gold atom - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	gold atom	go back to main search page
Accession:	CHEBI:29287	browse the term
Definition:	A copper group element atom that has formula Au.
Synonyms:	related_synonym:	79Au; Au; Formula=Au; Gold; InChI=1S/Au; InChIKey=PCHJSUWPFVWCPO-UHFFFAOYSA-N; SMILES=[Au]; aurum; or; oro
	xref:	CAS:7440-57-5
	xref_mesh:	MESH:D006046
	xref:	WebElements:Au

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Rat (614) Mouse (622) Human (636) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (636)

gold atom

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminoadipate-semialdehyde synthase

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of AASS mRNA
Gold analog results in decreased expression of AASS mRNA

PMID:28433809 PMID:36057382

NCBI chr 7:122,073,549...122,144,249
Ensembl chr 7:122,064,583...122,144,308

G

ATP binding cassette subfamily B member 1

increases expression

Gold analog results in increased expression of ABCB1 mRNA

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily B member 4

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCB4 mRNA
Gold analog results in decreased expression of ABCB4 mRNA

PMID:28433809 PMID:36057382

NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435

G

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCC1 mRNA

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

G

ATP binding cassette subfamily C member 2

increases expression

Gold analog results in increased expression of ABCC2 mRNA

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ABL1 mRNA

NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675

G

acetyl-CoA acyltransferase 1

decreases expression

Gold analog results in decreased expression of ACAA1 mRNA

NCBI chr 3:38,122,715...38,137,127
Ensembl chr 3:38,103,129...38,137,242

G

acetyl-CoA carboxylase alpha

decreases expression

Gold analog results in decreased expression of ACACA mRNA

NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836

G

acyl-CoA dehydrogenase family member 11

decreases expression

Gold analog results in decreased expression of ACAD11 mRNA

NCBI chr 3:132,558,141...132,659,809
Ensembl chr 3:132,558,138...132,660,082

G

acyl-CoA dehydrogenase medium chain

decreases expression

Gold analog results in decreased expression of ACADM mRNA

NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,431...75,787,575

G

acyl-CoA dehydrogenase short chain

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADS mRNA

NCBI chr12:120,725,826...120,740,008
Ensembl chr12:120,725,774...120,740,008

G

acyl-CoA dehydrogenase very long chain

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADVL mRNA

NCBI chr17:7,217,125...7,225,266
Ensembl chr17:7,217,125...7,225,266

G

aconitase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of ACO1 mRNA

NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769

G

aconitase 2

decreases expression
multiple interactions

Gold analog results in decreased expression of ACO2 protein
[Polyethyleneimine binds to Gold] which results in increased expression of ACO2 mRNA

PMID:24780912 PMID:28433809

NCBI chr22:41,469,117...41,528,974
Ensembl chr22:41,447,830...41,529,273

G

acyl-CoA oxidase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ACOX1 mRNA

NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177

G

acyl-CoA oxidase 2

decreases expression

Gold analog results in decreased expression of ACOX2 mRNA

NCBI chr 3:58,505,136...58,537,190
Ensembl chr 3:58,505,136...58,537,283

G

acid phosphatase 1

decreases expression

Gold results in decreased expression of ACP1 mRNA

NCBI chr 2:264,947...278,283
Ensembl chr 2:264,140...278,283

G

activin A receptor type 1C

decreases expression

Gold results in decreased expression of ACVR1C mRNA

NCBI chr 2:157,526,767...157,628,864
Ensembl chr 2:157,526,767...157,628,864

G

ADAM metallopeptidase domain 28

increases expression

Gold results in increased expression of ADAM28 mRNA

NCBI chr 8:24,294,069...24,359,014
Ensembl chr 8:24,294,069...24,359,014

G

alcohol dehydrogenase 5 (class III), chi polypeptide

decreases expression

Gold results in decreased expression of ADH5 mRNA

NCBI chr 4:99,070,978...99,088,788
Ensembl chr 4:99,070,978...99,088,801

G

adiponectin receptor 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ADIPOR2 mRNA

NCBI chr12:1,691,070...1,788,674
Ensembl chr12:1,688,574...1,788,674

G

adrenoceptor alpha 1B

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRA1B mRNA

NCBI chr 5:159,865,086...159,989,205
Ensembl chr 5:159,865,080...159,973,012

G

adrenoceptor beta 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRB2 mRNA

NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623

G

alpha 2-HS glycoprotein

decreases expression

Gold analog results in decreased expression of AHSG mRNA

NCBI chr 3:186,613,060...186,621,318
Ensembl chr 3:186,613,060...186,621,318

G

apoptosis inducing factor mitochondria associated 1

increases expression

Gold results in increased expression of AIFM1 protein

NCBI chr X:130,129,362...130,165,841
Ensembl chr X:130,124,666...130,165,879

G

aminoacyl tRNA synthetase complex interacting multifunctional protein 1

decreases expression

Gold results in decreased expression of AIMP1 mRNA

NCBI chr 4:106,315,544...106,349,456
Ensembl chr 4:106,315,544...106,349,456

G

adenylate kinase 3

decreases expression

Gold results in decreased expression of AK3 mRNA

NCBI chr 9:4,709,556...4,742,043
Ensembl chr 9:4,709,556...4,742,043

G

A-kinase anchoring protein 13

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of AKAP13 mRNA

NCBI chr15:85,380,603...85,749,358
Ensembl chr15:85,380,571...85,749,358

G

aldo-keto reductase family 1 member B10

increases expression

Gold results in increased expression of AKR1B10 mRNA

NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412

G

aldo-keto reductase family 1 member C2

increases expression

Gold results in increased expression of AKR1C2 mRNA

NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031

G

aldo-keto reductase family 1 member C3

increases expression

Gold results in increased expression of AKR1C3 mRNA

NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686

G

AKT serine/threonine kinase 1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of AKT1 protein

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

albumin

multiple interactions
increases expression

ALB protein results in increased uptake of [Polyethylene Glycols binds to Gold]; ALB protein results in increased uptake of [Polyethyleneimine binds to Gold]; ALB protein results in increased uptake of [Thioctic Acid binds to Gold]
Gold analog results in increased expression of ALB mRNA

PMID:28433809 PMID:36057382

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

annexin A5

increases expression

Gold analog results in increased expression of ANXA5 protein

NCBI chr 4:121,667,946...121,696,980
Ensembl chr 4:121,667,946...121,696,995

G

apoptotic peptidase activating factor 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of APAF1 mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein
Gold analog results in decreased expression of APAF1 mRNA

PMID:27470402 PMID:28433809 PMID:36057382

NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,149...98,735,433

G

apurinic/apyrimidinic endodeoxyribonuclease 1

decreases expression

Gold analog results in decreased expression of APEX1 mRNA

NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772

G

apolipoprotein A4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of APOA4 mRNA

NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304

G

adenine phosphoribosyltransferase

decreases expression

Gold analog results in decreased expression of APRT protein

NCBI chr16:88,809,339...88,811,928
Ensembl chr16:88,809,339...88,811,937

G

aquaporin 4

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of AQP4 mRNA

NCBI chr18:26,852,038...26,865,803
Ensembl chr18:26,852,043...26,865,771

G

ARF like GTPase 1

decreases expression

Gold results in decreased expression of ARL1 mRNA

NCBI chr12:101,393,116...101,407,820
Ensembl chr12:101,393,116...101,407,772

G

ARF like GTPase 5B

decreases expression

Gold results in decreased expression of ARL5B mRNA

NCBI chr10:18,659,431...18,681,639
Ensembl chr10:18,659,431...18,681,639

G

arylsulfatase G

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ARSG mRNA

NCBI chr17:68,259,170...68,452,019
Ensembl chr17:68,259,182...68,422,731

G

N-acylsphingosine amidohydrolase 1

decreases expression

Gold analog results in decreased expression of ASAH1 mRNA

NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998

G

activating transcription factor 1

decreases expression

Gold results in decreased expression of ATF1 mRNA

NCBI chr12:50,763,459...50,821,162
Ensembl chr12:50,763,710...50,821,162

G

activating transcription factor 4

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ATF4 mRNA

NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,686

G

activating transcription factor 6

increases cleavage

Gold analog results in increased cleavage of ATF6 protein

NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

decreases expression

Gold analog results in decreased expression of ATIC protein

NCBI chr 2:215,312,059...215,368,592
Ensembl chr 2:215,311,956...215,349,773

G

atlastin GTPase 2

decreases expression

Gold results in decreased expression of ATL2 mRNA

NCBI chr 2:38,293,954...38,378,584
Ensembl chr 2:38,293,954...38,377,285

G

ATM serine/threonine kinase

decreases expression

Gold analog results in decreased expression of ATM mRNA

NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,804...108,369,102

G

ATPase plasma membrane Ca2+ transporting 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ATP2B1 mRNA

NCBI chr12:89,588,049...89,709,366
Ensembl chr12:89,588,049...89,709,366

G

ATP synthase F1 subunit beta

multiple interactions

Gold analog results in increased expression of and results in decreased phosphorylation of ATP5F1B protein

NCBI chr12:56,638,175...56,645,984
Ensembl chr12:56,638,175...56,645,984

G

ATPase H+ transporting V1 subunit G2

decreases expression

Gold analog results in decreased expression of ATP6V1G2 mRNA

NCBI chr 6:31,544,444...31,546,742
Ensembl chr 6:31,544,444...31,548,427

G

ATR serine/threonine kinase

decreases expression

Gold analog results in decreased expression of ATR mRNA

NCBI chr 3:142,449,235...142,578,733
Ensembl chr 3:142,449,007...142,578,733

G

beta-secretase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BACE1 mRNA

NCBI chr11:117,285,698...117,316,256
Ensembl chr11:117,285,232...117,316,259

G

BCL2 associated agonist of cell death

multiple interactions

[Quercetin analog co-treated with Gold analog] results in increased expression of BAD protein

NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704

G

BAR/IMD domain containing adaptor protein 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of BAIAP2 mRNA

NCBI chr17:81,035,151...81,117,434
Ensembl chr17:81,035,122...81,117,434

G

BCL2 antagonist/killer 1

increases expression

Gold results in increased expression of BAK1 mRNA

NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein; [Gold analog co-treated with Platinum] results in increased expression of BAX mRNA; [Polyethyleneimine binds to Gold] which results in decreased expression of BAX mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of BAX protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of BAX protein
Gold results in increased expression of BAX mRNA

PMID:21621595 PMID:22178767 PMID:25846798 PMID:27470402 PMID:27836789 More...

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCAS2 pre-mRNA processing factor

decreases expression

Gold results in decreased expression of BCAS2 mRNA

NCBI chr 1:114,567,557...114,581,615
Ensembl chr 1:114,567,557...114,581,629

G

BCL2 apoptosis regulator

multiple interactions

[Gold analog co-treated with Platinum] results in decreased expression of BCL2 mRNA; [Quercetin analog co-treated with Gold analog] results in decreased expression of BCL2 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in decreased expression of BCL2 protein

PMID:25846798 PMID:27470402 PMID:27836789

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of BCL2L1 mRNA

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

BCL2 like 11

decreases expression

Gold analog results in decreased expression of BCL2L11 mRNA

NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444

G

baculoviral IAP repeat containing 2

decreases expression

Gold results in decreased expression of BIRC2 mRNA

NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670

G

baculoviral IAP repeat containing 3

decreases expression

Gold analog results in decreased expression of BIRC3 mRNA; Gold results in decreased expression of BIRC3 mRNA

PMID:25523186 PMID:36057382

NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403

G

basic helix-loop-helix ARNT like 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BMAL1 mRNA

NCBI chr11:13,276,652...13,387,266
Ensembl chr11:13,276,652...13,387,266

G

BMI1 proto-oncogene, polycomb ring finger

decreases expression

Gold results in decreased expression of BMI1 mRNA

NCBI chr10:22,321,099...22,331,706
Ensembl chr10:22,321,099...22,331,484

G

BRCA1 DNA repair associated

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA1 mRNA
Gold analog results in decreased expression of BRCA1 mRNA

PMID:28433809 PMID:36057382

NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245

G

BRCA2 DNA repair associated

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA2 mRNA
Gold analog results in decreased expression of BRCA2 mRNA

PMID:28433809 PMID:36057382

NCBI chr13:32,315,077...32,400,268
Ensembl chr13:32,315,086...32,400,268

G

chromosome 11 open reading frame 54

decreases expression

Gold results in decreased expression of C11ORF54 mRNA

NCBI chr11:93,741,672...93,764,749
Ensembl chr11:93,741,591...93,764,749

G

C1D nuclear receptor corepressor

decreases expression

Gold results in decreased expression of C1D mRNA

NCBI chr 2:68,041,130...68,063,004
Ensembl chr 2:68,041,130...68,110,948

G

complement C3

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of C3 mRNA

NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562

G

complement C9

decreases expression

Gold analog results in decreased expression of C9 mRNA

NCBI chr 5:39,284,140...39,364,495
Ensembl chr 5:39,284,140...39,371,324

G

carbonic anhydrase 13

decreases expression

Gold results in decreased expression of CA13 mRNA

NCBI chr 8:85,245,458...85,284,073
Ensembl chr 8:85,220,587...85,284,073

G

capping actin protein of muscle Z-line subunit alpha 2

decreases expression

Gold results in decreased expression of CAPZA2 mRNA

NCBI chr 7:116,862,587...116,922,049
Ensembl chr 7:116,811,070...116,922,049

G

caspase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of CASP1 mRNA

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 3

multiple interactions
increases activity
increases cleavage
increases expression

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP3 mRNA; [Polyethyleneimine binds to Gold] which results in increased expression of CASP3 mRNA; [Quercetin analog co-treated with Gold analog] results in increased cleavage of CASP3 protein; [Quercetin analog co-treated with Gold analog] results in increased expression of and results in increased activity of CASP3 protein; Dexamethasone promotes the reaction [Gold results in increased activity of CASP3 protein]; Etoposide promotes the reaction [Gold results in increased activity of CASP3 protein]
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP3 protein
Gold analog results in increased cleavage of CASP3 protein
Gold results in increased expression of CASP3 mRNA

PMID:19760634 PMID:21621595 PMID:22178767 PMID:25846798 PMID:26551149 More...

