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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases phosphorylation |
EXP ISO |
Genistein inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; Luteolin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:20685402 PMID:23500011 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alb |
albumin |
multiple interactions |
ISO |
ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]] |
CTD |
PMID:19376148 |
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NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
increases secretion multiple interactions increases expression |
ISO EXP |
lipoteichoic acid results in increased secretion of CCL2 protein resveratrol inhibits the reaction [lipoteichoic acid results in increased secretion of CCL2 protein] lipoteichoic acid results in increased expression of CCL2 protein |
CTD |
PMID:23981542 PMID:29311626 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl20 |
C-C motif chemokine ligand 20 |
increases secretion |
EXP |
lipoteichoic acid results in increased secretion of CCL20 protein |
CTD |
PMID:15618187 |
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NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of CREB1 mRNA; [Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of CREB1 mRNA |
CTD |
PMID:19653804 |
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NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Csf2 |
colony stimulating factor 2 |
multiple interactions increases secretion |
ISO |
Dexamethasone inhibits the reaction [lipoteichoic acid results in increased secretion of CSF2 protein]; resveratrol inhibits the reaction [lipoteichoic acid results in increased secretion of CSF2 protein] |
CTD |
PMID:23981542 |
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NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
increases expression |
EXP |
lipoteichoic acid results in increased expression of CXCL2 protein |
CTD |
PMID:29311626 |
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NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcr2 |
C-X-C motif chemokine receptor 2 |
decreases expression |
ISO |
lipoteichoic acid results in decreased expression of CXCR2 protein |
CTD |
PMID:10950785 |
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NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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G |
Elane |
elastase, neutrophil expressed |
increases secretion multiple interactions |
ISO |
lipoteichoic acid results in increased secretion of ELANE protein Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of ELANE protein] |
CTD |
PMID:11302825 |
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NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
multiple interactions |
ISO |
[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN1 mRNA; [Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN1 mRNA |
CTD |
PMID:18926851 |
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NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
multiple interactions |
ISO |
[Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN2A mRNA; [Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN2A mRNA |
CTD |
PMID:18926851 PMID:19653804 |
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NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
increases expression multiple interactions |
ISO |
lipoteichoic acid results in increased expression of GRIN2B mRNA [Particulate Matter co-treated with lipoteichoic acid] results in increased expression of GRIN2B mRNA; [Vehicle Emissions co-treated with lipoteichoic acid] results in increased expression of GRIN2B mRNA; Particulate Matter promotes the reaction [lipoteichoic acid results in increased expression of GRIN2B mRNA]; Vehicle Emissions promotes the reaction [lipoteichoic acid results in increased expression of GRIN2B mRNA] |
CTD |
PMID:18926851 PMID:19653804 |
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NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein]; HMOX1 protein inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; prolinedithiocarbamate inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein]; SB 203580 inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein] |
CTD |
PMID:15316927 PMID:23500011 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Il10 |
interleukin 10 |
increases expression multiple interactions |
ISO EXP |
lipoteichoic acid results in increased expression of IL10 protein Sirolimus inhibits the reaction [lipoteichoic acid results in increased expression of IL10 protein] lipoteichoic acid results in increased expression of IL10 mRNA; lipoteichoic acid results in increased expression of IL10 protein |
CTD |
PMID:11169223 PMID:29311626 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
EXP |
Genistein inhibits the reaction [lipoteichoic acid results in increased expression of IL1B]; Luteolin inhibits the reaction [lipoteichoic acid results in increased expression of IL1B]; quercetagetin inhibits the reaction [lipoteichoic acid results in increased expression of IL1B]; Quercetin inhibits the reaction [lipoteichoic acid results in increased expression of IL1B] lipoteichoic acid results in increased expression of IL1B; lipoteichoic acid results in increased expression of IL1B mRNA |
CTD |
PMID:20685402 PMID:29311626 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il4 |
interleukin 4 |
increases expression |
EXP |
lipoteichoic acid results in increased expression of IL4 mRNA |
CTD |
PMID:29311626 |
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NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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G |
Il6 |
interleukin 6 |
increases secretion increases expression multiple interactions |
ISO EXP |
lipoteichoic acid results in increased secretion of IL6 protein lipoteichoic acid results in increased expression of IL6 protein 17 alpha-Hydroxyprogesterone Caproate inhibits the reaction [lipoteichoic acid results in increased expression of IL6 protein]; Protein Kinase Inhibitors inhibits the reaction [lipoteichoic acid results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [lipoteichoic acid results in increased secretion of IL6 protein] lipoteichoic acid results in increased expression of IL6 mRNA |
CTD |
PMID:20810098 PMID:23981542 PMID:28003376 PMID:29311626 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Isg15 |
ISG15 ubiquitin-like modifier |
increases expression |
ISO |
lipoteichoic acid results in increased expression of ISG15 protein |
CTD |
PMID:32796029 |
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NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases phosphorylation |
ISO |
wogonin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of JUN protein] |
CTD |
PMID:17570322 PMID:23500011 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Ltf |
