CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: nitroglycerin
Accession: CHEBI:28787
browse the term
Definition: A nitroglycerol that is glycerol in which the hydrogen atoms of all three hydroxy groups are replaced by nitro groups. It acts as a prodrug, releasing nitric oxide to open blood vessels and so alleviate heart pain.
Synonyms: exact_synonym: 1,2,3-trinitrooxypropane
related_synonym: 1,2,3-propanetrioltrinitrate; 1,2,3-propanetriyl nitrate; Formula=C3H5N3O9; Glyceryl trinitrate; InChI=1S/C3H5N3O9/c7-4(8)13-1-3(15-6(11)12)2-14-5(9)10/h3H,1-2H2; InChIKey=SNIOPGDIGTZGOP-UHFFFAOYSA-N; Minitran; NG; Natispray; Nitro-Dur; Nitrolingual; Nitromist; Nitrostat; Rectogesic; SMILES=[O-][N+](=O)OCC(CO[N+]([O-])=O)O[N+]([O-])=O; Transderm Nitro; glycerin trinitrate; glycerol trinitrate; glycerol, nitric acid triester; nitroglycerine; nitroglycerol; propane-1,2,3-triyl trinitrate; trinitroglycerin; trinitroglycerol
alt_id: CHEBI:25559; CHEBI:7595
xref: CAS:55-63-0; DrugBank:DB00727; Drug_Central:1952; Gmelin:165859; KEGG:C07455; KEGG:D00515
xref_mesh: MESH:D005996
xref: PMID:11016328; PMID:11470751; PMID:11943517; PMID:22040938; PMID:22675243; PMID:23205544; PMID:23301717; PMID:9492718; Reaxys:1802063; UM-BBD_compID:c0061; Wikipedia:Glyceryl_trinitrate_(pharmacology); Wikipedia:Nitroglycerin
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Acat1
acetyl-CoA acetyltransferase 1
increases expression
EXP
Nitroglycerin results in increased expression of ACAT1 mRNA
CTD
PMID:12102619
NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
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Actb
actin, beta
decreases expression
EXP
Nitroglycerin results in decreased expression of ACTB mRNA
CTD
PMID:12102619
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
decreases expression
EXP
Nitroglycerin results in decreased expression of ALDH1A1 mRNA
CTD
PMID:12102619
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldh2
aldehyde dehydrogenase 2 family member
multiple interactions affects response to substance affects metabolic processing decreases activity decreases expression increases response to substance
ISO EXP
[1-aminocyclopropanol analog results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; [Cyanamide results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin; Acetylcysteine inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein]; ALDH2 protein affects the reaction [Nitroglycerin results in decreased abundance of Cyclic GMP] ALDH2 gene polymorphism affects the susceptibility to Nitroglycerin; ALDH2 protein affects the susceptibility to Nitroglycerin; ALDH2 protein polymorphism affects the susceptibility to Nitroglycerin ALDH2 protein affects the metabolism of Nitroglycerin ALDH2 protein affects the metabolism of and results in increased activity of Nitroglycerin; ALDH2 protein affects the reaction [Nitroglycerin results in increased abundance of Reactive Oxygen Species]; Hemin inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein] Nitroglycerin results in decreased expression of ALDH2 mRNA; Nitroglycerin results in decreased expression of ALDH2 protein ALDH2 protein results in increased susceptibility to Nitroglycerin ALDH2 protein affects the reaction [Ascorbic Acid deficiency results in decreased susceptibility to Nitroglycerin]
CTD
PMID:15331769 PMID:16440063 PMID:17092343 PMID:17493633 PMID:17541025 PMID:17585900 PMID:17967228 PMID:18272654 PMID:19576883 PMID:21156756 PMID:23194305 More...