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 4

increases cleavage

Gold analog results in increased cleavage of CASP4 protein

NCBI chr11:104,942,866...104,968,574
Ensembl chr11:104,942,866...104,969,366

G

caspase 7

increases cleavage

Gold analog results in increased cleavage of CASP7 protein

NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907

G

caspase 8

increases expression
decreases expression

Gold results in increased expression of CASP8 mRNA
Gold analog results in decreased expression of CASP8 mRNA

PMID:22178767 PMID:36057382

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

multiple interactions
increases cleavage

[Gold analog co-treated with Platinum] results in increased activity of CASP9 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP9 mRNA
Gold analog results in increased cleavage of CASP9 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP9 protein

PMID:25846798 PMID:26551149 PMID:27836789

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

catalase

multiple interactions

[Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

chromobox 3

decreases expression

Gold results in decreased expression of CBX3 mRNA

NCBI chr 7:26,201,443...26,213,607
Ensembl chr 7:26,201,162...26,213,607

G

C-C motif chemokine ligand 2

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL2 protein
Gold results in increased secretion of CCL2 protein

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

C-C motif chemokine ligand 5

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL5 protein
Gold results in increased secretion of CCL5 protein

NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793

G

C-C motif chemokine ligand 7

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL7 protein
Gold results in increased secretion of CCL7 protein

NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242

G

cyclin D1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased expression of CCND1 protein

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

chaperonin containing TCP1 subunit 5

decreases expression

Gold analog results in decreased expression of CCT5 protein

NCBI chr 5:10,249,921...10,266,412
Ensembl chr 5:10,249,929...10,266,389

G

CD19 molecule

increases expression

Gold analog results in increased expression of CD19 mRNA

NCBI chr16:28,931,971...28,939,342
Ensembl chr16:28,931,965...28,939,342

G

CD36 molecule (CD36 blood group)

decreases expression

Gold analog results in decreased expression of CD36 mRNA

NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277

G

CD40 molecule

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CD40 mRNA

NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863

G

CD86 molecule

decreases expression

Gold analog results in decreased expression of CD86 mRNA

NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139

G

cytidine deaminase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CDA mRNA

NCBI chr 1:20,589,097...20,618,903
Ensembl chr 1:20,589,086...20,618,903

G

cyclin dependent kinase 1

decreases expression
increases expression

Gold results in decreased expression of CDK1 mRNA
Gold results in increased expression of CDK1 mRNA

PMID:25523186 PMID:29705079

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

cyclin dependent kinase 7

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CDK7 mRNA

NCBI chr 5:69,234,795...69,277,430
Ensembl chr 5:69,234,795...69,277,430

G

cyclin dependent kinase inhibitor 1B

multiple interactions

[Gold binds to Dimethyldithiocarbamate] which results in increased expression of CDKN1B protein

NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369

G

CDKN2A interacting protein

decreases expression

Gold results in decreased expression of CDKN2AIP mRNA

NCBI chr 4:183,444,636...183,449,064
Ensembl chr 4:183,444,635...183,449,064

G

cell growth regulator with ring finger domain 1

decreases expression

Gold results in decreased expression of CGRRF1 mRNA

NCBI chr14:54,509,906...54,539,292
Ensembl chr14:54,509,812...54,539,292

G

checkpoint kinase 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA
Gold analog results in decreased expression of CHEK1 mRNA

PMID:28433809 PMID:36057382

NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255

G

checkpoint kinase 2

decreases expression

Gold analog results in decreased expression of CHEK2 mRNA

NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422

G

cysteine and histidine rich domain containing 1

decreases expression

Gold results in decreased expression of CHORDC1 mRNA

NCBI chr11:90,200,429...90,223,049
Ensembl chr11:90,200,429...90,223,077

G

CDGSH iron sulfur domain 1

decreases expression

Gold results in decreased expression of CISD1 mRNA

NCBI chr10:58,269,162...58,289,586
Ensembl chr10:58,269,162...58,289,586

G

claudin 12

decreases expression

Gold results in decreased expression of CLDN12 mRNA

NCBI chr 7:90,403,461...90,415,954
Ensembl chr 7:90,383,721...90,513,402

G

CCHC-type zinc finger nucleic acid binding protein

decreases expression

Gold results in decreased expression of CNBP mRNA

NCBI chr 3:129,167,827...129,183,896
Ensembl chr 3:129,167,827...129,183,922

G

CCR4-NOT transcription complex subunit 7

decreases expression

Gold results in decreased expression of CNOT7 mRNA

NCBI chr 8:17,224,966...17,246,857
Ensembl chr 8:17,224,966...17,246,878

G

collagen type I alpha 1 chain

increases expression

Gold analog results in increased expression of COL1A1 protein

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

G

collagen type I alpha 2 chain

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL1A2 mRNA

NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227

G

collagen type III alpha 1 chain

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL3A1 mRNA

NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746

G

COMM domain containing 8

decreases expression

Gold results in decreased expression of COMMD8 mRNA

NCBI chr 4:47,450,787...47,463,702
Ensembl chr 4:47,450,787...47,463,702

G

cytochrome c oxidase copper chaperone COX11

decreases expression

Gold results in decreased expression of COX11 mRNA

NCBI chr17:54,951,902...54,968,785
Ensembl chr17:54,951,902...54,968,703

G

cytochrome c oxidase copper chaperone COX17

decreases expression

Gold results in decreased expression of COX17 mRNA

NCBI chr 3:119,663,975...119,677,406
Ensembl chr 3:119,654,513...119,677,454

G

carnitine palmitoyltransferase 1A

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT1A mRNA

NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410

G

carnitine palmitoyltransferase 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT2 mRNA

NCBI chr 1:53,196,824...53,214,197
Ensembl chr 1:53,196,792...53,214,197

G

carnitine O-octanoyltransferase

decreases expression

Gold analog results in decreased expression of CROT mRNA

NCBI chr 7:87,345,664...87,399,794
Ensembl chr 7:87,345,664...87,399,794

G

colony stimulating factor 2

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF2 protein
Gold results in increased secretion of CSF2 protein

NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170

G

colony stimulating factor 3

increases secretion
multiple interactions

Gold results in increased secretion of CSF3 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF3 protein

NCBI chr17:40,015,440...40,017,813
Ensembl chr17:40,015,361...40,017,813

G

CCCTC-binding factor

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CTCF mRNA

NCBI chr16:67,562,526...67,639,185
Ensembl chr16:67,562,467...67,639,177

G

cut like homeobox 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CUX1 mRNA

NCBI chr 7:101,816,007...102,283,958
Ensembl chr 7:101,815,904...102,283,958

G

C-X-C motif chemokine ligand 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL1 mRNA

NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308

G

C-X-C motif chemokine ligand 10

increases secretion
multiple interactions

Gold results in increased secretion of CXCL10 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL10 protein

NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497

G

C-X-C motif chemokine ligand 2

multiple interactions
increases secretion

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL2 mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL2 protein
Gold results in increased secretion of CXCL2 protein

PMID:19695318 PMID:22155353

NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196

G

cytochrome c, somatic

multiple interactions

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of CYCS protein

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

cytochrome P450 family 1 subfamily A member 1

increases activity
decreases expression
multiple interactions

Gold analog results in increased activity of CYP1A1 protein
Gold analog results in decreased expression of CYP1A1 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of CYP1A1 mRNA

PMID:20193702 PMID:28433809 PMID:36057382

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 24 subfamily A member 1

increases expression

Gold results in increased expression of CYP24A1 mRNA

NCBI chr20:54,143,538...54,173,986
Ensembl chr20:54,153,446...54,173,986

G

cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA
Gold analog results in decreased expression of CYP2D6 mRNA

PMID:28433809 PMID:36057382

NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865

G

cytochrome P450 family 2 subfamily E member 1

decreases expression

Gold analog results in decreased expression of CYP2E1 mRNA

NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220

G

cytochrome P450 family 7 subfamily A member 1

increases expression

Gold analog results in increased expression of CYP7A1 mRNA

NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163

G

cytohesin 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CYTH1 mRNA

NCBI chr17:78,674,048...78,782,273
Ensembl chr17:78,674,048...78,782,297

G

DAB adaptor protein 2

increases expression

Gold results in increased expression of DAB2 mRNA

NCBI chr 5:39,371,677...39,424,980
Ensembl chr 5:39,371,675...39,462,300

G

decapping mRNA 2

decreases expression

Gold results in decreased expression of DCP2 mRNA

NCBI chr 5:112,976,798...113,022,195
Ensembl chr 5:112,976,702...113,022,195

G

dopa decarboxylase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DDC mRNA

NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405

G

DNA damage inducible transcript 3

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of DDIT3 mRNA

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

DNA damage inducible transcript 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of DDIT4 mRNA

NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036

G

defensin beta 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DEFB1 mRNA

NCBI chr 8:6,870,592...6,877,936
Ensembl chr 8:6,870,592...6,877,936

G

24-dehydrocholesterol reductase

multiple interactions
decreases expression

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DHCR24 mRNA
Gold analog results in decreased expression of DHCR24 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of DHCR24 mRNA

PMID:19695318 PMID:28433809 PMID:36057382

NCBI chr 1:54,849,627...54,887,195
Ensembl chr 1:54,849,627...54,887,195

G

dihydrolipoamide dehydrogenase

decreases expression

Gold analog results in decreased expression of DLD mRNA

NCBI chr 7:107,891,107...107,921,198
Ensembl chr 7:107,891,162...107,931,730

G

dynein axonemal heavy chain 14

decreases expression

Gold results in decreased expression of DNAH14 mRNA

NCBI chr 1:224,929,654...225,399,286
Ensembl chr 1:224,896,262...225,399,292

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of DNAJA3 mRNA

NCBI chr16:4,425,868...4,456,775
Ensembl chr16:4,425,805...4,456,775

G

DnaJ heat shock protein family (Hsp40) member B14

decreases expression

Gold results in decreased expression of DNAJB14 mRNA

NCBI chr 4:99,896,248...99,946,618
Ensembl chr 4:99,896,248...99,946,618

G

DnaJ heat shock protein family (Hsp40) member B6

decreases expression

Gold results in decreased expression of DNAJB6 mRNA

NCBI chr 7:157,337,004...157,417,439
Ensembl chr 7:157,335,381...157,417,439

G

DnaJ heat shock protein family (Hsp40) member B9

decreases expression

Gold results in decreased expression of DNAJB9 mRNA

NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850

G

DnaJ heat shock protein family (Hsp40) member C10

decreases expression

Gold results in decreased expression of DNAJC10 mRNA

NCBI chr 2:182,716,257...182,794,464
Ensembl chr 2:182,716,255...182,794,464

G

DnaJ heat shock protein family (Hsp40) member C19

decreases expression

Gold results in decreased expression of DNAJC19 mRNA

NCBI chr 3:180,983,709...180,989,838
Ensembl chr 3:180,983,697...180,989,774

G

DnaJ heat shock protein family (Hsp40) member C21

decreases expression

Gold results in decreased expression of DNAJC21 mRNA

NCBI chr 5:34,929,559...34,958,964
Ensembl chr 5:34,929,559...34,958,964

G

DnaJ heat shock protein family (Hsp40) member C5

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DNAJC5 mRNA

NCBI chr20:63,895,126...63,936,011
Ensembl chr20:63,895,126...63,936,031

G

dihydropyrimidinase like 4

increases expression

Gold analog results in increased expression of DPYSL4 mRNA

NCBI chr10:132,186,948...132,205,759
Ensembl chr10:132,186,948...132,205,759

G

dopamine receptor D3

multiple interactions

Gold inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]

NCBI chr 3:114,127,580...114,199,407
Ensembl chr 3:114,127,580...114,199,407

G

dopamine receptor D4

multiple interactions

Gold inhibits the reaction [3-N-methylspiperone binds to DRD4 protein]

NCBI chr11:637,269...640,706
Ensembl chr11:637,269...640,706

G

desmocollin 2

increases expression

Gold results in increased expression of DSC2 mRNA

NCBI chr18:31,058,840...31,102,421
Ensembl chr18:31,058,545...31,102,600

G

desmoglein 2

increases expression

Gold results in increased expression of DSG2 mRNA

NCBI chr18:31,498,177...31,549,008
Ensembl chr18:31,497,624...31,551,351

G

dual oxidase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DUOX1 mRNA

NCBI chr15:45,129,994...45,165,574
Ensembl chr15:45,129,933...45,165,576

G

dual oxidase 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of DUOX2 mRNA

NCBI chr15:45,092,650...45,114,172
Ensembl chr15:45,092,650...45,114,172

G

dual specificity phosphatase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of DUSP1 mRNA

NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195

G

dual specificity phosphatase 11

decreases expression

Gold results in decreased expression of DUSP11 mRNA

NCBI chr 2:73,762,213...73,780,149
Ensembl chr 2:73,761,782...73,780,173

G

deoxyuridine triphosphatase

decreases expression

Gold results in decreased expression of DUT mRNA

NCBI chr15:48,331,095...48,343,373
Ensembl chr15:48,331,011...48,343,373

G

DAZ interacting zinc finger protein 3

decreases expression

Gold results in decreased expression of DZIP3 mRNA

NCBI chr 3:108,589,510...108,694,840
Ensembl chr 3:108,589,705...108,694,840

G

ER degradation enhancing alpha-mannosidase like protein 3

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of EDEM3 mRNA
Gold analog results in decreased expression of EDEM3 mRNA

PMID:28433809 PMID:36057382

NCBI chr 1:184,690,237...184,754,858
Ensembl chr 1:184,690,237...184,754,907

G

early endosome antigen 1

decreases expression

Gold results in decreased expression of EEA1 mRNA

NCBI chr12:92,770,637...92,929,295
Ensembl chr12:92,770,637...92,929,331

G

eukaryotic translation elongation factor 1 delta

decreases expression

Gold analog results in decreased expression of EEF1D protein

NCBI chr 8:143,579,728...143,597,415
Ensembl chr 8:143,579,697...143,599,541

G

eukaryotic translation elongation factor 2

decreases expression

Gold analog results in decreased expression of EEF2 protein

NCBI chr19:3,976,056...3,985,463
Ensembl chr19:3,976,056...3,985,463

G

epidermal growth factor

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766

G

epidermal growth factor receptor

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

decreases expression

Gold analog results in decreased expression of EHHADH mRNA

NCBI chr 3:185,190,624...185,254,049
Ensembl chr 3:185,190,624...185,281,990

G

EP300 interacting inhibitor of differentiation 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of EID1 mRNA

NCBI chr15:48,878,134...48,880,173
Ensembl chr15:48,878,134...48,880,173

G

eukaryotic translation initiation factor 1A X-linked

decreases expression

Gold results in decreased expression of EIF1AX mRNA

NCBI chr X:20,124,525...20,141,838
Ensembl chr X:20,124,525...20,141,838

G

eukaryotic translation initiation factor 1A Y-linked

decreases expression

Gold results in decreased expression of EIF1AY mRNA

NCBI chr Y:20,575,776...20,593,154
Ensembl chr Y:20,575,776...20,593,154

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation

Gold analog results in increased phosphorylation of EIF2AK3 protein

NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518

G

eukaryotic translation initiation factor 4A2

decreases expression

Gold results in decreased expression of EIF4A2 mRNA

NCBI chr 3:186,783,577...186,789,897
Ensembl chr 3:186,783,205...186,789,897

G

eukaryotic translation initiation factor 4E

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased expression of EIF4E protein

NCBI chr 4:98,879,276...98,929,133
Ensembl chr 4:98,879,276...98,929,133

G

eukaryotic translation initiation factor 4E binding protein 3

multiple interactions

[Quercetin analog co-treated with Gold analog] results in increased expression of EIF4EBP3 protein

NCBI chr 5:140,547,662...140,549,576
Ensembl chr 5:140,547,662...140,549,576

G

eukaryotic translation initiation factor 5B

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of EIF5B mRNA
Gold analog results in decreased expression of EIF5B mRNA

PMID:28433809 PMID:36057382

NCBI chr 2:99,337,389...99,401,326
Ensembl chr 2:99,337,389...99,401,326

G

enolase 1

multiple interactions

Gold analog results in decreased expression of and results in increased phosphorylation of ENO1 protein

NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190

G

E1A binding protein p300

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]; [Polyethyleneimine binds to Gold] which results in decreased expression of EP300 mRNA; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]

PMID:27634460 PMID:28433809

NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,510...41,180,077

G

epithelial mitogen

increases expression

Gold results in increased expression of EPGN mRNA

NCBI chr 4:74,308,470...74,316,789
Ensembl chr 4:74,308,470...74,316,789

G

EPH receptor A1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of EPHA1 mRNA

NCBI chr 7:143,391,129...143,408,856
Ensembl chr 7:143,390,289...143,408,856

G

epoxide hydrolase 1

increases expression

Gold analog results in increased expression of EPHX1 mRNA

NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563

G

ERCC excision repair 2, TFIIH core complex helicase subunit

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ERCC2 mRNA

NCBI chr19:45,349,837...45,370,573
Ensembl chr19:45,349,837...45,370,918

G

ERCC excision repair 6, chromatin remodeling factor

decreases expression

Gold analog results in decreased expression of ERCC6 mRNA

NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,168...49,539,538

G

endoplasmic reticulum to nucleus signaling 1

increases phosphorylation

Gold analog results in increased phosphorylation of ERN1 protein

NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819

G

endoplasmic reticulum to nucleus signaling 2

increases expression

Gold analog results in increased expression of ERN2 mRNA

NCBI chr16:23,690,310...23,713,222
Ensembl chr16:23,690,310...23,713,226

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

Gold results in increased expression of ERO1A mRNA

NCBI chr14:52,639,915...52,695,558
Ensembl chr14:52,639,915...52,695,900

G

establishment of sister chromatid cohesion N-acetyltransferase 2

decreases expression

Gold results in decreased expression of ESCO2 mRNA

NCBI chr 8:27,771,974...27,819,660
Ensembl chr 8:27,771,949...27,812,640

G

estrogen receptor 1

decreases expression

Gold analog results in decreased expression of ESR1 mRNA

NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619

G

ecotropic viral integration site 5

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of EVI5 mRNA

NCBI chr 1:92,508,696...92,792,410
Ensembl chr 1:92,508,696...92,792,404

G

even-skipped homeobox 1

increases expression

Gold results in increased expression of EVX1 mRNA

NCBI chr 7:27,242,802...27,247,830
Ensembl chr 7:27,242,700...27,250,493

G

FA complementation group L

decreases expression

Gold results in decreased expression of FANCL mRNA

NCBI chr 2:58,159,243...58,241,380
Ensembl chr 2:58,159,243...58,241,410

G

Fas cell surface death receptor

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of FAS mRNA
Gold analog results in decreased expression of FAS mRNA

