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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:stigmasterol
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Accession:CHEBI:28824 term browser browse the term
Definition:A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.
Synonyms:exact_synonym: (22E)-stigmasta-5,22-dien-3beta-ol
 related_synonym: (3beta,22E)-stigmasta-5,22-dien-3-ol;   5,22-Cholestadien-24-ethyl-3beta-ol;   Formula=C29H48O;   InChI=1S/C29H48O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h8-10,19-21,23-27,30H,7,11-18H2,1-6H3/b9-8+/t20-,21-,23+,24+,25-,26+,27+,28+,29-/m1/s1;   InChIKey=HCXVJBMSMIARIN-PHZDYDNGSA-N;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)\\C=C\\[C@@H](CC)C(C)C;   beta-stigmasterol;   phytosterol;   poriferasterol;   stigmasta-5,22-dien-3beta-ol
 alt_id: CHEBI:26774;   CHEBI:8195
 xref: CAS:83-48-7;   HMDB:HMDB0000937;   KEGG:C05442;   KNApSAcK:C00003674;   KNApSAcK:C00023774;   LIPID_MAPS_instance:LMST01040123
 xref_mesh: MESH:D013265
 xref: PMID:13318319;   PMID:13547565;   Reaxys:2568182;   Wikipedia:Stigmasterol



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stigmasterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA] CTD PMID:30245210 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 multiple interactions
decreases expression
ISO [Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ABCG5 mRNA
Stigmasterol results in decreased expression of ABCG5 mRNA
CTD PMID:23454145 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 multiple interactions
decreases expression
ISO [Stigmasterol co-treated with Oligomycins] results in decreased expression of ABCG8 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ABCG8 mRNA
Stigmasterol results in decreased expression of ABCG8 mRNA
CTD PMID:23454145 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 multiple interactions ISO [Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of ACAT1 mRNA CTD PMID:23454145 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Ankrd1 ankyrin repeat domain 1 multiple interactions ISO [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of ANKRD1 mRNA CTD PMID:30245210 NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA]; Stigmasterol promotes the reaction [GW 4064 results in increased expression of APOA1 mRNA] CTD PMID:30245210 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Brinp3 BMP/retinoic acid inducible neural specific 3 multiple interactions ISO [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of BRINP3 mRNA CTD PMID:30245210 NCBI chr13:58,413,883...58,846,828
Ensembl chr13:58,413,883...58,846,770
JBrowse link
G Cldn11 claudin 11 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA] CTD PMID:30245210 NCBI chr 2:112,207,745...112,221,050
Ensembl chr 2:112,207,745...112,221,050
JBrowse link
G Dnmt3l DNA methyltransferase 3 like multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA] CTD PMID:30245210 NCBI chr20:10,614,933...10,629,337
Ensembl chr20:10,614,934...10,629,516
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA] CTD PMID:30245210 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions ISO Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of FSHR mRNA] CTD PMID:30245210 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G Gabarap GABA type A receptor-associated protein decreases expression ISO Stigmasterol results in decreased expression of GABARAP mRNA CTD PMID:30245210 NCBI chr10:54,714,777...54,718,099
Ensembl chr10:54,714,198...54,717,765
JBrowse link
G Gfra1 GDNF family receptor alpha 1 multiple interactions ISO [bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of GFRA1 mRNA] CTD PMID:30245210 NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases expression
ISO [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of HMGCR mRNA; [Stigmasterol co-treated with Oligomycins] results in decreased expression of HMGCR mRNA; [Stigmasterol co-treated with Rotenone] results in decreased expression of HMGCR mRNA
Stigmasterol results in increased expression of HMGCR mRNA
CTD PMID:23454145 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hoxa5 homeo box A5 multiple interactions ISO [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of HOXA5 mRNA CTD PMID:30245210 NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234
JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO Stigmasterol results in decreased expression of IFI35 mRNA CTD PMID:30245210 NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952
JBrowse link
G Il10 interleukin 10 increases secretion ISO Stigmasterol results in increased secretion of IL10 protein CTD PMID:23454145 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:23535395 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kng1 kininogen 1 multiple interactions ISO [Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in decreased expression of ACAT1 mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of HMGCR mRNA; [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of NPC1L1 mRNA CTD PMID:23454145 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555
JBrowse link
G Mybpc2 myosin binding protein C2 multiple interactions ISO [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of MYBPC2 mRNA CTD PMID:30245210 NCBI chr 1:94,994,121...95,017,584
Ensembl chr 1:94,994,104...95,017,584
JBrowse link
G Nanog Nanog homeobox decreases expression
multiple interactions
ISO Stigmasterol results in decreased expression of NANOG mRNA
[bisphenol A co-treated with Stigmasterol] results in decreased expression of NANOG mRNA; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of NANOG mRNA]
CTD PMID:30245210 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:23535395 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 multiple interactions ISO [Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of NPC1L1 mRNA; [Stigmasterol co-treated with Rotenone] results in increased expression of NPC1L1 mRNA CTD PMID:23454145 NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 multiple interactions