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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Alox15
arachidonate 15-lipoxygenase
decreases expression
EXP
Nitroglycerin results in decreased expression of ALOX15 mRNA
CTD
PMID:12102619
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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Ap2m1
adaptor related protein complex 2 subunit mu 1
increases expression
EXP
Nitroglycerin results in increased expression of AP2M1 mRNA
CTD
PMID:12102619
NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
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Apex1
apurinic/apyrimidinic endodeoxyribonuclease 1
increases expression
EXP
Nitroglycerin results in increased expression of APEX1 mRNA
CTD
PMID:12102619
NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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Apoa1
apolipoprotein A1
decreases expression
EXP
Nitroglycerin results in decreased expression of APOA1 mRNA
CTD
PMID:12102619
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
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Arl2
ARF like GTPase 2
increases expression
EXP
Nitroglycerin results in increased expression of ARL2 mRNA
CTD
PMID:12102619
NCBI chr 1:203,434,129...203,446,156
Ensembl chr 1:203,434,129...203,446,119
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Atp5f1a
ATP synthase F1 subunit alpha
decreases expression
EXP
Nitroglycerin results in decreased expression of ATP5F1A mRNA
CTD
PMID:12102619
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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B2m
beta-2 microglobulin
affects expression
ISO
Nitroglycerin affects the expression of B2M protein
CTD
PMID:8350464
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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Bckdhb
branched chain keto acid dehydrogenase E1 subunit beta
decreases expression
EXP
Nitroglycerin results in decreased expression of BCKDHB mRNA
CTD
PMID:12102619
NCBI chr 8:84,845,264...85,027,812
Ensembl chr 8:84,845,264...85,027,812
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Bcl2
BCL2, apoptosis regulator
decreases expression
EXP
Nitroglycerin results in decreased expression of BCL2 protein
CTD
PMID:17678976
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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C3
complement C3
increases expression
ISO
Nitroglycerin results in increased expression of C3 protein alternative form
CTD
PMID:10884648
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Calca
calcitonin-related polypeptide alpha
multiple interactions affects expression increases expression
EXP ISO
Capsaicin inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Dexamethasone inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein]; Methylene Blue inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; NOS2 protein affects the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; pimagedine inhibits the reaction [Nitroglycerin results in increased expression of CALCA mRNA]; Plant Oils inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of CALCA protein] Nitroglycerin affects the expression of CALCA protein Nitroglycerin results in increased expression of CALCA mRNA; Nitroglycerin results in increased expression of CALCA protein
CTD
PMID:11919648 PMID:14659530 PMID:14729435 PMID:19121572 PMID:36924863
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Calm2
calmodulin 2
increases expression
EXP
Nitroglycerin results in increased expression of CALM2 mRNA
CTD
PMID:12102619
NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287 Ensembl chr15:7,091,567...7,104,287
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Capn2
calpain 2
decreases expression
EXP
Nitroglycerin results in decreased expression of CAPN2 mRNA
CTD
PMID:12102619
NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
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Casp1
caspase 1
multiple interactions
ISO
Nitroglycerin results in increased cleavage of and results in increased activity of CASP1 protein
CTD
PMID:12105852
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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Casp3
caspase 3
decreases expression multiple interactions
ISO
Nitroglycerin results in decreased expression of CASP3 protein modified form Nitroglycerin results in increased cleavage of and results in increased activity of CASP3 protein
CTD
PMID:12105852 PMID:17322376
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
EXP
Nitroglycerin results in increased expression of and results in increased activity of CAT protein
CTD
PMID:12860443 PMID:14732477
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cd3d
CD3 delta subunit of T-cell receptor complex
increases expression
EXP
Nitroglycerin results in increased expression of CD3D mRNA
CTD
PMID:12102619
NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809
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Cd5
Cd5 molecule
decreases expression
EXP
Nitroglycerin results in decreased expression of CD5 mRNA
CTD
PMID:12102619
NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313
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Cd53
Cd53 molecule
decreases expression
EXP
Nitroglycerin results in decreased expression of CD53 mRNA
CTD
PMID:12102619
NCBI chr 2:194,352,139...194,399,668
Ensembl chr 2:194,352,139...194,399,657
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Cdc37
cell division cycle 37, HSP90 cochaperone
increases expression
EXP
Nitroglycerin results in increased expression of CDC37 mRNA
CTD
PMID:12102619
NCBI chr 8:19,677,400...19,690,761
Ensembl chr 8:19,671,938...19,690,809
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
EXP
Nitroglycerin results in increased expression of CDKN1B mRNA
CTD
PMID:12102619
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Celf2
CUGBP, Elav-like family member 2
increases expression
EXP
Nitroglycerin results in increased expression of CELF2 mRNA
CTD
PMID:12102619
NCBI chr17:70,904,462...71,729,072
Ensembl chr17:71,210,853...71,728,333
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Ckb
creatine kinase B
decreases expression
EXP
Nitroglycerin results in decreased expression of CKB mRNA
CTD
PMID:12102619
NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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Clu
clusterin
decreases expression
EXP
Nitroglycerin results in decreased expression of CLU mRNA
CTD
PMID:12102619
NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
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Cnr1
cannabinoid receptor 1
multiple interactions
