inhibits the reaction [Dietary Fats results in increased expression of IL1B mRNA]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

lac dye inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin 1

multiple interactions

ISO

lac dye inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

mitogen activated protein kinase 1

multiple interactions

ISO

lac dye inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

lac dye inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

ISO

lac dye inhibits the reaction [Dietary Fats results in increased expression of PCK1 mRNA]

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

lac dye inhibits the reaction [Dietary Fats results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

tumor necrosis factor

multiple interactions

ISO

lac dye inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

4-Hydroxyazobenzene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 1

increases activity

EXP

4-hydroxyazobenzene results in increased activity of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arginine vasopressin

multiple interactions

EXP

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of AVP protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of AVP protein]

NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522

G

fibronectin 1

decreases expression

ISO

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid results in decreased expression of FN1 mRNA

NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137

G

H2A.X variant histone

multiple interactions

ISO

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]]

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

interleukin 6

multiple interactions

ISO

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Silicon Dioxide analog results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

NADPH oxidase 1

multiple interactions

ISO

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [NOX1 protein promotes the reaction [glycylphenylalanine 2-naphthylamide results in increased export of Calcium]]

NCBI chr X:101,572,338...101,625,571
Ensembl chr X:101,572,340...101,595,520

G

oxytocin/neurophysin I prepropeptide

multiple interactions

EXP

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Phenylephrine co-treated with Adenosine Triphosphate] results in increased secretion of OXT protein]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased secretion of OXT protein]

NCBI chr 3:138,235,754...138,236,594
Ensembl chr 3:138,235,754...138,236,594

G

purinergic receptor P2X 7

multiple interactions

ISO

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX7 protein]
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate binds to and results in increased activity of P2RX7 protein]

PMID:21638035 PMID:31263019

NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193

G

poly (ADP-ribose) polymerase 1

multiple interactions

ISO

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

tumor protein p53 binding protein 1

multiple interactions

ISO

pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of TP53BP1 protein]]

NCBI chr 3:128,620,320...128,724,716
Ensembl chr 3:128,620,322...128,696,747

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nuclear receptor subfamily 1, group I, member 3

increases activity

ISO

azobenzene results in increased activity of NR1I3 protein

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amyloid beta precursor protein

multiple interactions
affects binding

EXP
ISO

Congo Red inhibits the reaction [APP protein binds to APP protein]
Congo Red binds to APP protein

PMID:17323972 PMID:17406451

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

prion protein

decreases expression

ISO

Congo Red results in decreased expression of PRNP protein alternative form

NCBI chr 3:139,639,076...139,654,420
Ensembl chr 3:139,630,144...139,658,436

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-reactive protein

multiple interactions

ISO

[Gemcitabine co-treated with olsalazine] inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of CRP protein]

NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

olsalazine results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

glutamic--pyruvic transaminase

multiple interactions

ISO

[Gemcitabine co-treated with olsalazine] inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

tumor protein p53

multiple interactions

ISO

[Gemcitabine co-treated with olsalazine] inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of TRP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

ortho-Aminoazotoluene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

multiple interactions
increases expression

ISO

NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC2 mRNA]

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 4

multiple interactions
increases expression

ISO

NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC4 mRNA]

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

aryl hydrocarbon receptor

multiple interactions

ISO

AHR protein affects the reaction [o-Aminoazotoluene affects the expression of CYP1A1 mRNA]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

o-Aminoazotoluene results in increased expression of BAX mRNA

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

cyclin G1

increases expression

ISO

o-Aminoazotoluene results in increased expression of CCNG1 mRNA

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

o-Aminoazotoluene results in increased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression
increases activity

ISO

AHR protein affects the reaction [o-Aminoazotoluene affects the expression of CYP1A1 mRNA]
o-Aminoazotoluene results in increased expression of CYP1A1 mRNA
o-Aminoazotoluene results in increased activity of CYP1A1 protein

PMID:10887293 PMID:12700417 PMID:14562683 PMID:15863256

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases activity
increases expression

ISO

o-Aminoazotoluene results in increased activity of CYP1A2 protein
o-Aminoazotoluene results in increased expression of CYP1A2 mRNA

PMID:10887293 PMID:14562683 PMID:15863256

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
multiple interactions

ISO

o-Aminoazotoluene results in increased expression of CYP2B10 mRNA; o-Aminoazotoluene results in increased expression of CYP2B10 protein
NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 protein]

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases expression
multiple interactions

ISO

o-Aminoazotoluene results in increased expression of CYP2C29 mRNA
NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2C29 mRNA]

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

forkhead box A3

decreases activity

ISO

o-Aminoazotoluene results in decreased activity of FOXA3 protein

NCBI chr 1:87,790,111...87,800,259
Ensembl chr 1:87,790,012...87,800,953

G

MDM2 proto-oncogene

increases expression

ISO

o-Aminoazotoluene results in increased expression of MDM2 mRNA

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
increases expression

ISO

NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC protein]
o-Aminoazotoluene results in increased expression of MYC mRNA; o-Aminoazotoluene results in increased expression of MYC protein

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions
increases activity
increases response to substance

ISO

NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC2 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC4 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 protein]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2C29 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP3A11 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC protein]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of UGT1A1 mRNA]
o-Aminoazotoluene results in increased activity of NR1I3 protein
NR1I3 protein results in increased susceptibility to o-Aminoazotoluene

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

tyrosine aminotransferase

multiple interactions

ISO

o-Aminoazotoluene inhibits the reaction [Dexamethasone results in increased expression of TAT mRNA]; o-Aminoazotoluene inhibits the reaction [Glucocorticoids results in increased expression of TAT mRNA]; o-Aminoazotoluene inhibits the reaction [Hydrocortisone results in increased activity of TAT protein]

PMID:11443928 PMID:12882633 PMID:16267830

NCBI chr19:54,856,604...54,867,168
Ensembl chr19:54,856,563...54,867,482

G

tumor protein p53

increases expression

ISO

o-Aminoazotoluene results in increased expression of TRP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

UDP glucuronosyltransferase family 1 member A1

multiple interactions
increases expression

ISO

NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of UGT1A1 mRNA]

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

phenazopyridine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

decreases activity

ISO

Phenazopyridine results in decreased activity of ABCB4 protein

NCBI chr 4:26,106,895...26,164,440

G

utrophin

increases expression

ISO

Phenazopyridine results in increased expression of UTRN mRNA

NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:8,542,798...9,044,487

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbonic anhydrase 3

multiple interactions

ISO

sulfamidochrysoidine binds to and results in decreased activity of CA3 protein

NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524

G

carbonic anhydrase 2

multiple interactions

ISO

sulfamidochrysoidine binds to and results in decreased activity of CA2 protein

NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome b5 type A

multiple interactions

EXP
ISO

CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]
CYB5A protein inhibits the reaction [CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein inhibits the reaction [CYP2C19 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP1A2 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP2A6 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYB5A protein promotes the reaction [CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol]

PMID:17159775 PMID:19358889

NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression
increases oxidation

ISO
EXP

CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYP1A1 protein results in increased metabolism of and results in increased activity of 1-phenylazo-2-naphthol
1-phenylazo-2-naphthol results in increased expression of CYP1A1 mRNA; 1-phenylazo-2-naphthol results in increased expression of CYP1A1 protein
1-phenylazo-2-naphthol promotes the reaction [aristolochic acid I results in increased expression of and results in increased activity of CYP1A1 protein]; 1-phenylazo-2-naphthol results in increased expression of and results in increased activity of CYP1A1 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of CYP1A1 mRNA; [CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1-phenylazo-2-naphthol; CYB5A protein promotes the reaction [CYP1A1 protein results in increased oxidation of 1-phenylazo-2-naphthol]; CYP1A1 protein results in increased metabolism of and results in increased activity of 1-phenylazo-2-naphthol

PMID:12384524 PMID:15766589 PMID:17159775 PMID:18418879 PMID:23289503 More...

