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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:S-butyl-DL-homocysteine (S,R)-sulfoximine
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Accession:CHEBI:28714 term browser browse the term
Definition:A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.
Synonyms:related_synonym: (2RS)-2-amino-4-(S-butylsulfonimidoyl)butanoic acid;   (2RS)-2-amino-4-(S-butylsulfonimidoyl)butyric acid;   DL-butathionine-(S,R)-sulfoximine;   DL-buthionine sulfoximine;   Formula=C8H18N2O3S;   InChI=1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12);   InChIKey=KJQFBVYMGADDTQ-UHFFFAOYSA-N;   SMILES=CCCCS(=N)(=O)CCC(N)C(O)=O;   buthionine sulfoximine;   buthionine sulphoximine
 alt_id: CHEBI:22039;   CHEBI:8953
 xref: Beilstein:236716;   CAS:5072-26-4;   KEGG:C04543;   LINCS:LSM-36606
 xref_mesh: MESH:D019328
 xref: PMID:27008382;   PMID:27764704;   PMID:29127710;   PMID:31302132;   PMID:32965035;   PMID:34036678;   Wikipedia:Buthionine_sulfoximine


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S-butyl-DL-homocysteine (S,R)-sulfoximine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 affects localization
multiple interactions		 ISO Buthionine Sulfoximine affects the localization of ABCC1 protein mutant form
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to arsenite]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to monomethylarsonous acid analog]; Buthionine Sulfoximine analog inhibits the reaction [Acetylcysteine promotes the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]]; Buthionine Sulfoximine inhibits the reaction [ABCC1 protein results in decreased susceptibility to Vincristine]; Buthionine Sulfoximine inhibits the reaction [ABCC1 results in decreased susceptibility to arsenite]; Buthionine Sulfoximine inhibits the reaction [ABCC1 results in decreased susceptibility to methylarsine analog]		 CTD PMID:15180633 PMID:15473893 PMID:15581632 PMID:21918036 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Acin1 apoptotic chromatin condensation inducer 1 increases expression EXP Buthionine Sulfoximine results in increased expression of ACIN1 protein CTD PMID:23736079 NCBI chr15:28,102,112...28,147,001
Ensembl chr15:28,102,112...28,147,001 		JBrowse link
G Actb actin, beta decreases expression ISO Buthionine Sulfoximine results in decreased expression of ACTB mRNA CTD PMID:15878706 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877 		JBrowse link
G Add3 adducin 3 increases expression ISO Buthionine Sulfoximine results in increased expression of ADD3 mRNA CTD PMID:15878706 NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124 		JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide multiple interactions EXP Buthionine Sulfoximine promotes the reaction [Ethanol results in increased expression of ADH1 mRNA] CTD PMID:20705415 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892 		JBrowse link
G Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 increases expression ISO Buthionine Sulfoximine results in increased expression of AIMP1 mRNA CTD PMID:15878706 NCBI chr 2:221,151,907...221,175,458
Ensembl chr 2:221,151,904...221,175,728 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium results in increased phosphorylation of AKT1 protein]
Buthionine Sulfoximine promotes the reaction [arsenite results in increased phosphorylation of AKT1 protein]		 CTD PMID:24449419 PMID:36343453 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alad aminolevulinate dehydratase decreases activity EXP Buthionine Sulfoximine results in decreased activity of ALAD protein CTD PMID:21620807 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [1,2,4-trichlorobenzene results in increased activity of ALAS1 protein] CTD PMID:11996131 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Alb albumin multiple interactions EXP [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of ALB mRNA CTD PMID:23288050 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Buthionine Sulfoximine results in increased expression of ALDOA mRNA; Buthionine Sulfoximine results in increased expression of ALDOA protein CTD PMID:11841787 PMID:23736079 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182 		JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor multiple interactions EXP [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of AMBP mRNA CTD PMID:23288050 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331 		JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Buthionine Sulfoximine results in increased expression of APEX1 protein CTD PMID:23736079 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Apoh apolipoprotein H multiple interactions EXP [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of APOH mRNA CTD PMID:23288050 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329 		JBrowse link
G App amyloid beta precursor protein multiple interactions EXP (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate inhibits the reaction [[ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in decreased expression of SYP protein]; (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate inhibits the reaction [[ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased expression of GFAP protein]; (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate inhibits the reaction [[ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased phosphorylation of MAPT protein]; [ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in decreased expression of SYP protein; [ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased expression of GFAP protein; [ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased phosphorylation of MAPT protein CTD PMID:19850110 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator decreases expression ISO Buthionine Sulfoximine results in decreased expression of ARNT protein CTD PMID:16880289 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta increases expression ISO Buthionine Sulfoximine results in increased expression of ATP5F1B mRNA CTD PMID:15878706 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273 		JBrowse link
G Atxn1 ataxin 1 affects localization
multiple interactions		 ISO Buthionine Sulfoximine affects the localization of ATXN1 protein mutant form
Buthionine Sulfoximine promotes the reaction [Hydrogen Peroxide affects the localization of ATXN1 protein mutant form]; Buthionine Sulfoximine promotes the reaction [tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form]		 CTD PMID:12893416 NCBI chr17:18,737,491...19,142,360
Ensembl chr17:18,737,533...19,142,360 		JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO Buthionine Sulfoximine results in increased expression of AXL mRNA CTD PMID:15878706 NCBI chr 1:81,265,088...81,296,278
Ensembl chr 1:81,265,088...81,296,265 		JBrowse link
G Azin1 antizyme inhibitor 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of AZIN1 mRNA CTD PMID:15878706 NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Cadmium Chloride co-treated with Buthionine Sulfoximine] results in decreased expression of BAX protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in decreased expression of BAX protein] CTD PMID:11341981 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO
EXP		 Buthionine Sulfoximine results in decreased expression of BCL2 mRNA
Buthionine Sulfoximine promotes the reaction [cyanoginosin LR results in decreased expression of BCL2 protein]
[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[Cadmium Chloride co-treated with Buthionine Sulfoximine] results in increased expression of BCL2 protein]
Sodium Selenite promotes the reaction [Buthionine Sulfoximine results in decreased expression of BCL2 mRNA]		 CTD PMID:11341981 PMID:17989939 PMID:25410294 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bmp1 bone morphogenetic protein 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of BMP1 mRNA CTD PMID:15878706 NCBI chr15:45,551,603...45,595,862
Ensembl chr15:45,551,603...45,595,776 		JBrowse link
G Calr calreticulin increases expression EXP Buthionine Sulfoximine results in increased expression of CALR protein CTD PMID:23736079 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 ISO
EXP		 4-amylcinnamoylanthranilic acid inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP3 protein]; Sodium Selenite promotes the reaction [Buthionine Sulfoximine results in increased expression of CASP3 mRNA]
[O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate co-treated with Buthionine Sulfoximine] results in increased cleavage of CASP3 protein; Buthionine Sulfoximine promotes the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased activity of CASP3 protein]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of and results in increased cleavage of CASP3 protein]; Buthionine Sulfoximine results in increased expression of and results in increased cleavage of CASP3 protein
[Buthionine Sulfoximine co-treated with Arsenic Trioxide] results in increased activity of CASP3 protein; [monomethylarsonic acid co-treated with Buthionine Sulfoximine] results in increased activity of CASP3 protein; Buthionine Sulfoximine inhibits the reaction [Cacodylic Acid results in increased activity of CASP3 protein]; Buthionine Sulfoximine promotes the reaction [Vitamin K 3 results in increased activity of CASP3 protein]		 CTD PMID:10673743 PMID:15276415 PMID:15963344 PMID:16310883 PMID:17200146 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp4 caspase 4 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased activity of CASP4 protein] CTD PMID:25341683 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Casp7 caspase 7 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate affects the cleavage of CASP7 protein] CTD PMID:20962031 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Buthionine Sulfoximine co-treated with arsenic trioxide] results in increased cleavage of CASP8 protein; pyrazolanthrone inhibits the reaction [[Buthionine Sulfoximine co-treated with arsenic trioxide] results in increased cleavage of CASP8 protein] CTD PMID:17145888 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO 4-amylcinnamoylanthranilic acid inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP9 protein]; Glutathione inhibits the reaction [Buthionine Sulfoximine results in increased activity of CASP9 protein] CTD PMID:33309544 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 EXP
ISO		 Buthionine Sulfoximine results in decreased activity of CAT protein
Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of CAT protein]; CAT inhibits the reaction [Buthionine Sulfoximine results in decreased abundance of Glutathione]; CAT inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]; CAT inhibits the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]; CD36 mRNA promotes the reaction [CAT inhibits the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]]; Plant Extracts inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of CAT protein]]		 CTD PMID:21620807 PMID:21772021 PMID:26187465 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of CCL11 mRNA CTD PMID:22407903 PMID:27421576 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression		 ISO
EXP		 [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of CCL2 mRNA; [Troglitazone co-treated with Buthionine Sulfoximine] results in increased expression of CCL2 mRNA; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of CCL2 mRNA]
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CCL2 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CCL2 mRNA]		 CTD PMID:22407903 PMID:26177832 PMID:31294483 PMID:35123994 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]] CTD PMID:11167962 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of CCND1 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of CCND1 protein] CTD PMID:17602960 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Cd163 CD163 molecule multiple interactions EXP [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA] CTD PMID:26177832 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878 		JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions		 ISO Buthionine Sulfoximine results in increased expression of CD36 protein
[pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of CD36 mRNA; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]; CAT inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]; CD36 mRNA promotes the reaction [Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]]; CD36 mRNA promotes the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]; CD36 mRNA promotes the reaction [CAT inhibits the reaction [Buthionine Sulfoximine results in increased uptake of malondialdehyde-low density lipoprotein, human]]; PPARG mRNA promotes the reaction [Tamoxifen inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]]; Tamoxifen inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]		 CTD PMID:26187465 PMID:27358406 PMID:28263783 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd59b CD59b molecule increases mutagenesis ISO Buthionine Sulfoximine results in increased mutagenesis of CD59 gene CTD PMID:15033018 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847 		JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA] CTD PMID:26177832 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Cd86 CD86 molecule increases expression ISO Buthionine Sulfoximine results in increased expression of CD86 protein CTD PMID:20457211 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of CDKN1A protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1A protein] CTD PMID:17602960 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of CDKN1B protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of CDKN1B protein] CTD PMID:17602960 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [potassium chromate(VI) results in increased expression of CHEK2 protein modified form] CTD PMID:25977998 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Cherp calcium homeostasis endoplasmic reticulum protein increases expression EXP Buthionine Sulfoximine results in increased expression of CHERP protein CTD PMID:23736079 NCBI chr16:17,367,455...17,380,507
Ensembl chr16:17,367,455...17,380,507 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of COL1A1 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of COL1A1 protein] CTD PMID:17602960 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO Buthionine Sulfoximine promotes the reaction [CYP2E1 protein results in increased expression of COL1A2 mRNA] CTD PMID:10498651 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Col5a3 collagen type V alpha 3 chain decreases expression ISO Buthionine Sulfoximine results in decreased expression of COL5A3 mRNA CTD PMID:15878706 NCBI chr 8:19,304,564...19,349,809
Ensembl chr 8:19,304,571...19,349,853 		JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 increases expression ISO Buthionine Sulfoximine results in increased expression of COX4I1 mRNA CTD PMID:15878706 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921 		JBrowse link
G Crebbp CREB binding protein multiple interactions EXP [Buthionine Sulfoximine results in increased phosphorylation of STAT3 protein] promotes the reaction [CREBBP protein results in increased acetylation of STAT3 protein modified form] CTD PMID:19289167 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888 		JBrowse link
G Cse1l chromosome segregation 1 like increases expression EXP Buthionine Sulfoximine results in increased expression of CSE1L protein CTD PMID:23736079 NCBI chr 3:155,641,104...155,678,866
Ensembl chr 3:155,641,166...155,678,865 		JBrowse link
G Csf1 colony stimulating factor 1 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of CSF1 mRNA] CTD PMID:35123994 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL1 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL1 mRNA] CTD PMID:26177832 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression
increases expression
multiple interactions		 ISO Buthionine Sulfoximine results in decreased expression of CXCL12 mRNA
Buthionine Sulfoximine results in increased expression of CXCL12 mRNA
Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of CXCL12 mRNA]		 CTD PMID:15878706 PMID:35123994 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO
EXP		 [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; [Troglitazone co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA; Alprostadil inhibits the reaction [[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of CXCL2 mRNA]
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL2 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL2 mRNA]		 CTD PMID:23986454 PMID:26177832 PMID:27421576 PMID:28263783 PMID:31294483 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075 		JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO [Troglitazone co-treated with Buthionine Sulfoximine] results in increased expression of CXCL1 mRNA; Buthionine Sulfoximine promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of CXCL1 protein] CTD PMID:26149495 PMID:31294483 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Buthionine Sulfoximine results in decreased expression of CXCR4 mRNA CTD PMID:15878706 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases activity		 ISO
EXP		 Buthionine Sulfoximine affects the reaction [Curcumin affects the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]]; Buthionine Sulfoximine promotes the reaction [sodium arsenite inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]
Buthionine Sulfoximine results in decreased activity of CYP1A1 protein
Buthionine Sulfoximine results in increased activity of CYP1A1 protein
[Buthionine Sulfoximine co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; [Buthionine Sulfoximine co-treated with Cadmium Chloride] results in increased expression of CYP1A1 mRNA; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of CYP1A1 mRNA; Buthionine Sulfoximine inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased activity of CYP1A1 protein]; Buthionine Sulfoximine promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [chromium trioxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [chromium trioxide results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; Buthionine Sulfoximine promotes the reaction [Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; Buthionine Sulfoximine promotes the reaction [Lead results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]]; Buthionine Sulfoximine promotes the reaction [sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of CYP1A1 mRNA]; Buthionine Sulfoximine promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Buthionine Sulfoximine inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Buthionine Sulfoximine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]		 CTD PMID:9756946 PMID:16274885 PMID:16906435 PMID:18078826 PMID:19033395 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases response to substance
multiple interactions		 ISO CYP2E1 protein results in increased susceptibility to Buthionine Sulfoximine; CYP2E1 results in increased susceptibility to Buthionine Sulfoximine
Buthionine Sulfoximine promotes the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein]; Buthionine Sulfoximine promotes the reaction [CYP2E1 protein results in increased expression of COL1A2 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin promotes the reaction [CYP2E1 protein results in increased susceptibility to Buthionine Sulfoximine]; Zinc Sulfate inhibits the reaction [CYP2E1 results in increased susceptibility to Buthionine Sulfoximine]		 CTD PMID:10498651 PMID:12086689 PMID:12566070 PMID:22486562 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione; Buthionine Sulfoximine promotes the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]; neferine promotes the reaction [[CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione] CTD PMID:25451576 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dab1 DAB adaptor protein 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of DAB1 mRNA CTD PMID:15878706 NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552 		JBrowse link
G Dars1 aspartyl-tRNA synthetase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of DARS1 protein CTD PMID:23736079 NCBI chr13:39,857,936...39,913,055
Ensembl chr13:39,857,936...39,913,116 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of DDIT3 protein] CTD PMID:17171638 PMID:25341683 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 decreases expression EXP Buthionine Sulfoximine results in decreased expression of DGAT2 mRNA CTD PMID:20482862 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428 		JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Colforsin results in increased activity of DIO2 protein] CTD PMID:18420745 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809 		JBrowse link
G Dio3 iodothyronine deiodinase 3 increases activity EXP Buthionine Sulfoximine results in increased activity of DIO3 protein CTD PMID:18420745 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660 		JBrowse link
G Dld dihydrolipoamide dehydrogenase increases expression EXP Buthionine Sulfoximine results in increased expression of DLD protein CTD PMID:23736079 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
decreases expression		 EXP sulforaphane inhibits the reaction [Buthionine Sulfoximine results in decreased expression of DRD1 protein] CTD PMID:23876469 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression ISO Buthionine Sulfoximine results in increased expression of ECH1 mRNA CTD PMID:15878706 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases expression ISO Buthionine Sulfoximine results in increased expression of EEF1A1 mRNA CTD PMID:15878706 NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839 		JBrowse link
G Eef1b2 eukaryotic translation elongation factor 1 beta 2 increases expression ISO Buthionine Sulfoximine results in increased expression of EEF1B2 mRNA CTD PMID:15878706 NCBI chr 9:64,580,163...64,582,737
Ensembl chr 9:64,579,893...64,582,737 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO Buthionine Sulfoximine promotes the reaction [arsenite results in increased expression of and results in increased secretion of EGF protein] CTD PMID:36343453 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of EGR1 mRNA] CTD PMID:19010381 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Eif1a eukaryotic translation initiation factor 1A decreases expression ISO Buthionine Sulfoximine results in decreased expression of EIF1A mRNA CTD PMID:15878706 NCBI chr18:39,325,695...39,338,043
Ensembl chr18:39,325,202...39,338,696 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased phosphorylation of EIF2AK3 protein] CTD PMID:25341683 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2b4 eukaryotic translation initiation factor 2B subunit delta decreases expression ISO Buthionine Sulfoximine results in decreased expression of EIF2B4 mRNA CTD PMID:15878706 NCBI chr 6:25,183,177...25,188,832
Ensembl chr 6:25,183,186...25,188,829 		JBrowse link
G Eif3g eukaryotic translation initiation factor 3, subunit G decreases expression ISO Buthionine Sulfoximine results in decreased expression of EIF3G mRNA CTD PMID:15878706 NCBI chr 8:19,429,728...19,433,760
Ensembl chr 8:19,429,643...19,433,808 		JBrowse link
G Esyt1 extended synaptotagmin 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of ESYT1 mRNA CTD PMID:15878706 NCBI chr 7:928,848...946,199
Ensembl chr 7:928,848...946,199 		JBrowse link
G Etf1 eukaryotic translation termination factor 1 increases expression ISO Buthionine Sulfoximine results in increased expression of ETF1 mRNA CTD PMID:15707499 NCBI chr18:26,502,413...26,530,753
Ensembl chr18:26,504,080...26,530,810 		JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit decreases expression ISO Buthionine Sulfoximine results in decreased expression of EZH1 mRNA CTD PMID:15878706 NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Copper deficiency results in increased expression of FAS mRNA] CTD PMID:9227460 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FASL mRNA CTD PMID:23986454 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression EXP Buthionine Sulfoximine results in increased expression of FKBP5 protein CTD PMID:23736079 NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 increases expression ISO Buthionine Sulfoximine results in increased expression of FLT1 mRNA CTD PMID:15878706 NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [FMO3 protein results in increased susceptibility to Thiourea] CTD PMID:12093470 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028 		JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein] CTD PMID:19524604 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO
EXP		 Buthionine Sulfoximine inhibits the reaction [Sodium Selenite results in increased expression of FOS mRNA]; Buthionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Glucosamine analog inhibits the reaction [Buthionine Sulfoximine results in increased expression of FOS mRNA] CTD PMID:7743507 PMID:15520183 PMID:18449455 PMID:21825963 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions ISO