EXP
Nitroglycerin affects the reaction [glyceryl 2-arachidonate affects the activity of CNR1 protein]
CTD
PMID:16775503
NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
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Cp
ceruloplasmin
decreases expression
EXP
Nitroglycerin results in decreased expression of CP mRNA
CTD
PMID:12102619
NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
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Crip2
cysteine-rich protein 2
decreases expression
EXP
Nitroglycerin results in decreased expression of CRIP2 mRNA
CTD
PMID:12102619
NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065
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Ctnnb1
catenin beta 1
multiple interactions decreases localization
ISO
4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Nitroglycerin results in increased degradation of CTNNB1 protein]; Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; Nitroglycerin results in decreased phosphorylation of and results in increased nitrosation of and results in increased degradation of and results in decreased activity of CTNNB1 protein; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in decreased localization of CTNNB1 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin results in increased degradation of and results in decreased activity of CTNNB1 protein]
CTD
PMID:17030184
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Ctsd
cathepsin D
decreases expression
EXP
Nitroglycerin results in decreased expression of CTSD mRNA
CTD
PMID:12102619
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Cybb
cytochrome b-245 beta chain
multiple interactions decreases response to substance increases expression decreases expression
ISO EXP
CYBB gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]; Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA] CYBB gene mutant form results in decreased susceptibility to Nitroglycerin Nitroglycerin results in decreased expression of CYBB mRNA
CTD
PMID:16633368 PMID:17493633 PMID:18522491
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
decreases expression
EXP
Nitroglycerin results in decreased expression of CYP11B2 mRNA
CTD
PMID:12102619
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
affects expression decreases expression
EXP
Vitamin E inhibits the reaction [nitroglycerine decreases Cyp1a2 protein expression in rat heart] nitroglycerin decreased expression of Cyp1a2 protein in thoracic aorta of rats
RGD
PMID:16520233 PMID:12688525
RGD:401900296 , RGD:401900656
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2b15
cytochrome P450, family 2, subfamily b, polypeptide 15
decreases expression
EXP
Nitroglycerin results in decreased expression of CYP2B15 mRNA
CTD
PMID:12102619
NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
EXP
Nitroglycerin results in increased expression of CYP2E1 mRNA
CTD
PMID:12102619
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Dhcr7
7-dehydrocholesterol reductase
decreases expression
EXP
Nitroglycerin results in decreased expression of DHCR7 mRNA
CTD
PMID:12102619
NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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Dync1i1
dynein cytoplasmic 1 intermediate chain 1
decreases expression
EXP
Nitroglycerin results in decreased expression of DYNC1I1 mRNA
CTD
PMID:12102619
NCBI chr 4:33,852,597...34,166,159
Ensembl chr 4:33,852,927...34,166,149
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Dyrk1a
dual specificity tyrosine phosphorylation regulated kinase 1A
decreases expression
EXP
Nitroglycerin results in decreased expression of DYRK1A mRNA
CTD
PMID:12102619
NCBI chr11:33,890,706...34,009,420
Ensembl chr11:33,890,490...34,009,420
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Edn1
endothelin 1
decreases expression multiple interactions increases expression
ISO EXP
Nitroglycerin results in decreased expression of EDN1 mRNA Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein] Nitroglycerin results in decreased expression of EDN1 mRNA; Nitroglycerin results in decreased expression of EDN1 protein
CTD
PMID:11751199 PMID:12206003 PMID:12901495
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Elane
elastase, neutrophil expressed
increases expression
ISO
Nitroglycerin results in increased expression of ELANE protein
CTD
PMID:10884648
NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
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Eln
elastin
increases expression
EXP
Nitroglycerin results in increased expression of ELN mRNA
CTD
PMID:12187120
NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
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Faah
fatty acid amide hydrolase
increases activity multiple interactions
EXP
Nitroglycerin results in increased activity of FAAH protein Nitroglycerin promotes the reaction [FAAH protein results in increased chemical synthesis of Arachidonic Acid]; Nitroglycerin promotes the reaction [FAAH protein results in increased degradation of anandamide]
CTD
PMID:19515121
NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
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Fas
Fas cell surface death receptor
multiple interactions
ISO
Nitroglycerin results in increased expression of and results in increased localization of FAS protein
CTD
PMID:12105852
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fgfr2
fibroblast growth factor receptor 2
increases expression
EXP
Nitroglycerin results in increased expression of FGFR2 mRNA
CTD
PMID:12102619
NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
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Fmo1
flavin containing dimethylaniline monoxygenase 1
decreases expression
EXP
Nitroglycerin results in decreased expression of FMO1 mRNA
CTD
PMID:12102619
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression multiple interactions
ISO EXP
Nitroglycerin results in increased expression of FOS protein anandamide inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Ergotamine inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Plant Oils inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; Pregabalin inhibits the reaction [Nitroglycerin results in increased expression of FOS protein]; rizatriptan inhibits the reaction [Nitroglycerin results in increased expression of FOS mRNA]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of FOS mRNA] Nitroglycerin results in increased expression of FOS mRNA; Nitroglycerin results in increased expression of FOS protein
CTD
PMID:7552308 PMID:10426492 PMID:16897600 PMID:18761334 PMID:19121572 PMID:19489890 PMID:19515121 PMID:25290014 PMID:36924863 More...
