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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:strychnine
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Accession:CHEBI:28973 term browser browse the term
Definition:A monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position.
Synonyms:exact_synonym: strychnidin-10-one
 related_synonym: Formula=C21H22N2O2;   InChI=1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1;   InChIKey=QMGVPVSNSZLJIA-FVWCLLPLSA-N;   SMILES=[H][C@@]12CC(=O)N3c4ccccc4[C@]45CCN6CC(=CCO1)[C@]([H])(C[C@@]46[H])[C@]2([H])[C@]35[H];   Strychnin
 alt_id: CHEBI:26795;   CHEBI:9293
 xref: BPDB:2066;   CAS:57-24-9;   Drug_Central:2484;   Gmelin:117894;   KEGG:C06522;   KNApSAcK:C00001770;   KNApSAcK:C00025213
 xref_mesh: MESH:D013331
 xref: PDBeChem:SY9;   PMID:10471592;   PMID:10821054;   PMID:11024105;   PMID:11157095;   PMID:11324564;   PMID:11327524;   PMID:11453337;   PMID:11516560;   PMID:11900860;   PMID:12611967;   PMID:12718443;   PMID:12742643;   PMID:12757728;   PMID:14530208;   PMID:14552874;   PMID:14575889;   PMID:15046720;   PMID:15275654;   PMID:15302677;   PMID:15601738;   PMID:15610168;   PMID:16075189;   PMID:16171972;   PMID:16887371;   PMID:16950410;   PMID:17145135;   PMID:17365101;   PMID:17449162;   PMID:17595105;   PMID:17827655;   PMID:17900376;   PMID:18199816;   PMID:19071748;   PMID:19194159;   PMID:19200346;   PMID:19394327;   PMID:19445923;   PMID:19617896;   PMID:19628662;   PMID:20534469;   PMID:20810461;   PMID:20837125;   PMID:21042643;   PMID:21109870;   PMID:21468359;   PMID:21506420;   PMID:21532268;   PMID:21616062;   PMID:21618309;   PMID:21666516;   PMID:21726589;   PMID:22168233;   PMID:22417832;   PMID:23395890;   PMID:25702781;   PMID:25877308;   PMID:25958869;   PMID:26028680;   PMID:26173662;   PMID:26223366;   PMID:26330182;   PMID:26416729;   PMID:26556179;   PMID:26625339;   PMID:9918589;   Reaxys:52979;   Wikipedia:Strychnine
 cyclic_relationship: is_conjugate_base_of CHEBI:90700


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strychnine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression EXP Strychnine results in increased expression of CASP3 mRNA CTD PMID:19815060 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 affects binding
multiple interactions		 ISO Strychnine binds to CHRM2 protein
Strychnine promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]		 CTD PMID:9495826 PMID:15647330 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding EXP
ISO		 Strychnine binds to CHRM3 protein CTD PMID:12435818 PMID:15647330 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 multiple interactions ISO Strychnine promotes the reaction [N-Methylscopolamine binds to CHRM4 protein] CTD PMID:9495826 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Strychnine results in increased expression of and results in increased degradation of CYP2B1 protein CTD PMID:7906730 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Strychnine results in increased expression of CYP2B2 protein CTD PMID:7906730 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP [Strychnine co-treated with Ketoconazole] results in decreased expression of CYP3A23-3A1 protein; [Strychnine co-treated with Phenobarbital] results in increased expression of CYP3A23-3A1 mRNA CTD PMID:35358606 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Strychnine results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions
decreases activity		 ISO
EXP		 Strychnine analog binds to and results in decreased activity of GLRA1 protein; Strychnine binds to and results in decreased activity of GLRA1 protein; Strychnine promotes the reaction [Genistein results in decreased activity of GLRA1 protein]; Strychnine promotes the reaction [Quercetin results in decreased activity of GLRA1 protein]
Genistein promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]; Quercetin promotes the reaction [Strychnine results in decreased activity of GLRA1 protein]		 CTD PMID:7752562 PMID:15081878 PMID:16687139 PMID:20719748 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162 		JBrowse link
G Glra2 glycine receptor, alpha 2 decreases activity EXP Strychnine results in decreased activity of GLRA2 protein CTD PMID:7752562 NCBI chr  X:29,020,377...29,241,666
Ensembl chr  X:29,020,557...29,241,666 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Strychnine inhibits the reaction [NAD inhibits the reaction [3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate results in increased secretion of IL1B protein]] CTD PMID:29642561 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Strychnine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 multiple interactions ISO Strychnine binds to and results in decreased activity of SCN5A protein CTD PMID:21616062 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Strychnine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19898
    role 19868
      application 19714
        pesticide 18084
          rodenticide 12373
            strychnine 14
              2-hydroxy-3-methoxystrychnine 0
              alpha-colubrine 0
              beta-colubrine 0
              pseudostrychnine 0
              strychnine N-oxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19898
    subatomic particle 19896
      composite particle 19896
        hadron 19896
          baryon 19896
            nucleon 19896
              atomic nucleus 19896
                atom 19896
                  main group element atom 19835
                    p-block element atom 19835
                      carbon group element atom 19774
                        carbon atom 19771
                          organic molecular entity 19771
                            heteroorganic entity 19528
                              organonitrogen compound 18853
                                alkaloid 8020
                                  indole alkaloid 1980
                                    terpenoid indole alkaloid 1501
                                      monoterpenoid indole alkaloid 1483
                                        strychnidine 14
                                          strychnine 14
                                            2-hydroxy-3-methoxystrychnine 0
                                            alpha-colubrine 0
                                            beta-colubrine 0
                                            pseudostrychnine 0
                                            strychnine N-oxide 0
paths to the root