PMID:28433809 PMID:36057382

NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605

G

fatty acid synthase

decreases expression

Gold analog results in decreased expression of FASN mRNA

NCBI chr17:82,078,338...82,098,236
Ensembl chr17:82,078,338...82,098,294

G

fibroblast growth factor 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of FGF1 mRNA

NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070

G

fumarate hydratase

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of FH mRNA

NCBI chr 1:241,497,603...241,519,755
Ensembl chr 1:241,497,511...241,519,799

G

FKBP prolyl isomerase 9

increases phosphorylation
decreases expression

Gold analog results in increased phosphorylation of FKBP9 protein
Gold analog results in decreased expression of FKBP9 protein

NCBI chr 7:32,957,440...33,006,928
Ensembl chr 7:32,957,404...33,006,930

G

flavin containing dimethylaniline monoxygenase 5

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of FMO5 mRNA

NCBI chr 1:147,184,305...147,227,284
Ensembl chr 1:147,175,351...147,243,050

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

[Gold co-treated with Silicon Dioxide] results in increased expression of FOS mRNA
Gold results in increased expression of FOS mRNA

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,283,190

G

ferritin heavy chain 1

increases expression

Gold results in increased expression of FTH1 mRNA

NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634

G

FYN binding protein 1

increases expression

Gold results in increased expression of FYB1 mRNA

NCBI chr 5:39,105,252...39,274,528
Ensembl chr 5:39,105,252...39,274,528

G

frizzled class receptor 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of FZD4 mRNA

NCBI chr11:86,945,679...86,955,395
Ensembl chr11:86,945,679...86,955,395

G

G2/M-phase specific E3 ubiquitin protein ligase

decreases expression

Gold results in decreased expression of G2E3 mRNA

NCBI chr14:30,559,158...30,620,064
Ensembl chr14:30,559,158...30,620,064

G

polypeptide N-acetylgalactosaminyltransferase 1

decreases expression

Gold results in decreased expression of GALNT1 mRNA

NCBI chr18:35,580,922...35,711,834
Ensembl chr18:35,581,117...35,711,834

G

polypeptide N-acetylgalactosaminyltransferase 5

decreases expression

Gold analog results in decreased expression of GALNT5 mRNA

NCBI chr 2:157,257,705...157,318,491
Ensembl chr 2:157,257,705...157,318,491

G

glucosidase alpha, neutral C

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of GANC mRNA

NCBI chr15:42,273,201...42,353,666
Ensembl chr15:42,273,201...42,353,666

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

Gold analog results in decreased expression of GAPDH protein

NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374

G

grancalcin

decreases expression

Gold results in decreased expression of GCA mRNA

NCBI chr 2:162,318,763...162,375,396
Ensembl chr 2:162,318,840...162,371,595

G

glutaryl-CoA dehydrogenase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of GCDH mRNA

NCBI chr19:12,891,129...12,899,999
Ensembl chr19:12,891,128...12,915,126

G

guanine monophosphate synthase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of GMPS mRNA

NCBI chr 3:155,869,430...155,944,020
Ensembl chr 3:155,870,650...155,944,020

G

G protein subunit gamma 10

decreases expression

Gold results in decreased expression of GNG10 mRNA

NCBI chr 9:111,661,605...111,670,226
Ensembl chr 9:111,661,605...111,670,226

G

glutamic-oxaloacetic transaminase 2

decreases expression

Gold analog results in decreased expression of GOT2 protein

NCBI chr16:58,707,131...58,734,316
Ensembl chr16:58,707,131...58,734,342

G

G protein-coupled receptor 182

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of GPR182 mRNA

NCBI chr12:56,994,492...56,998,877
Ensembl chr12:56,994,492...56,998,447

G

glutamic--pyruvic transaminase

multiple interactions
decreases expression

[Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; [Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]
Gold analog results in decreased expression of GPT mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of GPT mRNA

PMID:27836789 PMID:28433809 PMID:36057382

NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174

G

glutathione peroxidase 2

increases expression

Gold analog results in increased expression of GPX2 mRNA; Gold results in increased expression of GPX2 mRNA

PMID:25523186 PMID:36057382

NCBI chr14:64,939,158...64,942,745
Ensembl chr14:64,939,152...64,942,746

G

glutathione peroxidase 3

increases expression

Gold analog results in increased expression of GPX3 mRNA

NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,591...151,028,988

G

gelsolin

decreases expression
increases degradation

Gold analog results in decreased expression of GSN protein
Gold analog results in increased degradation of GSN protein

PMID:24780912 PMID:26551149

NCBI chr 9:121,201,483...121,332,842
Ensembl chr 9:121,207,794...121,332,843

G

glutathione S-transferase mu 4

multiple interactions
increases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of GSTM4 mRNA
Gold analog results in increased expression of GSTM4 mRNA

PMID:28433809 PMID:36057382

NCBI chr 1:109,656,099...109,667,727
Ensembl chr 1:109,656,099...109,665,496

G

GTF2H2 family member C, copy 2

decreases expression

Gold results in decreased expression of GTF2H2C_2 mRNA

G

3-hydroxyanthranilate 3,4-dioxygenase

increases expression

Gold analog results in increased expression of HAAO mRNA

NCBI chr 2:42,767,089...42,792,583
Ensembl chr 2:42,767,089...42,792,593

G

histone acetyltransferase 1

decreases expression

Gold results in decreased expression of HAT1 mRNA

NCBI chr 2:171,922,461...171,983,686
Ensembl chr 2:171,922,448...171,983,686

G

hepatitis A virus cellular receptor 1

multiple interactions

[Polyethylene Glycols binds to Gold] which results in increased expression of HAVCR1 protein; [Polyethyleneimine binds to Gold] which results in increased expression of HAVCR1 protein; [Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein

NCBI chr 5:157,029,413...157,069,407
Ensembl chr 5:157,026,742...157,069,396

G

hydroxycarboxylic acid receptor 2

increases expression

Gold results in increased expression of HCAR2 mRNA

NCBI chr12:122,701,293...122,703,357
Ensembl chr12:122,701,293...122,703,357

G

hexosaminidase subunit beta

multiple interactions

[gold chloride results in increased abundance of Gold] which results in increased export of HEXB protein; [gold tetrachloride, acid results in increased abundance of Gold] which results in increased export of HEXB protein

NCBI chr 5:74,640,023...74,721,288
Ensembl chr 5:74,640,023...74,722,647

G

major histocompatibility complex, class I, B

affects response to substance

HLA-B gene polymorphism affects the susceptibility to Gold

NCBI chr 6:31,353,875...31,357,179
Ensembl chr 6:31,353,872...31,367,067

G

major histocompatibility complex, class II, DR beta 1

increases expression

Gold analog results in increased expression of HLA-DRB1 mRNA

NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848

G

high mobility group box 2

decreases expression

Gold results in decreased expression of HMGB2 mRNA

NCBI chr 4:173,331,376...173,334,358
Ensembl chr 4:173,331,376...173,334,432

G

heme oxygenase 1

increases expression

Gold results in increased expression of HMOX1 mRNA

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

homeobox A3

decreases expression

Gold analog results in decreased expression of HOXA3 mRNA

NCBI chr 7:27,107,010...27,152,583
Ensembl chr 7:27,106,184...27,152,583

G

hypoxanthine phosphoribosyltransferase 1

decreases expression

Gold results in decreased expression of HPRT1 mRNA

NCBI chr X:134,460,165...134,500,668
Ensembl chr X:134,460,165...134,520,513

G

hemopexin

decreases expression

Gold analog results in decreased expression of HPX mRNA

NCBI chr11:6,431,049...6,440,987
Ensembl chr11:6,431,049...6,442,617

G

heat shock factor binding protein 1

decreases expression

Gold results in decreased expression of HSBP1 mRNA

NCBI chr16:83,807,978...83,819,737
Ensembl chr16:83,719,311...83,819,737

G

heat shock transcription factor 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of HSF1 mRNA

NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720

G

heat shock protein 90 alpha family class B member 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSP90AB1 mRNA

NCBI chr 6:44,246,194...44,253,883
Ensembl chr 6:44,246,166...44,253,888

G

heat shock protein family A (Hsp70) member 13

decreases expression

Gold results in decreased expression of HSPA13 mRNA

NCBI chr21:14,371,115...14,383,146
Ensembl chr21:14,371,115...14,383,484

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of HSPA1A mRNA

NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946

G

heat shock protein family A (Hsp70) member 1B

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of HSPA1B mRNA

NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254

G

heat shock protein family A (Hsp70) member 2

decreases expression

Gold analog results in decreased expression of HSPA2 mRNA

NCBI chr14:64,535,905...64,543,237
Ensembl chr14:64,535,905...64,546,173

G

heat shock protein family A (Hsp70) member 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSPA4 mRNA

NCBI chr 5:133,052,013...133,106,449
Ensembl chr 5:133,052,013...133,106,449

G

heat shock protein family A (Hsp70) member 8

increases expression

Gold analog results in increased expression of HSPA8 protein

NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230

G

heat shock protein family A (Hsp70) member 9

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of HSPA9 mRNA

NCBI chr 5:138,553,756...138,575,401
Ensembl chr 5:138,553,756...138,575,675

G

heat shock protein family B (small) member 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSPB1 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of HSPB1 mRNA

PMID:19695318 PMID:28433809

NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,305,813

G

heat shock protein family D (Hsp60) member 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of HSPD1 mRNA

NCBI chr 2:197,486,584...197,500,274
Ensembl chr 2:197,486,584...197,516,737

G

HIV-1 Tat interactive protein 2

increases expression

Gold results in increased expression of HTATIP2 mRNA

NCBI chr11:20,363,714...20,383,782
Ensembl chr11:20,363,685...20,383,782

G

HIV-1 Tat specific factor 1

decreases expression

Gold results in decreased expression of HTATSF1 mRNA

NCBI chr X:136,497,229...136,512,346
Ensembl chr X:136,497,079...136,512,346

G

HtrA serine peptidase 4

decreases expression

Gold analog results in decreased expression of HTRA4 mRNA

NCBI chr 8:38,974,228...38,988,663
Ensembl chr 8:38,974,228...38,988,663

G

hypoxia up-regulated 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of HYOU1 mRNA

NCBI chr11:119,044,188...119,057,205
Ensembl chr11:119,044,188...119,057,227

G

isocitrate dehydrogenase (NADP(+)) 1

multiple interactions

Gold analog results in decreased expression of and results in increased phosphorylation of IDH1 protein

NCBI chr 2:208,236,227...208,255,071
Ensembl chr 2:208,236,229...208,266,074

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of IDH3G mRNA

NCBI chr X:153,785,768...153,794,375
Ensembl chr X:153,785,766...153,794,512

G

interferon gamma receptor 1

increases expression

Gold results in increased expression of IFNGR1 mRNA

NCBI chr 6:137,197,484...137,219,385
Ensembl chr 6:137,197,483...137,219,449

G

insulin like growth factor 1

multiple interactions

Gold inhibits the reaction [IGF1 protein binds to IGF1R protein]

NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744

G

insulin like growth factor 1 receptor

multiple interactions

Gold inhibits the reaction [IGF1 protein binds to IGF1R protein]; Gold inhibits the reaction [IGF2 protein binds to IGF1R protein]

NCBI chr15:98,648,539...98,964,530
Ensembl chr15:98,648,539...98,964,530

G

insulin like growth factor 2

multiple interactions

Gold inhibits the reaction [IGF2 protein binds to IGF1R protein]

NCBI chr11:2,129,117...2,149,566
Ensembl chr11:2,129,112...2,158,391

G

IKAROS family zinc finger 2

decreases expression

Gold results in decreased expression of IKZF2 mRNA

NCBI chr 2:212,999,698...213,152,456
Ensembl chr 2:212,999,691...213,152,427

G

interleukin 10

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of IL10 protein
Gold results in increased secretion of IL10 protein

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 1 alpha

multiple interactions
decreases expression
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of IL1A protein
Gold analog results in decreased expression of IL1A mRNA
Gold results in increased secretion of IL1A protein

PMID:22155353 PMID:36057382

NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493

G

interleukin 1 beta

multiple interactions
decreases expression
increases secretion

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL1B mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of IL1B protein
Gold analog results in decreased expression of IL1B mRNA
Gold results in increased secretion of IL1B protein

PMID:19695318 PMID:22155353 PMID:36057382

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 4

decreases expression

Gold analog results in decreased expression of IL4 mRNA

NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678

G

interleukin 6

multiple interactions
increases secretion

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL6 mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of IL6 protein
[Polyethylene Glycols binds to Gold] which results in increased expression of IL6 protein; [Polyethyleneimine binds to Gold] which results in increased expression of IL6 protein; [Thioctic Acid binds to Gold] which results in increased expression of IL6 protein
Gold results in increased secretion of IL6 protein

PMID:19695318 PMID:22155353 PMID:28433809

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

interleukin 6 receptor

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL6RA mRNA

NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450

G

inositol monophosphatase 1

decreases expression

Gold results in decreased expression of IMPA1 mRNA

NCBI chr 8:81,656,914...81,686,325
Ensembl chr 8:81,656,914...81,686,331

G

inositol polyphosphate multikinase

decreases expression

Gold results in decreased expression of IPMK mRNA

NCBI chr10:58,191,517...58,267,894
Ensembl chr10:58,191,517...58,267,894

G

IQ motif containing GTPase activating protein 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of IQGAP2 mRNA

NCBI chr 5:76,403,285...76,708,132
Ensembl chr 5:76,403,285...76,708,132

G

jagged canonical Notch ligand 1

decreases expression

Gold analog results in decreased expression of JAG1 mRNA

NCBI chr20:10,637,684...10,673,999
Ensembl chr20:10,637,684...10,673,999

G

Janus kinase 2

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of JAK2 protein

NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048

G

junction plakoglobin

decreases expression

Gold analog results in decreased expression of JUP protein

NCBI chr17:41,754,609...41,786,711
Ensembl chr17:41,754,604...41,786,931

G

ketohexokinase

increases expression

Gold analog results in increased expression of KHK mRNA

NCBI chr 2:27,086,772...27,100,762
Ensembl chr 2:27,086,772...27,100,762

G

Kin17 DNA and RNA binding protein

decreases expression

Gold results in decreased expression of KIN mRNA

NCBI chr10:7,750,962...7,787,993
Ensembl chr10:7,750,962...7,787,993

G

KIT ligand

decreases expression

Gold results in decreased expression of KITLG mRNA

NCBI chr12:88,492,793...88,580,471
Ensembl chr12:88,492,793...88,580,851

G

KRR1 small subunit processome component homolog

decreases expression

Gold results in decreased expression of KRR1 mRNA

NCBI chr12:75,490,863...75,511,609
Ensembl chr12:75,490,863...75,511,636

G

kynureninase

increases expression

Gold results in increased expression of KYNU mRNA

NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833

G

laccase domain containing 1

increases expression

Gold results in increased expression of LACC1 mRNA

NCBI chr13:43,879,178...43,893,932
Ensembl chr13:43,879,284...43,893,932

G

lactamase beta 2

decreases expression

Gold results in decreased expression of LACTB2 mRNA

NCBI chr 8:70,637,266...70,669,185
Ensembl chr 8:70,635,318...70,669,185

G

La ribonucleoprotein 1B

decreases expression

Gold results in decreased expression of LARP1B mRNA

NCBI chr 4:128,060,789...128,222,926
Ensembl chr 4:128,061,286...128,222,931

G

LIF interleukin 6 family cytokine

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of LIF protein
Gold results in increased secretion of LIF protein

NCBI chr22:30,240,453...30,246,759
Ensembl chr22:30,240,453...30,246,759

G

DNA ligase 4

multiple interactions

[Polyethyleneimine binds to Gold] which affects the expression of LIG4 mRNA

NCBI chr13:108,207,442...108,218,349
Ensembl chr13:108,207,439...108,218,368

G

LIM domain and actin binding 1

decreases expression

Gold results in decreased expression of LIMA1 mRNA

NCBI chr12:50,175,788...50,283,520
Ensembl chr12:50,175,788...50,283,520

G

lectin, mannose binding 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of LMAN1 mRNA