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gchfr
GTP cyclohydrolase I feedback regulator
decreases expression
EXP
Nitroglycerin results in decreased expression of GCHFR mRNA
CTD
PMID:12102619
NCBI chr 3:106,158,046...106,162,080
Ensembl chr 3:106,159,394...106,162,080
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Gnb3
G protein subunit beta 3
affects response to substance
ISO
GNB3 protein affects the susceptibility to Nitroglycerin
CTD
PMID:14586390
NCBI chr 4:157,639,468...157,645,171
Ensembl chr 4:157,639,469...157,645,173
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Gng7
G protein subunit gamma 7
decreases expression
EXP
Nitroglycerin results in decreased expression of GNG7 mRNA
CTD
PMID:12102619
NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240
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Gpt
glutamic--pyruvic transaminase
multiple interactions
EXP
Nitroglycerin inhibits the reaction [cupric nitrilotriacetate results in increased activity of GPT protein]
CTD
PMID:36305384
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gpx1
glutathione peroxidase 1
decreases response to substance
ISO
GPX1 gene mutant form results in decreased susceptibility to Nitroglycerin
CTD
PMID:24296279
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Grk6
G protein-coupled receptor kinase 6
decreases expression
EXP
Nitroglycerin results in decreased expression of GRK6 mRNA
CTD
PMID:12102619
NCBI chr17:9,177,018...9,192,813
Ensembl chr17:9,177,019...9,192,644
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Grn
granulin precursor
decreases expression
EXP
Nitroglycerin results in decreased expression of GRN mRNA
CTD
PMID:12102619
NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
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Gsn
gelsolin
increases expression
EXP
Nitroglycerin results in increased expression of GSN mRNA
CTD
PMID:12187120
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
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Gsta2
glutathione S-transferase alpha 2
decreases expression
EXP
Nitroglycerin results in decreased expression of GSTA2 mRNA
CTD
PMID:12102619
NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
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Gsta3
glutathione S-transferase alpha 3
affects metabolic processing
EXP
GSTA3 protein affects the metabolism of Nitroglycerin
CTD
PMID:8968379
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
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Gstm2
glutathione S-transferase mu 2
affects metabolic processing
EXP
GSTM2 protein affects the metabolism of Nitroglycerin
CTD
PMID:8968379
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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Gtf3c1
general transcription factor IIIC subunit 1
increases expression
EXP
Nitroglycerin results in increased expression of GTF3C1 mRNA
CTD
PMID:12102619
NCBI chr 1:180,203,995...180,270,201
Ensembl chr 1:180,203,995...180,270,201
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Gucy1a1
guanylate cyclase 1 soluble subunit alpha 1
increases expression
EXP
Nitroglycerin results in increased expression of GUCY1A1 mRNA; Nitroglycerin results in increased expression of GUCY1A1 protein
CTD
PMID:11331261
NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
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Gucy1b1
guanylate cyclase 1 soluble subunit beta 1
increases expression
ISO EXP
Nitroglycerin results in increased expression of GUCY1B1 protein Nitroglycerin results in increased expression of GUCY1B1 mRNA; Nitroglycerin results in increased expression of GUCY1B1 protein
CTD
PMID:11331261 PMID:11742226 PMID:17541025
NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
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Hbb
hemoglobin subunit beta
increases expression
EXP
Nitroglycerin results in increased expression of HBB mRNA
CTD
PMID:12187120
NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
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Hdc
histidine decarboxylase
decreases expression
EXP
Nitroglycerin results in decreased expression of HDC mRNA
CTD
PMID:12102619
NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
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Hmox1
heme oxygenase 1
increases expression multiple interactions
ISO EXP
Nitroglycerin results in increased expression of HMOX1 mRNA [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 mRNA; [Hemin co-treated with Nitroglycerin] results in increased expression of HMOX1 protein
CTD
PMID:17092343 PMID:17470570 PMID:17541025
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hpn
hepsin
increases expression
EXP
Nitroglycerin results in increased expression of HPN mRNA
CTD
PMID:12102619
NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
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Iapp
islet amyloid polypeptide
increases expression
EXP
Nitroglycerin results in increased expression of IAPP mRNA
CTD
PMID:12102619
NCBI chr 4:175,237,107...175,244,373