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
increases expression
increases oxidation

ISO
EXP

CYB5A protein promotes the reaction [CYP1A2 protein results in increased oxidation of 1-phenylazo-2-naphthol]
1-phenylazo-2-naphthol results in increased expression of CYP1A2 mRNA
1-phenylazo-2-naphthol affects the expression of and affects the activity of CYP1A2 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of CYP1A2 mRNA; [aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in increased expression of and results in increased activity of CYP1A2 protein

PMID:17159775 PMID:26845733

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases oxidation

ISO

CYP1B1 protein results in increased oxidation of 1-phenylazo-2-naphthol

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases oxidation
multiple interactions

ISO

CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol
CYB5A protein inhibits the reaction [CYP2B6 protein results in increased oxidation of 1-phenylazo-2-naphthol]

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, subfamily 2, polypeptide 11

decreases activity
multiple interactions

EXP

1-phenylazo-2-naphthol results in decreased activity of CYP2C11 protein
[aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in decreased activity of CYP2C11 protein

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853

G

cytochrome P450, family 2, subfamily C, polypeptide 6

multiple interactions
increases oxidation

ISO

CYB5A protein inhibits the reaction [CYP2C19 protein results in increased oxidation of 1-phenylazo-2-naphthol]

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily c, polypeptide 79

increases oxidation

ISO

CYP2C8 protein results in increased oxidation of 1-phenylazo-2-naphthol

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
increases oxidation

ISO

CYB5A protein inhibits the reaction [CYP2D6 protein results in increased oxidation of 1-phenylazo-2-naphthol]

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases oxidation

ISO

CYP2E1 protein results in increased oxidation of 1-phenylazo-2-naphthol

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases oxidation
multiple interactions

ISO

CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol
CYB5A protein promotes the reaction [CYP3A4 protein results in increased oxidation of 1-phenylazo-2-naphthol]

PMID:17159775 PMID:19358889

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

coagulation factor III, tissue factor

increases expression

ISO

1-phenylazo-2-naphthol results in increased expression of F3 protein

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

glutathione S-transferase pi 1

increases expression

EXP

1-phenylazo-2-naphthol results in increased expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

EXP

1-phenylazo-2-naphthol results in increased expression of and results in increased activity of NQO1 protein; [1-phenylazo-2-naphthol co-treated with aristolochic acid I] results in increased expression of NQO1 mRNA; [aristolochic acid I co-treated with 1-phenylazo-2-naphthol] results in increased expression of and results in increased activity of NQO1 protein
1-phenylazo-2-naphthol results in increased expression of NQO1 mRNA

PMID:23289503 PMID:26845733

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

cytochrome p450 oxidoreductase

multiple interactions

EXP

[CYP1A1 protein co-treated with POR protein] results in increased metabolism of 1-phenylazo-2-naphthol

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity
multiple interactions
increases activity

EXP

sudan III results in decreased activity of ACHE protein
[metanil yellow co-treated with malachite green co-treated with sudan III] results in increased activity of ACHE protein
sudan III results in increased activity of ACHE protein

PMID:37813177 PMID:39703340

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

aryl hydrocarbon receptor

affects localization
multiple interactions

ISO
EXP

sudan III affects the localization of AHR protein
[sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein]; [sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; sudan III binds to and results in increased activity of AHR protein
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III binds to and results in increased activity of AHR protein

PMID:15585952 PMID:15788368 PMID:22287322

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

ISO

[sudan III affects the localization of AHR protein] promotes the reaction [AHR protein binds to ARNT protein]

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

catalase

multiple interactions
decreases activity

EXP

[metanil yellow co-treated with malachite green co-treated with sudan III] results in decreased activity of CAT protein
sudan III results in decreased activity of CAT protein

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
increases activity
multiple interactions

ISO
EXP

sudan III results in increased expression of CYP1A1 mRNA
sudan III results in increased expression of CYP1A1 mRNA; sudan III results in increased expression of CYP1A1 protein
sudan III results in increased activity of CYP1A1 protein
[sudan III affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA]

PMID:18418879 PMID:20308224 PMID:22287322

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

EXP

sudan III results in increased expression of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions
decreases expression

EXP

[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B1 protein
sudan III results in decreased expression of CYP2B1 mRNA

NCBI chr 1:90,646,098...90,669,762

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions
decreases expression

EXP

[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; sudan III results in decreased expression of and results in decreased activity of CYP2B2 protein
sudan III results in decreased expression of CYP2B2 mRNA

NCBI chr 1:90,722,243...90,736,272

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions
decreases expression

EXP

[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] which results in decreased activity of CYP2C11 protein; sudan III results in decreased expression of and results in decreased activity of CYP2C11 protein
sudan III results in decreased expression of CYP2C11 mRNA

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases expression

EXP

[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; sudan III results in decreased expression of and results in decreased activity of CYP3A2 protein
sudan III results in decreased expression of CYP3A2 mRNA

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

multiple interactions
decreases expression

EXP

[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; sudan III results in decreased expression of and results in decreased activity of CYP3A23-3A1 protein
sudan III results in decreased expression of CYP3A23-3A1 mRNA

NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813

G

cytochrome P450, family 4, subfamily a, polypeptide 1

decreases expression

EXP

sudan III results in decreased expression of CYP4A1 mRNA

NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231

G

cytochrome P450, family 4, subfamily a, polypeptide 2

decreases expression

EXP

sudan III results in decreased expression of CYP4A2 mRNA

NCBI chr 5:134,160,356...134,170,908
Ensembl chr 5:134,160,358...134,176,156

G

cytochrome P450, family 4, subfamily a, polypeptide 3

decreases expression

EXP

sudan III results in decreased expression of CYP4A3 mRNA

NCBI chr 5:134,334,396...134,352,268
Ensembl chr 5:134,334,701...134,352,236

G

monoamine oxidase B

decreases activity

EXP

sudan III results in decreased activity of MAOB protein

NCBI chr X:8,490,405...8,594,065
Ensembl chr X:8,490,344...8,594,375

G

NAD(P)H quinone dehydrogenase 1

increases expression

EXP

sudan III results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

ISO

NR1I3 protein promotes the reaction [sudan III results in increased expression of CYP1A1 mRNA]

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

peroxisome proliferator activated receptor alpha

decreases expression
multiple interactions

ISO
EXP

sudan III results in decreased expression of PPARA protein
sudan III results in decreased expression of PPARA mRNA
[sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased activity of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in decreased expression of CYP2C11 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP2B2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A2 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]

PMID:15585952 PMID:15788368

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

retinoid X receptor alpha

decreases expression

ISO

sudan III results in decreased expression of RXRA protein

NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

EXP

Scarlet Red results in increased expression of CYP1A1 mRNA; Scarlet Red results in increased expression of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminoadipate aminotransferase

increases expression

ISO

Sulfasalazine results in increased expression of AADAT mRNA

NCBI chr16:34,520,236...34,566,388
Ensembl chr16:34,520,238...34,566,540

G

ATP binding cassette subfamily C member 2

multiple interactions

EXP

[Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily G member 2

increases transport
multiple interactions
decreases methylation
affects transport
increases activity

ISO

ABCG2 protein results in increased transport of Sulfasalazine
[Sulfasalazine results in decreased methylation of ABCG2 promoter] which results in increased expression of ABCG2 mRNA; Dactinomycin inhibits the reaction [Sulfasalazine results in increased expression of ABCG2 mRNA]; Sulfasalazine inhibits the reaction [[Adenosine Triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]; Sulfasalazine promotes the reaction [Cholesterol results in increased activity of ABCG2 protein]; yu ping feng san inhibits the reaction [Sulfasalazine results in increased activity of ABCG2 protein]
ABCG2 gene polymorphism affects the transport of Sulfasalazine

PMID:18167504 PMID:18408567 PMID:20019844 PMID:27475308 PMID:30083819 More...

NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493

G

acetyl-Coenzyme A acyltransferase 1B

increases expression

ISO

Sulfasalazine results in increased expression of ACAA1B mRNA

NCBI chr 8:127,750,771...127,759,589
Ensembl chr 8:127,750,743...127,759,569

G

angiotensin converting enzyme 2

decreases expression

ISO

Sulfasalazine results in decreased expression of ACE2 mRNA

NCBI chr X:33,925,458...33,972,851
Ensembl chr X:33,925,458...33,971,596

G

acyl-CoA thioesterase 1

increases expression

ISO

Sulfasalazine results in increased expression of ACOT1 mRNA

NCBI chr 6:109,367,274...109,375,268
Ensembl chr 6:109,367,268...109,380,749

G

acyl-CoA thioesterase 3

increases expression

ISO

Sulfasalazine results in increased expression of ACOT3 mRNA

NCBI chr 6:109,413,617...109,419,840
Ensembl chr 6:109,413,534...109,421,427
Ensembl chr 6:109,413,534...109,421,427

G

acyl-CoA oxidase 1

increases expression

ISO

Sulfasalazine results in increased expression of ACOX1 mRNA

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136

G

actin alpha 2, smooth muscle

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

ADRM1 26S proteasome ubiquitin receptor

increases expression

EXP

Sulfasalazine results in increased expression of ADRM1 protein

NCBI chr 3:187,643,043...187,647,805
Ensembl chr 3:187,642,654...187,648,483

G

advanced glycosylation end product-specific receptor

multiple interactions

EXP

sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Ager protein] in rat colon

RGD

NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions
affects localization

ISO

BCL2 protein inhibits the reaction [Sulfasalazine affects the localization of AIFM1 protein]

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237

G

AKT serine/threonine kinase 1

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

aldehyde dehydrogenase 1 family, member A1

decreases expression
increases expression

ISO
EXP

Sulfasalazine results in decreased expression of ALDH1A1 mRNA
Sulfasalazine results in increased expression of ALDH1A1 protein

PMID:15928459 PMID:31830553

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:227,427,070...227,579,500

G

aldehyde dehydrogenase 2 family member

increases expression

EXP

Sulfasalazine results in increased expression of ALDH2 protein

NCBI chr12:40,610,244...40,643,220
Ensembl chr12:40,610,224...40,643,219

G

aldehyde dehydrogenase 6 family, member A1

decreases expression

EXP

Sulfasalazine results in decreased expression of ALDH6A1 protein

NCBI chr 6:109,809,092...109,829,725
Ensembl chr 6:109,809,122...109,829,743

G

alkaline phosphatase, intestinal

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of ALPI protein]

NCBI chr 9:95,221,314...95,224,780
Ensembl chr 9:95,221,314...95,224,780

G

annexin A2

increases expression

ISO

Sulfasalazine results in increased expression of ANXA2 mRNA

NCBI chr 8:78,986,252...79,022,638
Ensembl chr 8:78,986,242...79,022,631

G

apolipoprotein A4

decreases expression

ISO

Sulfasalazine results in decreased expression of APOA4 mRNA

NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:55,434,168...55,438,164

G

ATP synthase F1 subunit alpha

increases expression

EXP

Sulfasalazine results in increased expression of ATP5F1A protein

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922

G

antizyme inhibitor 1

increases expression

ISO

Sulfasalazine results in increased expression of AZIN1 mRNA

NCBI chr 7:71,539,711...71,566,515
Ensembl chr 7:71,539,711...71,566,515

G

BCL2 associated X, apoptosis regulator

affects localization
multiple interactions

ISO
EXP

Sulfasalazine affects the localization of BAX protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein]

PMID:12381674 PMID:31428839

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO
EXP

BCL2 protein inhibits the reaction [Sulfasalazine affects the localization of AIFM1 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of Bcl-2 protein] in rat colon

CTD
RGD

PMID:12381674 PMID:31428839 PMID:29572553

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

complement C6

decreases expression

ISO

Sulfasalazine results in decreased expression of C6 mRNA

NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:55,573,653...55,649,120

G

calreticulin

decreases expression

EXP

Sulfasalazine results in decreased expression of CALR protein

NCBI chr19:40,213,367...40,218,262
Ensembl chr19:40,213,239...40,219,236

G

caspase 1

multiple interactions

EXP
ISO

Sulfasalazine inhibits the reaction [Acetic Acid results in increased cleavage of CASP1 protein]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of CASP1 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 protein]

PMID:30408459 PMID:35595039 PMID:36577154

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 3

multiple interactions
increases activity

ISO
EXP

Sulfasalazine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]; Sulfasalazine results in increased cleavage of and results in increased activity of CASP3 protein
Sulfasalazine results in increased activity of CASP3 protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CASP3 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of CASP3 protein]

PMID:12381674 PMID:16322111 PMID:17051331 PMID:19473188 PMID:19859796 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions
increases cleavage

ISO

Sulfasalazine inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP9 protein]
Sulfasalazine results in increased cleavage of CASP9 protein

PMID:16322111 PMID:19859796

Ensembl chr 5:159,391,188...159,409,648

G

catalase

increases activity
multiple interactions
decreases activity

EXP
ISO

Sulfasalazine results in increased activity of CAT protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased activity of CAT protein]
Sulfasalazine results in decreased activity of CAT protein

PMID:19028562 PMID:19071188 PMID:28421826

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

caveolin 1

multiple interactions

ISO

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA

NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740

G

carbonyl reductase 1

decreases expression

EXP

Sulfasalazine results in decreased expression of CBR1 protein

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104

G

C-C motif chemokine ligand 2

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin D1

multiple interactions
decreases expression

ISO
EXP

[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA
Sulfasalazine results in decreased expression of CCND1 mRNA

PMID:17202759 PMID:19015640

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin G1

increases expression

ISO

Sulfasalazine results in increased expression of CCNG1 mRNA

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

CD14 molecule

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD14 mRNA

NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292

G

CD19 molecule

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD19 mRNA

NCBI chr 1:190,417,853...190,424,494
Ensembl chr 1:190,417,853...190,424,355

G

CD27 molecule

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD27 mRNA

NCBI chr 4:159,716,932...159,721,823
Ensembl chr 4:159,716,935...159,721,823

G

CD38 molecule

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD38 mRNA

NCBI chr14:71,384,532...71,424,794
Ensembl chr14:71,384,532...71,424,505

G

CD3 delta subunit of T-cell receptor complex

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD3D mRNA

NCBI chr 8:54,184,573...54,190,112
Ensembl chr 8:54,175,155...54,196,722

G

CD46 molecule

decreases expression

EXP

Sulfasalazine results in decreased expression of CD46 mRNA

NCBI chr13:109,104,122...109,134,903

G

CD55 molecule (Cromer blood group)

decreases expression

EXP

Sulfasalazine results in decreased expression of CD55 mRNA

PMID:15625186 PMID:17166698

NCBI chr13:44,409,574...44,438,913
Ensembl chr13:44,409,587...44,438,107

G

CD59b molecule

decreases expression

EXP

Sulfasalazine results in decreased expression of CD59 mRNA; Sulfasalazine results in decreased expression of CD59 protein