EXP		 Buthionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]
Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of FOSL1 mRNA]		 CTD PMID:15520183 PMID:19010381 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930 		JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO
EXP		 [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of FOXP3 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of FOXP3 mRNA		 CTD PMID:23986454 PMID:26177832 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
increases expression		 ISO Buthionine Sulfoximine promotes the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of FTH1 mRNA]
Buthionine Sulfoximine results in increased expression of FTH1 mRNA		 CTD PMID:15878706 PMID:16631525 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression EXP Buthionine Sulfoximine results in increased expression of G6PD mRNA CTD PMID:12717738 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions
increases expression		 ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone binds to GAPDH protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone results in decreased activity of GAPDH protein]
Buthionine Sulfoximine results in increased expression of GAPDH mRNA		 CTD PMID:15878706 PMID:21827172 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gata3 GATA binding protein 3 multiple interactions
decreases expression		 ISO
EXP		 [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of GATA3 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of GATA3 mRNA
Buthionine Sulfoximine results in decreased expression of GATA3 mRNA		 CTD PMID:22407903 PMID:23986454 PMID:26177832 PMID:27421576 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gc GC, vitamin D binding protein multiple interactions EXP [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of GC mRNA CTD PMID:23288050 NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases activity
decreases expression
increases expression
multiple interactions
decreases activity		 ISO
EXP		 Buthionine Sulfoximine results in increased activity of GCLC protein
Buthionine Sulfoximine results in decreased expression of GCLC protein
Buthionine Sulfoximine results in increased expression of GCLC mRNA
[Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione]; [Buthionine Sulfoximine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [Thiabendazole co-treated with Buthionine Sulfoximine] results in increased activity of GCLC protein; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of GCLC mRNA]; Buthionine Sulfoximine inhibits the reaction [GCLC protein results in decreased susceptibility to naphthalene]; Buthionine Sulfoximine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]; Buthionine Sulfoximine inhibits the reaction [naphthalene results in increased activity of GCLC protein]; Buthionine Sulfoximine promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of GCLC mRNA]
Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]; Buthionine Sulfoximine inhibits the reaction [GCLC results in decreased susceptibility to Cadmium Chloride]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in decreased expression of GCLC protein]
[Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GCLC protein; [Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GCLC protein; Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of GCLC mRNA]; Buthionine Sulfoximine inhibits the reaction [GCLC protein results in increased chemical synthesis of gamma-glutamylcysteine]; Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in increased expression of GCLC mRNA]		 CTD PMID:7955076 PMID:10900227 PMID:10915739 PMID:10978506 PMID:11019651 More... NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions		 EXP
ISO		 Buthionine Sulfoximine results in increased expression of GCLM mRNA
Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione]
[Buthionine Sulfoximine results in decreased activity of [GCLC protein binds to GCLM protein]] inhibits the reaction [chrysin inhibits the reaction [tert-Butylhydroperoxide results in increased chemical synthesis of Reactive Oxygen Species]]		 CTD PMID:10978506 PMID:17724089 PMID:19010381 PMID:22864849 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression
multiple interactions		 ISO Buthionine Sulfoximine results in increased expression of GDF15 mRNA
Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of GDF15 mRNA]		 CTD PMID:35123994 NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055 		JBrowse link
G Gdi2 GDP dissociation inhibitor 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of GDI2 mRNA CTD PMID:15878706 NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate inhibits the reaction [[ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased expression of GFAP protein]; [ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased expression of GFAP protein CTD PMID:19850110 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Glrx glutaredoxin multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [arsenite results in increased expression of GLRX protein] CTD PMID:36343453 NCBI chr 2:5,341,873...5,351,686
Ensembl chr 2:5,341,885...5,351,680 		JBrowse link
G Gmfb glia maturation factor, beta increases response to substance ISO GMFB protein results in increased susceptibility to Buthionine Sulfoximine CTD PMID:12791701 NCBI chr15:20,069,923...20,081,005
Ensembl chr15:20,067,263...20,080,331 		JBrowse link
G Gpi glucose-6-phosphate isomerase increases expression ISO Buthionine Sulfoximine results in increased expression of GPI1 mRNA CTD PMID:15878706 NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO		 [allyl sulfide co-treated with dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate] inhibits the reaction [[Carbon Tetrachloride co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein]; [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of GPT protein; [Carbon Tetrachloride co-treated with Buthionine Sulfoximine] results in increased expression of and results in increased activity of GPT protein; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of GPT protein]; Ursodeoxycholic Acid inhibits the reaction [[Carbon Tetrachloride co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein]
[Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of GPT protein; [Methimazole co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein; [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of GPT protein; Buthionine Sulfoximine promotes the reaction [[Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein]; Tranylcypromine inhibits the reaction [[Methimazole co-treated with Buthionine Sulfoximine] results in increased activity of GPT protein]		 CTD PMID:15950962 PMID:26177832 PMID:27421576 PMID:29679711 PMID:30853469 More... NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx1 glutathione peroxidase 1 affects activity
multiple interactions		 ISO
EXP		 Buthionine Sulfoximine affects the activity of GPX1 protein
Buthionine Sulfoximine promotes the reaction [Microcystins analog results in increased expression of GPX1 mRNA]
Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of GPX1 mRNA]		 CTD PMID:15707499 PMID:24964298 PMID:25341683 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression ISO Buthionine Sulfoximine results in increased expression of GPX2 mRNA CTD PMID:15878706 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877 		JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression ISO Buthionine Sulfoximine results in increased expression of GPX3 mRNA CTD PMID:15878706 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Acrolein results in decreased expression of GPX4 mRNA] CTD PMID:33421550 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of GRB2 mRNA CTD PMID:15878706 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Gsn gelsolin increases expression ISO Buthionine Sulfoximine results in increased expression of GSN mRNA CTD PMID:15878706 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP		 Buthionine Sulfoximine inhibits the reaction [schizandrin B results in increased activity of GSR protein]; Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Cyclophosphamide results in decreased activity of GSR protein]]
Buthionine Sulfoximine inhibits the reaction [arsenite results in increased activity of GSR protein]
[Buthionine Sulfoximine co-treated with Carmustine] results in decreased activity of GSR protein; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of GSR protein; [cyanoginosin LR co-treated with Buthionine Sulfoximine] results in increased activity of GSR protein; Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in decreased expression of GSR mRNA]; Buthionine Sulfoximine inhibits the reaction [schizandrin B results in increased activity of GSR protein]; Buthionine Sulfoximine promotes the reaction [Arsenic Trioxide results in increased expression of GSR mRNA]		 CTD PMID:12967637 PMID:16288907 PMID:17119269 PMID:21772021 PMID:24634002 More... NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gss glutathione synthetase decreases activity
increases expression		 EXP Buthionine Sulfoximine results in decreased activity of GSS protein
Buthionine Sulfoximine results in increased expression of GSS mRNA		 CTD PMID:10904027 PMID:10978506 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198 		JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of GSTA1 mRNA] CTD PMID:9152014 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 increases expression ISO Buthionine Sulfoximine results in increased expression of GSTM1 mRNA CTD PMID:15878706 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression ISO Buthionine Sulfoximine results in increased expression of GSTM2 mRNA CTD PMID:15878706 NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO
EXP		 Buthionine Sulfoximine inhibits the reaction [GSTP1 results in decreased susceptibility to Benzo(a)pyrene]
Buthionine Sulfoximine inhibits the reaction [Microcystins analog results in increased expression of GSTP1 mRNA]		 CTD PMID:19330882 PMID:24964298 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase increases expression ISO Buthionine Sulfoximine results in increased expression of HADH mRNA CTD PMID:15878706 NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353 		JBrowse link
G Hbs1l HBS1-like translational GTPase decreases expression ISO Buthionine Sulfoximine results in decreased expression of HBS1L mRNA CTD PMID:15878706 NCBI chr 1:16,092,529...16,170,082
Ensembl chr 1:16,092,547...16,170,074 		JBrowse link
G Hdgf heparin binding growth factor increases expression ISO Buthionine Sulfoximine results in increased expression of HDGF mRNA CTD PMID:15878706 NCBI chr 2:173,370,147...173,379,756
Ensembl chr 2:173,370,465...173,379,747 		JBrowse link
G Hgf hepatocyte growth factor increases expression EXP Buthionine Sulfoximine results in increased expression of HGF protein CTD PMID:9763232 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases activity		 ISO
EXP		 Buthionine Sulfoximine promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of HIF1A protein]
Buthionine Sulfoximine results in increased activity of HIF1A protein		 CTD PMID:11641398 PMID:11841787 PMID:17658243 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO
EXP		 [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of HMGB1 protein
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein]		 CTD PMID:23986454 PMID:26177832 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmgb2 high mobility group box 2 increases expression ISO Buthionine Sulfoximine results in increased expression of HMGB2 mRNA CTD PMID:15707499 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO
EXP		 1-aminobenzotriazole inhibits the reaction [[Acetaminophen co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Butylated Hydroxyanisole co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Diclofenac co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 1-aminobenzotriazole inhibits the reaction [[Ticlopidine co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; [2-tert-butylhydroquinone co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA; [Buthionine Sulfoximine co-treated with Ascorbic Acid] promotes the reaction [Copper Sulfate results in increased expression of HMOX1 mRNA]; [Buthionine Sulfoximine co-treated with Dehydroascorbic Acid] promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA; [monocrystalline iron oxide nanoparticle co-treated with Buthionine Sulfoximine co-treated with Dehydroascorbic Acid] results in increased expression of HMOX1 mRNA; [monocrystalline iron oxide nanoparticle co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA; Buthionine Sulfoximine promotes the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Acetaminophen results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Butylated Hydroxyanisole results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Copper Sulfate results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [cupric oxide results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Ticlopidine results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]
