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G |
AKT1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
ISO |
Genistein inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:20685402 PMID:23500011 |
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NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759
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G |
ALB |
albumin |
multiple interactions |
ISO |
ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]] |
CTD |
PMID:19376148 |
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NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
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G |
CCL2 |
C-C motif chemokine ligand 2 |
increases secretion increases expression multiple interactions |
EXP ISO |
lipoteichoic acid results in increased secretion of CCL2 protein lipoteichoic acid results in increased expression of CCL2 protein resveratrol inhibits the reaction [lipoteichoic acid results in increased secretion of CCL2 protein] |
CTD |
PMID:23981542 PMID:29311626 |
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NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208
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G |
CCL20 |
C-C motif chemokine ligand 20 |
increases secretion |
ISO |
lipoteichoic acid results in increased secretion of CCL20 protein |
CTD |
PMID:15618187 |
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NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564
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G |
CREB1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of CREB1 mRNA; [Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of CREB1 mRNA |
CTD |
PMID:19653804 |
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NCBI chr 2:207,529,962...207,605,988
Ensembl chr 2:207,529,737...207,605,988
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G |
CSF2 |
colony stimulating factor 2 |
multiple interactions increases secretion |
EXP |
Dexamethasone inhibits the reaction [lipoteichoic acid results in increased secretion of CSF2 protein]; resveratrol inhibits the reaction [lipoteichoic acid results in increased secretion of CSF2 protein] |
CTD |
PMID:23981542 |
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NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170
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G |
CXCL2 |
C-X-C motif chemokine ligand 2 |
increases expression |
ISO |
lipoteichoic acid results in increased expression of CXCL2 protein |
CTD |
PMID:29311626 |
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NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
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G |
CXCL8 |
C-X-C motif chemokine ligand 8 |
increases secretion multiple interactions |
EXP |
lipoteichoic acid results in increased secretion of CXCL8 protein resveratrol inhibits the reaction [lipoteichoic acid results in increased secretion of CXCL8 protein] |
CTD |
PMID:22183712 PMID:23981542 |
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NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
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G |
CXCR2 |
C-X-C motif chemokine receptor 2 |
decreases expression |
EXP |
lipoteichoic acid results in decreased expression of CXCR2 protein |
CTD |
PMID:10950785 |
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NCBI chr 2:218,125,294...218,137,251
Ensembl chr 2:218,125,289...218,137,251
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G |
ELANE |
elastase, neutrophil expressed |
increases secretion multiple interactions |
EXP |
lipoteichoic acid results in increased secretion of ELANE protein Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of ELANE protein] |
CTD |
PMID:11302825 |
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NCBI chr19:852,303...856,243
Ensembl chr19:851,014...856,247
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G |
GRIN1 |
glutamate ionotropic receptor NMDA type subunit 1 |
multiple interactions |
ISO |
[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN1 mRNA; [Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN1 mRNA |
CTD |
PMID:18926851 |
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NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756
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G |
GRIN2A |
glutamate ionotropic receptor NMDA type subunit 2A |
multiple interactions |
ISO |
[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN2A mRNA; [Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN2A mRNA |
CTD |
PMID:18926851 PMID:19653804 |
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NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,183,337
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G |
GRIN2B |
glutamate ionotropic receptor NMDA type subunit 2B |
increases expression multiple interactions |
ISO |
lipoteichoic acid results in increased expression of GRIN2B mRNA [Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN2B mRNA; [Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN2B mRNA; Particulate Matter promotes the reaction [lipoteichoic acid results in increased expression of GRIN2B mRNA]; Vehicle Emissions promotes the reaction [lipoteichoic acid results in increased expression of GRIN2B mRNA] |
CTD |
PMID:18926851 PMID:19653804 |
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NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002
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G |
HMOX1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; prolinedithiocarbamate inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein] |
CTD |
PMID:15316927 PMID:23500011 |
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NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
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G |
IL10 |
interleukin 10 |
increases expression multiple interactions |
EXP ISO |
lipoteichoic acid results in increased expression of IL10 protein lipoteichoic acid results in increased expression of IL10 mRNA; lipoteichoic acid results in increased expression of IL10 protein Sirolimus inhibits the reaction [lipoteichoic acid results in increased expression of IL10 protein] |
CTD |
PMID:11169223 PMID:29311626 |
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NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
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G |
IL1B |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
Genistein inhibits the reaction [lipoteichoic acid results in increased expression of IL1B]; Luteolin inhibits the reaction [lipoteichoic acid results in increased expression of IL1B]; quercetagetin inhibits the reaction [lipoteichoic acid results in increased expression of IL1B]; Quercetin inhibits the reaction [lipoteichoic acid results in increased expression of IL1B] lipoteichoic acid results in increased expression of IL1B; lipoteichoic acid results in increased expression of IL1B mRNA |
CTD |
PMID:20685402 PMID:29311626 |
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NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816
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G |
IL4 |
interleukin 4 |
increases expression |
ISO |
lipoteichoic acid results in increased expression of IL4 mRNA |
CTD |
PMID:29311626 |
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NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
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G |
IL6 |
interleukin 6 |
increases secretion increases expression multiple interactions |
EXP ISO |
lipoteichoic acid results in increased secretion of IL6 protein lipoteichoic acid results in increased expression of IL6 mRNA Protein Kinase Inhibitors inhibits the reaction [lipoteichoic acid results in increased expression of IL6 protein] 17 alpha-Hydroxyprogesterone Caproate inhibits the reaction [lipoteichoic acid results in increased expression of IL6 protein]; Protein Kinase Inhibitors inhibits the reaction [lipoteichoic acid results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [lipoteichoic acid results in increased secretion of IL6 protein] |
CTD |
PMID:20810098 PMID:23981542 PMID:28003376 PMID:29311626 |
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NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
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G |
ISG15 |
ISG15 ubiquitin like modifier |
