hexane - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	hexane	go back to main search page
Accession:	CHEBI:29021	browse the term
Definition:	An unbranched alkane containing six carbon atoms.
Synonyms:	related_synonym:	CH3-[CH2]4-CH3; Formula=C6H14; Hexan; InChI=1S/C6H14/c1-3-5-6-4-2/h3-6H2,1-2H3; InChIKey=VLKZOEOYAKHREP-UHFFFAOYSA-N; SMILES=CCCCCC; n-Hexane
	alt_id:	CHEBI:10606; CHEBI:24566; CHEBI:24568; CHEBI:43148
	xref:	Beilstein:1730733; CAS:110-54-3; DrugBank:DB02764; Gmelin:1985; HMDB:HMDB0029600; KEGG:C11271; LIPID_MAPS_instance:LMFA11000007
	xref_mesh:	MESH:C026385
	xref:	PDBeChem:HEX; PMID:11292478; PMID:11684179; PMID:11886809; PMID:15325316; PMID:18231777; PMID:19229957; PMID:19384711; PMID:23452516; PMID:23567114; PMID:23620851; PMID:23740543; PMID:23822317; PMID:23931182; PMID:7612176; Reaxys:1730733; Wikipedia:Hexane

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Genes (466)

hexane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor beta 1

multiple interactions

[Particulate Matter co-treated with n-hexane] results in decreased expression of ADRB1 mRNA

NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259

G

adrenoceptor beta 2

multiple interactions

[Particulate Matter co-treated with n-hexane] results in decreased expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

aldo-keto reductase family 1 member B1

increases expression

n-hexane results in increased expression of AKR1B1 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 1 member B10

increases expression

n-hexane results in increased expression of AKR1B10 mRNA

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C1

increases expression

n-hexane results in increased expression of AKR1C1 mRNA

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C3

increases expression

n-hexane results in increased expression of AKR1C3 mRNA

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

alkaline phosphatase, biomineralization associated

decreases methylation

n-hexane results in decreased methylation of ALPL promoter

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

amphiregulin

decreases methylation

n-hexane results in decreased methylation of AREG promoter

NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535

G

Rho GTPase activating protein 45

increases methylation

n-hexane results in increased methylation of ARHGAP45 promoter

NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268

G

atlastin GTPase 2

decreases methylation

n-hexane results in decreased methylation of ATL2 promoter

NCBI chr 6:15,139,071...15,180,421
Ensembl chr 6:15,139,044...15,180,421

G

BCL2 associated X, apoptosis regulator

increases expression

n-hexane metabolite results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

increases expression

n-hexane metabolite results in increased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-associated transcription factor 1

decreases methylation

n-hexane results in decreased methylation of BCLAF1 promoter

NCBI chr 1:15,088,436...15,117,666
Ensembl chr 1:15,070,894...15,148,832

G

similar to human chromosome 19 open reading frame 44

increases methylation

n-hexane results in increased methylation of C16H19ORF44 promoter

NCBI chr16:17,379,999...17,396,088
Ensembl chr16:17,380,003...17,396,002

G

calreticulin 3

increases methylation

n-hexane results in increased methylation of CALR3 promoter

NCBI chr16:17,396,064...17,423,166
Ensembl chr16:17,396,247...17,423,015

G

cyclase associated actin cytoskeleton regulatory protein 1

decreases methylation

n-hexane results in decreased methylation of CAP1 promoter

NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769

G

caspase 3

increases expression

n-hexane metabolite results in increased expression of CASP3 protein

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cyclin K

decreases methylation

n-hexane results in decreased methylation of CCNK promoter

NCBI chr 6:127,090,115...127,113,195
Ensembl chr 6:127,090,569...127,113,191

G

cilia and flagella associated protein 20

decreases methylation

n-hexane results in decreased methylation of CFAP20 promoter

NCBI chr19:9,608,867...9,622,558
Ensembl chr19:9,608,859...9,622,558

G

cysteine-rich hydrophobic domain 2

decreases methylation

n-hexane results in decreased methylation of CHIC2 promoter

NCBI chr14:33,157,669...33,192,015
Ensembl chr14:33,157,537...33,191,895

G

charged multivesicular body protein 2A

decreases methylation

n-hexane results in decreased methylation of CHMP2A promoter

NCBI chr 1:73,660,045...73,662,894
Ensembl chr 1:73,660,046...73,662,452

G

chloride voltage-gated channel 2

decreases methylation

n-hexane results in decreased methylation of CLCN2 promoter

NCBI chr11:80,197,741...80,211,657
Ensembl chr11:80,198,153...80,211,657

G

coordinator of PRMT5 and differentiation stimulator

decreases methylation

n-hexane results in decreased methylation of COPRS promoter

NCBI chr16:75,721,264...75,726,375
Ensembl chr16:75,720,061...75,726,375

G

COPI coat complex subunit zeta 2

decreases methylation

n-hexane results in decreased methylation of COPZ2 promoter

NCBI chr10:81,832,441...81,845,514
Ensembl chr10:81,832,418...81,845,514

G

CDP-L-ribitol pyrophosphorylase A

decreases methylation

n-hexane results in decreased methylation of CRPPA promoter

NCBI chr 6:53,120,264...53,397,030
Ensembl chr 6:53,121,438...53,397,028

G

chondroitin sulfate proteoglycan 4

increases methylation

n-hexane results in increased methylation of CSPG4 promoter

NCBI chr 8:57,264,962...57,300,010
Ensembl chr 8:57,264,962...57,300,010

G

collagen triple helix repeat containing 1

decreases methylation

n-hexane results in decreased methylation of CTHRC1 promoter

NCBI chr 7:70,122,474...70,132,756
Ensembl chr 7:70,122,474...70,132,756

G

cullin 4A

decreases methylation

n-hexane results in decreased methylation of CUL4A promoter

NCBI chr16:76,385,298...76,422,316
Ensembl chr16:76,384,546...76,422,330

G

cytochrome P450, family 11, subfamily a, polypeptide 1

affects expression
affects methylation

n-hexane affects the expression of CYP11A1 mRNA; n-hexane affects the expression of CYP11A1 protein
n-hexane affects the methylation of CYP11A1 promoter

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 17, subfamily a, polypeptide 1

affects expression
affects methylation

n-hexane affects the expression of CYP17A1 mRNA; n-hexane affects the expression of CYP17A1 protein
n-hexane affects the methylation of CYP17A1 promoter

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases hydroxylation
multiple interactions

CYP1A1 protein results in increased hydroxylation of n-hexane
diallyl trisulfide promotes the reaction [n-hexane results in increased expression of and results in increased activity of CYP1A1 protein]; n-hexane results in increased expression of and results in increased activity of CYP1A1 protein

PMID:16484137 PMID:28115069

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases hydroxylation
multiple interactions

CYP1A2 protein results in increased hydroxylation of n-hexane
diallyl trisulfide inhibits the reaction [n-hexane results in increased expression of CYP1A2 protein]; n-hexane results in increased expression of and results in increased activity of CYP1A2 protein

PMID:16484137 PMID:28115069

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions
increases activity

diallyl trisulfide inhibits the reaction [n-hexane results in increased activity of CYP2B1 protein]

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases hydroxylation

CYP2B1 protein results in increased hydroxylation of n-hexane; CYP2B6 protein results in increased hydroxylation of n-hexane

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily e, polypeptide 1

affects response to substance
multiple interactions
increases metabolic processing
increases hydroxylation

CYP2E1 gene polymorphism affects the susceptibility to n-hexane
diallyl trisulfide inhibits the reaction [n-hexane results in increased expression of and results in increased activity of CYP2E1 protein]; n-hexane results in increased expression of and results in increased activity of CYP2E1 protein
CYP2E1 protein results in increased metabolism of n-hexane
CYP2E1 protein results in increased hydroxylation of n-hexane

PMID:11201664 PMID:16484137 PMID:28115069

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

disco-interacting protein 2 homolog C

decreases methylation

n-hexane results in decreased methylation of DIP2C promoter

NCBI chr17:60,647,346...61,032,467
Ensembl chr17:60,649,065...61,032,305

G

DNA methyltransferase 1

decreases methylation

n-hexane results in decreased methylation of DNMT1 promoter

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

DNA methyltransferase 3 alpha

decreases methylation

n-hexane results in decreased methylation of DNMT3A promoter

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

deoxynucleotidyltransferase, terminal, interacting protein 1

decreases methylation

n-hexane results in decreased methylation of DNTTIP1 promoter

NCBI chr 3:153,481,718...153,505,403
Ensembl chr 3:153,481,705...153,505,759

G

dopamine receptor D5

decreases methylation

n-hexane results in decreased methylation of DRD5 promoter

NCBI chr14:72,487,950...72,491,050
Ensembl chr14:72,489,347...72,490,774

G

E2F transcription factor 3

decreases methylation

n-hexane results in decreased methylation of E2F3 promoter

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

epsin 3

decreases methylation

n-hexane results in decreased methylation of EPN3 promoter

NCBI chr10:79,438,978...79,449,516
Ensembl chr10:79,438,978...79,447,356

G

FAM20A, golgi associated secretory pathway pseudokinase

increases methylation

n-hexane results in increased methylation of FAM20A promoter

NCBI chr10:94,638,836...94,697,814
Ensembl chr10:94,642,850...94,697,672

G

ferrochelatase

increases expression

n-hexane results in increased expression of FECH mRNA

NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348

G

fibroblast growth factor binding protein 1

decreases methylation

n-hexane results in decreased methylation of FGFBP1 promoter

NCBI chr14:67,103,686...67,107,492
Ensembl chr14:67,104,545...67,107,496

G

four-jointed box kinase 1

decreases methylation

n-hexane results in decreased methylation of FJX1 promoter

NCBI chr 3:88,774,220...88,776,321
Ensembl chr 3:88,774,220...88,776,321

G

flavin containing dimethylaniline monoxygenase 3

decreases methylation

n-hexane results in decreased methylation of FMO3 promoter

NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028

G

forkhead box I1

decreases methylation

n-hexane results in decreased methylation of FOXI1 promoter

NCBI chr10:18,806,292...18,810,231
Ensembl chr10:18,806,308...18,810,231

G

ferritin light chain 1

increases expression

n-hexane results in increased expression of FTL mRNA

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725

G

glucose-6-phosphate dehydrogenase

increases expression

n-hexane results in increased expression of G6PD mRNA

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

polypeptide N-acetylgalactosaminyltransferase 17

decreases methylation

n-hexane results in decreased methylation of GALNT17 promoter

NCBI chr12:25,323,230...25,781,897
Ensembl chr12:25,322,701...25,781,290

G

glutamate-cysteine ligase, catalytic subunit

increases expression

n-hexane results in increased expression of GCLC mRNA

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression

n-hexane results in increased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glutaredoxin 2

decreases methylation

n-hexane results in decreased methylation of GLRX2 promoter

NCBI chr13:55,481,875...55,504,737
Ensembl chr13:55,482,694...55,492,831

G

G protein subunit alpha 14

decreases methylation

n-hexane results in decreased methylation of GNA14 promoter

NCBI chr 1:213,714,993...213,900,083
Ensembl chr 1:213,716,020...213,897,423

G

G protein subunit alpha q

decreases methylation

n-hexane results in decreased methylation of GNAQ promoter

NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672

G

golgi SNAP receptor complex member 1

decreases methylation

n-hexane results in decreased methylation of GOSR1 promoter

NCBI chr10:61,570,499...61,607,287
Ensembl chr10:61,450,494...61,607,177
Ensembl chr10:61,450,494...61,607,177

