flavanones - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	flavanones	go back to main search page
Accession:	CHEBI:28863	browse the term
Definition:	Members of the class of flavans with a 3,4-dihydro-2-aryl-2H-1-benzopyran-4-one skeleton and its substituted derivatives.
Synonyms:	related_synonym:	2,3-dihydroflavones; a flavanone
	alt_id:	CHEBI:13636; CHEBI:24038; CHEBI:24054
	xref_mesh:	MESH:D044950
	xref:	metacyc.compound:FLAVANONES; wikipedia.en:Flavanone
	chemrof_smiles:	c1c()c()c(C2Oc3c()c()c()c()c3C(=O)C2)c()c1
	chemrof_formula:	C15H2O2R10

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Rat (597 ) Mouse (597 ) Human (612 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (1 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (597)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATM serine/threonine kinase

increases phosphorylation

ISO

Flavanones results in increased phosphorylation of ATM protein

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATR serine/threonine kinase

decreases phosphorylation

ISO

Flavanones results in decreased phosphorylation of ATR protein

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

Flavanones results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

ISO

Flavanones results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 2

increases cleavage
multiple interactions

ISO

Flavanones results in increased cleavage of CASP2 protein
U 0126 promotes the reaction [Flavanones results in increased cleavage of CASP2 protein]

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

increases cleavage

ISO

Flavanones results in increased cleavage of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

multiple interactions
increases cleavage

ISO

2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one promotes the reaction [Flavanones results in increased cleavage of CASP7 protein]; CDKN1A gene mutant form promotes the reaction [Flavanones results in increased cleavage of CASP7 protein]; PI103 promotes the reaction [Flavanones results in increased cleavage of CASP7 protein]; TP53 gene mutant form promotes the reaction [Flavanones results in increased cleavage of CASP7 protein]; U 0126 promotes the reaction [Flavanones results in increased cleavage of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

cyclin A1

decreases expression

ISO

Flavanones results in decreased expression of CCNA1 protein

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300

G

cyclin B1

decreases expression

ISO

Flavanones results in decreased expression of CCNB1 protein

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

decreases expression

ISO

Flavanones results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin E1

decreases expression

ISO

Flavanones results in decreased expression of CCNE1 protein

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression
decreases response to substance

ISO

CDKN1A gene mutant form promotes the reaction [Flavanones results in increased cleavage of CASP7 protein]; CDKN1A gene mutant form promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein]
Flavanones results in increased expression of CDKN1A protein
CDKN1A protein results in decreased susceptibility to Flavanones

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

checkpoint kinase 2

increases phosphorylation

ISO

Flavanones results in increased phosphorylation of CHEK2 protein

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

ISO

Flavanones results in decreased activity of CYP19A1 protein

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

H2A.X variant histone

multiple interactions
increases phosphorylation

ISO

2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein]; CDKN1A gene mutant form promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein]; PI103 promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein]; TP53 gene mutant form promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein]; U 0126 promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein]

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
decreases expression

ISO

Flavanones inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]
Flavanones results in decreased expression of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323

G

mitogen activated protein kinase 1

increases phosphorylation

ISO

Flavanones results in increased phosphorylation of MAPK1 protein

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

increases phosphorylation

ISO

Flavanones results in increased phosphorylation of MAPK3 protein

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

MDM2 proto-oncogene

increases phosphorylation

ISO

Flavanones results in increased phosphorylation of MDM2 protein

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

mechanistic target of rapamycin kinase

multiple interactions
decreases phosphorylation

ISO

Flavanones inhibits the reaction [cobaltous chloride results in increased phosphorylation of MTOR protein]
Flavanones results in decreased phosphorylation of MTOR protein

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

ISO

3-methyladenine promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]; bafilomycin A1 promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]; benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Flavanones results in increased cleavage of PARP1 protein]; U 0126 promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

ribosomal protein S6 kinase B1

multiple interactions
decreases phosphorylation

ISO

Flavanones inhibits the reaction [cobaltous chloride results in increased phosphorylation of RPS6KB1 protein]
Flavanones results in decreased phosphorylation of RPS6KB1 protein

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

tumor protein p53

increases expression
decreases response to substance
multiple interactions

ISO

Flavanones results in increased expression of TP53 protein
TP53 protein results in decreased susceptibility to Flavanones
TP53 gene mutant form promotes the reaction [Flavanones results in increased cleavage of CASP7 protein]; TP53 gene mutant form promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

vascular endothelial growth factor A

multiple interactions
decreases expression

ISO

Flavanones inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein]
Flavanones results in decreased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

(+)-dihydromyricetin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

mitogen activated protein kinase 1

multiple interactions

EXP

ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

EXP

ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

platelet derived growth factor subunit B

multiple interactions

EXP

ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]; ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein]

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343

G

platelet derived growth factor receptor beta

multiple interactions

EXP

ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]

NCBI chr18:56,770,348...56,809,228
Ensembl chr18:56,770,348...56,809,233

G

phospholipase C, gamma 1

multiple interactions

EXP

ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein]

NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050

G

sphingosine kinase 1

decreases expression
decreases activity

ISO

ampelopsin results in decreased expression of SPHK1 protein
ampelopsin results in decreased activity of SPHK1 protein

NCBI chr10:102,257,413...102,263,086
Ensembl chr10:102,258,975...102,263,082

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

taxifolin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 1

multiple interactions
decreases activity

ISO

taxifolin inhibits the reaction [ABCC1 protein affects the export of S-(2,4-dinitrophenyl)glutathione]
taxifolin results in decreased activity of ABCC1 protein

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

acetylcholinesterase

multiple interactions

EXP

taxifolin inhibits the reaction [Rotenone results in decreased activity of ACHE protein]

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

adiponectin receptor 2

multiple interactions

ISO

taxifolin binds to and results in increased activity of ADIPOR2 protein

NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:154,172,567...154,231,666

G

alpha-fetoprotein

affects binding
multiple interactions

EXP

taxifolin binds to AFP protein
alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of AFP protein]]

PMID:23013281 PMID:25349334 PMID:33840231

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

angiotensinogen

decreases expression

ISO

taxifolin results in decreased expression of AGT protein modified form

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

aryl hydrocarbon receptor

multiple interactions

ISO

AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA]; AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

AKT serine/threonine kinase 1

multiple interactions

EXP

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein]; taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]]

PMID:32828744 PMID:35465754

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

apolipoprotein A1

increases expression

ISO

taxifolin results in increased expression of APOA1 protein

NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729

G

apolipoprotein B

decreases secretion
decreases expression

ISO

taxifolin results in decreased secretion of APOB protein
taxifolin results in decreased expression of APOB protein

PMID:11108730 PMID:15380446

NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814

G

BCL2 associated X, apoptosis regulator

multiple interactions

EXP

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of BAX protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of BAX protein]]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

EXP

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of BCL2 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein]]

PMID:32525071 PMID:35465754

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

beclin 1

multiple interactions

EXP

alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of BECN1 protein]]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of BECN1 protein]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]; taxifolin inhibits the reaction [Colistin results in increased expression of BECN1 protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of BECN1 protein]]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of BECN1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of BECN1 protein]]

PMID:33840231 PMID:33882723 PMID:35465754

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

caspase 3

decreases activity
multiple interactions

EXP

taxifolin results in decreased activity of CASP3 protein
alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of CASP3 protein]]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of CASP3 protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein]; taxifolin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]; taxifolin inhibits the reaction [Colistin results in increased activity of CASP3 protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of CASP3 protein]]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased activity of CASP3 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of CASP3 protein]]

PMID:24269735 PMID:32828744 PMID:33840231 PMID:33882723 PMID:35465754

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

decreases activity
multiple interactions

EXP

taxifolin results in decreased activity of CASP9 protein
alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of CASP9 protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of CASP9 protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of CASP9 protein]]

PMID:24269735 PMID:33840231

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
decreases activity

EXP
ISO

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]]; taxifolin analog inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; taxifolin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CAT mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT mRNA]; taxifolin inhibits the reaction [Rotenone results in decreased activity of CAT protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of CAT protein]]
taxifolin results in decreased activity of CAT protein
taxifolin inhibits the reaction [Hydrogen Peroxide results in increased activity of CAT protein]

PMID:30372826 PMID:32525071 PMID:33741339 PMID:35187747 PMID:35465754 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cyclin A1

decreases expression

ISO

taxifolin results in decreased expression of CCNA1 mRNA

NCBI chr 2:141,383,352...141,428,205
Ensembl chr 2:141,382,468...141,393,300

G

cell division cycle 25A

decreases expression

ISO

taxifolin results in decreased expression of CDC25A mRNA

NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188

G

carnitine palmitoyltransferase 1A

multiple interactions

EXP

taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

cytochrome c, somatic

affects localization
multiple interactions

EXP

taxifolin affects the localization of CYCS protein
[taxifolin co-treated with dapagliflozin] inhibits the reaction [Colistin results in increased expression of CYCS protein]; taxifolin inhibits the reaction [Colistin results in increased expression of CYCS protein]

PMID:24269735 PMID:33882723

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

EXP

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of CYP11A1 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CYP11A1 protein]

PMID:32525071 PMID:36198370

NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:67,270,556...67,330,196

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

ISO

taxifolin results in increased expression of CYP1A1 mRNA; taxifolin results in increased expression of CYP1A1 protein
AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of CYP1A1 mRNA]

PMID:22422552 PMID:29584932

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

ISO

taxifolin results in decreased expression of CYP2E1 mRNA

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

DCC netrin 1 receptor

increases expression

ISO

taxifolin results in increased expression of DCC mRNA

NCBI chr18:67,144,272...68,248,159
Ensembl chr18:67,149,179...68,247,541

G

epidermal growth factor

decreases expression

ISO

taxifolin results in decreased expression of EGF mRNA

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

fibroblast growth factor 18

decreases expression

ISO

taxifolin results in decreased expression of FGF18 mRNA

NCBI chr10:18,210,240...18,241,929
Ensembl chr10:18,210,512...18,240,933

G

fibroblast growth factor 3

decreases expression

ISO

taxifolin results in decreased expression of FGF3 mRNA

NCBI chr 1:209,430,457...209,434,832
Ensembl chr 1:209,430,457...209,434,832

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

EXP

taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein]

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

follicle stimulating hormone subunit beta

multiple interactions

EXP

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of FSHB protein]]

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

glucose-6-phosphate dehydrogenase

multiple interactions

EXP

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased activity of G6PD protein]]

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

growth arrest specific 6

increases expression

ISO

taxifolin results in increased expression of GAS6 mRNA

NCBI chr16:82,747,676...82,778,090
Ensembl chr16:82,747,345...82,778,088

G

growth differentiation factor 15

increases expression

ISO

taxifolin results in increased expression of GDF15 mRNA

NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,838,436...18,842,022

G

glutamate-ammonia ligase

multiple interactions

EXP

taxifolin inhibits the reaction [Rotenone results in decreased activity of GLUL protein]

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:68,576,067...68,585,520

G

glutamic--pyruvic transaminase

multiple interactions

EXP

alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of GPT protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of GPT protein]; taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of GPT protein]]

PMID:32828744 PMID:33840231

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

multiple interactions

EXP

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of GPX1 protein]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione-disulfide reductase

multiple interactions

EXP

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]; taxifolin inhibits the reaction [Colistin results in decreased expression of GSR protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of GSR protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]]

PMID:33882723 PMID:35465754

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase mu 1

increases expression

ISO

taxifolin results in increased expression of GSTM1 mRNA

NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:198,338,008...198,343,569

G

heme oxygenase 1

increases expression
multiple interactions
decreases expression

ISO
EXP

taxifolin results in increased expression of HMOX1 protein
Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HMOX1 protein]]
Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of HMOX1 protein]

PMID:16799064 PMID:31152760 PMID:35465754

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hydroxysteroid (17-beta) dehydrogenase 1

multiple interactions

EXP

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD17B1 protein]]

NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,510,011...86,512,210

G

hydroxysteroid (17-beta) dehydrogenase 3

multiple interactions

EXP

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of HSD17B3 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD17B3 protein]

PMID:32525071 PMID:36198370

NCBI chr17:1,032,958...1,064,283
Ensembl chr17:1,032,958...1,064,283

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions

EXP

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of HSD3B1 protein]]

PMID:35465754 PMID:36198370

NCBI chr 2:188,858,574...188,864,694

G

intercellular adhesion molecule 1

multiple interactions

ISO

taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]

PMID:12044887 PMID:19103272

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon gamma

multiple interactions

ISO

taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; taxifolin inhibits the reaction [IFNG protein results in increased expression of ICAM1 protein]; taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein]
taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of IFNG protein]

PMID:12044887 PMID:19103272 PMID:31152760

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

multiple interactions

EXP

taxifolin inhibits the reaction [Rotenone results in increased expression of IKBKG mRNA]

NCBI chr X:157,358,279...157,397,563
Ensembl chr X:157,367,639...157,392,757

G

interleukin 15

multiple interactions

EXP

taxifolin inhibits the reaction [Colistin results in increased expression of IL15 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of IL15 protein]]

NCBI chr19:42,536,160...42,611,349
Ensembl chr19:42,545,346...42,611,348

G

interleukin 18

multiple interactions

EXP

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of IL18 protein]]

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286

G

interleukin 1 alpha

multiple interactions

EXP

alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of IL1A protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of IL1A protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of IL1A protein]]

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions

EXP
ISO

taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL1B protein]; taxifolin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]
taxifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B protein]

PMID:32828744 PMID:35187747 PMID:38574953

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

EXP
ISO

taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]
taxifolin inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein]

PMID:32828744 PMID:38574953

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin-like 3

multiple interactions

EXP

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of INSL3 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSL3 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of INSL3 protein]

PMID:32525071 PMID:36198370

NCBI chr16:18,432,668...18,434,539

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

ISO

taxifolin results in decreased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

luteinizing hormone subunit beta

multiple interactions

EXP

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of LHB protein]]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

mitogen-activated protein kinase 8

multiple interactions

ISO
EXP

taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein]
taxifolin inhibits the reaction [Colistin results in increased activity of MAPK8 protein]

PMID:12044887 PMID:33882723

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

marker of proliferation Ki-67

multiple interactions

EXP

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of MKI67 protein]]

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

myeloperoxidase

multiple interactions

EXP

taxifolin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; taxifolin inhibits the reaction [Rotenone results in increased activity of MPO protein]

PMID:33741339 PMID:35187747

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mechanistic target of rapamycin kinase

multiple interactions

EXP

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]]; taxifolin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased phosphorylation of MTOR protein]]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

microsomal triglyceride transfer protein

decreases activity

ISO

taxifolin results in decreased activity of MTTP protein

NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:229,286,501...229,327,650

G

NFE2 like bZIP transcription factor 2

increases expression
multiple interactions
decreases expression

ISO
EXP

taxifolin results in increased expression of NFE2L2 protein
alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of NFE2L2 protein]]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of NFE2L2 protein]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]; taxifolin inhibits the reaction [Colistin results in decreased expression of NFE2L2 protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of NFE2L2 protein]]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of NFE2L2 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of NFE2L2 protein]]
taxifolin results in decreased expression of NFE2L2 protein
Chlorpyrifos inhibits the reaction [taxifolin results in decreased expression of NFE2L2 protein]

PMID:16799064 PMID:31152760 PMID:33840231 PMID:33882723 PMID:35465754

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions

EXP

taxifolin inhibits the reaction [Rotenone results in increased expression of NFKB1 mRNA]

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

nerve growth factor

multiple interactions

EXP

taxifolin inhibits the reaction [Colistin results in decreased expression of NGF protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of NGF protein]]

NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834

G

NLR family, pyrin domain containing 3

multiple interactions

EXP

Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]]; taxifolin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of NLRP3 protein]]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

NAD(P)H quinone dehydrogenase 1

increases activity
increases expression

ISO

taxifolin results in increased activity of NQO1 protein
taxifolin results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

O-GlcNAcase

multiple interactions

EXP

[taxifolin co-treated with dapagliflozin] inhibits the reaction [Colistin results in increased activity of OGA protein]; taxifolin inhibits the reaction [Colistin results in increased activity of OGA protein]

NCBI chr 1:254,547,311...254,589,596
Ensembl chr 1:254,547,311...254,582,855

G

proliferating cell nuclear antigen

multiple interactions

EXP

[taxifolin co-treated with [Iron-Dextran Complex results in increased abundance of Iron]] results in increased expression of PCNA protein

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

platelet derived growth factor subunit B

decreases expression

ISO

taxifolin results in decreased expression of PDGFB mRNA

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

multiple interactions

EXP

taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of PIK3CA protein]

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411

G

paraoxonase 1

multiple interactions

EXP

alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of PON1 protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of PON1 protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in decreased expression of PON1 protein]]

NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924

G

peroxisome proliferator activated receptor alpha

increases phosphorylation

ISO

taxifolin results in increased phosphorylation of PPARA protein

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

PPARG coactivator 1 alpha

multiple interactions

EXP

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of PPARGC1A protein]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

protein kinase AMP-activated catalytic subunit alpha 1

decreases phosphorylation

ISO

taxifolin results in decreased phosphorylation of PRKAA1 protein

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

protein kinase AMP-activated catalytic subunit alpha 2

decreases phosphorylation

ISO

taxifolin results in decreased phosphorylation of PRKAA2 protein

NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

taxifolin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RAS p21 protein activator 1

decreases expression

ISO

taxifolin results in decreased expression of RASA1 mRNA

NCBI chr 2:17,593,136...17,676,707
Ensembl chr 2:17,593,136...17,676,161

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP

[alogliptin co-treated with taxifolin] inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of RELA protein]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of RELA protein]; taxifolin inhibits the reaction [Colistin results in increased expression of RELA protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of RELA protein]]

PMID:33840231 PMID:33882723

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

scavenger receptor class B, member 1

multiple interactions

EXP

taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SCARB1 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SCARB1 protein]

NCBI chr12:36,957,302...37,023,982
Ensembl chr12:36,957,496...37,023,980

G

sirtuin 1

multiple interactions

EXP

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SIRT1 protein]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein]

PMID:32525071 PMID:36198370

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

superoxide dismutase 1

multiple interactions

EXP

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 mRNA]; taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 protein]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions

EXP

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD2 mRNA]; taxifolin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA]

PMID:32525071 PMID:36198370

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

SRY-box transcription factor 9

multiple interactions

EXP

taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOX9 mRNA]

NCBI chr10:98,305,744...98,311,250
Ensembl chr10:98,305,744...98,311,250

G

signal transducer and activator of transcription 1

multiple interactions

ISO

taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein]

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 3

multiple interactions

EXP

taxifolin inhibits the reaction [Colistin results in decreased expression of STAT3 protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of STAT3 protein]]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

transforming growth factor, beta 1

multiple interactions

EXP

alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of TGFB1 protein]]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of TGFB1 protein]; taxifolin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; taxifolin inhibits the reaction [Colistin results in increased expression of TGFB1 protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of TGFB1 protein]]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of TGFB1 protein]]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]]

PMID:33840231 PMID:33882723 PMID:35465754

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tyrosine hydroxylase

multiple interactions

EXP

taxifolin inhibits the reaction [Rotenone results in decreased activity of TH protein]

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

toll-like receptor 4

multiple interactions

EXP

alogliptin promotes the reaction [taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of TLR4 protein]]; taxifolin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of TLR4 protein]; taxifolin inhibits the reaction [Colistin results in increased expression of TLR4 protein]; taxifolin promotes the reaction [alogliptin inhibits the reaction [[Diethylnitrosamine co-treated with Carbon Tetrachloride] results in increased expression of TLR4 protein]]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of TLR4 protein]]

PMID:33840231 PMID:33882723

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions

ISO
EXP

taxifolin inhibits the reaction [Chlorpyrifos results in increased secretion of TNF protein]
taxifolin inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]; taxifolin inhibits the reaction [Colistin results in increased expression of TNF protein]; taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in increased expression of TNF protein]]

PMID:31152760 PMID:32828744 PMID:33882723

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

Tnf receptor-associated factor 3

increases expression

ISO

taxifolin results in increased expression of TRAF3 mRNA

NCBI chr 6:136,025,097...136,128,363
Ensembl chr 6:136,027,157...136,128,363

G

thioredoxin reductase 1

increases expression
decreases activity

ISO
EXP

taxifolin results in increased expression of TXNRD1 mRNA
taxifolin results in decreased activity of TXNRD1 protein modified form

PMID:16618767 PMID:17541156

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817

G

uncoupling protein 1

multiple interactions

EXP

taxifolin analog inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA]

NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420

G

UDP glucuronosyltransferase family 1 member A1

increases expression
multiple interactions

ISO

taxifolin results in increased expression of UGT1A1 mRNA
AHR gene mutant form inhibits the reaction [taxifolin results in increased expression of UGT1A1 mRNA]

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

xanthine dehydrogenase

multiple interactions

ISO
EXP

taxifolin inhibits the reaction [XDH protein results in increased chemical synthesis of Superoxides]
taxifolin inhibits the reaction [Rotenone results in increased activity of XDH protein]

PMID:19555678 PMID:35187747

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

G

XPA, DNA damage recognition and repair factor

increases expression

ISO

taxifolin results in increased expression of XPA mRNA

NCBI chr 5:65,227,281...65,275,784
Ensembl chr 5:65,227,281...65,272,425

G

X-ray repair cross complementing 4

increases expression

ISO

taxifolin results in increased expression of XRCC4 mRNA

NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:22,686,508...22,933,160

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression
multiple interactions

ISO

naringenin results in increased expression of ABCB1 mRNA
naringenin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; naringenin inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]]; naringenin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]

PMID:19148864 PMID:34217736

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 1

multiple interactions
increases activity

ISO

[Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Glutathione promotes the reaction [naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin results in increased activity of ABCC1 protein]; naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; naringenin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; naringenin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; naringenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]

PMID:11306701 PMID:12485947 PMID:16156793

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 4

multiple interactions

ISO

naringenin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]; naringenin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily C member 5

multiple interactions

ISO

naringenin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; naringenin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]

NCBI chr11:93,975,579...94,071,659
Ensembl chr11:93,978,274...94,071,655

G

actin alpha 2, smooth muscle

multiple interactions

EXP

naringenin inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

adhesion G protein-coupled receptor B1

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of ADGRB1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ADGRB1 mRNA
naringenin metabolite results in increased expression of ADGRB1 mRNA

NCBI chr 7:108,293,681...108,365,892
Ensembl chr 7:108,293,818...108,365,870

G

alpha-fetoprotein

affects binding

EXP

naringenin binds to AFP protein

PMID:23013281 PMID:25349334

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

aryl hydrocarbon receptor

increases activity
multiple interactions

ISO

naringenin results in increased activity of AHR protein
naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]

PMID:17869316 PMID:20450880

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

aldo-keto reductase family 1, member C1

multiple interactions

ISO

naringenin binds to and results in decreased activity of AKR1C1 protein

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247

G

aldo-keto reductase family 1, member C3

decreases activity

ISO

naringenin results in decreased activity of AKR1C3 protein

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438

G

AKT serine/threonine kinase 1

multiple interactions
decreases expression

ISO
EXP

naringenin inhibits the reaction [bisphenol A results in increased activity of AKT1 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]
naringenin results in decreased expression of AKT1 mRNA
naringenin inhibits the reaction [lead acetate results in decreased expression of AKT1 protein]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]

PMID:22692793 PMID:22709785 PMID:25866363 PMID:36807407 PMID:36819991

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

albumin

multiple interactions

ISO

naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in increased expression of ALB protein]; naringenin inhibits the reaction [tyloxapol results in decreased expression of ALB mRNA]

PMID:31063766 PMID:37076581

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

alkaline phosphatase, biomineralization associated

multiple interactions

ISO

[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein; fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

apoptotic peptidase activating factor 1

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of APAF1 mRNA; naringenin results in increased expression of APAF1 protein
[naringenin co-treated with bisphenol A] results in increased expression of APAF1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of APAF1 mRNA

PMID:27838343 PMID:36235125

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

amyloid beta precursor protein

multiple interactions

EXP

naringenin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species]

NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971

G

aquaporin 1

multiple interactions

ISO

naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein]

NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504

G

aquaporin 5

multiple interactions

ISO

naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein]

NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:132,601,059...132,605,062

G

Rho GDP dissociation inhibitor alpha

increases expression

ISO

naringenin results in increased expression of ARHGDIA mRNA; naringenin results in increased expression of ARHGDIA protein

NCBI chr10:106,352,858...106,356,347
Ensembl chr10:106,353,491...106,356,347

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

ISO

naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]

NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:185,680,683...185,745,546

G

ATM serine/threonine kinase

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of ATM mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATR serine/threonine kinase

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of ATR mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ATR mRNA

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718

G

beta-secretase 1

decreases activity

ISO

naringenin results in decreased activity of BACE1 protein

NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:55,038,823...55,064,918

G

BCL2-antagonist/killer 1

increases expression

ISO

naringenin results in increased expression of BAK1 protein

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974

G

BCL2 associated X, apoptosis regulator

multiple interactions
decreases expression

EXP
ISO

naringenin inhibits the reaction [Glucose results in increased expression of BAX mRNA]; naringenin inhibits the reaction [Glucose results in increased expression of BAX protein]
[naringenin metabolite co-treated with bisphenol A] results in increased expression of BAX mRNA; naringenin inhibits the reaction [Pyruvaldehyde results in increased expression of BAX protein]; naringenin inhibits the reaction [Tamoxifen results in decreased expression of BAX mRNA]; Tamoxifen promotes the reaction [naringenin results in decreased expression of BAX mRNA]

PMID:23192364 PMID:30153467 PMID:31254498 PMID:36235125

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

Bcl-2 binding component 3

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of BBC3 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BBC3 mRNA

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

butyrylcholinesterase

multiple interactions

ISO

naringenin inhibits the reaction [[Tritolyl Phosphates co-treated with NADP] results in decreased activity of BCHE protein]

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

BCL2, apoptosis regulator

multiple interactions
decreases expression
decreases response to substance

ISO
EXP

[naringenin co-treated with bisphenol A] results in increased expression of BCL2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BCL2 mRNA; ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate inhibits the reaction [BCL2 protein results in decreased susceptibility to naringenin]; naringenin inhibits the reaction [Pyruvaldehyde results in decreased expression of BCL2 protein]; naringenin promotes the reaction [Tamoxifen results in decreased expression of BCL2 mRNA]
naringenin results in decreased expression of BCL2 mRNA
naringenin inhibits the reaction [Glucose results in decreased expression of BCL2 mRNA]; naringenin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]

PMID:19124070 PMID:23192364 PMID:30153467 PMID:31254498 PMID:36235125

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

BCL2-related protein A1

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of BCL2A1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of BCL2A1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BCL2A1 mRNA

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890

G

Bcl2-like 1

decreases expression

ISO

naringenin results in decreased expression of BCL2L1 protein

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

brain-derived neurotrophic factor

multiple interactions
increases expression

EXP

naringenin inhibits the reaction [Paraquat results in decreased expression of BDNF mRNA]
naringenin results in increased expression of BDNF mRNA

NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657

G

baculoviral IAP repeat-containing 5

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of BIRC5 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BIRC5 mRNA
naringenin metabolite results in increased expression of BIRC5 mRNA

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155

G

BRCA1, DNA repair associated

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of BRCA1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BRCA1 mRNA

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,917,693...86,977,763

G

BRCA2, DNA repair associated

increases expression
multiple interactions

ISO

naringenin results in increased expression of BRCA2 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of BRCA2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BRCA2 mRNA

NCBI chr12:4,895,092...4,939,340
Ensembl chr12:4,895,447...4,936,194

G

BTG anti-proliferation factor 2

decreases expression
multiple interactions

ISO

naringenin metabolite results in decreased expression of BTG2 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of BTG2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of BTG2 mRNA

NCBI chr13:48,083,931...48,087,690
Ensembl chr13:48,083,931...48,087,690

G

caspase 2

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CASP2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CASP2 mRNA
naringenin results in increased expression of CASP2 mRNA

NCBI chr 4:72,116,265...72,134,023
Ensembl chr 4:72,116,246...72,134,022

G

caspase 3

increases activity
increases expression
multiple interactions

ISO
EXP

naringenin results in increased activity of CASP3 protein
naringenin results in increased expression of CASP3 mRNA
naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP3 protein]
naringenin results in increased expression of CASP3 protein modified form
naringenin inhibits the reaction [Glucose results in increased activity of CASP3 protein]; naringenin inhibits the reaction [Glucose results in increased expression of and results in increased cleavage of CASP3 protein]; naringenin inhibits the reaction [Glucose results in increased expression of CASP3 mRNA]; naringenin inhibits the reaction [methylmercuric chloride results in increased expression of CASP3 protein]; naringenin inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]

PMID:19124070 PMID:22692793 PMID:23192364 PMID:27838343 PMID:31254498 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

increases expression

ISO

naringenin results in increased expression of CASP7 protein modified form

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 9

increases activity
multiple interactions
increases expression

ISO
EXP

naringenin results in increased activity of CASP9 protein
[naringenin co-treated with bisphenol A] results in increased expression of CASP9 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CASP9 mRNA; naringenin inhibits the reaction [Pyruvaldehyde results in increased activity of CASP9 protein]
naringenin metabolite results in increased expression of CASP9 mRNA; naringenin results in increased expression of CASP9 mRNA; naringenin results in increased expression of CASP9 protein modified form
naringenin inhibits the reaction [Glucose results in increased expression of and results in increased cleavage of CASP9 protein]; naringenin inhibits the reaction [Glucose results in increased expression of CASP9 mRNA]

PMID:19124070 PMID:23192364 PMID:27838343 PMID:31254498 PMID:36235125

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
decreases expression
increases activity

