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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-methoxy-17beta-estradiol
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Accession:CHEBI:28955 term browser browse the term
Definition:A 17beta-hydroxy steroid, being 17beta-estradiol methoxylated at C-2.
Synonyms:exact_synonym: 2-methoxyestra-1,3,5(10)-triene-3,17beta-diol
 related_synonym: 1,3,5(10)-ESTRATRIEN-2,3,17-BETA-TRIOL 2-METHYL ETHER;   2-Hydroxyestradol 2-methyl ether;   2-Methoxyestradiol-17beta;   2-methoxyestradiol;   Formula=C19H26O3;   InChI=1S/C19H26O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,18,20-21H,3-8H2,1-2H3/t12-,13+,15-,18-,19-/m0/s1;   InChIKey=CQOQDQWUFQDJMK-SSTWWWIQSA-N;   Panzem;   SMILES=[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc1cc(O)c(OC)cc21
 alt_id: CHEBI:1187;   CHEBI:19675;   CHEBI:42274
 xref: CAS:362-07-2;   KEGG:C05302;   LIPID_MAPS_instance:LMST02010035
 xref_mesh: MESH:C022830
 xref: PMID:12543804;   PMID:16828472;   PMID:16969706;   PMID:18566218;   PMID:19228747;   PMID:19577796;   PMID:20499131;   PMID:20960192;   PMID:9018099;   Patent:CA2499254;   Patent:CN1672746;   Patent:JP2005270658;   Patent:US2009104246;   Reaxys:3147966


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2-methoxy-17beta-estradiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO 2-Methoxyestradiol inhibits the reaction [Quercetin results in decreased phosphorylation of AKT1 protein]; [Quercetin co-treated with 2-Methoxyestradiol] results in decreased phosphorylation of AKT1 protein; Quercetin inhibits the reaction [2-Methoxyestradiol results in decreased phosphorylation of AKT1 protein] CTD PMID:26011145 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Aqp1 aquaporin 1 affects expression EXP 2-Methoxyestradiol affects the expression of AQP1 protein CTD PMID:21092735 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Aqp4 aquaporin 4 affects expression EXP 2-Methoxyestradiol affects the expression of AQP4 protein CTD PMID:21092735 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation ISO 2-Methoxyestradiol results in decreased phosphorylation of BAD protein CTD PMID:23967052 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO 2-Methoxyestradiol results in increased expression of BAK1 protein CTD PMID:36414027 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in decreased expression of BAX mRNA]
2-Methoxyestradiol results in increased expression of BAX protein		 CTD PMID:30154949 PMID:36414027 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
increases phosphorylation		 EXP
ISO		 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased expression of BCL2 mRNA]
2-Methoxyestradiol results in decreased expression of BCL2 protein
2-Methoxyestradiol results in increased phosphorylation of BCL2 protein		 CTD PMID:17418156 PMID:30154949 PMID:36414027 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO 2-Methoxyestradiol results in decreased expression of BCL2L1 protein CTD PMID:36414027 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 increases cleavage
increases expression
multiple interactions		 ISO 2-Methoxyestradiol results in increased cleavage of CASP3 protein
2-Methoxyestradiol results in increased expression of CASP3 protein modified form
2-Methoxyestradiol promotes the reaction [Quercetin results in increased cleavage of CASP3 protein]; Arsenic Trioxide promotes the reaction [2-Methoxyestradiol results in increased expression of CASP3 protein modified form]; Quercetin promotes the reaction [2-Methoxyestradiol results in increased cleavage of CASP3 protein]		 CTD PMID:23967052 PMID:26011145 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases expression
multiple interactions		 ISO 2-Methoxyestradiol results in increased expression of CASP7 protein modified form
Arsenic Trioxide promotes the reaction [2-Methoxyestradiol results in increased expression of CASP7 protein modified form]		 CTD PMID:23967052 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases expression ISO 2-Methoxyestradiol results in increased expression of CASP8 protein modified form CTD PMID:23967052 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases expression ISO 2-Methoxyestradiol results in increased expression of CASP9 protein modified form CTD PMID:23967052 PMID:36414027 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO 2-Methoxyestradiol results in decreased expression of CCNA2 protein CTD PMID:23967052 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions
increases expression		 ISO 2-Methoxyestradiol results in increased expression of and results in increased activity of CCNB1 protein
2-Methoxyestradiol results in increased expression of CCNB1 protein		 CTD PMID:16356831 PMID:23967052 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO 2-Methoxyestradiol results in decreased expression of CCND1 mRNA; 2-Methoxyestradiol results in decreased expression of CCND1 protein
[Ursolic Acid co-treated with 2-Methoxyestradiol] results in decreased expression of CCND1 mRNA		 CTD PMID:23967052 PMID:38044485 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO 2-Methoxyestradiol results in decreased expression of CCND3 protein CTD PMID:23967052 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371 		JBrowse link
