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G |
Akt1 |
thymoma viral proto-oncogene 1 |
multiple interactions increases phosphorylation |
ISO EXP |
Genistein inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:20685402 PMID:23500011 |
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NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318
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G |
Alb |
albumin |
multiple interactions |
EXP |
ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]] |
CTD |
PMID:19376148 |
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NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases secretion multiple interactions increases expression |
ISO |
lipoteichoic acid results in increased secretion of CCL2 protein resveratrol inhibits the reaction [lipoteichoic acid results in increased secretion of CCL2 protein] lipoteichoic acid results in increased expression of CCL2 protein |
CTD |
PMID:23981542 PMID:29311626 |
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NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
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G |
Ccl20 |
C-C motif chemokine ligand 20 |
increases secretion |
ISO |
lipoteichoic acid results in increased secretion of CCL20 protein |
CTD |
PMID:15618187 |
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NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of CREB1 mRNA; [Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of CREB1 mRNA |
CTD |
PMID:19653804 |
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NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707
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G |
Csf2 |
colony stimulating factor 2 (granulocyte-macrophage) |
multiple interactions increases secretion |
ISO |
Dexamethasone inhibits the reaction [lipoteichoic acid results in increased secretion of CSF2 protein]; resveratrol inhibits the reaction [lipoteichoic acid results in increased secretion of CSF2 protein] |
CTD |
PMID:23981542 |
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NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493
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G |
Cxcl15 |
C-X-C motif chemokine ligand 15 |
increases secretion multiple interactions |
ISO |
lipoteichoic acid results in increased secretion of CXCL8 protein resveratrol inhibits the reaction [lipoteichoic acid results in increased secretion of CXCL8 protein] |
CTD |
PMID:22183712 PMID:23981542 |
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NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases expression |
ISO |
lipoteichoic acid results in increased expression of CXCL2 protein |
CTD |
PMID:29311626 |
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NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797
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G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
decreases expression |
ISO |
lipoteichoic acid results in decreased expression of CXCR2 protein |
CTD |
PMID:10950785 |
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NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405
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G |
Elane |
elastase, neutrophil expressed |
increases secretion multiple interactions |
ISO |
lipoteichoic acid results in increased secretion of ELANE protein Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of ELANE protein] |
CTD |
PMID:11302825 |
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NCBI chr10:79,722,146...79,724,050
Ensembl chr10:79,722,081...79,724,049
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G |
Grin1 |
glutamate receptor, ionotropic, NMDA1 (zeta 1) |
multiple interactions |
EXP |
[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN1 mRNA; [Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN1 mRNA |
CTD |
PMID:18926851 |
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NCBI chr 2:25,181,189...25,209,199
Ensembl chr 2:25,181,193...25,209,199
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G |
Grin2a |
glutamate receptor, ionotropic, NMDA2A (epsilon 1) |
multiple interactions |
EXP |
[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN2A mRNA; [Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN2A mRNA |
CTD |
PMID:18926851 PMID:19653804 |
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NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424
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G |
Grin2b |
glutamate receptor, ionotropic, NMDA2B (epsilon 2) |
increases expression multiple interactions |
EXP |
lipoteichoic acid results in increased expression of GRIN2B mRNA [Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN2B mRNA; [Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN2B mRNA; Particulate Matter promotes the reaction [lipoteichoic acid results in increased expression of GRIN2B mRNA]; Vehicle Emissions promotes the reaction [lipoteichoic acid results in increased expression of GRIN2B mRNA] |
CTD |
PMID:18926851 PMID:19653804 |
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NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
EXP ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; prolinedithiocarbamate inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein] |
CTD |
PMID:15316927 PMID:23500011 |
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NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
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G |
Il10 |
interleukin 10 |
increases expression multiple interactions |
ISO |
lipoteichoic acid results in increased expression of IL10 protein Sirolimus inhibits the reaction [lipoteichoic acid results in increased expression of IL10 protein] lipoteichoic acid results in increased expression of IL10 mRNA; lipoteichoic acid results in increased expression of IL10 protein |
CTD |
PMID:11169223 PMID:29311626 |
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NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
Genistein inhibits the reaction [lipoteichoic acid results in increased expression of IL1B]; Luteolin inhibits the reaction [lipoteichoic acid results in increased expression of IL1B]; quercetagetin inhibits the reaction [lipoteichoic acid results in increased expression of IL1B]; Quercetin inhibits the reaction [lipoteichoic acid results in increased expression of IL1B] lipoteichoic acid results in increased expression of IL1B; lipoteichoic acid results in increased expression of IL1B mRNA |
CTD |
PMID:20685402 PMID:29311626 |
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NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059
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G |
Il4 |
interleukin 4 |
increases expression |
ISO |
lipoteichoic acid results in increased expression of IL4 mRNA |
CTD |
PMID:29311626 |
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NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496
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G |
Il6 |
interleukin 6 |
increases secretion increases expression multiple interactions |
ISO EXP |
lipoteichoic acid results in increased secretion of IL6 protein lipoteichoic acid results in increased expression of IL6 protein 17 alpha-Hydroxyprogesterone Caproate inhibits the reaction [lipoteichoic acid results in increased expression of IL6 protein]; Protein Kinase Inhibitors inhibits the reaction [lipoteichoic acid results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [lipoteichoic acid results in increased secretion of IL6 protein] lipoteichoic acid results in increased expression of IL6 mRNA |
CTD |
PMID:20810098 PMID:23981542 PMID:28003376 PMID:29311626 |
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NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
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G |
Isg15 |
ISG15 ubiquitin-like modifier |
increases expression |
ISO |
lipoteichoic acid results in increased expression of ISG15 protein |
CTD |
PMID:32796029 |
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NCBI chr 4:156,283,881...156,285,275
Ensembl chr 4:156,283,912...156,285,253
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G |
Jun |
jun proto-oncogene |
multiple interactions increases phosphorylation |
EXP |
