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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:octanoic acid
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Accession:CHEBI:28837 term browser browse the term
Definition:A straight-chain saturated fatty acid that is heptane in which one of the hydrogens of a terminal methyl group has been replaced by a carboxy group. Octanoic acid is also known as caprylic acid.
Synonyms:related_synonym: 1-heptanecarboxylic acid;   8:0;   Acide octanoique;   Acido octanoico;   Acidum octanocium;   C8:0;   CH3-[CH2]6-COOH;   Caprylic acid;   Kaprylsaeure;   OCTANOIC ACID (CAPRYLIC ACID);   Octansaeure;   Octylic acid;   acidum octanoicum;   n-caprylic acid;   n-octanoic acid;   n-octoic acid;   n-octylic acid;   octoic acid
 alt_id: CHEBI:25648;   CHEBI:3373;   CHEBI:44501
 xref: CAS:124-07-2;   DrugBank:DB04519;   Gmelin:142966;   HMDB:HMDB0000482;   KNApSAcK:C00001231
 xref_mesh: MESH:C031492
 xref: Reaxys:1747180;   drugcentral:3998;   kegg.compound:C06423;   kegg.drug:D05220;   lipidmaps:LMFA01010008;   metacyc.compound:CPD-195;   pdb-ccd:OCA;   pubmed:16162522;   pubmed:16872526;   pubmed:19096058;   wikipedia.en:Caprylic_acid
 chemrof_formula: C8H16O2
 chemrof_smiles: CCCCCCCC(=O)O
 chemrof_inchi: InChI=1S/C8H16O2/c1-2-3-4-5-6-7-8(9)10/h2-7H2,1H3,(H,9,10)
 chemrof_inchikey: WWZKQHOCKIZLMA-UHFFFAOYSA-N
 cyclic_relationship: is_conjugate_acid_of CHEBI:25646


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octanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions ISO octanoic acid inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] CTD PMID:19428350 NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:229,648,501...229,665,232 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO octanoic acid results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:105,274,103...105,331,653
Ensembl chr13:105,282,440...105,295,750 		JBrowse link
G Casp1 caspase 1 increases phosphorylation ISO octanoic acid results in increased phosphorylation of CASP1 protein CTD PMID:30842373 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO [octanoic acid co-treated with Dexamethasone] results in increased expression of CAV1 protein; [SB 203580 results in decreased activity of MAPK14 protein] inhibits the reaction [[octanoic acid co-treated with Dexamethasone] results in increased expression of CAV1 protein] CTD PMID:14984747 NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740 		JBrowse link
G Cd86 CD86 molecule affects expression ISO octanoic acid affects the expression of CD86 protein CTD PMID:30842373 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:77,647,600...77,725,361 		JBrowse link
G Gna15 G protein subunit alpha 15 increases response to substance
multiple interactions 		ISO GNA15 protein results in increased susceptibility to octanoic acid
[GNA15 protein results in increased susceptibility to octanoic acid] which results in increased activity of OR51A5 protein; [GNA15 protein results in increased susceptibility to octanoic acid] which results in increased activity of OR55B4 protein 		CTD PMID:15598656 NCBI chr 7:8,835,396...8,856,269
Ensembl chr 7:8,835,357...8,856,268 		JBrowse link
G Icam1 intercellular adhesion molecule 1 affects expression ISO octanoic acid affects the expression of ICAM1 protein CTD PMID:30842373 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO octanoic acid results in increased expression of IL1B protein CTD PMID:30842373 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [SB 203580 results in decreased activity of MAPK14 protein] inhibits the reaction [[octanoic acid co-treated with Dexamethasone] results in increased expression of CAV1 protein]; [SB 203580 results in decreased activity of MAPK14 protein] inhibits the reaction [[octanoic acid co-treated with Dexamethasone] results in increased expression of PPARG protein alternative form] CTD PMID:14984747 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294 		JBrowse link
G Nefh neurofilament heavy chain affects expression EXP octanoic acid affects the expression of NEFH mRNA CTD PMID:22954530 NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions ISO octanoic acid binds to and results in increased activity of NR1H2 protein CTD PMID:16731579 NCBI chr 1:104,178,483...104,183,863
Ensembl chr 1:104,178,234...104,183,863 		JBrowse link
G Or51a41 olfactory receptor family 51 subfamily A member 41 multiple interactions ISO octanoic acid promotes the reaction [[pelargonic acid results in increased activity of OR51A5 protein] which results in increased abundance of Cyclic AMP]; octanoic acid promotes the reaction [pelargonic acid results in increased activity of OR51A5 protein]
[GNA15 protein results in increased susceptibility to octanoic acid] which results in increased activity of OR51A5 protein 		CTD PMID:15598656 NCBI chr 1:166,866,293...166,867,300
Ensembl chr 1:166,866,293...166,867,300 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
affects binding 		ISO octanoic acid binds to and results in increased activity of PPARA protein
octanoic acid binds to PPARA protein 		CTD PMID:16731579 PMID:35752307 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:118,712,412...118,780,714 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta multiple interactions ISO octanoic acid binds to and results in increased activity of PPARB protein CTD PMID:16731579 NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,352,183...6,365,707 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
affects binding 		ISO
EXP 		[octanoic acid co-treated with Dexamethasone] results in increased expression of PPARG protein alternative form; [SB 203580 results in decreased activity of MAPK14 protein] inhibits the reaction [[octanoic acid co-treated with Dexamethasone] results in increased expression of PPARG protein alternative form]
octanoic acid binds to PPARG protein 		CTD PMID:14984747 PMID:35752307 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions EXP octanoic acid inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A] CTD PMID:10336520 NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        antimicrobial agent 18216
          antibacterial agent 15366
            octanoic acid 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carbon oxoacid 17678
                                    carboxylic acid 17675
                                      monocarboxylic acid 17142
                                        fatty acid 14785
                                          saturated fatty acid 14672
                                            straight-chain saturated fatty acid 1340
                                              octanoic acid 16
paths to the root