increases expression |
EXP |
lipoteichoic acid results in increased expression of ISG15 protein |
CTD |
PMID:32796029 |
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NCBI chr 1:1,013,497...1,014,540
Ensembl chr 1:1,001,138...1,014,540
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases phosphorylation |
ISO |
wogonin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of JUN protein] |
CTD |
PMID:17570322 PMID:23500011 |
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NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
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G |
LTF |
lactotransferrin |
increases secretion multiple interactions |
EXP |
lipoteichoic acid results in increased secretion of LTF protein Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of LTF protein] |
CTD |
PMID:11302825 |
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NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234
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G |
MAP2K1 |
mitogen-activated protein kinase kinase 1 |
increases phosphorylation multiple interactions |
ISO |
lipoteichoic acid results in increased phosphorylation of MAP2K1 protein Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein] |
CTD |
PMID:19573522 |
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NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656
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G |
MAP2K2 |
mitogen-activated protein kinase kinase 2 |
increases phosphorylation multiple interactions |
ISO |
lipoteichoic acid results in increased phosphorylation of MAP2K2 protein Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K2 protein] |
CTD |
PMID:19573522 |
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NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; zinc protoporphyrin promotes the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein] Genistein inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; Quercetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:18845389 PMID:19376148 PMID:19573522 PMID:20685402 PMID:23500011 |
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NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin promotes the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein] Genistein inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; Luteolin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; Quercetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:18845389 PMID:19376148 PMID:19573522 PMID:20685402 PMID:23500011 |
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NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
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G |
MAPK8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:23238562 |
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NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360
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G |
NFKBIA |
NFKB inhibitor alpha |
increases phosphorylation decreases expression |
ISO |
lipoteichoic acid results in increased phosphorylation of NFKBIA protein lipoteichoic acid results in decreased expression of NFKBIA mRNA |
CTD |
PMID:23500011 PMID:29311626 |
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NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749
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G |
NOS2 |
nitric oxide synthase 2 |
increases expression multiple interactions |
ISO |
lipoteichoic acid results in increased expression of NOS2 mRNA; lipoteichoic acid results in increased expression of NOS2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; cobaltiprotoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; HMOX1 protein inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; prolinedithiocarbamate inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; Propofol inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; Propofol inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; SB 203580 inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; TLR2 protein affects the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein] |
CTD |
PMID:15316927 PMID:17570322 PMID:19376148 PMID:19497418 PMID:19573522 PMID:23500011 PMID:29311626 More...
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NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
increases expression |
ISO |
lipoteichoic acid results in increased expression of PTGS1 mRNA |
CTD |
PMID:29311626 |
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NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703
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G |
PTGS2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; prolinedithiocarbamate inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein] |
CTD |
PMID:23500011 |
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NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
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G |
RAF1 |
Raf-1 proto-oncogene, serine/threonine kinase |
increases phosphorylation multiple interactions |
ISO |
lipoteichoic acid results in increased phosphorylation of RAF1 protein Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein]; TLR2 protein affects the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein] |
CTD |
PMID:19573522 |
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NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201
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G |
RELA |
RELA proto-oncogene, NF-kB subunit |
increases phosphorylation |
ISO |
lipoteichoic acid results in increased phosphorylation of RELA protein |
CTD |
PMID:23500011 |
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NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090
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G |
TIRAP |
TIR domain containing adaptor protein |
multiple interactions |
ISO |
TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipoteichoic acid] |
CTD |
PMID:23238562 |
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NCBI chr11:126,283,093...126,294,933
Ensembl chr11:126,282,497...126,298,845
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G |
TLR2 |
toll like receptor 2 |
multiple interactions increases activity |
ISO EXP |
[lipoteichoic acid binds to and results in increased activity of TLR2 protein] which results in increased expression of TNF mRNA; lipoteichoic acid binds to and results in increased activity of TLR2 protein; TLR2 protein affects the reaction [lipoteichoic acid results in increased abundance of Nitrites]; TLR2 protein affects the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; TLR2 protein affects the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein] lipoteichoic acid results in increased activity of TLR2 protein |
CTD |
PMID:18845389 PMID:19573522 PMID:28003376 |
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NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,706,260
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G |
TNF |
tumor necrosis factor |
multiple interactions increases secretion increases expression |
ISO EXP |
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of and results in increased secretion of TNF protein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of TNF mRNA]; [Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein; [lipoteichoic acid binds to and results in increased activity of TLR2 protein] which results in increased expression of TNF mRNA; cinnamaldehyde inhibits the reaction [lipoteichoic acid results in increased secretion of TNF protein]; Dactinomycin promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of TNF mRNA]]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [lipoteichoic acid results in increased secretion of TNF protein]; lipoteichoic acid results in increased expression of and results in increased secretion of TNF protein; Tetradecanoylphorbol Acetate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of and results in increased secretion of TNF protein]]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein] lipoteichoic acid results in increased expression of TNF protein |
CTD |
PMID:11169223 PMID:15618187 PMID:16373689 PMID:17868967 PMID:18845389 PMID:23238562 More...
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NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
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