gold atom - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	gold atom	go back to main search page
Accession:	CHEBI:29287	browse the term
Definition:	A copper group element atom that has formula Au.
Synonyms:	related_synonym:	79Au; Au; Formula=Au; Gold; InChI=1S/Au; InChIKey=PCHJSUWPFVWCPO-UHFFFAOYSA-N; SMILES=[Au]; aurum; or; oro
	xref:	CAS:7440-57-5
	xref_mesh:	MESH:D006046
	xref:	WebElements:Au

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Rat (614) Mouse (622) Human (636) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (622)

gold atom

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 4931406C07 gene

decreases expression

Gold results in decreased expression of C11ORF54 mRNA

NCBI chr 9:15,194,633...15,217,836
Ensembl chr 9:15,194,633...15,217,744

G

aminoadipate-semialdehyde synthase

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of AASS mRNA
Gold analog results in decreased expression of AASS mRNA

PMID:28433809 PMID:36057382

NCBI chr 6:23,072,172...23,132,985
Ensembl chr 6:23,072,172...23,132,985

G

ATP-binding cassette, sub-family B member 1A

increases expression

Gold analog results in increased expression of ABCB1 mRNA

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

ATP-binding cassette, sub-family B member 4

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCB4 mRNA
Gold analog results in decreased expression of ABCB4 mRNA

PMID:28433809 PMID:36057382

NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231

G

ATP-binding cassette, sub-family C member 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCC1 mRNA

NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601

G

ATP-binding cassette, sub-family member 2

increases expression

Gold analog results in increased expression of ABCC2 mRNA

NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179

G

c-abl oncogene 1, non-receptor tyrosine kinase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ABL1 mRNA

NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239

G

acetyl-Coenzyme A acyltransferase 1B

decreases expression

Gold analog results in decreased expression of ACAA1 mRNA

NCBI chr 9:118,977,111...118,986,149
Ensembl chr 9:118,977,091...118,986,161

G

acetyl-Coenzyme A carboxylase alpha

decreases expression

Gold analog results in decreased expression of ACACA mRNA

NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477

G

acyl-Coenzyme A dehydrogenase family, member 11

decreases expression

Gold analog results in decreased expression of ACAD11 mRNA

NCBI chr 9:103,940,923...104,004,855
Ensembl chr 9:103,940,576...104,004,924

G

acyl-Coenzyme A dehydrogenase, medium chain

decreases expression

Gold analog results in decreased expression of ACADM mRNA

NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269

G

acyl-Coenzyme A dehydrogenase, short chain

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADS mRNA

NCBI chr 5:115,248,358...115,257,405
Ensembl chr 5:115,248,358...115,257,405

G

acyl-Coenzyme A dehydrogenase, very long chain

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADVL mRNA

NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237

G

acyl-coenzyme A amino acid N-acyltransferase 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ACNAT2 mRNA

NCBI chr 4:49,374,458...49,408,151
Ensembl chr 4:49,379,840...49,408,151

G

aconitase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of ACO1 mRNA

NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338

G

aconitase 2, mitochondrial

decreases expression
multiple interactions

Gold analog results in decreased expression of ACO2 protein
[Polyethyleneimine binds to Gold] which results in increased expression of ACO2 mRNA

PMID:24780912 PMID:28433809

NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334

G

acyl-Coenzyme A oxidase 1, palmitoyl

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ACOX1 mRNA

NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871

G

acyl-Coenzyme A oxidase 2, branched chain

decreases expression

Gold analog results in decreased expression of ACOX2 mRNA

NCBI chr14:14,210,406...14,244,262
Ensembl chr14:14,210,420...14,244,262

G

acid phosphatase 1, soluble

decreases expression

Gold results in decreased expression of ACP1 mRNA

NCBI chr12:30,943,325...30,961,616
Ensembl chr12:30,943,325...30,961,588

G

activin A receptor, type IC

decreases expression

Gold results in decreased expression of ACVR1C mRNA

NCBI chr 2:58,157,465...58,247,909
Ensembl chr 2:58,157,465...58,247,907

G

a disintegrin and metallopeptidase domain 28

increases expression

Gold results in increased expression of ADAM28 mRNA

NCBI chr14:68,842,447...68,893,338
Ensembl chr14:68,843,476...68,893,291

G

alcohol dehydrogenase 5 (class III), chi polypeptide

decreases expression

Gold results in decreased expression of ADH5 mRNA

NCBI chr 3:138,142,961...138,161,260
Ensembl chr 3:138,148,854...138,161,260

G

adiponectin receptor 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ADIPOR2 mRNA

NCBI chr 6:119,330,111...119,394,489
Ensembl chr 6:119,330,111...119,394,665

G

adrenergic receptor, alpha 1b

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRA1B mRNA

NCBI chr11:43,665,432...43,792,076
Ensembl chr11:43,665,433...43,792,037

G

adrenergic receptor, beta 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRB2 mRNA

NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030

G

alpha-2-HS-glycoprotein

decreases expression

Gold analog results in decreased expression of AHSG mRNA

NCBI chr16:22,710,793...22,718,193
Ensembl chr16:22,710,027...22,718,199

G

apoptosis-inducing factor, mitochondrion-associated 1

increases expression

Gold results in increased expression of AIFM1 protein

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

decreases expression

Gold results in decreased expression of AIMP1 mRNA

NCBI chr 3:132,366,259...132,390,151
Ensembl chr 3:132,366,242...132,390,131

G

adenylate kinase 3

decreases expression

Gold results in decreased expression of AK3 mRNA

NCBI chr19:28,968,715...29,026,122
Ensembl chr19:28,998,233...29,025,361

G

A kinase anchor protein 13

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of AKAP13 mRNA

NCBI chr 7:75,105,271...75,404,357
Ensembl chr 7:75,105,282...75,404,357

G

aldo-keto reductase family 1, member B10

increases expression

Gold results in increased expression of AKR1B10 mRNA

NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885

G

aldo-keto reductase family 1, member C18

increases expression

Gold results in increased expression of AKR1C3 mRNA

NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653

G

aldo-keto reductase family 1, member C21

increases expression

Gold results in increased expression of AKR1C2 mRNA

NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540

G

thymoma viral proto-oncogene 1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of AKT1 protein

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

albumin

multiple interactions
increases expression

ALB protein results in increased uptake of [Polyethylene Glycols binds to Gold]; ALB protein results in increased uptake of [Polyethyleneimine binds to Gold]; ALB protein results in increased uptake of [Thioctic Acid binds to Gold]
Gold analog results in increased expression of ALB mRNA

PMID:28433809 PMID:36057382

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

annexin A5

increases expression

Gold analog results in increased expression of ANXA5 protein

NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043

G

apoptotic peptidase activating factor 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of APAF1 mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein
Gold analog results in decreased expression of APAF1 mRNA

PMID:27470402 PMID:28433809 PMID:36057382

NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632

G

apurinic/apyrimidinic endonuclease 1

decreases expression

Gold analog results in decreased expression of APEX1 mRNA

NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596

G

apolipoprotein A-IV

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of APOA4 mRNA

NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757

G

adenine phosphoribosyl transferase

decreases expression

Gold analog results in decreased expression of APRT protein

NCBI chr 8:123,301,376...123,303,646
Ensembl chr 8:123,301,374...123,303,648

G

aquaporin 4

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of AQP4 mRNA

NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039

G

ADP-ribosylation factor-like 1

decreases expression

Gold results in decreased expression of ARL1 mRNA

NCBI chr10:88,566,720...88,579,956
Ensembl chr10:88,566,720...88,579,956

G

ADP-ribosylation factor-like 5B

decreases expression

Gold results in decreased expression of ARL5B mRNA

NCBI chr 2:15,060,066...15,087,267
Ensembl chr 2:15,054,206...15,087,267

G

arylsulfatase G

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ARSG mRNA

NCBI chr11:109,364,159...109,464,156
Ensembl chr11:109,364,200...109,464,156

G

N-acylsphingosine amidohydrolase 1

decreases expression

Gold analog results in decreased expression of ASAH1 mRNA

NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810

G

activating transcription factor 1

decreases expression

Gold results in decreased expression of ATF1 mRNA

NCBI chr15:100,125,729...100,159,129
Ensembl chr15:100,125,700...100,159,125

G

activating transcription factor 4

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ATF4 mRNA

NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742

G

activating transcription factor 6

increases cleavage

Gold analog results in increased cleavage of ATF6 protein

NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

decreases expression

Gold analog results in decreased expression of ATIC protein

NCBI chr 1:71,596,315...71,618,562
Ensembl chr 1:71,596,309...71,618,790

G

atlastin GTPase 2

decreases expression

Gold results in decreased expression of ATL2 mRNA

NCBI chr17:80,155,819...80,203,633
Ensembl chr17:80,155,819...80,203,552

G

ataxia telangiectasia mutated

decreases expression

Gold analog results in decreased expression of ATM mRNA

NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040

G

ATPase, Ca++ transporting, plasma membrane 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ATP2B1 mRNA

NCBI chr10:98,750,243...98,862,005
Ensembl chr10:98,750,268...98,862,005

G

ATP synthase F1 subunit beta

multiple interactions

Gold analog results in increased expression of and results in decreased phosphorylation of ATP5F1B protein

NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260

G

ATPase, H+ transporting, lysosomal V1 subunit G2

decreases expression

Gold analog results in decreased expression of ATP6V1G2 mRNA

NCBI chr17:35,453,910...35,457,743
Ensembl chr17:35,452,636...35,457,743

G

ataxia telangiectasia and Rad3 related

decreases expression

Gold analog results in decreased expression of ATR mRNA

NCBI chr 9:95,739,655...95,834,813
Ensembl chr 9:95,739,650...95,833,834

G

beta-site APP cleaving enzyme 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BACE1 mRNA

NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697

G

BCL2-associated agonist of cell death

multiple interactions

[Quercetin analog co-treated with Gold analog] results in increased expression of BAD protein

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

brain-specific angiogenesis inhibitor 1-associated protein 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of BAIAP2 mRNA

NCBI chr11:119,833,762...119,897,608
Ensembl chr11:119,833,589...119,897,608

G

BCL2-antagonist/killer 1

increases expression

Gold results in increased expression of BAK1 mRNA

NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983

G

BCL2-associated X protein

multiple interactions
increases expression

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein; [Gold analog co-treated with Platinum] results in increased expression of BAX mRNA; [Polyethyleneimine binds to Gold] which results in decreased expression of BAX mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of BAX protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of BAX protein
Gold results in increased expression of BAX mRNA

PMID:21621595 PMID:22178767 PMID:25846798 PMID:27470402 PMID:27836789 More...

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

BCAS2 pre-mRNA processing factor

decreases expression

Gold results in decreased expression of BCAS2 mRNA

NCBI chr 3:103,078,971...103,086,479
Ensembl chr 3:103,078,971...103,086,482

G

B cell leukemia/lymphoma 2

multiple interactions

[Gold analog co-treated with Platinum] results in decreased expression of BCL2 mRNA; [Quercetin analog co-treated with Gold analog] results in decreased expression of BCL2 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in decreased expression of BCL2 protein

PMID:25846798 PMID:27470402 PMID:27836789

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of BCL2L1 mRNA

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

BCL2 like 11

decreases expression

Gold analog results in decreased expression of BCL2L11 mRNA

NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467

G

baculoviral IAP repeat-containing 2

decreases expression

Gold results in decreased expression of BIRC2 mRNA

NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065

G

baculoviral IAP repeat-containing 3

decreases expression

Gold analog results in decreased expression of BIRC3 mRNA; Gold results in decreased expression of BIRC3 mRNA

PMID:25523186 PMID:36057382

NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187

G

basic helix-loop-helix ARNT like 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BMAL1 mRNA

NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333

G

Bmi1 polycomb ring finger oncogene

decreases expression

Gold results in decreased expression of BMI1 mRNA

NCBI chr 2:18,681,953...18,691,440
Ensembl chr 2:18,681,829...18,691,440

G

breast cancer 1, early onset

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA1 mRNA
Gold analog results in decreased expression of BRCA1 mRNA

PMID:28433809 PMID:36057382

NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781

G

breast cancer 2, early onset

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA2 mRNA
Gold analog results in decreased expression of BRCA2 mRNA

PMID:28433809 PMID:36057382

NCBI chr 5:150,445,759...150,493,612
Ensembl chr 5:150,446,095...150,493,794

G

C1D nuclear receptor co-repressor

decreases expression

Gold results in decreased expression of C1D mRNA

NCBI chr11:17,207,547...17,219,176
Ensembl chr11:17,207,579...17,219,176

G

complement component 3

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of C3 mRNA

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

complement component 9

decreases expression

Gold analog results in decreased expression of C9 mRNA

NCBI chr15:6,474,827...6,528,306
Ensembl chr15:6,474,808...6,528,232

G

capping actin protein of muscle Z-line subunit alpha 2

decreases expression

Gold results in decreased expression of CAPZA2 mRNA

NCBI chr 6:17,637,009...17,666,971
Ensembl chr 6:17,636,233...17,666,971

G

carbonic anhydrase 13

decreases expression

Gold results in decreased expression of CA13 mRNA

NCBI chr 3:14,706,787...14,728,062
Ensembl chr 3:14,706,787...14,728,062

G

caspase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of CASP1 mRNA

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

caspase 3

multiple interactions
increases activity
increases cleavage
increases expression

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP3 mRNA; [Polyethyleneimine binds to Gold] which results in increased expression of CASP3 mRNA; [Quercetin analog co-treated with Gold analog] results in increased cleavage of CASP3 protein; [Quercetin analog co-treated with Gold analog] results in increased expression of and results in increased activity of CASP3 protein; Dexamethasone promotes the reaction [Gold results in increased activity of CASP3 protein]; Etoposide promotes the reaction [Gold results in increased activity of CASP3 protein]
Gold analog results in increased cleavage of CASP3 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP3 protein
Gold results in increased expression of CASP3 mRNA

PMID:19760634 PMID:21621595 PMID:22178767 PMID:25846798 PMID:26551149 More...

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 4, apoptosis-related cysteine peptidase

increases cleavage

Gold analog results in increased cleavage of CASP4 protein

NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783

G

caspase 7

increases cleavage

Gold analog results in increased cleavage of CASP7 protein

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

caspase 8

increases expression
decreases expression

Gold results in increased expression of CASP8 mRNA
Gold analog results in decreased expression of CASP8 mRNA

PMID:22178767 PMID:36057382

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions
increases cleavage

[Gold analog co-treated with Platinum] results in increased activity of CASP9 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP9 mRNA
Gold analog results in increased cleavage of CASP9 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP9 protein

PMID:25846798 PMID:26551149 PMID:27836789

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

multiple interactions

[Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

chromobox 3

decreases expression

Gold results in decreased expression of CBX3 mRNA

NCBI chr 6:51,447,596...51,460,684
Ensembl chr 6:51,447,340...51,460,684

G

C-C motif chemokine ligand 2

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL2 protein
Gold results in increased secretion of CCL2 protein

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 5

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL5 protein
Gold results in increased secretion of CCL5 protein

NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344

G

C-C motif chemokine ligand 7

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL7 protein
Gold results in increased secretion of CCL7 protein

NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351

G

cyclin D1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased expression of CCND1 protein

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

chaperonin containing TCP1 subunit 5

decreases expression

Gold analog results in decreased expression of CCT5 protein

NCBI chr15:31,590,946...31,601,992
Ensembl chr15:31,590,946...31,601,950

G

CD19 antigen

increases expression

Gold analog results in increased expression of CD19 mRNA

NCBI chr 7:126,007,620...126,016,401
Ensembl chr 7:126,007,622...126,014,061

G

CD36 molecule

decreases expression

Gold analog results in decreased expression of CD36 mRNA

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

G

CD40 antigen

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CD40 mRNA

NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868

G

CD86 antigen

decreases expression

Gold analog results in decreased expression of CD86 mRNA

NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443

G

cytidine deaminase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CDA mRNA

NCBI chr 4:138,065,839...138,095,623
Ensembl chr 4:138,065,735...138,095,303

G

cyclin dependent kinase 1

decreases expression
increases expression

Gold results in decreased expression of CDK1 mRNA
Gold results in increased expression of CDK1 mRNA

PMID:25523186 PMID:29705079

NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768

G

cyclin dependent kinase 7

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CDK7 mRNA

NCBI chr13:100,833,532...100,867,454
Ensembl chr13:100,839,139...100,867,447

G

cyclin dependent kinase inhibitor 1B

multiple interactions

[Gold binds to Dimethyldithiocarbamate] which results in increased expression of CDKN1B protein