EXP
ISO

naringenin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; naringenin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]; naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of CAT protein]; naringenin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; naringenin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; naringenin inhibits the reaction [Glucose results in decreased activity of CAT protein]; naringenin inhibits the reaction [lead acetate results in decreased activity of CAT protein]; naringenin inhibits the reaction [Paraquat results in increased activity of CAT protein]; naringenin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
naringenin inhibits the reaction [Trichloroethylene results in decreased activity of CAT protein]
naringenin results in decreased expression of CAT protein
naringenin analog results in increased activity of CAT protein; naringenin results in increased activity of CAT protein
naringenin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]

PMID:19063931 PMID:19409769 PMID:23192364 PMID:23283742 PMID:23845967 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cyclin B1

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of CCNB1 mRNA

NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:33,646,252...33,655,225

G

cyclin D1

multiple interactions
decreases expression

ISO

[Tamoxifen co-treated with naringenin] results in decreased expression of CCND1 mRNA
naringenin results in decreased expression of CCND1 mRNA

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin E1

decreases expression
multiple interactions

ISO

naringenin results in decreased expression of CCNE1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of CCNE1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CCNE1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of CCNE1 mRNA

PMID:30153467 PMID:36235125

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cyclin G1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in decreased expression of CCNG1 mRNA

NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,677,885...25,683,766

G

cyclin H

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of CCNH mRNA

NCBI chr 2:17,570,449...17,591,078
Ensembl chr 2:17,570,263...17,614,860

G

cell division cycle 25A

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CDC25A mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDC25A mRNA
naringenin metabolite results in increased expression of CDC25A mRNA

NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:118,742,426...118,761,188

G

cell division cycle 25C

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CDC25C mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDC25C mRNA

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,609,959...26,630,292

G

cyclin-dependent kinase 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in decreased expression of CDK1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDK1 mRNA

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,265,289...19,280,455

G

cyclin-dependent kinase 4

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CDK4 mRNA

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CDKN1A mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CDKN1A mRNA; [Tamoxifen co-treated with naringenin] results in increased expression of CDKN1A mRNA
naringenin metabolite results in increased expression of CDKN1A mRNA; naringenin results in increased expression of CDKN1A mRNA

PMID:30153467 PMID:36235125

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 2A

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CDKN2A mRNA

NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248

G

CF transmembrane conductance regulator

multiple interactions

ISO

naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; naringenin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein]

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

checkpoint kinase 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CHEK1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CHEK1 mRNA

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359

G

checkpoint kinase 2

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CHEK2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CHEK2 mRNA

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667

G

carnitine palmitoyltransferase 1A

multiple interactions

EXP

naringenin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

CASP2 and RIPK1 domain containing adaptor with death domain

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of CRADD mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of CRADD mRNA
naringenin results in increased expression of CRADD mRNA

NCBI chr 7:31,827,131...31,839,796
Ensembl chr 7:31,685,622...31,874,512

G

catenin beta 1

decreases expression
multiple interactions

EXP

naringenin results in decreased expression of CTNNB1 mRNA
naringenin inhibits the reaction [Paraquat results in decreased expression of CTNNB1 mRNA]

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin D

multiple interactions

ISO

[naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cytochrome c, somatic

multiple interactions
increases expression

EXP
ISO

naringenin inhibits the reaction [Glucose affects the localization of CYCS protein]
naringenin results in increased expression of CYCS protein

PMID:23192364 PMID:27838343

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
decreases activity

ISO
EXP

naringenin binds to and results in decreased activity of CYP19A1 protein
naringenin results in decreased activity of CYP19A1 protein

PMID:9435150 PMID:15319488 PMID:17895526 PMID:38403145

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity
increases expression

ISO
EXP

naringenin binds to and results in decreased activity of CYP1A1 protein; naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
naringenin results in decreased activity of CYP1A1 protein
naringenin results in increased expression of CYP1A1 mRNA
naringenin promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]

PMID:11454723 PMID:20930378 PMID:21053930 PMID:27444380

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

ISO

naringenin results in decreased activity of CYP1A2 protein

PMID:21053930 PMID:29753067

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
increases expression

ISO

naringenin binds to and results in decreased activity of CYP1B1 protein
naringenin results in increased expression of CYP1B1 mRNA

PMID:21053930 PMID:31621310

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

ISO

naringenin results in decreased activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity

ISO
EXP

naringenin results in decreased activity of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
increases expression

ISO

naringenin results in decreased activity of CYP3A4 protein
naringenin results in increased expression of CYP3A4 mRNA

PMID:19148864 PMID:21053930 PMID:29753067

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DNA methyltransferase 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of DNMT1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of DNMT1 mRNA

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

dopamine receptor D2

decreases expression
multiple interactions

EXP

naringenin results in decreased expression of DRD2 mRNA
naringenin inhibits the reaction [Paraquat results in decreased expression of DRD2 mRNA]

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339

G

E2F transcription factor 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of E2F1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of E2F1 mRNA

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563

G

E2F transcription factor 3

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of E2F3 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of E2F3 mRNA

NCBI chr17:34,810,355...34,887,725
Ensembl chr17:34,809,998...34,887,725

G

epidermal growth factor receptor

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of EGFR mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of EGFR mRNA; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR protein]

PMID:25866363 PMID:36235125

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

early growth response 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of EGR1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843

G

estrogen receptor 1

multiple interactions
increases expression
decreases expression
affects binding
increases activity

ISO
EXP

[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein; [naringenin co-treated with bisphenol A] results in increased expression of ESR1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of ESR1 mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA; [naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PSEN2 mRNA; [SB 203580 co-treated with naringenin] results in increased degradation of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 mRNA alternative form; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein; [Tamoxifen co-treated with naringenin] results in decreased expression of ESR1 protein alternative form; Fulvestrant inhibits the reaction [[naringenin binds to ESR1 protein] which results in increased activity of ALPL protein]; naringenin binds to and results in increased activity of ESR1 protein; naringenin inhibits the reaction [Cycloheximide results in decreased expression of ESR1 protein]; naringenin inhibits the reaction [Estradiol results in decreased expression of ESR1 protein]; naringenin promotes the reaction [ESR1 protein binds to ESR1 protein]; naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein
naringenin metabolite results in increased expression of ESR1 mRNA; naringenin results in increased expression of ESR1 mRNA
naringenin results in decreased expression of ESR1 mRNA; naringenin results in decreased expression of ESR1 mRNA alternative form; naringenin results in decreased expression of ESR1 protein alternative form
naringenin results in increased activity of ESR1 protein

PMID:9751507 PMID:10397250 PMID:10854714 PMID:12650720 PMID:15713566 More...

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

multiple interactions
increases expression
increases activity
affects binding

ISO
EXP

[Tamoxifen co-treated with naringenin] results in increased expression of ESR2 mRNA; [Tamoxifen co-treated with naringenin] results in increased expression of ESR2 protein; bisphenol A inhibits the reaction [naringenin metabolite results in increased expression of ESR2 mRNA]; bisphenol A inhibits the reaction [naringenin results in increased expression of ESR2 mRNA]; naringenin binds to and results in increased activity of ESR2 protein; naringenin inhibits the reaction [Estradiol binds to ESR2 protein]
naringenin metabolite results in increased expression of ESR2 mRNA; naringenin results in increased expression of ESR2 mRNA; naringenin results in increased expression of ESR2 protein
naringenin results in increased activity of ESR2 protein
naringenin binds to ESR2 protein

PMID:9751507 PMID:12224631 PMID:16118406 PMID:16566672 PMID:17716812 More...

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

Fas associated via death domain

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of FADD mRNA

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

Fas cell surface death receptor

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of FAS mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of FAS mRNA
naringenin metabolite results in increased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of FASLG mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of FASLG mRNA
naringenin metabolite results in increased expression of FASLG mRNA

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

naringenin results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

forkhead box O3

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of FOXO3 mRNA

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

glucose-6-phosphate dehydrogenase

multiple interactions
decreases activity

EXP
ISO

[naringenin co-treated with lead acetate] results in decreased activity of G6PD protein; naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of G6PD protein]
naringenin results in decreased activity of G6PD protein

PMID:19063931 PMID:25130191 PMID:25228019

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

growth arrest and DNA-damage-inducible, alpha

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of GADD45A mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of GADD45A mRNA
naringenin metabolite results in increased expression of GADD45A mRNA

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

ISO

NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLC protein]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

increases expression
multiple interactions

ISO

naringenin results in increased expression of GCLM protein
NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLM protein]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glycosylphosphatidylinositol anchored molecule like

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of GML mRNA
[naringenin co-treated with bisphenol A] results in increased expression of GML mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of GML mRNA

NCBI chr 7:108,578,386...108,601,738

G

G protein-coupled estrogen receptor 1

multiple interactions
decreases expression

ISO

[Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 mRNA; [Tamoxifen co-treated with naringenin] results in decreased expression of GPER1 protein
naringenin metabolite results in decreased expression of GPER1 mRNA; naringenin results in decreased expression of GPER1 mRNA; naringenin results in decreased expression of GPER1 protein

PMID:30153467 PMID:36235125

NCBI chr12:20,331,073...20,336,527
Ensembl chr12:20,327,679...20,337,144

G

glutamic--pyruvic transaminase

multiple interactions

EXP

[naringenin co-treated with methylmercuric chloride] results in decreased activity of GPT protein; naringenin inhibits the reaction [Arsenic Trioxide results in increased activity of GPT protein]; naringenin inhibits the reaction [Streptozocin results in increased activity of GPT protein]

PMID:23283742 PMID:29223569 PMID:38308452

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

multiple interactions
decreases expression

EXP
ISO

naringenin inhibits the reaction [Glucose results in decreased expression of GPX1 mRNA]
naringenin results in decreased expression of GPX1 protein

PMID:23192364 PMID:28395574

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione peroxidase 2

multiple interactions
increases expression

ISO

[Paraquat co-treated with naringenin] results in increased expression of GPX2 mRNA
naringenin results in increased expression of GPX2 mRNA

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:101,226,745...101,230,862

G

glutathione peroxidase 3

multiple interactions

ISO

[Paraquat co-treated with naringenin] results in increased expression of GPX3 mRNA

NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,529,448...39,537,405

G

glutathione peroxidase 5

increases expression
multiple interactions

ISO

naringenin results in increased expression of GPX5 mRNA
[Paraquat co-treated with naringenin] results in increased expression of GPX5 mRNA

NCBI chr17:48,131,853...48,138,801
Ensembl chr17:48,093,895...48,138,801

G

glutathione peroxidase 7

multiple interactions
increases expression

ISO

[Paraquat co-treated with naringenin] results in increased expression of GPX7 mRNA
naringenin results in increased expression of GPX7 mRNA

NCBI chr 5:128,373,881...128,381,866
Ensembl chr 5:128,372,875...128,381,725

G

glutathione-disulfide reductase

multiple interactions
increases expression

EXP
ISO

naringenin inhibits the reaction [Cadmium Chloride results in decreased expression of GSR protein]; naringenin inhibits the reaction [Glucose results in decreased expression of GSR mRNA]
Paraquat inhibits the reaction [naringenin results in increased expression of GSR mRNA]

PMID:19063931 PMID:23192364 PMID:24561720

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase zeta 1

multiple interactions
increases expression

ISO

Paraquat inhibits the reaction [naringenin results in increased expression of GSTZ1 mRNA]

NCBI chr 6:112,525,576...112,536,228
Ensembl chr 6:112,525,377...112,536,233

G

hepatitis A virus cellular receptor 1

multiple interactions

ISO

naringenin inhibits the reaction [Carbon Tetrachloride results in increased expression of HAVCR1 protein]

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

hexokinase 2

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of HK2 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of HK2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of HK2 mRNA

NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275

G

heme oxygenase 1

multiple interactions
increases expression

EXP
ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringenin results in increased expression of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of and results in decreased activity of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of HMOX1 mRNA]; naringenin results in increased expression of and results in increased activity of HMOX1 protein; wortmannin inhibits the reaction [naringenin results in increased expression of HMOX1 protein]
naringenin results in increased expression of HMOX1 mRNA; naringenin results in increased expression of HMOX1 protein
[Paraquat co-treated with naringenin] results in increased expression of HMOX1 mRNA
naringenin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]

PMID:15316927 PMID:22709785 PMID:24561720

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

insulin-like growth factor 1 receptor

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of IGF1R mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of IGF1R mRNA

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664

G

inhibitor of nuclear factor kappa B kinase subunit beta

increases expression

ISO

naringenin results in increased expression of IKBKB mRNA

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 1 beta

multiple interactions

EXP
ISO

naringenin inhibits the reaction [lead acetate results in increased expression of IL1B protein]
naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

PMID:36807407 PMID:37880698

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of IL6 mRNA
naringenin inhibits the reaction [tyloxapol results in increased expression of IL6 mRNA]
[naringenin co-treated with bisphenol A] results in increased expression of IL6 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of IL6 mRNA

PMID:36235125 PMID:37076581

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

integrin subunit alpha 4

multiple interactions

EXP

naringenin inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]; naringenin inhibits the reaction [ITGA4 protein results in increased expression of TEK protein]; naringenin inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]

NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:84,560,369...84,641,039

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
increases expression

ISO

naringenin metabolite results in decreased expression of JUN mRNA; naringenin results in decreased expression of JUN mRNA
naringenin results in increased expression of JUN mRNA

PMID:28395574 PMID:36235125

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

lysine acetyltransferase 2B

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of KAT2B mRNA
[naringenin co-treated with bisphenol A] results in increased expression of KAT2B mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of KAT2B mRNA

NCBI chr 9:6,799,101...6,903,616
Ensembl chr 9:6,799,145...6,903,616

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

ISO

Amiodarone promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; azimilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; dofetilide promotes the reaction [naringenin results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Amiodarone results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [azimilide results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [dofetilide results in decreased activity of KCNH2 protein]; naringenin promotes the reaction [Quinidine results in decreased activity of KCNH2 protein]; Quinidine promotes the reaction [naringenin results in decreased activity of KCNH2 protein]

NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421

G

kinase insert domain receptor

multiple interactions

EXP

naringenin inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]

NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,572,049...32,615,192

G

KRAS proto-oncogene, GTPase

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of KRAS mRNA

NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320

G

luteinizing hormone subunit beta

multiple interactions

EXP

naringenin inhibits the reaction [lead acetate results in decreased expression of LHB protein]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

lactoperoxidase

increases expression
multiple interactions

ISO

naringenin results in increased expression of LPO mRNA
Paraquat inhibits the reaction [naringenin results in increased expression of LPO mRNA]

NCBI chr10:73,104,170...73,124,683
Ensembl chr10:73,104,188...73,123,456

G

leucine rich repeat containing 27

increases expression

ISO

naringenin results in increased expression of LRRC27 mRNA; naringenin results in increased expression of LRRC27 protein

NCBI chr 1:203,433,463...203,464,683
Ensembl chr 1:203,434,355...203,464,676

G

leucine-rich repeat kinase 2

decreases expression
multiple interactions

EXP

naringenin results in decreased expression of LRRK2 mRNA
naringenin inhibits the reaction [Paraquat results in decreased expression of LRRK2 mRNA]

NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239

G

mitogen-activated protein kinase kinase kinase 5

increases expression

ISO

naringenin results in increased expression of MAP3K5 protein

NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:16,505,596...16,723,898

G

mitogen activated protein kinase 1

multiple interactions
decreases expression
decreases activity
decreases phosphorylation

EXP
ISO

naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
naringenin results in decreased expression of MAPK1 mRNA
naringenin results in decreased activity of MAPK1 protein
naringenin results in decreased phosphorylation of MAPK1 protein
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK1 protein]

PMID:20450880 PMID:22709785 PMID:25866363 PMID:27468969 PMID:30431227 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
decreases activity
decreases phosphorylation

EXP
ISO

naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
naringenin results in decreased activity of MAPK3 protein
naringenin results in decreased phosphorylation of MAPK3 protein
naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
naringenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of MAPK3 protein]

PMID:20450880 PMID:22709785 PMID:25866363 PMID:27468969 PMID:30431227

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

increases phosphorylation

ISO

naringenin results in increased phosphorylation of MAPK8 protein

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

increases phosphorylation

ISO

naringenin results in increased phosphorylation of MAPK9 protein

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of MCL1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MCL1 mRNA

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

midkine

multiple interactions

EXP

naringenin inhibits the reaction [MDK protein results in increased phosphorylation of RELA protein]

NCBI chr 3:98,356,789...98,358,960
Ensembl chr 3:98,356,789...98,358,743

G

MDM2 proto-oncogene

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of MDM2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MDM2 mRNA
naringenin metabolite results in increased expression of MDM2 mRNA

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:55,176,560...55,200,791

G

MDM4 regulator of p53

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of MDM4 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MDM4 mRNA

NCBI chr13:46,922,236...47,068,241
Ensembl chr13:46,958,298...47,026,372

G

microRNA 141

decreases expression

ISO

naringenin metabolite results in decreased expression of MIR141 mRNA

NCBI chr 4:159,209,525...159,209,618

G

microRNA 200c

multiple interactions

ISO

naringenin inhibits the reaction [bisphenol A results in increased expression of MIR200C mRNA]; naringenin metabolite inhibits the reaction [bisphenol A results in increased expression of MIR200C mRNA]

NCBI chr 4:159,209,965...159,210,033

G

mutL homolog 1

increases expression
multiple interactions

ISO

naringenin results in increased expression of MLH1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of MLH1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MLH1 mRNA

NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:120,065,900...120,112,011

G

matrix metallopeptidase 2

decreases expression
multiple interactions

ISO

naringenin results in decreased expression of MMP2 mRNA
naringenin results in decreased expression of and results in decreased activity of MMP2 protein

PMID:30153467 PMID:30431227

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

multiple interactions
decreases expression

ISO

naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased secretion of MMP9 protein]; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; naringenin results in decreased expression of and results in decreased activity of MMP9 protein
naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]
naringenin results in decreased expression of MMP9 mRNA

PMID:25866363 PMID:30153467 PMID:30431227 PMID:37880698

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

mutS homolog 2

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of MSH2 mRNA

NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:12,567,368...12,626,503

G

mechanistic target of rapamycin kinase

multiple interactions

EXP

naringenin inhibits the reaction [lead acetate results in decreased expression of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

myogenic differentiation 1

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of MYOD1 mRNA; naringenin results in increased expression of MYOD1 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of MYOD1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of MYOD1 mRNA

NCBI chr 1:106,021,161...106,023,871
Ensembl chr 1:106,021,161...106,023,871

G

Nanog homeobox

decreases expression

ISO

naringenin results in decreased expression of NANOG protein

NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:157,615,687...157,623,061

G

neurofibromin 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of NF1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of NF1 mRNA

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,804,266...65,034,946

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases activity
increases expression

ISO

[naringenin co-treated with Paraquat] results in increased expression of NFE2L2 protein; naringenin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLM protein]
naringenin results in increased activity of NFE2L2 protein
naringenin results in increased expression of NFE2L2 mRNA

PMID:24561720 PMID:31254498

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of NFKB1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of NFKB1 mRNA

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

multiple interactions

ISO

naringenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NFKB inhibitor like 1

increases expression

ISO

naringenin results in increased expression of NFKBIL1 mRNA; naringenin results in increased expression of NFKBIL1 protein

NCBI chr20:3,595,319...3,610,295
Ensembl chr20:3,595,284...3,610,294

G

NME/NM23 nucleoside diphosphate kinase 1

increases expression

ISO

naringenin results in increased expression of NME1 mRNA; naringenin results in increased expression of NME1 protein

NCBI chr10:79,403,939...79,426,620
Ensembl chr10:79,403,940...79,413,310

G

nitric oxide synthase 2

multiple interactions

ISO

Hemin promotes the reaction [naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; naringenin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; naringenin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:10188978 PMID:12512693 PMID:15316927 PMID:18274639

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

ISO

[Paraquat co-treated with naringenin] results in increased expression of NQO1 mRNA
naringenin results in increased expression of NQO1 mRNA; naringenin results in increased expression of NQO1 protein

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group I, member 2

increases activity

ISO

naringenin results in increased activity of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

poly (ADP-ribose) polymerase 1

increases cleavage
multiple interactions

ISO

naringenin results in increased cleavage of PARP1 protein
naringenin inhibits the reaction [Pyruvaldehyde results in increased cleavage of PARP1 protein]

PMID:27838343 PMID:31254498

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

proliferating cell nuclear antigen

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of PCNA mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PCNA mRNA

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

phosphogluconate dehydrogenase

decreases activity

ISO

naringenin results in decreased activity of PGD protein

NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:164,865,830...164,882,029

G

progesterone receptor

increases expression
multiple interactions

EXP
ISO

naringenin results in increased expression of PGR mRNA
[naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA

PMID:10397250 PMID:24586459

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

p53-induced death domain protein 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of PIDD1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PIDD1 mRNA

NCBI chr 1:205,966,392...205,972,359
Ensembl chr 1:205,966,392...205,971,600

G

paraoxonase 1

increases expression

ISO

naringenin results in increased expression of PON1 mRNA

NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924

G

peroxisome proliferator activated receptor alpha

multiple interactions

EXP
ISO

HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARA protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARA protein]
naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARA protein]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor delta

multiple interactions

ISO
EXP

naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARB protein]
HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARB protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARB protein]

NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707

G

peroxisome proliferator-activated receptor gamma

multiple interactions

EXP
ISO

HET0016 inhibits the reaction [naringenin inhibits the reaction [Glucose results in decreased expression of PPARG protein]]; naringenin inhibits the reaction [Glucose results in decreased expression of PPARG protein]; naringenin inhibits the reaction [Streptozocin results in decreased expression of PPARG mRNA]; naringenin inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]
naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in decreased expression of PPARG protein]

PMID:29223569 PMID:31063766

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

protein phosphatase, Mg2+/Mn2+ dependent, 1D

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of PPM1D mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PPM1D mRNA

NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,670,020...70,706,256

G

peroxiredoxin 1

decreases expression

ISO

naringenin results in decreased expression of PRDX1 mRNA; naringenin results in decreased expression of PRDX1 protein

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:135,383,906...135,399,504

G

protein kinase C, alpha

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of PRKCA mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of PRKCA mRNA; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]

PMID:25866363 PMID:36235125

NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572

G

protein kinase C, beta

multiple interactions

ISO

naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCB protein]

NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740

G

protein kinase C, gamma

multiple interactions

ISO

naringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCG protein]

NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:74,748,272...74,774,814

G

prominin 1

decreases expression

ISO

naringenin results in decreased expression of PROM1 protein

NCBI chr14:71,202,303...71,307,008
Ensembl chr14:71,202,336...71,307,002

G

presenilin 2

multiple interactions

ISO

[naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PSEN2 mRNA

NCBI chr13:94,499,451...94,528,419
Ensembl chr13:94,499,928...94,525,116

G

phosphatase and tensin homolog

multiple interactions
increases expression

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of PTEN mRNA
naringenin results in increased expression of PTEN mRNA

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin-endoperoxide synthase 1

increases expression

ISO

naringenin results in increased expression of PTGS1 mRNA

NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO
EXP

naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
naringenin inhibits the reaction [Trichloroethylene results in increased expression of PTGS2 protein]
naringenin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]

PMID:21341175 PMID:25855085 PMID:27206700

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

PTTG1 regulator of sister chromatid separation, securin

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of PTTG1 mRNA
[naringenin metabolite co-treated with bisphenol A] results in increased expression of PTTG1 mRNA

NCBI chr10:28,394,940...28,406,410
Ensembl chr10:28,394,814...28,406,309

G

RB transcriptional corepressor 1

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of RB1 mRNA

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO
EXP

naringenin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]
naringenin inhibits the reaction [Trichloroethylene results in increased expression of RELA protein]
naringenin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]; naringenin inhibits the reaction [MDK protein results in increased phosphorylation of RELA protein]

PMID:18274639 PMID:25855085 PMID:27206700 PMID:36731809

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

reprimo, TP53 dependent G2 arrest mediator homolog

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of RPRM mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of RPRM mRNA
naringenin metabolite results in increased expression of RPRM mRNA; naringenin results in increased expression of RPRM mRNA

NCBI chr 3:58,948,618...58,950,035
Ensembl chr 3:58,799,866...58,950,542

G

regulatory associated protein of MTOR, complex 1

increases expression

ISO

naringenin results in increased expression of RPTOR mRNA; naringenin results in increased expression of RPTOR protein

NCBI chr10:105,376,943...105,675,416
Ensembl chr10:105,376,943...105,675,413

G

serpin family E member 1

multiple interactions

EXP

naringenin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:25,237,952...25,248,357

G

sestrin 2

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of SESN2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of SESN2 mRNA

NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:149,986,317...150,005,255

G

sex hormone binding globulin

affects binding

ISO

naringenin binds to SHBG protein

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

G

sucrase-isomaltase

decreases activity
multiple interactions

EXP
ISO

naringenin results in decreased activity of SI protein
naringenin binds to and results in decreased activity of SI protein

NCBI chr 2:159,804,568...159,884,902
Ensembl chr 2:159,804,568...159,883,934

G

siah E3 ubiquitin protein ligase 1

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of SIAH1 mRNA

NCBI chr19:36,552,165...36,575,773
Ensembl chr19:36,540,947...36,581,541

G

sirtuin 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of SIRT1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of SIRT1 mRNA

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

solute carrier family 16 member 1

multiple interactions

ISO
EXP

naringenin inhibits the reaction [SLC16A1 protein results in increased uptake of Benzoic Acid]
[naringenin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate

PMID:17108059 PMID:17976262

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

solute carrier family 2 member 1

multiple interactions
decreases activity

ISO

naringenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]
naringenin results in decreased activity of SLC2A1 protein

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742

G

solute carrier family 2 member 4

multiple interactions

EXP

naringenin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; naringenin inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier family 5 member 1

multiple interactions

ISO

naringenin inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside]

NCBI chr14:81,778,495...81,843,084
Ensembl chr14:81,778,348...81,846,624

G

solute carrier family 6 member 3

decreases expression
multiple interactions

EXP

naringenin results in decreased expression of SLC6A3 mRNA
naringenin inhibits the reaction [Paraquat results in decreased expression of SLC6A3 mRNA]

NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962

G

solute carrier organic anion transporter family member 1B2

multiple interactions

ISO

naringenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

snail family transcriptional repressor 1

decreases expression

ISO

naringenin results in decreased expression of SNAI1 protein

NCBI chr 3:176,667,476...176,671,965

G

snail family transcriptional repressor 2

decreases expression

ISO

naringenin results in decreased expression of SNAI2 protein

NCBI chr11:99,686,934...99,690,349
Ensembl chr11:99,686,934...99,690,349

G

synuclein alpha

multiple interactions
increases expression

EXP

naringenin inhibits the reaction [Paraquat results in increased expression of SNCA mRNA]
naringenin results in increased expression of SNCA mRNA

NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315

G

suppressor of cytokine signaling 3

increases expression

ISO

naringenin results in increased expression of SOCS3 mRNA

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825

G

superoxide dismutase 1

multiple interactions
decreases expression

EXP
ISO

naringenin inhibits the reaction [Glucose results in increased expression of SOD1 mRNA]
naringenin results in decreased expression of SOD1 protein

PMID:23192364 PMID:28395574

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

multiple interactions

EXP

naringenin inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

SRY-box transcription factor 2

decreases expression

ISO

naringenin results in decreased expression of SOX2 protein

NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:119,454,541...119,496,350

G

secreted phosphoprotein 1

multiple interactions

EXP

naringenin inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

signal transducer and activator of transcription 1

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in decreased expression of STAT1 mRNA

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 3

decreases phosphorylation

ISO

naringenin results in decreased phosphorylation of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

sulfotransferase family 1A member 1

multiple interactions

ISO
EXP

Mefenamic Acid inhibits the reaction [SULT1A1 protein results in increased sulfation of naringenin]

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

transcriptional adaptor 3

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in decreased expression of TADA3 mRNA

NCBI chr 4:148,065,859...148,077,347
Ensembl chr 4:148,065,877...148,077,320

G

TEK receptor tyrosine kinase

multiple interactions

EXP

naringenin inhibits the reaction [ITGA4 protein results in increased expression of TEK protein]

NCBI chr 5:114,722,815...114,849,535
Ensembl chr 5:114,723,006...114,849,991

G

transforming growth factor, beta 1

multiple interactions

ISO
EXP

naringenin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
naringenin inhibits the reaction [lead acetate results in increased expression of TGFB1 protein]

PMID:23845967 PMID:36807407

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tyrosine hydroxylase

multiple interactions
decreases expression

EXP

naringenin inhibits the reaction [Paraquat results in decreased expression of TH protein]
naringenin results in decreased expression of TH protein

NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227

G

tumor necrosis factor

multiple interactions
increases expression
decreases activity

ISO
EXP

[naringenin co-treated with bisphenol A] results in increased expression of TNF mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TNF mRNA; naringenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
naringenin metabolite results in increased expression of TNF mRNA
naringenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]; naringenin inhibits the reaction [tyloxapol results in increased expression of TNF mRNA]
naringenin results in decreased activity of TNF protein
naringenin inhibits the reaction [lead acetate results in increased expression of TNF protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of and results in decreased activity of HMOX1 protein]; naringenin inhibits the reaction [TNF protein results in decreased expression of HMOX1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased expression of SPP1 mRNA]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; naringenin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; zinc protoporphyrin inhibits the reaction [naringenin results in decreased activity of TNF protein]

PMID:18720166 PMID:19135038 PMID:22709785 PMID:36235125 PMID:36807407 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions
increases expression

ISO

[Tamoxifen co-treated with naringenin] results in increased expression of TP53 mRNA; naringenin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of TP53 protein]; naringenin results in increased expression of and results in increased phosphorylation of TP53 protein
naringenin results in increased expression of TP53 mRNA

PMID:15795422 PMID:27838343 PMID:30153467

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

tumor protein p53 binding protein, 2

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in increased expression of TP53BP2 mRNA

NCBI chr13:96,620,429...96,677,090
Ensembl chr13:96,620,428...96,677,616

G

tumor protein p63

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of TP63 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TP63 mRNA
naringenin metabolite results in increased expression of TP63 mRNA; naringenin results in increased expression of TP63 mRNA