lactotransferrin |
increases secretion multiple interactions |
ISO |
lipoteichoic acid results in increased secretion of LTF protein Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of LTF protein] |
CTD |
PMID:11302825 |
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NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
increases phosphorylation multiple interactions |
ISO |
lipoteichoic acid results in increased phosphorylation of MAP2K1 protein Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K1 protein] |
CTD |
PMID:19573522 |
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NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
increases phosphorylation multiple interactions |
ISO |
lipoteichoic acid results in increased phosphorylation of MAP2K2 protein Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAP2K2 protein] |
CTD |
PMID:19573522 |
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NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; zinc protoporphyrin promotes the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein] Genistein inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein]; Quercetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:18845389 PMID:19376148 PMID:19573522 PMID:20685402 PMID:23500011 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin promotes the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein] Genistein inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; Luteolin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; quercetagetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein]; Quercetin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:18845389 PMID:19376148 PMID:19573522 PMID:20685402 PMID:23500011 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:23238562 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Nfkbia |
NFKB inhibitor alpha |
increases phosphorylation decreases expression |
ISO EXP |
lipoteichoic acid results in increased phosphorylation of NFKBIA protein lipoteichoic acid results in decreased expression of NFKBIA mRNA |
CTD |
PMID:23500011 PMID:29311626 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
increases expression multiple interactions |
ISO EXP |
lipoteichoic acid results in increased expression of NOS2 mRNA; lipoteichoic acid results in increased expression of NOS2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; ALB protein inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; cobaltiprotoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; HMOX1 protein inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; prolinedithiocarbamate inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; Propofol inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; Propofol inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; pyrazolanthrone inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; SB 203580 inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; TLR2 protein affects the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein] |
CTD |
PMID:15316927 PMID:17570322 PMID:19376148 PMID:19497418 PMID:19573522 PMID:23500011 PMID:29311626 More...
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
increases expression |
EXP |
lipoteichoic acid results in increased expression of PTGS1 mRNA |
CTD |
PMID:29311626 |
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NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
ISO EXP |
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; Curcumin inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; prolinedithiocarbamate inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; tanshinone inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein] |
CTD |
PMID:23500011 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
increases phosphorylation multiple interactions |
ISO |
lipoteichoic acid results in increased phosphorylation of RAF1 protein Propofol inhibits the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein]; TLR2 protein affects the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein] |
CTD |
PMID:19573522 |
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NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
increases phosphorylation |
ISO |
lipoteichoic acid results in increased phosphorylation of RELA protein |
CTD |
PMID:23500011 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tirap |
TIR domain containing adaptor protein |
multiple interactions |
ISO |
TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipoteichoic acid] |
CTD |
PMID:23238562 |
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NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432
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G |
Tlr2 |
toll-like receptor 2 |
multiple interactions increases activity |
ISO |
[lipoteichoic acid binds to and results in increased activity of TLR2 protein] which results in increased expression of TNF mRNA; lipoteichoic acid binds to and results in increased activity of TLR2 protein; TLR2 protein affects the reaction [lipoteichoic acid results in increased abundance of Nitrites]; TLR2 protein affects the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; TLR2 protein affects the reaction [lipoteichoic acid results in increased phosphorylation of RAF1 protein] lipoteichoic acid results in increased activity of TLR2 protein |
CTD |
PMID:18845389 PMID:19573522 PMID:28003376 |
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NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression increases secretion |
ISO EXP |
2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of and results in increased secretion of TNF protein]; 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of TNF mRNA]; [Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein; [lipoteichoic acid binds to and results in increased activity of TLR2 protein] which results in increased expression of TNF mRNA; cinnamaldehyde inhibits the reaction [lipoteichoic acid results in increased secretion of TNF protein]; Dactinomycin promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of TNF mRNA]]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [lipoteichoic acid results in increased secretion of TNF protein]; lipoteichoic acid results in increased expression of and results in increased secretion of TNF protein; Tetradecanoylphorbol Acetate inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine inhibits the reaction [lipoteichoic acid results in increased expression of and results in increased secretion of TNF protein]]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein] lipoteichoic acid results in increased expression of TNF protein |
CTD |
PMID:11169223 PMID:15618187 PMID:16373689 PMID:17868967 PMID:18845389 PMID:23238562 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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