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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(20S)-20-hydroxypregn-4-en-3-one
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Accession:CHEBI:28453 term browser browse the term
Definition:A 20-hydroxypregn-4-en-3-one that has formula C21H32O2.
Synonyms:related_synonym: (20S)-hydroxypregn-4-en-3-one;   (S)-20-Hydroxypregn-4-en-3-one;   20alpha-Hydroxy-4-pregnen-3-one;   20alpha-Hydroxypregn-4-en-3-one;   20alpha-Hydroxyprogesterone;   20alpha-dihydroprogesterone;   Formula=C21H32O2;   InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16-,17+,18-,19-,20-,21+/m0/s1;   InChIKey=RWBRUCCWZPSBFC-RXRZZTMXSA-N;   SMILES=[H][C@@]1(CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)O;   dihydroprogesterone
 alt_id: CHEBI:1295;   CHEBI:19800;   CHEBI:387
 xref: Beilstein:2220567;   Beilstein:5754299;   CAS:145-14-2;   KEGG:C04042
 xref_mesh: MESH:D004092


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(20S)-20-hydroxypregn-4-en-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 increases chemical synthesis ISO AKR1C2 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone CTD PMID:11158055 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764 		JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
increases chemical synthesis		 ISO
EXP		 [AKR1C3 protein results in increased metabolism of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone; [AKR1C3 protein results in increased reduction of Progesterone] which results in increased chemical synthesis of 20-alpha-Dihydroprogesterone
AKR1C3 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone
AKR1C18 protein results in increased chemical synthesis of 20-alpha-Dihydroprogesterone		 CTD PMID:8172618 PMID:19010312 PMID:20036328 PMID:25463305 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873 		JBrowse link
G Mal mal, T-cell differentiation protein multiple interactions EXP 20-alpha-Dihydroprogesterone inhibits the reaction [docetaxel results in decreased expression of MAL mRNA] CTD PMID:19335538 NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136 		JBrowse link
G Mbp myelin basic protein multiple interactions EXP 20-alpha-Dihydroprogesterone inhibits the reaction [docetaxel results in decreased expression of MBP mRNA]; 20-alpha-Dihydroprogesterone inhibits the reaction [Streptozocin results in decreased expression of MBP mRNA] CTD PMID:19335538 PMID:20349157 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mpz myelin protein zero increases expression
multiple interactions		 EXP 20-alpha-Dihydroprogesterone results in increased expression of MPZ mRNA
20-alpha-Dihydroprogesterone inhibits the reaction [Docetaxel results in decreased expression of MPZ mRNA]; 20-alpha-Dihydroprogesterone inhibits the reaction [Streptozocin results in decreased expression of MPZ mRNA]		 CTD PMID:16787508 PMID:17187935 PMID:19335538 NCBI chr13:83,570,811...83,576,680
Ensembl chr13:83,570,811...83,576,679 		JBrowse link
G Pmp22 peripheral myelin protein 22 multiple interactions EXP 20-alpha-Dihydroprogesterone inhibits the reaction [docetaxel results in decreased expression of PMP22 mRNA] CTD PMID:19335538 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion		 ISO Cadmium Chloride inhibits the reaction [POMC protein results in increased secretion of 20-alpha-Dihydroprogesterone] CTD PMID:8299002 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    chemical entity 19915
      group 19869
        organic group 19015
          3-oxo-Delta(4)-steroid group 9169
            3-oxo-Delta(4) steroid 9169
              20-hydroxypregn-4-en-3-one 10
                (20S)-20-hydroxypregn-4-en-3-one 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    p-block element atom 19855
                      carbon group element atom 19774
                        carbon atom 19790
                          organic molecular entity 19790
                            heteroorganic entity 19549
                              organochalcogen compound 19309
                                organooxygen compound 19204
                                  carbonyl compound 18945
                                    ketone 17276
                                      oxo steroid 10541
                                        3-oxo steroid 9930
                                          3-oxo-Delta(4) steroid 9169
                                            20-hydroxypregn-4-en-3-one 10
                                              (20S)-20-hydroxypregn-4-en-3-one 7
paths to the root