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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rifamycin SV
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Accession:CHEBI:29673 term browser browse the term
Definition:A member of the class of rifamycins that exhibits antibiotic and antitubercular properties.
Synonyms:exact_synonym: (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate
 related_synonym: Formula=C37H47NO12;   InChI=1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1;   InChIKey=HJYYPODYNSCCOU-ODRIEIDWSA-N;   Rifamycin;   Rifocin;   Rifocyn;   SMILES=CO[C@H]1\\C=C\\O[C@@]2(C)Oc3c(C2=O)c2c(O)cc(NC(=O)\\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C;   rifamicina;   rifamycine;   rifamycinum
 xref: CAS:6998-60-3;   Drug_Central:4817;   KEGG:C12044;   KEGG:D02549;   LIPID_MAPS_instance:LMPK05000005
 xref_mesh: MESH:C023808
 xref: MetaCyc:CPD-10236;   PMID:25256628;   Reaxys:5401012
 cyclic_relationship: is_conjugate_acid_of CHEBI:84571


show annotations for term's descendants           Sort by:
rifamycin SV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases activity ISO rifamycin SV results in decreased activity of ABCB11 protein CTD PMID:11343252 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G CRP C-reactive protein affects expression EXP rifamycin SV affects the expression of CRP protein CTD PMID:1568518 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 decreases activity
multiple interactions		 EXP rifamycin SV results in decreased activity of SLCO1B1 protein
rifamycin SV inhibits the reaction [SLCO1B1 protein results in increased transport of estradiol-17 beta-glucuronide]		 CTD PMID:15616150 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796 		JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 multiple interactions
decreases activity		 EXP
ISO		 rifamycin SV inhibits the reaction [SLCO1B3 protein results in increased import of 8-sulfocholecystokinin octapeptide]; rifamycin SV inhibits the reaction [SLCO1B3 protein results in increased uptake of epyrifenacil metabolite]
rifamycin SV results in decreased activity of SLCO1B3 protein
rifamycin SV inhibits the reaction [SLCO1B2 protein results in increased uptake of epyrifenacil metabolite]		 CTD PMID:27450509 PMID:31364238 PMID:34619012 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26496
    role 26318
      biological role 26297
        antimicrobial agent 22503
          rifamycin SV 4
            rifamycin SV hemiaminal 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26496
    subatomic particle 26472
      composite particle 26472
        hadron 26472
          baryon 26472
            nucleon 26472
              atomic nucleus 26472
                atom 26472
                  main group element atom 26208
                    p-block element atom 26208
                      carbon group element atom 25651
                        carbon atom 25613
                          organic molecular entity 25613
                            heteroorganic entity 24994
                              organochalcogen compound 24590
                                organooxygen compound 24184
                                  carbon oxoacid 22798
                                    carboxylic acid 22778
                                      carboacyl group 20070
                                        univalent carboacyl group 20070
                                          carbamoyl group 19594
                                            carboxamide 19594
                                              lactam 8849
                                                ansamycin 915
                                                  rifamycins 452
                                                    rifamycin SV 4
                                                      rifamycin SV hemiaminal 0
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