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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:farnesol
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Accession:CHEBI:28600 term browser browse the term
Definition:A farnesane sesquiterpenoid that is dodeca-2,6,10-triene substituted by methyl groups at positions 3, 7 and 11 and a hydroxy group at position 1.
Synonyms:exact_synonym: 3,7,11-trimethyldodeca-2,6,10-trien-1-ol
 related_synonym: 3,7,11-trimethyl-2,6,10-dodecatrien-1-ol;   3,7,11-trimethyl-2,6,10-dodecatrienol;   Formula=C15H26O;   InChI=1S/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3;   InChIKey=CRDAMVZIKSXKFV-UHFFFAOYSA-N;   SMILES=[H]C(CO)=C(C)CCC([H])=C(C)CCC=C(C)C;   farnesyl alcohol
 alt_id: CHEBI:24013;   CHEBI:24014;   CHEBI:4978
 xref: Beilstein:1763926;   CAS:4602-84-0;   DrugBank:DB02509;   HMDB:HMDB0004305;   KEGG:C01493;   KNApSAcK:C00003132;   LINCS:LSM-5398
 xref_mesh: MESH:D005204
 xref: PMID:17640272;   PMID:19402910;   PMID:23902158;   PMID:24987733;   Reaxys:1763926


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farnesol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa1a acetyl-CoA acyltransferase 1A multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACAA1 mRNA CTD PMID:30611723 NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624 		JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 multiple interactions
increases expression		 ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACAA2 mRNA
Farnesol analog results in increased expression of ACAA2 mRNA		 CTD PMID:30611723 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249 		JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACADM mRNA CTD PMID:30611723 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Acads acyl-CoA dehydrogenase short chain multiple interactions
increases expression		 ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACADS mRNA
Farnesol analog results in increased expression of ACADS mRNA		 CTD PMID:30611723 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898 		JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 increases expression ISO Farnesol analog results in increased expression of ACAT1 mRNA CTD PMID:30611723 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855 		JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression ISO Farnesol analog results in increased expression of ACAT2 mRNA CTD PMID:30611723 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821 		JBrowse link
G Acot1 acyl-CoA thioesterase 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOT1 mRNA CTD PMID:30611723 NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163 		JBrowse link
G Acot12 acyl-CoA thioesterase 12 increases expression
multiple interactions		 ISO Farnesol analog results in increased expression of ACOT12 mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOT12 mRNA		 CTD PMID:30611723 NCBI chr 2:22,986,867...23,027,538
Ensembl chr 2:22,986,626...23,027,536 		JBrowse link
G Acot6 acyl-CoA thioesterase 6 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of ACOT6 mRNA CTD PMID:30611723 NCBI chr 6:103,732,372...103,741,446
Ensembl chr 6:103,732,372...103,741,446 		JBrowse link
G Acox1 acyl-CoA oxidase 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACOX1 mRNA CTD PMID:30611723 NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232 		JBrowse link
G Acox2 acyl-CoA oxidase 2 decreases expression
increases expression		 ISO Farnesol analog results in decreased expression of ACOX2 mRNA
Farnesol analog results in increased expression of ACOX2 mRNA		 CTD PMID:30611723 NCBI chr15:16,660,584...16,692,160
Ensembl chr15:16,660,272...16,692,160 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACSL4 mRNA CTD PMID:30611723 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ACSL5 mRNA CTD PMID:30611723 NCBI chr 1:254,289,513...254,336,608
Ensembl chr 1:254,292,521...254,336,607 		JBrowse link
G Agpat1 1-acylglycerol-3-phosphate O-acyltransferase 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of AGPAT1 mRNA CTD PMID:30611723 NCBI chr20:4,135,955...4,144,880
Ensembl chr20:4,135,957...4,145,278 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases chemical synthesis ISO AKR1B10 protein results in increased chemical synthesis of Farnesol CTD PMID:21187079 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO Farnesol results in increased expression of AKR1C1 mRNA CTD PMID:30806763 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 increases chemical synthesis
multiple interactions		 ISO AKR1C3 protein results in increased chemical synthesis of Farnesol
[Flurbiprofen results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol; [tolfenamic acid results in decreased activity of AKR1C3 protein] which results in increased metabolism of Farnesol		 CTD PMID:21187079 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Apoa5 apolipoprotein A5 multiple interactions
increases expression		 ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of APOA5 mRNA
Farnesol analog results in increased expression of APOA5 mRNA		 CTD PMID:30611723 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816 		JBrowse link
G Apoc4 apolipoprotein C4 decreases expression ISO Farnesol analog results in decreased expression of APOC4 mRNA CTD PMID:30611723 NCBI chr 1:79,335,745...79,339,942
Ensembl chr 1:79,335,745...79,339,981 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Farnesol results in increased expression of ATF3 mRNA CTD PMID:27965148 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Farnesol results in increased expression of BAK1 protein CTD PMID:12530055 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Casp3 caspase 3 increases activity
decreases activity		 ISO
EXP		 Farnesol results in increased activity of CASP3 protein
Farnesol results in decreased activity of CASP3 protein		 CTD PMID:10733934 PMID:21453689 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase increases expression
multiple interactions		 EXP
ISO		 Farnesol results in increased expression of CAT protein