NCBI chr11:88,343,647...88,554,543
Ensembl chr11:88,343,651...88,554,177

G

tumor protein p73

increases expression
multiple interactions

ISO

naringenin metabolite results in increased expression of TP73 mRNA; naringenin results in increased expression of TP73 mRNA
[naringenin co-treated with bisphenol A] results in increased expression of TP73 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TP73 mRNA

NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:169,903,801...169,963,552

G

thyroid peroxidase

decreases activity

EXP

naringenin results in decreased activity of TPO protein

NCBI chr 6:52,425,998...52,495,793
Ensembl chr 6:52,426,010...52,495,793

G

Tnf receptor-associated factor 2

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of TRAF2 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of TRAF2 mRNA

NCBI chr 3:28,740,098...28,764,752
Ensembl chr 3:28,740,098...28,764,691

G

TSC complex subunit 1

multiple interactions

ISO

[naringenin co-treated with bisphenol A] results in increased expression of TSC1 mRNA

NCBI chr 3:32,367,434...32,416,565
Ensembl chr 3:32,367,670...32,416,568

G

uncoupling protein 1

multiple interactions

EXP

naringenin inhibits the reaction [Dietary Fats results in decreased expression of UCP1 mRNA]

NCBI chr19:41,713,350...41,721,421
Ensembl chr19:41,713,351...41,721,420

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation
increases expression

ISO

UGT1A1 protein results in increased glucuronidation of naringenin
naringenin results in increased expression of UGT1A1 mRNA

PMID:14557274 PMID:31621310

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 1 member A9

increases glucuronidation

ISO

UGT1A9 protein results in increased glucuronidation of naringenin

PMID:14557274 PMID:18816295

NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264

G

UDP glucuronosyltransferase family 2 member B15

increases metabolic processing

EXP

UGT2B15 protein results in increased metabolism of naringenin

NCBI chr14:21,122,866...21,138,450
Ensembl chr14:21,122,861...21,138,467

G

vascular endothelial growth factor A

multiple interactions

ISO
EXP

naringenin inhibits the reaction [tyloxapol results in increased expression of VEGFA mRNA]
naringenin inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]

PMID:36731809 PMID:37076581

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

WT1 transcription factor

multiple interactions
increases expression

ISO

[naringenin co-treated with bisphenol A] results in increased expression of WT1 mRNA; [naringenin metabolite co-treated with bisphenol A] results in increased expression of WT1 mRNA
naringenin metabolite results in increased expression of WT1 mRNA

NCBI chr 3:112,019,721...112,068,454
Ensembl chr 3:112,021,641...112,068,444

G

xanthine dehydrogenase

multiple interactions

EXP

naringenin inhibits the reaction [Benzo(a)pyrene results in increased activity of XDH protein]

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

G

X-ray repair cross complementing 5

multiple interactions

ISO

[naringenin metabolite co-treated with bisphenol A] results in decreased expression of XRCC5 mRNA

NCBI chr 9:81,404,507...81,493,293
Ensembl chr 9:81,375,863...81,493,293

3'-hydroxyflavanone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-fetoprotein

affects binding

EXP

3-hydroxyflavanone binds to AFP protein

PMID:23013281 PMID:25349334

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

sex hormone binding globulin

affects binding

ISO

3-hydroxyflavanone binds to SHBG protein

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

4'-hydroxyflavanone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-fetoprotein

affects binding

EXP

4'-hydroxyflavanone binds to AFP protein

PMID:23013281 PMID:25349334

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

sex hormone binding globulin

affects binding

ISO

4'-hydroxyflavanone binds to SHBG protein

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

6-prenylnaringenin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression
multiple interactions

ISO

6-prenylnaringenin results in increased expression of CYP1A1 mRNA; 6-prenylnaringenin results in increased expression of CYP1A1 protein
6-prenylnaringenin inhibits the reaction [DNMT1 protein binds to CYP1A1 promoter]; 6-prenylnaringenin inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]]; 6-prenylnaringenin inhibits the reaction [Estradiol results in decreased expression of CYP1A1 mRNA]

PMID:27269377 PMID:32986415

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily b, polypeptide 1

increases expression

ISO

6-prenylnaringenin results in increased expression of CYP1B1 mRNA

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

DNA methyltransferase 1

multiple interactions

ISO

6-prenylnaringenin inhibits the reaction [DNMT1 protein binds to CYP1A1 promoter]; 6-prenylnaringenin inhibits the reaction [Estradiol promotes the reaction [DNMT1 protein binds to CYP1A1 promoter]]

NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119

G

estrogen receptor 1

multiple interactions
decreases expression

ISO

2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [6-prenylnaringenin results in decreased expression of ESR1 protein]; 6-prenylnaringenin promotes the reaction [Estradiol results in decreased expression of ESR1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [6-prenylnaringenin results in decreased expression of ESR1 protein]

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

7-hydroxyflavanone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-fetoprotein

affects binding

EXP

7-hydroxyflavanone binds to AFP protein

PMID:23013281 PMID:25349334

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

ISO

7-hydroxyflavanone results in decreased activity of CYP19A1 protein

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

sex hormone binding globulin

affects binding

ISO

7-hydroxyflavanone binds to SHBG protein

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1, member C1

multiple interactions

ISO

[astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247

G

AKT serine/threonine kinase 1

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

multiple interactions

ISO

astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

interleukin 1 beta

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

mitogen activated protein kinase 1

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein]
astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

poly (ADP-ribose) polymerase 1

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

tumor necrosis factor

multiple interactions

ISO

astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA]
astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adhesion G protein-coupled receptor E1

multiple interactions

ISO

[Lipopolysaccharides co-treated with bavachinin] results in increased expression of ADGRE1 protein; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Lipopolysaccharides co-treated with bavachinin] results in increased expression of ADGRE1 protein]

NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,329,438...2,484,959

G

absent in melanoma 2

multiple interactions

ISO

AIM2 protein affects the reaction [[Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased activity of and results in increased cleavage of CASP1 protein]; AIM2 protein affects the reaction [[Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased expression of IL1B protein]

NCBI chr13:88,397,516...88,439,325
Ensembl chr13:88,404,048...88,439,318

G

AKT serine/threonine kinase 1

decreases phosphorylation

ISO

bavachinin results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

BCL2, apoptosis regulator

decreases expression

ISO

bavachinin results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 1

multiple interactions
increases cleavage

ISO

[Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased activity of and results in increased cleavage of CASP1 protein; [ODN A151 co-treated with carnosol] inhibits the reaction [[Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased activity of and results in increased cleavage of CASP1 protein]; AIM2 protein affects the reaction [[Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased activity of and results in increased cleavage of CASP1 protein]; bavachinin promotes the reaction [Lipopolysaccharides results in increased cleavage of CASP1 protein]; carnosol inhibits the reaction [[Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased activity of and results in increased cleavage of CASP1 protein]; Lipopolysaccharides promotes the reaction [bavachinin results in increased cleavage of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased activity of and results in increased cleavage of CASP1 protein]; ODN A151 inhibits the reaction [[Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased activity of and results in increased cleavage of CASP1 protein]

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

caspase 9

decreases expression

ISO

bavachinin results in decreased expression of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

carboxylesterase 1D

decreases activity

ISO

bavachinin results in decreased activity of CES1 protein

NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449

G

collagen type II alpha 1 chain

multiple interactions

ISO

bavachinin inhibits the reaction [COL2A1 protein results in decreased expression of IL10 protein]; bavachinin inhibits the reaction [COL2A1 protein results in increased expression of IL1B mRNA]; bavachinin inhibits the reaction [COL2A1 protein results in increased expression of IL1B protein]; bavachinin inhibits the reaction [COL2A1 protein results in increased expression of IL6 mRNA]; bavachinin inhibits the reaction [COL2A1 protein results in increased expression of IL6 protein]; bavachinin inhibits the reaction [COL2A1 protein results in increased expression of TNF mRNA]; bavachinin inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]

NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627

G

cytochrome c, somatic

increases expression

ISO

bavachinin results in increased expression of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

glutamic--pyruvic transaminase

multiple interactions

ISO

[Lipopolysaccharides co-treated with bavachinin] results in increased expression of GPT protein; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Lipopolysaccharides co-treated with bavachinin] results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

gasdermin D

multiple interactions
increases cleavage

ISO

[Lipopolysaccharides co-treated with bavachinin] results in increased cleavage of GSDMD protein; [Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased cleavage of GSDMD protein; bavachinin promotes the reaction [Lipopolysaccharides results in increased expression of GSDMD mRNA]
bavachinin results in increased cleavage of GSDMD protein

NCBI chr 7:109,423,209...109,427,771
Ensembl chr 7:109,422,910...109,430,722

G

interleukin 10

increases expression
multiple interactions

ISO

bavachinin results in increased expression of IL10 mRNA; bavachinin results in increased expression of IL10 protein
bavachinin inhibits the reaction [COL2A1 protein results in decreased expression of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

decreases expression
multiple interactions

ISO

bavachinin results in decreased expression of IL1B mRNA; bavachinin results in decreased expression of IL1B protein
[Lipopolysaccharides co-treated with bavachinin] results in increased expression of IL1B mRNA; [Lipopolysaccharides co-treated with bavachinin] results in increased expression of IL1B protein; [Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased expression of IL1B protein; [ODN A151 co-treated with carnosol] inhibits the reaction [[Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased expression of IL1B protein]; AIM2 protein affects the reaction [[Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased expression of IL1B protein]; bavachinin inhibits the reaction [COL2A1 protein results in increased expression of IL1B mRNA]; bavachinin inhibits the reaction [COL2A1 protein results in increased expression of IL1B protein]; carnosol inhibits the reaction [[Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Lipopolysaccharides co-treated with bavachinin] results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased expression of IL1B protein]; ODN A151 inhibits the reaction [[Lipopolysaccharides results in increased susceptibility to bavachinin] which results in increased expression of IL1B protein]

PMID:37358659 PMID:38969277

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

decreases expression
multiple interactions

ISO

bavachinin results in decreased expression of IL6 mRNA; bavachinin results in decreased expression of IL6 protein
bavachinin inhibits the reaction [COL2A1 protein results in increased expression of IL6 mRNA]; bavachinin inhibits the reaction [COL2A1 protein results in increased expression of IL6 protein]; bavachinin promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]

PMID:37358659 PMID:38969277

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

immunity-related GTPase M

multiple interactions

ISO

[Lipopolysaccharides co-treated with bavachinin] results in increased expression of IRGM1 mRNA

NCBI chr10:33,734,640...33,742,720
Ensembl chr10:33,732,961...33,743,228

G

NIMA-related kinase 7

multiple interactions

ISO

[Lipopolysaccharides co-treated with bavachinin] results in increased expression of NEK7 mRNA

NCBI chr13:52,573,730...52,700,869
Ensembl chr13:52,573,730...52,700,823

G

NLR family, pyrin domain containing 3

multiple interactions

ISO

[Lipopolysaccharides co-treated with bavachinin] results in increased expression of NLRP3 mRNA

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

peroxisome proliferator-activated receptor gamma

increases expression

ISO

bavachinin results in increased expression of PPARG mRNA; bavachinin results in increased expression of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PYD and CARD domain containing

multiple interactions

ISO

[Lipopolysaccharides results in increased susceptibility to bavachinin] promotes the reaction [PYCARD protein binds to PYCARD protein]

NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419

G

tumor necrosis factor

decreases expression
multiple interactions

ISO

bavachinin results in decreased expression of TNF mRNA; bavachinin results in decreased expression of TNF protein
[Lipopolysaccharides co-treated with bavachinin] results in increased expression of TNF mRNA; [Lipopolysaccharides co-treated with bavachinin] results in increased expression of TNF protein; bavachinin inhibits the reaction [COL2A1 protein results in increased expression of TNF mRNA]; bavachinin inhibits the reaction [COL2A1 protein results in increased expression of TNF protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[Lipopolysaccharides co-treated with bavachinin] results in increased expression of TNF protein]

PMID:37358659 PMID:38969277

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

ISO

Diosmin binds to and results in increased activity of AHR protein

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

androgen receptor

multiple interactions

EXP

Diosmin inhibits the reaction [Testosterone Propionate results in increased expression of AR protein]

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

BCL2-associated agonist of cell death

multiple interactions

EXP

Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein]

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

EXP
ISO

[Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]

PMID:21477647 PMID:32061149

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions

EXP
ISO

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]

PMID:21477647 PMID:23665045 PMID:29187079 PMID:32061149

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 7

multiple interactions

EXP

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein]

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 9

multiple interactions

EXP

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein]

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

EXP

Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Diosmin inhibits the reaction [Testosterone Propionate results in decreased activity of CAT protein]

PMID:22056647 PMID:23665045 PMID:31797688

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

CEA cell adhesion molecule 1

multiple interactions

ISO

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of CEACAM1 protein]

NCBI chr 1:90,171,401...90,187,810
Ensembl chr 1:90,171,401...90,187,798

G

cAMP responsive element binding protein 1

multiple interactions

ISO

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of CREB1 protein]

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein]

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

enolase 2

multiple interactions

ISO

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of ENO2 protein]

NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220

G

glutathione peroxidase 1

multiple interactions

ISO

Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of and results in decreased activity of GPX1 protein]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione-disulfide reductase

multiple interactions

EXP
ISO

Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]; Diosmin inhibits the reaction [Testosterone Propionate results in decreased activity of GSR protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein]

PMID:23665045 PMID:31797688 PMID:32061149

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

interleukin 6

multiple interactions

ISO
EXP

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein]
Diosmin inhibits the reaction [Testosterone Propionate results in increased expression of IL6 protein]

PMID:31797688 PMID:32061149

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

kallikrein 1-related peptidase C10

multiple interactions

EXP

Diosmin inhibits the reaction [Testosterone Propionate results in increased expression of KLK3 protein]

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586

G

marker of proliferation Ki-67

multiple interactions

EXP

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein]

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

myeloperoxidase

multiple interactions

EXP

Diosmin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

nitric oxide synthase 2

multiple interactions

EXP

Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

poly (ADP-ribose) polymerase 1

multiple interactions

ISO

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

proliferating cell nuclear antigen

multiple interactions

EXP

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

prostaglandin E receptor 2

multiple interactions

ISO

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGER2 protein]

NCBI chr15:20,694,765...20,708,475
Ensembl chr15:20,696,013...20,708,950

G

prostaglandin-endoperoxide synthase 2

multiple interactions

EXP
ISO

Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein]; Diosmin inhibits the reaction [Testosterone Propionate results in increased expression of PTGS2 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]

PMID:23665045 PMID:29187079 PMID:31797688 PMID:32061149 PMID:35920545

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

tumor necrosis factor

multiple interactions

EXP

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:21477647 PMID:23665045 PMID:29187079

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions

EXP

Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

xanthine dehydrogenase

multiple interactions

EXP
ISO

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]; Diosmin inhibits the reaction [Testosterone Propionate results in increased activity of XDH protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein]

PMID:23665045 PMID:31797688 PMID:32061149

NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

eriocitrin results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

decreases expression

ISO

eriocitrin results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 7

increases expression

ISO

eriocitrin results in increased expression of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512

G

caspase 9

increases expression

ISO

eriocitrin results in increased expression of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

cyclin D1

decreases expression

ISO

eriocitrin results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

Janus kinase 2

decreases phosphorylation

ISO

eriocitrin results in decreased phosphorylation of JAK2 protein

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

ISO

Acetylcysteine inhibits the reaction [eriocitrin results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

proliferating cell nuclear antigen

decreases expression

ISO

eriocitrin results in decreased expression of PCNA protein

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

SRC proto-oncogene, non-receptor tyrosine kinase

decreases phosphorylation

ISO

eriocitrin results in decreased phosphorylation of SRC protein

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

signal transducer and activator of transcription 3

decreases phosphorylation

ISO

eriocitrin results in decreased phosphorylation of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

[ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol inhibits the reaction [[ABCB1 protein results in decreased susceptibility to Doxorubicin] promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of ABCB1 mRNA]]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

ATP binding cassette subfamily C member 1

decreases activity

ISO

eriodictyol results in decreased activity of ABCC1 protein

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

BCL2-related protein A1

multiple interactions

ISO

eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2A1 mRNA]

NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890

G

catalase

multiple interactions

EXP

eriodictyol inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO

eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin D1

multiple interactions

ISO

eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CCND1 mRNA]

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

C-X-C motif chemokine ligand 10

multiple interactions

ISO

eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

cytochrome c, somatic

increases expression

ISO

eriodictyol results in increased expression of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

ISO

eriodictyol results in decreased activity of CYP19A1 protein

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

glutamic--pyruvic transaminase

multiple interactions

EXP

eriodictyol inhibits the reaction [Arsenic Trioxide results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 4

decreases expression

ISO

eriodictyol results in decreased expression of GPX4 protein

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

glutathione S-transferase pi 1

decreases activity

ISO

eriodictyol results in decreased activity of GSTP1 protein

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

heme oxygenase 1

increases expression
decreases expression
multiple interactions

ISO
EXP

eriodictyol results in increased expression of HMOX1 protein
eriodictyol results in decreased expression of HMOX1 protein
bardoxolone methyl inhibits the reaction [eriodictyol results in decreased expression of HMOX1 protein]
eriodictyol results in increased expression of HMOX1 mRNA; eriodictyol results in increased expression of HMOX1 protein
eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]

PMID:16799064 PMID:28978146 PMID:37020356

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

interferon gamma

multiple interactions

ISO

eriodictyol inhibits the reaction [IFNG protein results in increased abundance of Nitrites]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 1 beta

multiple interactions

ISO

eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

PMID:21544733 PMID:31860763

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL6 mRNA]

PMID:20438634 PMID:21544733 PMID:31860763

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interferon regulatory factor 3

multiple interactions

ISO

eriodictyol inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]

NCBI chr 1:104,616,608...104,621,402
Ensembl chr 1:104,616,469...104,621,401

G

mitogen-activated protein kinase 8

multiple interactions

ISO

eriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

myeloperoxidase

multiple interactions

ISO

eriodictyol inhibits the reaction [Lipopolysaccharides results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

NFE2 like bZIP transcription factor 2

increases expression
decreases expression
decreases phosphorylation
multiple interactions

ISO
EXP

eriodictyol results in increased expression of NFE2L2 protein
eriodictyol results in decreased expression of NFE2L2 protein
eriodictyol results in decreased phosphorylation of NFE2L2 protein
bardoxolone methyl inhibits the reaction [eriodictyol results in decreased phosphorylation of NFE2L2 protein]
eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]
eriodictyol results in increased expression of NFE2L2 mRNA; eriodictyol results in increased expression of NFE2L2 protein

PMID:16799064 PMID:28978146 PMID:37020356

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO

eriodictyol inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]
eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein]

PMID:20438634 PMID:21544733

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

NLR family, pyrin domain containing 3

multiple interactions

ISO

eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]

NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394

G

NAD(P)H quinone dehydrogenase 1

decreases expression
multiple interactions

ISO

eriodictyol results in decreased expression of NQO1 protein
bardoxolone methyl inhibits the reaction [eriodictyol results in decreased expression of NQO1 protein]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

solute carrier family 7 member 11

decreases expression

ISO

eriodictyol results in decreased expression of SLC7A11 protein

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

TANK-binding kinase 1

decreases activity

ISO

eriodictyol results in decreased activity of TBK1 protein

NCBI chr 7:58,963,319...58,996,357
Ensembl chr 7:58,963,325...58,996,357

G

tumor necrosis factor

multiple interactions
decreases activity

ISO

eriodictyol inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; eriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
eriodictyol results in decreased activity of TNF protein

PMID:11123379 PMID:20438634 PMID:21544733 PMID:31860763

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF alpha induced protein 3

multiple interactions

ISO

eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNFAIP3 mRNA]

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:15,528,921...15,543,979

G

vascular endothelial growth factor A

multiple interactions

ISO

[ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; eriodictyol affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-fetoprotein

affects binding

EXP

flavanone binds to AFP protein

PMID:23013281 PMID:25349334

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

androgen receptor

affects binding

EXP

flavanone binds to AR protein

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

flavanone results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

caspase 3

multiple interactions

ISO

[benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone results in decreased activity of CASP3 protein] which results in decreased susceptibility to flavanone; flavanone results in increased cleavage of and results in increased activity of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

multiple interactions

ISO

[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] which results in decreased susceptibility to flavanone; flavanone results in increased cleavage of and results in increased activity of CASP8 protein

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

multiple interactions

ISO

flavanone results in increased cleavage of and results in increased activity of CASP9 protein

Ensembl chr 5:159,391,188...159,409,648

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

flavanone results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression

ISO

flavanone results in increased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

cytochrome c, somatic

affects localization

ISO

flavanone affects the localization of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
increases expression
decreases activity

ISO

flavanone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
flavanone results in increased expression of CYP1A1 mRNA
flavanone promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
flavanone results in decreased activity of CYP1A1 protein

PMID:17090139 PMID:20930378 PMID:21053930

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

ISO

flavanone results in decreased activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
increases expression

ISO

flavanone binds to and results in decreased activity of CYP1B1 protein
flavanone analog results in increased expression of CYP1B1 mRNA

PMID:21053930 PMID:31621310

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
decreases activity

ISO

flavanone inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; flavanone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]
flavanone results in decreased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

Fas cell surface death receptor

increases expression

ISO

flavanone results in increased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

Fas ligand

increases expression

ISO

flavanone results in increased expression of FASLG mRNA

NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503

G

monoamine oxidase A

decreases activity

ISO

flavanone results in decreased activity of MAOA protein

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

nuclear receptor subfamily 1, group I, member 3

increases activity

ISO

flavanone results in increased activity of NR1I3 protein

NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

flavanone results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

peroxisome proliferator-activated receptor gamma

increases expression

ISO

flavanone results in increased expression of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

phosphatase and tensin homolog

increases expression

ISO

flavanone results in increased expression of PTEN protein

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

RB transcriptional corepressor 1

decreases phosphorylation

ISO

flavanone results in decreased phosphorylation of RB1 protein

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857

G

sex hormone binding globulin

affects binding

ISO

flavanone binds to SHBG protein

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

G

tumor protein p53

multiple interactions

ISO

flavanone results in increased expression of and results in increased phosphorylation of TP53 protein

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

UDP glucuronosyltransferase family 1 member A1

increases expression

ISO

flavanone analog results in increased expression of UGT1A1 mRNA

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

multiple interactions

ISO

hesperetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; hesperetin inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]; hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:1,038,947...1,162,404

G

ATP binding cassette subfamily C member 4

multiple interactions

ISO

hesperetin inhibits the reaction [ABCC4 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]; hesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

ATP binding cassette subfamily C member 5

multiple interactions

ISO

hesperetin inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine]; hesperetin inhibits the reaction [ABCC5 protein results in increased export of 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein]

NCBI chr11:93,975,579...94,071,659
Ensembl chr11:93,978,274...94,071,655

G

actin alpha 2, smooth muscle

multiple interactions

EXP

[hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503

G

adiponectin, C1Q and collagen domain containing

decreases expression

ISO

hesperetin results in decreased expression of ADIPOQ mRNA

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

advanced glycosylation end product-specific receptor

multiple interactions

EXP

hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of AGER protein]

NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,151,965...4,155,685

G

aryl hydrocarbon receptor

increases activity
multiple interactions

ISO

hesperetin results in increased activity of AHR protein
[2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR protein]

PMID:17869316 PMID:21720915

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

AKT serine/threonine kinase 1

multiple interactions

EXP

hesperetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

albumin

multiple interactions

EXP

hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of ALB protein]

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

aldehyde dehydrogenase 4 family, member A1

affects binding

ISO

hesperetin binds to ALDH4A1 protein

NCBI chr 5:157,163,189...157,188,673
Ensembl chr 5:157,162,945...157,188,673

G

apurinic/apyrimidinic endodeoxyribonuclease 1

affects binding

ISO

hesperetin binds to APEX1 protein

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329

G

autophagy related 5

multiple interactions

EXP

hesperetin inhibits the reaction [Doxorubicin results in decreased expression of ATG5 mRNA]

NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821

G

BCL2 associated X, apoptosis regulator

affects expression
multiple interactions
increases expression

ISO
EXP

hesperetin affects the expression of BAX protein
[Cisplatin co-treated with hesperetin] results in decreased expression of BAX protein
hesperetin promotes the reaction [Cisplatin results in increased expression of BAX protein]
hesperetin analog results in increased expression of BAX protein; hesperetin results in increased expression of BAX mRNA; hesperetin results in increased expression of BAX protein
hesperetin analog results in increased expression of BAX mRNA

PMID:15975156 PMID:20564462 PMID:22142698 PMID:25345581 PMID:31153982 More...

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

affects expression
multiple interactions
decreases expression

ISO
EXP

hesperetin affects the expression of BCL2 protein
hesperetin promotes the reaction [Cisplatin results in increased expression of BCL2 protein]
hesperetin analog results in decreased expression of BCL2 protein; hesperetin results in decreased expression of BCL2 protein
hesperetin analog results in decreased expression of BCL2 mRNA

PMID:15975156 PMID:20564462 PMID:22142698 PMID:31153982 PMID:37487865

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

beclin 1

multiple interactions

EXP

hesperetin inhibits the reaction [Doxorubicin results in decreased expression of BECN1 mRNA]

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

caspase 3

affects cleavage
increases cleavage
multiple interactions
increases expression
increases activity

ISO
EXP

hesperetin affects the cleavage of CASP3 protein
hesperetin results in increased cleavage of CASP3 protein
Acetylcysteine inhibits the reaction [hesperetin results in increased cleavage of CASP3 protein]; hesperetin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
hesperetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]
hesperetin metabolite results in increased expression of CASP3 protein modified form; hesperetin results in increased expression of CASP3 protein modified form
hesperetin analog results in increased activity of CASP3 protein
hesperetin analog results in increased expression of CASP3 mRNA

PMID:15975156 PMID:19222219 PMID:20564462 PMID:22142698 PMID:31153982 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

catalase

increases activity
multiple interactions
decreases activity

ISO
EXP

hesperetin results in increased activity of CAT protein
hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]
hesperetin analog results in decreased activity of CAT protein; hesperetin results in decreased activity of CAT protein
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of CAT protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; hesperetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]

PMID:19023542 PMID:19222219 PMID:19497424 PMID:21134734 PMID:22142698 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 5

multiple interactions

ISO

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

cyclin D1

decreases expression
multiple interactions

ISO
EXP

hesperetin results in decreased expression of CCND1
hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of CCND1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]

PMID:17927510 PMID:27818223

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

copper chaperone for superoxide dismutase

affects binding

ISO

hesperetin binds to CCS protein

NCBI chr 1:211,543,192...211,564,354
Ensembl chr 1:211,542,701...211,564,260

G

cyclin dependent kinase 2

decreases expression

ISO

hesperetin results in decreased expression of CDK2

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

multiple interactions
decreases expression

ISO

hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein]
hesperetin results in decreased expression of CDK4

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

ISO

hesperetin promotes the reaction [CDK4 protein binds to CDKN1A protein]
hesperetin results in increased expression of CDKN1A; hesperetin results in increased expression of CDKN1A mRNA

PMID:17927510 PMID:25345581

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression

ISO

hesperetin results in increased expression of CDKN1B

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

CCAAT/enhancer binding protein alpha

decreases expression

ISO

hesperetin results in decreased expression of CEBPA protein

NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:96,896,171...96,899,309

G

collagen type I alpha 1 chain

multiple interactions

EXP

[hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

colony stimulating factor 3

multiple interactions

ISO

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of CSF3 protein]

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:84,157,211...84,159,860

G

cytochrome b5 type A

multiple interactions

EXP

hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYB5A protein]

NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094

G

cytochrome c, somatic

increases expression

ISO

hesperetin analog results in increased expression of CYCS protein; hesperetin results in increased expression of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

ISO

hesperetin results in decreased activity of CYP19A1 protein

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions
decreases activity

ISO

[2-hydroxypropyl-beta-cyclodextrin co-treated with hesperetin] inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
hesperetin results in decreased activity of CYP1A1 protein
hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]

PMID:10781868 PMID:21720915 PMID:26546711

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

ISO

hesperetin results in decreased activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

hesperetin results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

ISO

hesperetin results in decreased activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP

hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of CYP2E1 protein]

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

deleted in azoospermia-like

multiple interactions

EXP

hesperetin inhibits the reaction [Doxorubicin results in decreased expression of DAZL mRNA]

NCBI chr 9:18,193,363...18,210,100
Ensembl chr 9:18,193,363...18,210,100

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

ISO

hesperetin results in increased expression of DDIT3 protein
Acetylcysteine inhibits the reaction [hesperetin results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

dynamin 1-like

multiple interactions

EXP

hesperetin inhibits the reaction [Doxorubicin results in increased expression of DNM1L mRNA]; hesperetin inhibits the reaction [Doxorubicin results in increased expression of DNM1L protein]

NCBI chr11:98,084,049...98,135,663
Ensembl chr11:98,085,397...98,137,420

G

fatty acid binding protein 4

decreases expression

ISO

hesperetin results in decreased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

glucose-6-phosphate dehydrogenase

multiple interactions

EXP

hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein]

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

glutathione peroxidase 4

affects binding

ISO

hesperetin binds to GPX4 protein

NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:10,300,832...10,303,629

G

glycogen synthase kinase 3 beta

multiple interactions

EXP

hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of GSK3B protein]

NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249

G

glutathione-disulfide reductase

multiple interactions

EXP
ISO

hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of GSR protein]; hesperetin inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein]
hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased activity of GSR protein]

PMID:21134734 PMID:26546711 PMID:35567572

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

heme oxygenase 1

increases expression
multiple interactions

ISO

hesperetin results in increased expression of HMOX1 protein
[Cisplatin co-treated with hesperetin] results in increased expression of HMOX1 protein
hesperetin promotes the reaction [Cisplatin results in increased expression of HMOX1 protein]; hesperetin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMOX1 protein]

PMID:15316927 PMID:31153982

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

ISO

hesperetin results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [hesperetin results in increased expression of HSPA5 protein]

