CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: alpha-carotene
Accession: CHEBI:28425
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Definition: A cyclic carotene with a beta- and an epsilon-ring at opposite ends respectively.
Synonyms: related_synonym: Formula=C40H56; InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-23,25-28,37H,15-16,24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+; InChIKey=ANVAOWXLWRTKGA-JLTXGRSLSA-N; SMILES=CC(\\C=C\\C=C(C)\\C=C\\C1C(C)=CCCC1(C)C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C; all-trans-alpha-carotene; beta,epsilon-Carotene
alt_id: CHEBI:10215; CHEBI:22447
xref: Beilstein:2067408; Beilstein:3227599; CAS:432-70-2; HMDB:HMDB0003993; KEGG:C05433; KNApSAcK:C00003765; LIPID_MAPS_instance:LMPR01070258
xref_mesh: MESH:C041635
xref: PMID:23620017; PMID:24169341; PMID:9408998; Reaxys:2682045
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Mgmt
O-6-methylguanine-DNA methyltransferase
affects response to substance
ISO
MGMT gene SNP affects the susceptibility to alpha-carotene
CTD
PMID:16014702
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Als2
alsin Rho guanine nucleotide exchange factor ALS2
multiple interactions decreases expression
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of ALS2 mRNA; [Cisplatin co-treated with Lutein] results in increased expression of ALS2 mRNA Lutein results in decreased expression of ALS2 mRNA
CTD
PMID:24865317
NCBI chr 9:60,613,182...60,686,394
Ensembl chr 9:60,613,167...60,670,737
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Apc
APC regulator of WNT signaling pathway
multiple interactions
ISO
[Cisplatin co-treated with Lutein] results in increased expression of APC mRNA
CTD
PMID:24865317
NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
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Aqr
aquarius intron-binding spliceosomal factor
decreases expression multiple interactions
ISO
Lutein results in decreased expression of AQR mRNA [Cisplatin co-treated with Lutein] results in decreased expression of AQR mRNA
CTD
PMID:24865317
NCBI chr 3:100,874,987...100,945,026
Ensembl chr 3:100,874,987...100,945,044
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Atr
ATR serine/threonine kinase
multiple interactions decreases expression
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of ATR mRNA Lutein results in decreased expression of ATR mRNA
CTD
PMID:24865317
NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
Lutein results in increased expression of BAX protein
CTD
PMID:17455471
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
Lutein results in decreased expression of BCL2 protein
CTD
PMID:17455471
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
increases expression
ISO
Lutein results in increased expression of BCL2L1 protein
CTD
PMID:10750663
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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Bco2
beta-carotene oxygenase 2
increases metabolic processing multiple interactions affects metabolic processing
ISO
BCO2 protein results in increased metabolism of Lutein [BCO2 protein affects the metabolism of Lutein] which results in increased abundance of 3'-dehydrolutein; [BCO2 protein results in increased metabolism of Lutein] which results in increased chemical synthesis of apocarotenal metabolite
CTD
PMID:21106934
NCBI chr 8:50,882,174...50,907,676
Ensembl chr 8:50,882,181...50,915,467
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Cat
catalase
multiple interactions
ISO
Lutein inhibits the reaction [deoxynivalenol results in increased expression of CAT protein]
CTD
PMID:20347963
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccnd1
cyclin D1
decreases expression
ISO
Lutein results in decreased expression of CCND1 protein
CTD
PMID:17718427
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccs
copper chaperone for superoxide dismutase
increases expression
ISO
Lutein results in increased expression of CCS mRNA
CTD
PMID:24865317
NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915
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Cfd
complement factor D
decreases expression decreases secretion
ISO
Lutein results in decreased expression of CFD mRNA Lutein results in decreased secretion of CFD protein
CTD
PMID:26504594
NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
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Ckb
creatine kinase B
multiple interactions
EXP
Lutein inhibits the reaction [Isoproterenol results in increased activity of CKB protein]
CTD
PMID:34435724
NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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Ctsb
cathepsin B
increases expression multiple interactions
ISO
Lutein results in increased expression of CTSB mRNA Cisplatin inhibits the reaction [Lutein results in increased expression of CTSB mRNA]
CTD
PMID:24865317
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Cyba
cytochrome b-245 alpha chain
multiple interactions decreases expression
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of CYBA mRNA Lutein results in decreased expression of CYBA mRNA
CTD
PMID:24865317
NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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Des
desmin
multiple interactions
EXP
Lutein inhibits the reaction [Isoproterenol results in decreased expression of DES protein]
CTD
PMID:34435724
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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Ercc2
ERCC excision repair 2, TFIIH core complex helicase subunit
decreases expression multiple interactions
ISO
Lutein results in decreased expression of ERCC2 mRNA [Cisplatin co-treated with Lutein] results in decreased expression of ERCC2 mRNA
CTD
PMID:24865317
NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102
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Ercc6
ERCC excision repair 6, chromatin remodeling factor
decreases expression
ISO
Lutein results in decreased expression of ERCC6 mRNA
CTD
PMID:24865317
NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
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Fmo2
flavin containing dimethylaniline monoxygenase 2
decreases expression
ISO
Lutein results in decreased expression of FMO2 mRNA
CTD
PMID:24865317
NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
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Gab1