G

glutamate metabotropic receptor 6

decreases methylation

n-hexane results in decreased methylation of GRM6 promoter

NCBI chr10:35,167,985...35,182,717
Ensembl chr10:35,167,985...35,182,717

G

glutathione-disulfide reductase

increases expression

n-hexane results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

heme oxygenase 1

increases expression
multiple interactions

n-hexane results in increased expression of HMOX1 mRNA
[Particulate Matter co-treated with n-hexane] results in increased expression of HMOX1 mRNA

PMID:20566472 PMID:30503853

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hook microtubule-tethering protein 1

decreases methylation

n-hexane results in decreased methylation of HOOK1 promoter

NCBI chr 5:110,824,501...110,887,791
Ensembl chr 5:110,824,501...110,887,787

G

heterochromatin protein 1, binding protein 3

decreases methylation

n-hexane results in decreased methylation of HP1BP3 promoter

NCBI chr 5:150,435,781...150,463,004
Ensembl chr 5:150,433,740...150,463,000

G

interleukin 1 alpha

multiple interactions

[Particulate Matter co-treated with n-hexane] results in increased expression of IL1A mRNA; carazolol promotes the reaction [[Particulate Matter co-treated with n-hexane] results in increased expression of IL1A mRNA]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

[Particulate Matter co-treated with n-hexane] results in increased expression of IL1B mRNA

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

increases expression

n-hexane results in increased expression of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibitor of growth family, member 2

decreases methylation

n-hexane results in decreased methylation of ING2 promoter

NCBI chr16:44,573,592...44,584,180
Ensembl chr16:44,575,597...44,583,482

G

potassium two pore domain channel subfamily K member 1

increases methylation

n-hexane results in increased methylation of KCNK1 promoter

NCBI chr19:53,959,411...53,997,726
Ensembl chr19:53,959,657...53,997,724

G

KH RNA binding domain containing, signal transduction associated 1

decreases methylation

n-hexane results in decreased methylation of KHDRBS1 promoter

NCBI chr 5:142,051,844...142,089,175
Ensembl chr 5:142,063,570...142,089,180

G

kinesin family member 15

increases methylation

n-hexane results in increased methylation of KIF15 promoter

NCBI chr 8:122,601,888...122,672,750
Ensembl chr 8:122,601,897...122,672,750

G

kelch-like family member 21

decreases methylation

n-hexane results in decreased methylation of KLHL21 promoter

NCBI chr 5:162,514,888...162,523,545
Ensembl chr 5:162,514,765...162,523,545

G

keratin 84

decreases methylation

n-hexane results in decreased methylation of KRT84 promoter

NCBI chr 7:132,649,064...132,656,885
Ensembl chr 7:132,649,061...132,656,874

G

leucine zipper and EF-hand containing transmembrane protein 2

decreases methylation

n-hexane results in decreased methylation of LETM2 promoter

NCBI chr16:66,464,958...66,489,640
Ensembl chr16:66,469,111...66,489,704

G

lysyl oxidase-like 4

increases methylation

n-hexane results in increased methylation of LOXL4 promoter

NCBI chr 1:241,396,183...241,416,385
Ensembl chr 1:241,397,983...241,416,322

G

leucine rich repeat and fibronectin type III domain containing 1

increases methylation

n-hexane results in increased methylation of LRFN1 promoter

NCBI chr 1:83,742,442...83,761,450
Ensembl chr 1:83,682,964...83,761,449

G

leucine rich repeat and fibronectin type III domain containing 3

decreases methylation

n-hexane results in decreased methylation of LRFN3 promoter

NCBI chr 1:85,616,862...85,623,725
Ensembl chr 1:85,616,868...85,623,725

G

MAF bZIP transcription factor G

increases expression

n-hexane results in increased expression of MAFG mRNA

NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026

G

membrane associated guanylate kinase, WW and PDZ domain containing 2

increases methylation

n-hexane results in increased methylation of MAGI2 promoter

NCBI chr 4:14,386,389...15,870,036
Ensembl chr 4:14,386,399...15,870,240

G

membrane associated ring-CH-type finger 8

decreases methylation

n-hexane results in decreased methylation of MARCHF8 promoter

NCBI chr 4:149,415,642...149,530,771
Ensembl chr 4:149,416,071...149,530,770

G

MAU2 sister chromatid cohesion factor

decreases methylation

n-hexane results in decreased methylation of MAU2 promoter

NCBI chr16:19,383,847...19,414,996
Ensembl chr16:19,383,492...19,408,727

G

midkine

decreases methylation

n-hexane results in decreased methylation of MDK promoter

NCBI chr 3:77,901,134...77,903,997
Ensembl chr 3:77,901,158...77,903,130

G

malic enzyme 1

increases expression

n-hexane results in increased expression of ME1 mRNA

NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304

G

meiotic double-stranded break formation protein 1

decreases methylation

n-hexane results in decreased methylation of MEI1 promoter

NCBI chr 7:113,590,142...113,643,513
Ensembl chr 7:113,590,142...113,643,511

G

microfibril associated protein 2

decreases methylation

n-hexane results in decreased methylation of MFAP2 promoter

NCBI chr 5:153,312,068...153,320,266
Ensembl chr 5:153,314,711...153,320,259

G

major intrinsic protein of lens fiber

increases methylation

n-hexane results in increased methylation of MIP promoter

NCBI chr 7:643,502...653,121
Ensembl chr 7:647,315...654,400

G

metallophosphoesterase domain containing 2

decreases methylation

n-hexane results in decreased methylation of MPPED2 promoter

NCBI chr 3:93,180,895...93,355,605
Ensembl chr 3:93,181,167...93,355,618

G

NADH:ubiquinone oxidoreductase subunit B4

decreases methylation

n-hexane results in decreased methylation of NDUFB4 promoter

NCBI chr11:63,063,723...63,070,426
Ensembl chr11:63,063,795...63,070,425

G

NADH:ubiquinone oxidoreductase subunit B8

decreases methylation

n-hexane results in decreased methylation of NDUFB8 promoter

NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817

G

nuclear factor of activated T-cells 2 interacting protein

increases methylation

n-hexane results in increased methylation of NFATC2IP promoter

NCBI chr 1:180,954,834...180,971,847
Ensembl chr 1:180,955,043...180,971,747

G

aminopeptidase-like 1

increases methylation

n-hexane results in increased methylation of NPEPL1 promoter

NCBI chr 3:162,893,932...162,906,491
Ensembl chr 3:162,893,943...162,906,492

G

NAD(P)H quinone dehydrogenase 1

increases expression

n-hexane results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

ornithine decarboxylase 1

decreases methylation

n-hexane results in decreased methylation of ODC1 promoter

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

PCI domain containing 2

decreases methylation

n-hexane results in decreased methylation of PCID2 promoter

NCBI chr16:76,423,245...76,448,712
Ensembl chr16:76,423,245...76,448,712

G

phosphogluconate dehydrogenase

increases expression

n-hexane results in increased expression of PGD mRNA

NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778

G

pleckstrin homology-like domain, family A, member 1

decreases methylation

n-hexane results in decreased methylation of PHLDA1 promoter

NCBI chr 7:46,967,433...46,969,637
Ensembl chr 7:46,967,409...46,969,861

G

protein O-glucosyltransferase 3

decreases methylation

n-hexane results in decreased methylation of POGLUT3 promoter

NCBI chr 8:53,777,614...53,795,404
Ensembl chr 8:53,777,785...53,795,399

G

protein phosphatase 1 catalytic subunit beta

decreases methylation

n-hexane results in decreased methylation of PPP1CB promoter

NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824

G

prokineticin 2

decreases methylation

n-hexane results in decreased methylation of PROK2 promoter

NCBI chr 4:132,346,681...132,361,754
Ensembl chr 4:132,347,103...132,361,385

G

pre-mRNA processing factor 19

decreases methylation

n-hexane results in decreased methylation of PRPF19 promoter

NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662

G

phosphoribosyl pyrophosphate synthetase 2

decreases methylation

n-hexane results in decreased methylation of PRPS2 promoter

NCBI chr X:26,975,915...27,013,184
Ensembl chr X:26,976,061...27,013,181

G

prostaglandin reductase 1

increases expression

n-hexane results in increased expression of PTGR1 mRNA

NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Particulate Matter co-treated with n-hexane] results in increased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RAB5B, member RAS oncogene family

decreases methylation

n-hexane results in decreased methylation of RAB5B promoter

NCBI chr 7:1,109,449...1,128,348
Ensembl chr 7:1,109,454...1,128,268

G

RAB, member RAS oncogene family-like 6

decreases methylation

n-hexane results in decreased methylation of RABL6 promoter

NCBI chr 3:8,402,666...8,428,588
Ensembl chr 3:8,402,672...8,428,611

G

RALY heterogeneous nuclear ribonucleoprotein

decreases methylation

n-hexane results in decreased methylation of RALY promoter

NCBI chr 3:143,306,039...143,370,542
Ensembl chr 3:143,306,300...143,370,539

G

receptor accessory protein 1

decreases methylation

n-hexane results in decreased methylation of REEP1 promoter

NCBI chr 4:103,746,004...103,862,347
Ensembl chr 4:103,745,633...103,862,338

G

similar to RIKEN cDNA 1110059G10

increases methylation

n-hexane results in increased methylation of RGD1311745 promoter

NCBI chr 8:122,598,363...122,609,127
Ensembl chr 8:122,598,401...122,609,168

G

RP2 activator of ARL3 GTPase

decreases methylation

n-hexane results in decreased methylation of RP2 promoter

NCBI chr X:1,872,582...1,916,704
Ensembl chr X:1,873,306...1,916,688

G

reprimo, TP53 dependent G2 arrest mediator homolog

increases methylation

n-hexane results in increased methylation of RPRM promoter

NCBI chr 3:38,539,581...38,540,998
Ensembl chr 3:38,539,581...38,540,998

G

ribosomal protein S6 kinase A5

decreases methylation

n-hexane results in decreased methylation of RPS6KA5 promoter

NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224

G

stabilizer of axonemal microtubules 5

decreases methylation

n-hexane results in decreased methylation of SAXO5 promoter

NCBI chr12:1,520,983...1,538,127
Ensembl chr12:1,521,014...1,538,118

G

selenoprotein V

decreases methylation

n-hexane results in decreased methylation of SELENOV promoter

NCBI chr 1:83,551,473...83,558,756
Ensembl chr 1:83,551,473...83,558,756

G

semaphorin 5B

decreases methylation

n-hexane results in decreased methylation of SEMA5B promoter

NCBI chr11:65,102,532...65,225,456
Ensembl chr11:65,102,031...65,225,311

G

serpin family B member 2

multiple interactions

[Particulate Matter co-treated with n-hexane] results in increased expression of SERPINB2 mRNA

NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408

G

SID1 transmembrane family, member 2

decreases methylation

n-hexane results in decreased methylation of SIDT2 promoter

NCBI chr 8:46,232,379...46,248,913
Ensembl chr 8:46,232,383...46,248,700

G

signal-induced proliferation-associated 1 like 3

decreases methylation

n-hexane results in decreased methylation of SIPA1L3 promoter

NCBI chr 1:84,618,714...84,825,956
Ensembl chr 1:84,618,719...84,703,802

G

solute carrier family 27 member 3

decreases methylation

n-hexane results in decreased methylation of SLC27A3 promoter

NCBI chr 2:175,853,241...175,857,909
Ensembl chr 2:175,853,241...175,857,909

G

solute carrier family 39 member 14

increases expression

n-hexane results in increased expression of SLC39A14 mRNA

NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524

G

solute carrier family 40 member 1

decreases expression

n-hexane results in decreased expression of SLC40A1 mRNA

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

G

solute carrier family 47 member 1

decreases methylation

n-hexane results in decreased methylation of SLC47A1 promoter

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 52 member 3

decreases methylation

n-hexane results in decreased methylation of SLC52A3 promoter

NCBI chr 3:140,498,924...140,515,845
Ensembl chr 3:140,509,473...140,514,096

G

solute carrier family 7 member 5

decreases methylation

n-hexane results in decreased methylation of SLC7A5 promoter

NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823

G

solute carrier organic anion transporter family, member 4C1

decreases methylation

n-hexane results in decreased methylation of SLCO4C1 promoter

NCBI chr 9:97,177,497...97,229,161
Ensembl chr 9:97,178,861...97,229,715

G

sulfiredoxin 1

increases expression

n-hexane results in increased expression of SRXN1 mRNA

NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448

G

steroidogenic acute regulatory protein

affects expression
affects methylation

n-hexane affects the expression of STAR mRNA; n-hexane affects the expression of STAR protein
n-hexane affects the methylation of STAR promoter

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

SURP and G patch domain containing 1

decreases methylation

n-hexane results in decreased methylation of SUGP1 promoter

NCBI chr16:19,352,659...19,383,533
Ensembl chr16:19,351,793...19,383,756

G

synaptogyrin 1

decreases methylation

n-hexane results in decreased methylation of SYNGR1 promoter

NCBI chr 7:111,635,911...111,659,341
Ensembl chr 7:111,635,918...111,659,341

G

tumor-associated calcium signal transducer 2

increases methylation

n-hexane results in increased methylation of TACSTD2 promoter

NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650

G

tubulin folding cofactor B

increases methylation

n-hexane results in increased methylation of TBCB promoter

NCBI chr 1:85,477,639...85,483,488
Ensembl chr 1:85,477,640...85,483,488

G

transmembrane protein 14C

decreases methylation

n-hexane results in decreased methylation of TMEM14C promoter

NCBI chr17:23,733,769...23,739,906
Ensembl chr17:23,733,894...23,753,320

G

TSPY-like 4

decreases methylation

n-hexane results in decreased methylation of TSPYL4 promoter

NCBI chr20:38,098,756...38,100,752
Ensembl chr20:38,098,677...38,103,053

G

thioredoxin reductase 1

increases expression

n-hexane results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

ubiquitin specific peptidase 11

increases methylation

n-hexane results in increased methylation of USP11 promoter

NCBI chr X:1,473,349...1,489,520
Ensembl chr X:1,473,350...1,489,520

G

vascular endothelial growth factor C

decreases methylation

n-hexane results in decreased methylation of VEGFC promoter

NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848

G

vimentin

multiple interactions

n-hexane metabolite promotes the reaction [VIM protein binds to VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

V-set and transmembrane domain containing 4

decreases methylation

n-hexane results in decreased methylation of VSTM4 promoter

NCBI chr16:8,120,336...8,200,272
Ensembl chr16:8,120,336...8,200,269

G

WW domain containing E3 ubiquitin protein ligase 1

decreases methylation

n-hexane results in decreased methylation of WWP1 promoter

NCBI chr 5:33,092,379...33,185,887
Ensembl chr 5:33,098,494...33,186,046

G

zinc finger protein 593

increases methylation

n-hexane results in increased methylation of ZFP593 promoter

NCBI chr 5:146,462,670...146,464,998
Ensembl chr 5:146,462,670...146,465,198

G

ZPR1 zinc finger

decreases methylation

n-hexane results in decreased methylation of ZPR1 promoter

NCBI chr 8:46,564,898...46,574,719
Ensembl chr 8:46,565,146...46,574,719

2,5-hexanedione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

abl-interactor 2

increases expression

2,5-hexanedione results in increased expression of ABI2 mRNA

PMID:22952946 PMID:27466211

NCBI chr 9:61,827,186...61,905,703
Ensembl chr 9:61,827,139...61,905,699

G

aconitase 2

increases expression

2,5-hexanedione results in increased expression of ACO2 protein

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

G

alpha-2-HS-glycoprotein

decreases expression

2,5-hexanedione results in decreased expression of AHSG protein

NCBI chr11:78,121,388...78,127,998
Ensembl chr11:78,117,918...78,145,999

G

allograft inflammatory factor 1

increases expression
multiple interactions

2,5-hexanedione results in increased expression of AIF1 protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of AIF1 protein]

PMID:32522579 PMID:32860822

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

AKT serine/threonine kinase 1

decreases phosphorylation
increases expression

2,5-hexanedione results in decreased phosphorylation of AKT1 protein
2,5-hexanedione results in increased expression of AKT1 mRNA

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

arachidonate 15-lipoxygenase, type B

decreases expression

2,5-hexanedione results in decreased expression of ALOX15B mRNA

NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812

G

angiopoietin-like 4

affects expression

2,5-hexanedione affects the expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

G

apolipoprotein A4

decreases expression

2,5-hexanedione results in decreased expression of APOA4 protein

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

arginase 1

decreases expression
multiple interactions

2,5-hexanedione results in decreased expression of ARG1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of ARG1 mRNA]

PMID:32522579 PMID:32860822

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

argininosuccinate synthase 1

increases expression

2,5-hexanedione results in increased expression of ASS1 protein

NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903

G

ATP synthase F1 subunit alpha

affects expression

2,5-hexanedione affects the expression of ATP5F1A protein

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

G

BCL2 associated X, apoptosis regulator

increases expression

2,5-hexanedione results in increased expression of BAX mRNA; 2,5-hexanedione results in increased expression of BAX protein

PMID:17492505 PMID:21901545 PMID:22337490

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

increases expression
decreases expression

2,5-hexanedione results in increased expression of BCL2 protein
2,5-hexanedione results in decreased expression of BCL2 mRNA
2,5-hexanedione results in decreased expression of BCL2 mRNA; 2,5-hexanedione results in decreased expression of BCL2 protein

PMID:17492505 PMID:21901545 PMID:22337490

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 14

increases expression

2,5-hexanedione results in increased expression of BCL2L14 mRNA

NCBI chr 4:167,217,561...167,258,723
Ensembl chr 4:167,219,871...167,258,086

G

brain-derived neurotrophic factor

decreases expression

2,5-hexanedione results in decreased expression of BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

bifunctional apoptosis regulator

increases expression

2,5-hexanedione results in increased expression of BFAR mRNA

NCBI chr10:1,552,019...1,585,040
Ensembl chr10:1,552,072...1,585,038

G

caspase 1

increases cleavage
increases expression
multiple interactions

2,5-hexanedione results in increased cleavage of CASP1 protein
2,5-hexanedione results in increased expression of CASP1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of CASP1 protein]

PMID:32522579 PMID:32860822

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

increases expression

2,5-hexanedione results in increased expression of CASP3 mRNA; 2,5-hexanedione results in increased expression of CASP3 protein alternative form

PMID:17492505 PMID:21901545

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

decreases expression

2,5-hexanedione results in decreased expression of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

increases expression

2,5-hexanedione results in increased expression of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

coiled-coil domain containing 171

increases expression

2,5-hexanedione results in increased expression of CCDC171 mRNA

NCBI chr 5:97,919,965...98,403,853
Ensembl chr 5:97,920,002...98,282,833

G

coiled-coil domain containing 191

increases expression

2,5-hexanedione results in increased expression of CCDC191 mRNA

NCBI chr11:56,735,655...56,806,372
Ensembl chr11:56,735,652...56,806,375

G

CDAN1 interacting nuclease 1

increases expression

2,5-hexanedione results in increased expression of CDIN1 mRNA

NCBI chr 3:102,441,553...102,646,935
Ensembl chr 3:102,441,704...102,646,682

G

centrosomal protein 112

increases expression

2,5-hexanedione results in increased expression of CEP112 mRNA

NCBI chr10:93,366,059...93,833,133
Ensembl chr10:93,366,136...93,833,131

G

carboxylesterase 1D

increases expression

2,5-hexanedione results in increased expression of CES1D protein

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

cilia and flagella associated protein 221

increases expression

2,5-hexanedione results in increased expression of CFAP221 mRNA

NCBI chr13:31,046,550...31,118,141
Ensembl chr13:31,046,535...31,116,899

G

creatine kinase, mitochondrial 1

increases expression

2,5-hexanedione results in increased expression of CKMT1B protein

NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758

G

chloride channel accessory 2

multiple interactions

[carbendazim co-treated with 2,5-hexanedione] results in decreased expression of CLCA2 mRNA

NCBI chr 2:233,993,619...234,022,691
Ensembl chr 2:233,995,078...234,022,199

G

clusterin

decreases expression
increases expression

2,5-hexanedione results in decreased expression of CLU mRNA
2,5-hexanedione results in increased expression of CLU mRNA

PMID:22952946 PMID:27466211

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

cortexin 1

increases expression

2,5-hexanedione results in increased expression of CTXN1 mRNA

NCBI chr12:2,610,465...2,612,076

G

decorin

increases expression

2,5-hexanedione results in increased expression of DCN mRNA

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

DENN domain containing 1A

increases expression

2,5-hexanedione results in increased expression of DENND1A mRNA

NCBI chr 3:21,564,749...22,052,057
Ensembl chr 3:21,564,749...22,052,062

G

dicer 1 ribonuclease III

increases expression

2,5-hexanedione results in increased expression of DICER1 mRNA

NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965

G

dynein axonemal assembly factor 11

increases expression

2,5-hexanedione results in increased expression of DNAAF11 mRNA

NCBI chr 7:98,141,525...98,245,906
Ensembl chr 7:98,144,763...98,245,837

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression

2,5-hexanedione results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

dipeptidylpeptidase 7

multiple interactions

[carbendazim co-treated with 2,5-hexanedione] results in decreased expression of DPP7 mRNA

NCBI chr 3:8,165,091...8,169,343
Ensembl chr 3:8,165,091...8,169,355

G

dihydropyrimidinase-like 2

decreases expression

2,5-hexanedione results in decreased expression of DPYSL2 protein

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

G

epidermal growth factor receptor

increases expression

2,5-hexanedione results in increased expression of EGFR mRNA

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

ELKS/RAB6-interacting/CAST family member 1

increases expression

2,5-hexanedione results in increased expression of ERC1 mRNA

NCBI chr 4:152,763,664...153,055,724
Ensembl chr 4:152,767,419...153,055,639

G

Fas ligand

increases expression

2,5-hexanedione results in increased expression of FASLG mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

decreases expression

2,5-hexanedione results in decreased expression of FASN protein

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

Fc epsilon receptor Ig

increases expression

2,5-hexanedione results in increased expression of FCER1G mRNA

NCBI chr13:83,649,447...83,654,248
Ensembl chr13:83,649,449...83,671,443

G

forkhead box O3

increases phosphorylation
decreases expression

2,5-hexanedione results in increased phosphorylation of FOXO3 protein
2,5-hexanedione results in decreased expression of FOXO3 mRNA

