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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:kynurenine
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Accession:CHEBI:28683 term browser browse the term
Definition:A ketone that is alanine in which one of the methyl hydrogens is substituted by a 2-aminobenzoyl group.
Synonyms:related_synonym: 2-amino-4-(2-aminophenyl)-4-oxobutanoic acid;   Formula=C10H12N2O3;   InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15);   InChIKey=YGPSJZOEDVAXAB-UHFFFAOYSA-N;   SMILES=NC(CC(=O)c1ccccc1N)C(O)=O
 alt_id: CHEBI:24992;   CHEBI:6148
 xref: CAS:343-65-7;   KEGG:C01718
 xref_mesh: MESH:D007737
 xref: PMID:14651996;   PMID:16139256;   PMID:17386621;   PMID:19027117;   PMID:22770225;   Reaxys:2697333
 cyclic_relationship: is_conjugate_acid_of CHEBI:67008


show annotations for term's descendants           Sort by:
kynurenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases expression		 ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Kynurenine co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of AHR mRNA]; [indeno(1,2,3-cd)pyrene results in increased expression of AHR protein] which results in increased abundance of Kynurenine; [Kynurenine co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of AHR mRNA
Kynurenine results in increased expression of AHR mRNA		 CTD PMID:32781018 PMID:35687267 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G App amyloid beta precursor protein multiple interactions
increases abundance		 ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Kynurenine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Kynurenine]
PF-06840003 inhibits the reaction [APP protein mutant form results in increased abundance of Kynurenine]		 CTD PMID:39172838 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO Kynurenine inhibits the reaction [IDO2 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP1A1 mRNA]]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Kynurenine co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1A1 mRNA]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Kynurenine results in increased expression of CYP1A1 protein]; [Kynurenine co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1A1 mRNA
Kynurenine results in increased expression of CYP1A1 mRNA; Kynurenine results in increased expression of CYP1A1 protein		 CTD PMID:32289347 PMID:32781018 PMID:37979659 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
increases expression		 ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Kynurenine co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1B1 mRNA]; [Kynurenine co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased expression of CYP1B1 mRNA
Kynurenine results in increased expression of CYP1B1 mRNA		 CTD PMID:32781018 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 decreases abundance ISO IDO1 gene mutant form results in decreased abundance of Kynurenine CTD PMID:32871117 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730 		JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 increases chemical synthesis
multiple interactions		 ISO IDO2 protein results in increased chemical synthesis of Kynurenine
IDO2 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased abundance of Kynurenine]; Kynurenine inhibits the reaction [IDO2 gene mutant form inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP1A1 mRNA]]		 CTD PMID:32289347 NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324 		JBrowse link
G Ifng interferon gamma multiple interactions
increases chemical synthesis		 ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[IFNG protein co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased abundance of Kynurenine]; [IFNG protein co-treated with [Medroxyprogesterone Acetate co-treated with Cyclic AMP]] results in increased abundance of Kynurenine; salinomycin inhibits the reaction [IFNG protein results in increased chemical synthesis of Kynurenine] CTD PMID:32781018 PMID:32822738 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 multiple interactions
increases expression		 ISO 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Kynurenine promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]]; Kynurenine promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of IGFBP1 mRNA]
Kynurenine results in increased expression of IGFBP1 mRNA		 CTD PMID:32781018 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482 		JBrowse link
G Kmo kynurenine 3-monooxygenase multiple interactions EXP [KMO protein results in increased hydroxylation of Kynurenine] which results in increased chemical synthesis of 3-hydroxykynurenine CTD PMID:32243540 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881 		JBrowse link
G Kynu kynureninase increases expression ISO Kynurenine results in increased expression of KYNU mRNA CTD PMID:32781018 NCBI chr 3:27,778,646...27,929,470
Ensembl chr 3:27,778,772...27,929,488 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
increases abundance		 ISO [amyloid beta-protein (1-42) binds to MAPT protein] which results in increased abundance of Kynurenine; PF-06840003 inhibits the reaction [[amyloid beta-protein (1-42) binds to MAPT protein] which results in increased abundance of Kynurenine]
[amyloid beta-protein (1-42) binds to MAPT protein] which results in increased abundance of Kynurenine; PF-06840003 inhibits the reaction [[amyloid beta-protein (1-42) binds to MAPT protein] which results in increased abundance of Kynurenine]; PF-06840003 inhibits the reaction [MAPT protein mutant form results in increased abundance of Kynurenine]		 CTD PMID:39172838 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase increases expression
multiple interactions		 ISO Kynurenine results in increased expression of PRKN protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Kynurenine results in increased expression of PRKN protein]		 CTD PMID:37979659 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Prl prolactin increases expression
multiple interactions		 ISO Kynurenine results in increased expression of PRL mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Kynurenine promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]]; Kynurenine promotes the reaction [[Medroxyprogesterone Acetate co-treated with Cyclic AMP] results in increased expression of PRL mRNA]		 CTD PMID:32781018 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Psen1 presenilin 1 multiple interactions ISO [APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Kynurenine; PF-06840003 inhibits the reaction [[APP protein mutant form co-treated with PSEN1 protein mutant form] results in increased abundance of Kynurenine] CTD PMID:39172838 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase decreases abundance ISO TDO2 gene mutant form results in decreased abundance of Kynurenine CTD PMID:32871117 NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511 		JBrowse link
3-hydroxykynurenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kmo kynurenine 3-monooxygenase multiple interactions EXP [KMO protein results in increased hydroxylation of Kynurenine] which results in increased chemical synthesis of 3-hydroxykynurenine CTD PMID:32243540 NCBI chr13:87,557,080...87,589,334
Ensembl chr13:87,557,286...87,588,881 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      application 19730
        NMR chemical shift reference compound 18074
          ammonia 17895
            organic amino compound 17895
              aromatic amine 15503
                anilines 14438
                  substituted aniline 14069
                    kynurenine 15
                      D-kynurenine 0
                      L-kynurenine + 0
                      N-acetylkynurenine 0
                      N-formylkynurenine + 0
                      hydroxykynurenine + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    main group molecular entity 19855
                      s-block molecular entity 19666
                        hydrogen molecular entity 19668
                          hydrides 19176
                            inorganic hydride 18187
                              pnictogen hydride 18177
                                nitrogen hydride 18090
                                  azane 17896
                                    ammonia 17895
                                      organic amino compound 17895
                                        aromatic amine 15503
                                          anilines 14438
                                            substituted aniline 14069
                                              kynurenine 15
                                                D-kynurenine 0
                                                L-kynurenine + 0
                                                N-acetylkynurenine 0
                                                N-formylkynurenine + 0
                                                hydroxykynurenine + 1
paths to the root