GRB2-associated binding protein 1
decreases expression multiple interactions
ISO
Lutein results in decreased expression of GAB1 mRNA [Cisplatin co-treated with Lutein] results in decreased expression of GAB1 mRNA
CTD
PMID:24865317
NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236
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Gpx1
glutathione peroxidase 1
multiple interactions increases expression
ISO
Cisplatin inhibits the reaction [Lutein results in increased expression of GPX1 mRNA]; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of GPX1 mRNA]
CTD
PMID:22040935 PMID:24865317
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Gpx2
glutathione peroxidase 2
multiple interactions
ISO
[Lutein co-treated with Cisplatin] results in increased expression of GPX2 mRNA
CTD
PMID:24865317
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
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Gpx3
glutathione peroxidase 3
multiple interactions
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of GPX3 mRNA
CTD
PMID:24865317
NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
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Gsr
glutathione-disulfide reductase
increases expression multiple interactions
ISO
Lutein results in increased expression of GSR mRNA [Cisplatin co-treated with Lutein] results in decreased expression of GSR mRNA
CTD
PMID:24865317
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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Gstk1
glutathione S-transferase kappa 1
multiple interactions
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of GSTK1 mRNA
CTD
PMID:24865317
NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
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Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO
arsenic trioxide promotes the reaction [Lutein results in increased expression of HMOX1 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of HMOX1 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of HMOX1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of HMOX1 protein] Lutein results in increased expression of HMOX1 mRNA; Lutein results in increased expression of HMOX1 protein
CTD
PMID:25815309 PMID:26187899
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Idh1
isocitrate dehydrogenase (NADP(+)) 1
multiple interactions decreases expression
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of IDH1 mRNA Lutein results in decreased expression of IDH1 mRNA
CTD
PMID:24865317
NCBI chr 9:66,534,146...66,563,703
Ensembl chr 9:66,534,146...66,563,708
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Ift172
intraflagellar transport 172
multiple interactions decreases expression
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of IFT172 mRNA Lutein results in decreased expression of IFT172 mRNA
CTD
PMID:24865317
NCBI chr 6:25,081,933...25,121,271
Ensembl chr 6:25,081,980...25,120,860
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Ins1
insulin 1
multiple interactions decreases expression
EXP
[Lutein co-treated with alpha-Tocopherol] results in decreased expression of INS1 protein; [Lutein co-treated with Ascorbic Acid] results in decreased expression of INS1 protein Lutein results in decreased expression of INS1 protein
CTD
PMID:12949374
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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Kif9
kinesin family member 9
multiple interactions increases expression
ISO
Lutein promotes the reaction [Cisplatin results in decreased expression of KIF9 mRNA] Lutein results in increased expression of KIF9 mRNA
CTD
PMID:24865317
NCBI chr 8:110,459,467...110,504,492
Ensembl chr 8:110,459,383...110,505,252
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Mb
myoglobin
increases expression
ISO
Lutein results in increased expression of MB mRNA
CTD
PMID:24865317
NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
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Mgst1
microsomal glutathione S-transferase 1
multiple interactions increases expression
ISO
arsenic trioxide promotes the reaction [Lutein results in increased expression of MGST1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of MGST1 mRNA]
CTD
PMID:25815309 PMID:26187899
NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
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Miat
myocardial infarction associated transcript
multiple interactions
EXP
Lutein inhibits the reaction [Isoproterenol results in increased expression of MIAT]
CTD
PMID:34435724
NCBI chr12:44,414,620...44,429,852
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Mir200a
microRNA 200a
multiple interactions
EXP
Lutein inhibits the reaction [Isoproterenol results in decreased expression of MIR200A mRNA]
CTD
PMID:34435724
NCBI chr 5:166,648,494...166,648,582
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions increases expression
ISO EXP
arsenic trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NFE2L2 protein]; Lutein results in increased expression of and affects the localization of NFE2L2 protein Lutein results in increased expression of NFE2L2 mRNA; Lutein results in increased expression of NFE2L2 protein Lutein inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 protein]
CTD
PMID:25815309 PMID:26187899 PMID:34435724
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Ngb
neuroglobin
increases expression
ISO
Lutein results in increased expression of NGB mRNA
CTD
PMID:24865317
NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830
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Nox4
NADPH oxidase 4
multiple interactions decreases expression
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of NOX4 mRNA Lutein results in decreased expression of NOX4 mRNA
CTD
PMID:24865317
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Noxo1
NADPH oxidase organizer 1
multiple interactions
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of NOXO1 mRNA
CTD
PMID:24865317
NCBI chr10:13,723,253...13,726,008
Ensembl chr10:13,721,473...13,726,061
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions increases expression
ISO
[Cisplatin co-treated with Lutein] results in increased expression of NQO1 mRNA; arsenic trioxide promotes the reaction [Lutein results in increased expression of NQO1 mRNA]; arsenic trioxide promotes the reaction [Lutein results in increased expression of NQO1 protein]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NQO1 mRNA]; Lutein promotes the reaction [arsenic trioxide results in increased expression of NQO1 protein] Lutein results in increased expression of NQO1 mRNA; Lutein results in increased expression of NQO1 protein