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

growth arrest and DNA-damage-inducible, alpha

increases expression

2,5-hexanedione results in increased expression of GADD45 mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

2,5-hexanedione results in decreased expression of GAPDH protein

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

growth arrest-specific 2

increases expression

2,5-hexanedione results in increased expression of GAS2 mRNA

NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619

G

glial fibrillary acidic protein

decreases expression
increases expression

2,5-hexanedione results in decreased expression of GFAP protein
2,5-hexanedione results in increased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

growth hormone secretagogue receptor

affects expression

2,5-hexanedione affects the expression of GHSR mRNA

NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865

G

glutamate dehydrogenase 1

increases expression

2,5-hexanedione results in increased expression of GLUD1 protein

NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957

G

gasdermin D

multiple interactions
increases cleavage

Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of GSDMD protein]

PMID:32522579 PMID:32860822

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

glycogen synthase kinase 3 beta

decreases expression

2,5-hexanedione results in decreased expression of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

gelsolin

decreases expression

2,5-hexanedione results in decreased expression of GSN protein

NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402

G

glutathione S-transferase, mu 5-like

decreases expression

2,5-hexanedione results in decreased expression of GSTM5 protein

NCBI chr 2:195,544,424...195,549,895
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase omega 1

decreases expression

2,5-hexanedione results in decreased expression of GSTO1 protein

NCBI chr 1:246,721,089...246,731,228
Ensembl chr 1:246,721,221...246,731,468

G

glutathione S-transferase pi 1

decreases expression

2,5-hexanedione results in decreased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

hemoglobin alpha, adult chain 2

decreases expression

2,5-hexanedione results in decreased expression of HBA1 protein

NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392

G

hemoglobin subunit beta

decreases expression

2,5-hexanedione results in decreased expression of HBB protein

NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012

G

hemoglobin subunit beta like 1

decreases expression

2,5-hexanedione results in decreased expression of HBBL1 protein

NCBI chr 1:158,236,972...158,238,348
Ensembl chr 1:158,120,200...158,252,012
Ensembl chr 1:158,120,200...158,252,012

G

HDGF like 1

decreases expression

2,5-hexanedione results in decreased expression of HDGFL1 mRNA

NCBI chr17:38,207,906...38,209,902

G

heat shock protein family A (Hsp70) member 1B

increases expression

2,5-hexanedione results in increased expression of HSPA1B mRNA

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 2

affects expression

2,5-hexanedione affects the expression of HSPA2 protein

NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287

G

immediate early response 3

affects expression

2,5-hexanedione affects the expression of IER3 mRNA

NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583

G

intraflagellar transport 81

increases expression

2,5-hexanedione results in increased expression of IFT81 mRNA

NCBI chr12:33,957,744...34,037,164
Ensembl chr12:33,957,806...34,037,057

G

insulin-like growth factor binding protein 3

decreases expression

2,5-hexanedione results in decreased expression of IGFBP3 mRNA

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

interleukin 1 beta

increases expression
multiple interactions

2,5-hexanedione results in increased expression of IL1B mRNA; 2,5-hexanedione results in increased expression of IL1B protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of IL1B protein]

PMID:16141653 PMID:32522579 PMID:32860822

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

internexin neuronal intermediate filament protein, alpha

decreases expression

2,5-hexanedione results in decreased expression of INA protein

NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330

G

integrin subunit alpha M

increases expression
multiple interactions

2,5-hexanedione results in increased expression of ITGAM protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of ITGAM protein]

PMID:19464574 PMID:32522579 PMID:32860822

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

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integrin subunit beta 1

decreases expression

2,5-hexanedione results in decreased expression of ITGB1 mRNA

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

isovaleryl-CoA dehydrogenase

decreases expression

2,5-hexanedione results in decreased expression of IVD protein

NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575

G

KIAA0930 homolog

increases expression

2,5-hexanedione results in increased expression of KIAA0930 mRNA

NCBI chr 7:116,067,974...116,107,678
Ensembl chr 7:116,071,447...116,107,727

G

KIAA1328 homolog

increases expression

2,5-hexanedione results in increased expression of KIAA1328 mRNA

NCBI chr18:16,488,569...16,776,373
Ensembl chr18:16,489,408...16,775,548

G

kinesin family member 6

increases expression

2,5-hexanedione results in increased expression of KIF6 mRNA

NCBI chr 9:11,076,203...11,373,205
Ensembl chr 9:11,072,824...11,373,006

G

KIT proto-oncogene receptor tyrosine kinase

decreases expression
multiple interactions

2,5-hexanedione results in decreased expression of KIT protein
resveratrol inhibits the reaction [2,5-hexanedione results in decreased expression of KIT protein]

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

G

lamin A/C

increases expression

2,5-hexanedione results in increased expression of LMNA protein

NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423

G

lysyl oxidase-like 1

increases expression
multiple interactions

2,5-hexanedione results in increased expression of LOXL1 protein
2,5-hexanedione promotes the reaction [carbendazim results in increased expression of LOXL1 protein]; [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of LOXL1 mRNA

NCBI chr 8:58,691,763...58,716,365
Ensembl chr 8:58,692,593...58,716,356

G

leucine rich repeat containing 69

increases expression

2,5-hexanedione results in increased expression of LRRC69 mRNA

NCBI chr 5:28,023,591...28,181,963
Ensembl chr 5:28,023,593...28,214,384

G

lysozyme 2

decreases expression
increases expression

2,5-hexanedione results in decreased expression of LYZ2 mRNA
2,5-hexanedione results in increased expression of LYZ2 mRNA

NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106

G

mono-ADP ribosylhydrolase 1

increases expression
multiple interactions

2,5-hexanedione results in increased expression of MACROD1 mRNA
[carbendazim co-treated with 2,5-hexanedione] results in decreased expression of MACROD1 mRNA

NCBI chr 1:204,246,238...204,387,027
Ensembl chr 1:204,246,166...204,389,716

G

microtubule-associated protein 1A

decreases expression

2,5-hexanedione results in decreased expression of MAP1A protein

NCBI chr 3:108,263,217...108,283,936
Ensembl chr 3:108,263,151...108,282,899

G

microtubule-associated protein 1B

decreases expression

2,5-hexanedione results in decreased expression of MAP1B protein; 2,5-hexanedione results in decreased expression of MAP1B protein modified form

PMID:20554699 PMID:31760062

NCBI chr 2:30,817,261...30,910,458
Ensembl chr 2:30,817,261...30,910,317

G

microtubule-associated protein 2

decreases expression

2,5-hexanedione results in decreased expression of MAP2 protein modified form

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen-activated protein kinase kinase kinase 1

increases expression

2,5-hexanedione results in increased expression of MAP3K1 protein

NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463

G

microtubule-associated protein tau

decreases expression

2,5-hexanedione results in decreased expression of MAPT protein modified form

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

myelin basic protein

multiple interactions
decreases expression

Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MBP protein]

PMID:32522579 PMID:32860822

NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404

G

malate dehydrogenase 1

increases expression

2,5-hexanedione results in increased expression of MDH1 protein

NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925

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microfibril associated protein 3 like

increases expression

2,5-hexanedione results in increased expression of MFAP3L mRNA

NCBI chr16:29,411,643...29,454,665
Ensembl chr16:29,415,849...29,430,863

G

microRNA 10b

increases expression

2,5-hexanedione results in increased expression of MIR10B mRNA

NCBI chr 3:59,628,438...59,628,546
Ensembl chr 3:59,628,438...59,628,546

G

microRNA 1224

increases expression

2,5-hexanedione results in increased expression of MIR1224 mRNA

NCBI chr11:80,306,902...80,306,986
Ensembl chr11:80,306,902...80,306,986

G

microRNA 125a

increases expression
decreases expression

2,5-hexanedione results in increased expression of MIR125A mRNA
2,5-hexanedione results in decreased expression of MIR125A mRNA

NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710

G

microRNA 130b

decreases expression

2,5-hexanedione results in decreased expression of MIR130B mRNA

NCBI chr11:83,880,163...83,880,244
Ensembl chr11:83,880,163...83,880,244

G

microRNA 134

decreases expression

2,5-hexanedione results in decreased expression of MIR134 mRNA

NCBI chr 6:128,748,908...128,748,980

G

microRNA 155

decreases expression

2,5-hexanedione results in decreased expression of MIR155 mRNA

NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718

G

microRNA 183

decreases expression

2,5-hexanedione results in decreased expression of MIR183 mRNA

NCBI chr 4:58,788,614...58,788,723
Ensembl chr 4:58,788,614...58,788,723

G

microRNA 193

increases expression

2,5-hexanedione results in increased expression of MIR193 mRNA

NCBI chr10:64,672,354...64,672,439

G

microRNA 193a

decreases expression

2,5-hexanedione results in decreased expression of MIR193A mRNA

NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454

G

microRNA 194-2

decreases expression

2,5-hexanedione results in decreased expression of MIR194-2 mRNA

NCBI chr 1:203,564,761...203,564,845
Ensembl chr 1:203,564,761...203,564,845

G

microRNA 196a

increases expression

2,5-hexanedione results in increased expression of MIR196A mRNA

NCBI chr 7:134,110,400...134,110,509
Ensembl chr 7:134,110,400...134,110,509

G

microRNA 196c

increases expression

2,5-hexanedione results in increased expression of MIR196C mRNA

NCBI chr10:81,231,006...81,231,085
Ensembl chr10:81,231,006...81,231,085

G

microRNA 199a-2

decreases expression

2,5-hexanedione results in decreased expression of MIR199A-2 mRNA; 2,5-hexanedione results in decreased expression of MIR199A2 mRNA

NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063

G

microRNA 200c

decreases expression

2,5-hexanedione results in decreased expression of MIR200C mRNA

NCBI chr 4:157,523,679...157,523,747

G

microRNA 202

decreases expression

2,5-hexanedione results in decreased expression of MIR202 mRNA

NCBI chr 1:194,754,730...194,754,801
Ensembl chr 1:194,754,730...194,754,801

G

microRNA 206

decreases expression

2,5-hexanedione results in decreased expression of MIR206 mRNA

NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332

G

microRNA 208a

increases expression

2,5-hexanedione results in increased expression of MIR208A mRNA

NCBI chr15:28,425,570...28,425,652

G

microRNA 20a

decreases expression

2,5-hexanedione results in decreased expression of MIR20A mRNA

NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168

G

microRNA 21

increases expression
decreases expression

2,5-hexanedione results in increased expression of MIR21 mRNA
2,5-hexanedione results in decreased expression of MIR21 mRNA