PMID:15625186 PMID:17166698

NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:110,914,091...110,935,310

G

CD74 molecule

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD74 mRNA

NCBI chr18:56,527,071...56,536,406
Ensembl chr18:56,527,132...56,536,410

G

cadherin 1

multiple interactions

ISO

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

EXP

protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein]

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

claudin 2

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN2 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN2 protein]

NCBI chr X:108,248,383...108,258,847
Ensembl chr X:108,237,676...108,262,377

G

clusterin

increases expression

ISO

Sulfasalazine results in increased expression of CLU mRNA

NCBI chr15:44,336,619...44,375,861
Ensembl chr15:44,359,914...44,375,860

G

collagen type I alpha 1 chain

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

colony stimulating factor 2

multiple interactions

ISO

Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CSF2 protein]

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,887,692...38,890,031

G

cytotoxic T-lymphocyte-associated protein 4

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CTLA4 mRNA

NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:69,813,265...69,819,973

G

catenin beta 1

multiple interactions

ISO
EXP

[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CTNNB1 protein]

PMID:19015640 PMID:26165751

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

C-X-C motif chemokine ligand 1

multiple interactions
affects secretion

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]

PMID:12231210 PMID:28863153

NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811

G

C-X-C motif chemokine ligand 3

affects secretion
multiple interactions

ISO

Sulfasalazine affects the secretion of CXCL1 protein
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]

PMID:12231210 PMID:28863153

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

EXP

Sulfasalazine results in increased expression of CYP1A1 mRNA

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 27, subfamily b, polypeptide 1

decreases expression

ISO

Sulfasalazine results in decreased expression of CYP27B1 mRNA

NCBI chr 7:64,756,626...64,761,570
Ensembl chr 7:64,756,626...64,761,570

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression

ISO

Sulfasalazine results in increased expression of CYP2B10 mRNA

NCBI chr 1:90,780,468...90,859,852

G

cytochrome P450, family 2, subfamily c, polypeptide 24

increases expression

ISO

Sulfasalazine results in increased expression of CYP2C55 mRNA; Sulfasalazine results in increased expression of CYP2C55 protein

NCBI chr 1:246,286,341...246,348,607
Ensembl chr 1:246,286,341...246,348,607

G

cytochrome P450, family 2, subfamily C, polypeptide 6

increases expression

ISO

Sulfasalazine results in increased expression of CYP2C29 mRNA

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

DNA-damage inducible transcript 3

increases expression

ISO

Sulfasalazine results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

iodothyronine deiodinase 1

multiple interactions

ISO

[Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA]

NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771

G

iodothyronine deiodinase 2

multiple interactions

ISO
EXP

Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]; Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]
Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of DIO2 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]

PMID:16728495 PMID:21068073

NCBI chr 6:115,396,308...115,410,594
Ensembl chr 6:115,396,308...115,410,594

G

DnaJ heat shock protein family (Hsp40) member A2

increases expression

ISO

Sulfasalazine results in increased expression of DNAJA2 mRNA

NCBI chr19:37,671,019...37,689,163
Ensembl chr19:37,670,945...37,690,120

G

epidermal growth factor

increases expression

ISO

Sulfasalazine results in increased expression of EGF mRNA

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions
decreases expression

ISO

[Sulfasalazine co-treated with celastrol] affects the expression of EGFR protein; [Sulfasalazine co-treated with celastrol] results in decreased expression of EGFR protein; geldanamycin promotes the reaction [Sulfasalazine results in decreased expression of EGFR protein]
Sulfasalazine results in decreased expression of EGFR mRNA; Sulfasalazine results in decreased expression of EGFR protein

PMID:20007406 PMID:31830553

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

decreases expression

ISO

Sulfasalazine results in decreased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

epoxide hydrolase 1

increases expression

ISO

Sulfasalazine results in increased expression of EPHX1 mRNA

PMID:22016648 PMID:31830553

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:95,246,080...95,321,981

G

coagulation factor III, tissue factor

multiple interactions

ISO

Sulfasalazine inhibits the reaction [Heme results in increased expression of F3 mRNA]

NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:212,511,680...212,523,369

G

fatty acid binding protein 4

increases expression

ISO

Sulfasalazine results in increased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

fibrinogen alpha chain

increases expression

ISO

Sulfasalazine results in increased expression of FGA mRNA

NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577

G

fumarate hydratase

decreases expression

EXP

Sulfasalazine results in decreased expression of FH protein

NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627

G

formation of mitochondrial complex V assembly factor 1

decreases expression

ISO

Sulfasalazine results in decreased expression of FMC1 mRNA

NCBI chr 4:68,241,009...68,249,045
Ensembl chr 4:68,241,009...68,268,534

G

follicle stimulating hormone subunit beta

multiple interactions

ISO

Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of FSHB protein]

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

ferritin light chain 1

increases expression

ISO

Sulfasalazine results in increased expression of FTL1 mRNA

NCBI chr 1:105,072,858...105,074,705
Ensembl chr X:45,399,355...45,399,915
Ensembl chr 2:45,399,355...45,399,915
Ensembl chr 1:45,399,355...45,399,915

G

G0/G1switch 2

increases expression

ISO

Sulfasalazine results in increased expression of G0S2 mRNA

NCBI chr13:107,335,036...107,335,948
Ensembl chr13:107,335,036...107,336,293

G

growth arrest and DNA-damage-inducible, beta

decreases expression

EXP

Sulfasalazine results in decreased expression of GADD45B mRNA

NCBI chr 7:9,428,689...9,430,991
Ensembl chr 7:9,428,689...9,430,718

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

EXP

Sulfasalazine results in decreased expression of GAPDH protein

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377

G

glial cell derived neurotrophic factor

multiple interactions

ISO

Sulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein]

NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:58,621,327...58,647,240

G

glutamic--pyruvic transaminase

increases expression

ISO

Sulfasalazine results in increased expression of GPT protein

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 3

decreases expression

ISO

Sulfasalazine results in decreased expression of GPX3 mRNA

NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405

G

glycogen synthase kinase 3 beta

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of GSK3B protein]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

glutathione-disulfide reductase

decreases activity

EXP

Sulfasalazine results in decreased activity of GSR protein

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase alpha 2

increases expression

ISO

Sulfasalazine results in increased expression of GSTA1 mRNA

NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:88,064,616...88,077,092

G

glutathione S-transferase alpha 5

increases expression

EXP

Sulfasalazine results in increased expression of GSTA5 mRNA

NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765

G

glutathione S-transferase mu 1

decreases expression

EXP

Sulfasalazine results in decreased expression of GSTM1 protein

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

glutathione S-transferase mu 2

increases expression

ISO

Sulfasalazine results in increased expression of GSTM2 mRNA

NCBI chr 2:198,312,179...198,316,962

G

glutathione S-transferase, mu 5

increases expression

ISO

Sulfasalazine results in increased expression of GSTM3 mRNA

NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731

G

glutathione S-transferase pi 1

decreases expression

EXP

Sulfasalazine results in decreased expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

hepatocyte growth factor

multiple interactions

ISO

Sulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA]

NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:19,632,267...19,700,851

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases activity

ISO

Sulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]
Sulfasalazine results in increased activity of HIF1A protein

PMID:12808024 PMID:19502547

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

histidine triad nucleotide binding protein 1

increases expression

ISO

Sulfasalazine results in increased expression of HINT1 mRNA

NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:93,430,926...93,431,642
Ensembl chr10:93,430,926...93,431,642

G

high mobility group box 1

increases expression
multiple interactions

EXP

Sulfasalazine results in increased expression of HMGB1 mRNA
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Hmgb1 protein] in rat colon

CTD
RGD

PMID:16141653 PMID:29572553

NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327

G

heme oxygenase 1

increases response to substance
multiple interactions
increases expression

EXP

HMOX1 protein results in increased susceptibility to Sulfasalazine
NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 protein]; protoporphyrin IX inhibits the reaction [[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein]; Sulfasalazine promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]
[Sulfasalazine results in increased expression of HMOX1 protein] which results in increased expression of CDKN1A protein; Sulfasalazine results in increased expression of HMOX1 mRNA; Sulfasalazine results in increased expression of HMOX1 protein

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hydroxysteroid (17-beta) dehydrogenase 3

decreases expression

EXP

Sulfasalazine results in decreased expression of HSD17B3 mRNA

NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283

G

hydroxysteroid (17-beta) dehydrogenase 4

increases expression

ISO

Sulfasalazine results in increased expression of HSD17B4 mRNA

NCBI chr18:45,515,427...45,604,467
Ensembl chr18:45,515,373...45,604,467

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression

EXP

Sulfasalazine results in decreased expression of HSD3B1 mRNA

NCBI chr 2:188,858,574...188,864,694

G

heat shock protein 90 alpha family class B member 1

increases expression

ISO

Sulfasalazine results in increased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926

G

heat shock protein family A (Hsp70) member 1A

increases expression

ISO

Sulfasalazine results in increased expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 1B

decreases expression

EXP

Sulfasalazine results in decreased expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,855,780...3,877,979

G

heat shock protein family A (Hsp70) member 2

decreases expression

EXP

Sulfasalazine results in decreased expression of HSPA2 protein

NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:100,864,553...100,867,133

G

intercellular adhesion molecule 1

decreases expression
increases expression
multiple interactions

ISO
EXP

Sulfasalazine results in decreased expression of ICAM1 mRNA; Sulfasalazine results in decreased expression of ICAM1 protein
Sulfasalazine results in increased expression of ICAM1 protein
Sulfasalazine inhibits the reaction [RELA protein binds to ICAM1 promoter]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Icam-1 protein] in rat colon

CTD
RGD

PMID:11264155 PMID:15553846 PMID:17259377 PMID:20823682 PMID:26165751 More...

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta

increases expression

ISO

Sulfasalazine results in increased expression of IDH3B mRNA

NCBI chr 3:137,934,971...137,940,275
Ensembl chr 3:137,934,697...137,940,107

G

indoleamine 2,3-dioxygenase 1

multiple interactions

ISO

Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IDO1 mRNA]

NCBI chr16:74,133,259...74,145,328
Ensembl chr16:74,133,259...74,145,328

G

interferon gamma

multiple interactions

ISO

[Sulfasalazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IFNG protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [IFNG protein results in increased expression of CXCL8 protein]
Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IFNG protein]

PMID:11529938 PMID:15269287 PMID:17051331 PMID:25231984 PMID:29594315 More...

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

insulin-like growth factor binding protein 3

affects expression

EXP

Sulfasalazine affects the expression of IGFBP3 mRNA

NCBI chr14:86,270,208...86,277,944
Ensembl chr14:86,270,208...86,277,944

G

inhibitor of nuclear factor kappa B kinase subunit beta

decreases expression

ISO

Sulfasalazine results in decreased expression of IKBKB protein

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 10

multiple interactions

ISO
EXP

Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL10 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]; Sulfasalazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL10 protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein] in rat colon

CTD
RGD

PMID:15604057 PMID:17051331 PMID:25231984 PMID:25727887 PMID:29731490 More...

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 10 receptor subunit alpha

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IL10RA mRNA

NCBI chr 8:54,459,754...54,474,786
Ensembl chr 8:54,459,882...54,475,028

G

interleukin 12A

multiple interactions

ISO

Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]

NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997

G

interleukin 12B

multiple interactions

ISO

Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of [IL12B protein binds to IL12A protein]]; Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein]

NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194

G

interleukin 17A

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL17A protein]

NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331

G

interleukin 18

multiple interactions

EXP
ISO

Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of IL18 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL18 protein]

PMID:35595039 PMID:36577154 PMID:38764152

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 beta

multiple interactions
decreases expression

ISO
EXP

[Sulfasalazine co-treated with pyrazolanthrone] inhibits the reaction [IL1B protein results in decreased expression of DIO1 mRNA]; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL1 protein]; IL1B protein affects the reaction [Sulfasalazine affects the secretion of CXCL8 protein]; Sulfasalazine inhibits the reaction [IL1B protein results in decreased expression of THRB mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of IL1B protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA]
Sulfasalazine results in decreased expression of IL1B mRNA
[allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]

PMID:12133438 PMID:12231210 PMID:15604057 PMID:15793857 PMID:15867298 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor type 1

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1R1 mRNA]

NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579

G

interleukin 1 receptor antagonist

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1RN mRNA]

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732

G

interleukin 2

multiple interactions

ISO

[Sulfasalazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL2 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of IL2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL2 protein]

PMID:17051331 PMID:29594315 PMID:32272095 PMID:35362542

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 2 receptor subunit alpha

multiple interactions

ISO

Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2RA protein]

NCBI chr17:71,759,802...71,808,475
Ensembl chr17:71,759,802...71,808,507

G

interleukin 4

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased secretion of IL4 protein]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions

ISO
EXP

Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of IL6 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]

PMID:12135912 PMID:17051331 PMID:19956958 PMID:20884048 PMID:21070844 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin receptor

increases expression

ISO

Sulfasalazine results in increased expression of INSR protein

NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803

G

interferon regulatory factor 4

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IRF4 mRNA

NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,930,471...33,948,730

G

insulin receptor substrate 2

decreases expression

ISO

Sulfasalazine results in decreased expression of IRS2 mRNA

NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543

G

integrin subunit alpha M

multiple interactions

ISO

Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGAM protein]

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

integrin subunit beta 2

multiple interactions

ISO

Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein]

NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182

G

IL2-inducible T-cell kinase

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of ITK mRNA

NCBI chr10:31,254,667...31,316,004
Ensembl chr10:31,254,667...31,316,004

G

Janus kinase 2

multiple interactions

ISO

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of JAK2 protein]

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

joining chain of multimeric IgA and IgM

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of JCHAIN mRNA

NCBI chr14:19,822,976...19,831,072
Ensembl chr14:19,822,976...19,838,307

G

LCK proto-oncogene, Src family tyrosine kinase

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of LCK mRNA

NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267

G

lactate dehydrogenase C

multiple interactions
increases activity

ISO

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of LDHC protein]
Sulfasalazine results in increased activity of LDHC protein