CTD
PMID:24865317 PMID:25815309 PMID:26187899
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nudt15
nudix hydrolase 15
decreases expression multiple interactions
ISO
Lutein results in decreased expression of NUDT15 mRNA [Cisplatin co-treated with Lutein] results in decreased expression of NUDT15 mRNA
CTD
PMID:24865317
NCBI chr15:48,707,776...48,713,847
Ensembl chr15:48,709,700...48,747,363
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Nxn
nucleoredoxin
increases expression multiple interactions
ISO
Lutein results in increased expression of NXN mRNA Lutein inhibits the reaction [Cisplatin results in increased expression of NXN mRNA]
CTD
PMID:24865317
NCBI chr10:61,109,322...61,247,578
Ensembl chr10:61,110,020...61,248,251
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Park7
Parkinsonism associated deglycase
multiple interactions
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of PARK7 mRNA
CTD
PMID:24865317
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
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Ppp1r15b
protein phosphatase 1, regulatory subunit 15B
multiple interactions decreases expression
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of PPP1R15B mRNA Lutein results in decreased expression of PPP1R15B mRNA
CTD
PMID:24865317
NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737
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Prdx4
peroxiredoxin 4
increases expression
ISO
Lutein results in increased expression of PRDX4 mRNA
CTD
PMID:24865317
NCBI chr X:40,026,762...40,044,066
Ensembl chr X:40,026,651...40,044,066
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Prdx5
peroxiredoxin 5
decreases expression
ISO
Lutein results in decreased expression of PRDX5 mRNA
CTD
PMID:24865317
NCBI chr 1:204,099,826...204,103,589
Ensembl chr 1:204,099,826...204,114,268
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Prdx6
peroxiredoxin 6
multiple interactions decreases expression
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of PRDX6 mRNA Lutein results in decreased expression of PRDX6 mRNA
CTD
PMID:24865317
NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
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Ptgs1
prostaglandin-endoperoxide synthase 1
multiple interactions
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of PTGS1 mRNA
CTD
PMID:24865317
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
Lutein inhibits the reaction [deoxynivalenol results in increased expression of PTGS2 protein]
CTD
PMID:20347963
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
Lutein inhibits the reaction [deoxynivalenol affects the localization of RELA protein]; Lutein inhibits the reaction [deoxynivalenol results in increased expression of RELA protein]
CTD
PMID:20347963
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Scd
stearoyl-CoA desaturase
multiple interactions decreases expression
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of SCD1 mRNA Lutein results in decreased expression of SCD1 mRNA
CTD
PMID:24865317
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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Sod1
superoxide dismutase 1
multiple interactions increases expression
ISO
Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD1 mRNA] Lutein results in increased expression of SOD1 mRNA
CTD
PMID:22040935 PMID:24865317
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
multiple interactions decreases expression
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of SOD2 mRNA; Lutein inhibits the reaction [Lipopolysaccharides results in decreased expression of SOD2 mRNA] Lutein results in decreased expression of SOD2 mRNA
CTD
PMID:22040935 PMID:24865317
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sod3
superoxide dismutase 3
multiple interactions decreases expression
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of SOD3 mRNA Lutein results in decreased expression of SOD3 mRNA
CTD
PMID:24865317
NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
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Srxn1
sulfiredoxin 1
multiple interactions decreases expression
ISO
[Cisplatin co-treated with Lutein] results in decreased expression of SRXN1 mRNA Lutein results in decreased expression of SRXN1 mRNA
CTD
PMID:24865317
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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Tnnt2
troponin T2, cardiac type
multiple interactions
EXP
Lutein inhibits the reaction [Isoproterenol results in decreased expression of TNNT2 protein]
CTD
PMID:34435724
NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
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Txn1
thioredoxin 1
multiple interactions
EXP
Lutein inhibits the reaction [Isoproterenol results in decreased expression of TXN protein]
CTD
PMID:34435724
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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Txnip
thioredoxin interacting protein
multiple interactions
EXP
Lutein inhibits the reaction [Isoproterenol results in increased expression of TXNIP protein]
CTD
PMID:34435724
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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Txnrd1
thioredoxin reductase 1
decreases expression multiple interactions
ISO
Lutein results in decreased expression of TXNRD1 mRNA [Cisplatin co-treated with Lutein] results in decreased expression of TXNRD1 mRNA
CTD
PMID:24865317
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Ucp3
uncoupling protein 3
increases expression
ISO
Lutein results in increased expression of UCP3 mRNA
CTD
PMID:24865317
NCBI chr 1:154,815,777...154,828,764
Ensembl chr 1:154,815,777...154,828,762
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Vim
vimentin
increases expression
ISO
Lutein results in increased expression of VIM mRNA
CTD
PMID:24865317
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Xirp1
xin actin-binding repeat containing 1
increases expression
ISO
Lutein results in increased expression of XIRP1 mRNA
CTD
PMID:24865317
NCBI chr 8:119,744,778...119,757,547
Ensembl chr 8:119,747,419...119,757,349
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