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

intercellular adhesion molecule 1

multiple interactions

EXP

hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of ICAM1 protein]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon gamma

multiple interactions

ISO

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 1 alpha

multiple interactions

ISO

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1A protein]

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

multiple interactions
affects expression

ISO
EXP

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]
hesperetin affects the expression of IL1B protein

PMID:24707119 PMID:24871567 PMID:28428136 PMID:32762101

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions
affects expression

ISO
EXP

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of IL6 protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein]; hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]
hesperetin affects the expression of IL6 protein

PMID:24707119 PMID:24871567 PMID:28428136 PMID:32762101 PMID:33522063 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Janus kinase 1

multiple interactions

ISO

hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of JAK1 protein]

NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:120,896,046...120,996,758

G

Janus kinase 2

multiple interactions

EXP

hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of JAK2 protein]

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

Kelch-like ECH-associated protein 1

affects binding

ISO

hesperetin binds to KEAP1 protein

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

lipoprotein lipase

decreases expression

ISO

hesperetin results in decreased expression of LPL mRNA

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

mitogen activated protein kinase 1

multiple interactions

ISO

hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

EXP
ISO

hesperetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]
[Cisplatin co-treated with hesperetin] results in decreased phosphorylation of MAPK8 protein
hesperetin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]

PMID:19222219 PMID:31153982

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

microRNA 150

multiple interactions

EXP

hesperetin inhibits the reaction [Doxorubicin results in decreased expression of MIR150 mRNA]

NCBI chr 1:104,741,487...104,741,571
Ensembl chr 1:104,741,487...104,741,571

G

microRNA 181b-2

multiple interactions

EXP

hesperetin inhibits the reaction [Doxorubicin results in decreased expression of MIR181B2 mRNA]

NCBI chr 3:43,026,666...43,026,753
Ensembl chr 3:43,026,666...43,026,753

G

microRNA 410

multiple interactions

ISO

hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of MIR410 mRNA]; MIR410 mRNA affects the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]

NCBI chr 6:134,579,763...134,579,838
Ensembl chr 6:134,579,759...134,579,839

G

myeloperoxidase

multiple interactions

ISO
EXP

hesperetin inhibits the reaction [Cisplatin results in increased expression of MPO protein]
hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

PMID:31153982 PMID:33522063

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mechanistic target of rapamycin kinase

multiple interactions

EXP

hesperetin inhibits the reaction [Doxorubicin results in increased expression of MTOR mRNA]; hesperetin inhibits the reaction [Doxorubicin results in increased expression of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

EXP

hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of MYC protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of MYC protein]

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

ISO

hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased expression of NFE2L2 protein]; hesperetin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]
[Cisplatin co-treated with hesperetin] results in increased expression of NFE2L2 protein
hesperetin results in increased expression of NFE2L2 protein

PMID:26546711 PMID:31153982

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nitric oxide synthase 2

multiple interactions

ISO
EXP

Hemin promotes the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of NOS2 protein]

PMID:12512693 PMID:15316927 PMID:35567572

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NADPH oxidase 4

decreases expression
multiple interactions

ISO

hesperetin results in decreased expression of NOX4 protein
hesperetin inhibits the reaction [Cisplatin results in increased expression of NOX4 protein]

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

EXP
ISO

hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in decreased activity of NQO1 protein]
hesperetin inhibits the reaction [Cisplatin results in decreased expression of NQO1 protein]
[Cisplatin co-treated with hesperetin] results in increased expression of NQO1 protein
hesperetin results in increased expression of NQO1 protein

PMID:19497424 PMID:31153982

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

N-ribosyldihydronicotinamide:quinone dehydrogenase 2

affects binding

ISO

hesperetin binds to NQO2 protein

NCBI chr17:31,114,825...31,144,062
Ensembl chr17:31,114,529...31,143,662

G

nuclear receptor subfamily 1, group I, member 2

increases activity

ISO

hesperetin results in increased activity of NR1I2 protein

NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380

G

proliferating cell nuclear antigen

multiple interactions

ISO
EXP

hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of PCNA protein]
hesperetin inhibits the reaction [Doxorubicin results in decreased expression of PCNA mRNA]

PMID:26546711 PMID:34933056

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

programmed cell death 6 interacting protein

decreases expression
multiple interactions

ISO

hesperetin results in decreased expression of PDCD6IP protein
Acetylcysteine inhibits the reaction [hesperetin results in decreased expression of PDCD6IP protein]

NCBI chr 8:122,469,223...122,524,993
Ensembl chr 8:122,469,223...122,524,993

G

cytochrome p450 oxidoreductase

multiple interactions

EXP

hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased activity of POR protein]

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809

G

peroxisome proliferator-activated receptor gamma

decreases expression
multiple interactions

ISO

hesperetin results in decreased expression of PPARG mRNA; hesperetin results in decreased expression of PPARG protein
[hesperetin analog co-treated with PPARG protein] affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of JAK1 protein]]; hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG protein]

PMID:25345581 PMID:28428136

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

phosphatase and tensin homolog

multiple interactions

EXP

hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in decreased expression of PTEN protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]

NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330

G

prostaglandin-endoperoxide synthase 2

multiple interactions
affects activity

ISO
EXP

hesperetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PTGS2 protein]
hesperetin affects the activity of PTGS2 protein

PMID:15240993 PMID:16101151 PMID:35567572

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO
EXP

hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of RELA protein]

PMID:26546711 PMID:35567572

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

resistin

decreases expression

ISO

hesperetin results in decreased expression of RETN mRNA

NCBI chr12:6,508,653...6,511,115
Ensembl chr12:6,508,801...6,511,116

G

sex hormone binding globulin

affects binding

ISO

hesperetin binds to SHBG protein

NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,831,718...54,838,760

G

sirtuin 3

affects binding

ISO

hesperetin binds to SIRT3 protein

NCBI chr 1:205,371,703...205,394,145
Ensembl chr 1:205,371,710...205,394,076

G

sirtuin 6

multiple interactions
increases expression

ISO

[Cisplatin co-treated with hesperetin] results in increased expression of SIRT6 protein
hesperetin results in increased expression of SIRT6 protein

NCBI chr 7:8,733,056...8,738,543
Ensembl chr 7:8,732,974...8,738,542

G

solute carrier family 16 member 1

multiple interactions

EXP

[hesperetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977

G

suppressor of cytokine signaling 3

multiple interactions

EXP

hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of SOCS3 protein]

NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825

G

superoxide dismutase 1

increases expression

ISO

hesperetin results in increased expression of SOD1 protein

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

superoxide dismutase 2

increases expression

ISO

hesperetin results in increased expression of SOD2 protein

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

SRY-box transcription factor 18

multiple interactions

ISO

hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]; MIR410 mRNA affects the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SOX18 protein]]

NCBI chr 3:189,163,000...189,164,802
Ensembl chr 3:189,163,002...189,164,802

G

signal transducer and activator of transcription 1

multiple interactions

ISO

hesperetin analog affects the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of STAT1 protein]

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346

G

signal transducer and activator of transcription 3

multiple interactions

EXP

hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased phosphorylation of STAT3 protein]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

transforming growth factor, beta 1

multiple interactions

EXP

[hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; [hesperetin analog co-treated with bisperoxovanadium analog] inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [bisperoxovanadium analog promotes the reaction [TGFB1 protein results in decreased expression of PTEN protein]]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in decreased expression of PTEN protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of CCND1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 protein]; hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of MYC protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]; PTEN protein promotes the reaction [hesperetin analog inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]]

PMID:27818223 PMID:34922902

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

tumor necrosis factor

multiple interactions
affects expression
decreases expression

ISO
EXP

[hesperetin analog co-treated with PPARG protein] affects the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; hesperetin analog inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; hesperetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; hesperetin inhibits the reaction [Benzo(a)pyrene results in increased expression of TNF protein]; hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; hesperetin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF protein]; hesperetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; MIR410 mRNA inhibits the reaction [hesperetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]
hesperetin inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of TNF protein]; hesperetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein]; hesperetin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
hesperetin affects the expression of TNF protein
hesperetin results in decreased expression of TNF mRNA

PMID:11123379 PMID:16934226 PMID:24871567 PMID:25345581 PMID:26546711 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [hesperetin results in increased expression of TP53 protein]; hesperetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of TP53 protein]

PMID:15795422 PMID:37487865

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1

affects binding

ISO

hesperetin binds to UQCRFS1 protein

NCBI chr17:34,173,787...34,190,952
Ensembl chr17:34,173,833...34,190,950

G

utrophin

increases expression

ISO

hesperetin results in increased expression of UTRN mRNA

NCBI chr 1:8,541,061...9,044,487
Ensembl chr 1:8,542,798...9,044,487

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

EXP

[bisphenol A diglycidyl ether co-treated with Hesperidin] inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein]; Hesperidin inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein]

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

actin gamma 2, smooth muscle

multiple interactions

EXP

hesperidin inhibits the reaction [ethanol increases expression of alpha SMA protein in liver parenchyma]

RGD

NCBI chr 4:117,579,513...117,604,379
Ensembl chr 4:117,579,514...117,604,295

G

alpha-fetoprotein

multiple interactions

EXP

Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]

PMID:28935427 PMID:30779474

NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,857,584...17,875,649

G

AKT serine/threonine kinase 1

multiple interactions

EXP

Hesperidin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of AKT1 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased activity of AKT1 protein]

PMID:30779474 PMID:35413380

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

AKT serine/threonine kinase 2

multiple interactions
increases expression

EXP

Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of AKT2 mRNA]
Hesperidin results in increased expression of AKT2 mRNA

NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420

G

albumin

multiple interactions
increases expression

ISO
EXP

[Hesperidin co-treated with Doxorubicin] results in increased expression of ALB protein
Hesperidin inhibits the reaction [Dichlorvos results in decreased expression of ALB protein]
Hesperidin results in increased expression of ALB protein

PMID:29481770 PMID:39733793

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865

G

activating transcription factor 6

multiple interactions
decreases expression

EXP

Hesperidin inhibits the reaction [abamectin results in increased expression of ATF6 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of ATF6 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of ATF6 mRNA]
Hesperidin results in decreased expression of ATF6 mRNA

PMID:34748272 PMID:35413380 PMID:36966900

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

EXP
ISO

[Hesperidin co-treated with Chlorpyrifos] results in increased expression of BAX mRNA; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of BAX mRNA]
Hesperidin inhibits the reaction [TNF protein results in increased expression of BAX protein]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of BAX protein]]
Doxorubicin promotes the reaction [Hesperidin results in increased expression of BAX mRNA]

PMID:24954035 PMID:29481770 PMID:32050098 PMID:33908150 PMID:34748272 More...

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

EXP
ISO

[Hesperidin co-treated with Chlorpyrifos] results in decreased expression of BCL2 mRNA; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Finasteride results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased expression of BCL2 mRNA]
Hesperidin inhibits the reaction [TNF protein results in decreased expression of BCL2 protein]
Hesperidin results in decreased expression of BCL2 mRNA
Doxorubicin promotes the reaction [Hesperidin results in decreased expression of BCL2 mRNA]

PMID:22093918 PMID:24954035 PMID:29481770 PMID:30623541 PMID:32050098 More...

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

beclin 1

multiple interactions
decreases expression

EXP

Hesperidin inhibits the reaction [abamectin results in increased expression of BECN1 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of BECN1 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of BECN1 protein]
Hesperidin results in decreased expression of BECN1 protein

PMID:33908150 PMID:34748272 PMID:35413380

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

bone morphogenetic protein 2

increases expression

EXP

Hesperidin results in increased expression of BMP2 mRNA

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760

G

caspase 3

multiple interactions
decreases expression
increases activity
increases expression

EXP
ISO

[Hesperidin co-treated with Chlorpyrifos] results in increased expression of CASP3 mRNA; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Dichlorvos results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Finasteride results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of CASP3 mRNA]; Hesperidin promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein]
Hesperidin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]
Hesperidin results in decreased expression of CASP3 protein
[Hesperidin co-treated with Doxorubicin] results in increased activity of CASP3 protein; Doxorubicin promotes the reaction [Hesperidin results in increased expression of CASP3 mRNA]
Hesperidin results in increased activity of CASP3 protein

PMID:22093918 PMID:29481770 PMID:30066062 PMID:30623541 PMID:30779474 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions

EXP

Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 protein]

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions
decreases activity
increases activity

EXP
ISO

Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [abamectin results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Dichlorvos results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Finasteride results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased activity of CAT protein]
Hesperidin results in decreased activity of CAT protein
Hesperidin results in increased activity of CAT protein
Hesperidin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]

PMID:22093918 PMID:29481770 PMID:30066062 PMID:30098279 PMID:30623541 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 3

multiple interactions

EXP

Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of CCL3 protein]; Hesperidin inhibits the reaction [Ethanol results in increased expression of CCL3 protein]

PMID:30368987 PMID:30811821

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 5

multiple interactions

ISO

Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

C-C motif chemokine ligand 7

multiple interactions

ISO

Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]]

NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947

G

cyclin D1

multiple interactions
decreases expression

ISO

BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CCND1 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CCND1 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CCND1 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CCND1 protein]
Hesperidin results in decreased expression of CCND1 mRNA; Hesperidin results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin dependent kinase 2

multiple interactions

EXP

Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of CDK2 protein]

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

multiple interactions
decreases expression

ISO

BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK4 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK4 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK4 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK4 protein]
Hesperidin results in decreased expression of CDK4 mRNA; Hesperidin results in decreased expression of CDK4 protein

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase 6

decreases expression
multiple interactions

ISO

Hesperidin results in decreased expression of CDK6 mRNA; Hesperidin results in decreased expression of CDK6 protein
BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK6 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK6 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK6 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK6 protein]

NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

ISO

BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1A mRNA]; BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1A protein]
Hesperidin results in increased expression of CDKN1A mRNA; Hesperidin results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression

ISO

BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1B mRNA]; BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1B protein]
Hesperidin results in increased expression of CDKN1B mRNA; Hesperidin results in increased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

C-X-C motif chemokine ligand 10

multiple interactions

ISO

Hesperidin inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]]

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261

G

C-X-C motif chemokine ligand 3

multiple interactions

ISO

Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,571,900...17,573,624

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases expression

EXP

Hesperidin inhibits the reaction [abamectin results in increased expression of EIF2AK3 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of EIF2AK3 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of EIF2AK3 mRNA]
Hesperidin results in increased expression of EIF2AK3 mRNA

PMID:34748272 PMID:35413380 PMID:36966900

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

EXP

Hesperidin inhibits the reaction [abamectin results in increased expression of ERN1 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of ERN1 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of ERN1 mRNA]

PMID:34748272 PMID:35413380 PMID:36966900

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

fatty acid binding protein 9

multiple interactions

EXP

Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of FABP9 protein]

NCBI chr 2:93,499,136...93,503,267
Ensembl chr 2:93,499,134...93,503,260

G

fatty acid synthase

multiple interactions

ISO

Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein]

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

glucose 6 phosphatase catalytic subunit 3

multiple interactions

EXP

Hesperidin inhibits the reaction [Streptozocin results in decreased activity of G6PC3 protein]

NCBI chr10:87,647,149...87,651,385
Ensembl chr10:87,647,062...87,653,453

G

glucose-6-phosphate dehydrogenase

decreases activity
multiple interactions

ISO
EXP

Hesperidin results in decreased activity of G6PD protein
Hesperidin inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]
Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]

PMID:16427799 PMID:25130191 PMID:31345080

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

glucokinase

multiple interactions

ISO

Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA]

NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949

G

glutamic--pyruvic transaminase

decreases activity
multiple interactions

ISO
EXP

Hesperidin results in decreased activity of GPT protein
Hesperidin inhibits the reaction [Chlorpyrifos results in increased activity of GPT protein]; Hesperidin inhibits the reaction [Dichlorvos results in increased activity of GPT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of GPT protein]
[Doxorubicin co-treated with Hesperidin] results in decreased activity of GPT protein

PMID:29481770 PMID:30066062 PMID:30779474 PMID:33908150 PMID:39733793

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione-disulfide reductase

multiple interactions

EXP

Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]

PMID:22093918 PMID:30098279

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

hepatitis A virus cellular receptor 1

multiple interactions

EXP

Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 protein]

PMID:22093918 PMID:30098279

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

histone deacetylase 1

multiple interactions

ISO

Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]]

NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:147,138,156...147,165,387

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

ISO
EXP

Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]
Hesperidin inhibits the reaction [Dichlorvos results in decreased activity of HMGCR protein]

PMID:16427799 PMID:39733793

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

heme oxygenase 1

multiple interactions

EXP

Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of HMOX1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of HMOX1 mRNA]

PMID:28935427 PMID:32050098 PMID:34748272 PMID:35921949 PMID:36966900

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions

EXP

Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein]

NCBI chr 2:188,858,574...188,864,694

G

heat shock protein family A (Hsp70) member 5

multiple interactions

EXP

Hesperidin inhibits the reaction [abamectin results in increased expression of HSPA5 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of HSPA5 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 mRNA]

PMID:34748272 PMID:35413380 PMID:36966900

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

intercellular adhesion molecule 1

multiple interactions

ISO

Hesperidin inhibits the reaction [Glucose results in increased expression of ICAM1]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]

PMID:17400256 PMID:22074828

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interleukin 10

multiple interactions

EXP

Hesperidin inhibits the reaction [Dichlorvos results in decreased expression of IL10 mRNA]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

multiple interactions

ISO
EXP

Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B protein]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B protein]]
Hesperidin inhibits the reaction [abamectin results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of IL1B protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

PMID:17400256 PMID:30066062 PMID:33908150 PMID:34748272 PMID:35413380 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 4

multiple interactions

ISO

Hesperidin promotes the reaction [Lipopolysaccharides results in increased expression of IL4 protein]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions
decreases expression

ISO
EXP

Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
hesperidin inhibits the reaction [ethanol increases expression of IL6 in liver]
Hesperidin results in decreased expression of IL6 protein
[naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; Hesperidin inhibits the reaction [abamectin results in increased expression of IL6 mRNA]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL6 mRNA]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]

CTD
RGD

PMID:17400256 PMID:21820093 PMID:30066062 PMID:30623541 PMID:34748272 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Janus kinase 2

multiple interactions

EXP

Hesperidin inhibits the reaction [abamectin results in increased expression of JAK2 mRNA]

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762

G

leptin

decreases expression
multiple interactions

EXP

Hesperidin results in decreased expression of LEP protein
[naringin co-treated with Hesperidin] results in decreased expression of LEP protein

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

leptin receptor

multiple interactions

ISO

Hesperidin affects the reaction [LEPR protein affects the abundance of Glucose]; Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein]; Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]; Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]; Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA]; Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein]

NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215

G

microtubule-associated protein 1 light chain 3 alpha

multiple interactions

EXP

Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3A mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAP1LC3A mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of MAP1LC3A protein]

PMID:34748272 PMID:35413380 PMID:35921949

NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:164,243,093...164,244,850

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

EXP

Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3B mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAP1LC3B mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of MAP1LC3B protein]

PMID:34748272 PMID:35413380 PMID:35921949

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

mitogen activated protein kinase kinase 5

decreases phosphorylation

ISO

Hesperidin results in decreased phosphorylation of MAP2K5 protein

NCBI chr 8:72,520,616...72,748,395
Ensembl chr 8:72,520,617...72,747,373

G

mitogen activated protein kinase 14

multiple interactions

EXP

Hesperidin inhibits the reaction [abamectin results in increased expression of MAPK14 mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of MAPK14 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAPK14 mRNA]

PMID:33908150 PMID:34748272 PMID:35921949

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen-activated protein kinase 7

multiple interactions

ISO

BIX 02189 promotes the reaction [Hesperidin results in decreased phosphorylation of MAPK7 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased phosphorylation of MAPK7 protein]; Hesperidin results in decreased phosphorylation of and affects the localization of MAPK7 protein

NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,669,721...46,675,806

G

mitogen-activated protein kinase 8

multiple interactions

ISO

Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions

ISO

Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

microRNA 126b

multiple interactions

EXP

Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MIR126B mRNA]

NCBI chr 3:29,813,174...29,813,246

G

microRNA 181a-2

multiple interactions

EXP

Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MIR181A2 mRNA]

NCBI chr 3:43,025,563...43,025,679
Ensembl chr 3:43,025,563...43,025,679

G

matrix metallopeptidase 2

multiple interactions

EXP

Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MMP2 mRNA]

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

multiple interactions
decreases secretion

ISO
EXP

Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of and results in increased activity of MMP9 protein]; Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of MMP9 mRNA]; Hesperidin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MMP9 mRNA]
Hesperidin results in decreased secretion of MMP9 protein

PMID:19110045 PMID:20138977 PMID:35921949

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

multiple interactions
decreases activity

EXP

Hesperidin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]
Hesperidin results in decreased activity of MPO protein

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

mechanistic target of rapamycin kinase

multiple interactions

EXP

Hesperidin inhibits the reaction [Sodium Fluoride results in decreased expression of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

EXP

Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of NFE2L2 mRNA]
Hesperidin results in increased expression of NFE2L2 mRNA

PMID:28935427 PMID:32050098 PMID:34748272 PMID:35921949 PMID:36966900

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions
increases expression

EXP

Hesperidin inhibits the reaction [abamectin results in increased expression of NFKB1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NFKB1 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of NFKB1 mRNA]
Hesperidin results in increased expression of NFKB1 mRNA

PMID:22093918 PMID:34748272 PMID:35921949 PMID:36966900

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

multiple interactions

ISO

Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

multiple interactions

EXP
ISO

Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of NOS2 protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:12512693 PMID:22093918 PMID:33908150

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

poly (ADP-ribose) polymerase 1

multiple interactions

EXP

[Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 mRNA; [Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 protein; Hesperidin inhibits the reaction [Ethanol results in increased activity of PARP1 protein]

PMID:30368987 PMID:33908150

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

proliferating cell nuclear antigen

multiple interactions

EXP

Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of PCNA protein]

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

EXP

Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein]

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

peroxisome proliferator-activated receptor gamma

multiple interactions

EXP
ISO

Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG protein]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]
Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]

PMID:16427799 PMID:24954035 PMID:28935427 PMID:30623541

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPARG coactivator 1 alpha

multiple interactions

EXP

Hesperidin inhibits the reaction [Dextran Sulfate results in decreased expression of PPARGC1A protein]; Hesperidin inhibits the reaction [Ethanol results in decreased expression of PPARGC1A protein]

PMID:30368987 PMID:30811821

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO
EXP

Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]
Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of PTGS2 mRNA]

PMID:16101151 PMID:19110045 PMID:30098279 PMID:33908150

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP
ISO

Hesperidin inhibits the reaction [Dichlorvos results in increased expression of RELA mRNA]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of RELA protein]
Hesperidin inhibits the reaction [TNF protein results in increased expression of RELA protein]; Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of RELA protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]]

PMID:30623541 PMID:39733793 PMID:39987982

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

sphingosine-1-phosphate phosphatase 2

multiple interactions

EXP

Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SGPP2 mRNA]

NCBI chr 9:87,211,155...87,331,787
Ensembl chr 9:87,211,717...87,333,132

G

sirtuin 1

multiple interactions

EXP

Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

solute carrier family 1 member 2

multiple interactions

ISO

Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein]

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249

G

solute carrier family 2 member 2

multiple interactions

ISO

Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]

NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467

G

solute carrier family 2 member 4

multiple interactions

ISO

Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein]

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

superoxide dismutase 2

multiple interactions

EXP

Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 protein]

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

sphingosine kinase 1

multiple interactions

EXP

Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein]

NCBI chr10:102,257,413...102,263,086
Ensembl chr10:102,258,975...102,263,082

G

signal transducer and activator of transcription 3

multiple interactions

EXP

Hesperidin inhibits the reaction [abamectin results in increased expression of STAT3 mRNA]

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

transcription factor EB

multiple interactions

EXP

Hesperidin inhibits the reaction [Ethanol results in decreased expression of TFEB mRNA]

NCBI chr 9:20,696,440...20,752,265
Ensembl chr 9:20,696,441...20,727,863

G

transforming growth factor, beta 1

multiple interactions

EXP

hesperidin inhibits the reaction [ethanol increases expression of TGFbeta protein in serum]

RGD

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

toll-like receptor 4

multiple interactions

ISO

Hesperidin inhibits the reaction [TNF protein results in increased expression of TLR4 protein]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of TLR4 protein]]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tenascin C

multiple interactions

EXP

Hesperidin inhibits the reaction [Ethanol results in increased expression of TNC protein]

NCBI chr 5:82,391,340...82,476,197
Ensembl chr 5:82,391,340...82,476,131

G

tumor necrosis factor

multiple interactions
decreases expression

ISO
EXP

Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]; Hesperidin inhibits the reaction [TNF protein results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of BAX protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]; Hesperidin inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of RELA protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of TLR4 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of BAX protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of RELA protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of TLR4 protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]]
Hesperidin results in decreased expression of TNF mRNA
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of TNF protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of TNF mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of TNF mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of TNF protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of TNF protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:17400256 PMID:28935427 PMID:30066062 PMID:30623541 PMID:33908150 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 25

increases expression

ISO

Hesperidin results in increased expression of TNFRSF25 mRNA

NCBI chr 5:167,904,377...167,909,052
Ensembl chr 5:167,904,786...167,909,052

G

tumor protein p53

multiple interactions

EXP

Hesperidin inhibits the reaction [sodium arsenite results in increased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

TNFRSF1A-associated via death domain

increases expression

ISO

Hesperidin results in increased expression of TRADD mRNA

NCBI chr19:50,046,057...50,048,158
Ensembl chr19:50,046,061...50,052,550

G

Traf3 interacting protein 2

multiple interactions

ISO

TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of BAX protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CCL7 mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of IL1B protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of RELA protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased expression of TLR4 protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]]; TRAF3IP2 protein inhibits the reaction [Hesperidin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]]

NCBI chr20:44,565,992...44,609,240
Ensembl chr20:44,517,242...44,609,618

G

vascular cell adhesion molecule 1

multiple interactions
decreases expression

ISO

Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Hesperidin results in decreased expression of VCAM1

PMID:17400256 PMID:30991044

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

vascular endothelial growth factor A

multiple interactions

EXP

[Hesperidin co-treated with Chlorpyrifos] results in increased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

YY1 transcription factor

multiple interactions

ISO

Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of and affects the localization of YY1 protein]

NCBI chr 6:133,471,615...133,500,875
Ensembl chr 6:133,471,562...133,497,257

homoeriodictyol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis inducing factor, mitochondria associated 1

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the localization of AIFM1 protein]

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:132,528,107...132,567,237

G

BCL2, apoptosis regulator

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 1

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2L1 protein]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

caspase 3

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]

Ensembl chr 5:159,391,188...159,409,648

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein]

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:252,908,749...252,944,273

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

ISO

homoeriodictyol results in decreased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

ISO

homoeriodictyol results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

glutamate cysteine ligase, modifier subunit

increases expression

ISO

homoeriodictyol results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

ghrelin and obestatin prepropeptide

multiple interactions

ISO

[homoeriodictyol co-treated with Glucose] results in increased secretion of GHRL protein

NCBI chr 4:148,421,315...148,431,128
Ensembl chr 4:148,421,315...148,425,969

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911

G

interleukin 1 beta

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

homoeriodictyol results in increased expression of and results in increased localization of NFE2L2 protein; homoeriodictyol results in increased stability of and results in increased expression of and results in increased activity of NFE2L2 protein; NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

ISO

homoeriodictyol results in increased expression of NQO1 mRNA
NFE2L2 protein affects the reaction [homoeriodictyol results in increased expression of NQO1 protein]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

poly (ADP-ribose) polymerase 1

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased localization of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

tumor necrosis factor

multiple interactions

ISO

homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; homoeriodictyol inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation
multiple interactions

ISO

isobavachin results in decreased phosphorylation of AKT1 protein
3-methyladenine inhibits the reaction [isobavachin results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

androgen receptor

decreases localization
multiple interactions
decreases expression

ISO

isobavachin results in decreased localization of AR protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [isobavachin results in decreased expression of and results in increased degradation of AR protein]; isobavachin binds to and results in decreased activity of AR protein; isobavachin results in decreased expression of and results in increased degradation of AR protein
isobavachin results in decreased expression of AR protein

NCBI chr X:67,135,317...67,304,476
Ensembl chr X:67,135,317...67,304,467

G

beclin 1

increases expression

ISO

isobavachin results in increased expression of BECN1 protein

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002

G

caspase 1

multiple interactions

ISO

[Lipopolysaccharides results in increased susceptibility to isobavachin] which results in increased activity of and results in increased cleavage of CASP1 protein

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275

G

interleukin 1 beta

multiple interactions

ISO

[Lipopolysaccharides results in increased susceptibility to isobavachin] which results in increased expression of IL1B protein

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

kallikrein 1-related peptidase C10

decreases expression

ISO

isobavachin results in decreased expression of KLK3 mRNA; isobavachin results in decreased expression of KLK3 protein

NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:103,539,527...103,543,586

G

microtubule-associated protein 1 light chain 3 alpha

multiple interactions

ISO

3-methyladenine inhibits the reaction [isobavachin results in increased lipidation of and results in increased localization of MAP1LC3A protein]; isobavachin results in increased lipidation of and results in increased localization of MAP1LC3A protein

NCBI chr 3:164,243,204...164,244,850
Ensembl chr 3:164,243,093...164,244,850

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

ISO

3-methyladenine inhibits the reaction [isobavachin results in increased lipidation of and results in increased localization of MAP1LC3B protein]; isobavachin results in increased lipidation of and results in increased localization of MAP1LC3B protein

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358

G

microtubule-associated protein tau

decreases phosphorylation

ISO

isobavachin results in decreased phosphorylation of MAPT protein

NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108

G

mechanistic target of rapamycin kinase

multiple interactions

ISO

3-methyladenine inhibits the reaction [isobavachin results in decreased phosphorylation of MTOR protein]; PRKAA1 protein promotes the reaction [isobavachin results in decreased phosphorylation of MTOR protein]; PRKAA2 protein promotes the reaction [isobavachin results in decreased phosphorylation of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

progesterone receptor

multiple interactions
increases expression

ISO

Fulvestrant inhibits the reaction [isobavachin results in increased expression of PGR mRNA]; Fulvestrant inhibits the reaction [isobavachin results in increased expression of PGR protein]
isobavachin results in increased expression of PGR mRNA; isobavachin results in increased expression of PGR protein