Farnesol inhibits the reaction [Tobacco Smoke Pollution results in decreased activity of CAT protein]
Farnesol inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]		 CTD PMID:18793622 PMID:21453689 PMID:37458150 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases secretion ISO Farnesol results in increased secretion of CCL4 protein CTD PMID:30806763 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Farnesol results in decreased expression of CCNA2 protein CTD PMID:17138864 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Farnesol results in decreased expression of CCNB1 protein CTD PMID:17138864 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions		 ISO Farnesol results in decreased expression of CDK2 protein
Farnesol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; Farnesol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]		 CTD PMID:17138864 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases response to substance
increases expression		 ISO Farnesol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]
CDKN1A protein results in increased susceptibility to Farnesol
Farnesol results in increased expression of CDKN1A protein		 CTD PMID:17138864 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases response to substance
multiple interactions
increases expression		 ISO CDKN1B protein results in increased susceptibility to Farnesol
Farnesol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
Farnesol results in increased expression of CDKN1B protein		 CTD PMID:17138864 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cox10 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 decreases expression ISO Farnesol analog results in decreased expression of COX10 mRNA CTD PMID:30611723 NCBI chr10:48,630,993...48,742,805
Ensembl chr10:48,630,676...48,746,667 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of CPT1A mRNA CTD PMID:30611723 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP19A1 protein CTD PMID:15840382 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
increases expression		 EXP
ISO		 Farnesol results in increased activity of CYP1A1 protein
Farnesol results in increased expression of CYP1A1 mRNA		 CTD PMID:15840382 PMID:30806763 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
multiple interactions		 EXP
ISO		 Farnesol results in increased activity of CYP1A2 protein
Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP1A2 mRNA]		 CTD PMID:15840382 PMID:30611723 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP2A1 protein CTD PMID:15840382 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887 		JBrowse link
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 increases activity EXP Farnesol results in increased activity of CYP2A2 protein CTD PMID:15840382 NCBI chr 1:82,263,833...82,289,487
Ensembl chr 1:82,263,833...82,289,487 		JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases activity EXP Farnesol results in increased activity of CYP2A3 protein CTD PMID:15840382 NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP2B1 protein CTD PMID:15840382 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases activity EXP Farnesol results in increased activity of CYP2B2 protein CTD PMID:15840382 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases expression		 ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of CYP2B6 mRNA; Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP2B6 mRNA]
Farnesol analog results in increased expression of CYP2B6 mRNA; Farnesol results in increased expression of CYP2B6 mRNA		 CTD PMID:30611723 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases activity EXP Farnesol results in increased activity of CYP2C11 protein CTD PMID:15840382 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 increases activity EXP Farnesol results in increased activity of CYP2C12 protein CTD PMID:15840382 NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases activity
decreases expression
multiple interactions		 EXP
ISO		 Farnesol results in increased activity of CYP2E1 protein
Farnesol analog results in decreased expression of CYP2E1 mRNA; Farnesol results in decreased expression of CYP2E1 mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of CYP2E1 mRNA; Farnesol analog inhibits the reaction [Oleic Acid results in increased expression of CYP2E1 mRNA]		 CTD PMID:15840382 PMID:30611723 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases activity
multiple interactions
increases expression		 EXP
ISO		 Farnesol results in increased activity of CYP3A2 protein
Farnesol analog inhibits the reaction [Oleic Acid results in decreased expression of CYP3A4 mRNA]
Farnesol results in increased expression of CYP3A4 mRNA		 CTD PMID:15840382 PMID:30611723 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP3A23-3A1 protein CTD PMID:15840382 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases activity EXP Farnesol results in increased activity of CYP4A1 protein CTD PMID:15840382 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464 		JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 increases activity EXP Farnesol results in increased activity of CYP4A2 protein CTD PMID:15840382 NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165 		JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 increases activity EXP Farnesol results in increased activity of CYP4A3 protein CTD PMID:15840382 NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463 		JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of DECR1 mRNA CTD PMID:30611723 NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 decreases expression ISO Farnesol analog results in decreased expression of DGAT1 mRNA CTD PMID:30611723 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299 		JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of DGAT2 mRNA CTD PMID:30611723 NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Farnesol results in increased expression of DNAJB4 mRNA CTD PMID:27965148 NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression ISO Farnesol analog results in increased expression of ECH1 mRNA CTD PMID:30611723 