Buthionine Sulfoximine results in increased expression of HMOX1 protein
Buthionine Sulfoximine results in increased expression of HMOX1 mRNA; Buthionine Sulfoximine results in increased expression of HMOX1 protein
[Buthionine Sulfoximine co-treated with sulforaphane] results in increased expression of HMOX1 protein; [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of HMOX1 mRNA; Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]
[6-formylindolo(3,2-b)carbazole co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA; [Buthionine Sulfoximine co-treated with Gefitinib] results in increased expression of HMOX1 mRNA; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA; [Troglitazone co-treated with Buthionine Sulfoximine] results in increased expression of HMOX1 mRNA; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [[Cadmium Chloride co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [[chromium trioxide co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [[sodium arsenite co-treated with Tetrachlorodibenzodioxin] results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [chromium trioxide results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased expression of HMOX1 protein]; Buthionine Sulfoximine promotes the reaction [Lead results in increased expression of HMOX1 mRNA]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of HMOX1 protein]		 CTD PMID:7626009 PMID:9152014 PMID:11841787 PMID:12763371 PMID:16274885 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hmox2 heme oxygenase 2 affects response to substance ISO HMOX2 affects the susceptibility to Buthionine Sulfoximine CTD PMID:16181104 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148 		JBrowse link
G Hnrnpm heterogeneous nuclear ribonucleoprotein M increases expression EXP Buthionine Sulfoximine results in increased expression of HNRNPM protein CTD PMID:23736079 NCBI chr 7:14,438,703...14,476,781
Ensembl chr 7:14,438,688...14,476,762 		JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP Buthionine Sulfoximine results in increased expression of HSP90AA1 protein CTD PMID:23736079 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression ISO Buthionine Sulfoximine results in increased expression of HSP90AB1 mRNA CTD PMID:15707499 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 increases expression EXP Buthionine Sulfoximine results in increased expression of HSPA4 protein CTD PMID:23736079 NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of HSPA5 protein] CTD PMID:25341683 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO
EXP		 Buthionine Sulfoximine results in increased expression of HSPA8 mRNA CTD PMID:7626009 PMID:15707499 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression		 ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Buthionine Sulfoximine results in increased expression of ICAM1 protein]]; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Tetradecanoylphorbol Acetate promotes the reaction [Buthionine Sulfoximine results in increased expression of ICAM1 protein]
[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of ICAM1 mRNA		 CTD PMID:11164475 PMID:20116392 PMID:20351055 PMID:29154782 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions EXP Buthionine Sulfoximine affects the reaction [ID2 protein binds to MYC promoter] CTD PMID:19289167 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [INS1 protein results in decreased expression of IGFBP1 mRNA] CTD PMID:17213664 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP		 Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; Buthionine Sulfoximine promotes the reaction [methyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]]
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL10 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL10 mRNA]		 CTD PMID:19339665 PMID:26177832 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein]; Buthionine Sulfoximine inhibits the reaction [methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]] CTD PMID:12688424 PMID:19339665 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL17A protein CTD PMID:23986454 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of IL1A mRNA; LY6G protein affects the reaction [[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of IL1A mRNA] CTD PMID:29154782 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion		 EXP
ISO		 [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL1B mRNA; Acetylcysteine inhibits the reaction [[Buthionine Sulfoximine co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of IL1B protein]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
[Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL1B mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of IL1B protein; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Buthionine Sulfoximine promotes the reaction [hydroxyethyl methacrylate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; Buthionine Sulfoximine promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of IL1B protein]		 CTD PMID:11970852 PMID:12433058 PMID:23986454 PMID:26149495 PMID:26177832 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL23A mRNA CTD PMID:23986454 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of IL4 protein; Buthionine Sulfoximine promotes the reaction [Methimazole results in increased expression of IL4 protein] CTD PMID:22407903 PMID:27421576 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions		 EXP
ISO		 Buthionine Sulfoximine results in increased secretion of IL6 protein
[Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA; [Troglitazone co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Buthionine Sulfoximine inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Buthionine Sulfoximine inhibits the reaction [methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL6 mRNA; Acetylcysteine inhibits the reaction [[Buthionine Sulfoximine co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of IL6 protein]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL6 mRNA]		 CTD PMID:11970852 PMID:12433058 PMID:15601679 PMID:19339665 PMID:23986454 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [INS1 protein results in decreased expression of IGFBP1 mRNA] CTD PMID:17213664 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Jak1 Janus kinase 1 increases expression ISO Buthionine Sulfoximine results in increased expression of JAK1 mRNA CTD PMID:15878706 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Jak2 Janus kinase 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of JAK2 mRNA CTD PMID:15878706 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases activity		 ISO
EXP		 Buthionine Sulfoximine inhibits the reaction [Sodium Selenite results in increased expression of JUN mRNA]; Buthionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Buthionine Sulfoximine promotes the reaction [Trioxsalen analog results in decreased activity of JUN protein]; Glucosamine analog inhibits the reaction [Buthionine Sulfoximine results in increased expression of JUN mRNA]
Buthionine Sulfoximine inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]
Buthionine Sulfoximine results in decreased activity of JUN protein		 CTD PMID:7626009 PMID:7743507 PMID:11341981 PMID:11841787 PMID:11849044 More... NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of JUNB mRNA] CTD PMID:15520183 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 multiple interactions EXP [Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCNA4 protein CTD PMID:16288907 NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162 		JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 multiple interactions EXP [Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCND2 mRNA; [Carmustine co-treated with Buthionine Sulfoximine] results in decreased expression of KCND2 protein CTD PMID:16288907 NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione] CTD PMID:19608619 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [KLF4 results in decreased susceptibility to Cisplatin] CTD PMID:21833590 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Klf6 KLF transcription factor 6 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [[CYP2E1 protein co-treated with Vitamin K 3] results in increased expression of KLF6 protein] CTD PMID:22486562 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570 		JBrowse link
G Kpnb1 karyopherin subunit beta 1 increases expression EXP Buthionine Sulfoximine results in increased expression of KPNB1 protein CTD PMID:23736079 NCBI chr10:82,145,662...82,174,437
Ensembl chr10:82,145,420...82,174,605 		JBrowse link
G Lcn2 lipocalin 2 increases expression
multiple interactions		 EXP
ISO		 Buthionine Sulfoximine results in increased expression of LCN2 mRNA
[Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of LCN2 mRNA; [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of LCN2 mRNA; [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA; LY6G protein affects the reaction [[zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of LCN2 mRNA]
Diclofenac promotes the reaction [Buthionine Sulfoximine results in increased expression of LCN2 mRNA]		 CTD PMID:23939143 PMID:29154782 PMID:29679711 PMID:30853469 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of LEF1 protein CTD PMID:27421576 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing increases expression EXP Buthionine Sulfoximine results in increased expression of LRPPRC protein CTD PMID:23736079 NCBI chr 6:9,859,816...9,942,294
Ensembl chr 6:9,859,867...9,942,293 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
multiple interactions		 ISO Buthionine Sulfoximine results in increased expression of MAP1LC3B protein; Buthionine Sulfoximine results in increased expression of MAP1LC3B protein modified form
Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of MAP1LC3B protein]; Cadmium Chloride promotes the reaction [Buthionine Sulfoximine results in increased expression of MAP1LC3B protein]		 CTD PMID:34580807 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO		 [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK1 protein; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; Buthionine Sulfoximine promotes the reaction [chromium hexavalent ion results in increased activity of MAPK1 protein]; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK1 protein]
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK1 protein; [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK1 protein; Buthionine Sulfoximine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK1 protein]; Buthionine Sulfoximine promotes the reaction [arsenite results in increased phosphorylation of MAPK1 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; Buthionine Sulfoximine results in decreased expression of and results in increased phosphorylation of MAPK1 protein; Cadmium Chloride promotes the reaction [Buthionine Sulfoximine results in decreased expression of and results in increased phosphorylation of MAPK1 protein]		 CTD PMID:8616849 PMID:17191120 PMID:21971136 PMID:24401988 PMID:26177832 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk11 mitogen-activated protein kinase 11 decreases expression
multiple interactions		 ISO Buthionine Sulfoximine results in decreased expression of MAPK11 mRNA
Sodium Selenite inhibits the reaction [Buthionine Sulfoximine results in decreased expression of MAPK11 mRNA]		 CTD PMID:17989939 NCBI chr 7:120,218,471...120,225,488
Ensembl chr 7:120,218,478...120,225,395 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO Buthionine Sulfoximine results in increased phosphorylation of MAPK14 protein CTD PMID:17191120 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO		 [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK3 protein; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Buthionine Sulfoximine promotes the reaction [chromium hexavalent ion results in increased activity of MAPK3 protein]; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK3 protein]