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions
increases phosphorylation

ISO

PRKAA1 protein promotes the reaction [isobavachin results in decreased expression of SQSTM1 protein]; PRKAA1 protein promotes the reaction [isobavachin results in decreased phosphorylation of MTOR protein]; PRKAA1 protein promotes the reaction [isobavachin results in increased phosphorylation of ULK1 protein]
isobavachin results in increased phosphorylation of PRKAA1 protein

NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450

G

protein kinase AMP-activated catalytic subunit alpha 2

increases phosphorylation
multiple interactions

ISO

isobavachin results in increased phosphorylation of PRKAA2 protein
PRKAA2 protein promotes the reaction [isobavachin results in decreased expression of SQSTM1 protein]; PRKAA2 protein promotes the reaction [isobavachin results in decreased phosphorylation of MTOR protein]; PRKAA2 protein promotes the reaction [isobavachin results in increased phosphorylation of ULK1 protein]

NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324

G

sequestosome 1

decreases expression
multiple interactions

ISO

isobavachin results in decreased expression of SQSTM1 protein
3-methyladenine inhibits the reaction [isobavachin results in decreased expression of SQSTM1 protein]; PRKAA1 protein promotes the reaction [isobavachin results in decreased expression of SQSTM1 protein]; PRKAA2 protein promotes the reaction [isobavachin results in decreased expression of SQSTM1 protein]

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

trefoil factor 1

increases expression
multiple interactions

ISO

isobavachin results in increased expression of TFF1 mRNA
Fulvestrant inhibits the reaction [isobavachin results in increased expression of TFF1 mRNA]

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956

G

unc-51 like autophagy activating kinase 1

multiple interactions
increases phosphorylation

ISO

3-methyladenine inhibits the reaction [isobavachin results in increased phosphorylation of ULK1 protein]; PRKAA1 protein promotes the reaction [isobavachin results in increased phosphorylation of ULK1 protein]; PRKAA2 protein promotes the reaction [isobavachin results in increased phosphorylation of ULK1 protein]

NCBI chr12:51,511,492...51,537,746
Ensembl chr12:51,511,492...51,537,746

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1 member B10

decreases activity

ISO

isoxanthohumol results in decreased activity of AKR1B10 protein

NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:64,007,420...64,020,847

G

aldo-keto reductase family 1, member C3

decreases activity

ISO

isoxanthohumol results in decreased activity of AKR1C3 protein

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438

G

carbonyl reductase 1

multiple interactions
decreases activity

ISO

isoxanthohumol inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; isoxanthohumol inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]
isoxanthohumol results in decreased activity of CBR1 protein

PMID:30849340 PMID:35065925

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104

G

cytochrome P450, family 1, subfamily a, polypeptide 2

increases expression

ISO

isoxanthohumol results in increased expression of CYP1A2 mRNA

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

estrogen receptor 1

increases activity

ISO

isoxanthohumol results in increased activity of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Bcl2-like 1

decreases expression
multiple interactions

ISO

kurarinol results in decreased expression of BCL2L1 mRNA; kurarinol results in decreased expression of BCL2L1 protein
kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907

G

caspase 3

increases activity
multiple interactions

ISO

kurarinol results in increased activity of CASP3 protein
STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

cyclin D1

decreases expression

ISO

kurarinol results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

ISO

kurarinol results in decreased expression of MCL1 mRNA; kurarinol results in decreased expression of MCL1 protein

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

signal transducer and activator of transcription 3

multiple interactions
decreases phosphorylation

ISO

kurarinol inhibits the reaction [STAT3 protein binds to BCL2L1 promoter]; STAT3 protein inhibits the reaction [kurarinol results in increased activity of CASP3 protein]
kurarinol results in decreased phosphorylation of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

protein tyrosine phosphatase, non-receptor type 1

decreases activity

ISO

kuwanon-L results in decreased activity of PTPN1 protein

NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

multiple interactions

ISO
EXP

liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-X-C motif chemokine ligand 12

increases expression

ISO

liquiritigenin results in increased expression of CXCL12 mRNA

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

ISO

liquiritigenin results in decreased activity of CYP19A1 protein

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

ISO

liquiritigenin results in decreased activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

estrogen receptor 1

increases activity

ISO

liquiritigenin results in increased activity of ESR1 protein

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

increases activity

ISO

liquiritigenin results in increased activity of ESR2 protein

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

EXP

liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA]
liquiritigenin results in increased expression of GCLC protein

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

increases expression
multiple interactions

EXP

liquiritigenin results in increased expression of GCLM protein
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glutamic--pyruvic transaminase

multiple interactions

EXP

liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione-disulfide reductase

multiple interactions

EXP

liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

heme oxygenase 1

multiple interactions

EXP

liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA]

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein family D (Hsp60) member 1

multiple interactions

ISO
EXP

liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]; liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]
liquiritigenin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

interleukin 6

multiple interactions

ISO
EXP

liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

matrix metallopeptidase 9

multiple interactions

EXP

liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]

PMID:29908794 PMID:31589899

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

multiple interactions

EXP

liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

NFE2 like bZIP transcription factor 2

decreases response to substance
multiple interactions

ISO
EXP

NFE2L2 gene mutant form results in decreased susceptibility to liquiritigenin
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nitric oxide synthase 2

multiple interactions

EXP
ISO

liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]
liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

ISO
EXP

liquiritigenin results in increased expression of NQO1 protein
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA]

PMID:26473469 PMID:29908794

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO
EXP

liquiritigenin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]
liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

sequestosome 1

multiple interactions

EXP

liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein]

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

toll-like receptor 4

multiple interactions

EXP

liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

transient receptor potential cation channel, subfamily M, member 3

decreases activity

ISO

liquiritigenin results in decreased activity of TRPM3 protein

NCBI chr 1:229,099,741...229,984,172
Ensembl chr 1:229,099,542...229,984,172

G

TSC22 domain family, member 3

multiple interactions

ISO

liquiritigenin inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA]

NCBI chr X:109,006,410...109,066,389
Ensembl chr X:109,006,420...109,015,519

G

thioredoxin 2

multiple interactions

EXP

liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein]

NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:111,386,805...111,390,022

G

thioredoxin reductase 2

multiple interactions

EXP

liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein]

NCBI chr11:96,024,321...96,072,475
Ensembl chr11:96,024,324...96,072,475

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

multiple interactions

ISO

[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCB11 mRNA

NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581

G

ATP binding cassette subfamily C member 2

multiple interactions

ISO

[liquiritin co-treated with 1-Naphthylisothiocyanate] results in decreased expression of ABCC2 mRNA

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471

G

ATP binding cassette subfamily C member 3

multiple interactions

ISO

[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC3 mRNA

NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494

G

ATP binding cassette subfamily C member 4

multiple interactions

ISO

[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC4 mRNA

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:101,949,433...102,181,375

G

adrenoceptor beta 2

multiple interactions

ISO

liquiritin inhibits the reaction [Epinephrine results in increased activity of ADRB2 protein]

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:57,911,348...57,914,803

G

C-C motif chemokine ligand 2

multiple interactions

EXP
ISO

liquiritin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA]
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP

[brucine co-treated with liquiritin] results in decreased activity of CYP2E1 protein

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

EXP

liquiritin results in increased expression of GCLC protein
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

multiple interactions
increases expression

EXP

liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]
liquiritin results in increased expression of GCLM protein

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

glutamic--pyruvic transaminase

multiple interactions

EXP
ISO

liquiritin inhibits the reaction [Monocrotaline results in increased activity of GPT protein]
liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of GPT protein]

PMID:31589899 PMID:36008890

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione-disulfide reductase

multiple interactions

EXP

liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

heme oxygenase 1

multiple interactions

EXP
ISO

liquiritin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA]
[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of HMOX1 mRNA; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of HMOX1 protein]

PMID:29908794 PMID:36008890

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

heat shock protein family D (Hsp60) member 1

multiple interactions

ISO
EXP

liquiritin inhibits the reaction [HSPD1 protein results in increased expression of CCL2 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]; liquiritin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]
liquiritin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:64,073,611...64,084,037

G

interleukin 1 beta

multiple interactions

ISO

liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO
EXP

liquiritin inhibits the reaction [HSPD1 protein results in increased expression of IL6 mRNA]
liquiritin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

Kelch-like ECH-associated protein 1

multiple interactions

ISO

liquiritin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of KEAP1 protein]

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

matrix metallopeptidase 9

multiple interactions

EXP

liquiritin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]

PMID:29908794 PMID:31589899

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

multiple interactions

EXP

liquiritin inhibits the reaction [Monocrotaline results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

NFE2 like bZIP transcription factor 2

decreases response to substance
multiple interactions

ISO
EXP

NFE2L2 gene mutant form results in decreased susceptibility to liquiritin
liquiritin promotes the reaction [1-Naphthylisothiocyanate results in increased expression of NFE2L2 protein]
liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA]

PMID:29908794 PMID:36008890

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nitric oxide synthase 2

multiple interactions

EXP
ISO

liquiritin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of NOS2 mRNA]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

EXP
ISO

liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA]
[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of NQO1 mRNA

PMID:29908794 PMID:36008890

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

ISO

liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 mRNA]; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of NR1H4 protein]

NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:25,733,471...25,829,389

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP
ISO

liquiritin inhibits the reaction [Monocrotaline results in increased expression of RELA protein]
liquiritin inhibits the reaction [HSPD1 protein results in increased expression of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

sirtuin 1

multiple interactions

ISO

liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SIRT1 mRNA]; liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SIRT1 protein]

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

solute carrier family 10 member 1

multiple interactions

ISO

liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]

NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944

G

sequestosome 1

multiple interactions

EXP

liquiritin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein]

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750

G

toll-like receptor 4

multiple interactions

EXP

liquiritin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein]

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007

G

tumor necrosis factor

multiple interactions

ISO

liquiritin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of TNF protein]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

thioredoxin 2

multiple interactions

EXP

liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein]

NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:111,386,805...111,390,022

G

thioredoxin reductase 2

multiple interactions

EXP

liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein]

NCBI chr11:96,024,321...96,072,475
Ensembl chr11:96,024,324...96,072,475

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nuclear receptor subfamily 1, group H, member 3

increases expression

ISO

Naringenin increases expression of NR1H3 mRNA and protein in macrophages

RGD

NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

ISO

naringin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

acetyl-CoA carboxylase alpha

multiple interactions

ISO

[naringin co-treated with Dietary Fats] results in decreased expression of ACACA mRNA

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

angiotensin I converting enzyme

multiple interactions

EXP

naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACE protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of ACE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of ACE protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]

PMID:32172062 PMID:32810514

NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942

G

acetylcholinesterase

multiple interactions

EXP

[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of ACHE protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein]; naringin inhibits the reaction [[potassium bromate co-treated with Caffeine] results in increased activity of ACHE protein]; naringin inhibits the reaction [bisphenol A results in increased activity of ACHE protein]; naringin inhibits the reaction [Caffeine results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]; naringin inhibits the reaction [potassium bromate results in increased activity of ACHE protein]

PMID:32172062 PMID:32428650 PMID:32810514 PMID:37865952

NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410

G

acyl-CoA oxidase 1

multiple interactions

ISO

naringin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136

G

acid phosphatase 5, tartrate resistant

multiple interactions
decreases expression

ISO

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [Polymethyl Methacrylate analog results in increased expression of and results in increased activity of ACP5 protein]
naringin results in decreased expression of ACP5 mRNA

PMID:21835177 PMID:24376342

NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929

G

adenosine deaminase

multiple interactions

EXP

naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein]; naringin inhibits the reaction [[potassium bromate co-treated with Caffeine] results in increased activity of ADA protein]; naringin inhibits the reaction [bisphenol A results in increased activity of ADA protein]; naringin inhibits the reaction [Caffeine results in increased activity of ADA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ADA protein]; naringin inhibits the reaction [potassium bromate results in increased activity of ADA protein]

PMID:32172062 PMID:32428650 PMID:32810514 PMID:37865952

NCBI chr 3:172,818,174...172,842,283
Ensembl chr 3:172,818,176...172,842,293

G

adiponectin, C1Q and collagen domain containing

multiple interactions

ISO

naringin inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169

G

angiotensinogen

multiple interactions

ISO

naringin inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA]; naringin inhibits the reaction [AGT protein results in increased secretion of Aldosterone]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

aldo-keto reductase family 7, member A2

multiple interactions

ISO

naringin inhibits the reaction [Acetaminophen results in decreased expression of AKR7A5 protein]

NCBI chr 5:156,835,589...156,844,127
Ensembl chr 5:156,835,551...156,844,109

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

EXP
ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]; naringin inhibits the reaction [Methylprednisolone results in decreased phosphorylation of AKT1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; plerixafor inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]
naringin inhibits the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of AKT1 mRNA]

PMID:19810018 PMID:25773745 PMID:29510123 PMID:30878453

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

angiopoietin 1

affects expression

EXP

naringin affects the expression of ANGPT1 mRNA

NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:75,418,218...75,668,696

G

apoptotic peptidase activating factor 1

increases expression
multiple interactions

ISO

naringin results in increased expression of APAF1 protein
Acetylcysteine inhibits the reaction [naringin results in decreased expression of APAF1 protein]

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772

G

aquaporin 1

multiple interactions

ISO

naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein]

NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504

G

aquaporin 5

multiple interactions

ISO

naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein]

NCBI chr 7:132,601,528...132,605,060
Ensembl chr 7:132,601,059...132,605,062

G

activating transcription factor 6

multiple interactions
increases expression

EXP
ISO

naringin inhibits the reaction [Oxaliplatin results in increased expression of ATF6 mRNA]
naringin results in increased expression of ATF6 protein

PMID:38037725 PMID:39056589

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033

G

ATPase H+ transporting V0 subunit D2

multiple interactions

ISO

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]

NCBI chr 5:38,133,151...38,182,245
Ensembl chr 5:38,133,158...38,182,245

G

BCL2-associated agonist of cell death

multiple interactions

EXP
ISO

naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAD mRNA]
naringin inhibits the reaction [Dexamethasone results in increased phosphorylation of BAD protein]

PMID:21945202 PMID:30878453

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

ISO
EXP

naringin results in increased expression of BAX mRNA; naringin results in increased expression of BAX protein
CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of BAX protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of BAX protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]
Acetylcysteine inhibits the reaction [naringin results in increased expression of BAX protein]; naringin inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [Acrylamide results in increased expression of BAX protein]; naringin inhibits the reaction [Oxaliplatin results in increased expression of BAX mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of BAX protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]

PMID:21945202 PMID:22847135 PMID:28422390 PMID:30130594 PMID:30878453 More...

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

butyrylcholinesterase

multiple interactions

EXP

naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of BCHE protein]; naringin inhibits the reaction [bisphenol A results in increased activity of BCHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of BCHE protein]

PMID:32172062 PMID:32810514

NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

EXP
ISO

[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Oxaliplatin results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Oxaliplatin results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]
naringin results in decreased expression of BCL2 protein
CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Dexamethasone results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]
naringin inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]

PMID:21945202 PMID:28422390 PMID:30130594 PMID:30878453 PMID:35166444 More...

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

bone gamma-carboxyglutamate protein

increases expression
increases secretion
multiple interactions

ISO
EXP

naringin results in increased expression of BGLAP mRNA; naringin results in increased expression of BGLAP protein
naringin results in increased secretion of BGLAP protein
fulvestrant inhibits the reaction [naringin results in increased secretion of BGLAP protein]

PMID:18495116 PMID:21741227 PMID:23596885

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

BH3 interacting domain death agonist

increases expression

ISO

naringin results in increased expression of BID protein

NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275

G

bone morphogenetic protein 2

multiple interactions
decreases expression
increases secretion
increases expression

ISO
EXP

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]; FOS protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; FOS protein affects the reaction [naringin results in increased expression of BMP2 protein]; JUN protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; JUN protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin promotes the reaction [FOS protein binds to BMP2 promoter]; naringin promotes the reaction [JUN protein binds to BMP2 promoter]
naringin results in decreased expression of BMP2 mRNA
fulvestrant inhibits the reaction [naringin results in increased secretion of BMP2 protein]
naringin results in increased expression of BMP2 mRNA; naringin results in increased expression of BMP2 protein

PMID:18495116 PMID:21820093 PMID:23596885

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760

G

bone morphogenetic protein 3

decreases expression

ISO

naringin results in decreased expression of BMP3 mRNA

NCBI chr14:11,012,564...11,041,282
Ensembl chr14:11,016,620...11,041,282

G

bone morphogenetic protein 4

increases expression

ISO

naringin results in increased expression of BMP4 mRNA

NCBI chr15:22,098,191...22,113,145
Ensembl chr15:22,098,470...22,105,172

G

calcitonin receptor

multiple interactions

ISO

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]

NCBI chr 4:32,615,955...32,691,075
Ensembl chr 4:32,615,958...32,691,075

G

caspase 12

increases expression

ISO

naringin results in increased expression of CASP12 protein

NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442

G

caspase 3

increases expression
multiple interactions

ISO
EXP

naringin results in increased expression of CASP3 mRNA
naringin inhibits the reaction [Acetaminophen results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein modified form]; naringin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; naringin inhibits the reaction [Dexamethasone results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of CASP3 protein]
Acetylcysteine inhibits the reaction [naringin results in increased expression of and results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]; naringin results in increased expression of and results in increased cleavage of CASP3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]; naringin inhibits the reaction [Acrylamide results in increased expression of CASP3 protein]; naringin inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of CASP3 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; rottlerin inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]

PMID:21945202 PMID:22847135 PMID:25773745 PMID:26612654 PMID:28422390 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

increases expression
increases cleavage
multiple interactions

ISO
EXP

naringin results in increased expression of CASP9 mRNA
naringin results in increased cleavage of CASP9 protein
[bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP9 protein]; naringin inhibits the reaction [bisphenol A results in increased expression of CASP9 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein]

PMID:22847135 PMID:25773745 PMID:32172062 PMID:32428650 PMID:32810514 More...

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

ISO
EXP

naringin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; naringin inhibits the reaction [Ferric Compounds results in decreased activity of CAT protein]; naringin inhibits the reaction [Nanotubes, Carbon results in decreased activity of CAT protein]
naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased activity of CAT protein]; naringin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; naringin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; naringin inhibits the reaction [Cisplatin results in increased expression of CAT protein]; naringin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; naringin inhibits the reaction [nickel sulfate results in decreased activity of CAT protein]; naringin inhibits the reaction [Oxaliplatin results in decreased activity of CAT protein]

PMID:20950607 PMID:21345335 PMID:21945202 PMID:22198281 PMID:25773745 More...

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO
EXP

naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]
naringin inhibits the reaction [Cyclophosphamide results in increased expression of CCL2 mRNA]

PMID:22965302 PMID:33992719

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

C-C motif chemokine ligand 3

multiple interactions

ISO

naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein]

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439

G

C-C motif chemokine ligand 5

multiple interactions

ISO

naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein]

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884

G

cyclin D1

decreases expression
multiple interactions
increases expression

ISO
EXP

naringin results in decreased expression of CCND1 protein
naringin inhibits the reaction [Dexamethasone results in increased expression of CCND1 mRNA]
Acetylcysteine inhibits the reaction [naringin results in decreased expression of CCND1 protein]; naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CCND1 protein]
naringin results in increased expression of CCND1 mRNA

PMID:18296682 PMID:18951945 PMID:24915843 PMID:26482937 PMID:30878453 More...

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

cyclin E1

decreases expression

ISO
EXP

naringin results in decreased expression of CCNE1 protein

PMID:18296682 PMID:18951945

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

cyclin dependent kinase 2

multiple interactions
decreases expression

EXP
ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in decreased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK2 protein]; naringin results in decreased expression of and results in decreased activity of CDK2 protein; RAF1 protein affects the reaction [naringin results in decreased expression of CDK2 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDK2 protein]; Acetylcysteine inhibits the reaction [naringin results in decreased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; naringin results in decreased expression of and results in decreased activity of CDK2 protein

PMID:18296682 PMID:18951945 PMID:39056589

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878

G

cyclin-dependent kinase 4

multiple interactions

ISO
EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; naringin results in decreased expression of and results in decreased activity of CDK4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in decreased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; naringin results in decreased expression of and results in decreased activity of CDK4 protein; RAF1 protein affects the reaction [naringin results in decreased expression of CDK4 protein]

PMID:18296682 PMID:18951945

NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

ISO
EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]
naringin results in increased expression of CDKN1A mRNA; naringin results in increased expression of CDKN1A protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; naringin promotes the reaction [CDKN1A protein binds to CDK2 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]

PMID:18296682 PMID:18951945 PMID:39056589

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

CF transmembrane conductance regulator

multiple interactions

ISO

naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein]

NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643

G

ChaC glutathione specific gamma-glutamylcyclotransferase 2

multiple interactions

ISO

CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of CHAC2 protein]

PMID:35166444 PMID:35179299

NCBI chr14:108,921,669...108,929,215
Ensembl chr14:108,921,341...108,929,469

G

collagen type I alpha 1 chain

increases expression

ISO

naringin results in increased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

carnitine palmitoyltransferase 1A

multiple interactions

ISO

[Dietary Fats co-treated with naringin] results in decreased expression of CPT1A mRNA

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

colony stimulating factor 1 receptor

multiple interactions

ISO

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]

NCBI chr18:56,834,152...56,860,804
Ensembl chr18:56,817,049...56,860,806

G

catenin beta 1

increases expression
multiple interactions

ISO

naringin results in increased expression of CTNNB1 mRNA
naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CTNNB1 protein]

PMID:24915843 PMID:26482937

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin B

multiple interactions

EXP

naringin inhibits the reaction [Isoproterenol results in decreased activity of CTSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]

NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478

G

cathepsin D

multiple interactions

EXP

naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]

NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:206,956,944...206,968,821

G

cathepsin K

multiple interactions
decreases expression

ISO

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]
naringin results in decreased expression of CTSK mRNA

PMID:21835177 PMID:24376342

NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582

G

C-X-C motif chemokine ligand 12

increases expression

EXP

naringin results in increased expression of CXCL12 protein

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627

G

C-X-C motif chemokine ligand 2

affects expression

ISO

naringin affects the expression of CXCL2 mRNA

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,465,242...17,467,255

G

C-X-C motif chemokine receptor 4

increases expression

EXP

naringin results in increased expression of CXCR4 protein

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

cytochrome b-245 alpha chain

multiple interactions

ISO

naringin inhibits the reaction [TNF protein results in increased expression of CYBA mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA protein]

NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214

G

cytochrome c, somatic

multiple interactions
increases expression

ISO

Acetylcysteine inhibits the reaction [naringin results in decreased expression of CYCS protein]; naringin inhibits the reaction [Cadmium Chloride results in increased expression of CYCS protein]
naringin results in increased expression of CYCS protein

PMID:28422390 PMID:39056589

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816

G

cytochrome P450, family 11, subfamily b, polypeptide 3

multiple interactions

ISO

naringin inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA]

NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:108,689,165...108,694,921

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

EXP

naringin inhibits the reaction [Acrylamide results in decreased expression of CYP17A1 mRNA]

NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

ISO

naringin results in decreased activity of CYP1A1 protein

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

ISO

naringin results in decreased activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

ISO

naringin binds to and results in decreased activity of CYP1B1 protein

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
multiple interactions

ISO

naringin results in decreased activity of CYP3A4 protein
naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil]

PMID:16013069 PMID:21053930

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

DNA-damage inducible transcript 3

increases expression

ISO

naringin results in increased expression of DDIT3 protein

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

dihydrofolate reductase

decreases activity

ISO

naringin results in decreased activity of DHFR protein

NCBI chr 2:25,320,895...25,346,004

G

dickkopf WNT signaling pathway inhibitor 1

multiple interactions

ISO

DKK1 protein inhibits the reaction [naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]]

NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:237,794,969...237,798,650

G

epidermal growth factor

multiple interactions

ISO

naringin inhibits the reaction [EGF protein affects the localization of RELA protein]; naringin inhibits the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]; naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:220,893,660...220,976,297

G

epidermal growth factor receptor

multiple interactions

ISO

naringin inhibits the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:95,378,626...95,551,358

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

EXP

naringin inhibits the reaction [Oxaliplatin results in increased expression of EIF2AK3 mRNA]

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268

G

endonuclease G

increases expression

ISO

naringin results in increased expression of ENDOG protein

NCBI chr 3:33,846,935...33,849,531
Ensembl chr 3:33,846,885...33,849,573

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
increases expression

EXP
ISO

naringin inhibits the reaction [Oxaliplatin results in increased expression of ERN1 mRNA]
naringin results in increased expression of ERN1 protein

PMID:38037725 PMID:39056589

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791

G

estrogen receptor 1

multiple interactions
increases expression

EXP

fulvestrant inhibits the reaction [naringin results in increased expression of ESR1 mRNA]

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

multiple interactions
increases expression

EXP

fulvestrant inhibits the reaction [naringin results in increased expression of ESR2 mRNA]

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

fatty acid binding protein 4

multiple interactions

ISO

naringin inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA]

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:93,488,271...93,492,972

G

Fas associated via death domain

increases expression

ISO

naringin results in increased expression of FADD mRNA

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:209,169,318...209,174,976

G

Fas cell surface death receptor

increases expression

ISO

naringin results in increased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

fatty acid synthase

multiple interactions

ISO

naringin affects the reaction [LEPR protein affects the activity of FASN protein]; naringin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]

PMID:16427799 PMID:22198281

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

fibroblast growth factor 2

multiple interactions
increases expression

EXP

fulvestrant inhibits the reaction [naringin results in increased expression of FGF2 mRNA]

NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]; FOS protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; FOS protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin promotes the reaction [FOS protein binds to BMP2 promoter]
naringin results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598

G

follicle stimulating hormone subunit beta

multiple interactions

EXP

naringin inhibits the reaction [Acrylamide results in decreased expression of FSHB protein]

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

ISO

naringin affects the reaction [LEPR protein affects the expression of G6PC1 mRNA]; naringin inhibits the reaction [Dietary Fats results in increased expression of G6PC1 mRNA]

PMID:16427799 PMID:22198281

NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,757,899...86,818,033

G

glucose-6-phosphate dehydrogenase

multiple interactions

EXP
ISO

naringin inhibits the reaction [nickel sulfate results in decreased activity of G6PD protein]
naringin affects the reaction [LEPR protein affects the activity of G6PD protein]

PMID:16427799 PMID:20950607

NCBI chr X:157,352,364...157,372,144
Ensembl chr X:157,352,373...157,372,144

G

galanin and GMAP prepropeptide

multiple interactions

EXP

naringin inhibits the reaction [Isoproterenol results in increased activity of GAL protein]

NCBI chr 1:210,079,709...210,084,572
Ensembl chr 1:210,079,702...210,084,229

G

glucokinase

multiple interactions

ISO

naringin affects the reaction [LEPR protein affects the expression of GCK mRNA]

NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]; [naringin co-treated with 3-nitropropionic acid] results in increased expression of GCLC mRNA; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC protein]; rottlerin inhibits the reaction [naringin results in increased expression of GCLC protein]
naringin results in increased expression of GCLC mRNA; naringin results in increased expression of GCLC protein

PMID:22871521 PMID:25773745

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamic-oxaloacetic transaminase 1

multiple interactions

ISO

naringin inhibits the reaction [Acetaminophen results in increased secretion of GOT1 protein]

NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871

G

glutamic--pyruvic transaminase

multiple interactions

EXP
ISO

naringin affects the reaction [Cyclophosphamide affects the activity of GPT protein]; naringin inhibits the reaction [Oxaliplatin results in increased activity of GPT protein]; naringin inhibits the reaction [sodium arsenite results in increased expression of GPT protein]
naringin inhibits the reaction [Acetaminophen results in increased secretion of GPT protein]; naringin inhibits the reaction [Doxorubicin results in increased expression of GPT protein]

PMID:27174133 PMID:33992719 PMID:35166444 PMID:36811345 PMID:38037725

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

increases activity

ISO

naringin results in increased activity of GPX1 protein

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

glutathione-disulfide reductase

multiple interactions

EXP
ISO

naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; naringin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]; naringin inhibits the reaction [nickel sulfate results in decreased activity of GSR protein]
naringin inhibits the reaction [Mercuric Chloride results in decreased activity of GSR protein]

PMID:20950607 PMID:21945202 PMID:23650045 PMID:33992719

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

glutathione S-transferase pi 1

increases expression
multiple interactions

EXP

naringin results in increased expression of GSTP1 mRNA
[naringin co-treated with 3-nitropropionic acid] results in increased expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:210,767,237...210,769,705

G

glucuronidase, beta

multiple interactions

EXP

naringin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr12:32,337,281...32,350,838
Ensembl chr12:32,334,075...32,363,024

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

EXP
ISO

naringin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]
naringin affects the reaction [LEPR protein affects the activity of HMGCR protein]

PMID:16427799 PMID:16906524

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

heme oxygenase 1

multiple interactions
increases expression
increases activity

ISO
EXP

CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; naringin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]; naringin inhibits the reaction [Paraquat results in decreased expression of HMOX1 mRNA]; naringin inhibits the reaction [Paraquat results in decreased expression of HMOX1 protein]; naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]
naringin results in increased expression of HMOX1 mRNA; naringin results in increased expression of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of HMOX1 protein]; [naringin co-treated with 3-nitropropionic acid] results in increased expression of HMOX1 mRNA; naringin inhibits the reaction [Oxaliplatin results in decreased expression of HMOX1 mRNA]; naringin inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 mRNA]; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [naringin results in increased expression of HMOX1 protein]
naringin results in increased activity of HMOX1 protein

PMID:22871521 PMID:23603004 PMID:25773745 PMID:27174133 PMID:35166444 More...