NCBI chr18:59,327,823...59,359,265
Ensembl chr18:59,327,823...59,359,265

G

lamin A/C

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of LMNA mRNA

NCBI chr 1:156,082,573...156,140,081
Ensembl chr 1:156,082,572...156,140,081

G

lamin B1

increases degradation

Gold analog results in increased degradation of LMNB1 protein

NCBI chr 5:126,776,623...126,837,020
Ensembl chr 5:126,776,623...126,837,020

G

lysophosphatidylglycerol acyltransferase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of LPGAT1 mRNA

NCBI chr 1:211,743,457...211,830,763
Ensembl chr 1:211,743,457...211,830,763

G

LRAT domain containing 1

increases expression

Gold results in increased expression of LRATD1 mRNA

NCBI chr 2:14,632,717...14,651,916
Ensembl chr 2:14,632,700...14,650,814

G

LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

Gold results in decreased expression of LSM5 mRNA

NCBI chr 7:32,485,338...32,495,283
Ensembl chr 7:32,485,338...32,495,283

G

LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

Gold results in decreased expression of LSM6 mRNA

NCBI chr 4:146,175,718...146,191,535
Ensembl chr 4:146,175,703...146,200,000

G

lanosterol synthase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of LSS mRNA

NCBI chr21:46,188,446...46,228,774
Ensembl chr21:46,188,141...46,228,824

G

mitotic arrest deficient 2 like 1

decreases expression

Gold results in decreased expression of MAD2L1 mRNA

NCBI chr 4:120,055,623...120,066,848
Ensembl chr 4:120,055,623...120,066,858

G

microtubule associated protein 1B

increases expression

Gold results in increased expression of MAP1B mRNA

NCBI chr 5:72,107,475...72,209,565
Ensembl chr 5:72,107,234...72,209,565

G

mitogen-activated protein kinase kinase 1

multiple interactions

MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656

G

muscleblind like splicing regulator 2

decreases expression

Gold results in decreased expression of MBNL2 mRNA

NCBI chr13:97,141,834...97,394,120
Ensembl chr13:97,221,434...97,394,120

G

malate dehydrogenase 1B

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of MDH1B mRNA
Gold analog results in decreased expression of MDH1B mRNA

PMID:28433809 PMID:36057382

NCBI chr 2:206,737,763...206,765,328
Ensembl chr 2:206,737,763...206,765,328

G

MDM2 proto-oncogene

decreases expression

Gold analog results in decreased expression of MDM2 mRNA

NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544

G

mitochondrial trans-2-enoyl-CoA reductase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MECR mRNA

NCBI chr 1:29,167,696...29,230,934
Ensembl chr 1:29,192,657...29,230,942

G

MEFV innate immunity regulator, pyrin

increases expression

Gold results in increased expression of MEFV mRNA

NCBI chr16:3,242,027...3,256,633
Ensembl chr16:3,242,027...3,256,633

G

methionyl aminopeptidase 2

decreases expression

Gold analog results in decreased expression of METAP2 mRNA; Gold results in decreased expression of METAP2 mRNA

PMID:25523186 PMID:36057382

NCBI chr12:95,474,152...95,515,839
Ensembl chr12:95,473,520...95,515,839

G

marker of proliferation Ki-67

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in increased expression of MKI67 mRNA
Gold analog results in decreased expression of MKI67 mRNA

PMID:28433809 PMID:36057382

NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423

G

membrane magnesium transporter 1

decreases expression

Gold results in decreased expression of MMGT1 mRNA

NCBI chr X:135,960,588...135,973,988
Ensembl chr X:135,960,588...135,974,029

G

matrix metallopeptidase 3

increases expression

Gold results in increased expression of MMP3 mRNA

NCBI chr11:102,835,801...102,843,609
Ensembl chr11:102,835,801...102,843,609

G

matrix metallopeptidase 9

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]

NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561

G

MNAT1 component of CDK activating kinase

decreases expression

Gold results in decreased expression of MNAT1 mRNA

NCBI chr14:60,734,761...60,969,965
Ensembl chr14:60,734,742...60,969,965

G

MOB kinase activator 1B

decreases expression

Gold results in decreased expression of MOB1B mRNA

NCBI chr 4:70,901,851...70,988,168
Ensembl chr 4:70,902,326...71,022,449

G

MOB family member 4, phocein

decreases expression

Gold results in decreased expression of MOB4 mRNA

NCBI chr 2:197,515,554...197,553,699
Ensembl chr 2:197,515,571...197,553,699

G

MORC family CW-type zinc finger 3

decreases expression

Gold results in decreased expression of MORC3 mRNA

NCBI chr21:36,320,197...36,376,632
Ensembl chr21:36,320,189...36,386,148

G

mitochondrial ribosomal protein L3

decreases expression

Gold results in decreased expression of MRPL3 mRNA

NCBI chr 3:131,462,212...131,502,971
Ensembl chr 3:131,462,212...131,502,983

G

mitochondrial ribosomal protein S6

decreases expression

Gold results in decreased expression of MRPS6 mRNA

NCBI chr21:34,073,578...34,143,030
Ensembl chr21:34,073,224...34,362,252

G

metallothionein 1B

increases expression

Gold results in increased expression of MT1B mRNA

NCBI chr16:56,651,886...56,653,204
Ensembl chr16:56,651,886...56,653,204

G

metallothionein 1E

increases expression

Gold results in increased expression of MT1E mRNA

NCBI chr16:56,625,781...56,627,112
Ensembl chr16:56,625,475...56,627,112

G

metallothionein 1F

increases expression

Gold results in increased expression of MT1F mRNA

NCBI chr16:56,657,959...56,659,303
Ensembl chr16:56,657,731...56,660,698

G

metallothionein 1H

increases expression

Gold results in increased expression of MT1H mRNA

NCBI chr16:56,669,814...56,671,129
Ensembl chr16:56,669,814...56,671,129

G

metallothionein 1L (pseudogene)

increases expression

Gold results in increased expression of MT1L mRNA

NCBI chr16:56,617,461...56,618,818
Ensembl chr16:56,617,563...56,618,680

G

metallothionein 1X

increases expression

Gold results in increased expression of MT1X mRNA

NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196

G

metallothionein 2A

increases expression

Gold results in increased expression of MT2A mRNA

NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497

G

methylenetetrahydrofolate reductase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MTHFR mRNA

NCBI chr 1:11,785,723...11,805,964
Ensembl chr 1:11,785,723...11,806,455

G

myotubularin related protein 6

decreases expression

Gold results in decreased expression of MTMR6 mRNA

NCBI chr13:25,246,222...25,287,488
Ensembl chr13:25,246,222...25,287,510

G

mechanistic target of rapamycin kinase

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of MTOR protein

NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556

G

MTSS I-BAR domain containing 1

increases expression

Gold results in increased expression of MTSS1 mRNA

NCBI chr 8:124,550,784...124,728,473
Ensembl chr 8:124,550,784...124,728,473

G

microsomal triglyceride transfer protein

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of MTTP mRNA

NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,564,081...99,623,997

G

MYCL proto-oncogene, bHLH transcription factor

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MYCL mRNA

NCBI chr 1:39,895,428...39,901,917
Ensembl chr 1:39,895,428...39,902,256

G

myoneurin

decreases expression

Gold results in decreased expression of MYNN mRNA

NCBI chr 3:169,773,396...169,789,716
Ensembl chr 3:169,773,396...169,789,716

G

N-acyl phosphatidylethanolamine phospholipase D

decreases expression

Gold results in decreased expression of NAPEPLD mRNA

NCBI chr 7:103,099,776...103,150,001
Ensembl chr 7:103,099,776...103,149,560

G

neutral cholesterol ester hydrolase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of NCEH1 mRNA

NCBI chr 3:172,630,249...172,711,067
Ensembl chr 3:172,630,249...172,711,218

G

NFE2 like bZIP transcription factor 2

increases activity
increases expression

Gold results in increased activity of NFE2L2 promoter
Gold analog results in increased expression of NFE2L2 mRNA; Gold analog results in increased expression of NFE2L2 protein

PMID:21643505 PMID:36057382

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nuclear factor kappa B subunit 1

decreases expression

Gold analog results in decreased expression of NFKB1 mRNA

NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302

G

NFKB inhibitor delta

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of NFKBID mRNA

NCBI chr19:35,887,952...35,902,303
Ensembl chr19:35,887,630...35,902,303

G

NFKB inhibitor zeta

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of NFKBIZ mRNA

NCBI chr 3:101,827,990...101,861,022
Ensembl chr 3:101,827,991...101,861,022

G

NIPBL cohesin loading factor

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of NIPBL mRNA

NCBI chr 5:36,876,769...37,066,413
Ensembl chr 5:36,876,769...37,066,413

G

nitric oxide synthase 2

increases expression

Gold results in increased expression of NOS2 protein

NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529

G

NPL4 homolog, ubiquitin recognition factor

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of NPLOC4 mRNA

NCBI chr17:81,556,885...81,637,112
Ensembl chr17:81,556,887...81,648,465

G

nucleophosmin 1

decreases expression

Gold results in decreased expression of NPM1 mRNA

NCBI chr 5:171,387,116...171,410,900
Ensembl chr 5:171,387,116...171,411,810

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

[Polyethyleneimine binds to Gold] which results in increased expression of NQO1 mRNA
Gold analog results in increased expression of NQO1 mRNA; Gold results in increased expression of NQO1 mRNA

PMID:28433809 PMID:29705079 PMID:36057382

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

nuclear receptor subfamily 0 group B member 2

decreases expression

Gold analog results in decreased expression of NR0B2 mRNA

NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975

G

nuclear receptor subfamily 4 group A member 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of NR4A1 mRNA

NCBI chr12:52,022,832...52,059,503
Ensembl chr12:52,022,832...52,059,507

G

neuronal cell adhesion molecule

increases expression

Gold results in increased expression of NRCAM mRNA

NCBI chr 7:108,147,649...108,456,720
Ensembl chr 7:108,147,623...108,456,717

G

nuclear receptor interacting protein 1

increases expression

Gold results in increased expression of NRIP1 mRNA

NCBI chr21:14,961,235...15,065,936
Ensembl chr21:14,961,235...15,065,936

G

netrin 4

increases expression

Gold results in increased expression of NTN4 mRNA

NCBI chr12:95,657,807...95,791,155
Ensembl chr12:95,657,807...95,791,189

G

nucleobindin 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of NUCB1 mRNA

NCBI chr19:48,900,312...48,923,372
Ensembl chr19:48,900,050...48,923,473

G

nudix hydrolase 1

decreases expression

Gold analog results in decreased expression of NUDT1 mRNA

NCBI chr 7:2,242,226...2,251,145
Ensembl chr 7:2,242,226...2,251,146

G

nudix hydrolase 12

decreases expression

Gold results in decreased expression of NUDT12 mRNA

NCBI chr 5:103,548,855...103,562,789
Ensembl chr 5:103,548,855...103,562,790

G

nudix hydrolase 13

decreases expression

Gold analog results in decreased expression of NUDT13 mRNA

NCBI chr10:73,110,455...73,131,823
Ensembl chr10:73,110,375...73,131,828

G

nucleoporin 210

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of NUP210 mRNA

NCBI chr 3:13,316,235...13,420,322
Ensembl chr 3:13,316,235...13,420,322

G

ORC ubiquitin ligase 1

decreases expression

Gold results in decreased expression of OBI1 mRNA

NCBI chr13:78,614,289...78,659,155
Ensembl chr13:78,614,289...78,659,155

G

odr-4 GPCR localization factor homolog

decreases expression

Gold results in decreased expression of ODR4 mRNA

NCBI chr 1:186,375,838...186,435,031
Ensembl chr 1:186,375,838...186,421,378

G

oxoglutarate dehydrogenase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of OGDH mRNA

NCBI chr 7:44,606,627...44,709,066
Ensembl chr 7:44,606,572...44,709,066

G

8-oxoguanine DNA glycosylase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of OGG1 mRNA

NCBI chr 3:9,749,952...9,783,108
Ensembl chr 3:9,749,944...9,788,219

G

origin recognition complex subunit 4

decreases expression

Gold results in decreased expression of ORC4 mRNA

NCBI chr 2:147,930,396...148,021,551
Ensembl chr 2:147,930,396...148,021,604

G

OS9 endoplasmic reticulum lectin

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of OS9 mRNA

NCBI chr12:57,694,132...57,721,557
Ensembl chr12:57,693,841...57,728,342

G

oxidative stress induced growth inhibitor 1

increases expression

Gold results in increased expression of OSGIN1 mRNA

NCBI chr16:83,953,240...83,966,332
Ensembl chr16:83,931,311...83,966,332

G

prolyl 4-hydroxylase subunit beta

decreases expression

Gold analog results in decreased expression of P4HB protein

NCBI chr17:81,843,166...81,860,535
Ensembl chr17:81,843,159...81,860,856

G

poly(ADP-ribose) polymerase 1

multiple interactions
decreases expression

Organogold Compounds promotes the reaction [Gold binds to PARP1 protein]
Gold analog results in decreased expression of PARP1 mRNA

PMID:21370912 PMID:36057382

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

poly(rC) binding protein 1

decreases expression

Gold analog results in decreased expression of PCBP1 protein

NCBI chr 2:70,087,477...70,089,203
Ensembl chr 2:70,087,477...70,089,203

G

propionyl-CoA carboxylase subunit alpha

decreases expression

Gold analog results in decreased expression of PCCA mRNA

NCBI chr13:100,089,093...100,530,435
Ensembl chr13:100,089,015...100,530,437

G

polycomb group ring finger 5

decreases expression

Gold results in decreased expression of PCGF5 mRNA

NCBI chr10:91,156,219...91,284,337
Ensembl chr10:91,163,012...91,284,337

G

polycomb group ring finger 6

decreases expression

Gold results in decreased expression of PCGF6 mRNA

NCBI chr10:103,302,796...103,351,140
Ensembl chr10:103,302,796...103,351,144

G

proliferating cell nuclear antigen

decreases expression

Gold analog results in decreased expression of PCNA mRNA

NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626

G

phosphodiesterase 4B

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PDE4B mRNA

NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579

G

period circadian regulator 3

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of PER3 mRNA

NCBI chr 1:7,784,291...7,845,177
Ensembl chr 1:7,784,291...7,845,177

G

phosphatidylinositol glycan anchor biosynthesis class A

decreases expression

Gold results in decreased expression of PIGA mRNA

NCBI chr X:15,319,451...15,335,554
Ensembl chr X:15,319,452...15,335,554

G

phosphatidylinositol glycan anchor biosynthesis class F

decreases expression

Gold results in decreased expression of PIGF mRNA

NCBI chr 2:46,580,937...46,617,041
Ensembl chr 2:46,580,937...46,617,055

G

phosphatidylinositol glycan anchor biosynthesis class K

decreases expression

Gold results in decreased expression of PIGK mRNA

NCBI chr 1:77,088,989...77,219,430
Ensembl chr 1:77,088,989...77,219,430

G

phosphatidylinositol glycan anchor biosynthesis class Y

decreases expression

Gold results in decreased expression of PIGY mRNA

NCBI chr 4:88,520,998...88,523,776
Ensembl chr 4:88,520,998...88,523,776

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PIK3R1 mRNA

NCBI chr 5:68,215,756...68,301,821
Ensembl chr 5:68,215,740...68,301,821

G

pyruvate kinase M1/2

decreases expression

Gold analog results in decreased expression of PKM protein

NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819

G

phospholipase A2 group VI

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PLA2G6 mRNA

NCBI chr22:38,111,495...38,181,830
Ensembl chr22:38,111,495...38,214,778

G

pleckstrin homology and FYVE domain containing 2

decreases expression

Gold results in decreased expression of PLEKHF2 mRNA

NCBI chr 8:95,133,785...95,156,685
Ensembl chr 8:95,115,642...95,156,698

G

perilipin 3

increases expression

Gold analog results in increased expression of PLIN3 protein

NCBI chr19:4,838,341...4,867,667
Ensembl chr19:4,838,341...4,867,694

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PMAIP1 mRNA

NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,996...59,904,305

G

pancreatic lipase related protein 3

increases expression

Gold results in increased expression of PNLIPRP3 mRNA

NCBI chr10:116,427,847...116,477,957
Ensembl chr10:116,427,847...116,477,957

G

DNA polymerase kappa

decreases expression

Gold results in decreased expression of POLK mRNA

NCBI chr 5:75,510,774...75,609,991
Ensembl chr 5:75,511,845...75,609,991

G

RNA polymerase II, I and III subunit K

decreases expression

Gold results in decreased expression of POLR2K mRNA

NCBI chr 8:100,150,636...100,154,003
Ensembl chr 8:100,150,623...100,154,003

G

popeye domain cAMP effector 1

increases expression

Gold results in increased expression of POPDC1 mRNA

NCBI chr 6:105,096,822...105,137,157
Ensembl chr 6:105,096,822...105,137,157

G

popeye domain cAMP effector 3

increases expression

Gold results in increased expression of POPDC3 mRNA

NCBI chr 6:105,157,900...105,180,014
Ensembl chr 6:105,157,900...105,180,014

G

cytochrome p450 oxidoreductase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of POR mRNA

NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855

G

protein phosphatase 1 catalytic subunit beta

decreases expression

Gold results in decreased expression of PPP1CB mRNA

NCBI chr 2:28,751,604...28,802,940
Ensembl chr 2:28,751,640...28,802,940

G

protein phosphatase 2 scaffold subunit Aalpha

decreases expression

Gold analog results in decreased expression of PPP2R1A protein

NCBI chr19:52,190,052...52,229,518
Ensembl chr19:52,170,936...52,229,518

G

protein phosphatase 2 regulatory subunit B'epsilon

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of PPP2R5E mRNA

NCBI chr14:63,371,364...63,543,377
Ensembl chr14:63,371,364...63,543,377

G

peroxiredoxin 1

decreases expression
increases expression

Gold analog results in decreased expression of PRDX1 protein
Gold analog results in increased expression of PRDX1 mRNA

PMID:24780912 PMID:36057382

NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732

G

proline rich coiled-coil 2A

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of PRRC2A mRNA

NCBI chr 6:31,620,715...31,637,771
Ensembl chr 6:31,620,715...31,637,771

G

phosphoserine aminotransferase 1

decreases expression

Gold analog results in decreased expression of PSAT1 protein

NCBI chr 9:78,297,125...78,330,093
Ensembl chr 9:78,297,125...78,330,093

G

proteasome 26S subunit, non-ATPase 14

decreases expression

Gold results in decreased expression of PSMD14 mRNA

NCBI chr 2:161,308,425...161,411,717
Ensembl chr 2:161,308,425...161,411,717

G

polypyrimidine tract binding protein 2

decreases expression

Gold results in decreased expression of PTBP2 mRNA

NCBI chr 1:96,721,784...96,823,739
Ensembl chr 1:96,721,665...96,823,738

G

prostaglandin reductase 1

increases expression

Gold results in increased expression of PTGR1 mRNA

NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893

G

prostaglandin reductase 2

decreases expression

Gold results in decreased expression of PTGR2 mRNA

NCBI chr14:73,851,831...73,885,726
Ensembl chr14:73,851,831...73,885,726

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

[Gold co-treated with Silicon Dioxide] results in increased expression of PTGS2 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of PTGS2 mRNA
Gold results in increased expression of PTGS2 mRNA

PMID:22155353 PMID:28433809

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

protein tyrosine phosphatase receptor type C

increases expression

Gold analog results in increased expression of PTPRC mRNA

NCBI chr 1:198,638,713...198,757,476
Ensembl chr 1:198,638,457...198,759,342

G

6-pyruvoyltetrahydropterin synthase

decreases expression

Gold results in decreased expression of PTS mRNA

NCBI chr11:112,226,428...112,233,973
Ensembl chr11:112,226,367...112,269,955

G

PVR cell adhesion molecule

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of PVR mRNA

NCBI chr19:44,643,910...44,666,162
Ensembl chr19:44,643,798...44,666,162

G

RAB11A, member RAS oncogene family

decreases expression

Gold results in decreased expression of RAB11A mRNA

NCBI chr15:65,869,491...65,891,989
Ensembl chr15:65,726,054...65,891,989

G

RAB18, member RAS oncogene family

decreases expression

Gold results in decreased expression of RAB18 mRNA

NCBI chr10:27,504,304...27,542,239
Ensembl chr10:27,504,174...27,545,117

G

Rab geranylgeranyltransferase subunit beta

decreases expression

Gold results in decreased expression of RABGGTB mRNA

NCBI chr 1:75,786,194...75,795,090
Ensembl chr 1:75,786,197...75,795,086

G

RAD51 recombinase

decreases expression

Gold analog results in decreased expression of RAD51 mRNA

NCBI chr15:40,694,733...40,732,340
Ensembl chr15:40,694,774...40,732,340

G

RAD51 paralog B

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RAD51B mRNA

NCBI chr14:67,819,779...68,683,096
Ensembl chr14:67,819,779...68,730,218

G

retinoic acid induced 14

increases expression

Gold results in increased expression of RAI14 mRNA

NCBI chr 5:34,656,328...34,832,612
Ensembl chr 5:34,656,328...34,832,612

G

RB1 inducible coiled-coil 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RB1CC1 mRNA

NCBI chr 8:52,622,458...52,714,435
Ensembl chr 8:52,622,458...52,745,843

G

RNA binding motif protein 12

decreases expression

Gold results in decreased expression of RBM12 mRNA

NCBI chr20:35,648,925...35,664,900
Ensembl chr20:35,648,925...35,664,956

G

retinol binding protein 1

increases expression

Gold results in increased expression of RBP1 mRNA

NCBI chr 3:139,517,438...139,539,742
Ensembl chr 3:139,517,434...139,539,829

G

ring finger and CCCH-type domains 1

decreases expression

Gold results in decreased expression of RC3H1 mRNA

NCBI chr 1:173,931,084...174,022,357
Ensembl chr 1:173,931,084...174,022,357

G

radixin

decreases expression

Gold analog results in decreased expression of RDX mRNA

NCBI chr11:110,174,922...110,296,614
Ensembl chr11:109,864,295...110,296,712

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

riboflavin kinase

decreases expression

Gold results in decreased expression of RFK mRNA

NCBI chr 9:76,385,526...76,394,426
Ensembl chr 9:76,385,526...76,394,517

G

ras homolog family member U

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RHOU mRNA

NCBI chr 1:228,644,647...228,746,669
Ensembl chr 1:228,735,479...228,746,664

G

ring finger protein 11

decreases expression

Gold results in decreased expression of RNF11 mRNA

NCBI chr 1:51,236,273...51,273,447
Ensembl chr 1:51,236,273...51,273,447

G

ring finger protein 13

decreases expression

Gold results in decreased expression of RNF13 mRNA

NCBI chr 3:149,812,688...149,962,139
Ensembl chr 3:149,812,770...149,962,139

G

ring finger protein 138

decreases expression

Gold results in decreased expression of RNF138 mRNA

NCBI chr18:32,091,874...32,131,561
Ensembl chr18:32,091,874...32,131,561

G

ring finger protein 149

decreases expression

Gold results in decreased expression of RNF149 mRNA

NCBI chr 2:101,271,219...101,308,701
Ensembl chr 2:101,271,219...101,308,701

G

ring finger protein 2

decreases expression

Gold results in decreased expression of RNF2 mRNA

NCBI chr 1:185,045,558...185,102,603
Ensembl chr 1:185,045,497...185,102,603

G

ring finger protein, transmembrane 1

decreases expression

Gold results in decreased expression of RNFT1 mRNA

NCBI chr17:59,952,240...59,964,740
Ensembl chr17:59,952,240...59,964,761

G

Ro60, Y RNA binding protein

decreases expression

Gold results in decreased expression of RO60 mRNA

NCBI chr 1:193,059,612...193,091,777
Ensembl chr 1:193,059,454...193,091,777

G

RP2 activator of ARL3 GTPase

decreases expression

Gold results in decreased expression of RP2 mRNA

NCBI chr X:46,837,043...46,882,358
Ensembl chr X:46,837,043...46,882,358

G

ribosomal protein S27 like

decreases expression

Gold results in decreased expression of RPS27L mRNA

NCBI chr15:63,148,249...63,157,477
Ensembl chr15:63,125,872...63,158,021

G

ribosomal protein S6 kinase B1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased expression of RPS6KB1 protein

NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574

G

reticulon 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of RTN4 mRNA

NCBI chr 2:54,972,189...55,137,831
Ensembl chr 2:54,972,187...55,112,621

G

serum amyloid A1

increases expression
multiple interactions

Gold results in increased expression of SAA1 mRNA
Gold promotes the reaction [SAA1 protein binds to TLR2 protein]

NCBI chr11:18,266,264...18,269,967
Ensembl chr11:18,266,260...18,269,977

G

secretion associated Ras related GTPase 1B

decreases expression

Gold results in decreased expression of SAR1B mRNA

NCBI chr 5:134,601,149...134,632,828
Ensembl chr 5:134,601,149...134,649,271

G

SAP domain containing ribonucleoprotein

decreases expression

Gold results in decreased expression of SARNP mRNA

NCBI chr12:55,752,463...55,817,724
Ensembl chr12:55,752,463...55,817,724

G

short coiled-coil protein

decreases expression

Gold results in decreased expression of SCOC mRNA

NCBI chr 4:140,257,308...140,385,728
Ensembl chr 4:140,257,286...140,385,728

G

sterol carrier protein 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of SCP2 mRNA

NCBI chr 1:52,927,276...53,051,698
Ensembl chr 1:52,927,276...53,051,698

G

SEC23 homolog A, COPII coat complex component

decreases expression

Gold results in decreased expression of SEC23A mRNA

NCBI chr14:39,031,919...39,103,235
Ensembl chr14:39,031,919...39,109,646

G

SEC24 homolog A, COPII coat complex component

decreases expression

Gold results in decreased expression of SEC24A mRNA

NCBI chr 5:134,648,382...134,727,909
Ensembl chr 5:134,648,785...134,727,909

G

SEL1L family member 3

increases expression

Gold results in increased expression of SEL1L3 mRNA

NCBI chr 4:25,713,964...25,863,566
Ensembl chr 4:25,747,433...25,863,760

G

selenoprotein T

decreases expression

Gold results in decreased expression of SELENOT mRNA

NCBI chr 3:150,603,321...150,630,436
Ensembl chr 3:150,602,875...150,630,436

G

septin 8

decreases expression

Gold analog results in decreased expression of SEPTIN8 protein

NCBI chr 5:132,750,819...132,780,083
Ensembl chr 5:132,750,819...132,807,241

G

stress associated endoplasmic reticulum protein 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of SERP1 mRNA

NCBI chr 3:150,541,998...150,546,496
Ensembl chr 3:150,541,998...150,603,228

G

serpin family E member 1

increases expression

Gold results in increased expression of SERPINE1 mRNA

NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247

G

serpin family H member 1

decreases expression

Gold analog results in decreased expression of SERPINH1 protein

NCBI chr11:75,562,253...75,572,783
Ensembl chr11:75,562,056...75,572,783

G

SH3 domain containing kinase binding protein 1

increases expression

Gold results in increased expression of SH3KBP1 mRNA

NCBI chr X:19,533,977...19,887,600
Ensembl chr X:19,533,977...19,887,600

G

solute carrier family 25 member 24

decreases expression

Gold analog results in decreased expression of SLC25A24 protein

NCBI chr 1:108,134,043...108,200,343
Ensembl chr 1:108,134,043...108,200,849

G

SRA stem-loop interacting RNA binding protein

decreases expression

Gold results in decreased expression of SLIRP mRNA

NCBI chr14:77,708,071...77,717,598
Ensembl chr14:77,708,071...77,761,104

G

SNF2 related chromatin remodeling ATPase with DExD box 1

decreases expression

Gold results in decreased expression of SMARCAD1 mRNA

NCBI chr 4:94,207,608...94,291,292
Ensembl chr 4:94,207,611...94,291,292

G

structural maintenance of chromosomes 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SMC4 mRNA

NCBI chr 3:160,399,650...160,434,953
Ensembl chr 3:160,399,274...160,434,954

G

structural maintenance of chromosomes 6

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SMC6 mRNA

NCBI chr 2:17,663,812...17,753,810
Ensembl chr 2:17,663,812...17,800,242

G

small nuclear ribonucleoprotein polypeptide B2

decreases expression

Gold results in decreased expression of SNRPB2 mRNA

NCBI chr20:16,730,026...16,742,564
Ensembl chr20:16,729,961...16,742,564

G

sorting nexin 6

decreases expression

Gold results in decreased expression of SNX6 mRNA

NCBI chr14:34,561,093...34,630,148
Ensembl chr14:34,561,093...34,630,160

G

superoxide dismutase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SOD1 mRNA

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

SP100 nuclear antigen

decreases expression

Gold results in decreased expression of SP100 mRNA

NCBI chr 2:230,416,201...230,545,606
Ensembl chr 2:230,415,942...230,545,606

G

Sp3 transcription factor

decreases expression

Gold results in decreased expression of SP3 mRNA

NCBI chr 2:173,900,775...173,965,702
Ensembl chr 2:173,880,850...173,965,373

G

spastin

decreases expression

Gold results in decreased expression of SPAST mRNA

NCBI chr 2:32,063,556...32,157,637
Ensembl chr 2:32,063,556...32,157,637

G

spermatogenesis associated 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of SPATA2 mRNA

NCBI chr20:49,903,391...49,915,529
Ensembl chr20:49,903,391...49,915,529

G

sterol regulatory element binding transcription factor 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of SREBF1 mRNA
Gold analog results in decreased expression of SREBF1 mRNA

PMID:28433809 PMID:36057382

NCBI chr17:17,811,334...17,836,986
Ensembl chr17:17,810,399...17,837,002

G

SREK1 interacting protein 1

decreases expression

Gold results in decreased expression of SREK1IP1 mRNA

NCBI chr 5:64,718,148...64,768,691
Ensembl chr 5:64,718,148...64,768,691

G

signal recognition particle 9

decreases expression

Gold results in decreased expression of SRP9 mRNA

NCBI chr 1:225,777,826...225,790,464
Ensembl chr 1:225,777,813...225,790,468

G

serine and arginine rich splicing factor 10

decreases expression

Gold results in decreased expression of SRSF10 mRNA

NCBI chr 1:23,964,347...23,980,327
Ensembl chr 1:23,964,347...23,980,927

G

serine and arginine rich splicing factor 3

decreases expression

Gold results in decreased expression of SRSF3 mRNA

NCBI chr 6:36,594,362...36,605,600
Ensembl chr 6:36,594,353...36,605,911

G

serine and arginine rich splicing factor 7

decreases expression

Gold results in decreased expression of SRSF7 mRNA

NCBI chr 2:38,743,599...38,751,494
Ensembl chr 2:38,743,599...38,751,494

G

signal transducer and activator of transcription 1

multiple interactions
increases expression

[Gold co-treated with Silicon Dioxide] results in increased expression of STAT1 mRNA
Gold results in increased expression of STAT1 mRNA

NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960

G

signal transducer and activator of transcription 3

increases expression
multiple interactions

Gold results in increased expression of STAT3 mRNA
[Gold co-treated with Silicon Dioxide] results in increased expression of STAT3 mRNA

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

staufen double-stranded RNA binding protein 2

decreases expression

Gold results in decreased expression of STAU2 mRNA

NCBI chr 8:73,420,369...73,747,480
Ensembl chr 8:73,420,369...73,747,708

G

starch binding domain 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of STBD1 mRNA

NCBI chr 4:76,306,733...76,311,130
Ensembl chr 4:76,306,733...76,311,130

G

STEAP family member 1

decreases expression

Gold results in decreased expression of STEAP1 mRNA

NCBI chr 7:90,154,469...90,164,827
Ensembl chr 7:90,154,456...90,164,829

G

serine/threonine kinase 26

decreases expression

Gold results in decreased expression of STK26 mRNA

NCBI chr X:132,023,302...132,075,943
Ensembl chr X:132,023,302...132,075,943

G

succinate-CoA ligase ADP-forming subunit beta

decreases expression

Gold analog results in decreased expression of SUCLA2 mRNA; Gold results in decreased expression of SUCLA2 mRNA