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

CDKN2A interacting protein

decreases expression

Gold results in decreased expression of CDKN2AIP mRNA

NCBI chr 8:48,162,379...48,166,966
Ensembl chr 8:48,162,379...48,166,967

G

cell growth regulator with ring finger domain 1

decreases expression

Gold results in decreased expression of CGRRF1 mRNA

NCBI chr14:47,069,591...47,091,655
Ensembl chr14:47,069,582...47,091,650

G

checkpoint kinase 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA
Gold analog results in decreased expression of CHEK1 mRNA

PMID:28433809 PMID:36057382

NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361

G

checkpoint kinase 2

decreases expression

Gold analog results in decreased expression of CHEK2 mRNA

NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011

G

cysteine and histidine rich domain containing 1

decreases expression

Gold results in decreased expression of CHORDC1 mRNA

NCBI chr 9:18,203,563...18,225,296
Ensembl chr 9:18,203,421...18,228,738

G

CDGSH iron sulfur domain 1

decreases expression

Gold results in decreased expression of CISD1 mRNA

NCBI chr10:71,166,324...71,180,679
Ensembl chr10:71,166,310...71,180,784

G

claudin 12

decreases expression

Gold results in decreased expression of CLDN12 mRNA

NCBI chr 5:5,555,109...5,564,953
Ensembl chr 5:5,539,537...5,564,958

G

cellular nucleic acid binding protein

decreases expression

Gold results in decreased expression of CNBP mRNA

NCBI chr 6:87,819,597...87,828,088
Ensembl chr 6:87,819,597...87,828,088

G

CCR4-NOT transcription complex, subunit 7

decreases expression

Gold results in decreased expression of CNOT7 mRNA

NCBI chr 8:40,945,579...40,968,888
Ensembl chr 8:40,945,581...40,968,888

G

collagen, type I, alpha 1

increases expression

Gold analog results in increased expression of COL1A1 protein

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type I, alpha 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL1A2 mRNA

NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544

G

collagen, type III, alpha 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL3A1 mRNA

NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866

G

COMM domain containing 8

decreases expression

Gold results in decreased expression of COMMD8 mRNA

NCBI chr 5:72,313,919...72,325,532
Ensembl chr 5:72,313,918...72,325,532

G

cytochrome c oxidase assembly protein 11, copper chaperone

decreases expression

Gold results in decreased expression of COX11 mRNA

NCBI chr11:90,529,010...90,536,803
Ensembl chr11:90,528,999...90,535,757

G

cytochrome c oxidase assembly protein 17, copper chaperone

decreases expression

Gold results in decreased expression of COX17 mRNA

NCBI chr16:38,167,332...38,173,125
Ensembl chr16:38,167,353...38,182,659

G

carnitine palmitoyltransferase 1a, liver

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT1A mRNA

NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733

G

carnitine palmitoyltransferase 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT2 mRNA

NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807

G

carnitine O-octanoyltransferase

decreases expression

Gold analog results in decreased expression of CROT mRNA

NCBI chr 5:9,016,033...9,047,926
Ensembl chr 5:9,016,033...9,047,324

G

colony stimulating factor 2 (granulocyte-macrophage)

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF2 protein
Gold results in increased secretion of CSF2 protein

NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493

G

colony stimulating factor 3 (granulocyte)

increases secretion
multiple interactions

Gold results in increased secretion of CSF3 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF3 protein

NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455

G

CCCTC-binding factor

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CTCF mRNA

NCBI chr 8:106,351,135...106,409,554
Ensembl chr 8:106,363,200...106,409,554

G

cut-like homeobox 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CUX1 mRNA

NCBI chr 5:136,276,989...136,596,429
Ensembl chr 5:136,276,989...136,596,344

G

C-X-C motif chemokine ligand 10

increases secretion
multiple interactions

Gold results in increased secretion of CXCL10 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL10 protein

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

C-X-C motif chemokine ligand 2

multiple interactions
increases secretion

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL2 mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL2 protein
Gold results in increased secretion of CXCL2 protein

PMID:19695318 PMID:22155353

NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797

G

C-X-C motif chemokine ligand 3

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL1 mRNA

NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459

G

cytochrome c, somatic

multiple interactions

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of CYCS protein

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
decreases expression
multiple interactions

Gold analog results in increased activity of CYP1A1 protein
Gold analog results in decreased expression of CYP1A1 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of CYP1A1 mRNA

PMID:20193702 PMID:28433809 PMID:36057382

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 24, subfamily a, polypeptide 1

increases expression

Gold results in increased expression of CYP24A1 mRNA

NCBI chr 2:170,324,877...170,339,065
Ensembl chr 2:170,324,628...170,339,065

G

cytochrome P450, family 2, subfamily d, polypeptide 22

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA
Gold analog results in decreased expression of CYP2D6 mRNA

PMID:28433809 PMID:36057382

NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

Gold analog results in decreased expression of CYP2E1 mRNA

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

cytochrome P450, family 3, subfamily a, polypeptide 11

increases expression

Gold analog results in increased expression of CYP3A11 mRNA

NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774

G

cytochrome P450, family 7, subfamily a, polypeptide 1

increases expression

Gold analog results in increased expression of CYP7A1 mRNA

NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633

G

cytohesin 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CYTH1 mRNA

NCBI chr11:118,054,996...118,139,452
Ensembl chr11:118,022,845...118,139,386

G

disabled 2, mitogen-responsive phosphoprotein

increases expression

Gold results in increased expression of DAB2 mRNA

NCBI chr15:6,329,269...6,470,196
Ensembl chr15:6,329,269...6,470,193

G

decapping mRNA 2

decreases expression

Gold results in decreased expression of DCP2 mRNA

NCBI chr18:44,513,567...44,558,036
Ensembl chr18:44,513,569...44,558,036

G

dopa decarboxylase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DDC mRNA

NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144

G

DNA-damage inducible transcript 3

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of DDIT3 mRNA

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

DNA-damage-inducible transcript 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of DDIT4 mRNA

NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656

G

defensin beta 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DEFB1 mRNA

NCBI chr 8:22,266,571...22,285,201
Ensembl chr 8:22,266,615...22,285,201

G

24-dehydrocholesterol reductase

multiple interactions
decreases expression

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DHCR24 mRNA
Gold analog results in decreased expression of DHCR24 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of DHCR24 mRNA

PMID:19695318 PMID:28433809 PMID:36057382

NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310

G

dihydrolipoamide dehydrogenase

decreases expression

Gold analog results in decreased expression of DLD mRNA

NCBI chr12:31,381,561...31,401,470
Ensembl chr12:31,381,276...31,401,452

G

dynein, axonemal, heavy chain 14

decreases expression

Gold results in decreased expression of DNAH14 mRNA

NCBI chr 1:181,404,158...181,642,306
Ensembl chr 1:181,404,124...181,643,339

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of DNAJA3 mRNA

NCBI chr16:4,501,934...4,525,559
Ensembl chr16:4,457,853...4,525,559

G

DnaJ heat shock protein family (Hsp40) member B14

decreases expression

Gold results in decreased expression of DNAJB14 mRNA

NCBI chr 3:137,572,801...137,619,350
Ensembl chr 3:137,573,436...137,622,318

G

DnaJ heat shock protein family (Hsp40) member B6

decreases expression

Gold results in decreased expression of DNAJB6 mRNA

NCBI chr 5:29,940,896...29,991,476
Ensembl chr 5:29,940,686...30,023,132

G

DnaJ heat shock protein family (Hsp40) member B9

decreases expression

Gold results in decreased expression of DNAJB9 mRNA

NCBI chr12:44,252,680...44,256,851
Ensembl chr12:44,252,342...44,257,109

G

DnaJ heat shock protein family (Hsp40) member C10

decreases expression

Gold results in decreased expression of DNAJC10 mRNA

NCBI chr 2:80,145,790...80,184,399
Ensembl chr 2:80,145,810...80,184,387

G

DnaJ heat shock protein family (Hsp40) member C19

decreases expression

Gold results in decreased expression of DNAJC19 mRNA

NCBI chr 3:34,111,429...34,135,503
Ensembl chr 3:34,110,169...34,135,470

G

DnaJ heat shock protein family (Hsp40) member C21

decreases expression

Gold results in decreased expression of DNAJC21 mRNA

NCBI chr15:10,446,849...10,470,685
Ensembl chr15:10,446,842...10,470,602

G

DnaJ heat shock protein family (Hsp40) member C5

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DNAJC5 mRNA

NCBI chr 2:181,162,141...181,194,679
Ensembl chr 2:181,162,278...181,196,926

G

dihydropyrimidinase-like 4

increases expression

Gold analog results in increased expression of DPYSL4 mRNA

NCBI chr 7:138,665,917...138,681,711
Ensembl chr 7:138,665,917...138,682,620

G

dopamine receptor D3

multiple interactions

Gold inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]

NCBI chr16:43,574,285...43,646,353
Ensembl chr16:43,574,389...43,643,295

G

dopamine receptor D4

multiple interactions

Gold inhibits the reaction [3-N-methylspiperone binds to DRD4 protein]

NCBI chr 7:140,871,931...140,874,868
Ensembl chr 7:140,871,919...140,876,377

G

desmocollin 2

increases expression

Gold results in increased expression of DSC2 mRNA

NCBI chr18:20,163,690...20,192,611
Ensembl chr18:20,163,690...20,192,611

G

desmoglein 2

increases expression

Gold results in increased expression of DSG2 mRNA

NCBI chr18:20,691,247...20,737,583
Ensembl chr18:20,691,131...20,737,578

G

dual oxidase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DUOX1 mRNA

NCBI chr 2:122,143,525...122,178,454
Ensembl chr 2:122,146,153...122,178,453

G

dual oxidase 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DUOX2 mRNA

NCBI chr 2:122,109,727...122,129,221
Ensembl chr 2:122,109,728...122,128,930

G

dual specificity phosphatase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of DUSP1 mRNA

NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102

G

dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)

decreases expression

Gold results in decreased expression of DUSP11 mRNA

NCBI chr 6:85,919,250...85,938,950
Ensembl chr 6:85,919,250...85,938,649

G

deoxyuridine triphosphatase

decreases expression

Gold results in decreased expression of DUT mRNA

NCBI chr 2:125,089,168...125,100,969
Ensembl chr 2:125,089,110...125,100,528

G

DAZ interacting protein 3, zinc finger

decreases expression

Gold results in decreased expression of DZIP3 mRNA

NCBI chr16:48,744,591...48,814,505
Ensembl chr16:48,744,595...48,814,528

G

ER degradation enhancer, mannosidase alpha-like 3

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of EDEM3 mRNA
Gold analog results in decreased expression of EDEM3 mRNA

PMID:28433809 PMID:36057382

NCBI chr 1:151,631,099...151,698,079
Ensembl chr 1:151,631,122...151,697,802

G

early endosome antigen 1

decreases expression

Gold results in decreased expression of EEA1 mRNA

NCBI chr10:95,776,525...95,881,380
Ensembl chr10:95,776,512...95,881,380

G

eukaryotic translation elongation factor 1 delta

decreases expression

Gold analog results in decreased expression of EEF1D protein

NCBI chr15:75,766,643...75,781,425
Ensembl chr15:75,766,054...75,781,405

G

eukaryotic translation elongation factor 2

decreases expression

Gold analog results in decreased expression of EEF2 protein

NCBI chr10:81,012,465...81,018,343
Ensembl chr10:81,012,465...81,018,332

G

epidermal growth factor

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965

G

epidermal growth factor receptor

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158

G

enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase

decreases expression

Gold analog results in decreased expression of EHHADH mRNA

NCBI chr16:21,580,035...21,606,589
Ensembl chr16:21,580,037...21,606,557

G

EP300 interacting inhibitor of differentiation 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of EID1 mRNA

NCBI chr 2:125,515,020...125,517,563
Ensembl chr 2:125,515,015...125,516,705

G

eukaryotic translation initiation factor 1A, X-linked

decreases expression

Gold results in decreased expression of EIF1AX mRNA

NCBI chr X:158,155,174...158,172,617
Ensembl chr X:158,155,174...158,172,924

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation

Gold analog results in increased phosphorylation of EIF2AK3 protein

NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229

G

eukaryotic translation initiation factor 4A2

decreases expression

Gold results in decreased expression of EIF4A2 mRNA

NCBI chr16:22,924,846...22,932,882
Ensembl chr16:22,926,194...22,932,886

G

eukaryotic translation initiation factor 4E

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased expression of EIF4E protein

NCBI chr 3:138,231,952...138,265,457
Ensembl chr 3:138,231,940...138,265,457

G

eukaryotic translation initiation factor 4E binding protein 3

multiple interactions

[Quercetin analog co-treated with Gold analog] results in increased expression of EIF4EBP3 protein

NCBI chr18:36,797,113...36,799,377
Ensembl chr18:36,797,113...36,798,970

G

eukaryotic translation initiation factor 5B

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of EIF5B mRNA
Gold analog results in decreased expression of EIF5B mRNA

PMID:28433809 PMID:36057382

NCBI chr 1:38,037,091...38,094,660
Ensembl chr 1:38,037,091...38,094,660

G

enolase 1, alpha non-neuron

multiple interactions

Gold analog results in decreased expression of and results in increased phosphorylation of ENO1 protein

NCBI chr 4:150,321,165...150,333,336
Ensembl chr 4:150,321,178...150,333,336
Ensembl chr18:150,321,178...150,333,336

G

E1A binding protein p300

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]; [Polyethyleneimine binds to Gold] which results in decreased expression of EP300 mRNA; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]

PMID:27634460 PMID:28433809

NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278

G

epithelial mitogen

increases expression

Gold results in increased expression of EPGN mRNA

NCBI chr 5:91,175,376...91,183,071
Ensembl chr 5:91,175,323...91,183,074

G

Eph receptor A1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of EPHA1 mRNA

NCBI chr 6:42,335,421...42,350,249
Ensembl chr 6:42,335,421...42,350,202

G

epoxide hydrolase 1, microsomal

increases expression

Gold analog results in increased expression of EPHX1 mRNA

NCBI chr 1:180,817,121...180,845,134
Ensembl chr 1:180,803,775...180,848,469

G

excision repair cross-complementing rodent repair deficiency, complementation group 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ERCC2 mRNA

NCBI chr 7:19,115,942...19,129,619
Ensembl chr 7:19,115,935...19,129,619

G

excision repair cross-complementing rodent repair deficiency, complementation group 6

decreases expression

Gold analog results in decreased expression of ERCC6 mRNA

NCBI chr14:32,235,248...32,302,947
Ensembl chr14:32,235,478...32,302,947

G

endoplasmic reticulum to nucleus signalling 1

increases phosphorylation

Gold analog results in increased phosphorylation of ERN1 protein

NCBI chr11:106,285,474...106,378,701
Ensembl chr11:106,285,476...106,378,678

G

endoplasmic reticulum to nucleus signalling 2

increases expression

Gold analog results in increased expression of ERN2 mRNA

NCBI chr 7:121,769,116...121,785,454
Ensembl chr 7:121,769,116...121,785,430

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

Gold results in increased expression of ERO1A mRNA

NCBI chr14:45,520,544...45,556,029
Ensembl chr14:45,520,544...45,556,228

G

establishment of sister chromatid cohesion N-acetyltransferase 2

decreases expression

Gold results in decreased expression of ESCO2 mRNA

NCBI chr14:66,056,476...66,071,418
Ensembl chr14:66,056,487...66,071,443

G

estrogen receptor 1 (alpha)

decreases expression

Gold analog results in decreased expression of ESR1 mRNA

NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614

G

expressed sequence EU599041

decreases expression

Gold results in decreased expression of ZNF124 mRNA

NCBI chr 7:42,863,463...42,876,676
Ensembl chr 7:42,863,422...42,901,968

G

ecotropic viral integration site 5

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of EVI5 mRNA

NCBI chr 5:107,892,661...108,022,973
Ensembl chr 5:107,892,661...108,022,973

G

even-skipped homeobox 1

increases expression

Gold results in increased expression of EVX1 mRNA

NCBI chr 6:52,290,483...52,295,374
Ensembl chr 6:52,290,483...52,295,363

G

Fanconi anemia, complementation group L

decreases expression

Gold results in decreased expression of FANCL mRNA

NCBI chr11:26,337,084...26,421,883
Ensembl chr11:26,336,135...26,421,876

G

Fas cell surface death receptor

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of FAS mRNA
Gold analog results in decreased expression of FAS mRNA

PMID:28433809 PMID:36057382

NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172

G

fatty acid synthase

decreases expression

Gold analog results in decreased expression of FASN mRNA

NCBI chr11:120,696,784...120,715,992
Ensembl chr11:120,696,672...120,715,373

G

fibroblast growth factor 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of FGF1 mRNA

NCBI chr18:38,971,725...39,062,532
Ensembl chr18:38,971,726...39,062,525

G

fumarate hydratase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of FH mRNA

