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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2,4,6-trichlorophenol
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Accession:CHEBI:28755 term browser browse the term
Definition:A trichlorophenol with phenolic substituents on positions 2, 4 and 6.
Synonyms:related_synonym: 1,3,5-Trichloro-2-hydroxybenzene;   2,4,6-TCP;   Formula=C6H3Cl3O;   InChI=1S/C6H3Cl3O/c7-3-1-4(8)6(10)5(9)2-3/h1-2,10H;   InChIKey=LINPIYWFGCPVIE-UHFFFAOYSA-N;   SMILES=Oc1c(Cl)cc(Cl)cc1Cl
 alt_id: CHEBI:19334;   CHEBI:898
 xref: CAS:88-06-2;   Gmelin:3766;   KEGG:C07098
 xref_mesh: MESH:C024564
 xref: MetaCyc:TRICHLOROPHENOL;   PDBeChem:T6C;   PMID:21863115;   PMID:22748215;   PMID:23995979;   PMID:24078273;   Reaxys:776729;   UM-BBD_compID:c0330;   Wikipedia:2\,4\,6-Trichlorophenol
 cyclic_relationship: is_conjugate_acid_of CHEBI:140426


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2,4,6-trichlorophenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alkbh5 alkB homolog 5, RNA demethylase increases expression ISO 2,4,6-trichlorophenol results in increased expression of ALKBH5 mRNA CTD PMID:38157273 NCBI chr10:45,344,888...45,366,331
Ensembl chr10:45,343,395...45,366,331 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO 2,4,6-trichlorophenol results in decreased expression of CYP11A1 mRNA CTD PMID:21296122 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO 2,4,6-trichlorophenol results in decreased expression of CYP19A1 mRNA CTD PMID:21296122 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 increases methylation ISO 2,4,6-trichlorophenol results in increased methylation of EIF2AK2 3' UTR CTD PMID:38157273 NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase increases expression ISO 2,4,6-trichlorophenol results in increased expression of FTO mRNA CTD PMID:38157273 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 decreases expression ISO 2,4,6-trichlorophenol results in decreased expression of HSD17B4 mRNA CTD PMID:21296122 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO 2,4,6-trichlorophenol results in decreased expression of HSD3B1 mRNA CTD PMID:21296122 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Mettl14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit increases expression ISO 2,4,6-trichlorophenol results in increased expression of METTL14 mRNA CTD PMID:38157273 NCBI chr 2:211,530,598...211,546,845
Ensembl chr 2:211,530,602...211,546,821 		JBrowse link
G Mettl3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit increases expression ISO 2,4,6-trichlorophenol results in increased expression of METTL3 mRNA
2,4,6-trichlorophenol results in increased expression of METTL3 protein		 CTD PMID:38157273 NCBI chr15:25,002,505...25,014,097
Ensembl chr15:25,003,172...25,014,041 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects binding ISO 2,4,6-trichlorophenol binds to PPARG protein CTD PMID:25314719 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Rxrb retinoid X receptor beta multiple interactions ISO 2,4,6-trichlorophenol inhibits the reaction [alitretinoin binds to and results in increased activity of RXRB protein] CTD PMID:27565853 NCBI chr20:4,816,813...4,823,267
Ensembl chr20:4,816,815...4,828,773 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO 2,4,6-trichlorophenol results in decreased expression of STAR mRNA CTD PMID:21296122 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO 2,4,6-trichlorophenol inhibits the reaction [Triiodothyronine binds to THRB protein] CTD PMID:29409039 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Wtap WT1 associated protein increases expression ISO 2,4,6-trichlorophenol results in increased expression of WTAP mRNA; 2,4,6-trichlorophenol results in increased expression of WTAP protein CTD PMID:38157273 NCBI chr 1:47,665,965...47,691,067
Ensembl chr 1:47,665,965...47,691,065 		JBrowse link
G Ythdf2 YTH N6-methyladenosine RNA binding protein F2 increases expression ISO 2,4,6-trichlorophenol results in increased expression of YTHDF2 mRNA CTD PMID:38157273 NCBI chr 5:144,381,426...144,407,126
Ensembl chr 5:144,381,431...144,408,144 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        aetiopathogenetic role 19217
          carcinogenic agent 18525
            2,4,6-trichlorophenol 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            organic molecule 19700
                              organic cyclic compound 19490
                                carbocyclic compound 18579
                                  benzenoid aromatic compound 18003
                                    benzenes 17868
                                      chlorobenzenes 15043
                                        chlorophenol 1214
                                          trichlorophenols 25
                                            trichlorophenol 25
                                              2,4,6-trichlorophenol 15
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