decreases expression
ISO [bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA; GW 4064 promotes the reaction [Stigmasterol results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of NR0B1 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of NR0B1 mRNA] CTD PMID:30245210 NCBI chr  X:50,756,886...50,761,014
Ensembl chr  X:50,756,886...50,761,011
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 multiple interactions ISO Stigmasterol promotes the reaction [GW 4064 results in increased expression of NR0B2 mRNA] CTD PMID:30245210 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
affects response to substance
decreases expression
ISO [bisphenol A co-treated with Stigmasterol] results in decreased expression of NR1H4 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of ANKRD1 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of BRINP3 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of HOXA5 mRNA; [NR1H4 gene mutant form affects the susceptibility to Stigmasterol] which results in decreased expression of MYBPC2 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of GFRA1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ABCB11 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of APOA1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of CLDN11 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of DNMT3L mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of ESR1 mRNA]; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in increased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of ZBTB16 mRNA]
Stigmasterol results in decreased expression of NR1H4 mRNA
CTD PMID:30245210 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:23535395 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rpl18a ribosomal protein L18A decreases expression ISO Stigmasterol results in decreased expression of RPL18A mRNA CTD PMID:30245210 NCBI chr16:18,542,555...18,544,578
Ensembl chr16:18,542,566...18,545,546
Ensembl chr 1:18,542,566...18,545,546
JBrowse link
G Rpl31 ribosomal protein L31 decreases expression ISO Stigmasterol results in decreased expression of RPL31 mRNA CTD PMID:30245210 NCBI chr 9:41,647,397...41,651,441
Ensembl chr 9:41,647,426...41,662,129
Ensembl chr 8:41,647,426...41,662,129
JBrowse link
G Rpl36 ribosomal protein L36 decreases expression ISO Stigmasterol results in decreased expression of RPL36 mRNA CTD PMID:30245210 NCBI chr 9:1,441,986...1,447,397
Ensembl chr 6:98,809,534...98,809,897
Ensembl chr 5:98,809,534...98,809,897
JBrowse link
G Rpph1 ribonuclease P RNA component H1 decreases expression ISO Stigmasterol results in decreased expression of RPPH1 mRNA CTD PMID:30245210 NCBI chr15:24,033,679...24,033,935
Ensembl chr15:24,033,662...24,033,959
JBrowse link
G Rps14 ribosomal protein S14 decreases expression ISO Stigmasterol results in decreased expression of RPS14 mRNA CTD PMID:30245210 NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166
JBrowse link
G Rps27 ribosomal protein S27 decreases expression ISO Stigmasterol results in decreased expression of RPS27 mRNA CTD PMID:30245210 NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964
Ensembl chr12:175,665,853...175,666,964
JBrowse link
G Rps7 ribosomal protein S7 decreases expression ISO Stigmasterol results in decreased expression of RPS7 mRNA CTD PMID:30245210 NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145
Ensembl chr 5:45,223,980...45,271,145
JBrowse link
G Stra8 stimulated by retinoic acid 8 decreases expression
multiple interactions
ISO Stigmasterol results in decreased expression of STRA8 mRNA
GW 4064 inhibits the reaction [Stigmasterol results in decreased expression of STRA8 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of STRA8 mRNA]
CTD PMID:30245210 NCBI chr 4:63,601,443...63,624,777
Ensembl chr 4:63,601,604...63,624,771
JBrowse link
G Tm2d3 TM2 domain containing 3 decreases expression ISO Stigmasterol results in decreased expression of TM2D3 mRNA CTD PMID:30245210 NCBI chr 1:119,267,194...119,277,094
Ensembl chr 1:119,264,576...119,277,099
JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
ISO Stigmasterol results in increased secretion of TNF protein
Stigmasterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:23454145 PMID:23535395 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Zbtb16 zinc finger and BTB domain containing 16 multiple interactions
decreases expression
ISO [bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA; NR1H4 gene mutant form inhibits the reaction [[bisphenol A co-treated with Stigmasterol] results in decreased expression of ZBTB16 mRNA]; NR1H4 gene mutant form inhibits the reaction [Stigmasterol results in decreased expression of ZBTB16 mRNA]; Stigmasterol inhibits the reaction [GW 4064 results in decreased expression of ZBTB16 mRNA] CTD PMID:30245210 NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        biochemical role 19549
          metabolite 19537
            eukaryotic metabolite 19362
              plant metabolite 17981
                stigmasterol 38
                  delta7-stigmasterol 0
                  stigmasterol 3-O-acetate 0
                  stigmasterol 3-O-beta-D-glucoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                organic polycyclic compound 17286
                                  steroid 14717
                                    steroid fundamental parent 14511
                                      stigmastane 39
                                        stigmastane derivative 38
                                          stigmastane sterol 38
                                            stigmasterol 38
                                              delta7-stigmasterol 0
                                              stigmasterol 3-O-acetate 0
                                              stigmasterol 3-O-beta-D-glucoside 0
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