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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ascomycin
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Accession:CHEBI:29582 term browser browse the term
Definition:A macrolide that is produced by the fermentation of Streptomyces hygroscopicus and exhibits strong immunosuppressant properties.
Synonyms:exact_synonym: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-8-ethyl-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
 related_synonym: FK 520;   FK520;   FR 900520;   Formula=C43H69NO12;   Immunomycin;   InChI=1S/C43H69NO12/c1-10-30-18-24(2)17-25(3)19-36(53-8)39-37(54-9)21-27(5)43(51,56-39)40(48)41(49)44-16-12-11-13-31(44)42(50)55-38(28(6)33(46)23-34(30)47)26(4)20-29-14-15-32(45)35(22-29)52-7/h18,20,25,27-33,35-39,45-46,51H,10-17,19,21-23H2,1-9H3/b24-18+,26-20+/t25-,27+,28+,29-,30+,31-,32+,33-,35+,36-,37-,38+,39+,43+/m0/s1;   InChIKey=ZDQSOHOQTUFQEM-NURRSENYSA-N;   L 683590;   SMILES=CC[C@@H]1\\C=C(C)\\C[C@H](C)C[C@H](OC)[C@H]2O[C@](O)([C@H](C)C[C@@H]2OC)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@@H]([C@H](C)[C@@H](O)CC1=O)C(\\C)=C\\[C@@H]1CC[C@@H](O)[C@@H](C1)OC
 xref: CAS:104987-12-4;   KEGG:C12102;   KNApSAcK:C00017631
 xref_mesh: MESH:C058028
 xref: PMID:21833838;   PMID:23435975;   PMID:24628911;   PMID:3198493;   PMID:7520900;   Reaxys:5372600;   Wikipedia:Ascomycin


show annotations for term's descendants           Sort by:
ascomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fkbp1a FKBP prolyl isomerase 1A multiple interactions ISO
EXP 		immunomycin inhibits the reaction [Sirolimus binds to FKBP1A protein] CTD PMID:7503980 PMID:7532117 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:160,500,726...160,524,233 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP
ISO 		[Okadaic Acid co-treated with immunomycin] results in increased phosphorylation of MAPT protein CTD PMID:7723735 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        immunomodulator 15130
          immunosuppressive agent 13986
            ascomycin 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  ester 17805
                                    carboxylic ester 17260
                                      lactone 13419
                                        macrocyclic lactone 7630
                                          macrolide 7579
                                            ascomycin 2
paths to the root