wogonin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of JUN protein] |
CTD |
PMID:17570322 PMID:23500011 |
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NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
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G |
Ltf |
lactotransferrin |
increases secretion multiple interactions |
ISO |
lipoteichoic acid results in increased secretion of LTF protein Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of LTF protein] |
CTD |
PMID:11302825 |
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NCBI chr 9:110,848,360...110,871,834
Ensembl chr 9:110,848,339...110,871,835
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G |
Map2k1 |
mitogen-activated protein kinase kinase 1 |
increases phosphorylation multiple interactions |
EXP |
lipoteichoic acid results in increased phosphorylation of MAP2K1 protein Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein] |
CTD |
PMID:19573522 |
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NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913
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G |
Map2k2 |
mitogen-activated protein kinase kinase 2 |
increases phosphorylation multiple interactions |
EXP |
lipoteichoic acid results in increased phosphorylation of MAP2K2 protein Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K2 protein] |
CTD |
PMID:19573522 |
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NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809
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G |
Mapk1 |
mitogen-activated protein kinase 1 |
multiple interactions increases phosphorylation |
EXP ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; zinc protoporphyrin promotes the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein] Genistein inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; Quercetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:18845389 PMID:19376148 PMID:19573522 PMID:20685402 PMID:23500011 |
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NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
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G |
Mapk3 |
mitogen-activated protein kinase 3 |
multiple interactions increases phosphorylation |
EXP ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin promotes the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein] Genistein inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; Luteolin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; Quercetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:18845389 PMID:19376148 PMID:19573522 PMID:20685402 PMID:23500011 |
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NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:23238562 |
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NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115
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G |
Nfkbia |
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha |
increases phosphorylation decreases expression |
EXP ISO |
lipoteichoic acid results in increased phosphorylation of NFKBIA protein lipoteichoic acid results in decreased expression of NFKBIA mRNA |
CTD |
PMID:23500011 PMID:29311626 |
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NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432
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G |
Nos2 |
nitric oxide synthase 2, inducible |
increases expression multiple interactions |
EXP ISO |
lipoteichoic acid results in increased expression of NOS2 mRNA; lipoteichoic acid results in increased expression of NOS2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; cobaltiprotoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; HMOX1 protein inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; prolinedithiocarbamate inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; Propofol inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; Propofol inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; SB 203580 inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; TLR2 protein affects the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein] |
CTD |
PMID:15316927 PMID:17570322 PMID:19376148 PMID:19497418 PMID:19573522 PMID:23500011 PMID:29311626 More...
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NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
increases expression |
ISO |
lipoteichoic acid results in increased expression of PTGS1 mRNA |
CTD |
PMID:29311626 |
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NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
EXP ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; prolinedithiocarbamate inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein] |
CTD |
PMID:23500011 |
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NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978
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G |
Raf1 |
v-raf-leukemia viral oncogene 1 |
increases phosphorylation multiple interactions |
EXP |
lipoteichoic acid results in increased phosphorylation of RAF1 protein Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein]; TLR2 protein affects the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein] |
CTD |
PMID:19573522 |
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NCBI chr 6:115,595,530...115,653,596
Ensembl chr 6:115,595,028...115,653,596
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G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
increases phosphorylation |
EXP |
lipoteichoic acid results in increased phosphorylation of RELA protein |
CTD |
PMID:23500011 |
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NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158
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G |
Tirap |
toll-interleukin 1 receptor (TIR) domain-containing adaptor protein |
multiple interactions |
EXP |
TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipoteichoic acid] |
CTD |
PMID:23238562 |
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NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587
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G |
Tlr2 |
toll-like receptor 2 |
multiple interactions increases activity |
EXP ISO |
[lipoteichoic acid binds to and results in increased activity of TLR2 protein] which results in increased expression of TNF mRNA; lipoteichoic acid binds to and results in increased activity of TLR2 protein; TLR2 protein affects the reaction [lipoteichoic acid results in increased abundance of Nitrites]; TLR2 protein affects the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; TLR2 protein affects the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein] lipoteichoic acid results in increased activity of TLR2 protein |
CTD |
PMID:18845389 PMID:19573522 PMID:28003376 |
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NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression increases secretion |
EXP ISO |
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of and results in increased secretion of TNF protein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of TNF mRNA]; [Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein; [lipoteichoic acid binds to and results in increased activity of TLR2 protein] which results in increased expression of TNF mRNA; cinnamaldehyde inhibits the reaction [lipoteichoic acid results in increased secretion of TNF protein]; Dactinomycin promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of TNF mRNA]]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [lipoteichoic acid results in increased secretion of TNF protein]; lipoteichoic acid results in increased expression of and results in increased secretion of TNF protein; Tetradecanoylphorbol Acetate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of and results in increased secretion of TNF protein]]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein] lipoteichoic acid results in increased expression of TNF protein |
CTD |
PMID:11169223 PMID:15618187 PMID:16373689 PMID:17868967 PMID:18845389 PMID:23238562 More...
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NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
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