NCBI chr 1:175,428,944...175,453,201
Ensembl chr 1:175,427,940...175,453,201

G

FK506 binding protein 9

increases phosphorylation
decreases expression

Gold analog results in increased phosphorylation of FKBP9 protein
Gold analog results in decreased expression of FKBP9 protein

NCBI chr 6:56,809,044...56,856,345
Ensembl chr 6:56,809,044...56,856,343

G

flavin containing monooxygenase 5

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of FMO5 mRNA

NCBI chr 3:97,517,248...97,562,603
Ensembl chr 3:97,536,120...97,562,598

G

FBJ osteosarcoma oncogene

multiple interactions
increases expression

[Gold co-treated with Silicon Dioxide] results in increased expression of FOS mRNA
Gold results in increased expression of FOS mRNA

NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047

G

ferritin heavy polypeptide 1

increases expression

Gold results in increased expression of FTH1 mRNA

NCBI chr19:9,957,964...9,962,475
Ensembl chr19:9,957,962...9,962,462

G

FYN binding protein 1

increases expression

Gold results in increased expression of FYB1 mRNA

NCBI chr15:6,552,280...6,695,089
Ensembl chr15:6,552,334...6,692,794

G

frizzled class receptor 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of FZD4 mRNA

NCBI chr 7:89,053,574...89,062,341
Ensembl chr 7:89,053,563...89,062,342

G

G2/M-phase specific E3 ubiquitin ligase

decreases expression

Gold results in decreased expression of G2E3 mRNA

NCBI chr12:51,395,013...51,423,769
Ensembl chr12:51,394,844...51,423,769

G

polypeptide N-acetylgalactosaminyltransferase 1

decreases expression

Gold results in decreased expression of GALNT1 mRNA

NCBI chr18:24,338,401...24,419,873
Ensembl chr18:24,338,401...24,419,875

G

polypeptide N-acetylgalactosaminyltransferase 5

decreases expression

Gold analog results in decreased expression of GALNT5 mRNA

NCBI chr 2:57,887,832...57,931,039
Ensembl chr 2:57,887,896...57,935,872

G

glucosidase, alpha; neutral C

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of GANC mRNA

NCBI chr 2:120,234,377...120,291,347
Ensembl chr 2:120,234,377...120,292,181

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

Gold analog results in decreased expression of GAPDH protein

NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430

G

grancalcin

decreases expression

Gold results in decreased expression of GCA mRNA

NCBI chr 2:62,494,671...62,524,453
Ensembl chr 2:62,494,629...62,524,453

G

glutaryl-Coenzyme A dehydrogenase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of GCDH mRNA

NCBI chr 8:85,613,016...85,629,378
Ensembl chr 8:85,613,022...85,620,550

G

guanine monophosphate synthetase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of GMPS mRNA

NCBI chr 3:63,871,054...63,928,975
Ensembl chr 3:63,883,527...63,930,000

G

guanine nucleotide binding protein (G protein), gamma 10

decreases expression

Gold results in decreased expression of GNG10 mRNA

NCBI chr 4:59,035,156...59,041,899
Ensembl chr 4:59,035,088...59,041,903

G

glutamatic-oxaloacetic transaminase 2, mitochondrial

decreases expression

Gold analog results in decreased expression of GOT2 protein

NCBI chr 8:96,590,761...96,615,029
Ensembl chr 8:96,590,762...96,615,175

G

G protein-coupled receptor 182

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of GPR182 mRNA

NCBI chr10:127,585,471...127,587,667
Ensembl chr10:127,583,145...127,587,601

G

glutamic pyruvic transaminase, soluble

multiple interactions
decreases expression

[Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; [Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]
Gold analog results in decreased expression of GPT mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of GPT mRNA

PMID:27836789 PMID:28433809 PMID:36057382

NCBI chr15:76,580,926...76,583,875
Ensembl chr15:76,579,916...76,583,886

G

glutathione peroxidase 2

increases expression

Gold analog results in increased expression of GPX2 mRNA; Gold results in increased expression of GPX2 mRNA

PMID:25523186 PMID:36057382

NCBI chr12:76,839,109...76,842,328
Ensembl chr12:76,839,107...76,842,273

G

glutathione peroxidase 3

increases expression

Gold analog results in increased expression of GPX3 mRNA

NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203

G

gelsolin

decreases expression
increases degradation

Gold analog results in decreased expression of GSN protein
Gold analog results in increased degradation of GSN protein

PMID:24780912 PMID:26551149

NCBI chr 2:35,146,371...35,197,914
Ensembl chr 2:35,146,392...35,197,904

G

glutathione S-transferase, mu 4

multiple interactions
increases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of GSTM4 mRNA
Gold analog results in increased expression of GSTM4 mRNA

PMID:28433809 PMID:36057382

NCBI chr 3:107,937,887...107,952,495
Ensembl chr 3:107,947,724...107,952,210

G

histocompatibility 2, class II antigen E beta

increases expression

Gold analog results in increased expression of HLA-DRB1 mRNA

NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648

G

histocompatibility 2, M region locus 2

affects response to substance

HLA-B gene polymorphism affects the susceptibility to Gold

NCBI chr17:37,791,742...37,794,445
Ensembl chr17:37,791,742...37,794,443

G

3-hydroxyanthranilate 3,4-dioxygenase

increases expression

Gold analog results in increased expression of HAAO mRNA

NCBI chr17:84,138,777...84,157,589
Ensembl chr17:84,138,585...84,155,392

G

histone aminotransferase 1

decreases expression

Gold results in decreased expression of HAT1 mRNA

NCBI chr 2:71,219,604...71,271,966
Ensembl chr 2:71,219,302...71,271,966

G

hepatitis A virus cellular receptor 1

multiple interactions

[Polyethylene Glycols binds to Gold] which results in increased expression of HAVCR1 protein; [Polyethyleneimine binds to Gold] which results in increased expression of HAVCR1 protein; [Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein

NCBI chr11:46,630,644...46,670,405
Ensembl chr11:46,625,907...46,670,405

G

hexosaminidase B

multiple interactions

[gold chloride results in increased abundance of Gold] which results in increased export of HEXB protein; [gold tetrachloride, acid results in increased abundance of Gold] which results in increased export of HEXB protein

NCBI chr13:97,312,839...97,334,865
Ensembl chr13:97,312,839...97,334,865

G

high mobility group box 2

decreases expression

Gold results in decreased expression of HMGB2 mRNA

NCBI chr 8:57,964,877...57,969,033
Ensembl chr 8:57,964,941...57,969,033

G

heme oxygenase 1

increases expression

Gold results in increased expression of HMOX1 mRNA

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

homeobox A3

decreases expression

Gold analog results in decreased expression of HOXA3 mRNA

NCBI chr 6:52,146,039...52,190,316
Ensembl chr 6:52,146,042...52,190,316

G

hypoxanthine phosphoribosyltransferase 1

decreases expression

Gold results in decreased expression of HPRT1 mRNA

NCBI chr X:52,076,955...52,110,537
Ensembl chr X:52,077,014...52,110,536

G

hemopexin

decreases expression

Gold analog results in decreased expression of HPX mRNA

NCBI chr 7:105,240,818...105,249,323
Ensembl chr 7:105,240,820...105,249,344

G

heat shock factor binding protein 1

decreases expression

Gold results in decreased expression of HSBP1 mRNA

NCBI chr 8:120,071,277...120,075,668
Ensembl chr 8:120,071,227...120,075,661

G

heat shock factor 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of HSF1 mRNA

NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113

G

heat shock protein 90 alpha (cytosolic), class B member 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSP90AB1 mRNA

NCBI chr17:45,878,704...45,884,187
Ensembl chr17:45,878,701...45,884,197

G

heat shock protein 70 family, member 13

decreases expression

Gold results in decreased expression of HSPA13 mRNA

NCBI chr16:75,552,078...75,564,575
Ensembl chr16:75,542,319...75,563,992

G

heat shock protein 1A

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of HSPA1A mRNA

NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132

G

heat shock protein 1B

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of HSPA1B mRNA

NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214

G

heat shock protein 2

decreases expression

Gold analog results in decreased expression of HSPA2 mRNA

NCBI chr12:76,450,688...76,453,712
Ensembl chr12:76,450,950...76,453,712

G

heat shock protein 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSPA4 mRNA

NCBI chr11:53,150,641...53,191,306
Ensembl chr11:53,150,641...53,191,284

G

heat shock protein 8

increases expression

Gold analog results in increased expression of HSPA8 protein

NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383

G

heat shock protein 9

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of HSPA9 mRNA

NCBI chr18:35,070,467...35,087,404
Ensembl chr18:35,070,467...35,087,410

G

heat shock protein 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSPB1 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of HSPB1 mRNA

PMID:19695318 PMID:28433809

NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417

G

heat shock protein 1 (chaperonin)

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of HSPD1 mRNA

NCBI chr 1:55,116,992...55,127,402
Ensembl chr 1:55,116,994...55,127,402

G

HIV-1 Tat interactive protein 2

increases expression

Gold results in increased expression of HTATIP2 mRNA

NCBI chr 7:49,408,761...49,423,748
Ensembl chr 7:49,408,863...49,423,723

G

HIV TAT specific factor 1

decreases expression

Gold results in decreased expression of HTATSF1 mRNA

NCBI chr X:56,098,930...56,112,543
Ensembl chr X:56,098,943...56,112,543

G

HtrA serine peptidase 4

decreases expression

Gold analog results in decreased expression of HTRA4 mRNA

NCBI chr 8:25,514,944...25,529,160
Ensembl chr 8:25,514,945...25,528,978

G

hypoxia up-regulated 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of HYOU1 mRNA

NCBI chr 9:44,290,840...44,303,662
Ensembl chr 9:44,290,787...44,303,666

G

isocitrate dehydrogenase 1 (NADP+), soluble

multiple interactions

Gold analog results in decreased expression of and results in increased phosphorylation of IDH1 protein

NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659

G

isocitrate dehydrogenase 3 (NAD+), gamma

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of IDH3G mRNA

NCBI chr X:72,822,569...72,830,471
Ensembl chr X:72,822,569...72,830,503

G

interferon gamma receptor 1

increases expression

Gold results in increased expression of IFNGR1 mRNA

NCBI chr10:19,467,697...19,485,977
Ensembl chr10:19,467,697...19,485,977

G

insulin-like growth factor 1

multiple interactions

Gold inhibits the reaction [IGF1 protein binds to IGF1R protein]

NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904

G

insulin-like growth factor I receptor

multiple interactions

Gold inhibits the reaction [IGF1 protein binds to IGF1R protein]; Gold inhibits the reaction [IGF2 protein binds to IGF1R protein]

NCBI chr 7:67,601,486...67,883,416
Ensembl chr 7:67,602,575...67,883,416

G

insulin-like growth factor 2

multiple interactions

Gold inhibits the reaction [IGF2 protein binds to IGF1R protein]

NCBI chr 7:142,204,505...142,220,566
Ensembl chr 7:142,204,503...142,220,553

G

IKAROS family zinc finger 2

decreases expression

Gold results in decreased expression of IKZF2 mRNA

NCBI chr 1:69,570,382...69,726,510
Ensembl chr 1:69,570,373...69,726,404

G

interleukin 10

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of IL10 protein
Gold results in increased secretion of IL10 protein

NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711

G

interleukin 1 alpha

multiple interactions
decreases expression
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of IL1A protein
Gold analog results in decreased expression of IL1A mRNA
Gold results in increased secretion of IL1A protein

PMID:22155353 PMID:36057382

NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892

G

interleukin 1 beta

multiple interactions
decreases expression
increases secretion

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL1B mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of IL1B protein
Gold analog results in decreased expression of IL1B mRNA
Gold results in increased secretion of IL1B protein

PMID:19695318 PMID:22155353 PMID:36057382

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 4

decreases expression

Gold analog results in decreased expression of IL4 mRNA

NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496

G

interleukin 6

multiple interactions
increases secretion

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL6 mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of IL6 protein
[Polyethylene Glycols binds to Gold] which results in increased expression of IL6 protein; [Polyethyleneimine binds to Gold] which results in increased expression of IL6 protein; [Thioctic Acid binds to Gold] which results in increased expression of IL6 protein
Gold results in increased secretion of IL6 protein

PMID:19695318 PMID:22155353 PMID:28433809

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interleukin 6 receptor, alpha

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL6RA mRNA

NCBI chr 3:89,776,631...89,820,503
Ensembl chr 3:89,771,366...89,820,503

G

inositol (myo)-1(or 4)-monophosphatase 1

decreases expression

Gold results in decreased expression of IMPA1 mRNA

NCBI chr 3:10,377,016...10,396,499
Ensembl chr 3:10,377,016...10,396,499

G

inositol polyphosphate multikinase

decreases expression

Gold results in decreased expression of IPMK mRNA

NCBI chr10:71,183,574...71,221,715
Ensembl chr10:71,183,593...71,269,157

G

IQ motif containing GTPase activating protein 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of IQGAP2 mRNA

NCBI chr13:95,763,685...96,028,788
Ensembl chr13:95,763,682...96,028,991

G

jagged 1

decreases expression

Gold analog results in decreased expression of JAG1 mRNA

NCBI chr 2:136,923,371...136,958,440
Ensembl chr 2:136,923,376...136,958,564

G

Janus kinase 2

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of JAK2 protein

NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480

G

jun proto-oncogene

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459

G

junction plakoglobin

decreases expression

Gold analog results in decreased expression of JUP protein

NCBI chr11:100,259,682...100,288,639
Ensembl chr11:100,259,784...100,288,589

G

ketohexokinase

increases expression

Gold analog results in increased expression of KHK mRNA

NCBI chr 5:31,078,780...31,088,592
Ensembl chr 5:31,078,775...31,088,592

G

Kin17 DNA and RNA binding protein

decreases expression

Gold results in decreased expression of KIN mRNA

NCBI chr 2:10,085,397...10,097,512
Ensembl chr 2:10,085,404...10,097,617

G

kit ligand

decreases expression

Gold results in decreased expression of KITLG mRNA

NCBI chr10:99,851,477...99,936,278
Ensembl chr10:99,851,492...99,936,278

G

KRR1, small subunit (SSU) processome component, homolog (yeast)

decreases expression

Gold results in decreased expression of KRR1 mRNA

NCBI chr10:111,808,600...111,824,335
Ensembl chr10:111,808,569...111,824,337

G

kynureninase

increases expression

Gold results in increased expression of KYNU mRNA

NCBI chr 2:43,445,270...43,572,734
Ensembl chr 2:43,445,341...43,572,734

G

laccase domain containing 1

increases expression

Gold results in increased expression of LACC1 mRNA

NCBI chr14:77,261,640...77,274,344
Ensembl chr14:77,261,640...77,274,344

G

lactamase, beta 2

decreases expression

Gold results in decreased expression of LACTB2 mRNA

NCBI chr 1:13,695,069...13,730,749
Ensembl chr 1:13,693,554...13,730,770

G

La ribonucleoprotein 1B

decreases expression

Gold results in decreased expression of LARP1B mRNA

NCBI chr 3:40,904,198...40,994,642
Ensembl chr 3:40,904,263...40,994,669

G

leukemia inhibitory factor

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of LIF protein
Gold results in increased secretion of LIF protein

NCBI chr11:4,207,587...4,222,514
Ensembl chr11:4,207,557...4,222,514

G

ligase IV, DNA, ATP-dependent

multiple interactions

[Polyethyleneimine binds to Gold] which affects the expression of LIG4 mRNA

NCBI chr 8:10,020,020...10,027,680
Ensembl chr 8:10,019,049...10,027,686

G

LIM domain and actin binding 1

decreases expression

Gold results in decreased expression of LIMA1 mRNA

NCBI chr15:99,676,351...99,773,292
Ensembl chr15:99,676,351...99,773,337

G

lectin, mannose-binding, 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of LMAN1 mRNA

NCBI chr18:66,113,810...66,135,706
Ensembl chr18:66,113,809...66,155,651

G

lamin A

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of LMNA mRNA

NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263

G

lamin B1

increases degradation

Gold analog results in increased degradation of LMNB1 protein

NCBI chr18:56,840,885...56,886,496
Ensembl chr18:56,840,885...56,886,496

G

lysophosphatidylglycerol acyltransferase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of LPGAT1 mRNA

NCBI chr 1:191,449,682...191,516,367
Ensembl chr 1:191,449,946...191,516,367

G

LRAT domain containing 1

increases expression

Gold results in increased expression of LRATD1 mRNA

NCBI chr12:14,197,599...14,202,039
Ensembl chr12:14,196,831...14,202,055

G

LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

Gold results in decreased expression of LSM5 mRNA

NCBI chr 6:56,678,048...56,681,684
Ensembl chr 6:56,678,048...56,681,695

G

LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

Gold results in decreased expression of LSM6 mRNA

NCBI chr 8:79,531,497...79,547,781
Ensembl chr 8:79,531,494...79,547,769

G

lanosterol synthase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of LSS mRNA