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO Farnesol analog inhibits the reaction [EGF protein results in increased activity of RHOA protein]; Farnesol analog results in decreased susceptibility to [INS protein co-treated with EGF protein] CTD PMID:24587105 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of ELOVL6 mRNA CTD PMID:30611723 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186 		JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Farnesol analog results in increased expression of FABP1 mRNA CTD PMID:30611723 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Fabp4 fatty acid binding protein 4 increases expression ISO Farnesol results in increased expression of FABP4 mRNA CTD PMID:30806763 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of FASN mRNA CTD PMID:30611723 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression ISO Farnesol analog results in increased expression of FDFT1 mRNA CTD PMID:30611723 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287 		JBrowse link
G Fnta farnesyltransferase, CAAX box, subunit alpha multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of FNTA mRNA CTD PMID:30611723 NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460 		JBrowse link
G Fntb farnesyltransferase, CAAX box, subunit beta decreases expression ISO Farnesol analog results in decreased expression of FNTB mRNA CTD PMID:30611723 NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586 		JBrowse link
G Gpat4 glycerol-3-phosphate acyltransferase 4 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of GPAT4 mRNA CTD PMID:30611723 NCBI chr16:68,819,031...68,852,903
Ensembl chr16:68,819,079...68,852,901 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Farnesol inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:37458150 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gsr glutathione-disulfide reductase increases activity
increases expression
multiple interactions		 EXP
ISO		 Farnesol results in increased activity of GSR protein
Farnesol results in increased expression of GSR protein
Farnesol inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]		 CTD PMID:15840382 PMID:21453689 PMID:37458150 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression
multiple interactions		 ISO Farnesol analog results in increased expression of HADHA mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of HADHA mRNA		 CTD PMID:30611723 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869 		JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression
multiple interactions		 ISO Farnesol analog results in increased expression of HADHB mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of HADHB mRNA		 CTD PMID:30611723 NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases activity
increases expression		 ISO
EXP		 [Farnesol analog co-treated with Oleic Acid] results in increased expression of HMGCR mRNA
Farnesol results in decreased activity of HMGCR protein
Farnesol results in increased expression of HMGCR protein		 CTD PMID:12477733 PMID:16332721 PMID:30611723 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Farnesol results in increased expression of HMOX1 mRNA CTD PMID:30806763 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO Farnesol inhibits the reaction [Simvastatin results in decreased farnesylation of and affects the localization of HRAS protein] CTD PMID:12477733 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression ISO Farnesol results in increased expression of ICAM1 mRNA CTD PMID:30806763 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Farnesol inhibits the reaction [Acetaminophen results in increased expression of IKBKB mRNA] CTD PMID:37458150 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il16 interleukin 16 increases secretion ISO Farnesol results in increased secretion of IL16 protein CTD PMID:30806763 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Farnesol results in increased expression of IL1A mRNA CTD PMID:30806763 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Farnesol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]
Farnesol inhibits the reaction [[Alendronate co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; Farnesol inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]		 CTD PMID:20304105 PMID:37458150 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1r2 interleukin 1 receptor type 2 increases expression ISO Farnesol results in increased expression of IL1R2 mRNA CTD PMID:30806763 NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Farnesol inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA] CTD PMID:37458150 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO Farnesol analog results in decreased susceptibility to [INS protein co-treated with EGF protein] CTD PMID:24587105 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Lipc lipase C, hepatic type increases expression ISO Farnesol analog results in increased expression of LIPC mRNA CTD PMID:30611723 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Lpin1 lipin 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of LPIN1 mRNA CTD PMID:30611723 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097 		JBrowse link
G Lpin3 lipin 3 decreases expression ISO Farnesol analog results in decreased expression of LPIN3 mRNA CTD PMID:30611723 NCBI chr 3:149,533,719...149,558,494
Ensembl chr 3:149,534,051...149,558,327 		JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of MLXIPL mRNA CTD PMID:30611723 NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112 		JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO Farnesol results in increased expression of MMP3 mRNA CTD PMID:30806763 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mvk mevalonate kinase decreases activity
multiple interactions		 ISO Farnesol results in decreased activity of MVK protein
