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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:allicin
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Accession:CHEBI:28411 term browser browse the term
Definition:A botanical anti-fungal agent that has formula C6H10OS2.
Synonyms:exact_synonym: S-allyl prop-2-ene-1-sulfinothioate
 related_synonym: 2-Propene-1-sulfinothioic acid S-2-propenyl ester;   Formula=C6H10OS2;   InChI=1S/C6H10OS2/c1-3-5-8-9(7)6-4-2/h3-4H,1-2,5-6H2;   InChIKey=JDLKFOPOAOFWQN-UHFFFAOYSA-N;   SMILES=C=CCSS(=O)CC=C;   thio-2-propene-1-sulfinic acid S-allyl ester
 alt_id: CHEBI:22356;   CHEBI:2595
 xref: Beilstein:1752823;   CAS:539-86-6;   KEGG:C07600;   KNApSAcK:C00001242
 xref_mesh: MESH:C006452


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allicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in decreased expression of ALB protein] CTD PMID:32040233 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in increased expression of BAX protein] CTD PMID:27561292 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein] CTD PMID:32040233 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein] CTD PMID:27561292 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in increased expression of CASP1 protein] CTD PMID:32040233 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:32040233 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of HMOX1 protein] CTD PMID:27561292 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO allicin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:12723939 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression 		ISO
EXP 		allicin inhibits the reaction [IL1B protein affects the localization of RELA protein]; IL1B protein promotes the reaction [allicin results in increased phosphorylation of MAPK1 protein]; IL1B protein promotes the reaction [allicin results in increased phosphorylation of MAPK3 protein]
[allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; [allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]; allicin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B mRNA]; allicin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
allicin results in increased expression of IL1B mRNA
allicin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein] 		CTD PMID:25729217 PMID:32040233 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 multiple interactions EXP [allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased secretion of IL4 protein] CTD PMID:25729217 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Klf9 KLF transcription factor 9 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of KLF9 protein] CTD PMID:27561292 NCBI chr 1:230,126,646...230,151,641
Ensembl chr 1:230,126,646...230,151,641 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions 		ISO allicin results in increased phosphorylation of MAPK1 protein
IL1B protein promotes the reaction [allicin results in increased phosphorylation of MAPK1 protein] 		CTD PMID:25729217 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation 		ISO IL1B protein promotes the reaction [allicin results in increased phosphorylation of MAPK3 protein] CTD PMID:25729217 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP allicin inhibits the reaction [Cyclosporine results in increased activity of MPO protein] CTD PMID:27596067 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of NFE2L2 protein] CTD PMID:27561292 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO allicin inhibits the reaction [Acetaminophen results in increased expression of NLRP3 protein] CTD PMID:32040233 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in decreased expression of NQO1 protein] CTD PMID:27561292 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO Allicin increases expression of NR1H3 mRNA in Simpson-Golabi-Behmel Syndrome cells RGD PMID:36936145 RGD:401827278 NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:97,614,616...97,624,532 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO allicin inhibits the reaction [arsenic trioxide results in increased expression of RELA protein]; allicin inhibits the reaction [IL1B protein affects the localization of RELA protein] CTD PMID:25729217 PMID:27561292 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP 		allicin inhibits the reaction [TNF protein results in increased abundance of Hydrogen Peroxide]; allicin inhibits the reaction [TNF protein results in increased abundance of Nitric Oxide]; allicin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
[allicin co-treated with Mesalamine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; [allicin co-treated with Sulfasalazine] inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]; allicin inhibits the reaction [Cyclosporine results in increased expression of TNF protein]; allicin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein] 		CTD PMID:12723939 PMID:25729217 PMID:27596067 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity
multiple interactions 		EXP
ISO 		allicin results in increased activity of TRPA1 protein
allicin binds to and results in increased activity of TRPA1 protein
[allicin binds to and results in increased activity of TRPA1 protein] which results in increased transport of Calcium; allicin binds to and results in increased activity of TRPA1 protein 		CTD PMID:17684094 PMID:17825279 PMID:20086034 NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:9,163,060...9,217,325 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 affects response to substance
increases response to substance 		ISO TRPV1 protein affects the susceptibility to allicin
TRPV1 protein mutant form results in increased susceptibility to allicin 		CTD PMID:17110039 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        antimicrobial agent 18578
          antibacterial agent 16665
            allicin 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organosulfur compound 17763
                                  sulfoxide 6555
                                    allicin 22
paths to the root