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK3 protein; [ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in decreased phosphorylation of MAPK3 protein; Buthionine Sulfoximine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of MAPK3 protein]; Buthionine Sulfoximine promotes the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; Buthionine Sulfoximine results in decreased expression of and results in increased phosphorylation of MAPK3 protein; Cadmium Chloride promotes the reaction [Buthionine Sulfoximine results in decreased expression of and results in increased phosphorylation of MAPK3 protein]		 CTD PMID:8616849 PMID:17191120 PMID:21971136 PMID:24401988 PMID:26177832 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [antimony trioxide co-treated with Buthionine Sulfoximine] results in decreased expression of MAPK8 protein; Buthionine Sulfoximine promotes the reaction [antimony trioxide results in increased activity of MAPK8 protein]; Buthionine Sulfoximine promotes the reaction [Arsenic Trioxide results in increased activity of MAPK8 protein]; Buthionine Sulfoximine promotes the reaction [arsenite results in increased phosphorylation of MAPK8 protein] CTD PMID:14701702 PMID:16112521 PMID:36343453 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases phosphorylation ISO Buthionine Sulfoximine results in decreased phosphorylation of MAPK9 protein CTD PMID:17191120 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate inhibits the reaction [[ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased phosphorylation of MAPT protein]; [ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased phosphorylation of MAPT protein CTD PMID:19850110 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Mars1 methionyl-tRNA synthetase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of MARS1 protein CTD PMID:23736079 NCBI chr 7:63,121,142...63,138,550
Ensembl chr 7:63,121,142...63,138,495 		JBrowse link
G Mb myoglobin multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased secretion of MB protein CTD PMID:29679711 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383 		JBrowse link
G Mef2a myocyte enhancer factor 2a increases expression ISO Buthionine Sulfoximine results in increased expression of MEF2A mRNA CTD PMID:15878706 NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase multiple interactions
decreases activity		 ISO Buthionine Sulfoximine inhibits the reaction [MGMT protein results in increased susceptibility to Mitomycin]
Buthionine Sulfoximine results in decreased activity of MGMT protein		 CTD PMID:16039682 PMID:16950796 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756 		JBrowse link
G Mir101-2 microRNA 101-2 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR101B mRNA CTD PMID:27421576 NCBI chr 1:226,860,371...226,860,467
Ensembl chr 1:226,860,371...226,860,467 		JBrowse link
G Mir106b microRNA 106b multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR106B mRNA CTD PMID:27421576 NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425 		JBrowse link
G Mir127 microRNA 127 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR127 mRNA CTD PMID:27421576 NCBI chr 6:128,546,215...128,546,311
Ensembl chr 6:128,546,215...128,546,311 		JBrowse link
G Mir133b microRNA 133b multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR133B mRNA; [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR133B mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of MIR133B mRNA CTD PMID:28263783 PMID:29679711 PMID:30853469 NCBI chr 9:23,098,134...23,098,217
Ensembl chr 9:23,098,134...23,098,217 		JBrowse link
G Mir136 microRNA 136 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR136 mRNA CTD PMID:27421576 NCBI chr 6:128,549,096...128,549,177
Ensembl chr 6:128,549,096...128,549,177 		JBrowse link
G Mir137 microRNA 137 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR137 mRNA CTD PMID:27421576 NCBI chr 2:206,480,881...206,480,982
Ensembl chr 2:206,480,884...206,480,985 		JBrowse link
G Mir138-1 microRNA 138-1 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR138-1 mRNA CTD PMID:27421576 NCBI chr 8:122,300,966...122,301,064
Ensembl chr 8:122,300,966...122,301,064 		JBrowse link
G Mir141 microRNA 141 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR141 mRNA CTD PMID:27421576 NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332 		JBrowse link
G Mir148b microRNA 148b multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR148B mRNA CTD PMID:27421576 NCBI chr 7:134,421,398...134,421,494
Ensembl chr 7:134,421,398...134,421,494 		JBrowse link
G Mir151 microRNA 151 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR151 mRNA CTD PMID:27421576 NCBI chr 7:105,172,377...105,172,473 JBrowse link
G Mir184 microRNA 184 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR184 mRNA CTD PMID:27421576 NCBI chr 8:90,343,134...90,343,210
Ensembl chr 8:90,343,134...90,343,210 		JBrowse link
G Mir187 microRNA 187 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR187 mRNA; [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR187 mRNA CTD PMID:27421576 NCBI chr18:15,731,194...15,731,297
Ensembl chr18:15,731,194...15,731,297 		JBrowse link
G Mir188 microRNA 188 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR188 mRNA CTD PMID:27421576 NCBI chr  X:15,247,715...15,247,794
Ensembl chr  X:15,247,715...15,247,794 		JBrowse link
G Mir190 microRNA 190 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR190A mRNA CTD PMID:27421576 NCBI chr 8:67,850,987...67,851,071
Ensembl chr 8:67,850,987...67,851,071 		JBrowse link
G Mir19a microRNA 19a multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR19A mRNA CTD PMID:27421576 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993 		JBrowse link
G Mir200a microRNA 200a multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR200A mRNA CTD PMID:27421576 NCBI chr 5:166,648,494...166,648,582 JBrowse link
G Mir206 microRNA 206 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR206 mRNA; [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of MIR206 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of MIR206 mRNA CTD PMID:28263783 PMID:29679711 PMID:30853469 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Mir20b microRNA 20b multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR20B mRNA CTD PMID:27421576 NCBI chr  X:132,422,211...132,422,282
Ensembl chr  X:132,422,211...132,422,282 		JBrowse link
G Mir210 microRNA 210 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR210 mRNA CTD PMID:27421576 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
G Mir211 microRNA 211 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR211 mRNA CTD PMID:27421576 NCBI chr 1:117,777,539...117,777,644
Ensembl chr 1:117,777,539...117,777,644 		JBrowse link
G Mir224 microRNA 224 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR224 mRNA CTD PMID:27421576 NCBI chr  X:150,065,088...150,065,169
Ensembl chr  X:150,065,088...150,065,169 		JBrowse link
G Mir29b1 microRNA 29b-1 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR29B-1 mRNA CTD PMID:27421576 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir322 microRNA 322 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR322 mRNA; [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR322 mRNA CTD PMID:27421576 NCBI chr  X:132,806,594...132,806,688
Ensembl chr  X:132,806,594...132,806,688 		JBrowse link
G Mir324 microRNA 324 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR324 mRNA CTD PMID:27421576 NCBI chr10:54,734,680...54,734,762
Ensembl chr10:54,734,678...54,734,766 		JBrowse link
G Mir328 microRNA 328 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR328 mRNA CTD PMID:27421576 NCBI chr19:33,184,766...33,184,849
Ensembl chr19:33,184,766...33,184,849 		JBrowse link
G Mir337 microRNA 337 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR337 mRNA CTD PMID:27421576 NCBI chr 6:128,538,903...128,538,999
Ensembl chr 6:128,538,902...128,538,998 		JBrowse link
G Mir339 microRNA 339 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR339 mRNA CTD PMID:27421576 NCBI chr12:15,277,546...15,277,641
Ensembl chr12:15,277,546...15,277,641 		JBrowse link
G Mir34b microRNA 34b multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR34B mRNA CTD PMID:27421576 NCBI chr 8:51,410,244...51,410,327
Ensembl chr 8:51,410,244...51,410,327 		JBrowse link
G Mir361 microRNA 361 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR361 mRNA CTD PMID:27421576 NCBI chr  X:78,246,206...78,246,275
Ensembl chr  X:78,246,206...78,246,275 		JBrowse link
G Mir375 microRNA 375 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR375 mRNA CTD PMID:27421576 NCBI chr 9:76,457,911...76,457,985
Ensembl chr 9:76,457,911...76,457,985 		JBrowse link
G Mir410 microRNA 410 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR410 mRNA CTD PMID:27421576 NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434 		JBrowse link
G Mir449a microRNA 449a multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR449A mRNA; [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR449A mRNA CTD PMID:27421576 NCBI chr 2:44,670,714...44,670,804
Ensembl chr 2:44,670,714...44,670,804 		JBrowse link
G Mir450a1 microRNA 450a-1 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR450A1 mRNA CTD PMID:27421576 NCBI chr  X:132,801,380...132,801,470
Ensembl chr  X:132,801,380...132,801,470 		JBrowse link
G Mir455 microRNA 455 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR455 mRNA CTD PMID:27421576 NCBI chr 5:76,689,313...76,689,390
Ensembl chr 5:76,689,313...76,689,390 		JBrowse link
G Mir671 microRNA 671 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR671 mRNA CTD PMID:27421576 NCBI chr 4:10,580,747...10,580,827
Ensembl chr 4:10,580,738...10,580,835 		JBrowse link
G Mir99a microRNA 99a multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of MIR99A mRNA CTD PMID:27421576 NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO [Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA] CTD PMID:10464329 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of MPO protein CTD PMID:26177832 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mrps7 mitochondrial ribosomal protein S7 increases expression ISO Buthionine Sulfoximine results in increased expression of MRPS7 mRNA CTD PMID:15878706 NCBI chr10:100,843,691...100,846,838
Ensembl chr10:100,843,356...100,847,129 		JBrowse link
G Mt1 metallothionein 1 increases expression
increases activity
multiple interactions		 EXP
ISO		 Buthionine Sulfoximine results in increased expression of MT1A mRNA
Buthionine Sulfoximine results in increased activity of MT1 promoter
Buthionine Sulfoximine promotes the reaction [Copper results in increased activity of MT1 promoter]; Buthionine Sulfoximine promotes the reaction [Paraquat results in increased expression of MT1 mRNA]; Dactinomycin inhibits the reaction [Buthionine Sulfoximine promotes the reaction [Paraquat results in increased expression of MT1 mRNA]]
Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of MT1A mRNA]		 CTD PMID:7626009 PMID:8966720 PMID:9152014 PMID:14576086 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr  X:10,826,032...10,827,049 		JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [Buthionine Sulfoximine co-treated with Gefitinib] results in increased expression of MT2 mRNA CTD PMID:32741899 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions
decreases response to substance		 ISO MTF1 results in decreased susceptibility to [Buthionine Sulfoximine co-treated with cadmium sulfate]
MTF1 results in decreased susceptibility to Buthionine Sulfoximine		 CTD PMID:16221973 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]] CTD PMID:26989453 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Buthionine Sulfoximine affects the reaction [ID2 protein binds to MYC promoter]; Buthionine Sulfoximine affects the reaction [SIN3A protein binds to MYC promoter]; Buthionine Sulfoximine promotes the reaction [STAT3 protein modified form binds to MYC promoter] CTD PMID:19289167 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of NARS1 protein CTD PMID:23736079 NCBI chr18:57,989,308...58,005,584
Ensembl chr18:57,989,308...58,005,622 		JBrowse link
G Ndn necdin, MAGE family member increases expression ISO Buthionine Sulfoximine results in increased expression of NDN mRNA CTD PMID:15878706 NCBI chr 1:115,849,168...115,850,767
Ensembl chr 1:115,849,105...115,850,767 		JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 increases expression ISO Buthionine Sulfoximine results in increased expression of NDUFA13 mRNA CTD PMID:15878706 NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726
Ensembl chr 7:19,526,565...19,535,726 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