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 212

increases expression

2,5-hexanedione results in increased expression of MIR212 mRNA

NCBI chr10:60,023,403...60,023,513
Ensembl chr10:60,023,403...60,023,513

G

microRNA 214

increases expression

2,5-hexanedione results in increased expression of MIR214 mRNA

NCBI chr13:74,588,374...74,588,481
Ensembl chr13:74,588,372...74,588,481

G

microRNA 22

increases expression

2,5-hexanedione results in increased expression of MIR22 mRNA

NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133

G

microRNA 223

increases expression

2,5-hexanedione results in increased expression of MIR223 mRNA

NCBI chr X:61,141,887...61,141,996
Ensembl chr X:61,141,887...61,141,996

G

microRNA 224

increases expression

2,5-hexanedione results in increased expression of MIR224 mRNA

NCBI chr X:150,065,088...150,065,169
Ensembl chr X:150,065,088...150,065,169

G

microRNA 27a

decreases expression

2,5-hexanedione results in decreased expression of MIR27A mRNA

NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917

G

microRNA 27b

increases expression

2,5-hexanedione results in increased expression of MIR27B mRNA

NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529

G

microRNA 300

increases expression

2,5-hexanedione results in increased expression of MIR300 mRNA

NCBI chr 6:128,738,513...128,738,591
Ensembl chr 6:128,738,505...128,738,594

G

microRNA 30a

increases expression

2,5-hexanedione results in increased expression of MIR30A mRNA

NCBI chr 9:25,737,600...25,737,670
Ensembl chr 9:25,737,600...25,737,670

G

microRNA 32

increases expression

2,5-hexanedione results in increased expression of MIR32 mRNA

NCBI chr 5:71,596,083...71,596,152
Ensembl chr 5:71,596,083...71,596,152

G

microRNA 320a

increases expression

2,5-hexanedione results in increased expression of MIR320A mRNA

NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473

G

microRNA 323

decreases expression

2,5-hexanedione results in decreased expression of MIR323 mRNA

NCBI chr 6:128,725,539...128,725,624
Ensembl chr 6:128,725,539...128,725,624

G

microRNA 326

increases expression

2,5-hexanedione results in increased expression of MIR326 mRNA

NCBI chr 1:153,854,029...153,854,123
Ensembl chr 1:153,854,029...153,854,123

G

microRNA 33

increases expression

2,5-hexanedione results in increased expression of MIR33 mRNA

NCBI chr 7:113,713,855...113,713,923
Ensembl chr 7:113,713,855...113,713,923

G

microRNA 330

increases expression

2,5-hexanedione results in increased expression of MIR330 mRNA

NCBI chr 1:78,833,178...78,833,274
Ensembl chr 1:78,833,178...78,833,274

G

microRNA 331

decreases expression

2,5-hexanedione results in decreased expression of MIR331 mRNA

NCBI chr 7:28,527,390...28,527,485
Ensembl chr 7:28,527,390...28,527,485

G

microRNA 339

increases expression

2,5-hexanedione results in increased expression of MIR339 mRNA

NCBI chr12:15,277,546...15,277,641
Ensembl chr12:15,277,546...15,277,641

G

microRNA 344-1

decreases expression

2,5-hexanedione results in decreased expression of MIR344-1 mRNA

NCBI chr 1:115,306,861...115,306,958

G

microRNA 345

increases expression

2,5-hexanedione results in increased expression of MIR345 mRNA

NCBI chr 6:127,754,027...127,754,122
Ensembl chr 6:127,754,027...127,754,122

G

microRNA 3556a

decreases expression

2,5-hexanedione results in decreased expression of MIR3556A mRNA

NCBI chr 4:59,650,596...59,650,713
Ensembl chr 4:59,650,596...59,650,713

G

microRNA 3558

decreases expression

2,5-hexanedione results in decreased expression of MIR3558 mRNA

NCBI chr 6:7,181,751...7,181,864
Ensembl chr 6:7,181,751...7,181,864

G

microRNA 3560

decreases expression

2,5-hexanedione results in decreased expression of MIR3560 mRNA

NCBI chr X:15,255,308...15,255,419
Ensembl chr X:15,255,308...15,255,419

G

microRNA 3573

increases expression

2,5-hexanedione results in increased expression of MIR3573 mRNA

NCBI chr X:64,259,096...64,259,167
Ensembl chr X:64,259,096...64,259,167

G

microRNA 3580

decreases expression

2,5-hexanedione results in decreased expression of MIR3580 mRNA

NCBI chr X:145,445,018...145,445,098
Ensembl chr X:145,445,018...145,445,098

G

microRNA 3593

decreases expression

2,5-hexanedione results in decreased expression of MIR3593 mRNA

NCBI chr 6:73,252,647...73,252,737
Ensembl chr 6:73,252,647...73,252,737

G

microRNA 370

decreases expression

2,5-hexanedione results in decreased expression of MIR370 mRNA

NCBI chr 6:128,572,257...128,572,335
Ensembl chr 6:128,572,257...128,572,335

G

microRNA 375

decreases expression

2,5-hexanedione results in decreased expression of MIR375 mRNA

NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985

G

microRNA 412

increases expression

2,5-hexanedione results in increased expression of MIR412 mRNA

NCBI chr 6:128,757,932...128,758,001
Ensembl chr 6:128,757,926...128,758,005

G

microRNA 423

increases expression

2,5-hexanedione results in increased expression of MIR423 mRNA

NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226

G

microRNA 433

decreases expression

2,5-hexanedione results in decreased expression of MIR433 mRNA

NCBI chr 6:128,545,119...128,545,211
Ensembl chr 6:128,545,112...128,545,217

G

microRNA 450a-1

decreases expression

2,5-hexanedione results in decreased expression of MIR450A1 mRNA

NCBI chr X:132,801,380...132,801,470
Ensembl chr X:132,801,380...132,801,470

G

microRNA 487b

increases expression

2,5-hexanedione results in increased expression of MIR487B mRNA

NCBI chr 6:128,741,485...128,741,566
Ensembl chr 6:128,741,485...128,741,566

G

microRNA 488

increases expression

2,5-hexanedione results in increased expression of MIR488 mRNA

NCBI chr13:70,683,064...70,683,142
Ensembl chr13:70,683,064...70,683,142

G

microRNA 497

decreases expression

2,5-hexanedione results in decreased expression of MIR497 mRNA

NCBI chr10:54,951,514...54,951,582
Ensembl chr10:54,951,505...54,951,584

G

microRNA 503

decreases expression

2,5-hexanedione results in decreased expression of MIR503 mRNA

NCBI chr X:132,806,303...132,806,373
Ensembl chr X:132,806,303...132,806,373

G

microRNA 541

decreases expression

2,5-hexanedione results in decreased expression of MIR541 mRNA

NCBI chr 6:128,757,016...128,757,105
Ensembl chr 6:128,757,016...128,757,105

G

microRNA 542

increases expression

2,5-hexanedione results in increased expression of MIR542 mRNA

NCBI chr X:132,802,623...132,802,701
Ensembl chr X:132,802,623...132,802,701

G

microRNA 551b

decreases expression

2,5-hexanedione results in decreased expression of MIR551B mRNA

NCBI chr 2:113,989,203...113,989,300
Ensembl chr 2:113,989,203...113,989,300

G

microRNA 582

increases expression

2,5-hexanedione results in increased expression of MIR582 mRNA

NCBI chr 2:40,928,571...40,928,651
Ensembl chr 2:40,928,571...40,928,651

G

microRNA 652

decreases expression

2,5-hexanedione results in decreased expression of MIR652 mRNA

NCBI chr X:106,343,293...106,343,373
Ensembl chr X:106,343,293...106,343,373

G

microRNA 653

decreases expression

2,5-hexanedione results in decreased expression of MIR653 mRNA

NCBI chr 4:31,692,714...31,692,810
Ensembl chr 4:31,692,714...31,692,810

G

microRNA 665

increases expression

2,5-hexanedione results in increased expression of MIR665 mRNA

NCBI chr 6:128,539,440...128,539,533
Ensembl chr 6:128,539,440...128,539,533

G

microRNA 675

increases expression

2,5-hexanedione results in increased expression of MIR675 mRNA

NCBI chr 1:197,732,275...197,732,358
Ensembl chr 1:197,732,275...197,732,358

G

microRNA 743a

increases expression

2,5-hexanedione results in increased expression of MIR743A mRNA

NCBI chr X:145,402,692...145,402,767
Ensembl chr X:145,402,692...145,402,767

G

microRNA 760

decreases expression

2,5-hexanedione results in decreased expression of MIR760 mRNA

NCBI chr 2:210,392,616...210,392,695
Ensembl chr 2:210,392,616...210,392,695

G

microRNA 770

increases expression

2,5-hexanedione results in increased expression of MIR770 mRNA

NCBI chr 6:128,515,843...128,515,918
Ensembl chr 6:128,515,835...128,515,928

G

microRNA 8

increases expression

2,5-hexanedione results in increased expression of MIR8 mRNA

NCBI chr 1:132,806,420...132,806,514
Ensembl chr 1:132,806,420...132,806,514

G

microRNA 873

increases expression

2,5-hexanedione results in increased expression of MIR873 mRNA

NCBI chr 5:51,356,919...51,356,995
Ensembl chr 5:51,356,919...51,356,995

G

microRNA 877

increases expression

2,5-hexanedione results in increased expression of MIR877 mRNA

NCBI chr20:2,811,476...2,811,560
Ensembl chr20:2,811,476...2,811,560

G

microRNA 883

decreases expression

2,5-hexanedione results in decreased expression of MIR883 mRNA

NCBI chr X:145,410,566...145,410,642
Ensembl chr X:145,410,566...145,410,642

G

microRNA let-7b

increases expression

2,5-hexanedione results in increased expression of MIRLET7B mRNA

NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270

G

microRNA let7f-1

decreases expression

2,5-hexanedione results in decreased expression of MIRLET7F1 mRNA

NCBI chr17:16,114,130...16,114,226
Ensembl chr17:16,114,130...16,114,226

G

microRNA let-7i

increases expression

2,5-hexanedione results in increased expression of MIRLET7I mRNA

NCBI chr 7:58,642,485...58,642,569
Ensembl chr 7:58,642,480...58,642,571

G

mannose receptor, C type 1

decreases expression
multiple interactions

2,5-hexanedione results in decreased expression of MRC1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MRC1 mRNA]

PMID:32522579 PMID:32860822

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

G

myotubularin 1

increases expression

2,5-hexanedione results in increased expression of MTM1 mRNA

NCBI chr 6:488,923...506,882
Ensembl chr 6:488,969...506,860

G

NSF attachment protein alpha

decreases expression

2,5-hexanedione results in decreased expression of NAPA protein

NCBI chr 1:76,787,036...76,805,869
Ensembl chr 1:76,786,932...76,805,869

G

NADH:ubiquinone oxidoreductase subunit A10

increases expression
decreases expression

2,5-hexanedione results in increased expression of NDUFA10 protein
2,5-hexanedione results in decreased expression of NDUFA10 protein

NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560

G

NADH:ubiquinone oxidoreductase core subunit V2

decreases expression

2,5-hexanedione results in decreased expression of NDUFV2 protein

NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713

G

neurofilament heavy chain

decreases expression

2,5-hexanedione results in decreased expression of NEFH protein

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

neurofilament light chain

decreases expression
multiple interactions

2,5-hexanedione results in decreased expression of NEFL protein
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of NEFL protein]

PMID:19033394 PMID:32522579 PMID:32860822

NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793

G

neurofilament medium chain

decreases expression

2,5-hexanedione results in decreased expression of NEFM protein

NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755

G

NLR family, pyrin domain containing 3

multiple interactions
increases expression

Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NLRP3 protein]
2,5-hexanedione results in increased expression of NLRP3 mRNA; 2,5-hexanedione results in increased expression of NLRP3 protein

