CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: digitogenin
Accession: CHEBI:28431
browse the term
Definition: A 15beta-hydroxy steroid that has formula C27H44O5.
Synonyms: exact_synonym: (25R)-5alpha-spirostan-2alpha,3beta,15beta-triol
related_synonym: Formula=C27H44O5; InChI=1S/C27H44O5/c1-14-7-10-27(31-13-14)15(2)21-24(32-27)23(30)22-17-6-5-16-11-19(28)20(29)12-26(16,4)18(17)8-9-25(21,22)3/h14-24,28-30H,5-13H2,1-4H3/t14-,15+,16+,17-,18+,19-,20-,21+,22-,23+,24-,25-,26+,27-/m1/s1; InChIKey=COVOPPXLDJVUSC-JPYPKGSXSA-N; SMILES=[H][C@@]12CC[C@]3([H])[C@]([H])(CC[C@@]4(C)[C@@]3([H])[C@H](O)[C@]3([H])O[C@]5(CC[C@@H](C)CO5)[C@@H](C)[C@]43[H])[C@@]1(C)C[C@@H](O)[C@H](O)C2; digitonin aglycon
alt_id: CHEBI:23726; CHEBI:4547
xref: Beilstein:94573; CAS:511-34-2; Chemspider:390462; KEGG:C08896; KNApSAcK:C00003573; LIPID_MAPS_instance:LMST01080004; PMID:17135046; PMID:5545780; PMID:6097588
G
Ccnb1
cyclin B1
increases expression
ISO
Digitonin results in increased expression of CCNB1 protein
CTD
PMID:36030841
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
G
Ccnd1
cyclin D1
increases expression
ISO
Digitonin results in increased expression of CCND1 protein
CTD
PMID:36030841
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
G
Cdh5
cadherin 5
multiple interactions
ISO
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]
CTD
PMID:31404653
NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases expression
ISO
Digitonin results in decreased expression of CDKN1A protein
CTD
PMID:36030841
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
decreases expression
ISO
Digitonin results in decreased expression of CDKN1B protein
CTD
PMID:36030841
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression
ISO
Digitonin results in increased expression of CYP2B10 protein
CTD
PMID:36030841
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Etv2
ETS variant transcription factor 2
multiple interactions
ISO
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein]
CTD
PMID:31404653
NCBI chr 1:85,890,562...85,894,025
Ensembl chr 1:85,890,559...85,893,431
G
Gata2
GATA binding protein 2
multiple interactions
ISO
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in decreased expression of CDH5 protein]; Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein]
CTD
PMID:31404653
NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
G
Hexb
hexosaminidase subunit beta
multiple interactions increases activity
ISO
1,2-dioleoyl-sn-glycero-3-phosphoglycerol inhibits the reaction [Digitonin results in increased activity of HEXB protein]
CTD
PMID:36860548
NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
G
Hif1a
hypoxia inducible factor 1 subunit alpha
decreases expression
ISO
Digitonin results in decreased expression of HIF1A protein
CTD
PMID:34717917
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
G
Nek2
NIMA-related kinase 2
increases expression
ISO
Digitonin results in increased expression of NEK2 protein
CTD
PMID:36030841
NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051
G
Rbl2
RB transcriptional corepressor like 2
decreases expression
ISO
Digitonin results in decreased expression of RBL2 protein
CTD
PMID:36030841
NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Digitonin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Slco1a4
solute carrier organic anion transporter family, member 1a4
increases expression
ISO
Digitonin results in increased expression of SLCO1A4 protein
CTD
PMID:36030841
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
G
Spn
sialophorin
multiple interactions
ISO
Digitonin inhibits the reaction [[ETV2 protein co-treated with GATA2 protein] results in increased expression of SPN protein]
CTD
PMID:31404653
NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all