affects expression		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Acrolein]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Chlorambucil]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to cumene hydroperoxide]; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione]; Buthionine Sulfoximine promotes the reaction [1,2-dihydroxynaphthalene analog results in increased activity of NFE2L2 protein]; Buthionine Sulfoximine promotes the reaction [arsenite results in increased expression of NFE2L2 protein]; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased phosphorylation of NFE2L2 protein]
Buthionine Sulfoximine results in increased expression of NFE2L2 protein
[Buthionine Sulfoximine co-treated with sulforaphane] affects the expression of and affects the localization of NFE2L2 protein; Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of and affects the localization of NFE2L2 protein]; Buthionine Sulfoximine inhibits the reaction [decamethrin results in increased expression of NFE2L2 mRNA]; Buthionine Sulfoximine promotes the reaction [Arsenic Trioxide results in increased expression of and affects the localization of NFE2L2 protein]
Buthionine Sulfoximine affects the expression of NFE2L2 protein
Buthionine Sulfoximine results in increased expression of NFE2L2 mRNA
[6-formylindolo(3,2-b)carbazole co-treated with Buthionine Sulfoximine] results in increased expression of NFE2L2 mRNA; Buthionine Sulfoximine affects the localization of and results in increased activity of NFE2L2 protein; Buthionine Sulfoximine affects the reaction [[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Acrolein]; Buthionine Sulfoximine affects the reaction [[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Chlorambucil]; Buthionine Sulfoximine inhibits the reaction [Dextromethorphan results in increased activity of NFE2L2 protein]; Buthionine Sulfoximine inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA]; Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Acrolein]]; Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to Chlorambucil]]; Buthionine Sulfoximine inhibits the reaction [NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to cumene hydroperoxide]]		 CTD PMID:17980396 PMID:18785192 PMID:19303893 PMID:19608619 PMID:20932822 More... NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]] CTD PMID:11970852 PMID:12433058 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression		 EXP
ISO		 Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]
NGF protein affects the reaction [Buthionine Sulfoximine results in increased expression of NFKBIA mRNA]		 CTD PMID:11970852 PMID:12433058 PMID:23472850 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ngf nerve growth factor multiple interactions
affects response to substance
increases expression		 ISO Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased expression of NGF mRNA]; NGF protein affects the reaction [Buthionine Sulfoximine results in increased expression of NFKBIA mRNA]; NGF protein affects the reaction [Buthionine Sulfoximine results in increased expression of TXN1 mRNA]; NGF protein affects the reaction [Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein]
NGF protein affects the susceptibility to Buthionine Sulfoximine		 CTD PMID:23472850 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO
EXP		 [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of NLRP3 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of NLRP3 mRNA		 CTD PMID:23986454 PMID:26177832 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 EXP
ISO		 [Carmustine co-treated with Buthionine Sulfoximine] inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Buthionine Sulfoximine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; Buthionine Sulfoximine promotes the reaction [Carmustine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]; Buthionine Sulfoximine promotes the reaction [Potassium Cyanide results in increased expression of NOS2 protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]
Buthionine Sulfoximine results in increased expression of NOS2 mRNA
[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA; Acetylcysteine inhibits the reaction [[ferric ammonium citrate co-treated with Buthionine Sulfoximine] results in increased expression of NOS2 mRNA]
Buthionine Sulfoximine promotes the reaction [Trioxsalen analog results in decreased expression of NOS2 mRNA]		 CTD PMID:7532384 PMID:9826428 PMID:16259964 PMID:16933320 PMID:23939143 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of NPC1 mRNA CTD PMID:15878706 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity
increases expression
multiple interactions		 EXP
ISO		 Buthionine Sulfoximine results in increased activity of NQO1 protein
Buthionine Sulfoximine results in increased expression of NQO1 mRNA
Buthionine Sulfoximine results in increased expression of NQO1 mRNA; Buthionine Sulfoximine results in increased expression of NQO1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA; Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of NQO1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]
[Buthionine Sulfoximine co-treated with chromium trioxide] results in increased activity of NQO1 protein; [Buthionine Sulfoximine co-treated with chromium trioxide] results in increased expression of NQO1 mRNA; [Tetrachlorodibenzodioxin co-treated with chromium trioxide co-treated with Buthionine Sulfoximine] results in increased expression of NQO1 mRNA; Buthionine Sulfoximine inhibits the reaction [chromium trioxide inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]]; Buthionine Sulfoximine inhibits the reaction [sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]]; Buthionine Sulfoximine inhibits the reaction [sodium arsenite results in increased activity of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [[Benzene co-treated with Toluene] results in increased activity of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Arsenic Trioxide promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]]; Buthionine Sulfoximine promotes the reaction [Benzene results in increased activity of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased activity of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Copper results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Copper results in increased expression of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Lead results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Lead results in increased expression of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [Mercury results in increased expression of NQO1 mRNA]; Buthionine Sulfoximine promotes the reaction [Mercury results in increased expression of NQO1 protein]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of NQO1 mRNA]
[Buthionine Sulfoximine co-treated with Endosulfan] results in increased expression of NQO1 mRNA; [Buthionine Sulfoximine co-treated with sulforaphane] results in increased expression of NQO1 protein; Buthionine Sulfoximine promotes the reaction [Methylcholanthrene results in increased activity of NQO1 protein]; Methylcholanthrene promotes the reaction [Buthionine Sulfoximine results in increased activity of NQO1 protein]		 CTD PMID:16274885 PMID:16906435 PMID:18752316 PMID:20079720 PMID:21971136 More... NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 increases expression ISO Buthionine Sulfoximine results in increased expression of NR2F2 mRNA CTD PMID:15878706 NCBI chr 1:124,008,282...124,022,521
Ensembl chr 1:124,009,181...124,022,031 		JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions ISO Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein]; Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein; NGF protein affects the reaction [Buthionine Sulfoximine results in increased phosphorylation of and results in increased activity of NTRK1 protein] CTD PMID:23472850 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator decreases expression ISO Buthionine Sulfoximine results in decreased expression of NUPR1 mRNA CTD PMID:15878706 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Odc1 ornithine decarboxylase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of ODC1 protein CTD PMID:9763232 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions
affects response to substance		 ISO Buthionine Sulfoximine affects the reaction [OGG1 protein affects the expression of SOD2 mRNA]
OGG1 protein affects the susceptibility to Buthionine Sulfoximine		 CTD PMID:32585298 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766 		JBrowse link
G Orm1 orosomucoid 1 increases expression EXP Buthionine Sulfoximine results in increased expression of ORM1 mRNA; Buthionine Sulfoximine results in increased expression of ORM1 protein CTD PMID:11841787 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of P4HA1 mRNA CTD PMID:15878706 NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate affects the cleavage of PARP1 protein]; Buthionine Sulfoximine promotes the reaction [wedelolactone results in increased cleavage of PARP1 protein] CTD PMID:20962031 PMID:22733624 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression
multiple interactions		 EXP Buthionine Sulfoximine results in increased expression of PCK1 mRNA
SB 203580 inhibits the reaction [Buthionine Sulfoximine results in increased expression of PCK1 mRNA]		 CTD PMID:16960379 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pcna proliferating cell nuclear antigen increases expression EXP
ISO		 Buthionine Sulfoximine results in increased expression of PCNA protein
Buthionine Sulfoximine results in increased expression of PCNA mRNA		 CTD PMID:9763232 PMID:15707499 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB mRNA]]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB protein]] CTD PMID:23392711 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 increases expression EXP Buthionine Sulfoximine results in increased expression of PDIA3 protein CTD PMID:23736079 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PDK1 protein] CTD PMID:17171638 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pfas phosphoribosylformylglycinamidine synthase increases expression EXP Buthionine Sulfoximine results in increased expression of PFAS protein CTD PMID:23736079 NCBI chr10:53,690,301...53,711,811
Ensembl chr10:53,691,626...53,708,420 		JBrowse link
G Phtf1 putative homeodomain transcription factor 1 increases expression ISO Buthionine Sulfoximine results in increased expression of PHTF1 mRNA CTD PMID:15878706 NCBI chr 2:191,470,849...191,537,399
Ensembl chr 2:191,473,130...191,512,078 		JBrowse link
G Plxna3 plexin A3 decreases expression ISO Buthionine Sulfoximine results in decreased expression of PLXNA3 mRNA CTD PMID:15878706 NCBI chr  X:152,115,699...152,131,608
Ensembl chr  X:152,115,819...152,131,603 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO
EXP		 PPARG mRNA promotes the reaction [Tamoxifen inhibits the reaction [Buthionine Sulfoximine results in increased expression of CD36 protein]]; S-ethyl glutathione inhibits the reaction [Buthionine Sulfoximine results in increased expression of PPARG mRNA]
Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of PPARG mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in increased expression of PPARG protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in increased expression of PPARG protein]		 CTD PMID:17602960 PMID:21520053 PMID:27358406 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppm1g protein phosphatase, Mg2+/Mn2+ dependent, 1G decreases expression ISO Buthionine Sulfoximine results in decreased expression of PPM1G mRNA CTD PMID:15878706 NCBI chr 6:25,153,556...25,173,763
Ensembl chr 6:25,153,556...25,173,761 		JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha increases expression ISO Buthionine Sulfoximine results in increased expression of PPP3CA mRNA CTD PMID:15878706 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974 		JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit decreases expression ISO Buthionine Sulfoximine results in decreased expression of PPP5C mRNA CTD PMID:15878706 NCBI chr 1:77,690,203...77,714,507
Ensembl chr 1:77,690,208...77,714,456 		JBrowse link
G Prdx1 peroxiredoxin 1 increases expression
affects expression		 ISO Buthionine Sulfoximine results in increased expression of PRDX1 mRNA
Buthionine Sulfoximine affects the expression of PRDX1 mRNA		 CTD PMID:9506838 PMID:15707499 NCBI chr 5:130,147,258...130,162,856
Ensembl chr 5:130,147,204...130,162,856 		JBrowse link
G Prim2 DNA primase subunit 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of PRIM2 mRNA CTD PMID:15878706 NCBI chr 9:35,692,376...35,904,521