PMID:32522579 PMID:32860822

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

increases expression
multiple interactions

2,5-hexanedione results in increased expression of NOS2 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NOS2 mRNA]

PMID:32522579 PMID:32860822

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

decreases expression

2,5-hexanedione results in decreased expression of NSF protein

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

NSFL1 cofactor

increases expression

2,5-hexanedione results in increased expression of NSFL1C protein

NCBI chr 3:139,978,306...140,002,876
Ensembl chr 3:139,978,301...140,002,870

G

nuclear protein 2, transcriptional regulator

increases expression

2,5-hexanedione results in increased expression of NUPR2 mRNA

NCBI chr12:26,800,123...26,803,228
Ensembl chr12:26,799,800...26,803,304

G

protein disulfide isomerase family A, member 3

decreases expression
increases expression

2,5-hexanedione results in decreased expression of PDIA3 protein
2,5-hexanedione results in increased expression of PDIA3 protein

PMID:15928459 PMID:19033394

NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236

G

PDZ and LIM domain 1

increases expression

2,5-hexanedione results in increased expression of PDLIM1 protein

NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076

G

PDZ and LIM domain 3

decreases expression

2,5-hexanedione results in decreased expression of PDLIM3 protein

NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657

G

pyridoxal phosphatase

decreases expression

2,5-hexanedione results in decreased expression of PDXP protein

NCBI chr 7:110,472,515...110,477,963
Ensembl chr 7:110,472,515...110,477,963

G

phosphatidylethanolamine binding protein 1

decreases expression

2,5-hexanedione results in decreased expression of PEBP1 protein

NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862

G

phosphoglycerate mutase 1

increases expression

2,5-hexanedione results in increased expression of PGAM1 protein

NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452

G

phosphoglycerate dehydrogenase

increases expression

2,5-hexanedione results in increased expression of PHGDH protein

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

phosphoethanolamine/phosphocholine phosphatase 1

increases expression

2,5-hexanedione results in increased expression of PHOSPHO1 mRNA

NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

decreases expression

2,5-hexanedione results in decreased expression of PIK3CA mRNA

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phosphoinositide-3-kinase regulatory subunit 1

decreases expression

2,5-hexanedione results in decreased expression of PIK3R1 protein

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

Pim-1 proto-oncogene, serine/threonine kinase

increases expression

2,5-hexanedione results in increased expression of PIM1 mRNA

NCBI chr20:7,554,921...7,559,174
Ensembl chr20:7,554,921...7,559,174

G

pyruvate kinase M1/2

increases expression

2,5-hexanedione results in increased expression of PKM protein

PMID:15928459 PMID:19033394

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

POU class 2 homeobox 1

increases expression

2,5-hexanedione results in increased expression of POU2F1 mRNA

NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363

G

PRKCSH beta subunit of glucosidase II

decreases expression

2,5-hexanedione results in decreased expression of PRKCSH protein

NCBI chr 8:20,534,787...20,546,493
Ensembl chr 8:20,534,880...20,546,492

G

proteasome 20S subunit alpha 3

decreases expression

2,5-hexanedione results in decreased expression of PSMA3 protein

NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965

G

proteasome 20S subunit alpha 5

decreases expression

2,5-hexanedione results in decreased expression of PSMA5 protein

NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731

G

prostaglandin D2 synthase

increases expression

2,5-hexanedione results in increased expression of PTGDS mRNA

PMID:22952946 PMID:27466211

NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833

G

PYD and CARD domain containing

increases expression

2,5-hexanedione results in increased expression of PYCARD mRNA; 2,5-hexanedione results in increased expression of PYCARD protein

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

glycogen phosphorylase B

decreases expression

2,5-hexanedione results in decreased expression of PYGB protein

NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553

G

glycogen phosphorylase, muscle associated

decreases expression

2,5-hexanedione results in decreased expression of PYGM protein

NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368

G

Ral GTPase activating protein catalytic subunit alpha 2

increases expression

2,5-hexanedione results in increased expression of RALGAPA2 mRNA

NCBI chr 3:133,658,725...133,938,821
Ensembl chr 3:133,659,761...133,938,916

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

2,5-hexanedione results in decreased expression of and affects the localization of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

rhotekin 2

increases expression

2,5-hexanedione results in increased expression of RTKN2 mRNA

NCBI chr20:20,536,628...20,609,951
Ensembl chr20:20,525,256...20,609,951

G

S100 calcium binding protein Z

increases expression

2,5-hexanedione results in increased expression of S100Z mRNA

NCBI chr 2:26,737,796...26,753,611
Ensembl chr 2:26,738,776...26,752,390

G

sodium channel and clathrin linker 1

increases expression

2,5-hexanedione results in increased expression of SCLT1 mRNA

NCBI chr 2:124,605,445...124,763,964
Ensembl chr 2:124,605,658...124,764,065

G

septin 8

decreases expression

2,5-hexanedione results in decreased expression of SEPTIN8 protein

NCBI chr10:37,684,649...37,713,704
Ensembl chr10:37,684,639...37,713,174

G

serine (or cysteine) peptidase inhibitor, clade A, member 3L

decreases expression

2,5-hexanedione results in decreased expression of SERPINA3L protein

NCBI chr 6:123,298,365...123,305,804
Ensembl chr 6:123,298,437...123,312,529

G

SH2 domain containing 4A

decreases expression

2,5-hexanedione results in decreased expression of SH2D4A mRNA

NCBI chr16:21,339,010...21,409,360
Ensembl chr16:21,340,015...21,409,260

G

SH3 domain containing GRB2 like 1, endophilin A2

decreases expression

2,5-hexanedione results in decreased expression of SH3GL1 protein

NCBI chr 9:842,285...869,753
Ensembl chr 9:842,288...869,716

G

SH3 and multiple ankyrin repeat domains 3

multiple interactions

[carbendazim co-treated with 2,5-hexanedione] affects the expression of SHANK3 mRNA

NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374

G

SIL1 nucleotide exchange factor

increases expression

2,5-hexanedione results in increased expression of SIL1 mRNA

NCBI chr18:26,872,423...27,104,365
Ensembl chr18:26,872,429...27,104,332

G

solute carrier family 10, member 7

increases expression

2,5-hexanedione results in increased expression of SLC10A7 mRNA

NCBI chr19:29,183,143...29,407,470
Ensembl chr19:29,183,155...29,407,464

G

SAFB-like, transcription modulator

increases expression

2,5-hexanedione results in increased expression of SLTM mRNA

NCBI chr 8:71,215,995...71,261,821
Ensembl chr 8:71,216,612...71,261,825

G

superoxide dismutase 1

decreases expression

2,5-hexanedione results in decreased expression of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 3

increases expression

2,5-hexanedione results in increased expression of SOD3 mRNA

PMID:22952946 PMID:27466211

NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990

G

signal peptide peptidase like 3

increases expression

2,5-hexanedione results in increased expression of SPPL3 mRNA

NCBI chr12:41,515,635...41,600,079
Ensembl chr12:41,515,640...41,600,126

G

sepiapterin reductase

decreases expression

2,5-hexanedione results in decreased expression of SPR protein

NCBI chr 4:117,671,948...117,676,292
Ensembl chr 4:117,671,949...117,675,678

G

spectrin, alpha, non-erythrocytic 1

decreases expression

2,5-hexanedione results in decreased expression of SPTAN1 protein

NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046

G

stathmin 1

decreases expression

2,5-hexanedione results in decreased expression of STMN1 mRNA

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

G

spermatid perinuclear RNA binding protein

increases expression

2,5-hexanedione results in increased expression of STRBP mRNA

NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949

G

serine/threonine/tyrosine interacting-like 1

increases expression

2,5-hexanedione results in increased expression of STYXL1 mRNA

NCBI chr12:20,907,410...20,940,232
Ensembl chr12:20,907,435...20,939,752

G

transgelin

decreases expression

2,5-hexanedione results in decreased expression of TAGLN protein

NCBI chr 8:46,224,939...46,230,413
Ensembl chr 8:46,222,472...46,230,668

G

Tax1 binding protein 1

increases expression

2,5-hexanedione results in increased expression of TAX1BP1 mRNA

NCBI chr 4:81,821,991...81,877,906
Ensembl chr 4:81,821,989...81,879,100

G

TBC1 domain family, member 5

increases expression

2,5-hexanedione results in increased expression of TBC1D5 mRNA

NCBI chr 9:3,503,328...4,017,131
Ensembl chr 9:3,513,623...4,016,913

G

thimet oligopeptidase 1

increases expression

2,5-hexanedione results in increased expression of THOP1 protein

NCBI chr 7:8,632,911...8,645,339
Ensembl chr 7:8,632,916...8,645,275

G

transmembrane protein 192

increases expression

2,5-hexanedione results in increased expression of TMEM192 mRNA

NCBI chr16:24,740,166...24,760,994
Ensembl chr16:24,740,124...24,761,021

G

tumor necrosis factor

multiple interactions
increases expression

Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of TNF mRNA]

PMID:32522579 PMID:32860822

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

triosephosphate isomerase 1

increases expression

2,5-hexanedione results in increased expression of TPI1 mRNA; 2,5-hexanedione results in increased expression of TPI1 protein

PMID:19033394 PMID:22952946

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

ubiquitin-like modifier activating enzyme 1

increases expression

2,5-hexanedione results in increased expression of UBA1 protein

NCBI chr X:1,508,700...1,530,677
Ensembl chr X:1,508,666...1,530,636

G

ubinuclein 2

increases expression

2,5-hexanedione results in increased expression of UBN2 mRNA

NCBI chr 4:67,165,278...67,251,562
Ensembl chr 4:67,166,346...67,230,491

G

ubiquinol cytochrome c reductase core protein 2

decreases expression

2,5-hexanedione results in decreased expression of UQCRC2 mRNA

NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453

G

uroporphyrinogen decarboxylase

decreases expression

2,5-hexanedione results in decreased expression of UROD protein

NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808

G

valosin-containing protein

decreases expression

2,5-hexanedione results in decreased expression of VCP protein

NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571

G

vimentin

multiple interactions

2,5-hexanedione promotes the reaction [VIM protein binds to VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

X-linked inhibitor of apoptosis

decreases expression

2,5-hexanedione results in decreased expression of XIAP mRNA

NCBI chr X:120,890,537...120,938,413
Ensembl chr X:120,897,907...120,934,700

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

decreases expression

2,5-hexanedione results in decreased expression of YWHAB protein

NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105

G

zinc finger protein 169

decreases expression

2,5-hexanedione results in decreased expression of ZFP169 protein

NCBI chr17:16,139,204...16,167,242
Ensembl chr17:16,139,253...16,169,914

G

zinc finger protein 407

increases expression

2,5-hexanedione results in increased expression of ZFP407 mRNA

NCBI chr18:77,571,140...77,970,282
Ensembl chr18:77,571,204...77,974,129

hexanal

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acyl-CoA thioesterase 9

increases methylation

n-hexanal results in increased methylation of ACOT9 gene

NCBI chr X:40,073,197...40,123,573
Ensembl chr X:40,064,810...40,123,559

G

alcohol dehydrogenase 6 (class V)

affects expression

n-hexanal affects the expression of ADH6 mRNA

NCBI chr 2:226,903,208...226,934,564
Ensembl chr 2:226,903,250...226,934,534

G

autoimmune regulator

increases methylation

n-hexanal results in increased methylation of AIRE gene

NCBI chr20:10,636,058...10,651,060
Ensembl chr20:10,636,123...10,651,060

G

aldo-keto reductase family 1 member B1

affects reduction
increases reduction

AKR1B1 protein affects the reduction of n-hexanal; AKR1B1 protein affects the reduction of n-hexanal analog
AKR1B1 protein results in increased reduction of n-hexanal

