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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:allicin
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Accession:CHEBI:28411 term browser browse the term
Definition:A botanical anti-fungal agent that has formula C6H10OS2.
Synonyms:exact_synonym: S-allyl prop-2-ene-1-sulfinothioate
 related_synonym: 2-Propene-1-sulfinothioic acid S-2-propenyl ester;   Formula=C6H10OS2;   InChI=1S/C6H10OS2/c1-3-5-8-9(7)6-4-2/h3-4H,1-2,5-6H2;   InChIKey=JDLKFOPOAOFWQN-UHFFFAOYSA-N;   SMILES=C=CCSS(=O)CC=C;   thio-2-propene-1-sulfinic acid S-allyl ester
 alt_id: CHEBI:22356;   CHEBI:2595
 xref: Beilstein:1752823;   CAS:539-86-6;   KEGG:C07600;   KNApSAcK:C00001242
 xref_mesh: MESH:C006452


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allicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein] CTD PMID:32040233 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in increased expression of BAX protein] CTD PMID:27561292 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein] CTD PMID:32040233 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein] CTD PMID:27561292 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in increased expression of CASP1 protein] CTD PMID:32040233 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:32040233 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of HMOX1 protein] CTD PMID:27561292 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO allicin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:12723939 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO
EXP		 allicin inhibits the reaction [IL1B protein affects the localization of RELA protein]; IL1B protein promotes the reaction [allicin results in increased phosphorylation of MAPK1 protein]; IL1B protein promotes the reaction [allicin results in increased phosphorylation of MAPK3 protein]
[allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; [allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; allicin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; allicin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
allicin results in increased expression of IL1B mRNA
allicin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]		 CTD PMID:25729217 PMID:32040233 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP [allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased secretion of IL4 protein] CTD PMID:25729217 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Klf9 KLF transcription factor 9 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of KLF9 protein] CTD PMID:27561292 NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO allicin results in increased phosphorylation of MAPK1 protein
IL1B protein promotes the reaction [allicin results in increased phosphorylation of MAPK1 protein]		 CTD PMID:25729217 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO IL1B protein promotes the reaction [allicin results in increased phosphorylation of MAPK3 protein] CTD PMID:25729217 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP allicin inhibits the reaction [Cyclosporine results in increased activity of MPO protein] CTD PMID:27596067 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of NFE2L2 protein] CTD PMID:27561292 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in increased expression of NLRP3 protein] CTD PMID:32040233 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of NQO1 protein] CTD PMID:27561292 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Allicin increases expression of NR1H3 mRNA in Simpson-Golabi-Behmel Syndrome cells RGD PMID:36936145 RGD:401827278 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in increased expression of RELA protein]; allicin inhibits the reaction [IL1B protein affects the localization of RELA protein] CTD PMID:25729217 PMID:27561292 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 allicin inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]; allicin inhibits the reaction [TNF protein results in increased abundance of Nitric Oxide]; allicin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
[allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; allicin inhibits the reaction [Cyclosporine results in increased expression of TNF protein]; allicin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]		 CTD PMID:12723939 PMID:25729217 PMID:27596067 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity
multiple interactions		 EXP
ISO		 allicin results in increased activity of TRPA1 protein
allicin binds to and results in increased activity of TRPA1 protein
[allicin binds to and results in increased activity of TRPA1 protein] which results in increased transport of Calcium; allicin binds to and results in increased activity of TRPA1 protein		 CTD PMID:17684094 PMID:17825279 PMID:20086034 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects response to substance
increases response to substance		 ISO TRPV1 protein affects the susceptibility to allicin
TRPV1 protein mutant form results in increased susceptibility to allicin		 CTD PMID:17110039 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19874
    role 19844
      biological role 19842
        antimicrobial agent 18240
          antibacterial agent 16364
            allicin 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19874
    subatomic particle 19872
      composite particle 19872
        hadron 19872
          baryon 19872
            nucleon 19872
              atomic nucleus 19872
                atom 19872
                  main group element atom 19811
                    p-block element atom 19811
                      carbon group element atom 19751
                        carbon atom 19748
                          organic molecular entity 19748
                            heteroorganic entity 19505
                              organochalcogen compound 19268
                                organosulfur compound 17449
                                  sulfoxide 6529
                                    allicin 22
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