NCBI chr 1:106,522,140...106,539,649
Ensembl chr 1:106,522,236...106,542,802

G

luteinizing hormone subunit beta

multiple interactions

ISO

Sulfasalazine inhibits the reaction [Dextran Sulfate results in decreased expression of LHB protein]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

LSM10, U7 small nuclear RNA associated

decreases expression

ISO

Sulfasalazine results in decreased expression of LSM10 mRNA

NCBI chr 5:143,649,817...143,660,391
Ensembl chr 5:143,615,360...143,663,986

G

mitogen activated protein kinase 1

multiple interactions

EXP
ISO

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK1 protein]

PMID:36806191 PMID:38764152

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

EXP
ISO

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of MAPK3 protein]

PMID:36806191 PMID:38764152

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 9

increases phosphorylation

EXP

Sulfasalazine results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

MHC I like leukocyte 1

decreases expression

ISO

Sulfasalazine results in decreased expression of MICA mRNA; Sulfasalazine results in decreased expression of MICA protein

NCBI chr 1:87,500,591...87,526,983
Ensembl chr 1:87,500,676...87,526,981

G

microRNA 223

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Acetic Acid results in decreased expression of MIR223 mRNA]

NCBI chr X:65,151,383...65,151,492
Ensembl chr X:65,151,383...65,151,492

G

matrix metallopeptidase 1

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MMP1 mRNA

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:12,943,453...12,963,964

G

matrix metallopeptidase 2

multiple interactions

EXP

Sulfasalazine promotes the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

multiple interactions

ISO
EXP

Sulfasalazine inhibits the reaction [HGF protein results in increased expression of MMP9 mRNA]; Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of and results in increased cleavage of MMP9 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of MMP9 protein]

PMID:12745093 PMID:22119283 PMID:30972795

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

multiple interactions
decreases activity

EXP
ISO

Sulfasalazine inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Dinitrochlorobenzene results in decreased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MPO protein]
Sulfasalazine results in decreased activity of MPO protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of MPO protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases myeloperoxidase enzyme activity] in rat colon

CTD
RGD

PMID:17373747 PMID:20380826 PMID:22119283 PMID:23665423 PMID:25231984 More...

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

major histocompatibility complex, class I-related

affects expression

ISO

Sulfasalazine affects the expression of MR1 mRNA

NCBI chr13:69,850,420...69,868,302
Ensembl chr13:69,850,420...69,868,502

G

membrane spanning 4-domains A1

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MS4A1 mRNA

NCBI chr 1:217,331,274...217,351,934
Ensembl chr 1:217,331,274...217,343,447

G

methylenetetrahydrofolate reductase

increases response to substance

ISO

MTHFR gene polymorphism results in increased susceptibility to Sulfasalazine; MTHFR protein results in increased susceptibility to Sulfasalazine

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105

G

mucin 17, cell surface associated

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC17 mRNA]

NCBI chr12:25,139,076...25,175,249

G

mucin 2, oligomeric mucus/gel-forming

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC2 mRNA]

NCBI chr 1:206,225,775...206,261,280
Ensembl chr 1:206,229,035...206,261,280

G

mucin 4, cell surface associated

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MUC4 mRNA]

NCBI chr11:81,513,321...81,575,200

G

MYD88, innate immune signal transduction adaptor

multiple interactions

EXP
ISO

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of MYD88 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of MYD88 protein]

PMID:35290143 PMID:35362542

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230

G

N-acetyltransferase 2

affects metabolic processing
affects response to substance
increases metabolic processing
increases acetylation

ISO

NAT2 gene polymorphism affects the metabolism of Sulfasalazine; NAT2 protein affects the metabolism of Sulfasalazine; NAT2 protein polymorphism affects the metabolism of Sulfasalazine
NAT2 protein affects the susceptibility to Sulfasalazine
NAT2 protein results in increased metabolism of Sulfasalazine
NAT2 protein results in increased acetylation of Sulfasalazine

PMID:12465141 PMID:15032315 PMID:17377643 PMID:17502830 PMID:19560446

NCBI chr16:26,974,874...27,005,191
Ensembl chr16:26,974,601...26,976,304

G

nucleolin

decreases expression

EXP

Sulfasalazine results in decreased expression of NCL protein

NCBI chr 9:94,447,559...94,456,083
Ensembl chr 9:94,446,682...94,456,083

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO
EXP

[Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein; Acetylcysteine inhibits the reaction [[Sulfasalazine results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased localization of NFE2L2 protein]
NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [Sulfasalazine results in increased expression of HMOX1 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of NFE2L2 mRNA]; Sulfasalazine promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]

PMID:19234301 PMID:31428839

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions
decreases expression
decreases localization

ISO
EXP

Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]
Sulfasalazine results in decreased expression of NFKB1 protein
Sulfasalazine results in decreased localization of NFKB1 protein
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NFKB1 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKB1 protein]

PMID:9486988 PMID:12135912 PMID:15269287 PMID:17259377 PMID:26165751 More...

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

multiple interactions
decreases expression
decreases phosphorylation
increases degradation

ISO
EXP

Sulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Sulfasalazine results in decreased expression of NFKBIA protein
Sulfasalazine results in decreased phosphorylation of NFKBIA protein
Sulfasalazine results in increased degradation of NFKBIA protein
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Glucose results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased degradation of NFKBIA protein]

PMID:9486988 PMID:11786414 PMID:15494508 PMID:15793857 PMID:16934226 More...

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NLR family, pyrin domain containing 3

multiple interactions

EXP
ISO

Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of NLRP3 mRNA]; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of NLRP3 protein]
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 protein]

PMID:30408459 PMID:35595039 PMID:36577154

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

nitric oxide synthase 2

multiple interactions
decreases expression

ISO
EXP

Sulfasalazine inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
Sulfasalazine affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]
Sulfasalazine results in decreased expression of NOS2 mRNA

PMID:11529938 PMID:15867298 PMID:16925772 PMID:16934226 PMID:17259377 More...

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

increases expression

EXP
ISO

Sulfasalazine results in increased expression of NQO1 mRNA

PMID:19234301 PMID:22016648

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 3, group C, member 1

increases expression

ISO

Sulfasalazine results in increased expression of NR3C1 mRNA; Sulfasalazine results in increased expression of NR3C1 protein

NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843

G

NSFL1 cofactor

increases expression

EXP

Sulfasalazine results in increased expression of NSFL1C protein

NCBI chr 3:160,438,708...160,463,261
Ensembl chr 3:160,438,708...160,463,228

G

ornithine aminotransferase

increases expression

ISO

Sulfasalazine results in increased expression of OAT mRNA

NCBI chr 1:196,777,973...196,797,754
Ensembl chr 1:196,777,975...196,797,754

G

occludin

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN protein]

NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:33,391,303...33,430,411

G

ornithine decarboxylase 1

increases expression

ISO

Sulfasalazine results in increased expression of ODC1 mRNA

NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:46,058,463...46,065,146

G

opioid receptor, mu 1

multiple interactions

ISO

Sulfasalazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of OPRM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA]

NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756

G

proliferating cell nuclear antigen

increases expression

ISO

Sulfasalazine results in increased expression of PCNA mRNA

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

phosphatidylethanolamine binding protein 1

decreases expression

EXP

Sulfasalazine results in decreased expression of PEBP1 protein

NCBI chr12:44,946,307...44,967,890
Ensembl chr12:44,963,675...44,971,780

G

phosphoglycerate mutase 2

increases expression

ISO

Sulfasalazine results in increased expression of PGAM2 mRNA

NCBI chr14:84,895,763...84,897,874
Ensembl chr14:84,895,744...84,897,894

G

phospholipase A2 group IB

multiple interactions

ISO

Sulfasalazine inhibits the reaction [PLA2G1B protein results in increased expression of CXCL8 protein]