PMID:25523186 PMID:36057382

NCBI chr13:47,942,656...48,001,273
Ensembl chr13:47,745,736...48,037,968

G

synaptotagmin 1

decreases expression

Gold analog results in decreased expression of SYT1 mRNA

NCBI chr12:78,863,982...79,452,008
Ensembl chr12:78,863,993...79,452,008

G

synoviolin 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of SYVN1 mRNA

NCBI chr11:65,127,279...65,134,519
Ensembl chr11:65,121,780...65,134,532

G

tumor associated calcium signal transducer 2

increases expression

Gold results in increased expression of TACSTD2 mRNA

NCBI chr 1:58,575,433...58,577,252
Ensembl chr 1:58,575,433...58,577,252

G

transcriptional adaptor 1

decreases expression

Gold results in decreased expression of TADA1 mRNA

NCBI chr 1:166,856,510...166,876,264
Ensembl chr 1:166,856,510...166,876,264

G

TATA-box binding protein associated factor 9b

decreases expression

Gold results in decreased expression of TAF9B mRNA

NCBI chr X:78,129,748...78,139,650
Ensembl chr X:78,129,748...78,139,650

G

transgelin

decreases expression

Gold analog results in decreased expression of TAGLN mRNA

NCBI chr11:117,199,294...117,207,465
Ensembl chr11:117,199,370...117,207,464

G

TBL1X/Y related 1

decreases expression

Gold results in decreased expression of TBL1XR1 mRNA

NCBI chr 3:177,019,344...177,201,800
Ensembl chr 3:177,019,340...177,228,000

G

transcription elongation factor A1

decreases expression

Gold results in decreased expression of TCEA1 mRNA

NCBI chr 8:53,966,556...54,022,448
Ensembl chr 8:53,966,552...54,022,448

G

tryptophan 2,3-dioxygenase

decreases expression

Gold results in decreased expression of TDO2 mRNA

NCBI chr 4:155,903,696...155,920,406
Ensembl chr 4:155,854,738...155,920,406

G

testis expressed 30

decreases expression

Gold results in decreased expression of TEX30 mRNA

NCBI chr13:102,765,888...102,773,786
Ensembl chr13:102,765,888...102,773,811

G

transcription factor EC

decreases expression

Gold results in decreased expression of TFEC mRNA

NCBI chr 7:115,935,152...116,159,896
Ensembl chr 7:115,935,148...116,159,896

G

tissue factor pathway inhibitor 2

increases expression

Gold results in increased expression of TFPI2 mRNA

NCBI chr 7:93,885,396...93,890,753
Ensembl chr 7:93,885,396...93,890,753

G

transforming growth factor beta 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TGFB1 mRNA

NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922

G

THAP domain containing 1

decreases expression

Gold results in decreased expression of THAP1 mRNA

NCBI chr 8:42,836,674...42,843,325
Ensembl chr 8:42,836,674...42,843,325

G

TIA1 cytotoxic granule associated RNA binding protein

decreases expression

Gold results in decreased expression of TIA1 mRNA

NCBI chr 2:70,209,444...70,248,793
Ensembl chr 2:70,209,444...70,248,660

G

transketolase

decreases expression

Gold analog results in decreased expression of TKT protein

NCBI chr 3:53,224,712...53,256,022
Ensembl chr 3:53,224,712...53,256,052

G

tousled like kinase 1

increases expression

Gold results in increased expression of TLK1 mRNA

NCBI chr 2:170,990,823...171,231,293
Ensembl chr 2:170,990,823...171,231,314

G

toll like receptor 2

multiple interactions
increases expression

Gold promotes the reaction [SAA1 protein binds to TLR2 protein]
Gold results in increased expression of TLR2 mRNA

NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,050...153,706,260

G

transmembrane 4 L six family member 1

increases expression

Gold results in increased expression of TM4SF1 mRNA

NCBI chr 3:149,369,022...149,377,649
Ensembl chr 3:149,369,022...149,377,692

G

transmembrane p24 trafficking protein 10

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of TMED10 mRNA

NCBI chr14:75,131,469...75,176,612
Ensembl chr14:75,131,469...75,176,612

G

tumor necrosis factor

increases secretion
multiple interactions

Gold results in increased secretion of TNF protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of TNF protein

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

TNF alpha induced protein 3

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of TNFAIP3 mRNA

NCBI chr 6:137,866,349...137,883,312
Ensembl chr 6:137,867,214...137,883,314

G

TNF alpha induced protein 8 like 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFAIP8L1 mRNA

NCBI chr19:4,639,516...4,655,568
Ensembl chr19:4,639,516...4,655,568

G

TNF receptor superfamily member 10a

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFRSF10A mRNA

NCBI chr 8:23,190,452...23,225,102
Ensembl chr 8:23,190,452...23,225,102

G

TNF receptor superfamily member 1A

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFRSF1A mRNA

NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114

G

TNF superfamily member 10

decreases expression

Gold analog results in decreased expression of TNFSF10 mRNA

NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475

G

tumor protein p53

increases expression

Gold analog results in increased expression of TRP53 mRNA

NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546

G

tumor protein, translationally-controlled 1

decreases expression

Gold analog results in decreased expression of TPT1 protein

NCBI chr13:45,333,471...45,341,183
Ensembl chr13:45,333,471...45,341,284

G

tripartite motif containing 23

decreases expression

Gold results in decreased expression of TRIM23 mRNA

NCBI chr 5:65,589,690...65,624,333
Ensembl chr 5:65,589,690...65,625,975

G

tRNA methyltransferase 13 homolog

decreases expression

Gold results in decreased expression of TRMT13 mRNA

NCBI chr 1:100,133,163...100,150,496
Ensembl chr 1:100,133,150...100,150,496

G

TruB pseudouridine synthase family member 1

decreases expression

Gold results in decreased expression of TRUB1 mRNA

NCBI chr10:114,938,195...114,977,676
Ensembl chr10:114,938,195...114,977,676

G

tubulin alpha 1a

decreases expression

Gold analog results in decreased expression of TUBA1A protein

NCBI chr12:49,184,795...49,189,080
Ensembl chr12:49,184,686...49,189,324

G

tubulin beta class I

decreases expression

Gold analog results in decreased expression of TUBB5 protein

NCBI chr 6:30,720,352...30,725,422
Ensembl chr 6:30,717,435...30,725,538

G

Tu translation elongation factor, mitochondrial

multiple interactions

Gold analog results in decreased expression of and results in increased phosphorylation of TUFM protein

NCBI chr16:28,842,411...28,846,348
Ensembl chr16:28,842,411...28,846,348

G

thioredoxin domain containing 5

multiple interactions

Gold analog results in decreased expression of and results in increased phosphorylation of TXNDC5 protein

NCBI chr 6:7,881,517...7,910,788
Ensembl chr 6:7,881,517...7,910,788

G

thioredoxin interacting protein

decreases expression

Gold analog results in decreased expression of TXNIP mRNA

NCBI chr 1:145,992,435...145,996,579
Ensembl chr 1:145,992,435...145,996,579

G

thioredoxin reductase 1

decreases activity
increases expression

Gold results in decreased activity of TXNRD1 protein
Gold results in increased expression of TXNRD1 mRNA

PMID:16510263 PMID:20851179 PMID:29705079

NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307

G

thioredoxin reductase 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of TXNRD2 mRNA

NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820

G

UDP-N-acetylglucosamine pyrophosphorylase 1 like 1

decreases expression

Gold analog results in decreased expression of UAP1L1 protein

NCBI chr 9:137,077,517...137,084,538
Ensembl chr 9:137,077,517...137,084,539

G

ubiquitin like modifier activating enzyme 2

decreases expression

Gold results in decreased expression of UBA2 mRNA

NCBI chr19:34,428,381...34,471,251
Ensembl chr19:34,428,352...34,471,251

G

ubiquitin conjugating enzyme E2 G2

decreases expression

Gold analog results in decreased expression of UBE2G2 mRNA

NCBI chr21:44,768,580...44,801,820
Ensembl chr21:44,768,580...44,801,826

G

ubiquitin conjugating enzyme E2 H

increases expression

Gold results in increased expression of UBE2H mRNA

NCBI chr 7:129,830,732...129,952,960
Ensembl chr 7:129,830,732...129,952,960

G

ubiquitin conjugating enzyme E2 N

decreases expression

Gold results in decreased expression of UBE2N mRNA

NCBI chr12:93,405,684...93,441,947
Ensembl chr12:93,405,673...93,441,947

G

ubiquitin conjugating enzyme E2 W

decreases expression

Gold results in decreased expression of UBE2W mRNA

NCBI chr 8:73,780,096...73,878,862
Ensembl chr 8:73,780,097...73,878,910

G

uncoupling protein 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of UCP2 mRNA

NCBI chr11:73,974,672...73,983,202
Ensembl chr11:73,974,061...73,982,843

G

UDP glucuronosyltransferase family 1 member A1

decreases expression

Gold analog results in decreased expression of UGT1A1 mRNA

NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300

G

UDP glucuronosyltransferase family 2 member A1 complex locus

decreases expression

Gold analog results in decreased expression of UGT2A1 mRNA

NCBI chr 4:69,588,417...69,653,247
Ensembl chr 4:69,588,417...69,653,249

G

ubiquitin interaction motif containing 1

decreases expression
increases expression

Gold results in decreased expression of UIMC1 mRNA
Gold results in increased expression of UIMC1 mRNA

NCBI chr 5:176,905,005...177,022,602
Ensembl chr 5:176,905,005...177,022,633

G

uridine phosphorylase 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of UPP2 mRNA

NCBI chr 2:157,995,179...158,136,154
Ensembl chr 2:157,876,679...158,136,154

G

ubiquitin specific peptidase 1

decreases expression

Gold results in decreased expression of USP1 mRNA

NCBI chr 1:62,436,395...62,451,804
Ensembl chr 1:62,436,297...62,451,804

G

ubiquitin specific peptidase 15

decreases expression

Gold results in decreased expression of USP15 mRNA

NCBI chr12:62,260,404...62,416,389
Ensembl chr12:62,260,338...62,417,431

G

ubiquitin specific peptidase 16

decreases expression

Gold results in decreased expression of USP16 mRNA

NCBI chr21:29,024,668...29,054,488
Ensembl chr21:29,024,629...29,054,488

G

ubiquitin specific peptidase 33

decreases expression

Gold results in decreased expression of USP33 mRNA

NCBI chr 1:77,695,987...77,759,852
Ensembl chr 1:77,695,987...77,759,852

G

ubiquitin specific peptidase 5

decreases expression

Gold analog results in decreased expression of USP5 protein

NCBI chr12:6,852,150...6,866,632
Ensembl chr12:6,852,148...6,866,632

G

vinculin

decreases expression

Gold analog results in decreased expression of VCL protein

NCBI chr10:73,998,116...74,121,363
Ensembl chr10:73,995,193...74,121,363

G

vimentin

increases degradation

Gold analog results in increased degradation of VIM protein

NCBI chr10:17,228,241...17,237,593
Ensembl chr10:17,228,241...17,237,593

G

WW domain binding protein 4

decreases expression

Gold results in decreased expression of WBP4 mRNA

NCBI chr13:41,061,509...41,084,006
Ensembl chr13:41,061,509...41,084,006

G

WEE1 G2 checkpoint kinase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of WEE1 mRNA

NCBI chr11:9,573,670...9,589,985
Ensembl chr11:9,573,670...9,593,457

G

XPA, DNA damage recognition and repair factor

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of XPA mRNA

NCBI chr 9:97,654,398...97,697,340
Ensembl chr 9:97,674,909...97,697,340

G

XPC complex subunit, DNA damage recognition and repair factor

decreases expression

Gold analog results in decreased expression of XPC mRNA

NCBI chr 3:14,145,147...14,178,601
Ensembl chr 3:14,145,145...14,178,621

G

X-ray repair cross complementing 5

decreases expression

Gold analog results in decreased expression of XRCC5 mRNA

NCBI chr 2:216,109,348...216,206,293
Ensembl chr 2:216,107,464...216,206,303

G

YOD1 deubiquitinase

decreases expression

Gold results in decreased expression of YOD1 mRNA

NCBI chr 1:207,043,849...207,053,116
Ensembl chr 1:207,043,849...207,052,980

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of YWHAG mRNA

NCBI chr 7:76,326,799...76,358,991
Ensembl chr 7:76,326,799...76,358,991

G

zinc finger and BTB domain containing 21

decreases expression

Gold results in decreased expression of ZBTB21 mRNA

NCBI chr21:41,986,831...42,010,360
Ensembl chr21:41,986,831...42,010,387

G

zinc finger and BTB domain containing 41

decreases expression

Gold results in decreased expression of ZBTB41 mRNA

NCBI chr 1:197,153,682...197,201,293
Ensembl chr 1:197,153,682...197,201,293

G

zinc finger CCCH-type containing 15

decreases expression

Gold results in decreased expression of ZC3H15 mRNA

NCBI chr 2:186,486,260...186,509,361
Ensembl chr 2:186,486,253...186,511,929

G

zinc finger CCHC-type containing 10

decreases expression

Gold results in decreased expression of ZCCHC10 mRNA

NCBI chr 5:132,996,985...133,026,549
Ensembl chr 5:132,996,985...133,026,604

G

zinc finger CCHC-type containing 9

decreases expression

Gold results in decreased expression of ZCCHC9 mRNA

NCBI chr 5:81,301,587...81,313,297
Ensembl chr 5:81,301,587...81,313,297

G

zinc finger CCHC-type and RNA binding motif containing 1

decreases expression

Gold results in decreased expression of ZCRB1 mRNA

NCBI chr12:42,312,086...42,326,094
Ensembl chr12:42,312,086...42,326,257

G

zinc finger DHHC-type palmitoyltransferase 17

decreases expression

Gold results in decreased expression of ZDHHC17 mRNA

NCBI chr12:76,764,115...76,853,701
Ensembl chr12:76,764,103...76,853,696

G

zinc finger DHHC-type palmitoyltransferase 20

decreases expression

Gold results in decreased expression of ZDHHC20 mRNA

NCBI chr13:21,372,571...21,459,303
Ensembl chr13:21,348,784...21,459,370

G

zinc finger AN1-type containing 1

decreases expression

Gold results in decreased expression of ZFAND1 mRNA

NCBI chr 8:81,701,331...81,721,304
Ensembl chr 8:81,701,334...81,732,903

G

zinc finger AN1-type containing 6

decreases expression

Gold results in decreased expression of ZFAND6 mRNA

NCBI chr15:80,058,951...80,138,393
Ensembl chr15:80,059,568...80,140,292

G

zinc finger FYVE-type containing 16

decreases expression

Gold results in decreased expression of ZFYVE16 mRNA

NCBI chr 5:80,407,610...80,483,379
Ensembl chr 5:80,408,013...80,483,379

G

zinc metallopeptidase STE24

decreases expression

Gold results in decreased expression of ZMPSTE24 mRNA

NCBI chr 1:40,258,236...40,294,180
Ensembl chr 1:40,258,041...40,294,180

G

zinc finger protein 124

decreases expression

Gold results in decreased expression of ZNF124 mRNA

NCBI chr 1:247,121,975...247,172,379
Ensembl chr 1:247,121,975...247,172,020

G

zinc finger protein 22

decreases expression

Gold results in decreased expression of ZNF22 mRNA

NCBI chr10:45,000,923...45,005,326
Ensembl chr10:45,000,923...45,005,326

G

zinc finger protein 273

decreases expression

Gold results in decreased expression of ZNF273 mRNA

NCBI chr 7:64,877,603...64,937,316
Ensembl chr 7:64,870,172...64,930,981

G

zinc finger protein 277

decreases expression

Gold results in decreased expression of ZNF277 mRNA

NCBI chr 7:112,206,695...112,343,934
Ensembl chr 7:112,206,695...112,343,934

G

zinc finger protein 322 pseudogene 1

decreases expression

Gold results in decreased expression of ZNF322P1 mRNA

NCBI chr 9:97,195,351...97,200,145
Ensembl chr 9:97,198,303...97,199,511

G

zinc finger protein 492

decreases expression

Gold results in decreased expression of ZNF492 mRNA

NCBI chr19:22,634,324...22,667,671
Ensembl chr19:22,634,324...22,667,671

G

zinc finger protein 572

decreases expression

Gold results in decreased expression of ZNF572 mRNA

NCBI chr 8:124,973,295...124,979,389
Ensembl chr 8:124,973,295...124,979,389

G

zinc finger protein 721

decreases expression

Gold results in decreased expression of ZNF721 mRNA

NCBI chr 4:439,988...499,156
Ensembl chr 4:425,815...499,156

G

zinc finger protein 92

decreases expression

Gold results in decreased expression of ZNF92 mRNA

NCBI chr 7:65,373,855...65,401,136
Ensembl chr 7:65,373,799...65,401,136

G

zinc finger RANBP2-type containing 2

decreases expression

Gold results in decreased expression of ZRANB2 mRNA

NCBI chr 1:71,063,291...71,081,035
Ensembl chr 1:71,063,291...71,081,289

G

zinc finger containing ubiquitin peptidase 1

decreases expression

Gold results in decreased expression of ZUP1 mRNA

NCBI chr 6:116,635,618...116,668,766
Ensembl chr 6:116,635,618...116,668,794

auranofin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of AKT1 protein]