Ensembl chr 9:35,692,376...35,903,030 		JBrowse link
G Prkca protein kinase C, alpha decreases activity EXP Buthionine Sulfoximine results in decreased activity of PRKCA protein CTD PMID:11118818 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcb protein kinase C, beta decreases activity EXP Buthionine Sulfoximine results in decreased activity of PRKCB protein CTD PMID:11118818 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO
EXP		 Buthionine Sulfoximine promotes the reaction [Curcumin results in increased phosphorylation of PRKCD protein]
Buthionine Sulfoximine results in increased expression of and results in increased activity of PRKCD protein; Cycloheximide inhibits the reaction [Buthionine Sulfoximine results in increased expression of PRKCD protein]		 CTD PMID:11118818 PMID:17171638 NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP Buthionine Sulfoximine results in increased expression of and results in increased activity of PRKCE protein; Cycloheximide inhibits the reaction [Buthionine Sulfoximine results in increased expression of PRKCE protein] CTD PMID:11118818 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Prpf19 pre-mRNA processing factor 19 increases expression EXP Buthionine Sulfoximine results in increased expression of PRPF19 protein CTD PMID:23736079 NCBI chr 1:207,541,582...207,552,664
Ensembl chr 1:207,541,595...207,552,662 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased degradation of and results in decreased expression of PTEN protein]; Buthionine Sulfoximine promotes the reaction [Cadmium results in increased degradation of and results in decreased expression of PTEN protein] CTD PMID:24449419 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of PTGS2 mRNA] CTD PMID:23376440 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2 protein tyrosine kinase 2 increases expression ISO Buthionine Sulfoximine results in increased expression of PTK2 mRNA CTD PMID:15878706 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 increases oxidation EXP Buthionine Sulfoximine results in increased oxidation of PTPN1 protein CTD PMID:20482862 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin increases expression ISO Buthionine Sulfoximine results in increased expression of PTTG1 mRNA CTD PMID:15878706 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837 		JBrowse link
G Rbbp6 RB binding protein 6, ubiquitin ligase decreases expression ISO Buthionine Sulfoximine results in decreased expression of RBBP6 mRNA CTD PMID:15878706 NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides affects the localization of REL protein] CTD PMID:11970852 PMID:12433058 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases expression		 ISO
EXP		 [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [carnosol results in increased glutathionylation of RELA protein]; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine promotes the reaction [arsenite results in increased phosphorylation of RELA protein]
Buthionine Sulfoximine results in increased expression of RELA protein
Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides results in increased activity of [NFKB1 protein binds to RELA protein]]
Buthionine Sulfoximine affects the reaction [Dextromethorphan affects the activity of RELA protein]; Buthionine Sulfoximine promotes the reaction [Sodium Selenite results in increased expression of RELA mRNA]
Buthionine Sulfoximine results in increased expression of RELA mRNA		 CTD PMID:11970852 PMID:12433058 PMID:18449455 PMID:20116392 PMID:20351055 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Lipopolysaccharides affects the localization of RELB protein] CTD PMID:11970852 PMID:12433058 NCBI chr 1:79,257,738...79,285,490
Ensembl chr 1:79,257,725...79,285,507 		JBrowse link
G Rorc RAR-related orphan receptor C increases expression EXP Buthionine Sulfoximine results in increased expression of RORC mRNA CTD PMID:26177832 NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907 		JBrowse link
G Rpl10a ribosomal protein L10A increases expression ISO Buthionine Sulfoximine results in increased expression of RPL10A mRNA CTD PMID:15878706 NCBI chr20:6,388,800...6,391,358
Ensembl chr20:6,385,823...6,391,357
Ensembl chr 9:6,385,823...6,391,357 		JBrowse link
G Rpl12 ribosomal protein L12 increases expression ISO Buthionine Sulfoximine results in increased expression of RPL12 mRNA CTD PMID:15878706 NCBI chr 3:16,264,269...16,266,645
Ensembl chr 3:16,264,251...16,266,642 		JBrowse link
G Rpl3 ribosomal protein L3 decreases expression ISO Buthionine Sulfoximine results in decreased expression of RPL3 mRNA CTD PMID:15878706 NCBI chr 7:111,622,255...111,627,640
Ensembl chr 7:111,621,610...111,636,468 		JBrowse link
G Rpl6 ribosomal protein L6 increases expression ISO Buthionine Sulfoximine results in increased expression of RPL6 mRNA CTD PMID:15707499 NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921 		JBrowse link
G Rpl8 ribosomal protein L8 increases expression ISO Buthionine Sulfoximine results in increased expression of RPL8 mRNA CTD PMID:15878706 NCBI chr 7:108,626,194...108,628,485
Ensembl chr 7:108,622,324...108,628,482
Ensembl chr 3:108,622,324...108,628,482 		JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression ISO Buthionine Sulfoximine results in increased expression of RPLP0 mRNA CTD PMID:15878706 NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632 		JBrowse link
G Rplp1 ribosomal protein lateral stalk subunit P1 increases expression ISO Buthionine Sulfoximine results in increased expression of RPLP1 mRNA CTD PMID:15878706 NCBI chr 8:62,394,008...62,395,341
Ensembl chr 8:62,393,177...62,395,339 		JBrowse link
G Rps12 ribosomal protein S12 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS12 mRNA CTD PMID:15878706 NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014 		JBrowse link
G Rps14 ribosomal protein S14 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS14 mRNA CTD PMID:15878706 NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166 		JBrowse link
G Rps15 ribosomal protein S15 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS15 mRNA CTD PMID:15878706 NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450
Ensembl chr 7:9,416,004...9,417,450 		JBrowse link
G Rps20 ribosomal protein S20 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS20 mRNA CTD PMID:15878706 NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475
Ensembl chr 5:16,819,304...16,820,475 		JBrowse link
G Rps26 ribosomal protein S26 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS26 mRNA CTD PMID:15878706 NCBI chr 7:1,057,332...1,058,882
Ensembl chr  X:107,822,178...107,822,525 		JBrowse link
G Rps6 ribosomal protein S6 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS6 mRNA CTD PMID:15878706 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps7 ribosomal protein S7 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS7 mRNA CTD PMID:15878706 NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145
Ensembl chr 5:45,223,980...45,271,145 		JBrowse link
G Rps8 ribosomal protein S8 increases expression ISO Buthionine Sulfoximine results in increased expression of RPS8 mRNA CTD PMID:15878706 NCBI chr 5:130,630,362...130,632,932
Ensembl chr 5:130,629,716...130,633,268 		JBrowse link
G S100a8 S100 calcium binding protein A8 multiple interactions ISO
EXP		 [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A8 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA; [Troglitazone co-treated with Buthionine Sulfoximine] results in increased expression of S100A8 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA]		 CTD PMID:23986454 PMID:26177832 PMID:28263783 PMID:30853469 PMID:31294483 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643 		JBrowse link
G S100a9 S100 calcium binding protein A9 multiple interactions ISO
EXP		 [Buthionine Sulfoximine co-treated with Lovastatin co-treated with Gemfibrozil] results in increased expression of S100A9 mRNA; [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA; [Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA; [Troglitazone co-treated with Buthionine Sulfoximine] results in increased expression of S100A9 mRNA; [zomepirac co-treated with Buthionine Sulfoximine co-treated with tri-o-cresyl phosphate] results in increased expression of S100A9 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA]		 CTD PMID:23986454 PMID:26177832 PMID:28263783 PMID:29154782 PMID:30853469 More... NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230 		JBrowse link
G Scarna15 small Cajal body-specific RNA 15 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in increased expression of MIR1839 mRNA CTD PMID:27421576 NCBI chr 1:135,484,620...135,484,683
Ensembl chr 1:135,484,559...135,484,685
Ensembl chr 1:135,484,559...135,484,685 		JBrowse link
G Sele selectin E multiple interactions ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA] CTD PMID:21971136 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Selenow selenoprotein W decreases expression
multiple interactions		 ISO Buthionine Sulfoximine results in decreased expression of SELENOW mRNA
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased expression of SELENOW mRNA		 CTD PMID:15823556 NCBI chr 1:76,599,441...76,604,514
Ensembl chr 1:76,598,779...76,604,724
Ensembl chr 1:76,598,779...76,604,724 		JBrowse link
G Serpina3n serpin family A member 3N decreases expression ISO Buthionine Sulfoximine results in decreased expression of SERPINA3N mRNA CTD PMID:15707499 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP Buthionine Sulfoximine results in increased expression of SERPINE1 mRNA CTD PMID:23939143 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sesn2 sestrin 2 increases expression ISO Buthionine Sulfoximine results in increased expression of SESN2 protein CTD PMID:31323261 NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260 		JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 decreases expression ISO Buthionine Sulfoximine results in decreased expression of SHANK3 mRNA CTD PMID:15878706 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374 		JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 decreases expression ISO Buthionine Sulfoximine results in decreased expression of SIAH2 mRNA CTD PMID:15878706 NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950 		JBrowse link
G Sin3a SIN3 transcription regulator family member A multiple interactions EXP Buthionine Sulfoximine affects the reaction [SIN3A protein binds to MYC promoter] CTD PMID:19289167 NCBI chr 8:57,481,539...57,536,195
Ensembl chr 8:57,481,573...57,536,192 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [SLC31A1 protein results in increased import of Copper]; Buthionine Sulfoximine inhibits the reaction [SLC31A1 protein results in increased import of Copper]; glutathione diethyl ester inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [SLC31A1 protein results in increased import of Copper]] CTD PMID:23426973 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased activity of SLC9A3 protein] CTD PMID:23876469 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417 		JBrowse link
G Snca synuclein alpha increases expression ISO Buthionine Sulfoximine results in increased expression of SNCA protein CTD PMID:15114628 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Snta1 syntrophin, alpha 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of SNTA1 mRNA CTD PMID:15878706 NCBI chr 3:142,876,285...142,906,737
Ensembl chr 3:142,876,296...142,906,709 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Buthionine Sulfoximine results in increased expression of SOD1 mRNA CTD PMID:15707499 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
increases response to substance		 ISO [Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA; Deferoxamine inhibits the reaction [[Buthionine Sulfoximine co-treated with SOD2 protein] results in increased expression of MMP1 mRNA]
Buthionine Sulfoximine affects the reaction [OGG1 protein affects the expression of SOD2 mRNA]
SOD2 protein results in increased susceptibility to Buthionine Sulfoximine		 CTD PMID:8877099 PMID:10464329 PMID:15130278 PMID:32585298 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sord sorbitol dehydrogenase multiple interactions ISO Buthionine Sulfoximine promotes the reaction [Diclofenac results in increased secretion of SORD protein] CTD PMID:12763371 NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133 		JBrowse link