NCBI chr10:76,367,303...76,392,973
Ensembl chr10:76,367,422...76,392,972

G

MAD2 mitotic arrest deficient-like 1

decreases expression

Gold results in decreased expression of MAD2L1 mRNA

NCBI chr 6:66,512,205...66,518,091
Ensembl chr 6:66,512,374...66,524,204

G

microtubule-associated protein 1B

increases expression

Gold results in increased expression of MAP1B mRNA

NCBI chr13:99,557,972...99,653,110
Ensembl chr13:99,557,954...99,653,048

G

mitogen-activated protein kinase kinase 1

multiple interactions

MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr 9:64,093,066...64,160,887
Ensembl chr 9:64,093,052...64,160,913

G

muscleblind like splicing factor 2

decreases expression

Gold results in decreased expression of MBNL2 mRNA

NCBI chr14:120,513,077...120,669,110
Ensembl chr14:120,513,081...120,669,109

G

malate dehydrogenase 1B, NAD (soluble)

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of MDH1B mRNA
Gold analog results in decreased expression of MDH1B mRNA

PMID:28433809 PMID:36057382

NCBI chr 1:63,726,732...63,769,707
Ensembl chr 1:63,737,978...63,769,477

G

transformed mouse 3T3 cell double minute 2

decreases expression

Gold analog results in decreased expression of MDM2 mRNA

NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663

G

mitochondrial trans-2-enoyl-CoA reductase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MECR mRNA

NCBI chr 4:131,570,755...131,595,097
Ensembl chr 4:131,570,781...131,595,097

G

Mediterranean fever

increases expression

Gold results in increased expression of MEFV mRNA

NCBI chr16:3,524,838...3,536,073
Ensembl chr16:3,525,082...3,535,961

G

methionine aminopeptidase 2

decreases expression

Gold analog results in decreased expression of METAP2 mRNA; Gold results in decreased expression of METAP2 mRNA

PMID:25523186 PMID:36057382

NCBI chr10:93,694,351...93,732,952
Ensembl chr10:93,694,351...93,732,955

G

antigen identified by monoclonal antibody Ki 67

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in increased expression of MKI67 mRNA
Gold analog results in decreased expression of MKI67 mRNA

PMID:28433809 PMID:36057382

NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090

G

membrane magnesium transporter 1

decreases expression

Gold results in decreased expression of MMGT1 mRNA

NCBI chr X:55,630,872...55,643,304
Ensembl chr X:55,630,872...55,643,429

G

matrix metallopeptidase 3

increases expression

Gold results in increased expression of MMP3 mRNA

NCBI chr 9:7,445,845...7,455,975
Ensembl chr 9:7,445,822...7,455,975

G

matrix metallopeptidase 9

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]

NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770

G

menage a trois 1

decreases expression

Gold results in decreased expression of MNAT1 mRNA

NCBI chr12:73,158,957...73,320,762
Ensembl chr12:73,170,491...73,320,762

G

MOB kinase activator 1B

decreases expression

Gold results in decreased expression of MOB1B mRNA

NCBI chr 5:88,868,730...88,906,314
Ensembl chr 5:88,868,714...88,912,079

G

MOB family member 4, phocein

decreases expression

Gold results in decreased expression of MOB4 mRNA

NCBI chr 1:55,170,404...55,194,058
Ensembl chr 1:55,170,390...55,194,058

G

microrchidia 3

decreases expression

Gold results in decreased expression of MORC3 mRNA

NCBI chr16:93,629,009...93,672,964
Ensembl chr16:93,629,009...93,672,961

G

mitochondrial ribosomal protein L3

decreases expression

Gold results in decreased expression of MRPL3 mRNA

NCBI chr 9:104,930,394...104,954,665
Ensembl chr 9:104,930,438...104,957,087

G

mitochondrial ribosomal protein S6

decreases expression

Gold results in decreased expression of MRPS6 mRNA

NCBI chr16:91,855,224...91,909,115
Ensembl chr16:91,855,158...91,909,115

G

metallothionein 1

increases expression

Gold results in increased expression of MT1X mRNA

NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955

G

metallothionein 2

increases expression

Gold results in increased expression of MT2A mRNA

NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196

G

methylenetetrahydrofolate reductase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MTHFR mRNA

NCBI chr 4:148,123,534...148,144,019
Ensembl chr 4:148,123,534...148,144,008

G

myotubularin related protein 6

decreases expression

Gold results in decreased expression of MTMR6 mRNA

NCBI chr14:60,488,941...60,539,820
Ensembl chr14:60,502,677...60,539,819

G

mechanistic target of rapamycin kinase

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of MTOR protein

NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140

G

MTSS I-BAR domain containing 1

increases expression

Gold results in increased expression of MTSS1 mRNA

NCBI chr15:58,813,083...58,955,805
Ensembl chr15:58,813,083...58,953,854

G

microsomal triglyceride transfer protein

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of MTTP mRNA

NCBI chr 3:137,795,616...137,849,179
Ensembl chr 3:137,795,615...137,850,729

G

v-myc avian myelocytomatosis viral oncogene lung carcinoma derived

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MYCL mRNA

NCBI chr 4:122,889,414...122,896,278
Ensembl chr 4:122,889,445...122,896,278

G

myoneurin

decreases expression

Gold results in decreased expression of MYNN mRNA

NCBI chr 3:30,656,212...30,674,022
Ensembl chr 3:30,656,214...30,674,022

G

N-acyl phosphatidylethanolamine phospholipase D

decreases expression

Gold results in decreased expression of NAPEPLD mRNA

NCBI chr 5:21,867,899...21,906,620
Ensembl chr 5:21,867,899...21,906,394

G

neutral cholesterol ester hydrolase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of NCEH1 mRNA

NCBI chr 3:27,237,153...27,299,112
Ensembl chr 3:27,237,114...27,338,757

G

nuclear factor, erythroid derived 2, like 2

increases activity
increases expression

Gold results in increased activity of NFE2L2 promoter
Gold analog results in increased expression of NFE2L2 mRNA; Gold analog results in increased expression of NFE2L2 protein

PMID:21643505 PMID:36057382

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105

decreases expression

Gold analog results in decreased expression of NFKB1 mRNA

NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of NFKBID mRNA

NCBI chr 7:30,121,156...30,128,173
Ensembl chr 7:30,121,157...30,128,171

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of NFKBIZ mRNA

NCBI chr16:55,631,740...55,659,018
Ensembl chr16:55,631,738...55,659,262

G

NIPBL cohesin loading factor

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of NIPBL mRNA

NCBI chr15:8,319,308...8,494,799
Ensembl chr15:8,320,101...8,473,947

G

nitric oxide synthase 2, inducible

increases expression

Gold results in increased expression of NOS2 protein

NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080

G

NPL4 homolog, ubiquitin recognition factor

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of NPLOC4 mRNA

NCBI chr11:120,270,624...120,328,526
Ensembl chr11:120,271,196...120,328,534

G

nucleophosmin 1

decreases expression

Gold results in decreased expression of NPM1 mRNA

NCBI chr11:33,102,498...33,114,143
Ensembl chr11:33,102,287...33,113,206

G

NAD(P)H dehydrogenase, quinone 1

multiple interactions
increases expression

[Polyethyleneimine binds to Gold] which results in increased expression of NQO1 mRNA
Gold analog results in increased expression of NQO1 mRNA; Gold results in increased expression of NQO1 mRNA

PMID:28433809 PMID:29705079 PMID:36057382

NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838

G

nuclear receptor subfamily 0, group B, member 2

decreases expression

Gold analog results in decreased expression of NR0B2 mRNA

NCBI chr 4:133,280,687...133,283,997
Ensembl chr 4:133,280,687...133,283,847

G

nuclear receptor subfamily 4, group A, member 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of NR4A1 mRNA

NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676

G

neuronal cell adhesion molecule

increases expression

Gold results in increased expression of NRCAM mRNA

NCBI chr12:44,375,568...44,651,977
Ensembl chr12:44,375,668...44,648,747

G

nuclear receptor interacting protein 1

increases expression

Gold results in increased expression of NRIP1 mRNA

NCBI chr16:76,084,291...76,170,930
Ensembl chr16:76,084,288...76,170,715

G

netrin 4

increases expression

Gold results in increased expression of NTN4 mRNA

NCBI chr10:93,476,911...93,581,834
Ensembl chr10:93,476,543...93,583,069

G

nucleobindin 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of NUCB1 mRNA

NCBI chr 7:45,142,300...45,159,813
Ensembl chr 7:45,139,882...45,159,830

G

nudix hydrolase 1

decreases expression

Gold analog results in decreased expression of NUDT1 mRNA

NCBI chr 5:140,307,375...140,323,892
Ensembl chr 5:140,307,411...140,323,892

G

nudix hydrolase 12

decreases expression

Gold results in decreased expression of NUDT12 mRNA

NCBI chr17:59,307,104...59,320,317
Ensembl chr17:59,306,613...59,320,367

G

nudix hydrolase 13

decreases expression

Gold analog results in decreased expression of NUDT13 mRNA

NCBI chr14:20,344,709...20,367,652
Ensembl chr14:20,344,765...20,367,646

G

nucleoporin 210

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of NUP210 mRNA

NCBI chr 6:90,990,049...91,095,920
Ensembl chr 6:90,990,050...91,093,811

G

ORC ubiquitin ligase 1

decreases expression

Gold results in decreased expression of OBI1 mRNA

NCBI chr14:104,714,970...104,760,148
Ensembl chr14:104,714,972...104,760,081

G

odr4 GPCR localization factor homolog

decreases expression

Gold results in decreased expression of ODR4 mRNA

NCBI chr 1:150,237,056...150,268,831
Ensembl chr 1:150,237,056...150,268,831

G

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of OGDH mRNA

NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642

G

8-oxoguanine DNA-glycosylase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of OGG1 mRNA

NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029

G

olfactory receptor family 52 subfamily N member 20

increases expression

Gold results in increased expression of PNLIPRP3 mRNA

NCBI chr 7:104,319,911...104,320,879
Ensembl chr 7:104,315,960...104,324,155

G

origin recognition complex, subunit 4

decreases expression

Gold results in decreased expression of ORC4 mRNA

NCBI chr 2:48,792,836...48,840,287
Ensembl chr 2:48,792,836...48,840,289

G

amplified in osteosarcoma

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of OS9 mRNA

NCBI chr10:126,928,880...126,957,029
Ensembl chr10:126,931,519...126,957,000

G

oxidative stress induced growth inhibitor 1

increases expression

Gold results in increased expression of OSGIN1 mRNA

NCBI chr 8:120,160,874...120,172,996
Ensembl chr 8:120,160,863...120,172,995

G

prolyl 4-hydroxylase, beta polypeptide

decreases expression

Gold analog results in decreased expression of P4HB protein

NCBI chr11:120,451,124...120,464,079
Ensembl chr11:120,451,124...120,464,079

G

poly (ADP-ribose) polymerase family, member 1

multiple interactions
decreases expression

Organogold Compounds promotes the reaction [Gold binds to PARP1 protein]
Gold analog results in decreased expression of PARP1 mRNA

PMID:21370912 PMID:36057382

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

poly(rC) binding protein 1

decreases expression

Gold analog results in decreased expression of PCBP1 protein

NCBI chr 6:86,501,462...86,503,171
Ensembl chr 6:86,501,474...86,503,303

G

propionyl-Coenzyme A carboxylase, alpha polypeptide

decreases expression

Gold analog results in decreased expression of PCCA mRNA

NCBI chr14:122,721,822...123,127,372
Ensembl chr14:122,771,736...123,128,512

G

polycomb group ring finger 5

decreases expression

Gold results in decreased expression of PCGF5 mRNA

NCBI chr19:36,325,729...36,438,370
Ensembl chr19:36,325,709...36,438,370

G

polycomb group ring finger 6

decreases expression

Gold results in decreased expression of PCGF6 mRNA

NCBI chr19:47,022,056...47,039,379
Ensembl chr19:47,022,056...47,039,345

G

proliferating cell nuclear antigen

decreases expression

Gold analog results in decreased expression of PCNA mRNA

NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234

G

phosphodiesterase 4B, cAMP specific

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PDE4B mRNA

NCBI chr 4:101,944,529...102,464,459
Ensembl chr 4:101,944,740...102,464,456

G

period circadian clock 3

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of PER3 mRNA

NCBI chr 4:151,081,475...151,129,167
Ensembl chr 4:151,088,109...151,129,122

G

phosphatidylinositol glycan anchor biosynthesis, class A

decreases expression

Gold results in decreased expression of PIGA mRNA

NCBI chr X:163,202,814...163,216,912
Ensembl chr X:163,202,783...163,216,912

G

phosphatidylinositol glycan anchor biosynthesis, class F

decreases expression

Gold results in decreased expression of PIGF mRNA

NCBI chr17:87,304,686...87,332,972
Ensembl chr17:87,304,684...87,332,834

G

phosphatidylinositol glycan anchor biosynthesis, class K

decreases expression

Gold results in decreased expression of PIGK mRNA

NCBI chr 3:152,419,718...152,548,705
Ensembl chr 3:152,419,737...152,686,045

G

phosphatidylinositol glycan anchor biosynthesis, class Y-like

decreases expression

Gold results in decreased expression of PIGY mRNA

NCBI chr 9:22,068,142...22,069,651
Ensembl chr 9:22,068,142...22,069,654

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PIK3R1 mRNA

NCBI chr13:101,817,269...101,904,725
Ensembl chr13:101,817,071...101,904,725

G

pyruvate kinase, muscle

decreases expression

Gold analog results in decreased expression of PKM protein

NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658

G

phospholipase A2, group VI

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PLA2G6 mRNA

NCBI chr15:79,170,428...79,212,915
Ensembl chr15:79,170,428...79,212,590

G

pleckstrin homology domain containing, family F (with FYVE domain) member 2

decreases expression

Gold results in decreased expression of PLEKHF2 mRNA

NCBI chr 4:10,988,662...11,007,619
Ensembl chr 4:10,988,662...11,007,927

G

perilipin 3

increases expression

Gold analog results in increased expression of PLIN3 protein

NCBI chr17:56,585,962...56,597,511
Ensembl chr17:56,584,476...56,599,873

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PMAIP1 mRNA

NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636

G

polymerase (DNA directed), kappa

decreases expression

Gold results in decreased expression of POLK mRNA

NCBI chr13:96,617,195...96,679,087
Ensembl chr13:96,617,198...96,679,087

G

polymerase (RNA) II (DNA directed) polypeptide K

decreases expression

Gold results in decreased expression of POLR2K mRNA

NCBI chr15:36,174,156...36,177,158
Ensembl chr15:36,174,156...36,177,156

G

popeye domain cAMP effector 1

increases expression

Gold results in increased expression of POPDC1 mRNA

NCBI chr10:45,211,783...45,248,580
Ensembl chr10:45,211,868...45,248,575

G

popeye domain containing 3

increases expression

Gold results in increased expression of POPDC3 mRNA

NCBI chr10:45,165,401...45,194,546
Ensembl chr10:45,054,194...45,194,548

G

cytochrome p450 oxidoreductase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of POR mRNA

NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180

G

protein phosphatase 1 catalytic subunit beta

decreases expression

Gold results in decreased expression of PPP1CB mRNA

NCBI chr 5:32,616,192...32,651,057
Ensembl chr 5:32,616,187...32,674,777

G

protein phosphatase 2, regulatory subunit A, alpha

decreases expression

Gold analog results in decreased expression of PPP2R1A protein

NCBI chr17:21,165,716...21,186,167
Ensembl chr17:21,165,573...21,186,178

G

protein phosphatase 2, regulatory subunit B', epsilon

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of PPP2R5E mRNA

NCBI chr12:75,496,237...75,643,064
Ensembl chr12:75,497,655...75,643,019

G

peroxiredoxin 1

decreases expression
increases expression

Gold analog results in decreased expression of PRDX1 protein
Gold analog results in increased expression of PRDX1 mRNA