Ensembl chr 4:175,237,115...175,242,920
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Id2
inhibitor of DNA binding 2
increases expression
EXP
Nitroglycerin results in increased expression of ID2 mRNA
CTD
PMID:12102619
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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Ido1
indoleamine 2,3-dioxygenase 1
decreases expression
EXP
Nitroglycerin results in decreased expression of IDO1 protein
CTD
PMID:28659861
NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
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Il1b
interleukin 1 beta
increases expression multiple interactions
EXP
Nitroglycerin results in increased expression of IL1B protein rizatriptan inhibits the reaction [Nitroglycerin results in increased expression of IL1B protein]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of IL1B protein]
CTD
PMID:11701602 PMID:36924863
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
increases expression
ISO EXP
Nitroglycerin results in increased expression of IL6 mRNA; Nitroglycerin results in increased expression of IL6 protein
CTD
PMID:11701602 PMID:17470570
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Jtb
jumping translocation breakpoint
increases expression
EXP
Nitroglycerin results in increased expression of JTB mRNA
CTD
PMID:12102619
NCBI chr 2:175,685,392...175,689,609
Ensembl chr 2:175,684,993...175,690,108
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Kmo
kynurenine 3-monooxygenase
decreases expression
EXP
Nitroglycerin results in decreased expression of KMO protein
CTD
PMID:28659861
NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881
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Kng2
kininogen 2
decreases expression
EXP
Nitroglycerin results in decreased expression of KNG2 mRNA
CTD
PMID:12102619
NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971
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Kynu
kynureninase
decreases expression
EXP
Nitroglycerin results in decreased expression of KYNU protein
CTD
PMID:28659861
NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488
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Maob
monoamine oxidase B
increases expression
EXP
Nitroglycerin results in increased expression of MAOB mRNA
CTD
PMID:12102619
NCBI chr X:5,907,327...6,010,996
Ensembl chr X:5,907,266...6,011,003
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Mecr
mitochondrial trans-2-enoyl-CoA reductase
decreases expression
EXP
Nitroglycerin results in decreased expression of MECR mRNA
CTD
PMID:12102619
NCBI chr 5:144,029,684...144,056,373
Ensembl chr 5:144,029,731...144,055,863
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Mgll
monoglyceride lipase
multiple interactions increases activity
EXP
Nitroglycerin promotes the reaction [MGLL protein results in increased chemical synthesis of Glycerol]; Nitroglycerin promotes the reaction [MGLL protein results in increased degradation of 2-oleoylglycerol] Nitroglycerin results in increased activity of MGLL protein
CTD
PMID:19515121
NCBI chr 4:121,192,186...121,294,187
Ensembl chr 4:121,192,195...121,294,179
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Mmp2
matrix metallopeptidase 2
increases expression
ISO
Nitroglycerin results in increased expression of MMP2 mRNA
CTD
PMID:12084592
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp7
matrix metallopeptidase 7
increases expression
ISO
Nitroglycerin results in increased expression of MMP7 mRNA
CTD
PMID:12084592
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
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Mmp9
matrix metallopeptidase 9
increases activity increases expression
ISO
Nitroglycerin results in increased activity of MMP9 protein Nitroglycerin results in increased expression of MMP9 mRNA
CTD
PMID:12084592
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpo
myeloperoxidase
decreases activity
EXP
Nitroglycerin results in decreased activity of MPO protein
CTD
PMID:8869312
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mxi1
MAX interactor 1, dimerization protein
increases expression
EXP
Nitroglycerin results in increased expression of MXI1 mRNA
CTD
PMID:12102619
NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681
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Myo9b
myosin IXb
decreases expression
EXP
Nitroglycerin results in decreased expression of MYO9B mRNA
CTD
PMID:12102619
NCBI chr16:17,945,379...18,030,114
Ensembl chr16:17,945,448...18,030,126
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Ncam1
neural cell adhesion molecule 1
increases expression
EXP
Nitroglycerin results in increased expression of NCAM1 mRNA
CTD
PMID:12102619
NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
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Ncf1
neutrophil cytosolic factor 1
decreases response to substance multiple interactions
ISO
NCF1 gene mutant form results in decreased susceptibility to Nitroglycerin NCF1 gene mutant form inhibits the reaction [Nitroglycerin results in decreased susceptibility to Acetylcholine]