NCBI chr12:46,802,932...46,814,511
Ensembl chr12:46,802,939...46,813,693

G

peroxisome proliferator-activated receptor gamma

increases expression
multiple interactions

EXP
ISO

Sulfasalazine results in increased expression of PPARG mRNA
Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG protein]

PMID:19365232 PMID:26165751 PMID:31830553

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PR/SET domain 1

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of PRDM1 mRNA

NCBI chr20:49,542,465...49,564,088
Ensembl chr20:49,542,465...49,564,088

G

peroxiredoxin 1

increases expression

EXP
ISO

Sulfasalazine results in increased expression of PRDX1 mRNA

PMID:16141653 PMID:22016648

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

peroxiredoxin 3

increases expression

ISO

Sulfasalazine results in increased expression of PRDX3 mRNA

NCBI chr 1:269,987,691...270,000,111
Ensembl chr 1:269,987,685...270,000,300

G

proteasome 20S subunit alpha 7

decreases expression

EXP

Sulfasalazine results in decreased expression of PSMA7 protein

NCBI chr 3:187,514,901...187,521,289
Ensembl chr 3:187,513,441...187,521,253

G

proteasome 20S subunit beta 9

decreases expression

EXP

Sulfasalazine results in decreased expression of PSMB9 mRNA

NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,668,739...4,674,421

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions

EXP
ISO

Sulfasalazine results in decreased expression of PTGS2 mRNA
Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein]

PMID:17259377 PMID:19956958 PMID:25576893 PMID:29187079 PMID:30408459 More...

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine phosphatase, mitochondrial 1

increases expression

ISO

Sulfasalazine results in increased expression of PTPMT1 mRNA

NCBI chr 3:97,345,752...97,355,396
Ensembl chr 3:97,345,752...97,355,254

G

RAS guanyl releasing protein 1

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of RASGRP1 mRNA

NCBI chr 3:124,624,039...124,684,079
Ensembl chr 3:124,622,313...124,684,434

G

retinol binding protein 4

affects expression

ISO

Sulfasalazine affects the expression of RBP4 mRNA

NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:245,306,349...245,313,898

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases activity
increases localization
affects localization
decreases localization

ISO
EXP

Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [rasagiline results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [RELA protein promotes the reaction [Lipopolysaccharides results in increased expression of DIO2 mRNA]]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine results in decreased expression of and results in decreased activity of RELA protein; Sulfasalazine results in decreased phosphorylation of and results in decreased activity of RELA protein
Sulfasalazine results in decreased activity of RELA protein
Sulfasalazine results in increased localization of RELA protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [RELA protein binds to ICAM1 promoter]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
Sulfasalazine affects the localization of RELA protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased phosphorylation of RELA protein]; Sulfasalazine inhibits the reaction [Gentamicins results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of RELA protein]
Sulfasalazine results in decreased localization of RELA protein
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Nf-Kb protein] in rat colon

CTD
RGD

PMID:9486988 PMID:12135912 PMID:14687604 PMID:15269287 PMID:15564333 More...

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

regulator of G-protein signaling 16

increases expression

ISO

Sulfasalazine results in increased expression of RGS16 mRNA

NCBI chr13:68,421,480...68,443,312
Ensembl chr13:68,438,120...68,443,313

G

receptor-interacting serine-threonine kinase 2

multiple interactions

ISO

Sulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA]

NCBI chr 5:34,428,573...34,459,808
Ensembl chr 5:34,428,573...34,459,663

G

ring finger protein 186

decreases expression

ISO

Sulfasalazine results in decreased expression of RNF186 mRNA

NCBI chr 5:156,493,750...156,494,974
Ensembl chr 5:156,493,752...156,494,978

G

RT1 class II, locus Bb

affects expression

EXP

Sulfasalazine affects the expression of RT1-BB mRNA

NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,598,475...4,604,118

G

S100 calcium binding protein A9

multiple interactions

ISO

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of S100A9 protein]

NCBI chr 2:178,487,941...178,490,622
Ensembl chr 2:178,487,941...178,490,870

G

syndecan 1

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SDC1 mRNA

NCBI chr 6:37,282,041...37,304,503
Ensembl chr 6:37,297,010...37,304,500

G

selectin E

increases expression

ISO

Sulfasalazine results in increased expression of SELE protein

NCBI chr13:78,935,997...78,945,905
Ensembl chr13:78,936,036...78,945,903

G

serpin family A member 4

decreases expression

ISO

Sulfasalazine results in decreased expression of SERPINA4-PS1 mRNA

NCBI chr 6:128,764,738...128,773,858
Ensembl chr 6:128,764,769...128,776,028

G

serpin family C member 1

increases expression

ISO

Sulfasalazine results in increased expression of SERPINC1 mRNA

NCBI chr13:75,790,558...75,804,826
Ensembl chr13:75,790,546...75,817,643

G

salt-inducible kinase 1

decreases expression

ISO

Sulfasalazine results in decreased expression of SIK1 mRNA

NCBI chr20:9,947,104...9,958,729
Ensembl chr20:9,947,105...9,958,698

G

SLAM family member 7

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SLAMF7 mRNA

NCBI chr13:86,668,060...86,688,222
Ensembl chr13:86,668,060...86,686,341

G

solute carrier family 22 member 7

decreases expression

ISO

Sulfasalazine results in decreased expression of SLC22A7 mRNA

NCBI chr 9:22,044,672...22,052,051
Ensembl chr 9:22,045,435...22,051,681

G

solute carrier family 25 member 24

decreases expression

ISO

Sulfasalazine results in decreased expression of SLC25A24 mRNA

NCBI chr 2:199,449,425...199,487,287
Ensembl chr 2:199,449,345...199,487,290

G

solute carrier family 25 member 5

increases expression

ISO

Sulfasalazine results in increased expression of SLC25A6 mRNA

NCBI chr X:120,897,616...120,900,683
Ensembl chr X:120,897,563...120,900,688

G

solute carrier family 30 member 1

decreases expression

ISO

Sulfasalazine results in decreased expression of SLC30A1 mRNA

NCBI chr13:106,022,019...106,025,892
Ensembl chr13:106,022,019...106,025,892

G

solute carrier family 3 member 2

multiple interactions

ISO

Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:215,033,601...215,048,064

G

solute carrier family 46 member 1

multiple interactions
decreases activity

ISO
EXP

Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Methotrexate]
Sulfasalazine inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
Sulfasalazine results in decreased activity of SLC46A1 protein

PMID:17475902 PMID:18174275 PMID:19762432

NCBI chr10:63,859,551...63,865,987
Ensembl chr10:63,859,504...63,866,869

G

solute carrier family 7 member 11

decreases activity
multiple interactions

ISO

Sulfasalazine results in decreased activity of SLC7A11 protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA]; [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species; [[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein] which results in decreased expression of CCND1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased localization of and results in decreased activity of CTNNB1 protein; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CAV1 mRNA; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in increased expression of CDH1 mRNA; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]

PMID:19015640 PMID:19576933 PMID:20007406

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

suppressor of cytokine signaling 2

decreases expression

ISO

Sulfasalazine results in decreased expression of SOCS2 mRNA

NCBI chr 7:31,890,564...31,932,092
Ensembl chr 7:31,874,463...31,930,423

G

suppressor of cytokine signaling 3

multiple interactions

EXP

sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Socs3 protein] in rat colon