PMID:9890881 PMID:11306073

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

aldo-keto reductase family 7, member A2

decreases response to substance

AKR7A5 protein results in decreased susceptibility to n-hexanal

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

aldehyde dehydrogenase 1 family, member A1

increases oxidation

ALDH1A1 protein results in increased oxidation of n-hexanal

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member A2

increases oxidation

ALDH1A2 protein results in increased oxidation of n-hexanal

NCBI chr 8:71,877,850...71,957,107
Ensembl chr 8:71,877,850...71,957,107

G

aldehyde dehydrogenase 2 family member

affects metabolic processing

ALDH2 protein polymorphism affects the metabolism of n-hexanal

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

G

aldehyde dehydrogenase 3 family, member A1

affects metabolic processing
decreases response to substance

ALDH3A1 protein affects the metabolism of n-hexanal
ALDH3A1 protein results in decreased susceptibility to n-hexanal

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

aldehyde dehydrogenase 3 family, member B1

affects binding
decreases response to substance

n-hexanal binds to ALDH3B1 protein
ALDH3B1 protein results in decreased susceptibility to n-hexanal

NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921

G

aldehyde dehydrogenase 7 family, member A1

decreases response to substance

ALDH7A1 protein results in decreased susceptibility to n-hexanal

NCBI chr18:50,003,242...50,042,193
Ensembl chr18:50,009,934...50,042,193

G

Beta-1,3-galactosyltransferase 4

decreases expression

n-hexanal results in decreased expression of B3GALT4 mRNA

NCBI chr20:4,936,089...4,937,664
Ensembl chr20:4,931,768...4,938,315

G

bone morphogenetic protein 10

increases methylation

n-hexanal results in increased methylation of BMP10 gene

NCBI chr 4:119,872,066...119,877,694
Ensembl chr 4:119,872,045...119,878,627

G

similar to human chromosome 9 open reading frame 57

decreases methylation

n-hexanal results in decreased methylation of C9ORF57 gene

NCBI chr 1:219,079,683...219,084,806
Ensembl chr 1:219,079,683...219,084,806

G

carbonic anhydrase 9

decreases expression

n-hexanal results in decreased expression of CA9 mRNA

NCBI chr 5:57,763,234...57,769,838
Ensembl chr 5:57,763,206...57,769,838

G

C-C motif chemokine ligand 12

affects expression

n-hexanal affects the expression of CCL12 mRNA

NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780

G

cyclin A1

increases methylation

n-hexanal results in increased methylation of CCNA1 gene

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin B1 interacting protein 1

increases methylation

n-hexanal results in increased methylation of CCNB1IP1 gene

NCBI chr15:24,014,905...24,031,357
Ensembl chr15:24,014,908...24,028,475

G

CCAAT/enhancer binding protein delta

affects expression

n-hexanal affects the expression of CEBPD mRNA

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

centrosomal protein 85

increases methylation

n-hexanal results in increased methylation of CEP85 gene

NCBI chr 5:146,356,571...146,404,155
Ensembl chr 5:146,356,576...146,404,060

G

chromodomain helicase DNA binding protein 3

increases methylation

n-hexanal results in increased methylation of CHD3 gene

NCBI chr10:54,063,629...54,090,030
Ensembl chr10:54,063,629...54,090,047

G

chromogranin A

increases expression

n-hexanal results in increased expression of CHGA mRNA

NCBI chr 6:121,696,051...121,707,399
Ensembl chr 6:121,696,051...121,707,398

G

cytochrome c oxidase copper chaperone COX17

increases methylation

n-hexanal results in increased methylation of COX17 gene

NCBI chr11:62,400,733...62,406,507

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

n-hexanal results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

DNA-damage-inducible transcript 4

affects expression

n-hexanal affects the expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

dehydrogenase/reductase 9

increases expression

n-hexanal results in increased expression of DHRS9 mRNA

NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241

G

dynein, axonemal, assembly factor 2

increases methylation

n-hexanal results in increased methylation of DNAAF2 gene

NCBI chr 6:87,661,101...87,670,267
Ensembl chr 6:87,660,821...87,670,199

G

H2B clustered histone 6

increases methylation

n-hexanal results in increased methylation of H2BC6 gene

NCBI chr17:41,520,775...41,521,238

G

heme oxygenase 1

decreases expression

n-hexanal results in decreased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hydroxysteroid (17-beta) dehydrogenase 11