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

HRas proto-oncogene, GTPase

multiple interactions
increases activity

ISO
EXP

HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in increased activity of HRAS protein

PMID:18296682 PMID:18951945

NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:205,725,975...205,729,590

G

heat shock protein family A (Hsp70) member 5

multiple interactions
increases expression

EXP
ISO

naringin inhibits the reaction [Oxaliplatin results in increased expression of HSPA5 mRNA]
naringin results in increased expression of HSPA5 protein

PMID:38037725 PMID:39056589

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790

G

intercellular adhesion molecule 1

multiple interactions
affects expression

ISO

naringin inhibits the reaction [Glucose results in increased expression of ICAM1]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
naringin inhibits the reaction [Acetaminophen results in increased expression of ICAM1 mRNA]
naringin affects the expression of ICAM1 mRNA

PMID:22074828 PMID:25117567 PMID:25391245 PMID:35166444 PMID:35179299

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617

G

interferon, alpha 1

multiple interactions

EXP

naringin inhibits the reaction [Cyclophosphamide results in increased expression of IFNA1 mRNA]

NCBI chr 5:108,143,240...108,143,809
Ensembl chr 5:108,143,240...108,143,809

G

interferon gamma

multiple interactions
affects expression

ISO

naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein]
naringin affects the expression of IFNG mRNA

PMID:16945185 PMID:21500970

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

insulin-like growth factor 1

affects expression
multiple interactions
increases expression

EXP
ISO

naringin affects the expression of IGF1 mRNA
naringin inhibits the reaction [Dexamethasone results in increased expression of IGF1 mRNA]
naringin results in increased expression of IGF1 mRNA
fulvestrant inhibits the reaction [naringin results in increased expression of IGF1 mRNA]

PMID:23596885 PMID:24880026 PMID:30878453

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

interleukin 10

multiple interactions
affects expression

EXP
ISO

naringin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of IL10 protein]
naringin affects the expression of IL10 protein

PMID:22985397 PMID:25117567

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

affects expression
multiple interactions

EXP
ISO

naringin affects the expression of IL1B mRNA
[bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of IL1B protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein]; naringin inhibits the reaction [Acrylamide results in increased expression of IL1B protein]; naringin inhibits the reaction [bisphenol A results in increased expression of IL1B protein]; naringin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; naringin inhibits the reaction [Oxaliplatin results in increased expression of IL1B mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B protein]
naringin inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; naringin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]

PMID:24131540 PMID:24880026 PMID:30130594 PMID:32172062 PMID:32428650 More...

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 1 receptor type 1

multiple interactions

EXP

naringin inhibits the reaction [Cyclophosphamide results in increased expression of IL1R1 mRNA]

NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:50,000,566...50,076,579

G

interleukin 2

affects expression

ISO

naringin affects the expression of IL2 protein

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672

G

interleukin 4

affects expression

ISO

naringin affects the expression of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

affects expression
multiple interactions
decreases expression

EXP
ISO

naringin affects the expression of IL6 mRNA
[naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Acrylamide results in increased expression of IL6 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; naringin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
naringin results in decreased expression of IL6 protein
naringin affects the expression of IL6 protein
naringin inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 protein]

PMID:16137700 PMID:19810018 PMID:21820093 PMID:24131540 PMID:24880026 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

insulin 1

multiple interactions
affects expression

ISO
EXP

naringin inhibits the reaction [Nanotubes, Carbon inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; naringin promotes the reaction [Glucose results in increased secretion of INS1 protein]
naringin affects the expression of INS1 protein

PMID:24880026 PMID:29658312

NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682

G

insulin receptor substrate 1

multiple interactions

ISO

naringin inhibits the reaction [Dietary Fats results in decreased phosphorylation of IRS1 protein]

NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; JUN protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; JUN protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]; naringin promotes the reaction [JUN protein binds to BMP2 promoter]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]
naringin results in increased expression of JUN mRNA

PMID:18495116 PMID:35166444

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

Kelch-like ECH-associated protein 1

multiple interactions

ISO

naringin inhibits the reaction [Doxorubicin results in decreased expression of KEAP1 protein]

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042

G

lecithin cholesterol acyltransferase

multiple interactions

EXP

naringin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]

NCBI chr19:50,744,598...50,748,064
Ensembl chr19:50,744,601...50,748,081

G

lactate dehydrogenase A

multiple interactions

EXP

naringin inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521

G

lactate dehydrogenase B

multiple interactions

EXP

naringin inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]

NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:177,159,392...177,177,408

G

leptin

multiple interactions

ISO
EXP

naringin inhibits the reaction [Dietary Fats results in increased expression of LEP protein]
[naringin co-treated with Hesperidin] results in decreased expression of LEP protein; naringin inhibits the reaction [Glucose results in increased expression of LEP protein]

PMID:21820093 PMID:22198281 PMID:24399619

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661

G

leptin receptor

multiple interactions

ISO
EXP

naringin affects the reaction [LEPR protein affects the abundance of Glucose]; naringin affects the reaction [LEPR protein affects the activity of FASN protein]; naringin affects the reaction [LEPR protein affects the activity of G6PD protein]; naringin affects the reaction [LEPR protein affects the activity of HMGCR protein]; naringin affects the reaction [LEPR protein affects the expression of G6PC1 mRNA]; naringin affects the reaction [LEPR protein affects the expression of GCK mRNA]; naringin affects the reaction [LEPR protein affects the expression of PCK1 mRNA]; naringin affects the reaction [LEPR protein affects the expression of PPARG protein]; naringin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; naringin affects the reaction [LEPR protein affects the expression of SLC2A4 protein]
naringin inhibits the reaction [Glucose results in increased expression of LEPR protein]

PMID:16427799 PMID:24399619

NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215

G

luteinizing hormone subunit beta

multiple interactions

EXP

naringin inhibits the reaction [Acrylamide results in decreased expression of LHB protein]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

lipoprotein lipase

multiple interactions

EXP

naringin inhibits the reaction [Isoproterenol results in decreased activity of LPL protein]

NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107

G

monoamine oxidase A

multiple interactions

EXP

[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of MAOA protein; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of MAOA protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of MAOA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of MAOA protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]

PMID:32172062 PMID:32428650 PMID:32810514

NCBI chr X:8,615,239...8,681,372
Ensembl chr X:8,615,239...8,682,631

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation

ISO
EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]
naringin results in decreased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]
naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]

PMID:18296682 PMID:18951945 PMID:21835177 PMID:22198281 PMID:22766066 More...

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 10

multiple interactions

ISO

naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK10 protein]

NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100

G

mitogen activated protein kinase 14

multiple interactions

EXP

naringin inhibits the reaction [Acrylamide results in increased expression of MAPK14 mRNA]

NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

ISO
EXP

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in decreased phosphorylation of MAPK3 protein
naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]

PMID:18296682 PMID:18951945 PMID:21835177 PMID:22198281 PMID:22766066 More...

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

mitogen-activated protein kinase 8

multiple interactions

ISO

naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427

G

mitogen-activated protein kinase 9

multiple interactions

ISO

naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228

G

microRNA 126a

multiple interactions
increases expression

ISO

MIR126 mRNA affects the reaction [naringin results in decreased expression of VCAM1 mRNA]
naringin results in increased expression of MIR126 mRNA

NCBI chr 3:29,813,150...29,813,267

G

matrix metallopeptidase 2

multiple interactions

ISO

naringin results in decreased expression of and results in decreased activity of MMP2 protein

NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856

G

matrix metallopeptidase 9

multiple interactions

ISO
EXP

naringin inhibits the reaction [Paraquat results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [Paraquat results in increased expression of MMP9 protein]
naringin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; naringin results in decreased expression of and results in decreased activity of MMP9 protein
naringin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; naringin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MMP9 protein]

PMID:19810018 PMID:22985397 PMID:23603004 PMID:25866363 PMID:26721195

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442

G

myeloperoxidase

multiple interactions

EXP

naringin inhibits the reaction [Tobacco Smoke Pollution results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

metallothionein 3

multiple interactions

ISO

naringin inhibits the reaction [Cadmium Chloride results in increased expression of MT3 protein]

NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080

G

mechanistic target of rapamycin kinase

multiple interactions

EXP

naringin inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein]

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

ISO

naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA]; naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]
naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased secretion of MUC5AC protein]

PMID:22766066 PMID:31301536

NCBI chr 1:206,293,717...206,326,006
Ensembl chr 1:206,293,869...206,326,006

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects localization

EXP
ISO

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin affects the localization of NFE2L2 protein]; [naringin co-treated with 3-nitropropionic acid] affects the localization of NFE2L2 protein; naringin inhibits the reaction [Oxaliplatin results in decreased expression of NFE2L2 mRNA]; naringin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] affects the localization of NFE2L2 protein]; rottlerin inhibits the reaction [naringin affects the localization of NFE2L2 protein]
CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]; naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]

PMID:22871521 PMID:25773745 PMID:27174133 PMID:35166444 PMID:35179299 More...

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

nuclear factor kappa B subunit 1

multiple interactions

EXP

naringin inhibits the reaction [Cisplatin results in increased expression of NFKB1 mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of NFKB1 mRNA]

PMID:26120027 PMID:26612654 PMID:38037725

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088

G

NFKB inhibitor alpha

affects degradation
multiple interactions

ISO

naringin affects the degradation of NFKBIA protein
naringin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]

PMID:21835177 PMID:25117567

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

affects expression
multiple interactions

ISO
EXP

naringin affects the expression of NOS2 mRNA
naringin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]; naringin inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]; naringin inhibits the reaction [Oxaliplatin results in increased expression of NOS2 mRNA]

PMID:16137700 PMID:22871521 PMID:25117567 PMID:26612654 PMID:38037725

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NADPH oxidase 4

multiple interactions

ISO

naringin inhibits the reaction [TNF protein results in increased expression of NOX4 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 protein]

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

EXP

[naringin co-treated with 3-nitropropionic acid] results in increased expression of NQO1 mRNA
naringin results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

naringin results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

ISO

naringin affects the reaction [LEPR protein affects the expression of PCK1 mRNA]

NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561

G

phosphodiesterase 5A

multiple interactions

EXP

naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein]; naringin inhibits the reaction [[potassium bromate co-treated with Caffeine] results in increased activity of PDE5A protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of PDE5A protein]; naringin inhibits the reaction [Caffeine results in increased activity of PDE5A protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of PDE5A protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]; naringin inhibits the reaction [potassium bromate results in increased activity of PDE5A protein]

PMID:32172062 PMID:32428650 PMID:32810514 PMID:37865952

NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

multiple interactions

ISO

naringin inhibits the reaction [Dexamethasone results in increased expression of PIK3CA mRNA]

NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

ISO

naringin inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA]

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347

G

peroxisome proliferator activated receptor alpha

multiple interactions

ISO

naringin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

peroxisome proliferator-activated receptor gamma

multiple interactions

ISO
EXP

naringin affects the reaction [LEPR protein affects the expression of PPARG protein]; naringin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]

PMID:16427799 PMID:22198281 PMID:30130594

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104

G

PPARG coactivator 1 alpha

multiple interactions

EXP

naringin inhibits the reaction [Ethanol results in increased expression of PPARGC1A mRNA]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

protein kinase C, delta

increases phosphorylation
multiple interactions

EXP

naringin results in increased phosphorylation of PRKCD protein
rottlerin inhibits the reaction [naringin results in increased phosphorylation of PRKCD protein]

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839

G

prostaglandin-endoperoxide synthase 2

affects expression
multiple interactions

ISO
EXP

naringin affects the expression of PTGS2 mRNA; naringin affects the expression of PTGS2 protein
naringin inhibits the reaction [Acetaminophen results in increased expression of PTGS2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of PTGS2 protein]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of PTGS2 mRNA]

PMID:16137700 PMID:22871521 PMID:25117567 PMID:35166444 PMID:35179299 More...

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions
increases activity
increases phosphorylation

ISO
EXP

RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
RAF1 protein affects the reaction [naringin results in decreased expression of CDK2 protein]; RAF1 protein affects the reaction [naringin results in decreased expression of CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in increased activity of RAF1 protein
naringin results in increased phosphorylation of RAF1 protein

PMID:18296682 PMID:18951945

NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [EGF protein affects the localization of RELA protein]
naringin affects the expression of and affects the activity of RELA protein; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]

PMID:21500970 PMID:22766066 PMID:22965302 PMID:25117567

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

ribosomal protein S6 kinase B1

multiple interactions

EXP

naringin inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [Okadaic Acid results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]

PMID:15342961 PMID:19810018

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,815,614...71,865,238

G

RUNX family transcription factor 2

increases expression
multiple interactions

ISO
EXP

naringin results in increased expression of RUNX2 mRNA
naringin inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 protein]
DKK1 protein inhibits the reaction [naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]]; naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]
fulvestrant inhibits the reaction [naringin results in increased expression of RUNX2 mRNA]

PMID:21741227 PMID:23596885 PMID:24915843 PMID:26482937 PMID:30878453

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

sirtuin 1

multiple interactions

EXP
ISO

naringin inhibits the reaction [Ethanol results in increased expression of SIRT1 mRNA]
naringin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]

PMID:18793633 PMID:36811345

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

solute carrier family 2 member 2

multiple interactions

ISO

naringin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]

NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467

G

solute carrier family 2 member 4

multiple interactions

ISO

naringin affects the reaction [LEPR protein affects the expression of SLC2A4 protein]

NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270

G

solute carrier organic anion transporter family, member 1a1

multiple interactions

EXP

naringin inhibits the reaction [SLCO1A1 protein results in increased uptake of perfluorooctanoic acid]

NCBI chr 4:176,606,924...176,682,027
Ensembl chr 4:176,607,687...176,681,992

G

solute carrier organic anion transporter family, member 1a4

multiple interactions

ISO

naringin inhibits the reaction [SLCO1A2 protein alternative form results in increased uptake of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased transport of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quinine]

PMID:24947867 PMID:25466967 PMID:27504015

NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816

G

solute carrier organic anion transporter family member 1B2

multiple interactions

ISO

naringin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea]

PMID:21256917 PMID:22394605

NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083

G

SMAD family member 3

multiple interactions

EXP

naringin inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA]

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

superoxide dismutase 2

multiple interactions

ISO

CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; naringin inhibits the reaction [Ferric Compounds results in decreased activity of SOD2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]

PMID:21345335 PMID:35166444 PMID:35179299 PMID:36811345

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168

G

Sp7 transcription factor

increases expression
multiple interactions

EXP
ISO

naringin results in increased expression of SP7 mRNA
naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP7 mRNA]
fulvestrant inhibits the reaction [naringin results in increased expression of SP7 mRNA]

PMID:23596885 PMID:26482937

NCBI chr 7:135,363,193...135,373,376
Ensembl chr 7:135,363,199...135,373,559

G

sialophorin

multiple interactions
increases expression
decreases expression

EXP

[bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of SPN protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein]; naringin inhibits the reaction [bisphenol A results in increased expression of SPN protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein]
naringin results in increased expression of SPN protein
naringin results in decreased expression of SPN protein

PMID:32172062 PMID:32428650

NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:191,178,096...191,187,852

G

secreted phosphoprotein 1

increases expression
increases secretion
multiple interactions

ISO
EXP

naringin results in increased expression of SPP1 mRNA; naringin results in increased expression of SPP1 protein
naringin results in increased secretion of SPP1 protein
fulvestrant inhibits the reaction [naringin results in increased secretion of SPP1 protein]

PMID:18495116 PMID:23596885 PMID:24915843

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

sterol regulatory element binding transcription factor 1

multiple interactions

ISO

naringin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

steroidogenic acute regulatory protein

multiple interactions

EXP

naringin inhibits the reaction [Acrylamide results in decreased expression of STAR mRNA]

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

signal transducer and activator of transcription 3

affects expression

ISO

naringin affects the expression of STAT3 mRNA; naringin affects the expression of STAT3 protein

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359

G

transforming growth factor, beta 1

multiple interactions
affects expression

ISO
EXP

naringin inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
naringin inhibits the reaction [Cyclophosphamide results in increased expression of TGFB1 mRNA]; naringin inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]
naringin affects the expression of TGFB1 mRNA

PMID:23603004 PMID:25117567 PMID:27174133 PMID:33992719

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899

G

TIMP metallopeptidase inhibitor 1

multiple interactions

ISO

naringin inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; naringin inhibits the reaction [Paraquat results in increased expression of TIMP1 protein]

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:3,766,510...3,771,135

G

tumor necrosis factor

multiple interactions
affects expression

ISO
EXP

naringin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; naringin inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; naringin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]; naringin inhibits the reaction [Paraquat results in increased expression of TNF mRNA]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein]; naringin inhibits the reaction [Acrylamide results in increased expression of TNF protein]; naringin inhibits the reaction [bisphenol A results in increased expression of TNF protein]; naringin inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; naringin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF protein]; naringin inhibits the reaction [Oxaliplatin results in increased expression of TNF mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; naringin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; naringin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]; naringin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF protein]
naringin affects the expression of TNF protein
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA protein]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 protein]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
naringin affects the expression of TNF mRNA

PMID:16137700 PMID:19810018 PMID:21500970 PMID:22198281 PMID:22871521 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 11A

decreases expression

ISO

naringin results in decreased expression of TNFRSF11A mRNA

NCBI chr13:22,442,930...22,501,257
Ensembl chr13:22,442,665...22,501,257

G

TNF receptor superfamily member 11B

multiple interactions

ISO

naringin inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of TNFRSF11B protein]

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:87,456,319...87,485,075

G

TNF superfamily member 11

multiple interactions

ISO

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]; naringin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

troponin T2, cardiac type

multiple interactions

EXP

naringin inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]

NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125

G

tumor protein p53

increases expression
multiple interactions
decreases expression

ISO
EXP

naringin results in increased expression of TP53 mRNA
naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]
naringin results in decreased expression of TP53 protein
[bisphenol A co-treated with naringin] results in decreased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of TP53 protein; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein]; naringin inhibits the reaction [Acrylamide results in increased expression of TP53 mRNA]; naringin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; naringin inhibits the reaction [Cisplatin results in increased expression of TP53 mRNA]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]

PMID:22847135 PMID:26120027 PMID:26612654 PMID:32172062 PMID:32428650 More...

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

thymic stromal lymphopoietin

multiple interactions

ISO

naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP protein]

NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,720,257...24,728,420

G

uncoupling protein 2

multiple interactions

ISO

naringin inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743

G

vascular cell adhesion molecule 1

multiple interactions
decreases expression

ISO

MIR126 mRNA affects the reaction [naringin results in decreased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
naringin results in decreased expression of VCAM1 mRNA; naringin results in decreased expression of VCAM1 protein

PMID:24975661 PMID:25391245

NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801

G

vascular endothelial growth factor C

affects expression

EXP

naringin affects the expression of VEGFC mRNA

NCBI chr16:44,445,293...44,560,887
Ensembl chr16:44,445,293...44,560,887

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1, member C1

multiple interactions

ISO

[astilbin co-treated with Cisplatin] results in increased expression of AKR1C1 mRNA

NCBI chr17:70,720,397...70,747,285
Ensembl chr17:70,720,398...70,747,247

G

AKT serine/threonine kinase 1

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610

G

BCL2 associated X, apoptosis regulator

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased expression of BAX protein]

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

BCL2, apoptosis regulator

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

caspase 3

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 9

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in decreased expression of GCLC mRNA]

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:87,510,463...87,548,893

G

glutamate cysteine ligase, modifier subunit

multiple interactions

ISO

astilbin promotes the reaction [Cisplatin results in increased expression of GCLM mRNA]

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:213,031,838...213,055,003

G

interleukin 1 beta

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased expression of IL6 protein]

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

mitogen activated protein kinase 1

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

astilbin promotes the reaction [Cisplatin affects the localization of NFE2L2 protein]
astilbin promotes the reaction [Cisplatin results in increased expression of NFE2L2 protein]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

nitric oxide synthase 2

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

astilbin promotes the reaction [Cisplatin results in increased expression of NQO1 mRNA]

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260

G

poly (ADP-ribose) polymerase 1

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased cleavage of PARP1 protein]

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

tumor necrosis factor

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased expression of TNF protein]
astilbin promotes the reaction [Cisplatin results in increased expression of TNF mRNA]

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

tumor protein p53

multiple interactions

ISO

astilbin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bone gamma-carboxyglutamate protein

multiple interactions
increases expression

ISO

neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA]
neoeriocitrin results in increased expression of BGLAP mRNA

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

collagen type I alpha 1 chain

multiple interactions
increases expression

ISO

neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of COL1A1 mRNA]
neoeriocitrin results in increased expression of COL1A1 mRNA

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460

G

RUNX family transcription factor 2

increases expression

ISO

neoeriocitrin results in increased expression of RUNX2 mRNA

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA acyltransferase 2

multiple interactions

ISO

[neohesperidin co-treated with Dietary Fats] results in increased expression of ACAA2 mRNA

NCBI chr18:70,620,310...70,648,417
Ensembl chr18:70,620,110...70,648,420

G

acetyl-CoA carboxylase alpha

multiple interactions

ISO

neohesperidin inhibits the reaction [Dietary Fats results in increased expression of ACACA mRNA]

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,511,857...69,773,888

G

acyl-CoA oxidase 1

multiple interactions

ISO

neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,905,083...101,930,136

G

acid phosphatase 5, tartrate resistant

decreases expression

ISO

neohesperidin results in decreased expression of ACP5 mRNA

NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929

G

angiotensinogen

multiple interactions

EXP
ISO

neohesperidin inhibits the reaction [AGT protein results in increased expression of MAPK1 protein]; neohesperidin inhibits the reaction [AGT protein results in increased expression of MAPK3 protein]; neohesperidin inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]
neohesperidin inhibits the reaction [AGT protein results in increased expression of MAPK1 protein]; neohesperidin inhibits the reaction [AGT protein results in increased expression of MAPK3 protein]; neohesperidin inhibits the reaction [AGT protein results in increased expression of MYH7 mRNA]; neohesperidin inhibits the reaction [AGT protein results in increased expression of NOX4 mRNA]; neohesperidin inhibits the reaction [AGT protein results in increased expression of NPPA mRNA]; neohesperidin inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]

NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944

G

agouti signaling protein

multiple interactions

ISO

neohesperidin inhibits the reaction [A mutant form results in increased expression of SCD1 mRNA]

NCBI chr 3:163,933,768...164,021,377
Ensembl chr 3:164,015,903...164,021,378

G

bone gamma-carboxyglutamate protein

multiple interactions
increases expression

ISO

DKK1 protein inhibits the reaction [neohesperidin results in increased expression of BGLAP mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of BGLAP mRNA]
SNHG1 protein inhibits the reaction [neohesperidin results in increased expression of BGLAP mRNA]; SNHG1 protein inhibits the reaction [neohesperidin results in increased expression of BGLAP protein]
neohesperidin results in increased expression of BGLAP mRNA; neohesperidin results in increased expression of BGLAP protein

PMID:34020675 PMID:34455928 PMID:34919014

NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318

G

bone morphogenetic protein 2

increases expression
multiple interactions
decreases methylation

ISO

neohesperidin results in increased expression of BMP2 mRNA; neohesperidin results in increased expression of BMP2 protein
DKK1 protein inhibits the reaction [neohesperidin results in increased expression of BMP2 mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of BMP2 mRNA]
neohesperidin results in decreased methylation of BMP2 promoter

PMID:34020675 PMID:34919014 PMID:39067325

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:141,264,646...141,274,760

G

catalase

multiple interactions

ISO

neohesperidin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of CAT mRNA]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

C-C motif chemokine ligand 2

multiple interactions

ISO

neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of CCL2 mRNA]

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875

G

cyclin D1

increases expression

ISO

neohesperidin results in increased expression of CCND1 mRNA; neohesperidin results in increased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810

G

carnitine palmitoyltransferase 1A

multiple interactions

ISO

neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of CPT1A mRNA]

PMID:28554169 PMID:32759940

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:209,993,875...210,056,326

G

catenin beta 1

multiple interactions
increases expression
affects localization

ISO

DKK1 protein inhibits the reaction [neohesperidin results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of CTNNB1 mRNA]; neohesperidin results in increased expression of and results in decreased phosphorylation of CTNNB1 protein; XAV939 inhibits the reaction [neohesperidin results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]
neohesperidin affects the localization of CTNNB1 protein

PMID:34020675 PMID:34919014 PMID:39067325

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

cathepsin K

decreases expression

ISO

neohesperidin results in decreased expression of CTSK mRNA

NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:185,747,165...185,765,582

G

dickkopf WNT signaling pathway inhibitor 1

multiple interactions

ISO

DKK1 protein inhibits the reaction [neohesperidin results in increased expression of BGLAP mRNA]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of BMP2 mRNA]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of DLX5 mRNA]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of RUNX2 mRNA]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of SPP1 mRNA]
DKK1 protein inhibits the reaction [neohesperidin results in increased expression of and results in decreased phosphorylation of CTNNB1 protein]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of CTNNB1 mRNA]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of LEF1 mRNA]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of MYC mRNA]; DKK1 protein inhibits the reaction [neohesperidin results in increased expression of TCF7 mRNA]

PMID:34020675 PMID:34919014

NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:237,794,969...237,798,650

G

distal-less homeobox 5

multiple interactions
increases expression

ISO

DKK1 protein inhibits the reaction [neohesperidin results in increased expression of DLX5 mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of DLX5 mRNA]

NCBI chr 4:35,965,579...35,969,973
Ensembl chr 4:35,965,579...35,969,845

G

fatty acid synthase

multiple interactions

ISO

neohesperidin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]
neohesperidin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of FASN mRNA]

PMID:28554169 PMID:32759940

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583

G

fibroblast growth factor 21

increases expression
multiple interactions

ISO

neohesperidin results in increased expression of FGF21 mRNA
neohesperidin promotes the reaction [Dietary Fats results in increased expression of FGF21 protein]

NCBI chr 1:105,219,825...105,221,376
Ensembl chr 1:105,219,825...105,232,056

G

glial fibrillary acidic protein

affects expression

EXP

neohesperidin affects the expression of GFAP protein

NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685

G

glutamic--pyruvic transaminase

multiple interactions

ISO

neohesperidin inhibits the reaction [Dietary Fats results in increased expression of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

glutathione peroxidase 1

multiple interactions

ISO

neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of GPX1 mRNA]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

ISO

neohesperidin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of HMGCR mRNA]

NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533

G

interferon gamma

multiple interactions
decreases secretion

EXP

Anisomycin inhibits the reaction [neohesperidin results in decreased secretion of IFNG protein]

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216

G

interleukin 1 alpha

multiple interactions

ISO

[Ascorbic Acid co-treated with neohesperidin co-treated with pycnogenols co-treated with Tocopherols co-treated with Hyaluronic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Vehicle Emissions] which results in increased expression of IL1A mRNA]

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013

G

interleukin 1 beta

affects expression
multiple interactions

EXP
ISO

neohesperidin affects the expression of IL1B protein
neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1B mRNA]; neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL1B protein]; neohesperidin inhibits the reaction [Dietary Fats results in increased expression of IL1B mRNA]

PMID:32759940 PMID:36331667 PMID:39547268

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 27

multiple interactions
decreases secretion

EXP

Anisomycin inhibits the reaction [neohesperidin results in increased secretion of IL27 protein]
neohesperidin results in decreased secretion of IL27 protein

NCBI chr 1:190,603,684...190,609,292
Ensembl chr 1:190,603,522...190,609,258

G

interleukin 4

multiple interactions
decreases secretion

EXP

Anisomycin inhibits the reaction [neohesperidin results in increased secretion of IL4 protein]
neohesperidin results in decreased secretion of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 6

multiple interactions
decreases secretion

ISO
EXP

[Ascorbic Acid co-treated with neohesperidin co-treated with pycnogenols co-treated with Tocopherols co-treated with Hyaluronic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Vehicle Emissions] which results in increased expression of IL6 mRNA]
neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 mRNA]; neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of IL6 protein]; neohesperidin inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA]
Anisomycin inhibits the reaction [neohesperidin results in decreased secretion of IL6 protein]

PMID:32759940 PMID:33604646 PMID:35150043 PMID:39547268

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

interferon regulatory factor 5

affects expression

EXP

neohesperidin affects the expression of IRF5 protein

NCBI chr 4:59,092,914...59,104,596
Ensembl chr 4:59,081,357...59,112,552

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

ISO

neohesperidin results in increased expression of JUN mRNA; neohesperidin results in increased expression of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285

G

lymphoid enhancer binding factor 1

increases expression
multiple interactions

ISO

neohesperidin results in increased expression of LEF1 mRNA; neohesperidin results in increased expression of LEF1 protein
DKK1 protein inhibits the reaction [neohesperidin results in increased expression of LEF1 mRNA]

PMID:34020675 PMID:34919014

NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929

G

mitogen activated protein kinase 1

multiple interactions
affects phosphorylation

ISO
EXP

neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of MAPK1 protein]; neohesperidin inhibits the reaction [AGT protein results in increased expression of MAPK1 protein]
neohesperidin affects the phosphorylation of MAPK1 protein

PMID:32531678 PMID:36331667 PMID:39547268

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions
affects phosphorylation

ISO
EXP

neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of MAPK3 protein]; neohesperidin inhibits the reaction [AGT protein results in increased expression of MAPK3 protein]
neohesperidin affects the phosphorylation of MAPK3 protein

PMID:32531678 PMID:36331667 PMID:39547268

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

myeloperoxidase

multiple interactions

ISO

neohesperidin inhibits the reaction [Dietary Fats results in increased expression of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions
increases expression

ISO

DKK1 protein inhibits the reaction [neohesperidin results in increased expression of MYC mRNA]
neohesperidin results in increased expression of MYC mRNA; neohesperidin results in increased expression of MYC protein

PMID:34020675 PMID:34919014

NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028

G

myosin heavy chain 7

multiple interactions

ISO

neohesperidin inhibits the reaction [AGT protein results in increased expression of MYH7 mRNA]