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

albumin

affects binding

Auranofin analog binds to ALB protein

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

BCL2 antagonist/killer 1

multiple interactions
increases response to substance

[BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAK1 results in increased susceptibility to Auranofin

PMID:18789312 PMID:21172426

NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases response to substance

[BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAX results in increased susceptibility to Auranofin

PMID:18789312 PMID:21172426

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCL2 apoptosis regulator

multiple interactions

BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein]

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

caspase 3

multiple interactions
increases activity

Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]; Auranofin results in decreased expression of and results in increased cleavage of CASP3 protein; BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]

PMID:15159275 PMID:15191400 PMID:18789312 PMID:20542334 PMID:21699084

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 8

multiple interactions

Auranofin results in decreased expression of and results in increased cleavage of CASP8 protein

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

multiple interactions

Auranofin results in decreased expression of and results in increased cleavage of CASP9 protein

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

cyclin dependent kinase inhibitor 1A

increases expression

Auranofin results in increased expression of CDKN1A protein

NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397

G

CCAAT enhancer binding protein epsilon

multiple interactions

[Auranofin co-treated with Tretinoin] results in increased expression of CEBPE protein

NCBI chr14:23,117,306...23,119,255
Ensembl chr14:23,117,036...23,120,256

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Auranofin inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CHUK protein]; Auranofin inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]
Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]

NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596

G

iodothyronine deiodinase 1

decreases activity

Auranofin results in decreased activity of DIO1 protein

NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086

G

epidermal growth factor

multiple interactions

Auranofin promotes the reaction [arsenite results in increased expression of and results in increased secretion of EGF protein]

NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766

G

glutathione peroxidase 1

multiple interactions
increases expression

[Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Auranofin results in increased expression of GPX1 protein]; Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein]

NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605

G

glutathione-disulfide reductase

multiple interactions

Auranofin promotes the reaction [arsenite results in increased activity of GSR protein]

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

major histocompatibility complex, class II, DQ alpha 1

increases response to substance

HLA-DQA1 gene polymorphism results in increased susceptibility to Auranofin

NCBI chr 6:32,637,406...32,655,272
Ensembl chr 6:32,628,179...32,647,062

G

major histocompatibility complex, class II, DR beta 1

increases response to substance

HLA-DRB1 gene polymorphism results in increased susceptibility to Auranofin

NCBI chr 6:32,578,775...32,589,848
Ensembl chr 6:32,577,902...32,589,848

G

heme oxygenase 1

increases expression

Auranofin results in increased expression of HMOX1 mRNA
Auranofin results in increased expression of HMOX1 mRNA; Auranofin results in increased expression of HMOX1 protein

PMID:22008538 PMID:23942037

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

interleukin 1 beta

multiple interactions

Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

multiple interactions

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

interleukin 6 cytokine family signal transducer

multiple interactions

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein

NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022

G

interleukin 1 receptor associated kinase 1

multiple interactions

Auranofin inhibits the reaction [lipopolysaccharide A results in increased degradation of IRAK1 protein]

NCBI chr X:154,010,507...154,019,902
Ensembl chr X:154,010,506...154,019,902

G

interferon regulatory factor 3

multiple interactions

Auranofin inhibits the reaction [lipopolysaccharide A results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [lipopolysaccharide A results in increased phosphorylation of IRF3 protein]; Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein]

NCBI chr19:49,659,572...49,665,857
Ensembl chr19:49,659,569...49,665,875

G

integrin subunit alpha M

multiple interactions

[Auranofin co-treated with Tretinoin] results in increased expression of ITGAM protein

NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892

G

Janus kinase 2

multiple interactions

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein

NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948

G

mitogen-activated protein kinase 1

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK1 protein]

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 3

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK3 protein]

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 8

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK8 protein]

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
decreases expression

[Auranofin co-treated with SN50 peptide] results in decreased expression of MCL1 protein
Auranofin results in decreased expression of MCL1 protein

NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738

G

NFE2 like bZIP transcription factor 2

multiple interactions

Auranofin promotes the reaction [arsenite results in increased expression of NFE2L2 protein]

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

NFKB inhibitor alpha

multiple interactions

Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]

NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749

G

NFKB inhibitor beta

multiple interactions

Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]

NCBI chr19:38,899,666...38,908,889
Ensembl chr19:38,899,700...38,908,893

G

poly(ADP-ribose) polymerase 1

decreases activity
increases cleavage

Auranofin results in decreased activity of PARP1 protein
Auranofin results in increased cleavage of PARP1 protein

PMID:15159275 PMID:21370912

NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154

G

peptidylprolyl isomerase F

increases oxidation
multiple interactions

Auranofin results in increased oxidation of PPIF protein
Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PPIF protein]

NCBI chr10:79,347,469...79,355,334
Ensembl chr10:79,347,469...79,355,334

G

peroxiredoxin 3

increases oxidation
multiple interactions

Auranofin results in increased oxidation of PRDX3 protein
Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PRDX3 protein]
Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of PRDX3 protein]

PMID:18789312 PMID:21355852 PMID:26975474

NCBI chr10:119,167,720...119,178,812
Ensembl chr10:119,167,720...119,178,812

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[lipopolysaccharide A co-treated with Auranofin] results in decreased expression of PTGS2 protein
Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]

PMID:10594346 PMID:17034761

NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922

G

RB transcriptional corepressor 1

decreases phosphorylation

Auranofin results in decreased phosphorylation of RB1 protein

NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436

G

RNA binding motif single stranded interacting protein 3

affects response to substance

RBMS3 protein affects the susceptibility to Auranofin

NCBI chr 3:29,281,071...30,010,395
Ensembl chr 3:28,574,791...30,010,391

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein]; Auranofin promotes the reaction [arsenite results in increased phosphorylation of RELA protein]

PMID:10594346 PMID:36343453

NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090

G

solute carrier family 22 member 2

multiple interactions

Auranofin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638

G

signal transducer and activator of transcription 3

decreases expression
multiple interactions

Auranofin results in decreased expression of STAT3 protein modified form
[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein

NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568

G

TANK binding kinase 1

multiple interactions

Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]

NCBI chr12:64,452,120...64,502,114
Ensembl chr12:64,452,090...64,502,114

G

transforming growth factor alpha

multiple interactions

Auranofin promotes the reaction [arsenite results in increased expression of and results in increased secretion of TGFA protein]

NCBI chr 2:70,447,284...70,553,826
Ensembl chr 2:70,447,284...70,554,193

G

TIR domain containing adaptor molecule 1

multiple interactions

Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein]

NCBI chr19:4,815,932...4,831,712
Ensembl chr19:4,815,932...4,831,712

G

toll like receptor 4

multiple interactions

Auranofin inhibits the reaction [lipopolysaccharide A promotes the reaction [TLR4 protein binds to TLR4 protein]]

NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735

G

tumor necrosis factor

multiple interactions

Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]
Auranofin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

PMID:10820281 PMID:18789312

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

G

thioredoxin

increases oxidation
multiple interactions

Auranofin results in increased oxidation of TXN protein
Auranofin inhibits the reaction [arsenite results in increased expression of TXN protein]

PMID:26975474 PMID:36343453

NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507

G

thioredoxin 2

increases oxidation
multiple interactions

Auranofin results in increased oxidation of TXN2 protein
Cyclosporine promotes the reaction [Auranofin results in increased oxidation of TXN2 protein]

NCBI chr22:36,467,046...36,481,640
Ensembl chr22:36,467,046...36,481,640

G

thioredoxin reductase 1

multiple interactions
decreases activity
increases oxidation
increases expression

Auranofin inhibits the reaction [arsenite results in increased expression of and results in increased activity of TXNRD1 protein]; Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]; Auranofin promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]; potassium tellurate(IV) promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]; Sodium Selenite promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]
Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]
Auranofin results in decreased activity of TXNRD1 protein
Auranofin results in increased expression of TXNRD1 mRNA

PMID:16510263 PMID:18405881 PMID:18789312 PMID:19486940 PMID:20457604 More...

NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307

G

thioredoxin reductase 2

multiple interactions
decreases activity

Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD2 protein]; Auranofin promotes the reaction [Sodium Selenite results in decreased expression of TXNRD2 mRNA]
Auranofin results in decreased activity of TXNRD2 protein

PMID:15458826 PMID:19486940 PMID:21172426 PMID:21355852

NCBI chr22:19,875,522...19,941,818
Ensembl chr22:19,875,517...19,941,820

gold nanoparticle

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tumor necrosis factor

decreases secretion

Topical GNP decreases secretion of Tnf protein in aqeous humor

RGD

NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336

gold(0)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminoadipate-semialdehyde synthase

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of AASS mRNA
Gold analog results in decreased expression of AASS mRNA

PMID:28433809 PMID:36057382

NCBI chr 7:122,073,549...122,144,249
Ensembl chr 7:122,064,583...122,144,308

G

ATP binding cassette subfamily B member 1

increases expression

Gold analog results in increased expression of ABCB1 mRNA

NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323

G

ATP binding cassette subfamily B member 4

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCB4 mRNA
Gold analog results in decreased expression of ABCB4 mRNA

PMID:28433809 PMID:36057382

NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435

G

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCC1 mRNA

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

G

ATP binding cassette subfamily C member 2

increases expression

Gold analog results in increased expression of ABCC2 mRNA

NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ABL1 mRNA

NCBI chr 9:130,713,043...130,887,675
Ensembl chr 9:130,713,043...130,887,675

G

acetyl-CoA acyltransferase 1

decreases expression

Gold analog results in decreased expression of ACAA1 mRNA

NCBI chr 3:38,122,715...38,137,127
Ensembl chr 3:38,103,129...38,137,242

G

acetyl-CoA carboxylase alpha

decreases expression

Gold analog results in decreased expression of ACACA mRNA

NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836

G

acyl-CoA dehydrogenase family member 11

decreases expression

Gold analog results in decreased expression of ACAD11 mRNA

NCBI chr 3:132,558,141...132,659,809
Ensembl chr 3:132,558,138...132,660,082

G

acyl-CoA dehydrogenase medium chain

decreases expression

Gold analog results in decreased expression of ACADM mRNA

NCBI chr 1:75,724,709...75,763,679
Ensembl chr 1:75,724,431...75,787,575

G

acyl-CoA dehydrogenase short chain

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADS mRNA

NCBI chr12:120,725,826...120,740,008
Ensembl chr12:120,725,774...120,740,008

G

acyl-CoA dehydrogenase very long chain

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADVL mRNA

NCBI chr17:7,217,125...7,225,266
Ensembl chr17:7,217,125...7,225,266

G

aconitase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of ACO1 mRNA

NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769

G

aconitase 2

decreases expression
multiple interactions

Gold analog results in decreased expression of ACO2 protein
[Polyethyleneimine binds to Gold] which results in increased expression of ACO2 mRNA

PMID:24780912 PMID:28433809

NCBI chr22:41,469,117...41,528,974
Ensembl chr22:41,447,830...41,529,273

G

acyl-CoA oxidase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ACOX1 mRNA

NCBI chr17:75,941,507...75,979,166
Ensembl chr17:75,941,507...75,979,177

G

acyl-CoA oxidase 2

decreases expression

Gold analog results in decreased expression of ACOX2 mRNA

NCBI chr 3:58,505,136...58,537,190
Ensembl chr 3:58,505,136...58,537,283

G

acid phosphatase 1

decreases expression

Gold results in decreased expression of ACP1 mRNA

NCBI chr 2:264,947...278,283
Ensembl chr 2:264,140...278,283

G

activin A receptor type 1C

decreases expression

Gold results in decreased expression of ACVR1C mRNA

NCBI chr 2:157,526,767...157,628,864
Ensembl chr 2:157,526,767...157,628,864

G

ADAM metallopeptidase domain 28

increases expression

Gold results in increased expression of ADAM28 mRNA

NCBI chr 8:24,294,069...24,359,014
Ensembl chr 8:24,294,069...24,359,014

G

alcohol dehydrogenase 5 (class III), chi polypeptide

decreases expression

Gold results in decreased expression of ADH5 mRNA

NCBI chr 4:99,070,978...99,088,788
Ensembl chr 4:99,070,978...99,088,801

G

adiponectin receptor 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ADIPOR2 mRNA

NCBI chr12:1,691,070...1,788,674
Ensembl chr12:1,688,574...1,788,674

G

adrenoceptor alpha 1B

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRA1B mRNA

NCBI chr 5:159,865,086...159,989,205
Ensembl chr 5:159,865,080...159,973,012

G

adrenoceptor beta 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRB2 mRNA

NCBI chr 5:148,826,611...148,828,623
Ensembl chr 5:148,826,611...148,828,623

G

alpha 2-HS glycoprotein

decreases expression

Gold analog results in decreased expression of AHSG mRNA

NCBI chr 3:186,613,060...186,621,318
Ensembl chr 3:186,613,060...186,621,318

G

apoptosis inducing factor mitochondria associated 1

increases expression

Gold results in increased expression of AIFM1 protein

NCBI chr X:130,129,362...130,165,841
Ensembl chr X:130,124,666...130,165,879

G

aminoacyl tRNA synthetase complex interacting multifunctional protein 1

decreases expression

Gold results in decreased expression of AIMP1 mRNA

NCBI chr 4:106,315,544...106,349,456
Ensembl chr 4:106,315,544...106,349,456

G

adenylate kinase 3

decreases expression

Gold results in decreased expression of AK3 mRNA

NCBI chr 9:4,709,556...4,742,043
Ensembl chr 9:4,709,556...4,742,043

G

A-kinase anchoring protein 13

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of AKAP13 mRNA

NCBI chr15:85,380,603...85,749,358
Ensembl chr15:85,380,571...85,749,358

G

aldo-keto reductase family 1 member B10

increases expression

Gold results in increased expression of AKR1B10 mRNA

NCBI chr 7:134,527,567...134,541,412
Ensembl chr 7:134,527,567...134,541,412

G

aldo-keto reductase family 1 member C2

increases expression

Gold results in increased expression of AKR1C2 mRNA

NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031

G

aldo-keto reductase family 1 member C3

increases expression

Gold results in increased expression of AKR1C3 mRNA

NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686

G

AKT serine/threonine kinase 1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of AKT1 protein

NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759

G

albumin

multiple interactions
increases expression

ALB protein results in increased uptake of [Polyethylene Glycols binds to Gold]; ALB protein results in increased uptake of [Polyethyleneimine binds to Gold]; ALB protein results in increased uptake of [Thioctic Acid binds to Gold]
Gold analog results in increased expression of ALB mRNA

PMID:28433809 PMID:36057382

NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482

G

annexin A5

increases expression

Gold analog results in increased expression of ANXA5 protein

NCBI chr 4:121,667,946...121,696,980
Ensembl chr 4:121,667,946...121,696,995

G

apoptotic peptidase activating factor 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of APAF1 mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein
Gold analog results in decreased expression of APAF1 mRNA

PMID:27470402 PMID:28433809 PMID:36057382

NCBI chr12:98,645,290...98,735,433
Ensembl chr12:98,645,149...98,735,433

G

apurinic/apyrimidinic endodeoxyribonuclease 1

decreases expression

Gold analog results in decreased expression of APEX1 mRNA

NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772

G

apolipoprotein A4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of APOA4 mRNA