G Ccne2 cyclin E2 decreases expression ISO 2-Methoxyestradiol results in decreased expression of CCNE2 protein CTD PMID:23967052 NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632 		JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO 2-Methoxyestradiol results in decreased expression of and affects the phosphorylation of CDC25C protein CTD PMID:23967052 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases phosphorylation ISO 2-Methoxyestradiol results in decreased phosphorylation of CDK1 protein CTD PMID:23967052 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO 2-Methoxyestradiol results in decreased expression of CDK2 protein CTD PMID:23967052 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO 2-Methoxyestradiol results in decreased expression of CDK4 protein CTD PMID:23967052 NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO 2-Methoxyestradiol results in increased expression of CDKN1B protein CTD PMID:23967052 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Comt catechol-O-methyltransferase affects chemical synthesis ISO COMT protein affects the chemical synthesis of 2-Methoxyestradiol CTD PMID:15377160 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions ISO 2-Methoxyestradiol inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein]; 2-Methoxyestradiol inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein] CTD PMID:16507596 NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO 2-Methoxyestradiol inhibits the reaction [CTNNB1 protein results in decreased susceptibility to Bortezomib]; [Ursolic Acid co-treated with 2-Methoxyestradiol] results in decreased expression of CTNNB1 mRNA
2-Methoxyestradiol results in decreased expression of CTNNB1 mRNA; 2-Methoxyestradiol results in decreased expression of CTNNB1 protein		 CTD PMID:18485479 PMID:38044485 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases abundance		 ISO Tetrachlorodibenzodioxin promotes the reaction [CYP1A1 protein results in increased abundance of 2-Methoxyestradiol]; Tetradecanoylphorbol Acetate inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [CYP1A1 protein results in increased abundance of 2-Methoxyestradiol]] CTD PMID:9706865 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Dnm1l dynamin 1-like increases expression ISO 2-Methoxyestradiol results in increased expression of DNM1L protein CTD PMID:36414027 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482 		JBrowse link
G Egf epidermal growth factor decreases expression ISO 2-Methoxyestradiol results in decreased expression of EGF mRNA; 2-Methoxyestradiol results in decreased expression of EGF protein CTD PMID:30779072 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO 2-Methoxyestradiol results in decreased expression of EGFR mRNA; 2-Methoxyestradiol results in decreased expression of EGFR protein CTD PMID:30779072 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Epo erythropoietin decreases expression
multiple interactions		 EXP 2-Methoxyestradiol results in decreased expression of EPO protein
2-Methoxyestradiol promotes the reaction [methylmercuric chloride results in decreased expression of EPO protein]; 2-Methoxyestradiol promotes the reaction [Methylmercury Compounds results in decreased expression of EPO protein]		 CTD PMID:31850806 PMID:32461003 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO 2-Methoxyestradiol results in increased expression of H2AX protein modified form CTD PMID:23967052 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression		 EXP
ISO		 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased expression of HIF1A protein]; 2-Methoxyestradiol promotes the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; 2-Methoxyestradiol promotes the reaction [Methylmercury Compounds results in decreased expression of HIF1A protein]
2-Methoxyestradiol inhibits the reaction [Glucose results in increased expression of HIF1A protein]
2-Methoxyestradiol results in decreased expression of HIF1A protein
2-Methoxyestradiol inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]		 CTD PMID:21617913 PMID:28624453 PMID:30154949 PMID:31850806 PMID:32461003 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 decreases response to substance
multiple interactions		 ISO HSD17B2 protein results in decreased susceptibility to 2-Methoxyestradiol
[HSD17B2 protein results in increased metabolism of and results in decreased activity of 2-Methoxyestradiol] which results in increased chemical synthesis of 2-methoxyestrone		 CTD PMID:16397246 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased expression of IL1A protein] CTD PMID:30154949 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased expression of IL1B protein] CTD PMID:30154949 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Mfn1 mitofusin 1 increases expression ISO 2-Methoxyestradiol results in increased expression of MFN1 protein CTD PMID:36414027 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640 		JBrowse link
G Nanog Nanog homeobox multiple interactions ISO 2-Methoxyestradiol inhibits the reaction [Curcumin results in increased expression of NANOG mRNA] CTD PMID:25822711 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase decreases expression ISO 2-Methoxyestradiol results in decreased expression of OPA1 protein CTD PMID:36414027 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO 2-Methoxyestradiol results in increased expression of PARP1 protein modified form CTD PMID:23967052 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO 2-Methoxyestradiol inhibits the reaction [Curcumin results in increased expression of POU5F1 mRNA] CTD PMID:25822711 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Prdx4 peroxiredoxin 4 increases expression ISO 2-Methoxyestradiol results in increased expression of PRDX4 protein CTD PMID:18272409 NCBI chr  X:40,026,762...40,044,066
