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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rifamycin SV
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Accession:CHEBI:29673 term browser browse the term
Definition:A member of the class of rifamycins that exhibits antibiotic and antitubercular properties.
Synonyms:exact_synonym: (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
 related_synonym: Formula=C37H47NO12;   InChI=1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1;   InChIKey=HJYYPODYNSCCOU-ODRIEIDWSA-N;   Rifamycin;   Rifocin;   Rifocyn;   SMILES=CO[C@H]1\\C=C\\O[C@@]2(C)Oc3c(C2=O)c2c(O)cc(NC(=O)\\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C;   rifamicina;   rifamycine;   rifamycinum
 xref: CAS:6998-60-3;   Drug_Central:4817;   KEGG:C12044;   KEGG:D02549;   LIPID_MAPS_instance:LMPK05000005
 xref_mesh: MESH:C023808
 xref: MetaCyc:CPD-10236;   PMID:25256628;   Reaxys:5401012
 cyclic_relationship: is_conjugate_acid_of CHEBI:84571


show annotations for term's descendants           Sort by:
rifamycin SV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 decreases activity EXP rifamycin SV results in decreased activity of ABCB11 protein CTD PMID:11343252 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Crp C-reactive protein, pentraxin-related affects expression ISO rifamycin SV affects the expression of CRP protein CTD PMID:1568518 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 multiple interactions EXP rifamycin SV inhibits the reaction [SLCO1A1 protein results in increased uptake of epyrifenacil metabolite] CTD PMID:34619012 NCBI chr 6:141,853,007...141,892,688
Ensembl chr 6:141,853,008...141,892,688 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions EXP rifamycin SV inhibits the reaction [SLCO1A4 protein results in increased uptake of epyrifenacil metabolite] CTD PMID:34619012 NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions
decreases activity		 ISO
EXP		 rifamycin SV inhibits the reaction [SLCO1B3 protein results in increased import of 8-sulfocholecystokinin octapeptide]; rifamycin SV inhibits the reaction [SLCO1B3 protein results in increased uptake of epyrifenacil metabolite]
rifamycin SV results in decreased activity of SLCO1B3 protein
rifamycin SV inhibits the reaction [SLCO1B2 protein results in increased uptake of epyrifenacil metabolite]		 CTD PMID:27450509 PMID:31364238 PMID:34619012 NCBI chr 6:141,575,178...141,632,372
Ensembl chr 6:141,575,244...141,632,372 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22276
    role 22261
      biological role 22260
        antimicrobial agent 19655
          rifamycin SV 5
            rifamycin SV hemiaminal 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22276
    subatomic particle 22271
      composite particle 22271
        hadron 22271
          baryon 22271
            nucleon 22271
              atomic nucleus 22271
                atom 22271
                  main group element atom 22150
                    p-block element atom 22150
                      carbon group element atom 21953
                        carbon atom 21893
                          organic molecular entity 21893
                            heteroorganic entity 21532
                              organochalcogen compound 21029
                                organooxygen compound 20877
                                  carbon oxoacid 19627
                                    carboxylic acid 19623
                                      carboacyl group 18287
                                        univalent carboacyl group 18287
                                          carbamoyl group 18107
                                            carboxamide 18107
                                              lactam 8460
                                                ansamycin 881
                                                  rifamycins 429
                                                    rifamycin SV 5
                                                      rifamycin SV hemiaminal 0
paths to the root