NCBI chr11:116,820,700...116,823,304
Ensembl chr11:116,820,700...116,823,304

G

adenine phosphoribosyltransferase

decreases expression

Gold analog results in decreased expression of APRT protein

NCBI chr16:88,809,339...88,811,928
Ensembl chr16:88,809,339...88,811,937

G

aquaporin 4

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of AQP4 mRNA

NCBI chr18:26,852,038...26,865,803
Ensembl chr18:26,852,043...26,865,771

G

ARF like GTPase 1

decreases expression

Gold results in decreased expression of ARL1 mRNA

NCBI chr12:101,393,116...101,407,820
Ensembl chr12:101,393,116...101,407,772

G

ARF like GTPase 5B

decreases expression

Gold results in decreased expression of ARL5B mRNA

NCBI chr10:18,659,431...18,681,639
Ensembl chr10:18,659,431...18,681,639

G

arylsulfatase G

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ARSG mRNA

NCBI chr17:68,259,170...68,452,019
Ensembl chr17:68,259,182...68,422,731

G

N-acylsphingosine amidohydrolase 1

decreases expression

Gold analog results in decreased expression of ASAH1 mRNA

NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998

G

activating transcription factor 1

decreases expression

Gold results in decreased expression of ATF1 mRNA

NCBI chr12:50,763,459...50,821,162
Ensembl chr12:50,763,710...50,821,162

G

activating transcription factor 4

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of ATF4 mRNA

NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,686

G

activating transcription factor 6

increases cleavage

Gold analog results in increased cleavage of ATF6 protein

NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

decreases expression

Gold analog results in decreased expression of ATIC protein

NCBI chr 2:215,312,059...215,368,592
Ensembl chr 2:215,311,956...215,349,773

G

atlastin GTPase 2

decreases expression

Gold results in decreased expression of ATL2 mRNA

NCBI chr 2:38,293,954...38,378,584
Ensembl chr 2:38,293,954...38,377,285

G

ATM serine/threonine kinase

decreases expression

Gold analog results in decreased expression of ATM mRNA

NCBI chr11:108,223,067...108,369,102
Ensembl chr11:108,222,804...108,369,102

G

ATPase plasma membrane Ca2+ transporting 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ATP2B1 mRNA

NCBI chr12:89,588,049...89,709,366
Ensembl chr12:89,588,049...89,709,366

G

ATP synthase F1 subunit beta

multiple interactions

Gold analog results in increased expression of and results in decreased phosphorylation of ATP5F1B protein

NCBI chr12:56,638,175...56,645,984
Ensembl chr12:56,638,175...56,645,984

G

ATPase H+ transporting V1 subunit G2

decreases expression

Gold analog results in decreased expression of ATP6V1G2 mRNA

NCBI chr 6:31,544,444...31,546,742
Ensembl chr 6:31,544,444...31,548,427

G

ATR serine/threonine kinase

decreases expression

Gold analog results in decreased expression of ATR mRNA

NCBI chr 3:142,449,235...142,578,733
Ensembl chr 3:142,449,007...142,578,733

G

beta-secretase 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BACE1 mRNA

NCBI chr11:117,285,698...117,316,256
Ensembl chr11:117,285,232...117,316,259

G

BCL2 associated agonist of cell death

multiple interactions

[Quercetin analog co-treated with Gold analog] results in increased expression of BAD protein

NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704

G

BAR/IMD domain containing adaptor protein 2

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of BAIAP2 mRNA

NCBI chr17:81,035,151...81,117,434
Ensembl chr17:81,035,122...81,117,434

G

BCL2 antagonist/killer 1

increases expression

Gold results in increased expression of BAK1 mRNA

NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein; [Gold analog co-treated with Platinum] results in increased expression of BAX mRNA; [Polyethyleneimine binds to Gold] which results in decreased expression of BAX mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of BAX protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of BAX protein
Gold results in increased expression of BAX mRNA

PMID:21621595 PMID:22178767 PMID:25846798 PMID:27470402 PMID:27836789 More...

NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798

G

BCAS2 pre-mRNA processing factor

decreases expression

Gold results in decreased expression of BCAS2 mRNA

NCBI chr 1:114,567,557...114,581,615
Ensembl chr 1:114,567,557...114,581,629

G

BCL2 apoptosis regulator

multiple interactions

[Gold analog co-treated with Platinum] results in decreased expression of BCL2 mRNA; [Quercetin analog co-treated with Gold analog] results in decreased expression of BCL2 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in decreased expression of BCL2 protein

PMID:25846798 PMID:27470402 PMID:27836789

NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128

G

BCL2 like 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of BCL2L1 mRNA

NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989

G

BCL2 like 11

decreases expression

Gold analog results in decreased expression of BCL2L11 mRNA

NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,444

G

baculoviral IAP repeat containing 2

decreases expression

Gold results in decreased expression of BIRC2 mRNA

NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670

G

baculoviral IAP repeat containing 3

decreases expression

Gold analog results in decreased expression of BIRC3 mRNA; Gold results in decreased expression of BIRC3 mRNA

PMID:25523186 PMID:36057382

NCBI chr11:102,317,484...102,339,403
Ensembl chr11:102,317,484...102,339,403

G

basic helix-loop-helix ARNT like 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BMAL1 mRNA

NCBI chr11:13,276,652...13,387,266
Ensembl chr11:13,276,652...13,387,266

G

BMI1 proto-oncogene, polycomb ring finger

decreases expression

Gold results in decreased expression of BMI1 mRNA

NCBI chr10:22,321,099...22,331,706
Ensembl chr10:22,321,099...22,331,484

G

BRCA1 DNA repair associated

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA1 mRNA
Gold analog results in decreased expression of BRCA1 mRNA

PMID:28433809 PMID:36057382

NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245

G

BRCA2 DNA repair associated

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA2 mRNA
Gold analog results in decreased expression of BRCA2 mRNA

PMID:28433809 PMID:36057382

NCBI chr13:32,315,077...32,400,268
Ensembl chr13:32,315,086...32,400,268

G

chromosome 11 open reading frame 54

decreases expression

Gold results in decreased expression of C11ORF54 mRNA

NCBI chr11:93,741,672...93,764,749
Ensembl chr11:93,741,591...93,764,749

G

C1D nuclear receptor corepressor

decreases expression

Gold results in decreased expression of C1D mRNA

NCBI chr 2:68,041,130...68,063,004
Ensembl chr 2:68,041,130...68,110,948

G

complement C3

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of C3 mRNA

NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562

G

complement C9

decreases expression

Gold analog results in decreased expression of C9 mRNA

NCBI chr 5:39,284,140...39,364,495
Ensembl chr 5:39,284,140...39,371,324

G

carbonic anhydrase 13

decreases expression

Gold results in decreased expression of CA13 mRNA

NCBI chr 8:85,245,458...85,284,073
Ensembl chr 8:85,220,587...85,284,073

G

capping actin protein of muscle Z-line subunit alpha 2

decreases expression

Gold results in decreased expression of CAPZA2 mRNA

NCBI chr 7:116,862,587...116,922,049
Ensembl chr 7:116,811,070...116,922,049

G

caspase 1

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of CASP1 mRNA

NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250

G

caspase 3

multiple interactions
increases activity
increases cleavage
increases expression

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP3 mRNA; [Polyethyleneimine binds to Gold] which results in increased expression of CASP3 mRNA; [Quercetin analog co-treated with Gold analog] results in increased cleavage of CASP3 protein; [Quercetin analog co-treated with Gold analog] results in increased expression of and results in increased activity of CASP3 protein; Dexamethasone promotes the reaction [Gold results in increased activity of CASP3 protein]; Etoposide promotes the reaction [Gold results in increased activity of CASP3 protein]
Gold analog results in increased cleavage of CASP3 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP3 protein
Gold results in increased expression of CASP3 mRNA

PMID:19760634 PMID:21621595 PMID:22178767 PMID:25846798 PMID:26551149 More...

NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062

G

caspase 4

increases cleavage

Gold analog results in increased cleavage of CASP4 protein

NCBI chr11:104,942,866...104,968,574
Ensembl chr11:104,942,866...104,969,366

G

caspase 7

increases cleavage

Gold analog results in increased cleavage of CASP7 protein

NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907

G

caspase 8

increases expression
decreases expression

Gold results in increased expression of CASP8 mRNA
Gold analog results in decreased expression of CASP8 mRNA

PMID:22178767 PMID:36057382

NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836

G

caspase 9

multiple interactions
increases cleavage

[Gold analog co-treated with Platinum] results in increased activity of CASP9 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP9 mRNA
Gold analog results in increased cleavage of CASP9 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP9 protein

PMID:25846798 PMID:26551149 PMID:27836789

NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534

G

catalase

multiple interactions

[Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

chromobox 3

decreases expression

Gold results in decreased expression of CBX3 mRNA

NCBI chr 7:26,201,443...26,213,607
Ensembl chr 7:26,201,162...26,213,607

G

C-C motif chemokine ligand 2

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL2 protein
Gold results in increased secretion of CCL2 protein

NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208

G

C-C motif chemokine ligand 5

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL5 protein
Gold results in increased secretion of CCL5 protein

NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793

G

C-C motif chemokine ligand 7

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL7 protein
Gold results in increased secretion of CCL7 protein

NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242

G

cyclin D1

multiple interactions

[Quercetin analog co-treated with Gold analog] results in decreased expression of CCND1 protein

NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474

G

chaperonin containing TCP1 subunit 5

decreases expression

Gold analog results in decreased expression of CCT5 protein

NCBI chr 5:10,249,921...10,266,412
Ensembl chr 5:10,249,929...10,266,389

G

CD19 molecule

increases expression

Gold analog results in increased expression of CD19 mRNA

NCBI chr16:28,931,971...28,939,342
Ensembl chr16:28,931,965...28,939,342

G

CD36 molecule (CD36 blood group)

decreases expression

Gold analog results in decreased expression of CD36 mRNA

NCBI chr 7:80,602,207...80,679,274
Ensembl chr 7:80,369,575...80,679,277

G

CD40 molecule

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CD40 mRNA

NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863

G

CD86 molecule

decreases expression

Gold analog results in decreased expression of CD86 mRNA

NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139

G

cytidine deaminase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CDA mRNA

NCBI chr 1:20,589,097...20,618,903
Ensembl chr 1:20,589,086...20,618,903

G

cyclin dependent kinase 1

decreases expression
increases expression

Gold results in decreased expression of CDK1 mRNA
Gold results in increased expression of CDK1 mRNA

PMID:25523186 PMID:29705079

NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852

G

cyclin dependent kinase 7

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CDK7 mRNA

NCBI chr 5:69,234,795...69,277,430
Ensembl chr 5:69,234,795...69,277,430

G

cyclin dependent kinase inhibitor 1B

multiple interactions

[Gold binds to Dimethyldithiocarbamate] which results in increased expression of CDKN1B protein

NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369

G

CDKN2A interacting protein

decreases expression

Gold results in decreased expression of CDKN2AIP mRNA

NCBI chr 4:183,444,636...183,449,064
Ensembl chr 4:183,444,635...183,449,064

G

cell growth regulator with ring finger domain 1

decreases expression

Gold results in decreased expression of CGRRF1 mRNA

NCBI chr14:54,509,906...54,539,292
Ensembl chr14:54,509,812...54,539,292

G

checkpoint kinase 1

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA
Gold analog results in decreased expression of CHEK1 mRNA

PMID:28433809 PMID:36057382

NCBI chr11:125,625,136...125,681,124
Ensembl chr11:125,625,163...125,676,255

G

checkpoint kinase 2

decreases expression

Gold analog results in decreased expression of CHEK2 mRNA

NCBI chr22:28,687,743...28,741,834
Ensembl chr22:28,687,743...28,742,422

G

cysteine and histidine rich domain containing 1

decreases expression

Gold results in decreased expression of CHORDC1 mRNA

NCBI chr11:90,200,429...90,223,049
Ensembl chr11:90,200,429...90,223,077

G

CDGSH iron sulfur domain 1

decreases expression

Gold results in decreased expression of CISD1 mRNA

NCBI chr10:58,269,162...58,289,586
Ensembl chr10:58,269,162...58,289,586

G

claudin 12

decreases expression

Gold results in decreased expression of CLDN12 mRNA

NCBI chr 7:90,403,461...90,415,954
Ensembl chr 7:90,383,721...90,513,402

G

CCHC-type zinc finger nucleic acid binding protein

decreases expression

Gold results in decreased expression of CNBP mRNA

NCBI chr 3:129,167,827...129,183,896
Ensembl chr 3:129,167,827...129,183,922

G

CCR4-NOT transcription complex subunit 7

decreases expression

Gold results in decreased expression of CNOT7 mRNA

NCBI chr 8:17,224,966...17,246,857
Ensembl chr 8:17,224,966...17,246,878

G

collagen type I alpha 1 chain

increases expression

Gold analog results in increased expression of COL1A1 protein

NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632

G

collagen type I alpha 2 chain

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL1A2 mRNA

NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227

G

collagen type III alpha 1 chain

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL3A1 mRNA

NCBI chr 2:188,974,373...189,012,746
Ensembl chr 2:188,974,373...189,012,746

G

COMM domain containing 8

decreases expression

Gold results in decreased expression of COMMD8 mRNA

NCBI chr 4:47,450,787...47,463,702
Ensembl chr 4:47,450,787...47,463,702

G

cytochrome c oxidase copper chaperone COX11

decreases expression

Gold results in decreased expression of COX11 mRNA

NCBI chr17:54,951,902...54,968,785
Ensembl chr17:54,951,902...54,968,703

G

cytochrome c oxidase copper chaperone COX17

decreases expression

Gold results in decreased expression of COX17 mRNA

NCBI chr 3:119,663,975...119,677,406
Ensembl chr 3:119,654,513...119,677,454

G

carnitine palmitoyltransferase 1A

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT1A mRNA

NCBI chr11:68,754,620...68,844,277
Ensembl chr11:68,754,620...68,844,410

G

carnitine palmitoyltransferase 2

multiple interactions

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT2 mRNA

NCBI chr 1:53,196,824...53,214,197
Ensembl chr 1:53,196,792...53,214,197

G

carnitine O-octanoyltransferase

decreases expression

Gold analog results in decreased expression of CROT mRNA

NCBI chr 7:87,345,664...87,399,794
Ensembl chr 7:87,345,664...87,399,794

G

colony stimulating factor 2

multiple interactions
increases secretion

[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF2 protein
Gold results in increased secretion of CSF2 protein

NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170

G

colony stimulating factor 3

increases secretion
multiple interactions

Gold results in increased secretion of CSF3 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF3 protein

NCBI chr17:40,015,440...40,017,813
Ensembl chr17:40,015,361...40,017,813

G

CCCTC-binding factor

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CTCF mRNA

NCBI chr16:67,562,526...67,639,185
Ensembl chr16:67,562,467...67,639,177

G

cut like homeobox 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CUX1 mRNA

NCBI chr 7:101,816,007...102,283,958
Ensembl chr 7:101,815,904...102,283,958

G

C-X-C motif chemokine ligand 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL1 mRNA

NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308

G

C-X-C motif chemokine ligand 10

increases secretion
multiple interactions

Gold results in increased secretion of CXCL10 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL10 protein

NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497

G

C-X-C motif chemokine ligand 2

multiple interactions
increases secretion

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL2 mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL2 protein
Gold results in increased secretion of CXCL2 protein

PMID:19695318 PMID:22155353

NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196

G

cytochrome c, somatic

multiple interactions

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of CYCS protein

NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260

G

cytochrome P450 family 1 subfamily A member 1

increases activity
decreases expression
multiple interactions

Gold analog results in increased activity of CYP1A1 protein
Gold analog results in decreased expression of CYP1A1 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of CYP1A1 mRNA

PMID:20193702 PMID:28433809 PMID:36057382

NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536

G

cytochrome P450 family 24 subfamily A member 1

increases expression

Gold results in increased expression of CYP24A1 mRNA

NCBI chr20:54,143,538...54,173,986
Ensembl chr20:54,153,446...54,173,986

G

cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)

multiple interactions
decreases expression

[Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA
Gold analog results in decreased expression of CYP2D6 mRNA

PMID:28433809 PMID:36057382

NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865

G

cytochrome P450 family 2 subfamily E member 1

decreases expression

Gold analog results in decreased expression of CYP2E1 mRNA

NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220

G

cytochrome P450 family 7 subfamily A member 1

increases expression

Gold analog results in increased expression of CYP7A1 mRNA

NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163

G

cytohesin 1

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of CYTH1 mRNA

NCBI chr17:78,674,048...78,782,273
Ensembl chr17:78,674,048...78,782,297

G

DAB adaptor protein 2

increases expression

Gold results in increased expression of DAB2 mRNA

NCBI chr 5:39,371,677...39,424,980
Ensembl chr 5:39,371,675...39,462,300

G

decapping mRNA 2

decreases expression

Gold results in decreased expression of DCP2 mRNA

NCBI chr 5:112,976,798...113,022,195
Ensembl chr 5:112,976,702...113,022,195

G

dopa decarboxylase

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DDC mRNA

NCBI chr 7:50,458,442...50,565,405
Ensembl chr 7:50,458,436...50,565,405

G

DNA damage inducible transcript 3

multiple interactions

[Polyethyleneimine binds to Gold] which results in increased expression of DDIT3 mRNA

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

DNA damage inducible transcript 4

multiple interactions

[Gold co-treated with Polyethylene Glycols] results in increased expression of DDIT4 mRNA

NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036