Farnesol inhibits the reaction [[MVK gene mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL1B protein]; Farnesol inhibits the reaction [MVK gene mutant form results in increased susceptibility to Lipopolysaccharides]; Farnesol inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; Farnesol inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]		 CTD PMID:9392419 PMID:20304105 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Myl9 myosin light chain 9 multiple interactions ISO Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MYL9 protein] CTD PMID:24587105 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity EXP Farnesol results in increased activity of NQO1 protein CTD PMID:15840382 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression
multiple interactions		 ISO Farnesol analog results in decreased expression of NR0B2 mRNA
[Farnesol analog co-treated with Oleic Acid] results in decreased expression of NR0B2 mRNA		 CTD PMID:30611723 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases expression		 ISO Farnesol binds to and results in increased activity of NR1H4 protein
Farnesol analog results in decreased expression of NR1H4 mRNA		 CTD PMID:15491415 PMID:30611723 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
decreases expression		 ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of PCK1 mRNA
Farnesol analog results in decreased expression of PCK1 mRNA		 CTD PMID:30611723 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pdss1 decaprenyl diphosphate synthase subunit 1 increases expression ISO Farnesol analog results in increased expression of PDSS1 mRNA CTD PMID:30611723 NCBI chr17:85,059,953...85,098,739
Ensembl chr17:85,060,106...85,098,730 		JBrowse link
G Plin2 perilipin 2 increases expression
multiple interactions		 ISO Farnesol analog results in increased expression of PLIN2 mRNA
[Farnesol analog co-treated with Oleic Acid] results in increased expression of PLIN2 mRNA		 CTD PMID:30611723 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of PPARA mRNA; Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 PMID:30611723 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of PPARG mRNA
Farnesol analog results in increased expression of PPARG mRNA		 CTD PMID:30611723 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions EXP Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]] CTD PMID:22343369 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Rabggta Rab geranylgeranyltransferase subunit alpha multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of RABGGTA mRNA CTD PMID:30611723 NCBI chr15:29,206,328...29,213,398
Ensembl chr15:29,206,157...29,213,348 		JBrowse link
G Rabggtb Rab geranylgeranyltransferase subunit beta multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of RABGGTB mRNA CTD PMID:30611723 NCBI chr 2:242,844,758...242,850,951
Ensembl chr 2:242,844,762...242,851,050 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Farnasol inhibits the reaction [Ropivacaine decreases activity of RAC1 protein in esophageal carcinoma cells] RGD PMID:29777701 RGD:155230817 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP
ISO		 Farnesol inhibits the reaction [Lovastatin affects the localization of RHOA protein]
Farnesol analog inhibits the reaction [EGF protein results in increased activity of RHOA protein]; Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOA protein]		 CTD PMID:9398081 PMID:24587105 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rhoc ras homolog family member C multiple interactions ISO Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOC protein] CTD PMID:24587105 NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO Farnesol inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] CTD PMID:11779144 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in decreased expression of SCD mRNA CTD PMID:30611723 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Serpinb3 serpin family B member 3 increases expression ISO Farnesol results in increased expression of SERPINB3 mRNA CTD PMID:30806763 NCBI chr13:23,274,120...23,280,660
Ensembl chr13:23,274,484...23,313,682 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of SLC25A20 mRNA CTD PMID:30611723 NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512 		JBrowse link
G Slc27a1 solute carrier family 27 member 1 multiple interactions ISO [Farnesol analog co-treated with Oleic Acid] results in increased expression of SLC27A1 mRNA CTD PMID:30611723 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063 		JBrowse link
G Slc27a2 solute carrier family 27 member 2 increases expression ISO Farnesol analog results in increased expression of SLC27A2 mRNA CTD PMID:30611723 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression ISO Farnesol results in increased expression of SLC7A11 mRNA CTD PMID:30806763 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 EXP
ISO		 Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]]
Farnesol results in increased expression of TNF mRNA
Farnesol inhibits the reaction [Acetaminophen results in increased expression of TNF protein]		 CTD PMID:22343369 PMID:30806763 PMID:37458150 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of Farnesol CTD PMID:15320866 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      biological role 19852
        antimicrobial agent 18266
          farnesol 112
            (2-cis,6-cis)-farnesol 0
            (2-cis,6-trans)-farnesol 0
            (2-trans,6-cis)-farnesol 0
            (2-trans,6-trans)-farnesol + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            organic hydride 18711
                              organic fundamental parent 18711
                                hydrocarbon 18454
                                  terpene 14053
                                    terpenoid 13751
                                      sesquiterpenoid 3287
                                        farnesane sesquiterpenoid 140
                                          farnesol 112
                                            (2-cis,6-cis)-farnesol 0
                                            (2-cis,6-trans)-farnesol 0
                                            (2-trans,6-cis)-farnesol 0
                                            (2-trans,6-trans)-farnesol + 0
paths to the root