CTD
PMID:18522491
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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Ndufa5
NADH:ubiquinone oxidoreductase subunit A5
decreases expression
EXP
Nitroglycerin results in decreased expression of NDUFA5 mRNA
CTD
PMID:12102619
NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598
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Nkx2-1
NK2 homeobox 1
decreases expression
EXP
Nitroglycerin results in decreased expression of NKX2-1 mRNA
CTD
PMID:12102619
NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791
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Nnat
neuronatin
increases expression
EXP
Nitroglycerin results in increased expression of NNAT mRNA
CTD
PMID:12102619
NCBI chr 3:146,225,941...146,228,868
Ensembl chr 3:146,226,407...146,228,834
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Nos1
nitric oxide synthase 1
multiple interactions increases expression
EXP
acetylsalicylic acid lysinate inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]; Sumatriptan inhibits the reaction [Nitroglycerin results in increased expression of NOS1 protein]
CTD
PMID:14510930 PMID:15154853
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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Nos2
nitric oxide synthase 2
decreases expression increases expression multiple interactions
ISO EXP
Nitroglycerin results in decreased expression of NOS2 mRNA Nitroglycerin results in decreased expression of NOS2 protein Nitroglycerin results in increased expression of NOS2 mRNA; Nitroglycerin results in increased expression of NOS2 protein NOS2 protein affects the reaction [Nitroglycerin results in increased expression of CALCA mRNA]
CTD
PMID:11701602 PMID:12206003 PMID:14729435 PMID:14732477
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nos3
nitric oxide synthase 3
multiple interactions increases expression
EXP
[Nitroglycerin co-treated with Hemin] results in increased expression of NOS3 mRNA; Nitroglycerin promotes the reaction [[Calcimycin results in increased activity of NOS3 protein] which results in increased abundance of Superoxides] Nitroglycerin results in increased expression of NOS3 mRNA; Nitroglycerin results in increased expression of NOS3 protein
CTD
PMID:10625313 PMID:12860443 PMID:14732477 PMID:17541025
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Nox1
NADPH oxidase 1
decreases expression
EXP
Nitroglycerin results in decreased expression of NOX1 mRNA
CTD
PMID:17493633
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
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Nox4
NADPH oxidase 4
decreases expression
EXP
Nitroglycerin results in decreased expression of NOX4 mRNA
CTD
PMID:17493633
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Npy
neuropeptide Y
increases expression
EXP
Nitroglycerin results in increased expression of NPY protein
CTD
PMID:10426492
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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Paics
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
increases expression
EXP
Nitroglycerin results in increased expression of PAICS mRNA
CTD
PMID:12102619
NCBI chr14:31,199,086...31,232,731
Ensembl chr14:31,173,541...31,232,635
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Parp1
poly (ADP-ribose) polymerase 1
decreases expression
ISO
Nitroglycerin results in decreased expression of PARP1 protein alternative form
CTD
PMID:17322376
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
decreases expression
EXP
Nitroglycerin results in decreased expression of PCSK1N mRNA
CTD
PMID:12102619
NCBI chr X:14,580,036...14,583,478
Ensembl chr X:14,580,038...14,583,566
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Pde1a
phosphodiesterase 1A
increases expression multiple interactions
EXP
Nitroglycerin results in increased expression of PDE1A mRNA; Nitroglycerin results in increased expression of PDE1A protein PDE1A protein inhibits the reaction [Nitroglycerin results in increased abundance of Cyclic GMP]
CTD
PMID:11696475
NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874
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Pde2a
phosphodiesterase 2A
increases expression
EXP
Nitroglycerin results in increased expression of PDE2A mRNA
CTD
PMID:12102619
NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434
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Pla2g1b
phospholipase A2 group IB
increases expression
EXP
Nitroglycerin results in increased expression of PLA2G1B mRNA
CTD
PMID:12102619
NCBI chr12:41,142,193...41,151,967
Ensembl chr12:41,142,200...41,153,226
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Plaur
plasminogen activator, urokinase receptor
increases expression
EXP
Nitroglycerin results in increased expression of PLAUR mRNA
CTD
PMID:12102619
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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Pmp22
peripheral myelin protein 22
decreases expression
EXP