increases methylation

n-hexanal results in increased methylation of HSD17B11 gene

NCBI chr14:5,693,304...5,743,157
Ensembl chr14:5,711,964...5,743,161

G

joining chain of multimeric IgA and IgM

increases methylation

n-hexanal results in increased methylation of JCHAIN gene

NCBI chr14:19,538,927...19,547,023
Ensembl chr14:19,538,952...19,546,298

G

potassium voltage-gated channel modifier subfamily F member 1

increases methylation

n-hexanal results in increased methylation of KCNF1 gene

NCBI chr 6:39,962,301...39,964,979
Ensembl chr 6:39,962,307...39,964,979

G

kinesin family member 7

increases methylation

n-hexanal results in increased methylation of KIF7 gene

NCBI chr 1:133,639,487...133,658,539
Ensembl chr 1:133,640,065...133,658,576

G

KLF transcription factor 2

affects expression

n-hexanal affects the expression of KLF2 mRNA

NCBI chr16:17,521,107...17,523,739
Ensembl chr16:17,514,552...17,523,944

G

LHFPL tetraspan subfamily member 3

increases methylation

n-hexanal results in increased methylation of LHFPL3 gene

G

leucine rich repeat containing 74A

increases methylation

n-hexanal results in increased methylation of LRRC74A gene

NCBI chr 6:106,386,276...106,417,112
Ensembl chr 6:106,386,347...106,416,193

G

mitofusin 1

increases methylation

n-hexanal results in increased methylation of MFN1 gene

NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640

G

microRNA 101a

decreases expression

n-hexanal results in decreased expression of MIR101A mRNA

NCBI chr 5:115,966,332...115,966,406
Ensembl chr 5:115,966,328...115,966,410

G

microRNA 1224

decreases expression

n-hexanal results in decreased expression of MIR1224 mRNA

NCBI chr11:80,306,902...80,306,986
Ensembl chr11:80,306,902...80,306,986

G

microRNA 1249

decreases expression

n-hexanal results in decreased expression of MIR1249 mRNA

NCBI chr 7:116,075,593...116,075,712
Ensembl chr 7:116,075,593...116,075,712

G

microRNA 128-1

increases methylation

n-hexanal results in increased methylation of MIR128-1 gene

NCBI chr13:39,699,449...39,699,530
Ensembl chr13:39,699,449...39,699,530

G

microRNA 1306

decreases expression

n-hexanal results in decreased expression of MIR1306 mRNA

NCBI chr11:82,709,651...82,709,723
Ensembl chr11:82,709,637...82,709,719

G

microRNA 132

increases expression

n-hexanal results in increased expression of MIR132 mRNA

NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796

G

microRNA 136

decreases expression

n-hexanal results in decreased expression of MIR136 mRNA

NCBI chr 6:128,549,096...128,549,177
Ensembl chr 6:128,549,096...128,549,177

G

microRNA 145

decreases expression

n-hexanal results in decreased expression of MIR145 mRNA

NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727

G

microRNA 153

decreases expression

n-hexanal results in decreased expression of MIR153 mRNA

NCBI chr 6:138,163,595...138,163,681
Ensembl chr 6:138,163,595...138,163,681

G

microRNA 181b-1

decreases expression

n-hexanal results in decreased expression of MIR181B1 mRNA

NCBI chr13:49,485,688...49,485,797
Ensembl chr13:49,485,688...49,485,797

G

microRNA 184

decreases expression

n-hexanal results in decreased expression of MIR184 mRNA

NCBI chr 8:90,343,134...90,343,210
Ensembl chr 8:90,343,134...90,343,210

G

microRNA 188

decreases expression

n-hexanal results in decreased expression of MIR188 mRNA

NCBI chr X:15,247,715...15,247,794
Ensembl chr X:15,247,715...15,247,794

G

microRNA 190

decreases expression

n-hexanal results in decreased expression of MIR190 mRNA

NCBI chr 8:67,850,987...67,851,071
Ensembl chr 8:67,850,987...67,851,071

G

microRNA 193a

decreases expression

n-hexanal results in decreased expression of MIR193A mRNA

NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454

G

microRNA 200a

decreases expression

n-hexanal results in decreased expression of MIR200A mRNA

NCBI chr 5:166,648,494...166,648,582

G

microRNA 217

decreases expression

n-hexanal results in decreased expression of MIR217 mRNA

NCBI chr14:102,531,505...102,531,609
Ensembl chr14:102,531,505...102,531,609

G

microRNA 221

decreases expression

n-hexanal results in decreased expression of MIR221 mRNA

NCBI chr X:3,429,465...3,429,573
Ensembl chr X:3,429,465...3,429,573

G

microRNA 224

decreases expression

n-hexanal results in decreased expression of MIR224 mRNA

NCBI chr X:150,065,088...150,065,169
Ensembl chr X:150,065,088...150,065,169

G

microRNA 299b

decreases expression

n-hexanal results in decreased expression of MIR299 mRNA

NCBI chr 6:128,723,635...128,723,752
Ensembl chr 6:128,723,635...128,723,752

G

microRNA 29b-2

decreases expression

n-hexanal results in decreased expression of MIR29B2 mRNA

NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456

G

microRNA 326

decreases expression

n-hexanal results in decreased expression of MIR326 mRNA

NCBI chr 1:153,854,029...153,854,123
Ensembl chr 1:153,854,029...153,854,123

G

microRNA 328b

decreases expression

n-hexanal results in decreased expression of MIR328B mRNA

NCBI chr14:43,663,068...43,663,185
Ensembl chr14:43,663,068...43,663,185

G

microRNA 337

decreases expression

n-hexanal results in decreased expression of MIR337 mRNA

NCBI chr 6:128,538,903...128,538,999
Ensembl chr 6:128,538,902...128,538,998

G

microRNA 3568

decreases expression

n-hexanal results in decreased expression of MIR3568 mRNA

NCBI chr10:10,661,344...10,661,444
Ensembl chr10:10,661,344...10,661,444

G

microRNA 3582

decreases expression

n-hexanal results in decreased expression of MIR3582 mRNA

NCBI chr18:1,885,063...1,885,180
Ensembl chr18:1,885,063...1,885,180

G

microRNA 3585

decreases expression

n-hexanal results in decreased expression of MIR3585 mRNA

NCBI chr X:146,662,031...146,662,148
Ensembl chr X:146,662,031...146,662,148

G

microRNA 3594

decreases expression

n-hexanal results in decreased expression of MIR3594 mRNA

NCBI chr10:105,347,412...105,347,476
Ensembl chr10:105,347,412...105,347,476

G

microRNA 381

decreases expression

n-hexanal results in decreased expression of MIR381 mRNA

NCBI chr 6:128,740,976...128,741,036

G

microRNA 411

decreases expression

n-hexanal results in decreased expression of MIR411 mRNA

NCBI chr 6:128,723,189...128,723,264
Ensembl chr 6:128,723,184...128,723,279

G

microRNA 425

decreases expression

n-hexanal results in decreased expression of MIR425 mRNA

NCBI chr 8:109,264,555...109,264,637
Ensembl chr 8:109,264,555...109,264,637

G

microRNA 431

decreases expression

n-hexanal results in decreased expression of MIR431 mRNA

NCBI chr 6:128,544,210...128,544,323
Ensembl chr 6:128,544,210...128,544,323

G

microRNA 433

decreases expression

n-hexanal results in decreased expression of MIR433 mRNA

NCBI chr 6:128,545,119...128,545,211
Ensembl chr 6:128,545,112...128,545,217

G

microRNA 541

decreases expression

n-hexanal results in decreased expression of MIR541 mRNA

NCBI chr 6:128,757,016...128,757,105
Ensembl chr 6:128,757,016...128,757,105

G

microRNA 6315

decreases expression

n-hexanal results in decreased expression of MIR6315 mRNA

NCBI chr 1:203,363,908...203,364,008
Ensembl chr 1:203,363,908...203,364,008

G

microRNA mir-6317-1

decreases expression

n-hexanal results in decreased expression of MIR6317-1 mRNA

NCBI chr 1:239,398,926...239,399,052
Ensembl chr 1:239,398,926...239,399,052

G

microRNA 6332

decreases expression

n-hexanal results in decreased expression of MIR6332 mRNA

NCBI chr 5:160,837,304...160,837,424
Ensembl chr 5:160,837,304...160,837,424

G

microRNA 664-2

decreases expression

n-hexanal results in decreased expression of MIR664-2 mRNA

NCBI chr13:96,793,099...96,793,157
Ensembl chr13:96,793,099...96,793,157

G

microRNA 9

decreases expression

n-hexanal results in decreased expression of MIR7B mRNA

NCBI chr 9:1,080,274...1,080,383
Ensembl chr 9:1,080,274...1,080,383

G

microRNA let7f-1

decreases expression

n-hexanal results in decreased expression of MIRLET7F-1 mRNA

NCBI chr17:16,114,130...16,114,226
Ensembl chr17:16,114,130...16,114,226

G

matrix metallopeptidase 9

increases secretion

n-hexanal results in increased secretion of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

mitochondrial ribosomal protein S18A

increases methylation

n-hexanal results in increased methylation of MRPS18A gene

NCBI chr 9:14,853,322...14,869,819
Ensembl chr 9:14,853,291...14,869,835

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

n-hexanal results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myelin transcription factor 1

increases methylation

n-hexanal results in increased methylation of MYT1 gene

NCBI chr 3:168,890,466...168,950,341
Ensembl chr 3:168,886,089...168,950,341

G

nuclear transcription factor, X-box binding-like 1

increases methylation

n-hexanal results in increased methylation of NFXL1 gene

NCBI chr14:35,626,086...35,667,505
Ensembl chr14:35,626,066...35,667,498

G

neuromedin B receptor

increases methylation

n-hexanal results in increased methylation of NMBR gene

NCBI chr 1:9,115,033...9,146,081
Ensembl chr 1:9,134,889...9,145,462

G

NUF2 component of NDC80 kinetochore complex

increases methylation

n-hexanal results in increased methylation of NUF2 gene

NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766

G

olfactory receptor family 10 subfamily Z member 1

increases methylation

n-hexanal results in increased methylation of OR10Z1 gene

NCBI chr13:86,281,535...86,282,476
Ensembl chr13:86,278,626...86,283,642

G

protocadherin alpha 10

increases methylation

n-hexanal results in increased methylation of PCDHA10 gene

Ensembl chr18:28,581,225...28,846,211

G

protocadherin alpha 9

increases methylation

n-hexanal results in increased methylation of PCDHA9 gene

Ensembl chr18:28,581,225...28,846,211

G

phosphodiesterase 4A

increases methylation

n-hexanal results in increased methylation of PDE4A gene

NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961

G

peroxisomal biogenesis factor 2

increases methylation

n-hexanal results in increased methylation of PEX2 gene

NCBI chr 2:96,050,380...96,072,928
Ensembl chr 2:96,045,958...96,073,404

G

phosphatase and actin regulator 1

increases methylation

n-hexanal results in increased methylation of PHACTR1 gene

NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831

G

phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha

increases methylation

n-hexanal results in increased methylation of PIK3C2A gene

NCBI chr 1:170,577,942...170,684,353
Ensembl chr 1:170,577,942...170,683,472

G

phospholipid phosphatase related 5

increases methylation

n-hexanal results in increased methylation of PLPPR5 gene

NCBI chr 2:205,525,466...205,737,892
Ensembl chr 2:205,458,176...205,717,599

G

protein kinase cAMP-activated catalytic subunit beta

increases methylation

n-hexanal results in increased methylation of PRKACB gene

NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198

G

regenerating family member 1 alpha

increases methylation

n-hexanal results in increased methylation of REG1A gene

NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570

G

small Cajal body-specific RNA 3

decreases expression

n-hexanal results in decreased expression of SCARNA3 mRNA

NCBI chr 6:99,222,432...99,222,521
Ensembl chr 6:99,222,432...99,222,521

G

solute carrier family 39 member 5

decreases expression

n-hexanal results in decreased expression of SLC39A5 mRNA

NCBI chr 7:822,873...830,865
Ensembl chr 7:824,818...830,242

G

STE20-like kinase

increases methylation

n-hexanal results in increased methylation of SLK gene

NCBI chr 1:246,473,712...246,529,643
Ensembl chr 1:246,473,712...246,526,530

G

synuclein alpha

increases methylation

n-hexanal results in increased methylation of SNCA gene

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

small nucleolar RNA, H/ACA box 58

decreases expression

n-hexanal results in decreased expression of SNORA58 mRNA

NCBI chr 6:107,080,945...107,081,020
Ensembl chr 6:107,080,945...107,081,020

G

serine peptidase inhibitor, Kazal type 4

increases methylation

n-hexanal results in increased methylation of SPINK4 gene

NCBI chr 5:56,043,936...56,064,841
Ensembl chr 5:55,981,624...56,064,795

G

sperm-tail PG-rich repeat containing 4

increases methylation

n-hexanal results in increased methylation of STPG4 gene

NCBI chr 6:7,108,827...7,158,519
Ensembl chr 6:7,108,869...7,151,390

G

tudor and KH domain containing

increases methylation

n-hexanal results in increased methylation of TDRKH gene

NCBI chr 2:182,049,175...182,071,516
Ensembl chr 2:182,049,215...182,070,755

G

THUMP domain containing 3

increases methylation

n-hexanal results in increased methylation of THUMPD3 gene

NCBI chr 4:146,185,422...146,209,802
Ensembl chr 4:146,185,503...146,211,246

G

tumor necrosis factor

increases expression

n-hexanal results in increased expression of TNF mRNA

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

decreases expression

n-hexanal results in decreased expression of TP53 mRNA

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tripartite motif-containing 27

increases methylation

n-hexanal results in increased methylation of TRIM27 gene

NCBI chr17:43,538,282...43,550,633
Ensembl chr17:43,538,285...43,550,643

G

UBX domain protein 4

increases methylation

n-hexanal results in increased methylation of UBXN4 gene

NCBI chr13:39,740,064...39,772,493
Ensembl chr13:39,740,107...39,772,491

G

WD repeat domain 75

increases methylation

n-hexanal results in increased methylation of WDR75 gene

NCBI chr 9:47,903,214...47,933,399
Ensembl chr 9:47,903,200...47,933,399

G

zinc finger homeobox 2

increases methylation

n-hexanal results in increased methylation of ZFHX2 gene

NCBI chr15:28,533,155...28,565,667
Ensembl chr15:28,533,156...28,565,128

hexane-1,6-diamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adhesion G protein-coupled receptor L3

increases abundance

ADGRL3 gene modified form results in increased abundance of 1,6-diaminohexane

NCBI chr14:26,336,320...27,104,060
Ensembl chr14:26,368,277...27,105,860

G

myeloperoxidase

multiple interactions

[1,6-diaminohexane binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; [1,6-diaminohexane binds to TEMPO] inhibits the reaction [MPO protein results in increased degradation of Hydrogen Peroxide]; [1,6-diaminohexane binds to TEMPO] inhibits the reaction [MPO protein results in increased oxidation of Nitric Oxide]; Heparin inhibits the reaction [[1,6-diaminohexane binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

scavenger receptor class A, member 5

increases abundance

SCARA5 gene modified form results in increased abundance of 1,6-diaminohexane

NCBI chr15:39,880,017...39,985,007
Ensembl chr15:39,880,035...39,983,373

monohexyl phthalate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

heat shock transcription factor 1

increases activity

mono-n-hexyl phthalate results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

peroxisome proliferator activated receptor alpha

affects binding

mono-n-hexyl phthalate binds to PPARA protein

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

affects binding

mono-n-hexyl phthalate binds to PPARB protein

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peroxisome proliferator-activated receptor gamma

affects binding

mono-n-hexyl phthalate binds to PPARG protein

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19917
role	19887
biological role	19885
aetiopathogenetic role	19259
neurotoxin	18246
hexane	466
1-iminohexane-2,3,4,5-tetrol	0
1-isothiocyanato-6-(methylsulfanyl)hexane	0
1-nitrohexane	0
2,3,5-trimethylhexane	0
2,4-dimethylhexane	0
2,5-hexanedione	229
2-hexanamine	0
3-hexanone	0
3-mercaptohexanol +	0
3-methoxy-3-methylhexane	0
5-iminohexane-1,2,3,4,6-pentol	0
7-(methylthio)heptanonitrile oxide	0
hexanal	108
hexane-1,6-diamine +	3
hexane-1,6-diol +	0
hexane-2,5-diol +	0
hexanol +	4
hexyl group	0
perfluorohexane	0
Path 2
Term	Annotations
CHEBI ontology	19917
subatomic particle	19915
composite particle	19915
hadron	19915
baryon	19915
nucleon	19915
atomic nucleus	19915
atom	19915
main group element atom	19855
main group molecular entity	19855
s-block molecular entity	19666
hydrogen molecular entity	19668
hydrides	19176
organic hydride	18697
organic fundamental parent	18715
hydrocarbon	18459
alkane	14625
hexane	466
1-iminohexane-2,3,4,5-tetrol	0
1-isothiocyanato-6-(methylsulfanyl)hexane	0
1-nitrohexane	0
2,3,5-trimethylhexane	0
2,4-dimethylhexane	0
2,5-hexanedione	229
2-hexanamine	0
3-hexanone	0
3-mercaptohexanol +	0
3-methoxy-3-methylhexane	0
5-iminohexane-1,2,3,4,6-pentol	0
7-(methylthio)heptanonitrile oxide	0
hexanal	108
hexane-1,6-diamine +	3
hexane-1,6-diol +	0
hexane-2,5-diol +	0
hexanol +	4
hexyl group	0
perfluorohexane	0

paths to the root