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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:L-mimosine
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Accession:CHEBI:29063 term browser browse the term
Definition:An L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica.
Synonyms:exact_synonym: (2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)propanoic acid
 related_synonym: (S)-2-Amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate;   Formula=C8H10N2O4;   InChI=1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1;   InChIKey=WZNJWVWKTVETCG-YFKPBYRVSA-N;   SMILES=C1=C(C(C=CN1C[C@@H](C(O)=O)N)=O)O
 alt_id: CHEBI:11029;   CHEBI:18732;   CHEBI:375
 xref: CAS:500-44-7;   Drug_Central:1811;   HMDB:HMDB0015188;   KEGG:C04771;   KNApSAcK:C00001383
 xref_mesh: MESH:D008898
 xref: PDBeChem:MMS;   PMID:12797899;   PMID:15938198;   PMID:28661582;   Reaxys:86165;   Wikipedia:Mimosine
 cyclic_relationship: is_conjugate_acid_of CHEBI:58604;   is_tautomer_of CHEBI:77689


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L-mimosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arnt aryl hydrocarbon receptor nuclear translocator increases activity EXP Mimosine results in increased activity of ARNT protein CTD PMID:10559391 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Atf1 activating transcription factor 1 increases activity EXP Mimosine results in increased activity of ATF1 protein CTD PMID:10559391 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670 		JBrowse link
G Bcl2 BCL2, apoptosis regulator affects expression ISO Mimosine affects the expression of BCL2 protein CTD PMID:18058236 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Mimosine results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:18058236 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO Mimosine results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:18058236 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Mimosine results in decreased activity of TNF protein] CTD PMID:15550384 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Mimosine results in decreased expression of CCND1 CTD PMID:10530763 PMID:10995875 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Mimosine results in increased expression of CDKN1A CTD PMID:10530763 PMID:10995875 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Mimosine results in increased expression of CDKN1B CTD PMID:10530763 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases activity EXP Mimosine results in increased activity of CREB1 protein CTD PMID:10559391 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression EXP
ISO		 Mimosine results in increased expression of ECE1 mRNA; Mimosine results in increased expression of ECE1 protein CTD PMID:25469848 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371 		JBrowse link
G Edn1 endothelin 1 increases expression ISO
EXP		 Mimosine results in increased expression of EDN1 mRNA; Mimosine results in increased expression of EDN1 protein CTD PMID:25469848 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity
increases expression		 EXP
ISO		 Mimosine results in increased activity of HIF1A protein
Mimosine results in increased expression of HIF1A protein		 CTD PMID:10559391 PMID:24349381 PMID:25469848 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor decreases expression EXP
ISO		 Mimosine results in decreased expression of LHCGR mRNA CTD PMID:19293332 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521 		JBrowse link
G Nmbr neuromedin B receptor increases expression ISO Mimosine results in increased expression of NMBR protein CTD PMID:24349381 NCBI chr 1:9,115,033...9,146,081
Ensembl chr 1:9,134,889...9,145,462 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO
EXP		 Mimosine results in increased expression of SLC2A1 mRNA CTD PMID:25469848 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation EXP Mimosine results in increased phosphorylation of STAT3 protein CTD PMID:25469848 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases activity		 ISO
EXP		 Acetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; ferrous sulfate inhibits the reaction [Mimosine results in decreased activity of TNF protein]
Acetylcysteine inhibits the reaction [Mimosine results in decreased activity of TNF protein]; CAT protein inhibits the reaction [Mimosine results in decreased activity of TNF protein]		 CTD PMID:15550384 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions
increases cleavage		 ISO Acetylcysteine inhibits the reaction [Mimosine results in increased cleavage of TNFRSF1A protein] CTD PMID:15550384 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      application 19689
        pharmaceutical 19525
          drug 19525
            antifungal drug 5946
              propionic acid 3873
                L-mimosine 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        amino acid 16057
                                          alpha-amino acid 13932
                                            L-alpha-amino acid 12141
                                              non-proteinogenic L-alpha-amino acid 2917
                                                L-mimosine 19
paths to the root