PMID:24780912 PMID:36057382

NCBI chr 4:116,542,796...116,557,196
Ensembl chr 4:116,542,741...116,558,019

G

proline-rich coiled-coil 2A

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PRRC2A mRNA

NCBI chr17:35,368,052...35,384,877
Ensembl chr17:35,368,052...35,383,873

G

phosphoserine aminotransferase 1

decreases expression

Gold analog results in decreased expression of PSAT1 protein

NCBI chr19:15,882,487...15,902,423
Ensembl chr19:15,882,042...15,924,701

G

proteasome (prosome, macropain) 26S subunit, non-ATPase, 14

decreases expression

Gold results in decreased expression of PSMD14 mRNA

NCBI chr 2:61,542,038...61,630,720
Ensembl chr 2:61,542,038...61,630,720

G

polypyrimidine tract binding protein 2

decreases expression

Gold results in decreased expression of PTBP2 mRNA

NCBI chr 3:119,512,390...119,578,296
Ensembl chr 3:119,512,391...119,578,115

G

prostaglandin reductase 1

increases expression

Gold results in increased expression of PTGR1 mRNA

NCBI chr 4:58,965,590...58,987,131
Ensembl chr 4:58,965,439...58,987,119

G

prostaglandin reductase 2

decreases expression

Gold results in decreased expression of PTGR2 mRNA

NCBI chr12:84,332,011...84,362,606
Ensembl chr12:84,332,006...84,362,606

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

[Gold co-treated with Silicon Dioxide] results in increased expression of PTGS2 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of PTGS2 mRNA
Gold results in increased expression of PTGS2 mRNA

PMID:22155353 PMID:28433809

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

protein tyrosine phosphatase receptor type C

increases expression

Gold analog results in increased expression of PTPRC mRNA

NCBI chr 1:137,990,601...138,103,491
Ensembl chr 1:137,990,599...138,103,446

G

6-pyruvoyl-tetrahydropterin synthase

decreases expression

Gold results in decreased expression of PTS mRNA

NCBI chr 9:50,432,917...50,440,017
Ensembl chr 9:50,432,917...50,440,024

G

poliovirus receptor

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of PVR mRNA

NCBI chr 7:19,637,503...19,655,068
Ensembl chr 7:19,637,503...19,655,085

G

RAB11A, member RAS oncogene family

decreases expression

Gold results in decreased expression of RAB11A mRNA

NCBI chr 9:64,622,582...64,645,038
Ensembl chr 9:64,622,581...64,645,040

G

RAB18, member RAS oncogene family

decreases expression

Gold results in decreased expression of RAB18 mRNA

NCBI chr18:6,765,167...6,791,606
Ensembl chr18:6,733,905...6,794,429

G

Rab geranylgeranyl transferase, b subunit

decreases expression

Gold results in decreased expression of RABGGTB mRNA

NCBI chr 3:153,612,926...153,618,603
Ensembl chr 3:153,612,924...153,618,646

G

RAD51 recombinase

decreases expression

Gold analog results in decreased expression of RAD51 mRNA

NCBI chr 2:118,943,295...118,966,554
Ensembl chr 2:118,943,274...118,977,926

G

RAD51 paralog B

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RAD51B mRNA

NCBI chr12:79,344,032...79,895,034
Ensembl chr12:79,344,056...79,861,464

G

retinoic acid induced 14

increases expression

Gold results in increased expression of RAI14 mRNA

NCBI chr15:10,569,057...10,719,353
Ensembl chr15:10,569,055...10,714,710

G

RB1-inducible coiled-coil 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RB1CC1 mRNA

NCBI chr 1:6,284,858...6,346,599
Ensembl chr 1:6,276,421...6,346,872

G

RNA binding motif protein 12

decreases expression

Gold results in decreased expression of RBM12 mRNA

NCBI chr 2:155,933,876...155,953,847
Ensembl chr 2:155,933,878...155,953,898

G

retinol binding protein 1, cellular

increases expression

Gold results in increased expression of RBP1 mRNA

NCBI chr 9:98,305,014...98,328,604
Ensembl chr 9:98,305,014...98,328,628

G

RING CCCH (C3H) domains 1

decreases expression

Gold results in decreased expression of RC3H1 mRNA

NCBI chr 1:160,733,981...160,802,546
Ensembl chr 1:160,733,988...160,802,548

G

radixin

decreases expression

Gold analog results in decreased expression of RDX mRNA

NCBI chr 9:51,958,450...52,000,038
Ensembl chr 9:51,958,473...52,011,763

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

riboflavin kinase

decreases expression

Gold results in decreased expression of RFK mRNA

NCBI chr19:17,371,407...17,378,713
Ensembl chr19:17,371,407...17,378,713

G

ras homolog family member U

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RHOU mRNA

NCBI chr 8:124,380,609...124,390,622
Ensembl chr 8:124,380,668...124,390,623

G

ring finger protein 11

decreases expression

Gold results in decreased expression of RNF11 mRNA

NCBI chr 4:109,310,054...109,333,702
Ensembl chr 4:109,308,295...109,341,925

G

ring finger protein 13

decreases expression

Gold results in decreased expression of RNF13 mRNA

NCBI chr 3:57,643,468...57,742,846
Ensembl chr 3:57,643,483...57,742,654

G

ring finger protein 138

decreases expression

Gold results in decreased expression of RNF138 mRNA

NCBI chr18:21,134,202...21,161,281
Ensembl chr18:21,134,398...21,161,281

G

ring finger protein 149

decreases expression

Gold results in decreased expression of RNF149 mRNA

NCBI chr 1:39,590,375...39,616,885
Ensembl chr 1:39,590,377...39,616,486

G

ring finger protein 2

decreases expression

Gold results in decreased expression of RNF2 mRNA

NCBI chr 1:151,345,159...151,376,562
Ensembl chr 1:151,333,755...151,376,706

G

ring finger protein, transmembrane 1

decreases expression

Gold results in decreased expression of RNFT1 mRNA

NCBI chr11:86,375,483...86,389,833
Ensembl chr11:86,375,483...86,389,851

G

Ro60, Y RNA binding protein

decreases expression

Gold results in decreased expression of RO60 mRNA

NCBI chr 1:143,626,528...143,652,794
Ensembl chr 1:143,626,528...143,652,806

G

retinitis pigmentosa 2 homolog

decreases expression

Gold results in decreased expression of RP2 mRNA

NCBI chr X:20,230,778...20,271,873
Ensembl chr X:20,230,720...20,271,892

G

ribosomal protein S27-like

decreases expression

Gold results in decreased expression of RPS27L mRNA

NCBI chr 9:66,851,906...66,856,804
Ensembl chr 9:66,853,368...66,856,798

G

ribosomal protein S6 kinase, polypeptide 1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased expression of RPS6KB1 protein

NCBI chr11:86,389,695...86,435,711
Ensembl chr11:86,389,697...86,435,631

G

reticulon 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of RTN4 mRNA

NCBI chr11:29,642,898...29,694,414
Ensembl chr11:29,642,947...29,694,331

G

serum amyloid A 1

increases expression
multiple interactions

Gold results in increased expression of SAA1 mRNA
Gold promotes the reaction [SAA1 protein binds to TLR2 protein]

NCBI chr 7:46,389,921...46,392,404
Ensembl chr 7:46,389,921...46,392,404

G

secretion associated Ras related GTPase 1B

decreases expression

Gold results in decreased expression of SAR1B mRNA

NCBI chr11:51,654,490...51,682,780
Ensembl chr11:51,654,514...51,682,752

G

SAP domain containing ribonucleoprotein

decreases expression

Gold results in decreased expression of SARNP mRNA

NCBI chr10:128,657,633...128,713,507
Ensembl chr10:128,653,202...128,713,498

G

short coiled-coil protein

decreases expression

Gold results in decreased expression of SCOC mRNA

NCBI chr 8:84,161,121...84,185,055
Ensembl chr 8:84,156,713...84,185,020

G

sterol carrier protein 2, liver

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of SCP2 mRNA

NCBI chr 4:107,901,027...108,002,168
Ensembl chr 4:107,901,036...108,002,195

G

SEC23 homolog A, COPII coat complex component

decreases expression

Gold results in decreased expression of SEC23A mRNA

NCBI chr12:59,005,170...59,058,803
Ensembl chr12:59,005,169...59,058,803

G

SEC24 homolog A, COPII coat complex component

decreases expression

Gold results in decreased expression of SEC24A mRNA

NCBI chr11:51,583,090...51,649,172
Ensembl chr11:51,583,091...51,654,461

G

sel-1 suppressor of lin-12-like 3 (C. elegans)

increases expression

Gold results in increased expression of SEL1L3 mRNA

NCBI chr 5:53,264,425...53,370,794
Ensembl chr 5:53,264,425...53,371,269

G

selenoprotein T

decreases expression

Gold results in decreased expression of SELENOT mRNA

NCBI chr 3:58,484,057...58,500,965
Ensembl chr 3:58,484,057...58,500,554

G

septin 8

decreases expression

Gold analog results in decreased expression of SEPTIN8 protein

NCBI chr11:53,410,224...53,440,432
Ensembl chr11:53,410,084...53,440,392

G

stress-associated endoplasmic reticulum protein 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of SERP1 mRNA

NCBI chr 3:58,429,390...58,433,305
Ensembl chr 3:58,427,238...58,433,313

G

serine (or cysteine) peptidase inhibitor, clade E, member 1

increases expression

Gold results in increased expression of SERPINE1 mRNA

NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122

G

serine (or cysteine) peptidase inhibitor, clade H, member 1

decreases expression

Gold analog results in decreased expression of SERPINH1 protein

NCBI chr 7:98,994,583...99,002,321
Ensembl chr 7:98,994,583...99,002,446

G

SH3-domain kinase binding protein 1

increases expression

Gold results in increased expression of SH3KBP1 mRNA

NCBI chr X:158,409,888...158,758,916
Ensembl chr X:158,410,268...158,761,065

G

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24

decreases expression

Gold analog results in decreased expression of SLC25A24 protein

NCBI chr 3:109,030,465...109,075,725
Ensembl chr 3:109,030,465...109,075,773

G

SRA stem-loop interacting RNA binding protein

decreases expression

Gold results in decreased expression of SLIRP mRNA

NCBI chr12:87,490,666...87,496,694
Ensembl chr12:87,490,666...87,498,976

G

SNF2 related chromatin remodeling ATPase with DExD box 1

decreases expression

Gold results in decreased expression of SMARCAD1 mRNA

NCBI chr 6:65,019,577...65,093,045
Ensembl chr 6:65,019,567...65,093,045

G

structural maintenance of chromosomes 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SMC4 mRNA

NCBI chr 3:68,912,071...68,941,956
Ensembl chr 3:68,912,071...68,941,956

G

structural maintenance of chromosomes 6

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SMC6 mRNA

NCBI chr12:11,315,887...11,369,786
Ensembl chr12:11,315,887...11,369,786

G

U2 small nuclear ribonucleoprotein B

decreases expression

Gold results in decreased expression of SNRPB2 mRNA

NCBI chr 2:142,904,989...142,913,972
Ensembl chr 2:142,904,959...142,914,773

G

sorting nexin 6

decreases expression

Gold results in decreased expression of SNX6 mRNA

NCBI chr12:54,793,124...54,842,464
Ensembl chr12:54,793,134...54,842,488

G

superoxide dismutase 1, soluble

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SOD1 mRNA

NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217

G

nuclear antigen Sp100

decreases expression

Gold results in decreased expression of SP100 mRNA

NCBI chr 1:85,577,683...85,637,719
Ensembl chr 1:85,577,709...85,637,719

G

trans-acting transcription factor 3

decreases expression

Gold results in decreased expression of SP3 mRNA

NCBI chr 2:72,766,774...72,810,790
Ensembl chr 2:72,766,771...72,810,790

G

spastin

decreases expression

Gold results in decreased expression of SPAST mRNA

NCBI chr17:74,643,805...74,698,110
Ensembl chr17:74,645,982...74,698,110

G

spermatogenesis associated 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of SPATA2 mRNA

NCBI chr 2:167,323,053...167,334,804
Ensembl chr 2:167,323,053...167,334,807

G

sterol regulatory element binding transcription factor 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of SREBF1 mRNA
Gold analog results in decreased expression of SREBF1 mRNA

PMID:28433809 PMID:36057382

NCBI chr11:60,089,910...60,113,407
Ensembl chr11:60,089,915...60,113,407

G

splicing regulatory glutamine/lysine-rich protein 1interacting protein 1

decreases expression

Gold results in decreased expression of SREK1IP1 mRNA

NCBI chr13:104,953,696...104,975,805
Ensembl chr13:104,928,992...104,975,782

G

signal recognition particle 9

decreases expression

Gold results in decreased expression of SRP9 mRNA

NCBI chr 1:181,952,302...181,959,980
Ensembl chr 1:181,952,302...181,959,972

G

serine and arginine-rich splicing factor 10

decreases expression

Gold results in decreased expression of SRSF10 mRNA

NCBI chr 4:135,582,454...135,597,219
Ensembl chr 4:135,583,058...135,597,219

G

serine and arginine-rich splicing factor 3

decreases expression

Gold results in decreased expression of SRSF3 mRNA

NCBI chr17:29,251,634...29,262,346
Ensembl chr17:29,251,602...29,262,347

G

serine and arginine-rich splicing factor 7

decreases expression

Gold results in decreased expression of SRSF7 mRNA

NCBI chr17:80,507,509...80,514,734
Ensembl chr17:80,507,509...80,514,736

G

signal transducer and activator of transcription 1

multiple interactions
increases expression

[Gold co-treated with Silicon Dioxide] results in increased expression of STAT1 mRNA
Gold results in increased expression of STAT1 mRNA

NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024

G

signal transducer and activator of transcription 3

increases expression
multiple interactions

Gold results in increased expression of STAT3 mRNA
[Gold co-treated with Silicon Dioxide] results in increased expression of STAT3 mRNA

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

G

staufen double-stranded RNA binding protein 2

decreases expression

Gold results in decreased expression of STAU2 mRNA

NCBI chr 1:16,299,027...16,591,228
Ensembl chr 1:16,298,898...16,590,336

G

starch binding domain 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of STBD1 mRNA

NCBI chr 5:92,750,910...92,754,438
Ensembl chr 5:92,750,900...92,754,438

G

six transmembrane epithelial antigen of the prostate 1

decreases expression

Gold results in decreased expression of STEAP1 mRNA

NCBI chr 5:5,786,322...5,799,317
Ensembl chr 5:5,786,317...5,799,326

G

serine/threonine kinase 26

decreases expression

Gold results in decreased expression of STK26 mRNA

NCBI chr X:49,930,052...49,981,980
Ensembl chr X:49,929,924...49,981,974

G

succinate-Coenzyme A ligase, ADP-forming, beta subunit

decreases expression

Gold analog results in decreased expression of SUCLA2 mRNA; Gold results in decreased expression of SUCLA2 mRNA

PMID:25523186 PMID:36057382

NCBI chr14:73,790,226...73,833,584
Ensembl chr14:73,762,759...73,833,582

G

synaptotagmin I

decreases expression

Gold analog results in decreased expression of SYT1 mRNA

NCBI chr10:108,333,511...108,846,852
Ensembl chr10:108,333,511...108,846,843

G

synovial apoptosis inhibitor 1, synoviolin

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of SYVN1 mRNA

NCBI chr19:6,096,586...6,103,748
Ensembl chr19:6,096,606...6,103,742

G

tumor-associated calcium signal transducer 2

increases expression

Gold results in increased expression of TACSTD2 mRNA

NCBI chr 6:67,511,043...67,512,806
Ensembl chr 6:67,511,046...67,512,780

G

transcriptional adaptor 1

decreases expression

Gold results in decreased expression of TADA1 mRNA

NCBI chr 1:166,206,736...166,221,190
Ensembl chr 1:166,206,666...166,221,190

G

TATA-box binding protein associated factor 9B

decreases expression

Gold results in decreased expression of TAF9B mRNA

NCBI chr X:105,250,480...105,264,764
Ensembl chr X:105,250,489...105,264,764

G

transgelin

decreases expression

Gold analog results in decreased expression of TAGLN mRNA

NCBI chr 9:45,840,926...45,847,356
Ensembl chr 9:45,840,917...45,847,356

G

transducin (beta)-like 1X-linked receptor 1

decreases expression

Gold results in decreased expression of TBL1XR1 mRNA

NCBI chr 3:22,130,756...22,270,758
Ensembl chr 3:22,130,816...22,270,758

G

transcription elongation factor A (SII) 1

decreases expression

Gold results in decreased expression of TCEA1 mRNA

NCBI chr 1:4,927,917...4,968,132
Ensembl chr 1:4,928,037...4,968,132

G

tryptophan 2,3-dioxygenase

decreases expression

Gold results in decreased expression of TDO2 mRNA

NCBI chr 3:81,865,719...81,883,035
Ensembl chr 3:81,864,397...81,883,509

G

testis expressed 30

decreases expression

Gold results in decreased expression of TEX30 mRNA

NCBI chr 1:44,125,773...44,141,650
Ensembl chr 1:44,125,773...44,141,601

G

transcription factor EC

decreases expression

Gold results in decreased expression of TFEC mRNA

NCBI chr 6:16,830,926...16,898,463
Ensembl chr 6:16,833,372...16,898,440

G

tissue factor pathway inhibitor 2

increases expression

Gold results in increased expression of TFPI2 mRNA

NCBI chr 6:3,962,589...3,988,977
Ensembl chr 6:3,962,595...3,988,919

G

transforming growth factor, beta 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TGFB1 mRNA

NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502

G

THAP domain containing, apoptosis associated protein 1

decreases expression

Gold results in decreased expression of THAP1 mRNA

NCBI chr 8:26,648,197...26,654,179
Ensembl chr 8:26,648,169...26,654,179

G

cytotoxic granule-associated RNA binding protein 1

decreases expression

Gold results in decreased expression of TIA1 mRNA

NCBI chr 6:86,381,001...86,410,387
Ensembl chr 6:86,381,201...86,410,387

G

transketolase

decreases expression

Gold analog results in decreased expression of TKT protein

NCBI chr14:30,271,088...30,296,681
Ensembl chr14:30,270,316...30,296,677

G

tousled-like kinase 1

increases expression

Gold results in increased expression of TLK1 mRNA

NCBI chr 2:70,542,751...70,656,505
Ensembl chr 2:70,542,751...70,656,072

G

toll-like receptor 2

increases expression
multiple interactions

Gold results in increased expression of TLR2 mRNA
Gold promotes the reaction [SAA1 protein binds to TLR2 protein]

NCBI chr 3:83,743,579...83,749,045
Ensembl chr 3:83,743,579...83,749,074

G

transmembrane 4 superfamily member 1

increases expression

Gold results in increased expression of TM4SF1 mRNA

NCBI chr 3:57,193,038...57,295,150
Ensembl chr 3:57,193,032...57,209,409
Ensembl chr 3:57,193,032...57,209,409

G

transmembrane p24 trafficking protein 10

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of TMED10 mRNA

NCBI chr12:85,387,388...85,421,491
Ensembl chr12:85,387,388...85,421,621

G

tumor necrosis factor

increases secretion
multiple interactions

Gold results in increased secretion of TNF protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of TNF protein

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

tumor necrosis factor, alpha-induced protein 3

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of TNFAIP3 mRNA

NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405

G

tumor necrosis factor, alpha-induced protein 8-like 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFAIP8L1 mRNA

NCBI chr17:56,469,439...56,491,249
Ensembl chr17:56,469,477...56,480,955

G

tumor necrosis factor receptor superfamily, member 10b

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFRSF10A mRNA

NCBI chr14:70,004,921...70,021,860
Ensembl chr14:70,004,921...70,021,860

G

tumor necrosis factor receptor superfamily, member 1a

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFRSF1A mRNA

NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447

G

tumor necrosis factor (ligand) superfamily, member 10

decreases expression

Gold analog results in decreased expression of TNFSF10 mRNA

NCBI chr 3:27,371,226...27,393,814
Ensembl chr 3:27,371,177...27,396,576

G

tumor protein, translationally-controlled 1

decreases expression

Gold analog results in decreased expression of TPT1 protein

NCBI chr14:76,082,771...76,085,743
Ensembl chr14:76,082,533...76,085,965

G

tripartite motif-containing 23

decreases expression

Gold results in decreased expression of TRIM23 mRNA

NCBI chr13:104,315,187...104,339,983
Ensembl chr13:104,315,305...104,339,880

G

tRNA methyltransferase 13

decreases expression

Gold results in decreased expression of TRMT13 mRNA

NCBI chr 3:116,365,706...116,408,236
Ensembl chr 3:116,374,742...116,408,236

G

transformation related protein 53

increases expression

Gold analog results in increased expression of TRP53 mRNA

NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699

G

TruB pseudouridine (psi) synthase family member 1

decreases expression

Gold results in decreased expression of TRUB1 mRNA

NCBI chr19:57,441,323...57,479,437
Ensembl chr19:57,441,344...57,479,437

G

tubulin, alpha 1A

decreases expression

Gold analog results in decreased expression of TUBA1A protein

NCBI chr15:98,847,728...98,851,382
Ensembl chr15:98,847,718...98,851,584

G

tubulin, beta 5 class I

decreases expression

Gold analog results in decreased expression of TUBB5 protein

NCBI chr17:36,144,812...36,149,193
Ensembl chr17:36,144,813...36,149,198

G

Tu translation elongation factor, mitochondrial

multiple interactions

Gold analog results in decreased expression of and results in increased phosphorylation of TUFM protein

NCBI chr 7:126,086,445...126,089,903
Ensembl chr 7:126,086,533...126,089,903

G

thioredoxin domain containing 5

multiple interactions

Gold analog results in decreased expression of and results in increased phosphorylation of TXNDC5 protein

NCBI chr13:38,684,242...38,712,800
Ensembl chr13:38,684,055...38,712,800

G

thioredoxin interacting protein

decreases expression

Gold analog results in decreased expression of TXNIP mRNA

NCBI chr 3:96,465,273...96,469,173
Ensembl chr 3:96,465,273...96,469,199

G

thioredoxin reductase 1

decreases activity
increases expression

Gold results in decreased activity of TXNRD1 protein
Gold results in increased expression of TXNRD1 mRNA

PMID:16510263 PMID:20851179 PMID:29705079

NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546

G

thioredoxin reductase 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TXNRD2 mRNA

NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823

G

UDP-N-acteylglucosamine pyrophosphorylase 1-like 1

decreases expression

Gold analog results in decreased expression of UAP1L1 protein

NCBI chr 2:25,251,501...25,255,695
Ensembl chr 2:25,249,901...25,255,694

G

ubiquitin-like modifier activating enzyme 2

decreases expression

Gold results in decreased expression of UBA2 mRNA

NCBI chr 7:33,840,121...33,868,014
Ensembl chr 7:33,840,113...33,869,024

G

ubiquitin-conjugating enzyme E2G 2

decreases expression

Gold analog results in decreased expression of UBE2G2 mRNA

NCBI chr10:77,458,155...77,481,824
Ensembl chr10:77,458,109...77,481,827

G

ubiquitin-conjugating enzyme E2H

increases expression

Gold results in increased expression of UBE2H mRNA

NCBI chr 6:30,211,288...30,304,538
Ensembl chr 6:30,211,288...30,304,538

G

ubiquitin-conjugating enzyme E2N

decreases expression

Gold results in decreased expression of UBE2N mRNA

NCBI chr10:95,351,024...95,381,520
Ensembl chr10:95,351,007...95,381,519

G

ubiquitin-conjugating enzyme E2W (putative)

decreases expression

Gold results in decreased expression of UBE2W mRNA

NCBI chr 1:16,611,012...16,689,676
Ensembl chr 1:16,611,014...16,689,713

G

uncoupling protein 2 (mitochondrial, proton carrier)

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of UCP2 mRNA

NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227

G

UDP glucuronosyltransferase 1 family, polypeptide A1

decreases expression

Gold analog results in decreased expression of UGT1A1 mRNA

NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719

G

UDP glucuronosyltransferase 2 family, polypeptide A1

decreases expression

Gold analog results in decreased expression of UGT2A1 mRNA

NCBI chr 5:87,607,349...87,638,730
Ensembl chr 5:87,607,349...87,638,730

G

UDP glucuronosyltransferase 2 family, polypeptide B38

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of UGT2B38 mRNA

NCBI chr 5:87,557,798...87,572,062
Ensembl chr 5:87,557,801...87,572,062

G

ubiquitin interaction motif containing 1

increases expression
decreases expression

Gold results in increased expression of UIMC1 mRNA
Gold results in decreased expression of UIMC1 mRNA

NCBI chr13:55,175,693...55,248,176
Ensembl chr13:55,175,693...55,248,113

G

uridine phosphorylase 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of UPP2 mRNA

NCBI chr 2:58,456,329...58,685,858
Ensembl chr 2:58,457,310...58,682,983

G

ubiquitin specific peptidase 1

decreases expression

Gold results in decreased expression of USP1 mRNA

NCBI chr 4:98,812,047...98,823,780
Ensembl chr 4:98,812,047...98,823,780

G

ubiquitin specific peptidase 15

decreases expression

Gold results in decreased expression of USP15 mRNA

NCBI chr10:122,940,911...123,032,924
Ensembl chr10:122,940,911...123,032,900

G

ubiquitin specific peptidase 16

decreases expression

Gold results in decreased expression of USP16 mRNA

NCBI chr16:87,251,833...87,280,403
Ensembl chr16:87,251,591...87,280,405

G

ubiquitin specific peptidase 33

decreases expression

Gold results in decreased expression of USP33 mRNA

NCBI chr 3:152,051,797...152,099,254
Ensembl chr 3:152,052,115...152,099,254

G

ubiquitin specific peptidase 5 (isopeptidase T)

decreases expression

Gold analog results in decreased expression of USP5 protein

NCBI chr 6:124,791,982...124,806,404
Ensembl chr 6:124,791,982...124,806,447

G

vinculin

decreases expression

Gold analog results in decreased expression of VCL protein

NCBI chr14:20,979,436...21,083,744
Ensembl chr14:20,979,466...21,083,744

G

vimentin

increases degradation

Gold analog results in increased degradation of VIM protein

NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637

G

WW domain binding protein 4

decreases expression

Gold results in decreased expression of WBP4 mRNA

NCBI chr14:79,697,377...79,718,708
Ensembl chr14:79,697,377...79,718,960

G

WEE 1 homolog 1 (S. pombe)

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of WEE1 mRNA

NCBI chr 7:109,721,266...109,742,506
Ensembl chr 7:109,721,253...109,742,493

G

xeroderma pigmentosum, complementation group A

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of XPA mRNA

NCBI chr 4:46,175,222...46,196,317
Ensembl chr 4:46,155,347...46,196,311

G

xeroderma pigmentosum, complementation group C

decreases expression

Gold analog results in decreased expression of XPC mRNA

NCBI chr 6:91,466,287...91,492,870
Ensembl chr 6:91,466,287...91,492,870

G

X-ray repair complementing defective repair in Chinese hamster cells 5

decreases expression

Gold analog results in decreased expression of XRCC5 mRNA

NCBI chr 1:72,346,576...72,434,112
Ensembl chr 1:72,346,586...72,434,111

G

YOD1 deubiquitinase

decreases expression

Gold results in decreased expression of YOD1 mRNA

NCBI chr 1:130,645,064...130,652,093
Ensembl chr 1:130,645,064...130,652,095

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of YWHAG mRNA

NCBI chr 5:135,937,233...135,963,495
Ensembl chr 5:135,937,263...135,963,470

G

zinc finger and BTB domain containing 21

decreases expression

Gold results in decreased expression of ZBTB21 mRNA

NCBI chr16:97,746,993...97,763,850
Ensembl chr16:97,744,557...97,763,822

G

zinc finger and BTB domain containing 41

decreases expression

Gold results in decreased expression of ZBTB41 mRNA

NCBI chr 1:139,349,916...139,380,743
Ensembl chr 1:139,350,026...139,380,743

G

zinc finger CCCH-type containing 15

decreases expression

Gold results in decreased expression of ZC3H15 mRNA

NCBI chr 2:83,474,922...83,494,961
Ensembl chr 2:83,474,779...83,494,966

G

zinc finger, CCHC domain containing 10

decreases expression

Gold results in decreased expression of ZCCHC10 mRNA

NCBI chr11:53,215,516...53,224,128
Ensembl chr11:53,215,506...53,224,128

G

zinc finger, CCHC domain containing 9

decreases expression

Gold results in decreased expression of ZCCHC9 mRNA

NCBI chr13:91,944,652...91,955,824
Ensembl chr13:91,944,652...91,955,824

G

zinc finger CCHC-type and RNA binding motif 1

decreases expression

Gold results in decreased expression of ZCRB1 mRNA

NCBI chr15:93,283,987...93,296,218
Ensembl chr15:93,283,978...93,296,215

G

zinc finger, DHHC domain containing 17

decreases expression

Gold results in decreased expression of ZDHHC17 mRNA

NCBI chr10:110,777,640...110,848,587
Ensembl chr10:110,777,641...110,846,001

G

zinc finger, DHHC domain containing 20

decreases expression

Gold results in decreased expression of ZDHHC20 mRNA

NCBI chr14:58,070,159...58,128,288
Ensembl chr14:58,070,160...58,127,733

G

zinc finger, AN1-type domain 1

decreases expression

Gold results in decreased expression of ZFAND1 mRNA

NCBI chr 3:10,405,013...10,416,383
Ensembl chr 3:10,405,013...10,416,377

G

zinc finger, AN1-type domain 6

decreases expression

Gold results in decreased expression of ZFAND6 mRNA

NCBI chr 7:84,264,253...84,339,224
Ensembl chr 7:84,262,974...84,339,167

G

zinc finger protein 277

decreases expression

Gold results in decreased expression of ZNF277 mRNA

NCBI chr12:40,365,045...40,495,789
Ensembl chr12:40,365,045...40,495,901

G

zinc finger protein 422

decreases expression

Gold results in decreased expression of ZNF22 mRNA

NCBI chr 6:116,600,977...116,605,960
Ensembl chr 6:116,600,977...116,605,960

G

zinc finger, FYVE domain containing 16

decreases expression

Gold results in decreased expression of ZFYVE16 mRNA

NCBI chr13:92,624,257...92,667,318
Ensembl chr13:92,623,616...92,667,376

G

zinc metallopeptidase, STE24

decreases expression

Gold results in decreased expression of ZMPSTE24 mRNA

NCBI chr 4:120,916,434...120,955,452
Ensembl chr 4:120,916,434...120,955,438

G

zinc finger, RAN-binding domain containing 2

decreases expression

Gold results in decreased expression of ZRANB2 mRNA

NCBI chr 3:157,239,749...157,254,029
Ensembl chr 3:157,239,797...157,254,047

G

zinc finger containing ubiquitin peptidase 1

decreases expression

Gold results in decreased expression of ZUP1 mRNA

NCBI chr10:33,795,138...33,827,316
Ensembl chr10:33,795,138...33,827,265

auranofin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

thymoma viral proto-oncogene 1

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of AKT1 protein]

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

albumin

affects binding

Auranofin analog binds to ALB protein

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

BCL2-antagonist/killer 1

multiple interactions
increases response to substance

[BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAK1 results in increased susceptibility to Auranofin

PMID:18789312 PMID:21172426

NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983

G

BCL2-associated X protein

multiple interactions
increases response to substance

[BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAX results in increased susceptibility to Auranofin

PMID:18789312 PMID:21172426

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

B cell leukemia/lymphoma 2

multiple interactions

BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein]

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

caspase 3

multiple interactions
increases activity

Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]; Auranofin results in decreased expression of and results in increased cleavage of CASP3 protein; BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]

PMID:15159275 PMID:15191400 PMID:18789312 PMID:20542334 PMID:21699084

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 8

multiple interactions

Auranofin results in decreased expression of and results in increased cleavage of CASP8 protein

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions

Auranofin results in decreased expression of and results in increased cleavage of CASP9 protein

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

cyclin dependent kinase inhibitor 1A

increases expression

Auranofin results in increased expression of CDKN1A protein

NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701

G

CCAAT/enhancer binding protein epsilon

multiple interactions

[Auranofin co-treated with Tretinoin] results in increased expression of CEBPE protein

NCBI chr14:54,947,823...54,949,604
Ensembl chr14:54,947,817...54,949,631

G

conserved helix-loop-helix ubiquitous kinase

multiple interactions

Auranofin inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CHUK protein]; Auranofin inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]
Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]

NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919

G

deiodinase, iodothyronine, type I

decreases activity

Auranofin results in decreased activity of DIO1 protein

NCBI chr 4:107,148,662...107,164,365
Ensembl chr 4:107,148,662...107,164,366

G

epidermal growth factor

multiple interactions

Auranofin promotes the reaction [arsenite results in increased expression of and results in increased secretion of EGF protein]

NCBI chr 3:129,471,223...129,548,971
Ensembl chr 3:129,471,214...129,548,965

G

glutathione peroxidase 1

multiple interactions
increases expression

[Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Auranofin results in increased expression of GPX1 protein]; Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein]

NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542

G

glutathione reductase

multiple interactions

Auranofin promotes the reaction [arsenite results in increased activity of GSR protein]

NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191

G

histocompatibility 2, class II antigen A, alpha

increases response to substance

HLA-DQA1 gene polymorphism results in increased susceptibility to Auranofin

NCBI chr17:34,501,718...34,506,797
Ensembl chr17:34,501,718...34,506,797

G

histocompatibility 2, class II antigen E beta

increases response to substance

HLA-DRB1 gene polymorphism results in increased susceptibility to Auranofin

NCBI chr17:34,524,841...34,535,648
Ensembl chr17:34,524,841...34,535,648

G

heme oxygenase 1

increases expression

Auranofin results in increased expression of HMOX1 mRNA
Auranofin results in increased expression of HMOX1 mRNA; Auranofin results in increased expression of HMOX1 protein