Nitroglycerin results in decreased expression of PMP22 mRNA
CTD
PMID:12102619
NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714
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Polr1b
RNA polymerase I subunit B
increases expression
EXP
Nitroglycerin results in increased expression of POLR1B mRNA
CTD
PMID:12102619
NCBI chr 3:116,333,910...116,358,385
Ensembl chr 3:116,333,889...116,358,379
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Ppp2cb
protein phosphatase 2 catalytic subunit beta
decreases expression
EXP
Nitroglycerin results in decreased expression of PPP2CB mRNA
CTD
PMID:12102619
NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
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Prkg1
protein kinase cGMP-dependent 1
decreases expression
EXP
Nitroglycerin results in decreased expression of PRKG1 protein
CTD
PMID:11331261
NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
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Ptgds
prostaglandin D2 synthase
increases expression
EXP
Nitroglycerin results in increased expression of PTGDS mRNA
CTD
PMID:12102619
NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833
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Ptprr
protein tyrosine phosphatase, receptor type, R
increases expression
EXP
Nitroglycerin results in increased expression of PTPRR mRNA
CTD
PMID:12102619
NCBI chr 7:51,662,595...51,929,605
Ensembl chr 7:51,662,595...51,929,603
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Rab40c
Rab40c, member RAS oncogene family
increases expression
EXP
Nitroglycerin results in increased expression of RAB40C mRNA
CTD
PMID:12187120
NCBI chr10:14,900,926...14,936,153
Ensembl chr10:14,900,929...14,936,557
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Reg3b
regenerating family member 3 beta
increases expression
EXP
Nitroglycerin results in increased expression of REG3B mRNA
CTD
PMID:12102619
NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
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Rela
RELA proto-oncogene, NF-kB subunit
increases localization multiple interactions increases expression
EXP
Nitroglycerin results in increased localization of RELA protein Atorvastatin inhibits the reaction [Nitroglycerin results in increased localization of RELA protein]; Nitroglycerin results in increased expression of and results in increased phosphorylation of RELA protein; rizatriptan inhibits the reaction [Nitroglycerin results in increased expression of and results in increased phosphorylation of RELA protein]; rizatriptan inhibits the reaction [Nitroglycerin results in increased expression of RELA mRNA]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of and results in increased phosphorylation of RELA protein]; yufengningxin inhibits the reaction [Nitroglycerin results in increased expression of RELA mRNA]
CTD
PMID:19733216 PMID:36924863
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Ren
renin
increases activity
ISO
Nitroglycerin results in increased activity of REN protein
CTD
PMID:9527094
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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Rgs8
regulator of G-protein signaling 8
increases expression
EXP
Nitroglycerin results in increased expression of RGS8 mRNA
CTD
PMID:12102619
NCBI chr13:65,804,703...65,848,955
Ensembl chr13:65,804,797...65,846,807
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Rheb
Ras homolog, mTORC1 binding
decreases expression
EXP
Nitroglycerin results in decreased expression of RHEB mRNA
CTD
PMID:12102619
NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160
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Rpl6
ribosomal protein L6
decreases expression
EXP
Nitroglycerin results in decreased expression of RPL6 mRNA
CTD
PMID:12102619
NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
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Rps3a
ribosomal protein S3a
increases expression
EXP
Nitroglycerin results in increased expression of RPS3A mRNA
CTD
PMID:12102619
NCBI chr 2:171,524,685...171,529,054
Ensembl chr 2:171,524,500...171,529,055
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Scgb1a1
secretoglobin family 1A member 1
decreases expression
EXP
Nitroglycerin results in decreased expression of SCGB1A1 mRNA
CTD
PMID:12102619
NCBI chr 1:205,977,060...205,980,610
Ensembl chr 1:205,977,060...205,980,610
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Sdc4
syndecan 4
decreases expression
EXP
Nitroglycerin results in decreased expression of SDC4 mRNA
CTD
PMID:12102619
NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
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Serpina3n
serpin family A member 3N
decreases expression
EXP
Nitroglycerin results in decreased expression of SERPINA3N mRNA
CTD
PMID:12102619
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
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Shank2
SH3 and multiple ankyrin repeat domains 2
increases expression
EXP
Nitroglycerin results in increased expression of SHANK2 mRNA