G Sox4 SRY-box transcription factor 4 multiple interactions ISO [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of SOX4 mRNA; [Methimazole co-treated with Buthionine Sulfoximine] results in decreased expression of SOX4 protein CTD PMID:27421576 NCBI chr17:35,667,809...35,672,515
Ensembl chr17:35,667,537...35,673,665 		JBrowse link
G Sp1 Sp1 transcription factor increases activity
multiple interactions		 ISO Buthionine Sulfoximine results in increased activity of SP1 protein
mithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP1 protein]		 CTD PMID:11261509 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961 		JBrowse link
G Sp3 Sp3 transcription factor multiple interactions
increases activity		 ISO mithramycin A inhibits the reaction [Buthionine Sulfoximine results in increased activity of SP3 protein] CTD PMID:11261509 NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342 		JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO Buthionine Sulfoximine results in decreased expression of SPP1 mRNA CTD PMID:15707499 PMID:15878706 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP Buthionine Sulfoximine results in decreased expression of SREBF1 mRNA CTD PMID:20482862 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Buthionine Sulfoximine inhibits the reaction [Metformin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein]]; Buthionine Sulfoximine promotes the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein] CTD PMID:29499335 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Buthionine Sulfoximine results in increased expression of SRXN1 protein CTD PMID:27358234 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases activity
multiple interactions
increases phosphorylation
increases expression		 EXP
ISO		 Buthionine Sulfoximine results in increased activity of STAT3 protein
[Buthionine Sulfoximine results in increased phosphorylation of STAT3 protein] promotes the reaction [CREBBP protein results in increased acetylation of STAT3 protein modified form]; Buthionine Sulfoximine promotes the reaction [STAT3 protein modified form binds to MYC promoter]
[Troglitazone co-treated with Buthionine Sulfoximine] results in increased phosphorylation of STAT3 protein
Buthionine Sulfoximine results in increased expression of STAT3 mRNA		 CTD PMID:11841787 PMID:19289167 PMID:31294483 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Syn1 synapsin I increases expression ISO Buthionine Sulfoximine results in increased expression of SYN1 mRNA CTD PMID:15878706 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396 		JBrowse link
G Syp synaptophysin multiple interactions EXP (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate inhibits the reaction [[ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in decreased expression of SYP protein]; [ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in decreased expression of SYP protein CTD PMID:19850110 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tbca tubulin folding cofactor A increases expression ISO Buthionine Sulfoximine results in increased expression of TBCA mRNA CTD PMID:15878706 NCBI chr 2:26,011,714...26,065,909
Ensembl chr 2:26,011,795...26,065,907 		JBrowse link
G Tbx21 T-box transcription factor 21 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TBX21 mRNA CTD PMID:23986454 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tgfa transforming growth factor alpha multiple interactions ISO Buthionine Sulfoximine promotes the reaction [arsenite results in increased expression of and results in increased secretion of TGFA protein] CTD PMID:36343453 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR1 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR1 protein] CTD PMID:17602960 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR2 mRNA]; Buthionine Sulfoximine inhibits the reaction [Acetylcysteine results in decreased expression of TGFBR2 protein]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 mRNA]; Buthionine Sulfoximine inhibits the reaction [Curcumin results in decreased expression of TGFBR2 protein] CTD PMID:17602960 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Buthionine Sulfoximine results in decreased expression of THRSP mRNA CTD PMID:20482862 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075 		JBrowse link
G Tinf2 TERF1 interacting nuclear factor 2 increases expression ISO Buthionine Sulfoximine results in increased expression of TINF2 mRNA CTD PMID:15878706 NCBI chr15:29,170,663...29,178,015
Ensembl chr15:29,170,652...29,176,984 		JBrowse link
G Tle5 TLE family member 5, transcriptional modulator increases expression ISO Buthionine Sulfoximine results in increased expression of TLE5 mRNA CTD PMID:15878706 NCBI chr 7:8,143,357...8,150,295
Ensembl chr 7:8,143,357...8,150,113 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in increased expression of TLR2 mRNA CTD PMID:23986454 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO
EXP		 [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR4 mRNA
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein]		 CTD PMID:23986454 PMID:26177832 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr9 toll-like receptor 9 multiple interactions ISO [Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TLR9 mRNA CTD PMID:23986454 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tmsb10 thymosin, beta 10 increases expression ISO Buthionine Sulfoximine results in increased expression of TMSB10 mRNA CTD PMID:15707499 NCBI chr 4:105,009,959...105,011,095
Ensembl chr 4:105,009,212...105,011,028 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein]; [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of TNF protein]; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [carnosol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein affects the localization of RELA protein]]; Buthionine Sulfoximine inhibits the reaction [cinnamaldehyde inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]; SB 203580 inhibits the reaction [Buthionine Sulfoximine promotes the reaction [TNF protein results in increased expression of CCL5 protein]]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]
[pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of TNF mRNA; Buthionine Sulfoximine inhibits the reaction [manganese chloride promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TNF mRNA; [Carmustine co-treated with Buthionine Sulfoximine] inhibits the reaction [TNF protein results in increased expression of NOS2 protein]; Acetylcysteine inhibits the reaction [[Buthionine Sulfoximine co-treated with Lipopolysaccharides] results in increased secretion of TNF protein]; Acetylcysteine inhibits the reaction [Buthionine Sulfoximine results in increased secretion of TNF protein]; Buthionine Sulfoximine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]; Buthionine Sulfoximine promotes the reaction [Carmustine inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]]; Buthionine Sulfoximine promotes the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Nitrites inhibits the reaction [[TNF protein results in increased activity of NOS2 protein] which results in increased chemical synthesis of Buthionine Sulfoximine]		 CTD PMID:7532384 PMID:11167962 PMID:11970852 PMID:12433058 PMID:15601679 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Top2b DNA topoisomerase II beta decreases expression ISO Buthionine Sulfoximine results in decreased expression of TOP2B mRNA CTD PMID:15707499 NCBI chr15:9,051,340...9,111,721
Ensembl chr15:9,051,341...9,112,085 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO
EXP		 [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [Benzo(a)pyrene results in increased activity of TP53 protein]
[cyanoginosin LR co-treated with Buthionine Sulfoximine] results in increased expression of TP53 protein		 CTD PMID:12807757 PMID:25410294 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP Buthionine Sulfoximine results in increased expression of TPI1 protein CTD PMID:23736079 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541 		JBrowse link
G Trap1 TNF receptor-associated protein 1 increases expression EXP Buthionine Sulfoximine results in increased expression of TRAP1 protein CTD PMID:23736079 NCBI chr10:11,464,882...11,498,931
Ensembl chr10:11,464,821...11,498,981 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 multiple interactions ISO 4-amylcinnamoylanthranilic acid inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein]; [Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein; Glutathione inhibits the reaction [[Buthionine Sulfoximine co-treated with Adenosine Diphosphate Ribose] results in increased activity of TRPM2 protein] CTD PMID:33309544 NCBI chr20:10,703,568...10,753,189
Ensembl chr20:10,707,014...10,753,181 		JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 multiple interactions EXP [Gadolinium results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine; [Ruthenium Red results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine CTD PMID:20064552 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517 		JBrowse link
G Txn1 thioredoxin 1 increases expression
multiple interactions		 ISO Buthionine Sulfoximine results in increased expression of TXN1 mRNA
Buthionine Sulfoximine inhibits the reaction [arsenite results in increased expression of TXN protein]
NGF protein affects the reaction [Buthionine Sulfoximine results in increased expression of TXN1 mRNA]		 CTD PMID:23472850 PMID:36343453 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions
increases response to substance
increases expression		 ISO
EXP		 Buthionine Sulfoximine inhibits the reaction [sulforaphane results in increased expression of TXNRD1 mRNA]; Buthionine Sulfoximine promotes the reaction [arsenite results in increased activity of TXNRD1 protein]; Buthionine Sulfoximine promotes the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]
TXNRD1 gene mutant form results in increased susceptibility to Buthionine Sulfoximine
Buthionine Sulfoximine results in increased expression of TXNRD1 mRNA
[Carmustine co-treated with Buthionine Sulfoximine] results in decreased activity of TXNRD1 protein		 CTD PMID:12663510 PMID:16288907 PMID:19010381 PMID:24853413 PMID:36343453 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G U2af2 U2 small nuclear RNA auxiliary factor 2 increases expression EXP Buthionine Sulfoximine results in increased expression of U2AF2 protein CTD PMID:23736079 NCBI chr 1:68,760,911...68,779,730
Ensembl chr 1:68,760,924...68,778,492 		JBrowse link
G Ubc ubiquitin C increases expression ISO Buthionine Sulfoximine results in increased expression of UBC mRNA CTD PMID:15878706 NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]
[Troglitazone co-treated with Buthionine Sulfoximine] results in increased expression of VCAM1 mRNA		 CTD PMID:16271621 PMID:21971136 PMID:31294483 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of VEGFA mRNA] CTD PMID:11641398 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vps26c VPS26 endosomal protein sorting factor C decreases expression ISO Buthionine Sulfoximine results in decreased expression of VPS26C mRNA CTD PMID:15878706 NCBI chr11:33,813,467...33,841,883
Ensembl chr11:33,792,389...33,841,447 		JBrowse link
G Xirp1 xin actin-binding repeat containing 1 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of XIRP1 mRNA CTD PMID:29679711 NCBI chr 8:119,744,778...119,757,547
Ensembl chr 8:119,747,419...119,757,349 		JBrowse link
G Zfp422 zinc finger protein 422 decreases expression ISO Buthionine Sulfoximine results in decreased expression of ZFP422 mRNA CTD PMID:15878706 NCBI chr 4:149,885,805...149,893,287
Ensembl chr 4:149,885,600...149,893,257 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        biochemical role 19549
          ferroptosis inducer 15737
            S-butyl-DL-homocysteine (S,R)-sulfoximine 328
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    main group molecular entity 19811
                      s-block molecular entity 19647
                        hydrogen molecular entity 19628
                          hydrides 19139
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17865
                                        amino acid 16057
                                          alpha-amino acid 13932
                                            non-proteinogenic alpha-amino acid 3802
                                              homocysteines 421
                                                2-amino-4-(S-butylsulfonimidoyl)butanoic acid 328
                                                  D-buthionine-(S,R)-sulfoximine 328
                                                    S-butyl-DL-homocysteine (S,R)-sulfoximine 328
paths to the root