RGD

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825

G

superoxide dismutase 1

increases expression

ISO

Sulfasalazine results in increased expression of SOD1 mRNA

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 3

decreases expression

ISO

Sulfasalazine results in decreased expression of SOD3 mRNA

NCBI chr14:62,822,865...62,828,602
Ensembl chr14:62,811,177...62,829,125

G

secreted phosphoprotein 1

increases expression

ISO

Sulfasalazine results in increased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

serine and arginine rich splicing factor 5

increases expression

EXP

Sulfasalazine results in increased expression of SRSF5 protein

NCBI chr 6:106,333,998...106,341,467
Ensembl chr 6:106,336,756...106,341,931

G

steroidogenic acute regulatory protein

decreases expression
affects expression

EXP

Sulfasalazine results in decreased expression of STAR protein
Sulfasalazine affects the expression of STAR mRNA

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

signal transducer and activator of transcription 3

multiple interactions

ISO

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased phosphorylation of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

thromboxane A synthase 1

multiple interactions
decreases activity

ISO

[Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of 12-hydroxy-5,8,10-heptadecatrienoic acid; [Sulfasalazine results in decreased activity of TBXAS1 protein] which results in decreased chemical synthesis of Thromboxane B2

NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:68,631,838...68,803,969

G

tryptophan 2,3-dioxygenase

multiple interactions

ISO

Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TDO2 mRNA]

NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:169,567,654...169,585,586

G

trefoil factor 3

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TFF3 mRNA]

NCBI chr20:9,194,623...9,199,333
Ensembl chr20:9,194,626...9,199,333

G

thyroid hormone receptor alpha

multiple interactions
decreases expression

ISO

[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA; IL1B protein inhibits the reaction [[Sulfasalazine co-treated with pyrazolanthrone] results in decreased expression of THRA mRNA]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA alternative form]; Sulfasalazine promotes the reaction [IL1B protein results in decreased expression of THRA mRNA]
Sulfasalazine results in decreased expression of THRA mRNA; Sulfasalazine results in decreased expression of THRA mRNA alternative form

NCBI chr10:84,198,141...84,225,659
Ensembl chr10:84,197,011...84,225,657

G

thyroid hormone receptor beta

multiple interactions

ISO

Sulfasalazine inhibits the reaction [IL1B protein results in decreased expression of THRB mRNA]

NCBI chr15:10,115,954...10,465,231
Ensembl chr15:10,115,954...10,313,680

G

TIMP metallopeptidase inhibitor 1

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

TIMP metallopeptidase inhibitor 2

increases expression

ISO

Sulfasalazine results in increased expression of TIMP2 mRNA

NCBI chr10:104,041,604...104,089,214
Ensembl chr10:104,041,604...104,089,214

G

TIMP metallopeptidase inhibitor 3

increases expression

ISO

Sulfasalazine results in increased expression of TIMP3 mRNA

NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547

G

tight junction protein 1

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 protein]

NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:128,260,330...128,505,158

G

toll-like receptor 2

multiple interactions

ISO

Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194

G

toll-like receptor 4

multiple interactions

ISO

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TLR4 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR4 protein]

PMID:19956958 PMID:32272095 PMID:35362542

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

toll-like receptor 9

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TLR9 protein]

NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:115,742,889...115,750,148

G

tumor necrosis factor

multiple interactions
increases response to substance
decreases expression
decreases secretion

ISO
EXP

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNF mRNA; Sulfasalazine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of HIF1A protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGAM protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of ITGB2 protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of NFKBIA mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of OPRM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of RIPK2 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Sulfasalazine inhibits the reaction [TNF protein results in increased localization of and results in increased activity of RELA protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Sulfasalazine promotes the reaction [Ganciclovir results in increased secretion of TNF protein]
Sulfasalazine results in increased susceptibility to TNF protein
[allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Sulfasalazine binds to and results in decreased activity of TNF protein; Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased secretion of TNF protein]
Sulfasalazine results in decreased expression of TNF mRNA
Sulfasalazine results in decreased secretion of TNF protein
Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of and results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased secretion of TNF protein]; Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
sulfasalazine inhibits the reaction [2,4,6-trinitrobenzenesulfonic acid increases abundance of Tnfa protein] in rat colon

CTD
RGD

PMID:8094364 PMID:8598465 PMID:9486988 PMID:11901219 PMID:12135912 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 11B

increases secretion

ISO

Sulfasalazine results in increased secretion of TNFRSF11B protein

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF receptor superfamily member 17

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNFRSF17 mRNA

NCBI chr10:4,808,023...4,813,857

G

TNF receptor superfamily member 1A

multiple interactions

EXP

Sulfasalazine inhibits the reaction [Acetic Acid results in increased expression of TNFRSF1A protein]

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF superfamily member 11

decreases expression

ISO

Sulfasalazine results in decreased expression of TNFSF11 mRNA; Sulfasalazine results in decreased expression of TNFSF11 protein

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

tropomyosin 3

decreases expression

ISO

Sulfasalazine results in decreased expression of TPM3 mRNA alternative form; Sulfasalazine results in decreased expression of TPM3 protein alternative form

NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:177,814,883...177,842,660

G

TNF receptor associated factor 6

multiple interactions

ISO

Sulfasalazine inhibits the reaction [Dextran Sulfate results in increased expression of TRAF6 protein]

NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328

G

thyroid stimulating hormone subunit beta

increases secretion

ISO

Sulfasalazine results in increased secretion of TSHB protein

NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:192,913,171...192,942,984

G

tubulin, beta 5 class I

increases expression

ISO

Sulfasalazine results in increased expression of TUBB5 mRNA

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726

G

thymidine phosphorylase

multiple interactions
decreases expression

ISO

Sulfasalazine inhibits the reaction [IFNG protein results in increased activity of TYMP protein]; Sulfasalazine inhibits the reaction [TNF protein results in increased activity of TYMP protein]; Sulfasalazine results in decreased expression of and results in decreased activity of TYMP protein
Sulfasalazine results in decreased expression of TYMP mRNA

NCBI chr 7:122,318,396...122,323,716
Ensembl chr 7:122,316,520...122,324,003

G

ubiquitin C

increases expression

ISO

Sulfasalazine results in increased expression of UBC mRNA

NCBI chr12:36,899,673...36,905,275
Ensembl chr12:36,900,127...36,905,275

G

vascular cell adhesion molecule 1

multiple interactions
decreases expression
increases expression

ISO
EXP

Sulfasalazine inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
Sulfasalazine results in decreased expression of VCAM1 mRNA; Sulfasalazine results in decreased expression of VCAM1 protein
Sulfasalazine results in increased expression of VCAM1 protein

PMID:11264155 PMID:15553846 PMID:17259377 PMID:19693652

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

vimentin

increases expression

ISO

Sulfasalazine results in increased expression of VIM mRNA

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746

G

X-box binding protein 1

multiple interactions

ISO

[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
chemical entity	20872
group	20774
inorganic group	20110
azo group	306
azo compound +	306
Path 2
Term	Annotations
CHEBI ontology	20874
subatomic particle	20883
composite particle	20883
hadron	20872
baryon	20883
nucleon	20872
atomic nucleus	20883
atom	20872
group	20774
inorganic group	20110
azo group	306
azo compound +	306

paths to the root