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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:acetate
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Accession:CHEBI:30089 term browser browse the term
Definition:A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid.
Synonyms:related_synonym: ACETATE ION;   Azetat;   CH3-COO(-);   Ethanoat;   Formula=C2H3O2;   InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)/p-1;   InChIKey=QTBSBXVTEAMEQO-UHFFFAOYSA-M;   MeCO2 anion;   SMILES=CC([O-])=O;   acetic acid, ion(1-);   ethanoate
 alt_id: CHEBI:13704;   CHEBI:22165;   CHEBI:40480
 xref: Beilstein:1901470;   CAS:71-50-1;   DrugBank:DB03166;   Gmelin:1379;   KEGG:C00033;   MetaCyc:ACET;   PDBeChem:ACT;   PMID:17190852;   PMID:22211106;   PMID:22371380;   Reaxys:1901470;   UM-BBD_compID:c0050;   Wikipedia:Acetate
 cyclic_relationship: is_conjugate_base_of CHEBI:15366


show annotations for term's descendants           Sort by:
acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor increases secretion EXP Acetate increases secretion of Tnf protein from Kupffer cells RGD PMID:19299582 RGD:9585771 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
GGTI-2133 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP GGTI-2133 inhibits the reaction [Smoke analog results in increased phosphorylation of AKT1 protein] CTD PMID:19299917 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP GGTI-2133 inhibits the reaction [Smoke analog results in increased phosphorylation of MAPK1 protein] CTD PMID:19299917 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP GGTI-2133 inhibits the reaction [Smoke analog results in increased phosphorylation of MAPK3 protein] CTD PMID:19299917 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP GGTI-2133 inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]; GGTI-2133 inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein] CTD PMID:19299917 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family decreases geranoylation ISO GGTI-2133 results in decreased geranoylation of RAP1A protein CTD PMID:25578243 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501 		JBrowse link
lead tetraacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein decreases expression ISO lead tetraacetate results in decreased expression of APP mRNA CTD PMID:20865013 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO lead tetraacetate results in decreased expression of MAPT mRNA CTD PMID:20865013 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Nrxn1 neurexin 1 decreases expression ISO lead tetraacetate results in decreased expression of NRXN1 mRNA CTD PMID:20865013 NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710 		JBrowse link
G Prnp prion protein decreases expression ISO lead tetraacetate results in decreased expression of PRNP mRNA CTD PMID:20865013 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Syp synaptophysin decreases expression ISO lead tetraacetate results in decreased expression of SYP mRNA CTD PMID:20865013 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tubb3 tubulin, beta 3 class III decreases expression ISO lead tetraacetate results in decreased expression of TUBB3 mRNA CTD PMID:20865013 NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243 		JBrowse link
sodium acetate trihydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acox1 acyl-CoA oxidase 1 increases expression ISO Sodium Acetate results in increased expression of ACOX1 mRNA CTD PMID:36156098 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 increases expression ISO Sodium Acetate results in increased expression of ACSS1 mRNA CTD PMID:36156098 NCBI chr 3:139,450,383...139,500,325
Ensembl chr 3:139,450,383...139,500,325 		JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 increases expression ISO Sodium Acetate results in increased expression of ACSS2 mRNA CTD PMID:36156098 NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675 		JBrowse link
G Ada adenosine deaminase multiple interactions EXP Sodium Acetate inhibits the reaction [Nicotine results in increased activity of ADA protein] CTD PMID:31857090 NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088 		JBrowse link
G Apob apolipoprotein B multiple interactions ISO [Sodium Acetate co-treated with acetic anhydride] results in increased acetylation of APOB protein CTD PMID:11304478 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 Sodium Acetate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] CTD PMID:36372261 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO Sodium Acetate inhibits the reaction [Cisplatin results in increased cleavage of CASP7 protein] CTD PMID:36372261 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 Sodium Acetate inhibits the reaction [Cisplatin results in decreased expression of CAT protein] CTD PMID:36372261 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO Sodium Acetate promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1A1 mRNA]; Sodium Acetate promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]		 CTD PMID:31621310 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO Sodium Acetate promotes the reaction [biochanin A results in increased expression of CYP1B1 mRNA]; Sodium Acetate promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA] CTD PMID:31621310 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP Sodium Acetate inhibits the reaction [Nicotine results in increased activity of GGT1 protein] CTD PMID:31857090 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of IFNG mRNA] CTD PMID:37269894 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of IKBKB mRNA]; [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of IKBKB protein] CTD PMID:37269894 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO Sodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of IL2 protein] CTD PMID:17615583 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of IL6 mRNA] CTD PMID:37269894 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Sodium Acetate inhibits the reaction [Nicotine results in increased expression of INS1 protein] CTD PMID:31857090 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Kpnb1 karyopherin subunit beta 1 multiple interactions ISO Sodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [NFATC2 protein binds to KPNB1 protein]] CTD PMID:17615583 NCBI chr10:82,145,662...82,174,437