NCBI chr15:32,416,525...32,439,851
Ensembl chr15:32,416,527...32,438,194

G

nuclear factor of activated T-cells 1

multiple interactions

ISO

neohesperidin inhibits the reaction [TNFSF11 protein results in increased expression of and results in increased activity of NFATC1 protein]

NCBI chr18:76,321,386...76,430,997
Ensembl chr18:76,321,386...76,430,990

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of NFE2L2 mRNA]
neohesperidin inhibits the reaction [Palmitic Acid results in decreased expression of NFE2L2 mRNA]; SR18292 inhibits the reaction [neohesperidin inhibits the reaction [Palmitic Acid results in decreased expression of NFE2L2 mRNA]]

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090

G

NFKB inhibitor alpha

multiple interactions

ISO

neohesperidin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]

NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072

G

noggin

multiple interactions

ISO

NOG protein inhibits the reaction [neohesperidin results in increased expression of BGLAP mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of BMP2 mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of DLX5 mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of RUNX2 mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of SPP1 mRNA]

NCBI chr10:74,625,874...74,627,501
Ensembl chr10:74,625,875...74,628,103

G

NADPH oxidase 4

multiple interactions

ISO

neohesperidin inhibits the reaction [AGT protein results in increased expression of NOX4 mRNA]

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:150,313,728...150,491,483

G

natriuretic peptide A

multiple interactions

ISO

neohesperidin inhibits the reaction [AGT protein results in increased expression of NPPA mRNA]

NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493

G

natriuretic peptide B

multiple interactions

ISO
EXP

neohesperidin inhibits the reaction [AGT protein results in increased expression of NPPB mRNA]

NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:163,699,839...163,701,310

G

purinergic receptor P2X 4

affects expression

EXP

neohesperidin affects the expression of P2RX4 mRNA; neohesperidin affects the expression of P2RX4 protein

NCBI chr12:39,505,438...39,523,349
Ensembl chr12:39,505,438...39,523,094

G

pyruvate dehydrogenase kinase 4

multiple interactions

ISO

neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of PDK4 mRNA]

NCBI chr 4:34,558,327...34,568,329
Ensembl chr 4:34,556,330...34,568,381

G

peroxisome proliferator activated receptor alpha

multiple interactions
increases expression

ISO

neohesperidin inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of PPARA protein]
neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]; neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]
neohesperidin results in increased expression of PPARA mRNA

PMID:28554169 PMID:32759940

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

PPARG coactivator 1 alpha

multiple interactions

ISO

[neohesperidin co-treated with Dietary Fats] results in increased expression of PPARGC1A protein; neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of PPARGC1A mRNA]

NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ISO

neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 mRNA]; neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases phosphorylation

ISO
EXP

neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased phosphorylation of RELA protein]
neohesperidin results in decreased phosphorylation of RELA protein

PMID:33604646 PMID:39547268

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817

G

RUNX family transcription factor 2

multiple interactions
increases expression

ISO

SNHG1 protein inhibits the reaction [neohesperidin results in increased expression of RUNX2 mRNA]; SNHG1 protein inhibits the reaction [neohesperidin results in increased expression of RUNX2 protein]
neohesperidin results in increased expression of RUNX2 mRNA; neohesperidin results in increased expression of RUNX2 protein
DKK1 protein inhibits the reaction [neohesperidin results in increased expression of RUNX2 mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of RUNX2 mRNA]

PMID:34020675 PMID:34455928 PMID:34919014 PMID:39067325

NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:23,664,952...23,990,027

G

stearoyl-CoA desaturase

multiple interactions

ISO

neohesperidin inhibits the reaction [A mutant form results in increased expression of SCD1 mRNA]; neohesperidin inhibits the reaction [Dietary Fats results in increased expression of SCD1 mRNA]

PMID:25620042 PMID:32759940

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:253,218,970...253,231,785

G

sirtuin 1

increases expression

ISO

neohesperidin results in increased expression of SIRT1 protein

NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,305,476...25,328,000

G

superoxide dismutase 1

multiple interactions

ISO

neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of SOD1 mRNA]

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399

G

secreted phosphoprotein 1

increases expression
multiple interactions

ISO

neohesperidin results in increased expression of SPP1 mRNA
DKK1 protein inhibits the reaction [neohesperidin results in increased expression of SPP1 mRNA]; NOG protein inhibits the reaction [neohesperidin results in increased expression of SPP1 mRNA]

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820

G

sterol regulatory element binding transcription factor 1

multiple interactions

ISO

neohesperidin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SREBF1 mRNA]
neohesperidin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]

PMID:28554169 PMID:32759940

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164

G

transcription factor 7

multiple interactions
increases expression

ISO

DKK1 protein inhibits the reaction [neohesperidin results in increased expression of TCF7 mRNA]
neohesperidin results in increased expression of TCF7 mRNA; neohesperidin results in increased expression of TCF7 protein

PMID:34020675 PMID:34919014

NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,924,363...36,954,279

G

transcription factor A, mitochondrial

multiple interactions

ISO

neohesperidin inhibits the reaction [Palmitic Acid results in decreased expression of TFAM mRNA]; SR18292 inhibits the reaction [neohesperidin inhibits the reaction [Palmitic Acid results in decreased expression of TFAM mRNA]]
neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of TFAM mRNA]

NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,355,363...17,369,877

G

tumor necrosis factor

decreases secretion
multiple interactions

EXP
ISO

neohesperidin results in decreased secretion of TNF protein
neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TNF mRNA]; neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of TNF protein]; neohesperidin inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]
[Ascorbic Acid co-treated with neohesperidin co-treated with pycnogenols co-treated with Tocopherols co-treated with Hyaluronic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Vehicle Emissions] which results in increased expression of TNF mRNA]
Anisomycin inhibits the reaction [neohesperidin results in decreased secretion of TNF protein]

PMID:32759940 PMID:33604646 PMID:35150043 PMID:39547268

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 1A

affects expression

EXP

neohesperidin affects the expression of TNFRSF1A protein

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816

G

TNF superfamily member 11

multiple interactions

ISO

neohesperidin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]; neohesperidin inhibits the reaction [TNFSF11 protein results in increased expression of and results in increased activity of NFATC1 protein]

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479

G

uncoupling protein 2

multiple interactions

ISO

neohesperidin inhibits the reaction [Dietary Fats results in decreased expression of UCP2 mRNA]

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:164,251,373...164,257,743

G

vascular endothelial growth factor A

multiple interactions

ISO

neohesperidin inhibits the reaction [[Azoxymethane co-treated with Dextran Sulfate] results in increased expression of VEGFA protein]

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

ISO

pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]; pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR protein]

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

ISO

pinocembrin results in decreased activity of CYP19A1 protein

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

ISO

pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

ISO

pinocembrin results in decreased activity of CYP1A2 protein

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects activity

ISO

pinocembrin affects the activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

glutamic--pyruvic transaminase

multiple interactions

ISO

pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased activity of GPT protein]

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160

G

H2A.X variant histone

multiple interactions

ISO

pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein]

NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079

G

mitogen activated protein kinase 1

multiple interactions

ISO

pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]; pinocembrin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK1 protein]]

PMID:18295389 PMID:33393179

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825

G

mitogen activated protein kinase 3

multiple interactions

ISO

pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]; pinocembrin inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK3 protein]]

PMID:18295389 PMID:33393179

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions

ISO

pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of SRC protein]; pinocembrin promotes the reaction [Dasatinib inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of SRC protein]]

NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462

G

sulfotransferase family 1A member 1

increases sulfation

ISO
EXP

SULT1A1 protein results in increased sulfation of pinocembrin

NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131

G

transglutaminase 2

multiple interactions

ISO

pinocembrin inhibits the reaction [Ethanol results in increased activity of TGM2 protein]; pinocembrin inhibits the reaction [Ethanol results in increased expression of TGM2 mRNA]

NCBI chr 3:167,192,612...167,221,845
Ensembl chr 3:167,192,612...167,304,240

G

tumor protein p53 binding protein 1

multiple interactions

ISO

pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of TP53BP1 protein]
pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased expression of TRP53BP1 protein]

NCBI chr 3:128,620,320...128,724,716
Ensembl chr 3:128,620,322...128,696,747

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl-tRNA synthetase 1

increases expression

ISO

pinostrobin results in increased expression of AARS1 mRNA

NCBI chr19:55,906,694...55,930,499
Ensembl chr19:55,906,702...55,930,497

G

ATP binding cassette subfamily B member 1A

multiple interactions
decreases activity
decreases response to substance

ISO

[pinostrobin results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Docetaxel]; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine]
ABCB1 protein results in decreased susceptibility to pinostrobin

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135

G

activin A receptor type 1

increases expression

ISO

pinostrobin results in increased expression of ACVR1 mRNA

NCBI chr 3:63,387,378...63,506,980
Ensembl chr 3:63,387,381...63,477,884

G

AT hook containing transcription factor 1

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of AHCTF1 protein

NCBI chr13:94,013,894...94,068,348
Ensembl chr13:94,014,469...94,068,058

G

AIF family member 3

increases expression

ISO

pinostrobin results in increased expression of AIFM3 mRNA

NCBI chr11:97,009,100...97,030,601
Ensembl chr11:97,008,426...97,023,334

G

apoptosis resistant E3 ubiquitin protein ligase 1

increases expression

ISO

pinostrobin results in increased expression of AREL1 mRNA

NCBI chr 6:110,296,072...110,348,751
Ensembl chr 6:110,296,072...110,320,832

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

ISO

pinostrobin results in increased expression of ASNS mRNA

NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:36,751,802...36,776,050

G

ATM serine/threonine kinase

increases expression

ISO

pinostrobin results in increased expression of ATM mRNA; pinostrobin results in increased expression of ATM protein

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:62,727,291...62,828,629

G

ATP synthase F1 subunit alpha

increases expression

ISO

pinostrobin results in increased expression of ATP5F1A mRNA

NCBI chr18:73,567,537...73,575,473
Ensembl chr18:73,567,526...73,575,922

G

Axl receptor tyrosine kinase

increases expression

ISO

pinostrobin results in increased expression of AXL mRNA

NCBI chr 1:90,392,864...90,424,123
Ensembl chr 1:90,392,864...90,424,009

G

BCL2-associated agonist of cell death

increases expression

ISO

pinostrobin results in increased expression of BAD mRNA

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034

G

BCL2-antagonist/killer 1

increases expression

ISO

pinostrobin results in increased expression of BAK1 mRNA

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

ISO
EXP

pinostrobin results in increased expression of BAX mRNA; pinostrobin results in increased expression of BAX protein
pinostrobin inhibits the reaction [Azoxymethane results in decreased expression of BAX protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of BAX mRNA]

PMID:37208425 PMID:37342552 PMID:37777166 PMID:38078205

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429

G

Bcl-2 binding component 3

increases expression

ISO

pinostrobin results in increased expression of BBC3 mRNA

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

ISO
EXP

pinostrobin results in decreased expression of BCL2 protein
pinostrobin inhibits the reaction [Azoxymethane results in increased expression of BCL2 protein]; pinostrobin inhibits the reaction [Cadmium results in decreased expression of BCL2 mRNA]

PMID:37342552 PMID:37777166 PMID:38078205

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900

G

Bcl2-like 11

increases expression

ISO

pinostrobin results in increased expression of BCL2L11 mRNA

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695

G

Bcl2-like 2

decreases expression

ISO

pinostrobin results in decreased expression of BCL2L2 mRNA

NCBI chr15:32,326,686...32,337,834
Ensembl chr15:32,326,020...32,335,379

G

Bcl2 modifying factor

increases expression

ISO

pinostrobin results in increased expression of BMF mRNA

NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258

G

calcium homeostasis modulator family member 2

increases expression

ISO

pinostrobin results in increased expression of CALHM2 mRNA

NCBI chr 1:255,963,661...255,969,387
Ensembl chr 1:255,963,663...255,969,387

G

calpain 3

increases expression

ISO

pinostrobin results in increased expression of CAPN3 mRNA

NCBI chr 3:127,860,002...127,913,677
Ensembl chr 3:127,861,589...127,911,638

G

caspase 3

increases expression
multiple interactions

ISO
EXP

pinostrobin results in increased expression of CASP3 mRNA; pinostrobin results in increased expression of CASP3 protein
[MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 mRNA; [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 protein
pinostrobin inhibits the reaction [Cadmium results in increased expression of CASP3 mRNA]; pinostrobin inhibits the reaction [Methotrexate results in increased activity of CASP3 protein]

PMID:37164308 PMID:37208425 PMID:37342552 PMID:37866152

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732

G

caspase 8

increases expression

ISO

pinostrobin results in increased expression of CASP8 mRNA

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699

G

caspase 9

increases expression

ISO

pinostrobin results in increased expression of CASP9 mRNA

Ensembl chr 5:159,391,188...159,409,648

G

catalase

multiple interactions

EXP

pinostrobin inhibits the reaction [Cadmium results in decreased activity of CAT protein]; pinostrobin inhibits the reaction [Methotrexate results in decreased activity of CAT protein]

PMID:37342552 PMID:37866152

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526

G

cystathionine beta synthase

increases expression

ISO

pinostrobin results in increased expression of CBS mRNA

NCBI chr20:9,709,394...9,733,925
Ensembl chr20:9,709,395...9,734,066

G

cyclin E1

decreases expression

ISO

pinostrobin results in decreased expression of CCNE1 protein

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:99,918,674...99,927,822

G

CD14 molecule

increases expression

ISO

pinostrobin results in increased expression of CD14 mRNA

NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,608,883...28,611,292

G

Cd70 molecule

increases expression

ISO

pinostrobin results in increased expression of CD70 mRNA

NCBI chr 9:2,093,540...2,096,692
Ensembl chr 9:2,086,848...2,096,692

G

cell division cycle 40

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of CDC40 protein

NCBI chr20:45,855,739...45,908,239
Ensembl chr20:45,855,739...45,907,978

G

cadherin 1

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of CDH1 protein

NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565

G

cyclin-dependent kinase inhibitor 1A

increases expression

ISO

pinostrobin results in increased expression of CDKN1A mRNA; pinostrobin results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969

G

cyclin-dependent kinase inhibitor 1B

increases expression

ISO

pinostrobin results in increased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498

G

CCAAT/enhancer binding protein beta

increases expression

ISO

pinostrobin results in increased expression of CEBPB mRNA

NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:176,816,859...176,838,072

G

ChaC glutathione-specific gamma-glutamylcyclotransferase 1

increases expression

ISO

pinostrobin results in increased expression of CHAC1 mRNA

NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:126,796,024...126,799,361

G

cell death-inducing DFFA-like effector b

increases expression

ISO

pinostrobin results in increased expression of CIDEB mRNA

NCBI chr15:33,222,135...33,226,407
Ensembl chr15:33,221,824...33,226,688

G

claudin 7

increases expression

ISO

pinostrobin results in increased expression of CLDN7 mRNA

NCBI chr10:55,188,670...55,190,871
Ensembl chr10:55,188,684...55,190,905

G

cysteine-rich with EGF-like domains 2

decreases expression

ISO

pinostrobin results in decreased expression of CRELD2 protein

NCBI chr 7:121,788,754...121,796,230
Ensembl chr 7:121,788,745...121,796,228

G

cystathionine gamma-lyase

increases expression

ISO

pinostrobin results in increased expression of CTH mRNA

NCBI chr 2:249,634,731...249,661,066
Ensembl chr 2:249,634,731...249,661,066

G

catenin beta 1

multiple interactions
decreases expression

ISO

pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 protein]
pinostrobin results in decreased expression of CTNNB1 mRNA; pinostrobin results in decreased expression of CTNNB1 protein

NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662

G

C-X-C motif chemokine receptor 4

increases expression

ISO

pinostrobin results in increased expression of CXCR4 mRNA

NCBI chr13:42,630,383...42,634,288
Ensembl chr13:42,630,104...42,634,459

G

decapping enzyme, scavenger

increases expression

ISO

pinostrobin results in increased expression of DCPS mRNA

NCBI chr 8:41,729,507...41,782,222
Ensembl chr 8:41,724,563...41,782,222

G

DNA-damage inducible transcript 3

increases expression

ISO

pinostrobin results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509

G

DNA-damage-inducible transcript 4

increases expression

ISO

pinostrobin results in increased expression of DDIT4 mRNA

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:28,434,944...28,437,037

G

deoxyribonuclease 1

increases expression

ISO

pinostrobin results in increased expression of DNASE1 mRNA

NCBI chr10:12,005,305...12,030,615
Ensembl chr10:12,005,306...12,010,497

G

deoxyribonuclease 2, lysosomal

increases expression

ISO

pinostrobin results in increased expression of DNASE2 mRNA

NCBI chr19:40,149,505...40,152,225
Ensembl chr19:40,149,505...40,152,225

G

double C2 domain beta

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of DOC2B protein

NCBI chr10:61,126,295...61,151,533
Ensembl chr10:61,126,295...61,151,533

G

engulfment and cell motility 1

increases expression

ISO

pinostrobin results in increased expression of ELMO1 mRNA

NCBI chr17:48,982,188...49,518,525
Ensembl chr17:48,982,188...49,518,159

G

ELKS/RAB6-interacting/CAST family member 1

increases expression

ISO

pinostrobin results in increased expression of ERC1 mRNA

NCBI chr 4:154,435,936...154,727,987
Ensembl chr 4:154,435,944...154,727,987

G

ERCC excision repair 2, TFIIH core complex helicase subunit

increases expression

ISO

pinostrobin results in increased expression of ERCC2 mRNA

NCBI chr 1:88,161,342...88,175,102
Ensembl chr 1:88,160,988...88,175,102

G

ETS variant transcription factor 6

increases expression

ISO

pinostrobin results in increased expression of ETV6 mRNA

NCBI chr 4:168,580,405...168,819,817
Ensembl chr 4:168,580,138...168,819,802

G

fibronectin type III and ankyrin repeat domains 1

increases expression

ISO

pinostrobin results in increased expression of FANK1 mRNA

NCBI chr 1:198,007,496...198,114,790
Ensembl chr 1:198,007,547...198,115,561

G

Fas cell surface death receptor

increases expression

ISO

pinostrobin results in increased expression of FAS mRNA

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104

G

F-box DNA helicase 1

increases expression

ISO

pinostrobin results in increased expression of FBH1 mRNA

NCBI chr17:71,659,351...71,697,431
Ensembl chr17:71,659,249...71,697,432

G

Fc mu receptor

increases expression

ISO

pinostrobin results in increased expression of FCMR mRNA

NCBI chr13:44,889,628...44,903,926
Ensembl chr13:44,889,697...44,906,314

G

fer-1-like family member 4

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of FER1L4 protein

NCBI chr 3:164,996,183...165,031,719
Ensembl chr 3:164,996,183...165,031,719

G

folliculin

increases expression

ISO

pinostrobin results in increased expression of FLCN mRNA

NCBI chr10:45,088,164...45,107,581
Ensembl chr10:45,088,167...45,107,309

G

flavin containing dimethylaniline monoxygenase 5

decreases phosphorylation

ISO

pinostrobin results in decreased phosphorylation of FMO5 protein

NCBI chr 2:187,885,741...187,938,468
Ensembl chr 2:187,910,964...187,938,464

G

forkhead box A1

increases expression

ISO

pinostrobin results in increased expression of FOXA1 mRNA

NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:80,800,960...80,871,191

G

forkhead box O3

multiple interactions
increases expression

ISO

pinostrobin results in increased expression of and affects the localization of FOXO3 protein
pinostrobin results in increased expression of FOXO3 mRNA

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:47,255,878...47,346,845

G

follicle stimulating hormone subunit beta

multiple interactions

EXP

pinostrobin inhibits the reaction [Methotrexate results in increased expression of FSHB protein]

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

FYN proto-oncogene, Src family tyrosine kinase

increases expression

ISO

pinostrobin results in increased expression of FYN mRNA

NCBI chr20:44,322,635...44,514,498
Ensembl chr20:44,322,361...44,515,479

G

growth arrest and DNA-damage-inducible, alpha

increases expression

ISO

pinostrobin results in increased expression of GADD45A mRNA

NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807

G

galactosidase, beta 1

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of GLB1 protein

NCBI chr 8:122,963,718...123,036,326
Ensembl chr 8:122,963,718...123,036,326

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

increases expression

ISO

pinostrobin results in increased expression of GRINA mRNA

NCBI chr 7:109,842,870...109,846,048
Ensembl chr 7:109,843,196...109,846,042

G

granulin precursor

increases expression

ISO

pinostrobin results in increased expression of GRN mRNA

NCBI chr10:87,887,834...87,893,938
Ensembl chr10:87,886,122...87,893,936

G

glutathione-disulfide reductase

multiple interactions

EXP

pinostrobin inhibits the reaction [Cadmium results in decreased activity of GSR protein]

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394

G

hepatitis A virus cellular receptor 1

multiple interactions

EXP

pinostrobin inhibits the reaction [Cadmium results in increased expression of HAVCR1 protein]

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,619,897...31,653,268

G

huntingtin interacting protein 1

increases expression

ISO

pinostrobin results in increased expression of HIP1 mRNA

NCBI chr12:26,769,868...26,904,367
Ensembl chr12:26,769,961...26,904,296

G

heme oxygenase 1

increases expression

ISO

pinostrobin results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818

G

hematopoietic SH2 domain containing

increases expression

ISO

pinostrobin results in increased expression of HSH2D mRNA

NCBI chr16:17,664,548...17,686,976
Ensembl chr16:17,669,345...17,682,013

G

inhibitor of DNA binding 3

increases expression

ISO

pinostrobin results in increased expression of ID3 mRNA

NCBI chr 5:153,656,253...153,657,860
Ensembl chr 5:153,630,498...153,657,856

G

interleukin 10

multiple interactions

EXP

pinostrobin inhibits the reaction [Azoxymethane results in decreased expression of IL10 protein]

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580

G

interleukin 1 beta

multiple interactions

EXP

pinostrobin inhibits the reaction [Cadmium results in increased expression of IL1B protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of IL1B protein]

PMID:37342552 PMID:37866152

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601

G

interleukin 6

multiple interactions

EXP

pinostrobin inhibits the reaction [Azoxymethane results in increased expression of IL6 protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of IL6 protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of IL6 protein]

PMID:37342552 PMID:37866152 PMID:38078205

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

inhibitor of growth family, member 4

increases expression

ISO

pinostrobin results in increased expression of ING4 mRNA

NCBI chr 4:159,528,183...159,536,762
Ensembl chr 4:159,528,189...159,536,761

G

inhibin subunit beta A

increases expression

ISO

pinostrobin results in increased expression of INHBA mRNA

NCBI chr17:53,787,159...53,810,942
Ensembl chr17:53,791,444...53,804,508

G

INO80 complex ATPase subunit

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of INO80 protein

NCBI chr 3:126,822,280...126,919,532
Ensembl chr 3:126,822,280...126,919,532

G

interferon regulatory factor 7

increases expression

ISO

pinostrobin results in increased expression of IRF7 mRNA

NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023

G

integrin subunit alpha M

increases expression

ISO

pinostrobin results in increased expression of ITGAM mRNA

NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943

G

inositol-tetrakisphosphate 1-kinase

increases expression

ISO

pinostrobin results in increased expression of ITPK1 mRNA

NCBI chr 6:127,475,589...127,609,320
Ensembl chr 6:127,476,808...127,609,062

G

lysine demethylase 2B

increases expression

ISO

pinostrobin results in increased expression of KDM2B mRNA

NCBI chr12:39,224,422...39,362,126
Ensembl chr12:39,235,301...39,362,127

G

lipocalin 2

multiple interactions

EXP

pinostrobin inhibits the reaction [Cadmium results in increased expression of LCN2 protein]

NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842

G

galectin 2

increases expression

ISO

pinostrobin results in increased expression of LGALS2 mRNA

NCBI chr 7:112,283,630...112,290,228
Ensembl chr 7:112,282,822...112,285,392

G

luteinizing hormone subunit beta

multiple interactions

EXP

pinostrobin inhibits the reaction [Methotrexate results in increased expression of LHB protein]

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

MAP-kinase activating death domain

increases expression

ISO

pinostrobin results in increased expression of MADD mRNA

NCBI chr 3:97,570,141...97,613,688
Ensembl chr 3:97,570,787...97,613,509

G

MCL1 apoptosis regulator, BCL2 family member

decreases expression

ISO

pinostrobin results in decreased expression of MCL1 mRNA

NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782

G

myocyte enhancer factor 2a

increases expression

ISO

pinostrobin results in increased expression of MEF2A mRNA

NCBI chr 1:130,258,083...130,392,819
Ensembl chr 1:130,260,339...130,392,162

G

myocyte enhancer factor 2D

increases expression

ISO

pinostrobin results in increased expression of MEF2D mRNA

NCBI chr 2:175,904,332...175,933,451
Ensembl chr 2:175,903,959...175,930,760

G

microRNA 410

decreases expression
multiple interactions

ISO

pinostrobin results in decreased expression of MIR410 mRNA
[MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 mRNA; [MIR410 mRNA co-treated with pinostrobin] results in increased expression of CASP3 protein; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 protein]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in increased expression of CTNNB1 protein]

NCBI chr 6:134,579,763...134,579,838
Ensembl chr 6:134,579,759...134,579,839

G

mitochondrial ribosomal protein L1

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of MRPL1 protein

NCBI chr14:13,604,498...13,663,633
Ensembl chr14:13,604,499...13,663,602

G

metallothionein 3

increases expression

ISO

pinostrobin results in increased expression of MT3 mRNA

NCBI chr19:10,854,676...10,856,080
Ensembl chr19:10,854,677...10,856,080

G

mutY DNA glycosylase

increases expression

ISO

pinostrobin results in increased expression of MUTYH mRNA

NCBI chr 5:135,510,666...135,522,777
Ensembl chr 5:135,517,695...135,522,776

G

NLR family, apoptosis inhibitory protein 6

increases expression

ISO

pinostrobin results in increased expression of NAIP mRNA

NCBI chr 2:33,241,520...33,293,184
Ensembl chr 2:33,241,521...33,276,859

G

ninjurin 1

increases expression

ISO

pinostrobin results in increased expression of NINJ1 mRNA

NCBI chr17:15,659,208...15,668,115
Ensembl chr17:15,659,200...15,668,063

G

nischarin

increases expression

ISO

pinostrobin results in increased expression of NISCH mRNA

NCBI chr16:6,370,809...6,407,104
Ensembl chr16:6,370,809...6,407,387

G

NLR family, pyrin domain containing 1A

increases expression

ISO

pinostrobin results in increased expression of NLRP1 mRNA

NCBI chr10:56,277,134...56,332,229
Ensembl chr10:56,277,134...56,323,880

G

nitric oxide synthase 2

multiple interactions

EXP

pinostrobin inhibits the reaction [Cadmium results in increased expression of NOS2 protein]; pinostrobin inhibits the reaction [Methotrexate results in increased activity of NOS2 protein]

PMID:37342552 PMID:37866152

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880

G

nitric oxide synthase 3

increases expression

ISO

pinostrobin results in increased expression of NOS3 mRNA

NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:11,686,268...11,706,664

G

nuclear receptor subfamily 4, group A, member 1

increases expression

ISO

pinostrobin results in increased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041

G

neurotensin receptor 1

increases expression

ISO

pinostrobin results in increased expression of NTSR1 mRNA

NCBI chr 3:187,983,778...188,033,934
Ensembl chr 3:187,983,778...188,033,934

G

purinergic receptor P2X 1

increases expression

ISO

pinostrobin results in increased expression of P2RX1 mRNA

NCBI chr10:58,117,107...58,132,167
Ensembl chr10:58,117,088...58,132,164

G

purinergic receptor P2X 7

increases expression

ISO

pinostrobin results in increased expression of P2RX7 mRNA

NCBI chr12:39,550,531...39,594,984
Ensembl chr12:39,540,567...39,595,193

G

phosphodiesterase 1B

increases expression

ISO

pinostrobin results in increased expression of PDE1B mRNA

NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:136,505,689...136,533,033

G

pellino E3 ubiquitin protein ligase family member 3

increases expression

ISO

pinostrobin results in increased expression of PELI3 mRNA

NCBI chr 1:211,659,416...211,672,280
Ensembl chr 1:211,661,610...211,672,239

G

pleckstrin homology-like domain, family A, member 3

increases expression

ISO

pinostrobin results in increased expression of PHLDA3 mRNA

NCBI chr13:49,745,003...49,748,088
Ensembl chr13:49,742,591...49,749,621

G

Pim-2 proto-oncogene, serine/threonine kinase

increases expression

ISO

pinostrobin results in increased expression of PIM2 mRNA

NCBI chr X:17,289,509...17,294,778
Ensembl chr X:17,289,509...17,294,778

G

plasminogen activator, urokinase receptor

increases expression

ISO

pinostrobin results in increased expression of PLAUR mRNA

NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:89,178,453...89,198,130

G

phospholipase D1

increases expression

ISO

pinostrobin results in increased expression of PLD1 protein

NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:112,777,951...112,976,245

G

plectin

decreases expression

ISO

pinostrobin results in decreased expression of PLEC protein

NCBI chr 7:109,768,447...109,829,798
Ensembl chr 7:109,768,447...109,828,089

G

plexin D1

increases expression

ISO

pinostrobin results in increased expression of PLXND1 mRNA

NCBI chr 4:150,675,377...150,715,706
Ensembl chr 4:150,675,377...150,715,566

G

peripheral myelin protein 22

increases expression

ISO

pinostrobin results in increased expression of PMP22 mRNA

NCBI chr10:48,294,932...48,324,941
Ensembl chr10:48,297,437...48,324,940

G

POU class 3 homeobox 3

increases expression

ISO

pinostrobin results in increased expression of POU3F3 mRNA

NCBI chr 9:52,438,026...52,441,152
Ensembl chr 9:52,435,625...52,454,705

G

peroxisome proliferator activated receptor alpha

increases expression

ISO

pinostrobin results in increased expression of PPARA mRNA

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714

G

prostaglandin-endoperoxide synthase 2

multiple interactions

EXP

pinostrobin inhibits the reaction [Cadmium results in increased expression of PTGS2 protein]