CTD
PMID:12102619
NCBI chr 1:199,146,210...199,590,962
Ensembl chr 1:199,169,429...199,589,394
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Slc4a4
solute carrier family 4 member 4
increases expression
EXP
Nitroglycerin results in increased expression of SLC4A4 mRNA
CTD
PMID:12102619
NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883
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Snn
stannin
decreases expression
EXP
Nitroglycerin results in decreased expression of SNN mRNA
CTD
PMID:12102619
NCBI chr10:4,572,933...4,581,606
Ensembl chr10:4,572,376...4,584,021
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Snrk
SNF related kinase
increases expression
EXP
Nitroglycerin results in increased expression of SNRK mRNA
CTD
PMID:12102619
NCBI chr 8:121,779,704...121,833,949
Ensembl chr 8:121,793,302...121,832,323
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Sod2
superoxide dismutase 2
multiple interactions
EXP
Nitroglycerin results in increased expression of and results in increased activity of SOD2 protein
CTD
PMID:12860443 PMID:14732477
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Stat3
signal transducer and activator of transcription 3
increases expression
EXP
Nitroglycerin results in increased expression of STAT3 mRNA
CTD
PMID:12102619
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Syk
spleen associated tyrosine kinase
increases expression
EXP
Nitroglycerin results in increased expression of SYK mRNA
CTD
PMID:12102619
NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410
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Syn2
synapsin II
increases expression
EXP
Nitroglycerin results in increased expression of SYN2 mRNA
CTD
PMID:12102619
NCBI chr 4:148,178,846...148,347,010
Ensembl chr 4:148,186,270...148,344,192
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Tac1
tachykinin, precursor 1
affects expression
EXP
Nitroglycerin affects the expression of TAC1 protein
CTD
PMID:18197882
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tcf4
transcription factor 4
multiple interactions
ISO
Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Nitroglycerin inhibits the reaction [CTNNB1 protein binds to TCF4 protein]]
CTD
PMID:17030184
NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425
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Tdo2
tryptophan 2,3-dioxygenase
decreases expression
EXP
Nitroglycerin results in decreased expression of TDO2 protein
CTD
PMID:28659861
NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
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Thy1
Thy-1 cell surface antigen
decreases expression
EXP
Nitroglycerin results in decreased expression of THY1 mRNA
CTD
PMID:12102619
NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
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Tmpo
thymopoietin
increases expression
EXP
Nitroglycerin results in increased expression of TMPO mRNA
CTD
PMID:12102619
NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727
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Tnf
tumor necrosis factor
decreases expression multiple interactions
ISO EXP
Nitroglycerin results in decreased expression of TNF protein Capsaicin inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein]; Methylene Blue inhibits the reaction [Nitroglycerin results in decreased expression of TNF protein]
CTD
PMID:10884648 PMID:11744139
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf8
TNF receptor superfamily member 8
decreases expression
EXP
Nitroglycerin results in decreased expression of TNFRSF8 mRNA
CTD
PMID:12102619
NCBI chr 5:157,123,183...157,168,421
Ensembl chr 5:157,123,185...157,168,421
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Umod
uromodulin
increases expression
EXP
Nitroglycerin results in increased expression of UMOD mRNA
CTD
PMID:12102619
NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302
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Vasp
vasodilator-stimulated phosphoprotein
multiple interactions decreases phosphorylation increases phosphorylation
ISO EXP
1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein] Benomyl inhibits the reaction [Nitroglycerin results in increased phosphorylation of VASP protein]; Hemin inhibits the reaction [Nitroglycerin results in decreased phosphorylation of VASP protein]
CTD
PMID:11331261 PMID:14551241 PMID:15331769 PMID:17541025 PMID:17868048 PMID:20129490 More...
NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
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Vtn
vitronectin
increases expression
EXP
Nitroglycerin results in increased expression of VTN mRNA
CTD
PMID:12102619
NCBI chr10:63,394,732...63,397,812
Ensembl chr10:63,394,719...63,397,810
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Ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
decreases expression
EXP
Nitroglycerin results in decreased expression of YWHAZ mRNA
CTD
PMID:12102619
NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668
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