Ensembl chr10:82,145,420...82,174,605 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of MYD88 mRNA] CTD PMID:37269894 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nat2 N-acetyltransferase 2 increases expression ISO Sodium Acetate results in increased expression of NAT2 mRNA CTD PMID:36156098 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 multiple interactions ISO Sodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of NFATC2 protein]; Sodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] promotes the reaction [NFATC2 protein binds to KPNB1 protein]]; Sodium Acetate inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of NFATC2 protein] CTD PMID:17615583 NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in decreased expression of NFKBIA protein] CTD PMID:37269894 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Sodium Acetate results in increased expression of PCK1 mRNA CTD PMID:36156098 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of and results in increased phosphorylation of RELA protein]; [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of RELA mRNA] CTD PMID:37269894 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO
EXP		 Sodium Acetate inhibits the reaction [Cisplatin results in decreased expression of SOD2 protein] CTD PMID:36372261 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TGFB1 mRNA] CTD PMID:37269894 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TLR2 mRNA]; [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TLR2 protein] CTD PMID:37269894 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TLR4 mRNA]; [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TLR4 protein] CTD PMID:37269894 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Sodium Acetate co-treated with Butyric Acid co-treated with sodium propionate] inhibits the reaction [Fluorides results in increased expression of TNF mRNA] CTD PMID:37269894 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO Sodium Acetate promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA] CTD PMID:31621310 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP Sodium Acetate inhibits the reaction [Nicotine results in increased activity of XDH protein] CTD PMID:31857090 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    chemical entity 19920
      molecular entity 19920
        ion 17101
          anion 16649
            organic anion 6850
              carboxylic acid anion 2500
                monocarboxylic acid anion 1604
                  acetate 41
                    (2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl)acetate + 0
                    (2,6-dihydroxyphenyl)acetate 0
                    (5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate 0
                    1-palmityl-2-acetyl-sn-glycero-3-phosphate(2-) 0
                    4-chlorophenylacetate 0
                    4-hydroxyphenylacetate 0
                    calcium acetate + 0
                    chloroacetate 0
                    dichloroacetate 0
                    difluoroacetate 0
                    ethylammonium acetate 0
                    fluoroacetate + 0
                    glycolate + 0
                    guanidine acetate 0
                    haloacetate(1-) + 0
                    homogentisate 0
                    lead tetraacetate 6
                    lithium acetate 0
                    mandelate + 0
                    phenylacetate + 0
                    potassium acetate 0
                    sodium acetate + 30
                    trichloroacetate 0
                    trifluoroacetate + 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            organic ion 11448
                              organic anion 6850
                                carboxylic acid anion 2500
                                  monocarboxylic acid anion 1604
                                    acetate 41
                                      (2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl)acetate + 0
                                      (2,6-dihydroxyphenyl)acetate 0
                                      (5-oxo-2-sulfonato-2,5-dihydrofuran-2-yl)acetate 0
                                      1-palmityl-2-acetyl-sn-glycero-3-phosphate(2-) 0
                                      4-chlorophenylacetate 0
                                      4-hydroxyphenylacetate 0
                                      calcium acetate + 0
                                      chloroacetate 0
                                      dichloroacetate 0
                                      difluoroacetate 0
                                      ethylammonium acetate 0
                                      fluoroacetate + 0
                                      glycolate + 0
                                      guanidine acetate 0
                                      haloacetate(1-) + 0
                                      homogentisate 0
                                      lead tetraacetate 6
                                      lithium acetate 0
                                      mandelate + 0
                                      phenylacetate + 0
                                      potassium acetate 0
                                      sodium acetate + 30
                                      trichloroacetate 0
                                      trifluoroacetate + 5
paths to the root