PMID:22008538 PMID:23942037

NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217

G

interleukin 1 beta

multiple interactions

Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]

NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059

G

interleukin 6

multiple interactions

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein

NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979

G

interleukin 6 signal transducer

multiple interactions

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein

NCBI chr13:112,600,604...112,643,394
Ensembl chr13:112,600,604...112,646,620

G

interleukin-1 receptor-associated kinase 1

multiple interactions

Auranofin inhibits the reaction [lipopolysaccharide A results in increased degradation of IRAK1 protein]

NCBI chr X:73,057,520...73,067,527
Ensembl chr X:73,057,520...73,067,524

G

interferon regulatory factor 3

multiple interactions

Auranofin inhibits the reaction [lipopolysaccharide A results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [lipopolysaccharide A results in increased phosphorylation of IRF3 protein]; Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein]

NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272

G

integrin alpha M

multiple interactions

[Auranofin co-treated with Tretinoin] results in increased expression of ITGAM protein

NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663

G

Janus kinase 2

multiple interactions

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein

NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480

G

mitogen-activated protein kinase 1

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK1 protein]

NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317

G

mitogen-activated protein kinase 3

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK3 protein]

NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991

G

mitogen-activated protein kinase 8

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK8 protein]

NCBI chr14:33,099,855...33,169,213
Ensembl chr14:33,099,855...33,169,115

G

myeloid cell leukemia sequence 1

multiple interactions
decreases expression

[Auranofin co-treated with SN50 peptide] results in decreased expression of MCL1 protein
Auranofin results in decreased expression of MCL1 protein

NCBI chr 3:95,564,017...95,583,553
Ensembl chr 3:95,566,099...95,570,487

G

nuclear factor, erythroid derived 2, like 2

multiple interactions

Auranofin promotes the reaction [arsenite results in increased expression of NFE2L2 protein]

NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha

multiple interactions

Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]

NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432

G

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

multiple interactions

Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]

NCBI chr 7:28,457,676...28,466,069
Ensembl chr 7:28,457,676...28,466,937

G

poly (ADP-ribose) polymerase family, member 1

decreases activity
increases cleavage

Auranofin results in decreased activity of PARP1 protein
Auranofin results in increased cleavage of PARP1 protein

PMID:15159275 PMID:21370912

NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819

G

peptidylprolyl isomerase F (cyclophilin F)

increases oxidation
multiple interactions

Auranofin results in increased oxidation of PPIF protein
Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PPIF protein]

NCBI chr14:25,693,998...25,700,892
Ensembl chr14:25,694,578...25,700,892

G

peroxiredoxin 3

increases oxidation
multiple interactions

Auranofin results in increased oxidation of PRDX3 protein
Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PRDX3 protein]
Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of PRDX3 protein]

PMID:18789312 PMID:21355852 PMID:26975474

NCBI chr19:60,852,504...60,862,976
Ensembl chr19:60,852,489...60,862,994

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[lipopolysaccharide A co-treated with Auranofin] results in decreased expression of PTGS2 protein
Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]

PMID:10594346 PMID:17034761

NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978

G

RB transcriptional corepressor 1

decreases phosphorylation

Auranofin results in decreased phosphorylation of RB1 protein

NCBI chr14:73,430,298...73,563,446
Ensembl chr14:73,421,113...73,563,262

G

RNA binding motif, single stranded interacting protein

affects response to substance

RBMS3 protein affects the susceptibility to Auranofin

NCBI chr 9:116,401,814...117,869,900
Ensembl chr 9:116,401,814...117,701,749

G

v-rel reticuloendotheliosis viral oncogene homolog A (avian)

multiple interactions

Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein]; Auranofin promotes the reaction [arsenite results in increased phosphorylation of RELA protein]

PMID:10594346 PMID:36343453

NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158

G

solute carrier family 22 (organic cation transporter), member 2

multiple interactions

Auranofin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375

G

signal transducer and activator of transcription 3

decreases expression
multiple interactions

Auranofin results in decreased expression of STAT3 protein modified form
[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein

NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366

G

TANK-binding kinase 1

multiple interactions

Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]

NCBI chr10:121,382,360...121,422,699
Ensembl chr10:121,382,360...121,422,692

G

transforming growth factor alpha

multiple interactions

Auranofin promotes the reaction [arsenite results in increased expression of and results in increased secretion of TGFA protein]

NCBI chr 6:86,172,020...86,252,726
Ensembl chr 6:86,172,205...86,252,701

G

TIR domain containing adaptor molecule 1

multiple interactions

Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein]

NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786

G

toll-like receptor 4

multiple interactions

Auranofin inhibits the reaction [lipopolysaccharide A promotes the reaction [TLR4 protein binds to TLR4 protein]]

NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521

G

tumor necrosis factor

multiple interactions

Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]
Auranofin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

PMID:10820281 PMID:18789312

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

G

thioredoxin 1

increases oxidation
multiple interactions

Auranofin results in increased oxidation of TXN protein
Auranofin inhibits the reaction [arsenite results in increased expression of TXN protein]

PMID:26975474 PMID:36343453

NCBI chr 4:57,943,373...57,956,411
Ensembl chr 4:57,943,373...57,956,411

G

thioredoxin 2

increases oxidation
multiple interactions

Auranofin results in increased oxidation of TXN2 protein
Cyclosporine promotes the reaction [Auranofin results in increased oxidation of TXN2 protein]

NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206

G

thioredoxin reductase 1

multiple interactions
decreases activity
increases oxidation
increases expression

Auranofin inhibits the reaction [arsenite results in increased expression of and results in increased activity of TXNRD1 protein]; Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]; Auranofin promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]; potassium tellurate(IV) promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]; Sodium Selenite promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]
Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]
Auranofin results in decreased activity of TXNRD1 protein
Auranofin results in increased expression of TXNRD1 mRNA

PMID:16510263 PMID:18405881 PMID:18789312 PMID:19486940 PMID:20457604 More...

NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546

G

thioredoxin reductase 2

multiple interactions
decreases activity

Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD2 protein]; Auranofin promotes the reaction [Sodium Selenite results in decreased expression of TXNRD2 mRNA]
Auranofin results in decreased activity of TXNRD2 protein

PMID:15458826 PMID:19486940 PMID:21172426 PMID:21355852

NCBI chr16:18,245,167...18,297,823
Ensembl chr16:18,245,134...18,297,823

gold nanoparticle

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tumor necrosis factor

decreases secretion

Topical GNP decreases secretion of Tnf protein in aqeous humor

RGD

NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983

gold(0)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RIKEN cDNA 4931406C07 gene

decreases expression

Gold results in decreased expression of C11ORF54 mRNA

NCBI chr 9:15,194,633...15,217,836
Ensembl chr 9:15,194,633...15,217,744

G

aminoadipate-semialdehyde synthase

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of AASS mRNA
Gold analog results in decreased expression of AASS mRNA

PMID:28433809 PMID:36057382

NCBI chr 6:23,072,172...23,132,985
Ensembl chr 6:23,072,172...23,132,985

G

ATP-binding cassette, sub-family B member 1A

increases expression

Gold analog results in increased expression of ABCB1 mRNA

NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575

G

ATP-binding cassette, sub-family B member 4

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCB4 mRNA
Gold analog results in decreased expression of ABCB4 mRNA

PMID:28433809 PMID:36057382

NCBI chr 5:8,943,614...9,009,226
Ensembl chr 5:8,943,717...9,009,231

G

ATP-binding cassette, sub-family C member 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCC1 mRNA

NCBI chr16:14,179,317...14,292,743
Ensembl chr16:14,179,422...14,293,601

G

ATP-binding cassette, sub-family member 2

increases expression

Gold analog results in increased expression of ABCC2 mRNA

NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179

G

c-abl oncogene 1, non-receptor tyrosine kinase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ABL1 mRNA

NCBI chr 2:31,578,256...31,697,105
Ensembl chr 2:31,578,388...31,694,239

G

acetyl-Coenzyme A acyltransferase 1B

decreases expression

Gold analog results in decreased expression of ACAA1 mRNA

NCBI chr 9:118,977,111...118,986,149
Ensembl chr 9:118,977,091...118,986,161

G

acetyl-Coenzyme A carboxylase alpha

decreases expression

Gold analog results in decreased expression of ACACA mRNA

NCBI chr11:84,020,461...84,292,477
Ensembl chr11:84,020,498...84,292,477

G

acyl-Coenzyme A dehydrogenase family, member 11

decreases expression

Gold analog results in decreased expression of ACAD11 mRNA

NCBI chr 9:103,940,923...104,004,855
Ensembl chr 9:103,940,576...104,004,924

G

acyl-Coenzyme A dehydrogenase, medium chain

decreases expression

Gold analog results in decreased expression of ACADM mRNA

NCBI chr 3:153,627,990...153,650,280
Ensembl chr 3:153,627,994...153,650,269

G

acyl-Coenzyme A dehydrogenase, short chain

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADS mRNA

NCBI chr 5:115,248,358...115,257,405
Ensembl chr 5:115,248,358...115,257,405

G

acyl-Coenzyme A dehydrogenase, very long chain

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADVL mRNA

NCBI chr11:69,901,009...69,906,254
Ensembl chr11:69,901,009...69,906,237

G

acyl-coenzyme A amino acid N-acyltransferase 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ACNAT2 mRNA

NCBI chr 4:49,374,458...49,408,151
Ensembl chr 4:49,379,840...49,408,151

G

aconitase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of ACO1 mRNA

NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338

G

aconitase 2, mitochondrial

decreases expression
multiple interactions

Gold analog results in decreased expression of ACO2 protein
[Polyethyleneimine binds to Gold] which results in increased expression of ACO2 mRNA

PMID:24780912 PMID:28433809

NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334

G

acyl-Coenzyme A oxidase 1, palmitoyl

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ACOX1 mRNA

NCBI chr11:116,062,714...116,089,605
Ensembl chr11:116,062,714...116,089,871

G

acyl-Coenzyme A oxidase 2, branched chain

decreases expression

Gold analog results in decreased expression of ACOX2 mRNA

NCBI chr14:14,210,406...14,244,262
Ensembl chr14:14,210,420...14,244,262

G

acid phosphatase 1, soluble

decreases expression

Gold results in decreased expression of ACP1 mRNA

NCBI chr12:30,943,325...30,961,616
Ensembl chr12:30,943,325...30,961,588

G

activin A receptor, type IC

decreases expression

Gold results in decreased expression of ACVR1C mRNA

NCBI chr 2:58,157,465...58,247,909
Ensembl chr 2:58,157,465...58,247,907

G

a disintegrin and metallopeptidase domain 28

increases expression

Gold results in increased expression of ADAM28 mRNA

NCBI chr14:68,842,447...68,893,338
Ensembl chr14:68,843,476...68,893,291

G

alcohol dehydrogenase 5 (class III), chi polypeptide

decreases expression

Gold results in decreased expression of ADH5 mRNA

NCBI chr 3:138,142,961...138,161,260
Ensembl chr 3:138,148,854...138,161,260

G

adiponectin receptor 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ADIPOR2 mRNA

NCBI chr 6:119,330,111...119,394,489
Ensembl chr 6:119,330,111...119,394,665

G

adrenergic receptor, alpha 1b

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRA1B mRNA

NCBI chr11:43,665,432...43,792,076
Ensembl chr11:43,665,433...43,792,037

G

adrenergic receptor, beta 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRB2 mRNA

NCBI chr18:62,310,784...62,313,052
Ensembl chr18:62,310,887...62,313,030

G

alpha-2-HS-glycoprotein

decreases expression

Gold analog results in decreased expression of AHSG mRNA

NCBI chr16:22,710,793...22,718,193
Ensembl chr16:22,710,027...22,718,199

G

apoptosis-inducing factor, mitochondrion-associated 1

increases expression

Gold results in increased expression of AIFM1 protein

NCBI chr X:47,563,821...47,602,440
Ensembl chr X:47,563,821...47,602,440

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

decreases expression

Gold results in decreased expression of AIMP1 mRNA

NCBI chr 3:132,366,259...132,390,151
Ensembl chr 3:132,366,242...132,390,131

G

adenylate kinase 3

decreases expression

Gold results in decreased expression of AK3 mRNA

NCBI chr19:28,968,715...29,026,122
Ensembl chr19:28,998,233...29,025,361

G

A kinase anchor protein 13

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of AKAP13 mRNA

NCBI chr 7:75,105,271...75,404,357
Ensembl chr 7:75,105,282...75,404,357

G

aldo-keto reductase family 1, member B10

increases expression

Gold results in increased expression of AKR1B10 mRNA

NCBI chr 6:34,361,182...34,373,884
Ensembl chr 6:34,361,153...34,373,885

G

aldo-keto reductase family 1, member C18

increases expression

Gold results in increased expression of AKR1C3 mRNA

NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653

G

aldo-keto reductase family 1, member C21

increases expression

Gold results in increased expression of AKR1C2 mRNA

NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540

G

thymoma viral proto-oncogene 1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of AKT1 protein

NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318

G

albumin

multiple interactions
increases expression

ALB protein results in increased uptake of [Polyethylene Glycols binds to Gold]; ALB protein results in increased uptake of [Polyethyleneimine binds to Gold]; ALB protein results in increased uptake of [Thioctic Acid binds to Gold]
Gold analog results in increased expression of ALB mRNA

PMID:28433809 PMID:36057382

NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461

G

annexin A5

increases expression

Gold analog results in increased expression of ANXA5 protein

NCBI chr 3:36,503,072...36,530,036
Ensembl chr 3:36,503,072...36,530,043

G

apoptotic peptidase activating factor 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of APAF1 mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein
Gold analog results in decreased expression of APAF1 mRNA

PMID:27470402 PMID:28433809 PMID:36057382

NCBI chr10:90,825,173...90,918,688
Ensembl chr10:90,825,173...90,918,632

G

apurinic/apyrimidinic endonuclease 1

decreases expression

Gold analog results in decreased expression of APEX1 mRNA

NCBI chr14:51,162,406...51,164,645
Ensembl chr14:51,162,425...51,164,596

G

apolipoprotein A-IV

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of APOA4 mRNA

NCBI chr 9:46,152,142...46,154,756
Ensembl chr 9:46,151,994...46,154,757

G

adenine phosphoribosyl transferase

decreases expression

Gold analog results in decreased expression of APRT protein

NCBI chr 8:123,301,376...123,303,646
Ensembl chr 8:123,301,374...123,303,648

G

aquaporin 4

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of AQP4 mRNA

NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039

G

ADP-ribosylation factor-like 1

decreases expression

Gold results in decreased expression of ARL1 mRNA

NCBI chr10:88,566,720...88,579,956
Ensembl chr10:88,566,720...88,579,956

G

ADP-ribosylation factor-like 5B

decreases expression

Gold results in decreased expression of ARL5B mRNA

NCBI chr 2:15,060,066...15,087,267
Ensembl chr 2:15,054,206...15,087,267

G

arylsulfatase G

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ARSG mRNA

NCBI chr11:109,364,159...109,464,156
Ensembl chr11:109,364,200...109,464,156

G

N-acylsphingosine amidohydrolase 1

decreases expression

Gold analog results in decreased expression of ASAH1 mRNA

NCBI chr 8:41,793,683...41,850,681
Ensembl chr 8:41,793,234...41,827,810

G

activating transcription factor 1

decreases expression

Gold results in decreased expression of ATF1 mRNA

NCBI chr15:100,125,729...100,159,129
Ensembl chr15:100,125,700...100,159,125

G

activating transcription factor 4

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ATF4 mRNA

NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742

G

activating transcription factor 6

increases cleavage

Gold analog results in increased cleavage of ATF6 protein

NCBI chr 1:170,532,026...170,696,414
Ensembl chr 1:170,532,243...170,695,340

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

decreases expression

Gold analog results in decreased expression of ATIC protein

NCBI chr 1:71,596,315...71,618,562
Ensembl chr 1:71,596,309...71,618,790

G

atlastin GTPase 2

decreases expression

Gold results in decreased expression of ATL2 mRNA

NCBI chr17:80,155,819...80,203,633
Ensembl chr17:80,155,819...80,203,552

G

ataxia telangiectasia mutated

decreases expression

Gold analog results in decreased expression of ATM mRNA

NCBI chr 9:53,348,422...53,448,125
Ensembl chr 9:53,350,449...53,448,040

G

ATPase, Ca++ transporting, plasma membrane 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ATP2B1 mRNA

NCBI chr10:98,750,243...98,862,005
Ensembl chr10:98,750,268...98,862,005

G

ATP synthase F1 subunit beta

multiple interactions

Gold analog results in increased expression of and results in decreased phosphorylation of ATP5F1B protein

NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260

G

ATPase, H+ transporting, lysosomal V1 subunit G2

decreases expression

Gold analog results in decreased expression of ATP6V1G2 mRNA

NCBI chr17:35,453,910...35,457,743
Ensembl chr17:35,452,636...35,457,743

G

ataxia telangiectasia and Rad3 related

decreases expression

Gold analog results in decreased expression of ATR mRNA

NCBI chr 9:95,739,655...95,834,813
Ensembl chr 9:95,739,650...95,833,834

G

beta-site APP cleaving enzyme 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BACE1 mRNA

NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697

G

BCL2-associated agonist of cell death

multiple interactions

[Quercetin analog co-treated with Gold analog] results in increased expression of BAD protein

NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267

G

brain-specific angiogenesis inhibitor 1-associated protein 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of BAIAP2 mRNA

NCBI chr11:119,833,762...119,897,608
Ensembl chr11:119,833,589...119,897,608

G

BCL2-antagonist/killer 1

increases expression

Gold results in increased expression of BAK1 mRNA

NCBI chr17:27,238,786...27,247,601
Ensembl chr17:27,238,784...27,247,983

G

BCL2-associated X protein

multiple interactions
increases expression

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein; [Gold analog co-treated with Platinum] results in increased expression of BAX mRNA; [Polyethyleneimine binds to Gold] which results in decreased expression of BAX mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of BAX protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of BAX protein
Gold results in increased expression of BAX mRNA

PMID:21621595 PMID:22178767 PMID:25846798 PMID:27470402 PMID:27836789 More...

NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322

G

BCAS2 pre-mRNA processing factor

decreases expression

Gold results in decreased expression of BCAS2 mRNA

NCBI chr 3:103,078,971...103,086,479
Ensembl chr 3:103,078,971...103,086,482

G

B cell leukemia/lymphoma 2

multiple interactions

[Gold analog co-treated with Platinum] results in decreased expression of BCL2 mRNA; [Quercetin analog co-treated with Gold analog] results in decreased expression of BCL2 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in decreased expression of BCL2 protein

PMID:25846798 PMID:27470402 PMID:27836789

NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004

G

BCL2-like 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of BCL2L1 mRNA

NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648

G

BCL2 like 11

decreases expression

Gold analog results in decreased expression of BCL2L11 mRNA

NCBI chr 2:127,967,958...128,004,467
Ensembl chr 2:127,967,958...128,004,467

G

baculoviral IAP repeat-containing 2

decreases expression

Gold results in decreased expression of BIRC2 mRNA

NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065

G

baculoviral IAP repeat-containing 3

decreases expression

Gold analog results in decreased expression of BIRC3 mRNA; Gold results in decreased expression of BIRC3 mRNA

PMID:25523186 PMID:36057382

NCBI chr 9:7,848,698...7,873,199
Ensembl chr 9:7,848,700...7,873,187

G

basic helix-loop-helix ARNT like 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BMAL1 mRNA

NCBI chr 7:112,777,820...112,913,333
Ensembl chr 7:112,806,672...112,913,333

G

Bmi1 polycomb ring finger oncogene

decreases expression

Gold results in decreased expression of BMI1 mRNA

NCBI chr 2:18,681,953...18,691,440
Ensembl chr 2:18,681,829...18,691,440

G

breast cancer 1, early onset

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA1 mRNA
Gold analog results in decreased expression of BRCA1 mRNA

PMID:28433809 PMID:36057382

NCBI chr11:101,379,587...101,442,808
Ensembl chr11:101,379,590...101,442,781

G

breast cancer 2, early onset

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA2 mRNA
Gold analog results in decreased expression of BRCA2 mRNA

PMID:28433809 PMID:36057382

NCBI chr 5:150,445,759...150,493,612
Ensembl chr 5:150,446,095...150,493,794

G

C1D nuclear receptor co-repressor

decreases expression

Gold results in decreased expression of C1D mRNA

NCBI chr11:17,207,547...17,219,176
Ensembl chr11:17,207,579...17,219,176

G

complement component 3

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of C3 mRNA

NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136

G

complement component 9

decreases expression

Gold analog results in decreased expression of C9 mRNA

NCBI chr15:6,474,827...6,528,306
Ensembl chr15:6,474,808...6,528,232

G

capping actin protein of muscle Z-line subunit alpha 2

decreases expression

Gold results in decreased expression of CAPZA2 mRNA

NCBI chr 6:17,637,009...17,666,971
Ensembl chr 6:17,636,233...17,666,971

G

carbonic anhydrase 13

decreases expression

Gold results in decreased expression of CA13 mRNA

NCBI chr 3:14,706,787...14,728,062
Ensembl chr 3:14,706,787...14,728,062

G

caspase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of CASP1 mRNA

NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290

G

caspase 3

multiple interactions
increases activity
increases cleavage
increases expression

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP3 mRNA; [Polyethyleneimine binds to Gold] which results in increased expression of CASP3 mRNA; [Quercetin analog co-treated with Gold analog] results in increased cleavage of CASP3 protein; [Quercetin analog co-treated with Gold analog] results in increased expression of and results in increased activity of CASP3 protein; Dexamethasone promotes the reaction [Gold results in increased activity of CASP3 protein]; Etoposide promotes the reaction [Gold results in increased activity of CASP3 protein]
Gold analog results in increased cleavage of CASP3 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP3 protein
Gold results in increased expression of CASP3 mRNA

PMID:19760634 PMID:21621595 PMID:22178767 PMID:25846798 PMID:26551149 More...

NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724

G

caspase 4, apoptosis-related cysteine peptidase

increases cleavage

Gold analog results in increased cleavage of CASP4 protein

NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783

G

caspase 7

increases cleavage

Gold analog results in increased cleavage of CASP7 protein

NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776

G

caspase 8

increases expression
decreases expression

Gold results in increased expression of CASP8 mRNA
Gold analog results in decreased expression of CASP8 mRNA

PMID:22178767 PMID:36057382

NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662

G

caspase 9

multiple interactions
increases cleavage

[Gold analog co-treated with Platinum] results in increased activity of CASP9 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP9 mRNA
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP9 protein
Gold analog results in increased cleavage of CASP9 protein

PMID:25846798 PMID:26551149 PMID:27836789

NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287

G

catalase

multiple interactions

[Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]

NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505

G

chromobox 3

decreases expression

Gold results in decreased expression of CBX3 mRNA

NCBI chr 6:51,447,596...51,460,684
Ensembl chr 6:51,447,340...51,460,684

G

C-C motif chemokine ligand 2

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL2 protein
Gold results in increased secretion of CCL2 protein

NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279

G

C-C motif chemokine ligand 5

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL5 protein
Gold results in increased secretion of CCL5 protein

NCBI chr11:83,416,604...83,421,344
Ensembl chr11:83,416,604...83,421,344

G

C-C motif chemokine ligand 7

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL7 protein
Gold results in increased secretion of CCL7 protein

NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351

G

cyclin D1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased expression of CCND1 protein

NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662

G

chaperonin containing TCP1 subunit 5

decreases expression

Gold analog results in decreased expression of CCT5 protein

NCBI chr15:31,590,946...31,601,992
Ensembl chr15:31,590,946...31,601,950

G

CD19 antigen

increases expression

Gold analog results in increased expression of CD19 mRNA

NCBI chr 7:126,007,620...126,016,401
Ensembl chr 7:126,007,622...126,014,061

G

CD36 molecule

decreases expression

Gold analog results in decreased expression of CD36 mRNA

NCBI chr 5:17,986,680...18,093,828
Ensembl chr 5:17,986,688...18,093,799

G

CD40 antigen

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CD40 mRNA

NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868

G

CD86 antigen

decreases expression

Gold analog results in decreased expression of CD86 mRNA

NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443

G

cytidine deaminase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CDA mRNA

NCBI chr 4:138,065,839...138,095,623
Ensembl chr 4:138,065,735...138,095,303

G

cyclin dependent kinase 1

decreases expression
increases expression

Gold results in decreased expression of CDK1 mRNA
Gold results in increased expression of CDK1 mRNA

PMID:25523186 PMID:29705079

NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768

G

cyclin dependent kinase 7

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CDK7 mRNA

NCBI chr13:100,833,532...100,867,454
Ensembl chr13:100,839,139...100,867,447

G

cyclin dependent kinase inhibitor 1B

multiple interactions

[Gold binds to Dimethyldithiocarbamate] which results in increased expression of CDKN1B protein

NCBI chr 6:134,897,364...134,902,488
Ensembl chr 6:134,897,364...134,902,476

G

CDKN2A interacting protein

decreases expression

Gold results in decreased expression of CDKN2AIP mRNA

NCBI chr 8:48,162,379...48,166,966
Ensembl chr 8:48,162,379...48,166,967

G

cell growth regulator with ring finger domain 1

decreases expression

Gold results in decreased expression of CGRRF1 mRNA

NCBI chr14:47,069,591...47,091,655
Ensembl chr14:47,069,582...47,091,650

G

checkpoint kinase 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA
Gold analog results in decreased expression of CHEK1 mRNA

PMID:28433809 PMID:36057382

NCBI chr 9:36,619,935...36,637,897
Ensembl chr 9:36,619,778...36,638,361

G

checkpoint kinase 2

decreases expression

Gold analog results in decreased expression of CHEK2 mRNA

NCBI chr 5:110,987,668...111,022,006
Ensembl chr 5:110,987,845...111,022,011

G

cysteine and histidine rich domain containing 1

decreases expression

Gold results in decreased expression of CHORDC1 mRNA

NCBI chr 9:18,203,563...18,225,296
Ensembl chr 9:18,203,421...18,228,738

G

CDGSH iron sulfur domain 1

decreases expression

Gold results in decreased expression of CISD1 mRNA

NCBI chr10:71,166,324...71,180,679
Ensembl chr10:71,166,310...71,180,784

G

claudin 12

decreases expression

Gold results in decreased expression of CLDN12 mRNA

NCBI chr 5:5,555,109...5,564,953
Ensembl chr 5:5,539,537...5,564,958

G

cellular nucleic acid binding protein

decreases expression

Gold results in decreased expression of CNBP mRNA

NCBI chr 6:87,819,597...87,828,088
Ensembl chr 6:87,819,597...87,828,088

G

CCR4-NOT transcription complex, subunit 7

decreases expression

Gold results in decreased expression of CNOT7 mRNA

NCBI chr 8:40,945,579...40,968,888
Ensembl chr 8:40,945,581...40,968,888

G

collagen, type I, alpha 1

increases expression

Gold analog results in increased expression of COL1A1 protein

NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868

G

collagen, type I, alpha 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL1A2 mRNA

NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544

G

collagen, type III, alpha 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL3A1 mRNA

NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866

G

COMM domain containing 8

decreases expression

Gold results in decreased expression of COMMD8 mRNA

NCBI chr 5:72,313,919...72,325,532
Ensembl chr 5:72,313,918...72,325,532

G

cytochrome c oxidase assembly protein 11, copper chaperone

decreases expression

Gold results in decreased expression of COX11 mRNA

NCBI chr11:90,529,010...90,536,803
Ensembl chr11:90,528,999...90,535,757

G

cytochrome c oxidase assembly protein 17, copper chaperone

decreases expression

Gold results in decreased expression of COX17 mRNA

NCBI chr16:38,167,332...38,173,125
Ensembl chr16:38,167,353...38,182,659

G

carnitine palmitoyltransferase 1a, liver

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT1A mRNA

NCBI chr19:3,372,328...3,435,735
Ensembl chr19:3,372,334...3,435,733

G

carnitine palmitoyltransferase 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT2 mRNA

NCBI chr 4:107,761,179...107,780,786
Ensembl chr 4:107,761,178...107,780,807

G

carnitine O-octanoyltransferase

decreases expression

Gold analog results in decreased expression of CROT mRNA

NCBI chr 5:9,016,033...9,047,926
Ensembl chr 5:9,016,033...9,047,324

G

colony stimulating factor 2 (granulocyte-macrophage)

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF2 protein
Gold results in increased secretion of CSF2 protein

NCBI chr11:54,138,096...54,140,725
Ensembl chr11:54,138,097...54,140,493

G

colony stimulating factor 3 (granulocyte)

increases secretion
multiple interactions

Gold results in increased secretion of CSF3 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF3 protein

NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455

G

CCCTC-binding factor

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CTCF mRNA

NCBI chr 8:106,351,135...106,409,554
Ensembl chr 8:106,363,200...106,409,554

G

cut-like homeobox 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CUX1 mRNA

NCBI chr 5:136,276,989...136,596,429
Ensembl chr 5:136,276,989...136,596,344

G

C-X-C motif chemokine ligand 10

increases secretion
multiple interactions

Gold results in increased secretion of CXCL10 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL10 protein

NCBI chr 5:92,494,497...92,496,748
Ensembl chr 5:92,494,497...92,496,748

G

C-X-C motif chemokine ligand 2

multiple interactions
increases secretion

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL2 mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL2 protein
Gold results in increased secretion of CXCL2 protein

PMID:19695318 PMID:22155353

NCBI chr 5:91,051,758...91,053,797
Ensembl chr 5:91,051,730...91,053,797

G

C-X-C motif chemokine ligand 3

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL1 mRNA

NCBI chr 5:90,933,960...90,935,952
Ensembl chr 5:90,933,962...90,937,459

G

cytochrome c, somatic

multiple interactions

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of CYCS protein

NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
decreases expression
multiple interactions

Gold analog results in increased activity of CYP1A1 protein
Gold analog results in decreased expression of CYP1A1 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of CYP1A1 mRNA

PMID:20193702 PMID:28433809 PMID:36057382

NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107

G

cytochrome P450, family 24, subfamily a, polypeptide 1

increases expression

Gold results in increased expression of CYP24A1 mRNA

NCBI chr 2:170,324,877...170,339,065
Ensembl chr 2:170,324,628...170,339,065

G

cytochrome P450, family 2, subfamily d, polypeptide 22

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA
Gold analog results in decreased expression of CYP2D6 mRNA

PMID:28433809 PMID:36057382

NCBI chr15:82,254,728...82,264,461
Ensembl chr15:82,254,728...82,264,461

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

Gold analog results in decreased expression of CYP2E1 mRNA

NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900

G

cytochrome P450, family 3, subfamily a, polypeptide 11

increases expression

Gold analog results in increased expression of CYP3A11 mRNA

NCBI chr 5:145,791,417...145,816,664
Ensembl chr 5:145,791,236...145,816,774

G

cytochrome P450, family 7, subfamily a, polypeptide 1

increases expression

Gold analog results in increased expression of CYP7A1 mRNA

NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633

G

cytohesin 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CYTH1 mRNA

NCBI chr11:118,054,996...118,139,452
Ensembl chr11:118,022,845...118,139,386

G

disabled 2, mitogen-responsive phosphoprotein

increases expression

Gold results in increased expression of DAB2 mRNA

NCBI chr15:6,329,269...6,470,196
Ensembl chr15:6,329,269...6,470,193

G

decapping mRNA 2

decreases expression

Gold results in decreased expression of DCP2 mRNA

NCBI chr18:44,513,567...44,558,036
Ensembl chr18:44,513,569...44,558,036

G

dopa decarboxylase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DDC mRNA

NCBI chr11:11,764,101...11,848,144
Ensembl chr11:11,764,101...11,848,144

G

DNA-damage inducible transcript 3

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of DDIT3 mRNA

NCBI chr10:127,126,662...127,132,160
Ensembl chr10:127,126,643...127,132,157
Ensembl chr10:127,126,643...127,132,157

G

DNA-damage-inducible transcript 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of DDIT4 mRNA

NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656

G

defensin beta 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DEFB1 mRNA

NCBI chr 8:22,266,571...22,285,201
Ensembl chr 8:22,266,615...22,285,201

G

24-dehydrocholesterol reductase

multiple interactions
decreases expression

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DHCR24 mRNA
Gold analog results in decreased expression of DHCR24 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of DHCR24 mRNA

PMID:19695318 PMID:28433809 PMID:36057382

NCBI chr 4:106,418,279...106,446,310
Ensembl chr 4:106,418,235...106,446,310

G

dihydrolipoamide dehydrogenase

decreases expression

Gold analog results in decreased expression of DLD mRNA

NCBI chr12:31,381,561...31,401,470
Ensembl chr12:31,381,276...31,401,452

G

dynein, axonemal, heavy chain 14

decreases expression

Gold results in decreased expression of DNAH14 mRNA

NCBI chr 1:181,404,158...181,642,306
Ensembl chr 1:181,404,124...181,643,339

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of DNAJA3 mRNA

NCBI chr16:4,501,934...4,525,559
Ensembl chr16:4,457,853...4,525,559

G

DnaJ heat shock protein family (Hsp40) member B14

decreases expression

Gold results in decreased expression of DNAJB14 mRNA

NCBI chr 3:137,572,801...137,619,350
Ensembl chr 3:137,573,436...137,622,318