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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:gramine
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Accession:CHEBI:28948 term browser browse the term
Definition:An aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3.
Synonyms:exact_synonym: 1-(1H-indol-3-yl)-N,N-dimethylmethanamine
 related_synonym: (1H-indol-3-ylmethyl)dimethylamine;   3-(Dimethylaminomethyl)indole;   3-(N,N-Dimethylaminomethyl)indole;   3-[(Dimethylamino)methyl]indole;   Donaxin;   Donaxine;   Formula=C11H14N2;   Gramin;   InChI=1S/C11H14N2/c1-13(2)8-9-7-12-11-6-4-3-5-10(9)11/h3-7,12H,8H2,1-2H3;   InChIKey=OCDGBSUVYYVKQZ-UHFFFAOYSA-N;   Indol-3-ylmethyldimethylamine;   N,N-Dimethyl-1H-indole-3-methanamine;   SMILES=C1(=CNC2=C1C=CC=C2)CN(C)C;   beta-Dimethylaminomethylindole
 alt_id: CHEBI:24428;   CHEBI:5531
 xref: CAS:87-52-5;   HMDB:HMDB0035762;   KEGG:C08304;   KNApSAcK:C00001411;   LINCS:LSM-6572
 xref_mesh: MESH:C007884
 xref: MetaCyc:CPD-8915;   PMID:23700450;   PMID:24332729;   PMID:24979400;   PMID:25149234;   PMID:25281166;   PMID:26920698;   PMID:27037659;   PMID:27138201;   PMID:27157767;   PMID:27250087;   PMID:27280380;   PMID:27854190;   PMID:28004092;   Reaxys:140521
 cyclic_relationship: is_conjugate_base_of CHEBI:136516


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gramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor1 adiponectin receptor 1 multiple interactions ISO gramine binds to and results in increased activity of ADIPOR1 protein CTD PMID:23691032 NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases phosphorylation ISO gramine results in decreased phosphorylation of PPARA protein CTD PMID:23691032 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO gramine results in increased phosphorylation of PRKAA1 protein CTD PMID:23691032 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 increases phosphorylation ISO gramine results in increased phosphorylation of PRKAA2 protein CTD PMID:23691032 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19880
    role 19850
      biological role 19848
        antimicrobial agent 18250
          antiviral agent 11343
            gramine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19880
    subatomic particle 19878
      composite particle 19878
        hadron 19878
          baryon 19878
            nucleon 19878
              atomic nucleus 19878
                atom 19878
                  main group element atom 19817
                    p-block element atom 19817
                      carbon group element atom 19757
                        carbon atom 19754
                          organic molecular entity 19754
                            organic molecule 19706
                              organic cyclic compound 19495
                                organic heterocyclic compound 18874
                                  organic heteropolycyclic compound 18300
                                    organic heterobicyclic compound 17242
                                      benzopyrrole 9742
                                        indoles 9430
                                          aminoalkylindole 570
                                            gramine 4
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