Ensembl chr  X:40,026,651...40,044,066 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 2-Methoxyestradiol inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 mRNA]; 2-Methoxyestradiol inhibits the reaction [cobaltous chloride results in increased expression of PTGS2 protein] CTD PMID:28624453 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased expression of RELA protein] CTD PMID:30154949 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 decreases expression
multiple interactions		 EXP 2-Methoxyestradiol results in decreased expression of SLC2A1 protein
2-Methoxyestradiol promotes the reaction [methylmercuric chloride results in decreased expression of SLC2A1 protein]; 2-Methoxyestradiol promotes the reaction [Methylmercury Compounds results in decreased expression of SLC2A1 protein]		 CTD PMID:31850806 PMID:32461003 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions EXP 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased phosphorylation of SMAD2 protein] CTD PMID:30154949 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Sod2 superoxide dismutase 2 increases response to substance
multiple interactions
affects response to substance		 ISO SOD2 protein results in increased susceptibility to 2-Methoxyestradiol
2-Methoxyestradiol inhibits the reaction [Curcumin results in increased expression of SOD2 mRNA]
SOD2 protein affects the susceptibility to 2-Methoxyestradiol		 CTD PMID:17895890 PMID:22547077 PMID:25822711 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation
affects sulfation		 ISO SULT1A1 protein results in increased sulfation of 2-Methoxyestradiol
SULT1A1 gene polymorphism affects the sulfation of 2-Methoxyestradiol		 CTD PMID:16517757 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP 2-Methoxyestradiol inhibits the reaction [testosterone enanthate results in increased expression of TGFB1 protein] CTD PMID:30154949 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions
decreases expression		 ISO [Ursolic Acid co-treated with 2-Methoxyestradiol] results in decreased expression of TGFB3 mRNA
2-Methoxyestradiol results in decreased expression of TGFB3 mRNA		 CTD PMID:38044485 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO 2-Methoxyestradiol inhibits the reaction [Glucose results in decreased expression of TJP1 protein] CTD PMID:21617913 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tubb4a tubulin, beta 4A class IVa decreases expression ISO 2-Methoxyestradiol results in decreased expression of TUBB4A mRNA alternative form; 2-Methoxyestradiol results in decreased expression of TUBB4A protein alternative form CTD PMID:15924336 NCBI chr 9:1,917,841...1,925,286
Ensembl chr 9:1,917,845...1,925,291 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of 2-Methoxyestradiol CTD PMID:15117964 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 2-Methoxyestradiol CTD PMID:15117964 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of 2-Methoxyestradiol CTD PMID:15117964 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vegfa vascular endothelial growth factor A affects expression
multiple interactions
decreases expression		 EXP
ISO		 2-Methoxyestradiol affects the expression of VEGFA protein
2-Methoxyestradiol promotes the reaction [Quercetin results in decreased expression of VEGFA mRNA]; 2-Methoxyestradiol promotes the reaction [Quercetin results in decreased expression of VEGFA protein]; Quercetin promotes the reaction [2-Methoxyestradiol results in decreased expression of VEGFA mRNA]; Quercetin promotes the reaction [2-Methoxyestradiol results in decreased expression of VEGFA protein]
2-Methoxyestradiol inhibits the reaction [Glucose results in increased expression of VEGFA protein]
2-Methoxyestradiol results in decreased expression of VEGFA mRNA; 2-Methoxyestradiol results in decreased expression of VEGFA protein
2-Methoxyestradiol promotes the reaction [methylmercuric chloride results in decreased expression of VEGFA protein]; 2-Methoxyestradiol promotes the reaction [Methylmercury Compounds results in decreased expression of VEGFA protein]		 CTD PMID:21092735 PMID:21617913 PMID:26011145 PMID:31850806 PMID:32461003 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO 2-Methoxyestradiol results in decreased expression of XIAP protein CTD PMID:16356831 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19922
    role 19894
      biological role 19864
        biochemical role 19596
          metabolite 19558
            2-methoxy-17beta-estradiol 56
              2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19922
    subatomic particle 19892
      composite particle 19892
        hadron 19920
          baryon 19892
            nucleon 19920
              atomic nucleus 19892
                atom 19892
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19805
                        carbon atom 19802
                          organic molecular entity 19775
                            organic molecule 19755
                              organic cyclic compound 19545
                                organic polycyclic compound 17272
                                  steroid 14707
                                    hydroxy steroid 14456
                                      3-hydroxy steroid 12810
                                        phenolic steroid 11298
                                          estradiol 11305
                                            17beta-estradiol 11305
                                              2-methoxy-17beta-estradiol 56
                                                2-methoxy-17beta-estradiol 3-O-(beta-D-glucuronide) 0
paths to the root