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320

G

protein tyrosine kinase 2 beta

increases expression

ISO

pinostrobin results in increased expression of PTK2B mRNA

NCBI chr15:44,536,275...44,656,754
Ensembl chr15:44,531,249...44,656,806

G

glutaminyl-tRNA synthetase 1

increases expression

ISO

pinostrobin results in increased expression of QARS1 mRNA

NCBI chr 8:118,086,243...118,094,274
Ensembl chr 8:118,086,228...118,094,274

G

ret proto-oncogene

increases expression

ISO

pinostrobin results in increased expression of RET mRNA

NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:152,998,812...153,040,556

G

ring finger protein 130

increases expression

ISO

pinostrobin results in increased expression of RNF130 mRNA

NCBI chr10:34,843,920...34,957,130
Ensembl chr10:34,843,915...34,960,408

G

ring finger protein 216

increases expression

ISO

pinostrobin results in increased expression of RNF216 mRNA

NCBI chr12:16,568,327...16,689,868
Ensembl chr12:16,568,347...16,690,989

G

RT1 class I, locus CE5

increases expression

ISO

pinostrobin results in increased expression of HLA-F mRNA

NCBI chr20:3,407,880...3,484,130

G

rhotekin

increases expression

ISO

pinostrobin results in increased expression of RTKN mRNA

NCBI chr 4:117,198,496...117,215,660
Ensembl chr 4:117,198,647...117,215,660

G

sec1 family domain containing 2

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of SCFD2 protein

NCBI chr14:34,037,392...34,369,423
Ensembl chr14:34,037,430...34,363,436

G

sodium voltage-gated channel alpha subunit 2

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of SCN2A protein

NCBI chr 3:70,710,862...70,845,569
Ensembl chr 3:70,710,954...70,845,279

G

scleraxis bHLH transcription factor

increases expression

ISO

pinostrobin results in increased expression of SCX mRNA

NCBI chr 7:110,056,897...110,059,283
Ensembl chr 7:110,054,601...110,061,438

G

selenoprotein S

increases expression

ISO

pinostrobin results in increased expression of SELENOS mRNA

NCBI chr 1:129,070,240...129,080,007
Ensembl chr 1:129,070,230...129,077,991

G

serpin family F member 1

increases expression

ISO

pinostrobin results in increased expression of SERPINF1 mRNA

NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,748,506...60,760,898

G

secreted frizzled-related protein 5

multiple interactions
increases phosphorylation
increases expression

ISO

pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 mRNA]; pinostrobin inhibits the reaction [MIR410 mRNA results in decreased expression of SFRP5 protein]
pinostrobin results in increased phosphorylation of SFRP5 protein
pinostrobin results in increased expression of SFRP5 mRNA; pinostrobin results in increased expression of SFRP5 protein

NCBI chr 1:250,956,050...250,960,512
Ensembl chr 1:250,956,050...250,960,512

G

SHANK-associated RH domain interactor

increases expression

ISO

pinostrobin results in increased expression of SHARPIN mRNA

NCBI chr 7:109,951,336...109,955,552
Ensembl chr 7:109,950,345...109,955,552

G

shisa family member 5

increases expression

ISO

pinostrobin results in increased expression of SHISA5 mRNA

NCBI chr 8:118,569,975...118,584,880
Ensembl chr 8:118,569,975...118,584,880

G

solute carrier family 10, member 5

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of SLC10A5 protein

NCBI chr 2:93,364,959...93,366,263
Ensembl chr 2:93,360,766...93,368,978

G

solute carrier family 25 member 5, pseudogene 11

increases expression

ISO

pinostrobin results in increased expression of SLC25A6 mRNA

NCBI chr18:70,846,358...70,847,597
Ensembl chr18:70,846,358...70,847,597

G

solute carrier family 46, member 2

increases expression

ISO

pinostrobin results in increased expression of SLC46A2 mRNA

NCBI chr 5:79,594,003...79,603,074
Ensembl chr 5:79,595,150...79,603,114

G

solute carrier family 7 member 11

increases expression

ISO

pinostrobin results in increased expression of SLC7A11 mRNA

NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695

G

solute carrier organic anion transporter family, member 5A1

increases expression

ISO

pinostrobin results in increased expression of SLCO5A1 protein

NCBI chr 5:11,012,001...11,141,180
Ensembl chr 5:11,012,075...11,141,177

G

SMAD family member 3

increases expression

ISO

pinostrobin results in increased expression of SMAD3 mRNA

NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324

G

small integral membrane protein 7

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of SMIM7 protein

NCBI chr16:17,308,466...17,312,384
Ensembl chr16:17,308,395...17,312,371

G

signal transducing adaptor family member 2

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of STAP2 protein

NCBI chr 9:915,546...924,604
Ensembl chr 9:915,550...924,380

G

steroidogenic acute regulatory protein

increases expression

ISO

pinostrobin results in increased expression of STAR mRNA

NCBI chr16:72,969,824...72,974,447
Ensembl chr16:72,961,518...72,974,447

G

syntaxin binding protein 1

increases expression

ISO

pinostrobin results in increased expression of STXBP1 mRNA

NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:36,474,428...36,536,058

G

synaptonemal complex protein 2-like

increases expression

ISO

pinostrobin results in increased expression of SYCP2L mRNA

NCBI chr17:23,798,424...23,851,017
Ensembl chr17:23,798,649...23,854,050

G

TATA-box binding protein associated factor 10

increases expression

ISO

pinostrobin results in increased expression of TAF10 mRNA

NCBI chr 1:169,506,940...169,508,234
Ensembl chr 1:169,506,940...169,508,208

G

T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3

increases expression

ISO

pinostrobin results in increased expression of TCIRG1 mRNA

NCBI chr 1:210,556,270...210,568,021
Ensembl chr 1:210,556,270...210,568,033

G

transmembrane protein 109

increases expression

ISO

pinostrobin results in increased expression of TMEM109 mRNA

NCBI chr 1:216,944,516...216,955,091
Ensembl chr 1:216,944,519...216,955,138

G

transmembrane protein 39a

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of TMEM39A protein

NCBI chr11:75,666,154...75,695,486
Ensembl chr11:75,666,154...75,695,486

G

transmembrane protein 79

increases expression

ISO

pinostrobin results in increased expression of TMEM79 mRNA

NCBI chr 2:176,096,092...176,100,996
Ensembl chr 2:176,096,092...176,100,870

G

transmembrane serine protease 4

increases phosphorylation

ISO

pinostrobin results in increased phosphorylation of TMPRSS4 protein

NCBI chr 8:54,372,805...54,405,157
Ensembl chr 8:54,372,805...54,405,157

G

tumor necrosis factor

multiple interactions

EXP

pinostrobin inhibits the reaction [Azoxymethane results in increased expression of TNF protein]; pinostrobin inhibits the reaction [Cadmium results in increased expression of TNF protein]; pinostrobin inhibits the reaction [Methotrexate results in increased expression of TNF protein]

PMID:37342552 PMID:37866152 PMID:38078205

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303

G

TNF receptor superfamily member 11A

multiple interactions

EXP

pinostrobin inhibits the reaction [Methotrexate results in increased expression of TNFRSF11A protein]

NCBI chr13:22,442,930...22,501,257
Ensembl chr13:22,442,665...22,501,257

G

TNF superfamily member 14

increases expression

ISO

pinostrobin results in increased expression of TNFSF14 mRNA

NCBI chr 9:2,155,270...2,160,100
Ensembl chr 9:2,155,270...2,160,191

G

TNF superfamily member 9

increases expression

ISO

pinostrobin results in increased expression of TNFSF9 mRNA

NCBI chr 9:2,031,011...2,033,345
Ensembl chr 9:2,030,953...2,033,339

G

tumor protein p53

increases expression

ISO

pinostrobin results in increased expression of TP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299

G

TNF receptor-associated protein 1

increases expression

ISO

pinostrobin results in increased expression of TRAP1 mRNA

NCBI chr10:11,971,259...12,005,306
Ensembl chr10:11,970,995...12,005,355

G

tribbles pseudokinase 3

increases expression

ISO

pinostrobin results in increased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:161,269,955...161,274,802

G

transient receptor potential cation channel, subfamily M, member 2

increases expression

ISO

pinostrobin results in increased expression of TRPM2 mRNA

NCBI chr20:10,703,190...10,752,795
Ensembl chr20:10,704,482...10,752,802

G

transient receptor potential cation channel, subfamily V, member 1

increases expression

ISO

pinostrobin results in increased expression of TRPV1 mRNA

NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021

G

vascular endothelial growth factor A

increases expression

ISO

pinostrobin results in increased expression of VEGFA mRNA

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194

G

X-box binding protein 1

increases expression

ISO

pinostrobin results in increased expression of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706

G

zinc finger protein 746

increases expression

ISO

pinostrobin results in increased expression of ZNF746 mRNA

NCBI chr 4:78,385,945...78,410,240
Ensembl chr 4:78,385,945...78,409,832

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 19, subfamily a, polypeptide 1

decreases activity

ISO

sakuranetin results in decreased activity of CYP19A1 protein

NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

protein tyrosine phosphatase, non-receptor type 1

decreases activity

ISO

sanggenon G results in decreased activity of PTPN1 protein

NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 4

decreases secretion

ISO

silidianin results in decreased secretion of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549

G

interleukin 5

decreases secretion
decreases expression

ISO

silidianin results in decreased secretion of IL5 protein
silidianin results in decreased expression of IL5 mRNA

NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003

G

platelet factor 4

multiple interactions

ISO

silidianin inhibits the reaction [Adenosine Diphosphate results in increased secretion of PF4 protein]

NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392

G

vasodilator-stimulated phosphoprotein

increases phosphorylation

ISO

silidianin results in increased phosphorylation of VASP protein

NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:88,038,037...88,058,650

sophoraflavanone B

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression
increases activity

ISO

[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein; fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]
8-prenylnaringenin results in increased expression of ALPL mRNA
8-prenylnaringenin results in increased activity of ALPL protein

PMID:12650720 PMID:16019205

NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167

G

complement C3

increases expression

EXP

8-prenylnaringenin results in increased expression of C3 mRNA

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339

G

carbonyl reductase 1

multiple interactions

ISO

8-prenylnaringenin inhibits the reaction [CBR1 protein results in increased metabolism of Daunorubicin]; 8-prenylnaringenin inhibits the reaction [CBR1 protein results in increased reduction of 2,3-hexanedione]

NCBI chr11:46,346,405...46,348,815
Ensembl chr11:46,378,411...46,381,104
Ensembl chr11:46,378,411...46,381,104

G

glycoprotein hormones, alpha polypeptide

decreases expression

EXP

8-prenylnaringenin results in decreased expression of CGA mRNA

NCBI chr 5:54,283,109...54,295,464
Ensembl chr 5:54,235,019...54,295,464

G

casein beta

increases expression
multiple interactions

EXP

8-prenylnaringenin results in increased expression of CSN2 mRNA
Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of CSN2 mRNA]

NCBI chr14:20,601,824...20,609,061
Ensembl chr14:20,601,824...20,609,060

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity
decreases expression

ISO

8-prenylnaringenin results in decreased activity of CYP1A1 protein
8-prenylnaringenin results in decreased expression of CYP1A1 mRNA

PMID:19770484 PMID:32986415

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
increases expression

ISO

8-prenylnaringenin results in decreased activity of CYP1A2 protein
8-prenylnaringenin results in increased expression of CYP1A2 mRNA

PMID:15672752 PMID:19770484

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

ISO

8-prenylnaringenin results in decreased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

G

estrogen receptor 1

multiple interactions
decreases expression
increases expression
increases activity

ISO
EXP

8-prenylnaringenin analog binds to and results in increased activity of ESR1 protein; 8-prenylnaringenin binds to and results in increased activity of ESR1 protein; [8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [8-prenylnaringenin results in decreased expression of ESR1 protein]; Fulvestrant inhibits the reaction [[8-prenylnaringenin binds to ESR1 protein] which results in increased activity of ALPL protein]
8-prenylnaringenin results in increased expression of ESR1 mRNA
[Fulvestrant co-treated with 8-prenylnaringenin] results in increased expression of ESR1 mRNA; Fulvestrant inhibits the reaction [8-prenylnaringenin results in decreased expression of ESR1 protein]
8-prenylnaringenin results in increased activity of ESR1 protein

PMID:12623674 PMID:12650720 PMID:15876408 PMID:16076101 PMID:17149865 More...

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354

G

estrogen receptor 2

decreases expression
multiple interactions
increases expression
increases activity

EXP
ISO

8-prenylnaringenin results in decreased expression of ESR2 mRNA
[Fulvestrant co-treated with 8-prenylnaringenin] results in increased expression of ESR2 mRNA
8-prenylnaringenin results in increased expression of ESR2 mRNA
8-prenylnaringenin analog binds to and results in decreased activity of ESR2 protein; 8-prenylnaringenin binds to and results in increased activity of ESR2 protein
8-prenylnaringenin results in increased activity of ESR2 protein

PMID:16076101 PMID:16522720 PMID:17149865 PMID:17716812 PMID:34848279

NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709

G

follicle stimulating hormone subunit beta

decreases expression

EXP

8-prenylnaringenin results in decreased expression of FSHB protein

NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072

G

gonadotropin releasing hormone receptor

decreases expression

EXP

8-prenylnaringenin results in decreased expression of GNRHR mRNA

NCBI chr14:22,211,666...22,229,654

G

insulin-like growth factor 1

multiple interactions

EXP

[Fulvestrant co-treated with 8-prenylnaringenin] results in decreased expression of IGF1 mRNA

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764

G

insulin-like growth factor 1 receptor

increases expression

EXP

8-prenylnaringenin results in increased expression of IGF1R mRNA

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:130,959,997...131,248,664

G

interleukin 6

decreases expression

ISO

8-prenylnaringenin results in decreased expression of IL6 mRNA

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610

G

kinesin family member 11

multiple interactions
increases expression

EXP

Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of KIF11 mRNA]

NCBI chr 1:244,494,916...244,589,250
Ensembl chr 1:244,494,875...244,589,250

G

kinesin family member 18A

increases expression
multiple interactions

EXP

8-prenylnaringenin results in increased expression of KIF18A mRNA
Methylcholanthrene inhibits the reaction [8-prenylnaringenin results in increased expression of KIF18A mRNA]

NCBI chr 3:116,219,007...116,279,378
Ensembl chr 3:116,219,007...116,279,227

G

kinesin family member 2C

increases expression

EXP

8-prenylnaringenin results in increased expression of KIF2C mRNA

NCBI chr 5:135,873,925...135,899,267
Ensembl chr 5:135,873,925...135,899,212

G

luteinizing hormone subunit beta

decreases expression

EXP

8-prenylnaringenin results in decreased expression of LHB mRNA; 8-prenylnaringenin results in decreased expression of LHB protein

NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445

G

marker of proliferation Ki-67

decreases expression

EXP

8-prenylnaringenin results in decreased expression of MKI67 mRNA

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593

G

progesterone receptor

increases expression
multiple interactions

ISO
EXP

8-prenylnaringenin results in increased expression of PGR mRNA
Fulvestrant inhibits the reaction [8-prenylnaringenin results in increased expression of PGR mRNA]
8-prenylnaringenin results in increased expression of PGR mRNA; 8-prenylnaringenin results in increased expression of PGR protein

PMID:16076101 PMID:16522720 PMID:16837889 PMID:34848279

NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:14,354,398...14,413,271

G

prolactin

increases expression

EXP

8-prenylnaringenin results in increased expression of PRL protein

NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217

G

trefoil factor 1

increases expression

ISO

8-prenylnaringenin results in increased expression of TFF1 mRNA

NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,237,095...9,240,956

G

von Willebrand factor

increases expression

ISO

8-prenylnaringenin results in increased expression of VWF mRNA

NCBI chr 4:160,042,900...160,177,757
Ensembl chr 4:160,047,982...160,177,757

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases activity

ISO

sophoranone results in decreased activity of CYP2C19 protein

NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases activity

ISO

sophoranone results in decreased activity of CYP2D6 protein

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity

ISO

sophoranone results in decreased activity of CYP3A4 protein

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20874
chemical entity	20872
atom	20872
nonmetal atom	20781
oxygen atom	20437
oxygen molecular entity	20437
flavonoids	12108
flavonoid	7602
flavans	3662
flavanones	597
(2S)-5,7,3',4'-Tetrahydroxy-6-(1,1-dimethylallyl)flavanone	0
(2S)-5,7,4'-Trihydroxy-2'-methoxy-8-prenyl-5'-(1,1-dimethylallyl)flavanone	0
(2S)-flavan-4-one +	325
(2S,2 ́ ́S)-6-Lavandulyl-7-methoxy-5,2 ́,4 ́-trihydroxylflavanone	0
(2S,2′'S)-6-lavandulyl-5,7,2′,4′-tetrahydroxylflavanone	0
(2S,2′′S)-6-lavandulyl-7,4′-dimethoxy-5,2′-dihydroxylflavanone	0
(S)-(E)-2'-(3,6-Dimethyl-2-heptenyl)-3',4',7-trihydroxyflavanone	0
(S)-(E)-8-(3,6-Dimethyl-2-heptenyl)-4',5,7-trihydroxyflavanone	0
(S)-3',4',5,7-Tetrahydroxy-5',8-diprenylflavanone	0
(S)-4',5,7-Trihydroxy-3'-prenylflavanone	0
(S)-4',5,7-Trihydroxy-6-prenylflavanone	0
(S)-4',7-Dihydroxy-3',8-diprenylflavanone	0
(S)-5,7-Dihydroxy-6,8-dimethylflavanone	0
(S)-Cajaflavanone	0
1'''-Hydroxy-2''',3'''-Epoxylupinifolin	0
2'',3''-Dihydroxylupinifolin	0
2',4'-Dihydroxy-2''-(1-hydroxy-1-methylethyl)dihydrofuro[2,3-h]flavanone	0
2'-Prenyleriodictyol	0
2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(8-hydroxy-3,7-dimethylocta-2,6-dien-1-yl)-6-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H-1-benzopyran-4-one	0
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-4-one	0
2-(3,4-dihydroxyphenyl)-7-hydroxy-3,4-dihydro-2H-1-benzopyran-4-one	0
2-[2,3-dihydroxy-4,6-dimethoxy-5-(3-methylbut-2-en-1-yl)phenyl]-7-hydroxy-3,4-dihydro-2H-1-benzopyran-4-one	0
3',4',5'-pentahydroxyflavanone	0
3',5'-unsubstituted flavanone	0
3'-Methoxylupinifolin	0
3,4,5-trihydroxy-6-[3-hydroxy-2-(7-hydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-2-yl)-5-methoxy-4-(3-methylbut-2-en-1-yl)phenoxy]oxane-2-carboxylic acid	0
3-Hydroxyglabrol	0
3-Methylnaringenin	0
3-[(4-methoxyphenyl)methylidene]-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one	0
4',5,8-Trihydroxyflavanone	0
5,2',3'-Trihydroxy-6,7-methylenedioxyflavanone	0
5,6,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one	0
5,7,2'-Trihydroxyflavanone	0
5,7,3',5'-Tetrahydroxy-6-methylflavanone	0
5,7,3'-Trihydroxyflavanone	0
5,7,4'-Trihydroxyflavanone 7-sulfate	0
5,7-Dihydroxy-3',4'-dimethoxy-5'-prenylflavanone	0
5,7-Dihydroxy-4'-methoxy-8-C-prenyl-3'-(3-hydroxy-3-methylbutyl)flavanone	0
5,7-Dihydroxy-4'-methoxy-8-C-prenylflavanone	0
5,7-Dihydroxy-8-C-(4-hydroxy-3-methyl-2-butenyl)flavanone	0
5,7-Dihydroxy-8-C-geranylflavanone	0
5,7-dihydroxy-2-(2,3,4-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one	0
5,7-dihydroxy-2-(4-methoxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one	0
5-Hydroxy-7-(3-methyl-2,3-epoxybutoxy)flavanone	0
6-C-(3-Hydroxyisopentyl)eriodictyol	0
7,8,4'-Trihydroxyflavanone	0
7-O-Prenylpinocembrin	0
8-C-Prenyl-6'',6''-dimethylpyrano(2'',3'':7,6)flavanone	0
8-[(2E)-3,7-dimethylocta-2,6-dienyl]-5,7-dihydroxy-2-phenyl-2,3-dihydrochromen-4-one	0
8-prenyllepidissipyrone	0
Abyssinone IV	0
Alopecurone G	0
Amoritin	0
Bavachinin	20
Brosimacutin A	0
Brosimacutin B	0
Brosimacutin C	0
Brosimacutin D	0
Candidone	0
Dihydrobaicalein	0
Dihydronorwogonin	0
Emoroidenone	0
Euchrenone a14	0
Euchrenone a15	0
Euchrestaflavanone A	0
Exiguaflavanone D	0
Exiguaflavanone L	0
Exiguaflavanone M	0
Flemiflavanone D	0
Flowerine	0
Flowerone	0
Glabrol	0
Heteroflavanone B	0
Heteroflavanone C	0
Hydroxysophoranone	0
Isoamoritin	0
Isobavachin	16
Isoderricidin	0
Isoderricin A	0
Isoxanthohumol	5
Kanzonol S	0
Kanzonol Z	0
Kenusanone D	0
Kenusanone E	0
Kurziflavolactone A	0
Kurziflavolactone B	0
Kushenol A	0
Kushenol B	0
Kushenol Q	0
Kushenol V	0
Kushenol W	0
Kuwanon D	0
Kuwanon E	0
Kuwanon L	1
Laurifolin (flavonoid)	0
Laxiflorin	0
Leachianone D	0
Lehmannin	0
Lepidissipyrone	0
Lespedezaflavanone E	0
Lespedezaflavanone F	0
Licoagrodin	0
Licoleafol	0
Lonchocarpol B	0
Lonchocarpol E	0
Lupinenol	0
Lupiniol A1	0
Marini	0
Maximaflavanone A	0
Norartocarpanone	0
Ovaliflavanone A	0
Ovaliflavanone B	0
Ovaliflavanone C	0
Phellodensin D	0
Pinocembrin 7-O-benzoate	0
Pinocembrin 7-[4-(1-hydroxyethyl)phenyl] ether	0
Poriol	0
Sanggenon G	1
Shinflavanone	0
Sigmoidin D	0
Silidianin	4
Tephrinone	0
Tephrorin A	0
Tephrowatsin C	0
Tomentosanol D	0
[4-(5,7-dihydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-2-yl)phenyl]oxidanesulfonic acid	0
exiguaflavanone E	0
flavanone +	24
flavanone glycoside +	156
glyflavanone A	0
hydroxyflavanone +	579
methoxyflavanone +	328
rac 8-Prenylnaringenin	0
Path 2
Term	Annotations
CHEBI ontology	20874
subatomic particle	20883
composite particle	20883
hadron	20872
baryon	20883
nucleon	20872
atomic nucleus	20883
atom	20872
main group element atom	20796
p-block element atom	20796
carbon group element atom	20712
carbon atom	20706
organic molecular entity	20706
organic molecule	20499
organic cyclic compound	20390
organic heterocyclic compound	19381
oxacycle	18273
benzopyran	10790
1-benzopyran	10376
flavans	3662
flavanones	597
(2S)-5,7,3',4'-Tetrahydroxy-6-(1,1-dimethylallyl)flavanone	0
(2S)-5,7,4'-Trihydroxy-2'-methoxy-8-prenyl-5'-(1,1-dimethylallyl)flavanone	0
(2S)-flavan-4-one +	325
(2S,2 ́ ́S)-6-Lavandulyl-7-methoxy-5,2 ́,4 ́-trihydroxylflavanone	0
(2S,2′'S)-6-lavandulyl-5,7,2′,4′-tetrahydroxylflavanone	0
(2S,2′′S)-6-lavandulyl-7,4′-dimethoxy-5,2′-dihydroxylflavanone	0
(S)-(E)-2'-(3,6-Dimethyl-2-heptenyl)-3',4',7-trihydroxyflavanone	0
(S)-(E)-8-(3,6-Dimethyl-2-heptenyl)-4',5,7-trihydroxyflavanone	0
(S)-3',4',5,7-Tetrahydroxy-5',8-diprenylflavanone	0
(S)-4',5,7-Trihydroxy-3'-prenylflavanone	0
(S)-4',5,7-Trihydroxy-6-prenylflavanone	0
(S)-4',7-Dihydroxy-3',8-diprenylflavanone	0
(S)-5,7-Dihydroxy-6,8-dimethylflavanone	0
(S)-Cajaflavanone	0
1'''-Hydroxy-2''',3'''-Epoxylupinifolin	0
2'',3''-Dihydroxylupinifolin	0
2',4'-Dihydroxy-2''-(1-hydroxy-1-methylethyl)dihydrofuro[2,3-h]flavanone	0
2'-Prenyleriodictyol	0
2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(8-hydroxy-3,7-dimethylocta-2,6-dien-1-yl)-6-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H-1-benzopyran-4-one	0
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3,4-dihydro-2H-1-benzopyran-4-one	0
2-(3,4-dihydroxyphenyl)-7-hydroxy-3,4-dihydro-2H-1-benzopyran-4-one	0
2-[2,3-dihydroxy-4,6-dimethoxy-5-(3-methylbut-2-en-1-yl)phenyl]-7-hydroxy-3,4-dihydro-2H-1-benzopyran-4-one	0
3',4',5'-pentahydroxyflavanone	0
3',5'-unsubstituted flavanone	0
3'-Methoxylupinifolin	0
3,4,5-trihydroxy-6-[3-hydroxy-2-(7-hydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-2-yl)-5-methoxy-4-(3-methylbut-2-en-1-yl)phenoxy]oxane-2-carboxylic acid	0
3-Hydroxyglabrol	0
3-Methylnaringenin	0
3-[(4-methoxyphenyl)methylidene]-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one	0
4',5,8-Trihydroxyflavanone	0
5,2',3'-Trihydroxy-6,7-methylenedioxyflavanone	0
5,6,7-trihydroxy-2-(3-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one	0
5,7,2'-Trihydroxyflavanone	0
5,7,3',5'-Tetrahydroxy-6-methylflavanone	0
5,7,3'-Trihydroxyflavanone	0
5,7,4'-Trihydroxyflavanone 7-sulfate	0
5,7-Dihydroxy-3',4'-dimethoxy-5'-prenylflavanone	0
5,7-Dihydroxy-4'-methoxy-8-C-prenyl-3'-(3-hydroxy-3-methylbutyl)flavanone	0
5,7-Dihydroxy-4'-methoxy-8-C-prenylflavanone	0
5,7-Dihydroxy-8-C-(4-hydroxy-3-methyl-2-butenyl)flavanone	0
5,7-Dihydroxy-8-C-geranylflavanone	0
5,7-dihydroxy-2-(2,3,4-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one	0
5,7-dihydroxy-2-(4-methoxyphenyl)-6-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one	0
5-Hydroxy-7-(3-methyl-2,3-epoxybutoxy)flavanone	0
6-C-(3-Hydroxyisopentyl)eriodictyol	0
7,8,4'-Trihydroxyflavanone	0
7-O-Prenylpinocembrin	0
8-C-Prenyl-6'',6''-dimethylpyrano(2'',3'':7,6)flavanone	0
8-[(2E)-3,7-dimethylocta-2,6-dienyl]-5,7-dihydroxy-2-phenyl-2,3-dihydrochromen-4-one	0
8-prenyllepidissipyrone	0
Abyssinone IV	0
Alopecurone G	0
Amoritin	0
Bavachinin	20
Brosimacutin A	0
Brosimacutin B	0
Brosimacutin C	0
Brosimacutin D	0
Candidone	0
Dihydrobaicalein	0
Dihydronorwogonin	0
Emoroidenone	0
Euchrenone a14	0
Euchrenone a15	0
Euchrestaflavanone A	0
Exiguaflavanone D	0
Exiguaflavanone L	0
Exiguaflavanone M	0
Flemiflavanone D	0
Flowerine	0
Flowerone	0
Glabrol	0
Heteroflavanone B	0
Heteroflavanone C	0
Hydroxysophoranone	0
Isoamoritin	0
Isobavachin	16
Isoderricidin	0
Isoderricin A	0
Isoxanthohumol	5
Kanzonol S	0
Kanzonol Z	0
Kenusanone D	0
Kenusanone E	0
Kurziflavolactone A	0
Kurziflavolactone B	0
Kushenol A	0
Kushenol B	0
Kushenol Q	0
Kushenol V	0
Kushenol W	0
Kuwanon D	0
Kuwanon E	0
Kuwanon L	1
Laurifolin (flavonoid)	0
Laxiflorin	0
Leachianone D	0
Lehmannin	0
Lepidissipyrone	0
Lespedezaflavanone E	0
Lespedezaflavanone F	0
Licoagrodin	0
Licoleafol	0
Lonchocarpol B	0
Lonchocarpol E	0
Lupinenol	0
Lupiniol A1	0
Marini	0
Maximaflavanone A	0
Norartocarpanone	0
Ovaliflavanone A	0
Ovaliflavanone B	0
Ovaliflavanone C	0
Phellodensin D	0
Pinocembrin 7-O-benzoate	0
Pinocembrin 7-[4-(1-hydroxyethyl)phenyl] ether	0
Poriol	0
Sanggenon G	1
Shinflavanone	0
Sigmoidin D	0
Silidianin	4
Tephrinone	0
Tephrorin A	0
Tephrowatsin C	0
Tomentosanol D	0
[4-(5,7-dihydroxy-4-oxo-3,4-dihydro-2H-1-benzopyran-2-yl)phenyl]oxidanesulfonic acid	0
exiguaflavanone E	0
flavanone +	24
flavanone glycoside +	156
glyflavanone A	0
hydroxyflavanone +	579
methoxyflavanone +	328
rac 8-Prenylnaringenin	0

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